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Revolutionizing Autograft Harvesting

with the Avitus® Bone Harvester

Avitus® Orthopaedics, Inc.

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Previously Product Development – Jhpiego

Previous engineering experience with

Advanced Power Systems and

Westinghouse

M.S.E. Biomedical Engineering – Johns

Hopkins Univ.

Meet the Founders

Maxim Budyansky

Co-Founder & CTO

Neil Shah

Co-Founder & CEO

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Previous Deputy Director, Johns Hopkins

Coulter Translational Program

Previous engineering experience with J&J

and NASA

M.S.E. Biomedical Engineering – Johns

Hopkins Univ.

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Milestones to Date

✓ Commercialized Avitus® Bone Harvester

✓ Patented in USA & International

✓ FDA cleared

✓ 1,300+ surgeries completed in the US

✓ $1M+ annual revenue

The ASK - $10M Series B for:

✓ Product portfolio expansion

✓ Team expansion

✓ Investment in profitable S&M channels

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The Problem

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1. Harvested

here

2. Delivered

here

Bone graft is used by orthopaedic surgeons to heal

broken/diseased bones. Harvesting bone graft is the problem…

▪ Patient Pain// 3-12 months post-operative

▪ Invasive Surgery// 3-9cm incision

▪ Time Consuming// 25-45 min

HARVESTING PAIN POINTS

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Open Harvesting vs. Avitus®

Avitus® Bone Harvester

Open Procedure

Min. Invasive: 1-2cm

Invasive: 3-9cm

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Avitus® Bone Harvester

1-2 cm entry 5 min harvest time 5-45CC graft + marrow

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Hear From Our Users

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I have used the Avitus in over 40 cases - it has

become my standard of practice for bone

grafting procedures.

Alan Davis, MD

Orthopaedic Surgeon

Foot and Ankle Surgery

Cleveland Clinic

The cost was 1/3rd of the price of the orthobiologic

protein typically used and obviated the need for any

additional structural grafts. The rate of fusion was fast

and robust. It fused like gangbusters!

Christopher Kreulen, MD, MS

Orthopaedic Surgeon

Sports / Foot & Ankle Surgery

University of California

Davis Medical Center

I would recommend the Avitus® Bone

Harvester when large amounts of cancellous

bone are needed for trauma reconstructions

and nonunion procedures.

Steven Regal, MD

Orthopaedic Surgeon

Hand and Upper Extremity

Pittsburgh, PA

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Platform Applications

Clinical Applications▪ Foot & Ankle fusions

▪ Trauma non-unions & fractures

▪ Orthopaedic reconstructions

▪ Wrist fusions

▪ Upper extremities

▪ Limb salvage

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CALCANEUS

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Avitus® vs Other Harvesters

Avitus® Harvest

✓ Significantly more volume

✓ Gets graft + marrow

✓ Effective for replacing

expensive bone graft

substitutes

Source: https://www.paradigmbiodevices.com/

30cc graft

15cc marrow

7cc graft

Trephine Harvest

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Avitus® vs Bone Graft Substitutes

# Based on average selling price and average volume of cancellous bone graft harvested by the Avitus® Bone Harvester.

× Based on average cost of 10cc pack of bone graft substitute + average cost of standard jamshidi needle for BMA draw.

WE HAVE SAVED HOSPITALS $1,500-$8,000PER SURGERY BY REPLACING SUBSTITUTES!

✓ Higher fusion rates

✓ Decreased fusion site

complications

✓ Lower costs• $1-5K / 10cc for Substitutes

• $1K / 30cc for Avitus®

Benefits of

Autograft vs Substitutes

$400+

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Market Traction // Select Customers

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800+

Cases

Last 12 Months

$1M+

Sales

110%

YOY

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Market Expansion Strategy

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Line Extensions &

Ancillary Products

Other

Foot & Ankle

Conditions

Other Clinical

Markets

(e.g., Spine)

International

Markets

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Initial Target Market

US Foot & Ankle Bone Grafting▪ Gain Repeat Users

▪ Develop Anchor Customers

▪ Build Market Awareness

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2019 2020 2021 2022 2023 2024 2025

MIL

LIO

NS

Revenue Projections

The ASK

We are raising $10 million in Series B

financing to achieve $50+ million in

revenues by 2025

By 2023, Cashflow positive and

$26M revenues

Funds needed prior to cash flow

positive = $6.3M

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Summary

Demonstrated high-margin business model

Strong, profitable growth potential

Highly capital efficient management

Patented technology portfolio with

strong value proposition & market positioning14

Confidential Thank You!