HAMILTON Life Science Robotics

Automation Solutions to Enable PhyNexus Applications

Bronson Duck August 27th, 2014

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About Hamilton • Global Company • Provides world-class analytical components, medical instrumentation, sensors, laboratory robotics and automated liquid handling equipment. • High quality products • Superior service and customer satisfaction

Clark Hamilton, Founder of Hamilton Company, started the company in his garage in 1950 and today, Hamilton is a proud employer of over 1200

employees worldwide.

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Tools that Enable PhyNexus Applications

Modules

Configurations

Accessories

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Hamilton Robotics – Platform Products

MICROLAB VANTAGE

MICROLAB STAR

MICROLAB NIMBUS

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Microlab STAR – The Success Story

Microlab STAR

1,000s of Installations Around the World

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Key Innovations - CO-RE Technology

CO-RE = Compression-induced O-Ring Expansion

• Disposable tips and steel washable needles on the same head, during the same run

• Highest positional accuracy along all axes

• Stress-free Tip Pick-Up • Contamination-free tip drop-off • Universal Tool

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Pipetting Channels

• Monitored Air Displacement Pipetting principle (MAD)

No system liquid, no tubing, no pumps

• Channel Capacity 1000µl • Pipetting Heads with Independent

Volume from 0.5 – 1000µl Pipetting height Asymmetric, variable span in Y direction

• Totally accessible deck Each channel accesses each well on all

pipetting locations

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96 Pipetting Channels with One volume: 1µl - 1000µl

CO-RE Technology Offers

1 Tip row pick-up 1 Tip column pick-up

High Throughput

CO-RE 96-probe Head

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Hamilton STAR Solution

STAR ML 8/96 Key Hardware

1mL CORE 96 Head Tip Column Drying Station Chilled Positions for Sample Stability

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CORE 96 Head

STAR ML 8/96 Key Hardware

1mL CORE 96 Head Tip Column Drying Station Clear 1mL Tips supplied to PhyNexus

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PhyNexus Drying Station

STAR ML 8/96 Key Hardware

1mL CORE 96 Head Tip Column Drying Station Clear 1mL Tips supplied to PhyNexus

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Chilled Carrier

Chilled Positions for Sample Stability

Temperature Control down to 4°C

5 – 45 Temperature Controlled Positions

Allows for additional throughput and longer walk-away times

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Microlab STARline – 3 Sizes

STARlet (25 SBS)

STAR (45 SBS)

STARplus (55 SBS)

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Ability to Automate Additional Applications

Vacuum based purifications Magnetic bead based purifications PCR/sequencing set-ups Cloning Protein crystallization In-gel digestion MALDI target spotting Cell culture Cell based assays Antibody production RNAi, reporter gene screening Solid phase and liquid/liquid extraction PAMPA and other ADME(T) Combichem

Check: www.hamiltonrobotics.com

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iSWAP Robotic Plate Handler

• Access Internal and External Positions

• Process Control Through Force Sensor

• Mimics Human Arm • Default Positions for

Labware • Fully Compatible with

1 - 16 Single Channels • Landscape and Portrait

Plate Gripping

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CO-RE Grip Plate Handler

• Small Budget Plate Handler • Tool Picked-up by Two

Channels • Default Positions for

Labware • Reaches All Deck Space • Landscape and Portrait

Plate Gripping • Facilitates Stacking

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STAR DeCapper

• Consists of Twister Channels and DeCapper Modules • Supports manipulation of a variety of tube diameters & heights • Integrated barcode reader on each Twister Channel • 1500 rpm mixing speed

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STAR Configuration - Loading

Autoload/Barcode Reading

Manual Load

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Key Benefits to Automating PhyNexus Applications on a Hamilton Robotics Platform

• CORE 96 Head • 1mL Capacity allows for a wide range of PhyNexus applications • Increased throughput

• Air Displacement Pipetting Technology • Allows for more mixing cycles without disrupting or resetting air

gaps in fluid filled lines

• Functionality & Flexibility • Ability not only to automate protein and plasmid DNA

purifications, but additional liquid handling tasks • Many configuration and accessory options allow for automation

of practically any liquid handling task

• Worldwide Service & Support Organization

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Hamilton Life Science Robotics