Auditory Neuroscience 1 Spatial Hearing Systems Biology Doctoral Training Program Physiology course Prof. Jan Schnupp jan.schnupp@dpag.ox.ac.uk HowYourBrainWorks.net

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  • Auditory Neuroscience 1Spatial HearingSystems Biology Doctoral Training ProgramPhysiology course

    Prof. Jan Schnuppjan.schnupp@dpag.ox.ac.uk

    HowYourBrainWorks.net

  • Hearing: an impossible task!

  • http://auditoryneuroscience.com/foxInSnow

  • Interaural Time Difference (ITD) CuesITDs are powerful cues to sound source direction, but they are ambiguous (cones of confusion)

  • Front-Back Ambiguity and Phase Ambiguityhttp://auditoryneuroscience.com/ear/bm_motion_2

  • Interaural Level Cues (ILDs)Unlike ITDs, ILDs are highly frequency dependent. At higher sound frequencies ILDs tend to become larger, more complex, and hence potentially more informative.ILD at 700 HzILD at 11000 Hz

  • Spectral (Monaural) Cues

  • Adapting to Changes in Spectral CuesHofman et al. made human volunteers localize sounds in the dark, then introduced plastic molds to change the shape of the concha. This disrupted spectral cues and led to poor localization, particularly in elevation. Over a prolonged period of wearing the molds, (up to 3 weeks) localization accuracy improved.

  • EI neuron

  • Phase locking improves in the cochlear nucleusSpherical bushy cellEndbulb of HeldAuditory nerve fiber

  • EE neuron

  • The Jeffress model: mapping ITDs in the brain?http://auditoryneuroscience.com/topics/jeffress-model-animation

  • ITD tuning varies with sound frequency: no map?

  • The Auditory PathwayCN, cochlear nuclei; SOC, superior olivary complex; NLL, nuclei of the lateral lemniscus; IC, inferior colliculus; MGB, medial geniculate body.

  • Lesion Studies Suggest Important Role for A1Jenkins & Merzenich, J. Neurophysiol, 1984

  • Binaural Frequency-Time Receptive Field

  • Linear Prediction of ResponsesFrequency [kHz]r(t) = i1(t-1) w1(1) + i1(t-2) w1(2)+ ... + i2(t-1) w2(1) + i2(t-2) w2(2)+ ...+ i3(t-1) w3(1) + i2(t-2) w3(2)+ ...

    LatencyFTRF w matrixInput i vector

  • Left and Right Ear Frequency-Time Response FieldsVirtual Acoustic Space StimuliFrequency [kHz]acdefbElev [deg]Predicting Space from SpectrumSchnupp et al Nature 2001

  • Higher Order Cortical AreasIn the macaque, primary auditory cortex(A1) is surrounded by rostral (R), lateral (L), caudo-medial (CM) and medial belt areas. L can be further subdivided into anterior, medial and caudal subfields (AL, ML, CL)

  • Are there What and Where Streams in Auditory Cortex?Some reports suggest that anterior cortical belt areas may more selective for sound identity and less for sound source location, while caudal belt areas are more location specific.It has been hypothesized that these may be the starting positions for a ventral what stream heading for inferotemporal cortex and a dorsal where stream which heads for postero-parietal cortex.Anterolateral BeltCaudolateral Belt

  • A Panoramic Code for Auditory Space?Middlebrooks et al. found neural spike patterns to vary systematically with sound source direction in a number cortical areas of the cat (AES, A1, A2, PAF).Artificial neural networks can be trained to estimate sound source azimuth from the neural spike pattern.Spike trains in PAF carry more spatial information than other areas, but in principle spatial information is available in all auditory cortical areas tested so far.

  • Artificial Vowel SoundsBizley et al J Neurosci 2009 29:2064

  • Responses to Artificial Vowels in SpaceBizley et al J Neurosci 2009 29:2064

  • Azimuth, Pitch and Timbre Sensitivity in Ferret Auditory CortexBizley et al J Neurosci 2009 29:2064

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