Bacteria Corynebacterium Listeria BordetellaLab ID Gram positive rods,

pleomorphic (V and Y shapes)

Grows best at cold temperaturesGram positive rods

Aerobic gram negative rods

Virulence Factor A-B toxin: B subunit binds, A subunit inhibits eF2 thus stopping protein synthesis and initiates DNA fragmentation and cytolysisTox gene: Fe + dtxR (repressor) bind to promoter to regulate toxin production (no toxin in presence of Fe)

Able to grow intracellularly in the cytoplasm via listeriolysin OInvade adjacent cells via polymerization of host actin by actA

Bacterial attachment to cilia of respiratory epithelial cells enhances toxin effectPertussis toxinFilamentous hemagglutininPertactinFimbriaTracheal cytotoxin

Infection characteristics

Diptheria – upper respiratory infects plus skin.Makes an adherent membrane that is hard to remove and causes swallowing/breathing difficulty

Flu-like illness, gastroenteritis, bacteremia, CNS infection (meningitis and brain abscess)Listeriosis: mild impairment of cell immunity usually 3rd

trimester or pregnancyNeonatal listeriosis: can occur in utero or after birth (fever is a sign)

Pertussis: cause acute respiratory tract infectionSeen more in younger system because immunity is not yet complete3 Stages1. catarrhal stage (runny nose)2. paroxysmal stage (harsh cough)3. Convalescence (coughing less)

Vaccine Toxoid (inactivated toxin) DTap or Tdap when older

DTaP