PRESENTATION ON

BALO-10

Prepared by:Biplob Kumar Sarker,

Product Executive,Product Management Department

DISEASE PART

Skeletal muscle: Skeletal muscle is a type of striated muscle,

attached to the skeleton. Skeletal muscles are used to facilitate movement,

by applying force to bones and joints; via contraction.

They generally contract voluntarily (via nerve stimulation), although they can contract involuntarily.

DISEASE OF SKELETAL MUSCLE

Spasticity: It is referred to as an unusual “tightness”

stiffness or “pull” of muscles. The word spasm comes from the Greek word

spasmo meaning “drawing pulling”.

SPASTIC DISORDERS

CONT…

Muscle spasm: A spasm is a sudden, involuntary contraction of a

muscle, a group of muscles, or a hollow organ such as a heart, or a similarly sudden contraction of an office.

CONT… Muscular rigidity: Muscle rigidity is a state of firm, tense muscles

with marked resistance to passive movement.

CONT…

Low back pain: Low back pain refers to pain that you feel in your

lower back. You may also have back stiffness, decreased movement of the lower back, and difficulty standing straight.

Intractable hiccups: A hiccups is an involuntary contraction of the

diaphragm that may repeat several times per minute.

CONT…

CONT… Trigeminal neuralgia: Also known as prosopalgin, or Fothergill’s

disease is a neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve.

CONT…

Dysfunctional voiding: Dysfunctional voiding is characterized by an

intermittent and/or fluctuating flow rate due to involuntary intermittent contractions of the periurethral striated or levator muscles during voiding in neurologically normal people.

CONT…

Tension type headache: Headache from tension.

CONT…

Migraine: A migraine is usually a severe headache felt as a

throbbing pain at the front or side of the head.

CONT…

Cluster headache: It is a neurological disorder characterized by

recurrent, severe headaches on the side of the head, typically around the eye.

TREATMENT OPTION

Apply a skeletal muscle relaxant for thee time in a day.

Medicon introduces

Balo-10Baclofen 10 mg

PRODUCT PROFILE

Brand Name : Balo-10

Generic Name : Baclofen

Therapeutic Group :Skeletal Muscle Relaxant

Official specification : BP

Dosage Form : Tablet

Strength : 10 mg

Pack Size : 3x10’s

Selling Price/box : Tk. 198

MRP/ box : Tk. 240

INDICATION

Balo-10 is indicated for the treatment of:

SpasticityMuscle spasmMuscular rigidityLow back painIntractable hiccups

CON…

Trigeminal neuralgiaDysfunctional voidingTension type headacheMigraineCluster headache

MECHANISM OF ACTION

Baclofen, inhibits monosynaptic and polysynaptic reflexes at the spinal level by hyperpolarization of afferent terminals.

Baclofen, enhances the activities of the inhibitory neurotransmitter GABA and Glycin

Baclofen, decreases the release of the excitatory neurotransmitter Aspartate and Glutamate

CON…

DOSAGE AND ADMINISTRATION

Start therapy from the lowest possible dose and gradually increase to achieve optimum result.

Following titration schedule is suggested-  05 mg t.i.d. for 3 days 10 mg t.i.d. for 3 days 15 mg t.i.d. for 3 days 20  mg t.i.d. for 3 days 

The total dose should not exceed the maximum of 80 mg daily ( 20 mg q.i.d.)

TARGET DOCTORS

-Medicine Specialist

-Neurologist

-Orthopedic Specialist

-Cardiologist

- Gynecologist

-Potential GPs

-RMP/PC

-Skin and VD Specialist

MAJOR COMPETITORS Brand Name Company

Beklo OpsoninLioresal NovertisSkelofen ACMEFlexibac BeaconRamback MonicoBaclofen ApexSpafen RAKStarbac LeonBacaid 10 LabaidLiosal DeltaLirosal NoveltaMyobac Navana

SHORT-TERM OBJECTIVE

Prescription: Per MPO Prescription target

Five(2) Prescriptions/Day/Target doctors

Sales:Per MPO sales Target Balo-10 Tablet: 30 Boxes

LONG TERM OBJECTIVE

To make Balo-10 a brand leader in Skeletal Muscle Relaxants Preparation by creating prescription from potential qualified doctors.

SPECIAL BENEFITS OF BALO-10

Highly Effective against Spasticity. Ensure confidence in treating acute low-back

syndrome

Safe up to 6 years (long term treatment for spastic disorders)

Higher bio-availability (70-80%) ensures higher clinical effect

CONT…

Very low stress on liver due to low metabolism ( 15 %) on liver

Devoid of dry mouth and sedation Free from Tolperisone like bad smell Co-administration with Ciprofloxacin and oral

contraceptives is feasible.