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Psychiatry, Catholic University Hospital, Dae Gu, KoreaCorresponding author.

e investigate the ability and brain activity to recognize affect via emotionalords and facial emoticons in patients with autism spectrum disorders (ASD).

t was a case control study employing ten male adolescents with autism spec-rum disorders and ten, age and sex matched healthy comparison subjects. Brainctivity was assessed using functional magnetic resonance imaging (fMRI) inesponse to emotional words and facial emoticon presentation. Patients withSD have increased activation of fusiform gyrus in response to emotional

spects of words and decreased activation of fusiform gyrus in response to emo-ional meaning in facial emoticons, relative to healthy comparison subjects. Weuggest that patients with ASD are more familiar with word descriptions thanacial expression as depictions of emotion.

ttp://dx.doi.org/10.1016/j.neurenf.2012.04.487

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esults of a randomized controlled trial of speechnterventions for nonverbal preschoolers with ASD. Paul a,∗, I. Tsiouri b, K. Gilbert c

Speech-language Pathology, Sacred Heart University, Milford/CT, USAPsychology, University Hospital of Larisa, Larisa, GreecePschology, Hofstra, Hempstead, USACorresponding author.

his study aimed to assess the relative effectiveness of two interventions on theroduction of first words in prelinguistic preschoolers with ASD. The primaryims of the study were:to compare a direct, speech focused, behavioral intervention with a more natu-

alistic intervention on the production of speech and the adaptive use of verbalommunication in prelinguistic preschoolers with ASD;to examine benefit gained by adding a parent-delivered generalization program

o the clinician-delivered interventions;to examine pre-treatment variables that predicted response to treatment in each

ntervention modality.esults suggest that both interventions, when combined with parent training,ere approximately equally effective in eliciting functional speech; however,retreatment variables associated with improved response to treatment differedor the two approaches. This study was funded by the Autism Speaks Foundationnd by NIDCD Grant K24HD045576.

ttp://dx.doi.org/10.1016/j.neurenf.2012.04.488

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ntranasal oxytocin restrictively improves emotionecognition for men with autism spectrum disorders. Yamada ∗, H. Ohta , H. Watanabe , C. Kanai , M. Tani , T. Ohno ,. Takayama , A. Iwanami , N. Kato , R. Hashimoto

Neuropsychiatry, Showa university school of medicine, Tokyo, JapanCorresponding author.

bjective.– Individuals with autism spectrum disorders (ASDs) are impaired innderstanding social cues and responding to them. Face-processing and emotionecognition impairments have especially been confirmed by cognitive, behavio-al, and neuroimaging studies. Recent study shows intranasal oxytocin improveshe score of the Reading the Mind in the Eyes Test (RMET) in youth with ASDs.

e explore whether the effectiveness of oxytocin is also applied to JapaneseSDs.ethod.– In a single-blind, randomized, placebo-controlled, crossover design,e gave oxytocin nasal spray (24IU) or a placebo to 19 men with ASDs. Parti-

ipants then completed the RMET, a widely used test of emotion recognition.esult.– Compared with placebo, oxytocin administration only improved thecore of difficult items of RMET. However, there was no significant difference

n easy items and all items.onclusion.– The effectiveness of oxytocin on RMET is restricted to difficult

tems in Japanese ASDs.

ttp://dx.doi.org/10.1016/j.neurenf.2012.04.489

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l’enfance et de l’adolescence 60S (2012) S197–S253 S219

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haracteristics of antisocial behaviour by ASD adolescentsn the Tokyo district. Fujikawa

Faculty Of Psychology, Kyoto Notre Dame University, Kyoto, Japan

n Japan, a juvenile, a person under 20 years of age, who has committed anffence, is subject to a hearing of the family court. The family court has familyourt probation officers, experts in psychology and pedagogy, who work togetherith judges to examine background of cases of juvenile delinquency. Japan has

he one of the lowest crime rates among industrial countries. Juvenile crimeseaked in 1983 after the Second World War, and it seems that their characteristicsave gradually changed since the early 2000s.While crimes relating to antisocialse of motorcycles have faded, socially inept delinquents have emerged. At thisongress, I will introduce the results of a study on the frequency of developmentalisorders, conducted in the Tokyo Family Court, and discuss gender, the typesf crimes committed and what triggered delinquency in the 32 cases of ASDnvestigated.

ttp://dx.doi.org/10.1016/j.neurenf.2012.04.490

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utism spectrum disorders (ASD) and attentioneficit/hyperactivity disorder (ADHD): The problem ofomorbidity and different diagnostic. Martsenkovskyi

Medical Department No 1, O.O. Bogomolets National Medical University,yiv, Ukraine

ntroduction.– The Main of this study is to identify using scientifically validatediagnostic tools the percentage of children with ASD and ADHD in a sampleith polymorphic symptoms.ethod.– We evaluated a sample of 226 children 3-7 years old. For diagnos-

ic we applied ADI-R (Autism Diagnostic Interview Revised) and ADHD-RSAttention Deficit Hyperactivity Disorder–Rating Scales). We also used PEP-

(Psychoeducational Profile Revised), Ritw-Freeman and Vineland Adaptiveehavior Scales, Second Edition (Vineland II).esults.– After applying a diagnostic tool (ADI-R and ADHD-RS) on a patientith polymorphic symptoms, we obtain the following results: 22.1% of the

ample was diagnosed with Autism Disorders; 13.3% with Autism NOS and4.6% with Language Development Delay (LDD). ADHD was complied withutistic disorders 64.0%, with ASD in 68.3% of cases and in 25% of casesith LDD. There is a significant correlation between ADI-R and ADHD RS

cores; ADI-R and Hyperactivity ADHD-RS scores. There is not a significantorrelation between ADI-R and Inattentive ADHD RS scores.onclusion.– Inattention and hyperactivity are displays of different clinicalariants of ASD.

ttp://dx.doi.org/10.1016/j.neurenf.2012.04.491

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evelopment of TEDIS, an information system dedicatedo patients with pervasive developmental disorder. BenSaid , E. Vion , A. Ghazaly , B. Golse , P. Landais , L. Robel ∗

Child And Adolescent Psychiatry Department, hôpitalecker-Enfants–Malades, Paris, FranceCorresponding author.

utism is a developmental disorder included in the category of pervasive deve-opmental disorders (PDDs) characterized by a huge heterogeneity in terms ofange of severity, evolution, and etiology. The creation of expert centers in theiagnosis and the evaluation of PDDs in France (CRA) has improved their recog-ition. They collect important data concerning history, familial characteristics,ognitive and developmental functioning of the patients, as well as the resultsf medical investigations.

ethodology.– We have developed an innovative information system devoted

o PDDs called TEDIS, designed to easily integrate PDD expert assessments inultiple centers.