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Copyright Dr Marc Halpern and the
California College of Ayurveda
Definition and Introduction The role of the immune system
To keep the body healthy by destroying that which it perceives to be non-self
Autoimmune Disease
The body mistakes normal tissue for non-self and begins to attack the tissue in an attempt to destroy it
Epidemiology
Prevalence 3 -9 of US population afflicted with tissue specific or systemic autoimmune disease (111)
Number of diseases 80+
Male Femle Woman have a much higher incidecenwith some conditions occuring 80 ndash 90 in woman 85 of sjogrens syndrome thyroiditis lupus and
systemic sclerosis
Common Autoimmune Diseases Rheumatoid Arthritis
Systemic Lupus
Hyper and Hypo Thyroid
Multiple Sclerosis
Pernicious and hemolytic anemias
Diabetes Mellitus
Vitiligo
Psoriasis
Chronersquos disease
Ulcerative Colitis
Celiac Disease
Possible Autoimmune Components
Fibromyalgia
Lymersquos Disease
What is the causeA Western Perspective
Micro-organisms
Hidden
Cross Reactivity
Strept throat and Rheumatic heart disease
Alterations in Normal Tissue
Radiation chemical toxicity viruses
B-lymphocyte Malfunction due to alteration from radiation etc
Genetic tendencies activated by drug use or micro-organisms or stress
Sequestered antigens Lymphoid cells that are not exposed to certain self-antigens during their development and so never develop tolerance (4)
Etiology and Pathology Thymus Dysfunction Self-reacting lymphoid cells
should be negatively selected if they are sensitive to self antigens They should undergo apoptosis (programmed cell death) - Called Failure of Clonal Deletion (4)
Fewer Suppressor T-cell Failure to regulate immune responses Some patients have fewer of these cells (4)
Abnormal function of T helper cells Alterations in cytokine production
Xenoestrogens may result in suppression of cell mediated immunity and stimulation of humeral immunity
What Happens The reaction triggers abnormal reactions within the
tissues resulting in (1)
Inflammation and or tissue destruction
Excessive growth
Altered function
Factors Increasing Your Risk Cigarette smoking RA+
SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5
years period (Relationship job financial) (RA)
Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral
infections (SLE)
Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure
(General) Drugs and contaminants
of Canola oil Tryptophan procainamide interferon
Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)
Factors Decreasing Risk Breast Fed
Protects against RA and SLE
Past Urinary Tract Infections
Protects against RA
Past Rubella Infection (German Measles)
Protects against RA
Most Common Tissues Affected Red Blood Cells
Pernicious Anemia Hemolytic anemia
Blood Vessels
Vasculitis
Endocrine Glands (Thyroid Adrenal Pancreas)
Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus
Most Common Tissues Affected Muscle Nerve
Multiple sclerosis Myesthenia gravis Joints
Rheumatoid Arthritis SLE Skin and muscle
Dermatomyositis Psoriasis Vitiligo Organ Disease
Digestive system Chronersquos disease Celiac disease Ulcerative
colitis
Generalized SymptomsCommon symptoms
Tissue specific Inflammation and or destruction
Generalize Fatigue dizziness weakness
Possible low Grade Fever
Specific Symptoms
Vary with the individual disease
Most Important General Blood Tests
ESR and CRP
These measure inflammation in the body The numbers rise as tissue destruction becomes more active
Can be used to monitor the condition and assess the success of treatment
Common Western Drug TreatmentImmune Suppressive Drugs
Anti-inflammatory Corticosteroids such as prednisone
Non-steroidal anti-inflammatory drugs
Immune suppressive drugs cyclophosphamide azathioprine cyclosporine
General CourseAs a group they tend to be chronic
Prone to remission and flare -ups
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Definition and Introduction The role of the immune system
To keep the body healthy by destroying that which it perceives to be non-self
Autoimmune Disease
The body mistakes normal tissue for non-self and begins to attack the tissue in an attempt to destroy it
Epidemiology
Prevalence 3 -9 of US population afflicted with tissue specific or systemic autoimmune disease (111)
Number of diseases 80+
Male Femle Woman have a much higher incidecenwith some conditions occuring 80 ndash 90 in woman 85 of sjogrens syndrome thyroiditis lupus and
systemic sclerosis
Common Autoimmune Diseases Rheumatoid Arthritis
Systemic Lupus
Hyper and Hypo Thyroid
Multiple Sclerosis
Pernicious and hemolytic anemias
Diabetes Mellitus
Vitiligo
Psoriasis
Chronersquos disease
Ulcerative Colitis
Celiac Disease
Possible Autoimmune Components
Fibromyalgia
Lymersquos Disease
What is the causeA Western Perspective
Micro-organisms
Hidden
Cross Reactivity
Strept throat and Rheumatic heart disease
Alterations in Normal Tissue
Radiation chemical toxicity viruses
B-lymphocyte Malfunction due to alteration from radiation etc
Genetic tendencies activated by drug use or micro-organisms or stress
Sequestered antigens Lymphoid cells that are not exposed to certain self-antigens during their development and so never develop tolerance (4)
Etiology and Pathology Thymus Dysfunction Self-reacting lymphoid cells
should be negatively selected if they are sensitive to self antigens They should undergo apoptosis (programmed cell death) - Called Failure of Clonal Deletion (4)
Fewer Suppressor T-cell Failure to regulate immune responses Some patients have fewer of these cells (4)
Abnormal function of T helper cells Alterations in cytokine production
Xenoestrogens may result in suppression of cell mediated immunity and stimulation of humeral immunity
What Happens The reaction triggers abnormal reactions within the
tissues resulting in (1)
Inflammation and or tissue destruction
Excessive growth
Altered function
Factors Increasing Your Risk Cigarette smoking RA+
SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5
years period (Relationship job financial) (RA)
Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral
infections (SLE)
Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure
(General) Drugs and contaminants
of Canola oil Tryptophan procainamide interferon
Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)
Factors Decreasing Risk Breast Fed
Protects against RA and SLE
Past Urinary Tract Infections
Protects against RA
Past Rubella Infection (German Measles)
Protects against RA
Most Common Tissues Affected Red Blood Cells
Pernicious Anemia Hemolytic anemia
Blood Vessels
Vasculitis
Endocrine Glands (Thyroid Adrenal Pancreas)
Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus
Most Common Tissues Affected Muscle Nerve
Multiple sclerosis Myesthenia gravis Joints
Rheumatoid Arthritis SLE Skin and muscle
Dermatomyositis Psoriasis Vitiligo Organ Disease
Digestive system Chronersquos disease Celiac disease Ulcerative
colitis
Generalized SymptomsCommon symptoms
Tissue specific Inflammation and or destruction
Generalize Fatigue dizziness weakness
Possible low Grade Fever
Specific Symptoms
Vary with the individual disease
Most Important General Blood Tests
ESR and CRP
These measure inflammation in the body The numbers rise as tissue destruction becomes more active
Can be used to monitor the condition and assess the success of treatment
Common Western Drug TreatmentImmune Suppressive Drugs
Anti-inflammatory Corticosteroids such as prednisone
Non-steroidal anti-inflammatory drugs
Immune suppressive drugs cyclophosphamide azathioprine cyclosporine
General CourseAs a group they tend to be chronic
Prone to remission and flare -ups
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Epidemiology
Prevalence 3 -9 of US population afflicted with tissue specific or systemic autoimmune disease (111)
Number of diseases 80+
Male Femle Woman have a much higher incidecenwith some conditions occuring 80 ndash 90 in woman 85 of sjogrens syndrome thyroiditis lupus and
systemic sclerosis
Common Autoimmune Diseases Rheumatoid Arthritis
Systemic Lupus
Hyper and Hypo Thyroid
Multiple Sclerosis
Pernicious and hemolytic anemias
Diabetes Mellitus
Vitiligo
Psoriasis
Chronersquos disease
Ulcerative Colitis
Celiac Disease
Possible Autoimmune Components
Fibromyalgia
Lymersquos Disease
What is the causeA Western Perspective
Micro-organisms
Hidden
Cross Reactivity
Strept throat and Rheumatic heart disease
Alterations in Normal Tissue
Radiation chemical toxicity viruses
B-lymphocyte Malfunction due to alteration from radiation etc
Genetic tendencies activated by drug use or micro-organisms or stress
Sequestered antigens Lymphoid cells that are not exposed to certain self-antigens during their development and so never develop tolerance (4)
Etiology and Pathology Thymus Dysfunction Self-reacting lymphoid cells
should be negatively selected if they are sensitive to self antigens They should undergo apoptosis (programmed cell death) - Called Failure of Clonal Deletion (4)
Fewer Suppressor T-cell Failure to regulate immune responses Some patients have fewer of these cells (4)
Abnormal function of T helper cells Alterations in cytokine production
Xenoestrogens may result in suppression of cell mediated immunity and stimulation of humeral immunity
What Happens The reaction triggers abnormal reactions within the
tissues resulting in (1)
Inflammation and or tissue destruction
Excessive growth
Altered function
Factors Increasing Your Risk Cigarette smoking RA+
SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5
years period (Relationship job financial) (RA)
Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral
infections (SLE)
Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure
(General) Drugs and contaminants
of Canola oil Tryptophan procainamide interferon
Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)
Factors Decreasing Risk Breast Fed
Protects against RA and SLE
Past Urinary Tract Infections
Protects against RA
Past Rubella Infection (German Measles)
Protects against RA
Most Common Tissues Affected Red Blood Cells
Pernicious Anemia Hemolytic anemia
Blood Vessels
Vasculitis
Endocrine Glands (Thyroid Adrenal Pancreas)
Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus
Most Common Tissues Affected Muscle Nerve
Multiple sclerosis Myesthenia gravis Joints
Rheumatoid Arthritis SLE Skin and muscle
Dermatomyositis Psoriasis Vitiligo Organ Disease
Digestive system Chronersquos disease Celiac disease Ulcerative
colitis
Generalized SymptomsCommon symptoms
Tissue specific Inflammation and or destruction
Generalize Fatigue dizziness weakness
Possible low Grade Fever
Specific Symptoms
Vary with the individual disease
Most Important General Blood Tests
ESR and CRP
These measure inflammation in the body The numbers rise as tissue destruction becomes more active
Can be used to monitor the condition and assess the success of treatment
Common Western Drug TreatmentImmune Suppressive Drugs
Anti-inflammatory Corticosteroids such as prednisone
Non-steroidal anti-inflammatory drugs
Immune suppressive drugs cyclophosphamide azathioprine cyclosporine
General CourseAs a group they tend to be chronic
Prone to remission and flare -ups
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Common Autoimmune Diseases Rheumatoid Arthritis
Systemic Lupus
Hyper and Hypo Thyroid
Multiple Sclerosis
Pernicious and hemolytic anemias
Diabetes Mellitus
Vitiligo
Psoriasis
Chronersquos disease
Ulcerative Colitis
Celiac Disease
Possible Autoimmune Components
Fibromyalgia
Lymersquos Disease
What is the causeA Western Perspective
Micro-organisms
Hidden
Cross Reactivity
Strept throat and Rheumatic heart disease
Alterations in Normal Tissue
Radiation chemical toxicity viruses
B-lymphocyte Malfunction due to alteration from radiation etc
Genetic tendencies activated by drug use or micro-organisms or stress
Sequestered antigens Lymphoid cells that are not exposed to certain self-antigens during their development and so never develop tolerance (4)
Etiology and Pathology Thymus Dysfunction Self-reacting lymphoid cells
should be negatively selected if they are sensitive to self antigens They should undergo apoptosis (programmed cell death) - Called Failure of Clonal Deletion (4)
Fewer Suppressor T-cell Failure to regulate immune responses Some patients have fewer of these cells (4)
Abnormal function of T helper cells Alterations in cytokine production
Xenoestrogens may result in suppression of cell mediated immunity and stimulation of humeral immunity
What Happens The reaction triggers abnormal reactions within the
tissues resulting in (1)
Inflammation and or tissue destruction
Excessive growth
Altered function
Factors Increasing Your Risk Cigarette smoking RA+
SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5
years period (Relationship job financial) (RA)
Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral
infections (SLE)
Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure
(General) Drugs and contaminants
of Canola oil Tryptophan procainamide interferon
Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)
Factors Decreasing Risk Breast Fed
Protects against RA and SLE
Past Urinary Tract Infections
Protects against RA
Past Rubella Infection (German Measles)
Protects against RA
Most Common Tissues Affected Red Blood Cells
Pernicious Anemia Hemolytic anemia
Blood Vessels
Vasculitis
Endocrine Glands (Thyroid Adrenal Pancreas)
Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus
Most Common Tissues Affected Muscle Nerve
Multiple sclerosis Myesthenia gravis Joints
Rheumatoid Arthritis SLE Skin and muscle
Dermatomyositis Psoriasis Vitiligo Organ Disease
Digestive system Chronersquos disease Celiac disease Ulcerative
colitis
Generalized SymptomsCommon symptoms
Tissue specific Inflammation and or destruction
Generalize Fatigue dizziness weakness
Possible low Grade Fever
Specific Symptoms
Vary with the individual disease
Most Important General Blood Tests
ESR and CRP
These measure inflammation in the body The numbers rise as tissue destruction becomes more active
Can be used to monitor the condition and assess the success of treatment
Common Western Drug TreatmentImmune Suppressive Drugs
Anti-inflammatory Corticosteroids such as prednisone
Non-steroidal anti-inflammatory drugs
Immune suppressive drugs cyclophosphamide azathioprine cyclosporine
General CourseAs a group they tend to be chronic
Prone to remission and flare -ups
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
What is the causeA Western Perspective
Micro-organisms
Hidden
Cross Reactivity
Strept throat and Rheumatic heart disease
Alterations in Normal Tissue
Radiation chemical toxicity viruses
B-lymphocyte Malfunction due to alteration from radiation etc
Genetic tendencies activated by drug use or micro-organisms or stress
Sequestered antigens Lymphoid cells that are not exposed to certain self-antigens during their development and so never develop tolerance (4)
Etiology and Pathology Thymus Dysfunction Self-reacting lymphoid cells
should be negatively selected if they are sensitive to self antigens They should undergo apoptosis (programmed cell death) - Called Failure of Clonal Deletion (4)
Fewer Suppressor T-cell Failure to regulate immune responses Some patients have fewer of these cells (4)
Abnormal function of T helper cells Alterations in cytokine production
Xenoestrogens may result in suppression of cell mediated immunity and stimulation of humeral immunity
What Happens The reaction triggers abnormal reactions within the
tissues resulting in (1)
Inflammation and or tissue destruction
Excessive growth
Altered function
Factors Increasing Your Risk Cigarette smoking RA+
SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5
years period (Relationship job financial) (RA)
Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral
infections (SLE)
Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure
(General) Drugs and contaminants
of Canola oil Tryptophan procainamide interferon
Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)
Factors Decreasing Risk Breast Fed
Protects against RA and SLE
Past Urinary Tract Infections
Protects against RA
Past Rubella Infection (German Measles)
Protects against RA
Most Common Tissues Affected Red Blood Cells
Pernicious Anemia Hemolytic anemia
Blood Vessels
Vasculitis
Endocrine Glands (Thyroid Adrenal Pancreas)
Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus
Most Common Tissues Affected Muscle Nerve
Multiple sclerosis Myesthenia gravis Joints
Rheumatoid Arthritis SLE Skin and muscle
Dermatomyositis Psoriasis Vitiligo Organ Disease
Digestive system Chronersquos disease Celiac disease Ulcerative
colitis
Generalized SymptomsCommon symptoms
Tissue specific Inflammation and or destruction
Generalize Fatigue dizziness weakness
Possible low Grade Fever
Specific Symptoms
Vary with the individual disease
Most Important General Blood Tests
ESR and CRP
These measure inflammation in the body The numbers rise as tissue destruction becomes more active
Can be used to monitor the condition and assess the success of treatment
Common Western Drug TreatmentImmune Suppressive Drugs
Anti-inflammatory Corticosteroids such as prednisone
Non-steroidal anti-inflammatory drugs
Immune suppressive drugs cyclophosphamide azathioprine cyclosporine
General CourseAs a group they tend to be chronic
Prone to remission and flare -ups
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Etiology and Pathology Thymus Dysfunction Self-reacting lymphoid cells
should be negatively selected if they are sensitive to self antigens They should undergo apoptosis (programmed cell death) - Called Failure of Clonal Deletion (4)
Fewer Suppressor T-cell Failure to regulate immune responses Some patients have fewer of these cells (4)
Abnormal function of T helper cells Alterations in cytokine production
Xenoestrogens may result in suppression of cell mediated immunity and stimulation of humeral immunity
What Happens The reaction triggers abnormal reactions within the
tissues resulting in (1)
Inflammation and or tissue destruction
Excessive growth
Altered function
Factors Increasing Your Risk Cigarette smoking RA+
SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5
years period (Relationship job financial) (RA)
Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral
infections (SLE)
Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure
(General) Drugs and contaminants
of Canola oil Tryptophan procainamide interferon
Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)
Factors Decreasing Risk Breast Fed
Protects against RA and SLE
Past Urinary Tract Infections
Protects against RA
Past Rubella Infection (German Measles)
Protects against RA
Most Common Tissues Affected Red Blood Cells
Pernicious Anemia Hemolytic anemia
Blood Vessels
Vasculitis
Endocrine Glands (Thyroid Adrenal Pancreas)
Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus
Most Common Tissues Affected Muscle Nerve
Multiple sclerosis Myesthenia gravis Joints
Rheumatoid Arthritis SLE Skin and muscle
Dermatomyositis Psoriasis Vitiligo Organ Disease
Digestive system Chronersquos disease Celiac disease Ulcerative
colitis
Generalized SymptomsCommon symptoms
Tissue specific Inflammation and or destruction
Generalize Fatigue dizziness weakness
Possible low Grade Fever
Specific Symptoms
Vary with the individual disease
Most Important General Blood Tests
ESR and CRP
These measure inflammation in the body The numbers rise as tissue destruction becomes more active
Can be used to monitor the condition and assess the success of treatment
Common Western Drug TreatmentImmune Suppressive Drugs
Anti-inflammatory Corticosteroids such as prednisone
Non-steroidal anti-inflammatory drugs
Immune suppressive drugs cyclophosphamide azathioprine cyclosporine
General CourseAs a group they tend to be chronic
Prone to remission and flare -ups
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
What Happens The reaction triggers abnormal reactions within the
tissues resulting in (1)
Inflammation and or tissue destruction
Excessive growth
Altered function
Factors Increasing Your Risk Cigarette smoking RA+
SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5
years period (Relationship job financial) (RA)
Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral
infections (SLE)
Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure
(General) Drugs and contaminants
of Canola oil Tryptophan procainamide interferon
Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)
Factors Decreasing Risk Breast Fed
Protects against RA and SLE
Past Urinary Tract Infections
Protects against RA
Past Rubella Infection (German Measles)
Protects against RA
Most Common Tissues Affected Red Blood Cells
Pernicious Anemia Hemolytic anemia
Blood Vessels
Vasculitis
Endocrine Glands (Thyroid Adrenal Pancreas)
Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus
Most Common Tissues Affected Muscle Nerve
Multiple sclerosis Myesthenia gravis Joints
Rheumatoid Arthritis SLE Skin and muscle
Dermatomyositis Psoriasis Vitiligo Organ Disease
Digestive system Chronersquos disease Celiac disease Ulcerative
colitis
Generalized SymptomsCommon symptoms
Tissue specific Inflammation and or destruction
Generalize Fatigue dizziness weakness
Possible low Grade Fever
Specific Symptoms
Vary with the individual disease
Most Important General Blood Tests
ESR and CRP
These measure inflammation in the body The numbers rise as tissue destruction becomes more active
Can be used to monitor the condition and assess the success of treatment
Common Western Drug TreatmentImmune Suppressive Drugs
Anti-inflammatory Corticosteroids such as prednisone
Non-steroidal anti-inflammatory drugs
Immune suppressive drugs cyclophosphamide azathioprine cyclosporine
General CourseAs a group they tend to be chronic
Prone to remission and flare -ups
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Factors Increasing Your Risk Cigarette smoking RA+
SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5
years period (Relationship job financial) (RA)
Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral
infections (SLE)
Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure
(General) Drugs and contaminants
of Canola oil Tryptophan procainamide interferon
Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)
Factors Decreasing Risk Breast Fed
Protects against RA and SLE
Past Urinary Tract Infections
Protects against RA
Past Rubella Infection (German Measles)
Protects against RA
Most Common Tissues Affected Red Blood Cells
Pernicious Anemia Hemolytic anemia
Blood Vessels
Vasculitis
Endocrine Glands (Thyroid Adrenal Pancreas)
Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus
Most Common Tissues Affected Muscle Nerve
Multiple sclerosis Myesthenia gravis Joints
Rheumatoid Arthritis SLE Skin and muscle
Dermatomyositis Psoriasis Vitiligo Organ Disease
Digestive system Chronersquos disease Celiac disease Ulcerative
colitis
Generalized SymptomsCommon symptoms
Tissue specific Inflammation and or destruction
Generalize Fatigue dizziness weakness
Possible low Grade Fever
Specific Symptoms
Vary with the individual disease
Most Important General Blood Tests
ESR and CRP
These measure inflammation in the body The numbers rise as tissue destruction becomes more active
Can be used to monitor the condition and assess the success of treatment
Common Western Drug TreatmentImmune Suppressive Drugs
Anti-inflammatory Corticosteroids such as prednisone
Non-steroidal anti-inflammatory drugs
Immune suppressive drugs cyclophosphamide azathioprine cyclosporine
General CourseAs a group they tend to be chronic
Prone to remission and flare -ups
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Factors Decreasing Risk Breast Fed
Protects against RA and SLE
Past Urinary Tract Infections
Protects against RA
Past Rubella Infection (German Measles)
Protects against RA
Most Common Tissues Affected Red Blood Cells
Pernicious Anemia Hemolytic anemia
Blood Vessels
Vasculitis
Endocrine Glands (Thyroid Adrenal Pancreas)
Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus
Most Common Tissues Affected Muscle Nerve
Multiple sclerosis Myesthenia gravis Joints
Rheumatoid Arthritis SLE Skin and muscle
Dermatomyositis Psoriasis Vitiligo Organ Disease
Digestive system Chronersquos disease Celiac disease Ulcerative
colitis
Generalized SymptomsCommon symptoms
Tissue specific Inflammation and or destruction
Generalize Fatigue dizziness weakness
Possible low Grade Fever
Specific Symptoms
Vary with the individual disease
Most Important General Blood Tests
ESR and CRP
These measure inflammation in the body The numbers rise as tissue destruction becomes more active
Can be used to monitor the condition and assess the success of treatment
Common Western Drug TreatmentImmune Suppressive Drugs
Anti-inflammatory Corticosteroids such as prednisone
Non-steroidal anti-inflammatory drugs
Immune suppressive drugs cyclophosphamide azathioprine cyclosporine
General CourseAs a group they tend to be chronic
Prone to remission and flare -ups
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Most Common Tissues Affected Red Blood Cells
Pernicious Anemia Hemolytic anemia
Blood Vessels
Vasculitis
Endocrine Glands (Thyroid Adrenal Pancreas)
Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus
Most Common Tissues Affected Muscle Nerve
Multiple sclerosis Myesthenia gravis Joints
Rheumatoid Arthritis SLE Skin and muscle
Dermatomyositis Psoriasis Vitiligo Organ Disease
Digestive system Chronersquos disease Celiac disease Ulcerative
colitis
Generalized SymptomsCommon symptoms
Tissue specific Inflammation and or destruction
Generalize Fatigue dizziness weakness
Possible low Grade Fever
Specific Symptoms
Vary with the individual disease
Most Important General Blood Tests
ESR and CRP
These measure inflammation in the body The numbers rise as tissue destruction becomes more active
Can be used to monitor the condition and assess the success of treatment
Common Western Drug TreatmentImmune Suppressive Drugs
Anti-inflammatory Corticosteroids such as prednisone
Non-steroidal anti-inflammatory drugs
Immune suppressive drugs cyclophosphamide azathioprine cyclosporine
General CourseAs a group they tend to be chronic
Prone to remission and flare -ups
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Most Common Tissues Affected Muscle Nerve
Multiple sclerosis Myesthenia gravis Joints
Rheumatoid Arthritis SLE Skin and muscle
Dermatomyositis Psoriasis Vitiligo Organ Disease
Digestive system Chronersquos disease Celiac disease Ulcerative
colitis
Generalized SymptomsCommon symptoms
Tissue specific Inflammation and or destruction
Generalize Fatigue dizziness weakness
Possible low Grade Fever
Specific Symptoms
Vary with the individual disease
Most Important General Blood Tests
ESR and CRP
These measure inflammation in the body The numbers rise as tissue destruction becomes more active
Can be used to monitor the condition and assess the success of treatment
Common Western Drug TreatmentImmune Suppressive Drugs
Anti-inflammatory Corticosteroids such as prednisone
Non-steroidal anti-inflammatory drugs
Immune suppressive drugs cyclophosphamide azathioprine cyclosporine
General CourseAs a group they tend to be chronic
Prone to remission and flare -ups
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Generalized SymptomsCommon symptoms
Tissue specific Inflammation and or destruction
Generalize Fatigue dizziness weakness
Possible low Grade Fever
Specific Symptoms
Vary with the individual disease
Most Important General Blood Tests
ESR and CRP
These measure inflammation in the body The numbers rise as tissue destruction becomes more active
Can be used to monitor the condition and assess the success of treatment
Common Western Drug TreatmentImmune Suppressive Drugs
Anti-inflammatory Corticosteroids such as prednisone
Non-steroidal anti-inflammatory drugs
Immune suppressive drugs cyclophosphamide azathioprine cyclosporine
General CourseAs a group they tend to be chronic
Prone to remission and flare -ups
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Most Important General Blood Tests
ESR and CRP
These measure inflammation in the body The numbers rise as tissue destruction becomes more active
Can be used to monitor the condition and assess the success of treatment
Common Western Drug TreatmentImmune Suppressive Drugs
Anti-inflammatory Corticosteroids such as prednisone
Non-steroidal anti-inflammatory drugs
Immune suppressive drugs cyclophosphamide azathioprine cyclosporine
General CourseAs a group they tend to be chronic
Prone to remission and flare -ups
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Common Western Drug TreatmentImmune Suppressive Drugs
Anti-inflammatory Corticosteroids such as prednisone
Non-steroidal anti-inflammatory drugs
Immune suppressive drugs cyclophosphamide azathioprine cyclosporine
General CourseAs a group they tend to be chronic
Prone to remission and flare -ups
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
General CourseAs a group they tend to be chronic
Prone to remission and flare -ups
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
General ComplicationsDisability due to impaired tissue
function
Complications of immune suppression secondary to drugs
Increased incidence of Infections and cancers
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Lymes Disease Microrganism B berdorferi (spirochete type
bacteria)
Cross reactivity
T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Trust the Laws of Nature First Then Trust Science
The Laws of Nature Never Change The Conclusions of Science are always
changing
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Generalized Diagnostic ApproachSeek an understanding of the nidana
Determine the doshic nature of the disease
Understand the samprapti Dhatu and srotas involved
To what degree is ama present
What is the state of ojas
Determine the imbalances of the mind (state of prana-tejas and ojas)
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
The Role of Ama and Dosha
Ama and Dosha combined to enter the dhatu and disturb formation and function
Unstable Dhatu
DhatuAgni
New Dhatu and Upadhatu are
formed
Dhatu agni vitiation results in Amaformation which enters the tissues
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
The Role of Ojas
Ojas is the foundation of a stable immune system
Protects against vitiated dosha and disturbances of prana and tejas
Shukra DhatuTrans-
mutation Ojas
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
The Role of Cellular Intelligence
There is a failure of the intellect on a cellular level resulting in abnormal immune physiology
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
The 3 Keys to protecting ojasaccording to Charaka
The practice of non-violence
Nothing destroys ojas faster than a violent act
Preservation of shukra
The foundation of ojas
Attainment of knowledge
Knowledge of how live harmoniously and nourish ourselves properly
Knowledge of how to sustain the 3 pillars of life
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
The Science of Rasayana The rebuilding of the systems of the body
Follows the three phases of panchakarma
Purva Karma
Pradhan Karma
Praschat Karma
Use of rasayana herbs during praschat karma
Proper lifestyle sustained throughout praschatkarma
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Management of the Annamaya kosha
Rest and Sleep Support a healthy sleep rhythm
Normalize diet and digestion Proper diet in accordance with vikruti
Follow the guidelines for health eating
Create a health daily routine Asana in accordance with onersquos level of ojas
Self abhyanga in accordance with onersquos level of ama
General care practices
Avoid sexual activity
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Management through thePranamaya kosha
Abdominal Breathing
Create a steady healthy relaxed abdominal breathing practice
Pranayama
Choose the proper pranayama based on vikruti
`Minimize if the patient is very weak
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Management through the Manomaya Kosha
Interleukins levels change with emotion
Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )
IL-6 increases when we feel helpless and in pain Pessimism increases inflammation
All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Care for the Manomaya Kosha Balance prana-tejas and ojas
Create a beautiful and supportive sensory environment
Surround yourself with nurturing people with a cheery and positive disposition
Reduce extreme sensory stimuli
Expose yourself to light-hearted stimuli that makes you laugh
Role of a caregiver
Positive Thinking
Yoga Nidra
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Management through theVijnanamaya kosha
Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas
Self- reflection and Inquiry
Expose yourself to inspirational ldquoTruthrdquo based parables and stories
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Management through theAnandamaya kosha
Meditation in accordance with ojas
Realization and the transformation of consciousness
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Yoga and Meditation Yoga and Autoimmune Disease
Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)
Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Lifestyle Yoga and Meditation Complementary therapy use by persons with
multiple sclerosis benefits and research priorities (8)
Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy
25-40 reported that the therapies received were ldquoextremely helpfulrdquo
Authors point to this study to show the potential benefits of CAM procedures for patients with MS
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple
sclerosis (9)
Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with
conventional treatment and high side effects
More positive attitude toward CAM than allopathy
70 use or used at least 1 CAM approach
50+ nutritional supplementation
41 diet modification
26 homeopathy
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Lifestyle Yoga and Meditation Complementary and alternative medicine use in
rheumatoid arthritis in patients in India (10)
Study of 102 patients
82 used CAM therapies
28 used Ayurveda
20 used Homeopathy
17 yoga asana
12 pranayama
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as
treatments for medical illness
Performed University of Connecticut Medical School
Department of Psychiatry (11)
Review of 82 studies of which 20 were randomized controlled studies
Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses
Epilepsy
PMS
Mood disorders
Autoimmune disorders
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To
Make All Their Troubles Go Away
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
General Mechanisms for Herbs Impacting Autoimmune Disease
Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with
autoimmune disease
Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages
Ginger
COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul
Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Transcription Factors Transcription Factor A protein that activates genes
controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)
NF KappaB Nuclear Factor Kappa B cells
Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
The Most Famous Herbs for Rasayana
Vata Pitta Kapha
Amalaki Amalaki Amalaki
Gaduchi Gaduchi Gaduchi
Brahmi Brahmi Brahmi
Ashwaganda
Bala Bala
Haritaki
Bibhitaki
Shallijit
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Well-studied ImmunomodulatorHerbs from India
Turmeric
Gaduchi
Ashwaganda
Boswellia
Castor Oil
Guggulu
Ginger
Kutki
Licorice
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip
hellipNumerous agents derived from plants can suppress these cell
signaling intermediates including curcumin (from turmeric)
hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid
(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment
Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Ashwagandha Latin Withania somnifera
Rasa Sweet bitter astringent
Virya Slightly warm
Vipaka Sweet
Dosha V-PK+ (Ex)
Actions Anti-inflammatory immunomodulator and rasayana
Research
COX-2 inhibitor
Th1 adjuvant useful in chronic infectious disease in immune suppressed patients
Decrease stress Reduced cortisol
Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40
Inhibited transcription factors NFKappaB and Ap-1
Reduces tumor cell proliferation
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-
inflammatory Research COX-2
inhibitor LOX inhibitor Source
Nutr Hosp 2009 May-Jun24(3)273-81
Adv Exp Med Biol 2007595213-26
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen
Hepatoprotective Anti-inflammatory rasayana
Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter
sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory
anti-allergy Research Inhibits
complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-
inflammatory pachana antimicrobial
Research Verification as a COX 12-inhibitor reducing inflammation
httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj
pg
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory
analgesic Research Inflammation
reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana
Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages
Source J Med Food 2010 Feb13(1)156-62
httpdiggingrifileswordpresscom200910ginger2jpg
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Licorice Research
Increases phagocytosis of macrophages
induces IL-1 secretion Enhances NK activity
Enhances mitogen of B-lymphocytes
inhibits viral multiplication
induces IFN production from spleen cells
Reduces post-traumatic inflammation
Reduces mediators of colon cancer (11BetaHSD2)
Raises cortisol levels protecting against inflammation
Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Astragalus Latin Astragalus
membranaceus Part Used Root Action Immune Tonic Research Astragalus
injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments
May work through suppression of IL-6
Pictures httpopenendedquestionfileswordpressco
m200910astragalus-plant1jpg
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Immunomodulator Plants Siberian Ginseng
Latin Eleutherococcussenticosus
Action Adaptogen anodyne immune modulator
Part used Root
Research Higher levels decrease IL-6
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
American Ginseng
Latin Panaxquinquefolius
Part Root
Action Adaptogen tonic anti-cancer
Research Increases natural killer cells
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions
Adaptogen tonic antiinflammatory
Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor
(metastisis) anti-inflammatory
Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions
Shukrajanana shothahara antimicrobial rasayana
Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Immunomodulator Plants
Kutki
Latin Picrorhizia kurrooa
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Anti-inflammatory and immune modulating
Research COX-2 inhibitor
httpwwwgreenchembizproductshtml
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Milk Thistle
Latin Silybummarianum
Action Anti-inflammatory antiviral cholegogue alterative
Rasa Bitter
Virya Cool
Viipaka Pungent
Dosha PK-V+
Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Dandelion Root Latin Taraxacum
officinale
Rasa Bitter
Virya Cool
Vipaka Pungent
Dosha PK-V+
Actions Cholegogue alterative anti-inflammatory
Research
COX-2 inhibitor
Inhibits NFKappaB
Inhibits TNF-alpha
Inhibits IL-1beta
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
General Guidelines for the Management of Autoimmune Disease Vata
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic vata pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (Agni) and elimination (apanavayu)
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
General Guidelines for the Management of Autoimmune Disease
Pitta
Rest and Reduce Stress
Sexual abstinence for at least 30 days
Build ojas
Sattvic pitta pacifying diet
No alcohol coffee
Support Immune system with rasayanas
Support Digestive System (agni) and elimination (pachaka pitta)
Cool and purify the raktavaha srota (liver and blood)
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)
As noted for the primary dosha
Sattvic VK or PK pacifying diet
Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
To Download a Copy of the Slides
Go to California College of Ayurveda
wwwayurvedacollegecom
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Resources 1 Medline Plus Autoimmune Disease
httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease
httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online
httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of
Medicine httppathmicromedscedughaffartolerance2000htm
5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854
International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf
6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31
Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA
8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK
9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany
10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India
bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu
bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005
Resources and References 13 Nature Medicine 5 1375 1999
14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005
15 J Clin Microbiol 43 850 2005