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Auditory Processing. Physical Dimension Perceptual Dimension. AmplitudeLoudness FrequencyPitch ComplexityTimbre. 05-34. W. W. Norton. 05-33. W. W. Norton. 05-36. W. W. Norton. 05-37. W. W. Norton. Mapping the Auditory System in Rhesus Monkeys. Neuroscience Program. - PowerPoint PPT Presentation
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Auditory Processing
Physical Dimension Perceptual Dimension
Amplitude Loudness
Frequency Pitch
Complexity Timbre
W. W. Norton
W. W. Norton
W. W. Norton
W. W. Norton
Mapping the Auditory System in Rhesus
Monkeys
University of Iowa
NeuroscienceProgram
The University of IowaDepartment of Psychology
Behavioral and Cognitive Neuroscience
Visual Processing Streams
25
“WHAT”
“WHERE”
24
Auditory cortexUnfolded view of
supratemporal plane and adjoining STG.
BeltParabelt
Core
Kaas and Hackett, PNAS 2000
Auditory Projection System
Lower Brainstem
Lower Brainstem
IC
MGB
IC
Early Auditory
Areas
MGB
Early Auditory
Areas
Auditory Projection System
Lower Brainstem
Lower Brainstem
IC
MGB
IC
Early Auditory
Areas
MGB
Early Auditory
Areas
Corpus Callosum,Anterior & Posterior
Commissures
Tectal Commissures
Lower Brainstem
Lower Brainstem
MGB
Early Auditory
Areas
MGB
Early Auditory
AreasForebrain Comm.
Tectal Comm. ICIC
Intact side 'Deaf' side
Methods
Speakers 2-DG injected intravenously
Monkey listens passively for 45 min
Wide variety of acoustic stimuli
Brain prepared for autoradiography
LCGU measured in ROIs throughout brain
ROIs compared for hemispheric asymmetries
Three surgically prepared monkeys
Auditory StimuliPassive Listening
BIRDS (10%)
ENVIRONMENTAL (18%)
HUMAN (9%)
MONKEYS (31%)
MUSIC (12%)
OTHER ANIMALS (8%)
TONES, SWEEPS, NOISE (12%)
29
2 DG in Intact (left) and Deafferented (right) Hemisphere
Early auditory areas
MGB
IC
A15
“Hearing” “Deaf”
30
31 Poremba et al., Science, 2003
Columns of 2DG activation in rSTG
Hearing Side of Deafferented Monkey
Completely Intact Monkey
32 Poremba et al., Science, 2003
Metabolic Mapping of Visual Cortex
Metabolic Mapping of Auditory Cortex
Overlap of Auditory and Visual Maps
Similar Auditory and Visual Processing Streams
57
“What”
“Where”
35
Left Hemisphere Right Hemisphere
Superior Temporal Gyrus (STG)(n=7 monkeys)
12
34
5
% o
f W
ho
le B
rain
Act
ivit
y
Monkey Vocalizations
Complex Sounds and Vocalizations
Complex Sounds No Vocalizations
Ambient Background Sound
70
80
90
100
110
120
130
Human Vocalizations
High
Low
High
Low
Monkey Vocalizations
p<0.001
*
Complex Sounds and
Vocalizations
p<0.01
*
FDG Activity in the Dorsal Temporal Pole
70
80
90
100
Ambient Background
Noise
% o
f W
ho
le B
rain
Ac
tivi
ty
Left Hemisphere Right Hemisphere
Monkey Vocalizations
p<0.001
*
Complex Sounds and
Vocalizations
p<0.01
*
FDG Activity in the Dorsal Temporal Pole
70
80
90
100
Ambient Background
Noise
Left Hemisphere Right Hemisphere
Complex Sounds No Vocalizations
% o
f W
ho
le B
rain
Ac
tivi
ty
70
80
90
100
Ambient Background Sound
Monkey Vocalizations
% o
f W
ho
le B
rain
Ac
tivi
ty
p < 0.001
*
MonkeyVocalizations
Split BrainMonkeys
Left Hemisphere Right Hemisphere
Dorsal Temporal Pole (n=8 intact monkeys, n=3 split brain monkeys)
44 Poremba et al., Nature, 2004
Similar Auditory and Visual Processing Streams
57
“What”
“Where”
Parabelt projections to prefrontal cortex
Romanski et al., Nature Neuroscience, 1999
