ATI NEUROSTIMULATION

SYSTEM:

Presentation by: Sarah

Borges

Electronic Aspirin

Known commonly as “Electronic aspirin”

Only one company developing this device- ATI

Consists of 2 separate pieces

• Remote control

• Implantable device

Designed to treat cluster headaches

ATI NEUROSTIMULATION SYSTEM

Also known as “suicide” headachesCondition of severe unilateral temporal/orbital painHeadaches last 15 min-3 hoursSymptoms include:

• Watery eyes• Droopy eyelid• Nasal congestion• Localized swelling

Associated with the SPG (sphenopalatine ganglion) bundleAffects 0.2% of United States population

CLUSTER HEADACHES

Oxygen treatment with a tank• Cumbersome

Oral medication• Run the risk of an allergic reaction

Sphenopalatine ablation• Killing local SPG area via heat

• Last resort: can lead to partial facial paralysis

OTHER TREATMENT METHODS

Two separate parts:• Device

Almond-sized 2 terminals

• Remote control Hand-held, rechargeable

Upon onset of headache, patient places remote to device, sending electrical signal to device

Device stimulates SPG bundle in a way that prevents the release of pain-related neurotransmitters

ATI SYSTEM DESIGN

Surgery is about as extensive as removal of wisdom teeth

• ~1-3 hours in length

Device is implanted on the side of the head patient experiences headaches more: within gum tissue, below eye

IMPLANTATION PROCEDURE

System still in clinical trial phase• Currently testing device on 120 patients since

• Will continue monitoring patients for one year

Preliminary results:• 75% patients have recorded improvement in their ability to

function normally in their daily lives

• 68% report experiencing less severe headaches

• 31% report a decrease in the amount of headaches they have weekly

CURRENT RESULTS

Less bulky/more conspicuous than an O2 tank

Does not risk patient having an allergic reaction or conflicting prescriptions for other health implications

Unlike ablation, ATI system has temporary effects• ATI system can be removed if need be

BENEFIT OF ATI SYSTEM OVER OTHER TREATMENTS

More difficult to stop treatment than O2 tank/oral medications: need surgery to remove

Can only treat one side of head

Have to remember to charge remote control and bring everywhere

Electronic device: has the potential to malfunction

Only treatment for patients of cluster headaches

FORESEEN DISADVANTAGES

FDA approval

Design to make available to patients suffering from migraines, tension headaches, and other types of facial pain due to other conditions they may have

FUTURE DIRECTION

Bahra, Anish, et al. "Cluster Headache: A Prospective Clinical Study with Diagnostic Implications." Neurology58.3 (2012): 354-61. Neurology. Web. 2 Nov. 2014

Sphenopalatine Ganglion Stimulation for the Treatment of Chronic Cluster Headache<http://clinicaltrials.gov/ct2/show/

results/NCT02168764?term=autonomic+technologies> Electronic Aspirin <http://www.bibalex.org/psc/en/home/

sciplanetdetails.aspx?id=104> Wikipedia: Cluster Headache <http://en.wikipedia.org/wiki

/Cluster_headache> Zapping the Sphenopalatine Ganglion <http://www.clusterattack.com/blog/zapping-the-

sphenopalatine-ganglion/ "News Europe: Neurostimulation: Gingival Implant Helps Reduce Cluster

Headache." RSS. Dental Tribune International, 6 Mar. 2014. Web. 12 Nov. 2014. Hanna, M. "Migraine Headaches, Tension Headaches, and Cluster Headaches." Dr. M.

Hanna, n.d. Web. 10 Nov. 2014. <http://drmhanna.com/migraine-headaches-tension-headaches-and-cluster-headaches/>.

REFERENCES