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AT A GLANCE
DR. JOHN. K.J. THARAKAN - MBBS. MD.DM.FRCP. FAAN.
Gold Medallist and Rank holder for MBBS.
Awarded the prestigious “Commonwealth Fellowship” 1987-88.
Elected Fellow of American Academy of Neurology. 1998
Elected Fellow of Royal College of Physicians of Ireland-2002
Started for the first time in Malaysia’ Advanced Masters In Medicine-Neurology” course.
Established “Epilepsy Surgery Programme “in HUSM.
Started for the first time “Deep Brain Stimulation” for Parkinson’s disease in HUSM
Awarded “ANUGERAH PERKIDMATAN CEMERLANG”USM 2004
29 years of full time teaching experience, at undergraduate and postgraduate level.
Examinership at undergraduate level and postgraduate level
Delivered lectures at several C.M.E. Programs.
Actively participated in various National and International Conferences.
Attended C.M.E. courses offered by International Professional Organizations.
Received the “Best Paper Award” at a National level conference.
Several publications in peer reviewed journals.
Member Board of referees of international journals- J.Ind.Acad.Neurol, J.Ped.Neurol.
Engaged in various Clinical Research Activities and conducted Clinical trials
29 years of experience in clinical Neurology/Neurointensive care/Neurophysiology/ Internal
Medicine
Experience in organizing and developing Neurology services and training programs in
different institutions.
CURRICULUM. VITAE.
NAME JOHN THARAKAN. K.J.NATIONALITY: IndianDATE OF BIRTH: 01 October 1951
MAILING ADDRESS: Professor & Senior Consultant Neurologist Department of Neuroscience, School of Medical Sciences, University Sains Malaysia16150-Kubang-Kerian, Kelanton, Malaysia
TELEPHONE NUMBER: Office 60-9-7664216Residence. 60-12-9591840Fax: 60-9-7664216E-mail: [email protected]
PROFESSIONAL QUALIFICATIONS
1973 M.B.B.S. Medical College, Kottayam Univ:of Kerala, India
1978 M.D. MEDICINE Medical College, Trivandrum Univ:of Kerala, India
1981 D.M. NEUROLOGY All India Institute of Medical Science, Delhi, India
1998 F.A.A.N. Corresponding Fellow American Academy of Neurology
2002 F.R.C.P. Fellow Royal College of Physicians of Ireland.
AWARDS AND GOLD MEDALS
1. First Rank and Gold Medal for Medicine, University of Kerala
2. First Rank and Gold Medal for Ophthalmology, University of Kerala
3. Third Rank for M.B.B.S., University of Kerala
4. E. Merck Award and Gold Medal for Neurology 1985 for the best scientific paper presented at the annual conference of -Neurological Society of India.
5. Awarded “ANUGERAH PERKIDMATAN CEMERLANG”USM 2004
FURTHER TRAINING
1. Neuroimmunology Fellowship. August1987- September 1988.Awarded Commonwealth Fellowship and had further training in Neurology and Neuroimmunology under Prof. R.A.C. Hughes, M.D.FRCP and Dr. M.D. O'Brien M.D. FRCP in the Department of Neurology, Guy's Hospital, London. Undertook both clinical and research work.
2. Short Course on Practical Statistics for Medical Research. 18-22 January 1988Attended this training programme on Research Methodologies and Statistical Applications in Medicine, conducted by the Royal Post-Graduate Medical School, London
3. Workshop on “Effective Postgraduate Teaching and Assessment”. August. 14-15 2002
Conducted by University Sains Malaysia in July 2002. This course offered training in various teaching and assessment tools, currently used in Postgraduate Medical Education.
4. Short course on “ Good Clinical Practice”. October 6-8. 2002Attended this short course on GCP guidelines for conducting clinical trials and clinical research, organized by University Sains Malaysia, in October 2002.
5.Transcranial Doppler Training. October 13-14. 2002. Organised by the Neurosains Unit of University Sains Malaysia. It was conducted as a “Hands on” training workshop.
6. Ethics in Medical and Health research. 28-29.July 2004. Two-day workshop organised by U.S.M. and conducted by Dr Emma Williamson, Univ: Bristol, U.K.
CME COURSES ATTENDED.
Sleep Disorders. Half-day course conducted by World Federation of Neurology. September.1997. Buenos Aires
Immunomodulation in Neurological disorders. Half-day course conducted by World Federation of Neurology. September 1997. Buenos Aires
Update on Neuromuscular disorders. Half-day course conducted by American Academy of Neurology, April 1999. Toronto.
Parkinson disease-Therapy. CME course conducted by American Academy of Neurology, April 1999. Toronto.
Stroke - Therapy. CME course conducted by American Academy of Neurology, April 1999. Toronto.
Epilepsy-Therapy. CME course conducted by American Academy of Neurology, April 1999. Toronto.
Treatment issues-Evidence based Epilepsy treatment.- EUREPA Teaching Seminar. 29-08-05. 29th IEC. Paris
Neurology Update. 1 and 2 . Full day CME course conducted by American Academy of Neurology on 30-04-07 and 04-05-07. Boston-USA.
Deep Brain Stimulation for Parkinson’s Disease. CME programme conducted by American Academy of Neurology on 05-05-07. Boston-USA.
CME LECTURES DELIVERED.
1."Etiological Concepts in M.N.D". At the National Seminar on Recent Advances in Neurosciences”, Trivandrum 1983.
2."Inflammatory Polyneuropathies" at the Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, U.S.A. June 1988.
3."Immunology of Acute Inflammatory Polyneuropathy” At the Workshop on "Neuroimmunology" conducted by the National Institute of Immunology New Delhi, February 1990.
4.Several lectures on “recent advances in neurology” at the yearly Neurology Update Seminars organized by Sri Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum India between 1984-91.
5.“Plasmapheresis in Neurology". At the International Update Session on Neurosciences, Muscat, December 1991.
6.“Recent advances in Guillain Barre Syndrome” CME at Nizwa Hospital. Oman March 1992.
7.“Role of EMG and Nerve Conduction Studies in clinical practice” At Khoula Hospital, Oman. 1993.
8.“Treatment of Seizure disorders” CME at Emergency Medicine Dept: Royal Hospital Oman. 1994.
9.“Principles of management of Epilepsy” At Khoula Hospital, Muscat Oman. 1995.
10.“Treatment of refractory epilepsy” At the Neurology update seminar. Royal Hospital, Muscat, 1997.
11.“General principles of management of Stroke.” CME Nizwa Hospital, Oman. 1999.
12.“Modern trends in Stroke management” CME at Sohar Hospital Oman. 2000.
13.“Stroke-Current concepts of management” and “Treatment of refractory epilepsy” At the 2 day course on “Neurology for the General Practitioners” July 2002. Organized this course at University Sains Malaysia.
14.“GBS-What is new?” And “Recent Advances in Disorders of Neuromuscular Junction” At the National Postgraduate Neurology Update Seminar, University Kebagsan Malaysia. Kuala Lumpur. July 16-19.2002.
15.“Diagnostic approach to Peripheral Neuropathy” and Mitochondrial Myopathy”. At
the National Post Graduate course-Neurology Update-2003. February15-
16Organized this course at University Sains Malaysia and also conducted the
clinical interactive sessions during this course
16. National conference on “Neurocritical care” – University Sains Malaysia. 4-5 September 2004. Gave 2 lectures- “Approach to unconscious patient” and “Acute flaccid Paralysis”
17. Stroke in the context of Interventional Radiologist. Lecture delivered at the 3rd Neurointerventional Seminar – USM. 09-08-2005
18. Stroke- An Evidence based Treatment. Invited talk at MMA-Kelantan meeting. March-2006.
19. Approach to headache in Emergency department. Lecture given at the 2nd National Congress of Emergency Medicine. USM Malaysia. 26-11-2006.
20. Ischaemic Stroke- Advances in the past decade and what is in store for the future. Lecture delivered at the First Scientific Meeting of Surgical neurology trainees of Malaysia- Johor- 25-11-2006.
MEMBERSHIP IN PROFESSIONAL ORGANIZATIONS
1. Association of Physicians of India
2. Neurological Society of India
3 American Academy of Neurology.
4 Royal College of Physicians of Ireland
5 Malaysian Society of Neurosciences
MEDICAL REGISTRATION
1. Travancore Cochin Medical Council. Trivandrum, Kerala- (State Medical Council under the Indian Medical Council)- Registration Number-6913-Dated 5th October 1974
2. Malaysian Medical Council (Ministry of Health, Kula Lumpur, Malaysia). Registration Number-37637 dated 4th May 2004.
3. Limited Registration with General Medical Council (153 Cleveland St; London W1P6DE). Registration Number-87/0788.dated 8th September1987.
1.
CLINICAL-EXPERIENCE
Year Position Field of Work Place of Work
Aug1974 -Aug 75
Feb.1976 - March 1978
Jan.1980 – Jan 1982
Feb.1979 –July.1985
July.1985 – Jan.1986
Aug.1987 - Sept. 1988
Jan.1986 - Sept. 1991
Sept.1991 - April.2002
May.2002 – April 2008
May 2008- till date
Junior Resident-
Junior Resident
Senior Resident
Lecturer
Assistant Professor
Clinical Fellow
Associate Professor
Assistant Professor
Associate Professor
Professor
Medicine
Medicine
Neurology
Neurology
Neurology
Neurology/Neuroimmunology
Neurology
Medicine/Neurol
Neurology
Neurology
AIIMS, New Delhi, India
Med: Coll: Hosp: Trivandrum
AIIMS, New Delhi, India
Sri Chitra Tirunal Institute for Medical Sciences and TechnologyTrivandrum, India
SCTIMST, Trivandrum, India
Guy’s Hospital. London
SCTIMST, Trivandrum, India
S.Q.University, Muscat, Oman
Univ.Science.Malaysia
Univ.Science.Malaysia
Sri Chitra Tirunal Institute for Medical Science and Technology. Trivandrum. India (http://www.sctimst.ac.in)
February 1979 – September 1991.
S.C.T.I.M.S.T. is a tertiary level referral centre, catering to a population of 25 million, and it is declared as a University and an Institute of National Importance by an act of Indian Parliament. I joined this institute as a full time faculty member in February 1979 and worked there till September 1991. I was second in position in the hierarchy of neurology department.
Neurology services have 50 inpatient beds with an ICU dedicated exclusively for their patients. This is complemented by the Neurosurgery department having similar bed strength and ICU facilities, and supported by a Neuroradiology division with facilities for CT scanning, MRI scanning, Digital Subtraction Angiography and Myelography, a Neuropathology division having facilities for all types of histopathological, immunopathological and electron microscopic studies and a neurochemistry division offering various neurochemical assays. The Neurophysiology laboratory has facilities for digital EEG and brain mapping, 24-hour EEG video monitoring; multimodality evoked potential studies, EMG and nerve conduction studies.
The department conducts 5 neurology clinics and 3 special clinics for epilepsy, headache and neuromuscular disorders in a week and offered advanced treatment facilities for all types of neurological problems. Twenty-five new cases are scheduled in a single neurology clinic, and an average of 850-900 new cases are admitted annually to neurology wards. I conducted 2 general neurology clinics and one neuromuscular clinic in a week. In addition to the routine clinical neurological activities, I was in charge of Neurology ICU and 1065 patients were treated in NICU between 1st January 1981 and 31st December 1990. Plasmapheresis, critical care neurology, interventional neuroradiology for vascular malformations of brain and surgery for epilepsy and movement disorders, are some of the specialized clinical services offered by this centre. I was in charge of Plasmapheresis programme, which was offered to Acute GBS and in selected indications of Myasthenia patients. Our department was one of the early centres in India offering Thymectomy for Myasthenia Gravis and I was instrumental in starting this way back in 1982.
I have gained extensive experience in performing and reporting Neurophysiological investigations. On an average 1400-1500 EEGs, 300-350 NCS/EMG studies and 400-450 EP studies were performed annually in the Neurophysiology labs and 2 – 3 Neurologists shared this workload. Consultants took on call duty once in 3 days for most part of my stay and at times once in 2 days. There are weekly Neuroradiological conferences on every Saturday morning and Neuropathology meeting /brain cutting sessions every Saturday afternoon. I was member of the Library Committee and Junior Staff Selection Committee during varying periods of my tenure.
Sultan Qaboos University, College of Medicine, Muscat, Oman (www.squ.edu.om/)September 1991- April 2002.
This is the only medical school in this country and the University hospital is the apex referral centre here. I joined the division of Neurology - Department of Medicine, from the very beginning of the department in September 1991,and was actively involved in the organization and development of neurology services and training in that country. The neurology division has all modern facilities and offers tertiary level service to the entire country. Neurophysiology Laboratory facilities include EMG and nerve conduction studies, digital EEG and video monitoring, 24-hour EEG recording, polysomnography and electronystagmography. Neuroradiology facilities include CT scanner, MRI, digital subtraction angiography and myelography. There were 3 Neurologists in the Unit.
The neurology unit conducts 3 outpatient clinics in a week and the average booking for a day was 25-30 patients. Neurology clinics were conducted at two regional hospitals in Nizwa and Sohar once a month. Annual neurological admissions ranged between 250-300 patients. I did on call rota with general physicians on a 1 in 6 scale and also gave on call cover for emergency neurology admissions once in 3 days. Neurology consultation service was provided to other departments on a regular basis. On an average 1200-400 EEGs were performed annually. Statistics for other Neurophysiological procedures are tabulated below.
I was a member of the Medical records Committee during 1995-98.
TEST NCS EMG 1990 1831991 2131992 3111993 436 841994 503 1221995 565 1261996 524 821997 592 721998 701 661999 618 332000 637 34
Total 5283 619 5902
Test BAEP VEP SSEP1990 49 34 131991 205 27 21992 482 73 341993 336 189 1111994 340 149 1091995 353 126 1291996 257 97 1251997 74 48 511998 212 137 1271999 240 153 762000 255 152 95
Total 2803 1185 872 4860
Department of Neurosciences- School of Medical Sciences-University Sains Malaysiawww:medic.usm.my/dept/neuroscience Since May 2002
The Unit of Neurosciences at the University Sains Malaysia is comprised of Neurology, Neurosurgery and allied supporting specialties like Neuroradiology, Neuropathology etc: and I am the Chief Neurologist in the Unit. This is a tertiary level referral centre for neurological disorders in the eastern part of peninsular Malaysia, equipped with all modern facilities. There is a 6-bedded dedicated ICU for Neurosciences. Neurophysiology Laboratory facilities include EMG and nerve conduction studies, digital EEG and video monitoring, 24-hour EEG recording, polysomnography and electronystagmography. Neuroradiology facilities include CT scanner, MRI, digital subtraction angiography and SPECT. There are 2 general neurology clinics in a week and the average booking per clinic is 40-50 patients. Yearly neurology admissions are in the region of 230-250 patients. Neurology consultation service is provided to other departments on a regular basis. The volumes of Neurophysiological testes are 900-1000 EEGs, 100-125 NCS/EMG and 150-200 EP’s annually. There are weekly neuroradiology conferences and monthly neuropathology meetings. I drew up the protocol for Thrombolysis in Stroke and this treatment is offered at this unit since 2003. I also drafted the Epilepsy Surgery Protocol and we have started Epilepsy surgery programme here since July 2004. In 2006 we started D.B.S. for movement disorders for the first time in HUSM.
PRACTICALS- CLINICAL (PER YEAR)
Institution. SCTIMST (78-91). SQU Muscat (91-02). USM (02)
1. Outpatients 3500/year 1500/year 1500-2000/yr
2. Inpatients 800-900/Yr 300-350/Yr 300-350/yr
3.Critical care 150-75/Yr 50-70/Yr 100-125/yr
4.EEG, VEEG. 1200/Yr 1200/Yr 900-1000/Yr
5.NCS/EMG 350-400/Yr 450-500/Yr 100-125/Yr
6.Evo.Poten: 400-425/Yr 400-450/Yr 150-200/Yr
CLINICAL PROTOCOLS DEVELOPED.
1. HUSM guidelines for “Thrombolytic therapy in acute stroke”
2. Protocol for “Evaluation of refractory epilepsy patients and Surgical treatment for Epilepsy”
3. Protocol for “Deep Brain Stimulation for Movement Disorders “
4. Protocol for “Management of Hypertensive Intracranial haemorrhage”
5. Protocol for “Treatment of spasticity with Baclofen Pump “
TEACHING-EXPERIENCE
SRI CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCE AND TECHNOLOGY. INDIA (http://www.sctimst.ac.in) February 1979 – September 1991.
The department conducts Neurology Residency Program of 3 years duration, leading to Doctorate in Medicine (D.M.) in Neurology. I was actively involved with the organization and running of this residency program from the very beginning. The entry requirement is Masters degree in Internal Medicine, Psychiatry or Paediatrics. Candidates were selected based on their performance at the entrance examination and interview.
The residents undertook supervised clinical responsibilities with more autonomy in decision making as they progressed through their training. There are dedicated teaching activities in the form of bedside teaching rounds, PG case discussions, Journal clubs, Seminars /Tutorials, Clinical Neurophysiology training sessions, weekly Neuroradiology and Neuropathology conferences and few didactic lectures on basic neuroscience topics. The residents also gained experience in clinical research when they undertook at least one research project during their training period. I regularly conducted all of the teaching activities listed above and supervised resident’s research projects.
There are periodic internal assessments as well as two examinations-one at the end of year 1 for basic neurosciences and the other at the end of year 3, consisting of written, clinical and viva components. 22 neurology residents were trained during my tenure. Their list can be found at http://www.sctimst.ac.in/alumni/neurology/htm
Neurology training was also offered to Internal Medicine, Paediatrics and Psychiatry residents who rotated through our department as part of their residency program. Continuing Medical Education Courses in Neurology were also conducted periodically, targeting the general practitioners and internists in the state.
SULTAN QABOOS UNIVERSITY, COLLEGE OF MEDICINE, MUSCAT, OMAN ( http://www.squ.edu.om/ ) September 1991- April 2002.
The division of neurology is actively involved in both undergraduate and postgraduate training programs. Undergraduate training is mainly in the form of bedside clinical teaching, problem-based teaching of major neurological problems and integrated lecture series covering all the neurological topics. As the Coordinator of
1. Junior rotation of medical students in the Department of Medicine. I was responsible for their overall posting in Medicine, timetabling, conducting the end of rotation examination, verification of log books and evaluation of training programme.
2. “Introductory week in Clinical Medicine”. Students start their clinical rotations from year5 onwards. During this week they are introduced to etiquettes of clinical medicine, history taking and proper techniques
of performing a thorough clinical examination of different systems. I was responsible for running this programme Specific Teaching activities. Bedside clinical teaching of Year 5 and 7 students Direct supervised training of 7th year (final year) students posted to the unit Problem based teaching of 7th year students Data interpretation session with year 5 students
Problem based teaching –year 5 students- Neurology, Cardiology, Respiratory medicine and Infectious diseases. Neurophysiology teaching –year 7 students- during their interdisciplinary week posting in Clinical physiology laboratories
Post Graduate Teaching.
Residents from Medicine, Psychiatry, Family Medicine and Ophthalmology have their rotation in NeurologyPostgraduate training included case discussion, seminars, journal clubs, clinicopathological meetings and other interdisciplinary meetings.
On an average 20 hours were spent in teaching per week. I was also an Examiner for various in course assessments as well as for the final exit examination
DEPT: OF NEUROSCIENCES- SCHOOL OF MEDICAL SCIENCES-UNIVERSITY SAINS MALAYSIA . ( http://www.medic.usm.my/dept/neuroscience /) Since May 2002
Neuroscience unit is responsible for providing Neurology input to both undergraduate and postgraduate training programme. Undergraduate programme at U.S.M follows the Problem Oriented Learning module. Postgraduate programme offers 4-year M.Med degree. At present, residents from Medicine, Emergency Medicine, Psychiatry, Family Medicine and Ophthalmology have their rotation in Neurology. Our unit has started the M.Med Neurosurgery course in 2001, the only centre to offer this programme in Malaysia. Similarly, for the first time in Malaysia, Advanced Masters Degree course in Neurology was started in our department in June 2007. I was responsible for drafting the course objectives and curriculum and piloting it through various university bodies.
Member of the PPSP MD Curriculum revision work shop held at Cameroon Highlands from 9-11 March 2006.
Member of the Task Force on “Delivery of Teaching and Learning”
UNDERGRADUATE TEACHING.
Bedside clinical teaching 4th and 5th (final) year students
Tutorials for 4th and 5th (final) year students
Problem based Learning- Nervous System Block
Coordinates Nervous system block.
Lectures for interdisciplinary week
Moderate student seminars.
POSTGRADUATE.
Advanced Masters in Neurology
For the first time in Malaysia, a well structured sub-specialty training programme
in Neurology is started at USM, in the academic year 2007-08. I am in charge of
conducting this course.
Masters programme.
Coordinator for Phase I Neurosurgery Masters programme
Organize the Phase I Neurosurgery teaching schedules, rotations, conduct internal assessment and Phase I examination.
Supervising training of masters students from Psychiatry, Ophthalmology, Emergency Medicine and Surgery rotating through Neurosciences Department.
Conduct clinical teaching and moderate seminars, tutorials, journal clubs for P.G. students.
Supervise thesis work
1 Dr Masnun Mahmood M Med Radiology. “Correlation of CT perfusion parameters with Stroke severity in acute Ischaemic Stroke patients”- Co supervisor- completed May 2005
2 Dr Abdul Rahman Izaini Ghani. M Med Neurosurgery. “Survival probability and functional outcome at 6 months in surgical treatment of Spontaneous Supratentorial Intracerebral Haemorrhage”- Co investigator. Completed in 2006.
3 .Dr Zulkifli Zaki Abdul Ghani. M Med Radiology. “ Preliminary study of CT perfusion of Penumbra in patients with Hypertensive Intracranial Haemorrhage”. Co Investigator.Completed May 2005.
4. Dr Sani Sanuti. M Med Neurosurgery. “Surgery for refractory epilepsy A pilot study”. Main supervisor. Completed in 2006
6. Dr Siti Suhaila Bt Ismail. M Med Radiology. “ Hippocampal Volumetric studies in patients with refractory Epilepsy”. Co investigator. Completing in May 2006
7. Dr Chan. M.Med Neurosurgery. Study of Post traumatic seizures- predictors of seizure development and role of prophylactic antiepileptic drugs. Completing in 2008.
Evaluate thesis-
1. Master’s Thesis- 2002-03. “MRI in Epilepsy. Correlation study with EEG”. USM
2. Master’s Thesis- 2003-2004.” A Pilot study-Prevalence of negative plain CT Scan and positive CT perfusion study in cases of acute stroke.” USM
3 Masters thesis- 2005.CT Brain study to determine the site of predilection of intracranial lesions in HIV/AIDS patients and its association with neurological symptoms and CD4 count.
4. Masters thesis- 2007.Comparison between FLAIR and Complete sequence MRI brain in patients with headache and no neurological deficits.
Supervisor of MSc students. Mohd.Harizal working on “Effects of treatment with Mitragina speciosa korth extract on psychoactivity of rat hippocampus: in vitro and in vivo study”. Supported by USM short term grant held by me.
Mazira working on “APOE-e in Haemorrhagic stroke” and the study is in progress.
RESEARCH- CONFERENCES-PUBLICATIONS
RESEARCH TRAINING
Short Course on Practical Statistics for Medical Research
Attended this training programme on Research Methodologies and Statistical Applications in Medicine, conducted by the Royal Post-Graduate Medical School, London. 18-22.January 1988.
Short course on “ Good Clinical Practice”. October 6-8. 2002
Attended this 3-day course on GCP guidelines for conducting clinical trials and clinical research, organized by University Sains Malaysia, in October 2002.
Ethics in Medical and Health research. 28-29.July 2004. Two-day workshop organised by U.S.M. and conducted by Dr Emma Williamson, Univ: Bristol, U.K.
Research work undertaken./ ongoing
1. Immune mediated Polyneuropathies.
Most of my early research work was centred on Guillain Barre Syndrome and Chronic Inflammatory Demyelinating Polyneuropathies. It involved prospective study of the natural history, outcome prediction, role of Plasmapheresis, Clinicopathological and Immunological studies and cost effective studies. Most of these works are published.
2. Myasthenia gravis. Large experience with MG and Thymectomy. Results of Thymectomy in Asian population and the Experiences in Oman are already published.
3. Multiple Sclerosis. Clinical epidemiological studies in MS patients.
4. Stroke Studies on the Clinical radiological correlations in acute stroke, Role of Mitral Valve Prolapse Syndrome in Young stroke
Original description of “MUCOID VASCULOPATHY” a new entity of non
atherosclerotic disease of blood vessels causing stroke.
Correlation of CT perfusion parameters with severity in acute ischemic stroke patients. Survival probability and functional outcome at 6 months in surgically treated spontaneous intracerebral haemorrhage. Preliminary study of CT perfusion of Penumbra in patients with Hypertensive intracranial haemorrhage. APOE in Haemorrhagic Stroke.
5 Epilepsy
Surgery for Epilepsy- A pilot study
Refractory seizures- Clinical-Radiological and Neuropsychological evaluation
CLINICAL TRIALS UNDERTAKEN
1. Valproate in Partial Epilepsy. Principal investigator of this multinational clinical trial at University Sains Malaysia. The trial worth US$ 6,000 was successfully completed in
July 2004. Results are pending analysis
2. PROFESS- Principal investigator at USM for this multinational clinical trial evaluating secondary stroke prevention. This trial brings in revenue of US$ 220,000.00 to the University. Trial will be completed in March 2008
3. PERFORM- Principal investigator for this International Multicentric clinical trial. Evaluating secondary stroke Prophylaxis. Revenue of Euro.120,000.to the University. Trial is expected to be completed in 2010.
4. ENOS. Principal investigator for this investigator initiated multicentric study evaluating the role of B.P. management in acute stroke.
CONFERENCE PRESENTATIONS
1 J.Tharakan. National Seminar on "Infections of Nervous System", New Delhi 1981.
2 J.Tharakan. National Seminar on "Recent Advances in Neurosciences”, Trivandrum 1983. Read a paper on "Etiological Concepts in M.N.D".
3 J.Tharakan Annual Conference of Neurological Society of India, Madurai 1983. Read a paper on "Plasmapheresis in Acute Polyneuritis".
4 J.Tharakan. Annual Conference of Neurological Society of India. Patna 1985. Read a paper on "Immunohistological Studies in Acute Inflammatory Polyneuropathy".
5 J.Tharakan. W.H.O. sponsored workshop on "National Curriculum for Neurosciences", Bangalore 1986.
6 J.Tharakan. Annual Conference of Neurological Society of India, Delhi 1986. Read a paper on "Painful Ophthalmoplegia - Sinister Variety".
7 J.Tharakan. Conference of the "Association of British Neurologists", London 1987.
8 J.Tharakan. Gave a short research seminar on "Inflammatory Polyneuropathies" at the Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, U.S.A. (June 1988).
9 J.Tharakan. XIVth World Congress of Neurology, New Delhi, 1989. Read a paper on "ClinicoPathological Study of Seven Patients with Guillain Barre Syndrome"
10 J.Tharakan. Workshop on "Neuroimmunology" conducted by the National Institute of Immunology New Delhi, February 1990. Gave a lecture on "Immunology of Acute Inflammatory Polyneuropathy"
11 J.Tharakan. Annual Conference of Neurological Society of India, Indore 1990. Read a paper on "Prognostic Factors in GBS Prospective Study of 100 Patients".
12 J.Tharakan. IXth Asian Ocean Congress of Neurology Tokyo, September 1991. Read a paper on "Mucoid Vasculopathy - A New Entity of Non-atherosclerotic stroke in the young - A Preliminary Clinico-Pathological Study".
13 J.Tharakan. International Update Session on Neurosciences, Muscat, December 1991. Gave a lecture on “Plasmapheresis in Neurology".
14 J.Tharakan. Annual Conference of Neurological Society of India: 1993 - Symposium on Guillain Barre Syndrome - Gave an invited lecture on "Recent advances in the management of G.B.S."
15 J.Tharakan. XVI World Congress of Neurology, September 1997. Buenos Aires, Argentina. Presented a paper on Multiple Sclerosis in Oman: A clinicoepidemiological study
16 J.Tharakan. Neurology Update Seminar- 1997. Ministry of Health Muscat. Invited lecture on “Treatment of refractory Epilepsy”
17 J.Tharakan. Recent advances in Rheumatology. January 1999. Sultan Qaboos University. Muscat.
18 J.Tharakan. 51st Annual Conference of American Academy of Neurology. April 1999, Toronto. Canada
19. J.Tharakan. The 8th Pan Arab Neurological Sciences Conference and 2nd Pan Arab Epilepsy Conference. April. 2000, Beirut.
20 J.Tharakan. Second GCC conference of Neurology, November.2001 Muscat. Read a paper on “Multiple Sclerosis in Oman”
21 J.Tharakan. Neurology for the General Practitioners- July 2002. University Sains Malaysia. Organized this 2-day conference. Gave 2 lectures on Stroke Current concepts of management and Treatment of Refractory epilepsy
22. J.Tharakan. National Postgraduate Neurology Update Seminar, July 16-19.2002. University Kebagsan Malaysia. Kuala Lumpur. Gave 2 lectures- “GBS-What is new?” And “Recent Advances in Disorders of Neuromuscular Junction”
23 J.Tharakan. Neurology Update-2003. February-15-16.Organized this national level Post Graduate course at University Sains Malaysia and gave two lectures- “Diagnostic approach to Peripheral Neuropathy” and “Mitochondrial Myopathy”. Also conducted the clinical interactive sessions during this course.
24 J.Tharakan. Malaysian Society of Neurosciences. - Annual conference April 4-5.2003. Member of the expert panel on “Neuromuscular disorders –Clinico Pathological course.”
25 J.Tharakan. Paediatric Genetics Seminar. April 9.2003. University Sains Malaysia. Kota Bharu.
26 J.Tharakan. Neuropsychiatry workshop. 30th May- 1st June 2003.
Langkwai Malaysia
27 J.Tharakan. Parkinson’s Disease an Update. 14th July 2003. University Sains Malaysia.
28 J.Tharakan. FORUMS-on MS- “Improving the management of MS in Asia” 16th August 2003 Perth. Australia.
29 J.Tharakan. ASEAN Neurological Associations conference-ASNA. Nov29-Dec2. 2003. Cebu- Philippines.
30 J.Tharakan. Asia Pacific Regional meeting of International Working Group on “Harmonisation of dementia drug guidelines”. 23rd - 26th March.2004. Bangkok. Thailand.
31 J.Tharakan. Symposium on Epilepsy in the Women –20-21st March 2004. Singapore. Conducted by Prof Martha J Morrell USA.
32 J.Tharakan. Multiple Sclerosis Symposium2004. Changing Malaysia’s Paradigm. 23rd May 2004 Kuala Lumpur. Malaysia.
33. J.Tharakan Workshop on “ Ethics in Medical Research”University Sains Malaysia. 28- 29th July 2004.
34. J.Tharakan. 5th Asian Oceanian Epilepsy Congress- Bangkok. 28-31
August 2004
35. J.Tharakan. National conference on “Neurocritical care” – University Sains Malaysia. 4-5 September 2004. Gave 2 lectures- “Approach to unconscious patient” and “Acute flaccid Paralysis”
36. Attended the Annual conference of American Academy of Neurology -28th April-5th May 007.BostonUSA.
37. Neurology update-1 . AAN full day course. 30-April 2007
38. Neurology Update-2. AAN full day course. -4-Mayl 2007
39. Deep Brain Stimulation for Parkinson Disease” AAN half day course-5 may 2007
40. Chaired the session on “Parkinsons Disease-new treatment options” organized by the Neurosciences Department June 2007.
41. Chaired the session “Update on treatment of Parkinson’s Disease” organized by MMA-Kelantan. 19-07-2007.
42. Chaired the session on “Epilepsy Recent advances “ organized by the Neurosciences Department August 2007.
43. Ist Asian and Oceanian Parkinsons Disease and Movement disorders Congress. Singapore. 20-22 October 2007.
44. Invited to chair the scientific session at the Annual conference of Neurological Society of India . Agra 14-17 December 2007
RESEARCH EXPERIENCE- PUBLICATIONS
PUBLICATIONS
1. Tharakan, JKJ(80%). Bhatia R.: Continuous Hemifacial Spasm in Cerebello Pontine angle Tumors. Neurol.India 1981. 29 (3): 112-115
2. Tharakan, JKJ.(80%) Ahuja, G.K.; Manchanda, S.C.; Asha Khanna: Mitral Valve Prolapse and Cerebrovascular Accident in the Young. Acta. Neurol. Scandinav. 1982. 66: 295-302.
3. Tharakan, JKJ.(80%) Tandon M.; Maheswary, M.C.; Plasmapheresis in Acute Inflammatory Polyneuropathy. A Case Report. J. Assoc. Physicians, India 1982. 30(3): 155-156.
4. Ahuja, G.K.; Tharakan, JKJ(80%). Ipsilateral Seizures. Epilepsia 1982. 23 (5):. 555-561
5. Tharakan, JKJ.(70%); Mohanta A.; Maheswary M.C.; Goulati R.K.: Clinical and CT Correlation in Cases of Cerebro Vascular Accident. Neurol. India 1984. 32 (4): 21-26.
6. Tharakan,(60%) JKJ; R.E. Ferner; R.A.C. Hughes; J. Winer; M. Barnett; E.R. Brown; G. Smith: Plasma Exchange for Guillain Barre Syndrome. J. Royal Society of Medicine. 1989. 82: 458-461.
7. Mohan. P.K.; J. Shanmugan; Ashalatha Nair; Tharakan, JKJ(50%). Fatal Outcome of Group G. Streptococcal Meningitis. A Case Report. J. Postgraduate Med. 1989. 35 (1): 49-50
8 Sandhyamoni S, Radhakrishnan VV, Tharakan, JKJ,(50%) Nair MD. Nonatherosclerotic cerebral vascular disease. A histopathological report on 2 cases. D. Rout. Proceedings of International Symposium on vascular lesions of the brain, 1989; 95.
9. Tharakan, JKJ.(70%); Jayaprakash P.A.; Padmanabhaiyer V.: Small Volume Plasma Exchange in Guillain Barre Syndrome. Experience in 25 patients. J. Assoc. Physicians, India. 1990. 38 (8): 550-553.
10. Honaver M., Tharakan, JKJ;(70%) R.A.C. Hughes; S. Leibowitz; J.B. Winer: Clinico- Pathological Study of Guillain Barre Syndrome. Nine Cases and Literature Review. Brain 1991. 114: 1245-1269.
11. Tharakan, JKJ,(60%) Sandhyamoni S, Nair MD, Radhakrishnan VV. Mucoid vasculopathy - A new entity of non-atherosclerotic stroke in the young. A preliminary clinicopathological study. Abstracts - 8th Asian Ocean Congress of Neurology 1991; 119.
12. Tharakan, JKJ,(70%) J. Mathai, A. Mathai, P.V.Sulochana: Immune complex levels and Plasmapheresis in Guillain - Barre Syndrome. Acta. Neurol 1993. 15:138-141
13. Pratap Chand R, Tharakan JKJ(50%), Dilip Kumar S: Juvenile onset O.P.C.A. Canadian J. Neurol Sci: 1993. 20 ( Suppl 4) 120
14. C. Sarada, Tharakan.JKJ(70%), M. Nair: Guillain Barre Syndrome. A prospective clinical study in 25 children and comparison with adults. Ann. Trop. Paed: 1994, 14. 281 - 286.
15. Pratap Chand R, Guru Raj AK, Tharakan.JKJ(40%), Dilip Kumar S: Enlargement of foramen of Magendie in childhood O.P.C.A. Neurol INDIA 1995; 43:124-125
16. Jacob PC, Tharakan JKJ(50%). Hypomelanosis of Ito - A rare neurocutaneous syndrome. Neurol India 1995; 43:177-178
17. Tharakan JKJ, (70%)Jacob PC. Lesson learned. Elevated ESR in an elderly stroke patient. J. Family Practice 1995; 41(5): 512-513.
18. Jacob PC, Pratap Chand R, Tharakan JKJ,(40%) Koul RL. Clinical profile of Dystonic syndromes in an Oman University Hospital. Saudi Med. J 1996; 17(4): 461-465.
19. Pratap Chand R, Tharakan JKJ(40%) , Koul RL, Dilip Kumar S. Clinical and Radiological features of juvenile onset olivopontocerebellar atrophy. Clinical Neurol Neurosurg 1996; 98: 152-156.
20. Narayan SK, Sarada C, Radhakrishnan K, Nair MD, Kartha CC, Neelakandhan KS, Tharakan JKJ.(60%) Response to thymectomy in South Indian patients with myasthenia gravis. Acta Neurol Scand 1996; 94:63-66
21. Scrimgeour EM, Koul RL, Chand RP, Tharakan JKJ.(30%) Juvenile onset Huntington’s Disease in an Omani child with asymptomatic, at risk parents. J. Med. Genet 1997; 34:701.
22 Tharakan JKJ,(60%) Chand P, Jacob PC. Multiple Sclerosis in Oman: Clinical and epidemiological study. J. Neurol. Sciences. 1997; 150 (suppl): 188.
23 Jacob.PC, Chand.P, Tharakan.JKJ(40%) Cerebral cortical lesions leading to dystonia. Neurosciences. 1998; 3:208-210.
24 Bulusu.S, Chand.RP, Jacob.PC, Tharakan.JKJ.(40%) The Sympathetic Skin Response in Carpal Tunnel Syndrome. Autonomic Neuroscience;Basic and Clinical.2000; 84: 119-121.
25 Jacob.PC, Chand.RP, Bulusu.S, Tharakan.JKJ.(40%) Clinical profile of Carpal Tunnel Syndrome in Oman. Neurosciences. 2000; 5(4): 223-225.
26 Jacob.PC, Tharakan.JKJ(70%), Chand.RP, Koul.RL, Alexander.PC Clinical profile of Myasthenia Gravis in the Sultanate of Oman. Neurosciences.2003;8(3) 171-172.
27. Rao. TV, Tharakan.JKJ(60%), Jacob. PC. Systemic lupus erythematosus presenting as amyotrophic lateral sclerosis. Clinical neuropathology. 2004; 23:99-101
28 Zamzuri Idris, J.Abdullah, J.P. George, J.Tharakan KJ(20%), A.Prasad, S.Sayuthi, A.Rahman Izaini Ghani, M.Saufi Awang, M.Rusli Abdullah, A.Rahman Mohd. Ariff,
G.Ghazali, M.Mohamad Ghazali and I.Roberts. 2002. The MRC CRASH Trial Pilot Phase in Malaysia, International Conference on Recent Advances in Neurotraumatology, Bali (Indonesia), pg 143-147.
29. A.R.I. Ghani, J.M. Abdullah, P.J.George, A.M. Hussin, K.J.J.Tharakan(10%), A.Prasad. 2004. A Simple Intraoperative Chart for Stereotactic Surgery for Movement Disorders in Developing Nation. Acta Neurochirurgica. Vol 146. pg 925.
30. K.Man, M.M. Abdul Kareem, N.A. Ahmad Alias, I.L.Shuaib, J.Tharakan,(20%) A.Prasad, A.M. Hussin, J.M. Abdullah. 2004. Outcome and cost effectiveness of urgent perfusion CT scan services in a rural based Malaysia University Hospital for stroke patients. 5th World Stroke Congress, Vancouver B.C., Canada. pg 142.
31. J Abdullah, Y Mohamed, NN Alias, IL Shuaib, J Tharakan.(20%) 2004. Cross sectional study of aetiology, clinical and electroencephalographic correlation of rural North East Malaysian patients with intractable epilepsy : Is there a high incidence of traumatic head injury causing epilepsy? 7th International Neurotrauma Symposium. Adelaide .2004. pg 129
32. T Ahamed, J.Abdullah, F Zakaria, F.Mustapha, J.Tharakan(10%), AMH Zabidi-Hussin. Nonlinear Dynamic Modeling of Epilepsy sufferers after Head Injury. 7th International Neurotrauma Symposium. Adelaide 2004. pg 61-64.
33. Jafri Malin Abdullah, Ahmad Munnawir Hussin, John Tharakan, Mohamed Rusli Abdullah, Ramli Saad, Zaidun Kamari, Zabidi Azhar Mohd Hussin and Dzulkifli Abdul Razak..National response to neurological diseases in Malaysia:planning for the future. The Southeast Asian J.of Tropical Medicine and Public Health. July 2006;Vol 37: (4).
34. Man K, Kareem AM, Ahmad Alias NA, Shuaib IL, Tharakan J, Abdullah JM, Prasad A, Hussin AM, Naing NN. Computed tomography perfusion study of ischaemic stroke patients in a rural Malaysian tertiary referral centre. Singapore Med J. 2006 Mar;47(3):194-7.
35. Mohamad Ghazali Mazira, Tharakan John, Abdullah Jafri Malin, Ghani Abdul RahmanIzaini, Abdul Rashid Faridah, Abdullah Mohamed Rusli. Preminilary study on apolipoprotein E epsilon 4 in hemorrhagic stroke.Presented at the 3rd Singapore International Neuroscience Conference, 23-24 May 2006 : 28.
36. J.M.Abdullah, Z.Z Abdul Ghani, N.A. Ahmad Alias, S.Jalaluddin, J.Tharakan, N.N.Naing, A.R.I Ghani. Computer tomography perfusion of penumbra versus outcome in hypertensive intracranial haemorrhage undergoing conservative versus surgical management: a prospective study. Journal of Neurology; Vol.253 :II/65.
37. J.M.Abdullah, J.Tharakan, A.R.I Ghani, Z.Idris, S.Sayuthi, S.Awang, N.Abdul Wahab,M.Mohamad Ghazali, N.Murshid, F.Abdul Rashid. Survival analysis and functional outcome at 6 months in surgical treatment of spontaneous supratentorial intracerebral haemorrhage. Journal of Neurology; Vol.253 :II/65.
38. Jafri Malin Abdullah, Ahmad Munnawir Hussin, John Tharakan, Mohamed Rusli Abdullah, Ramli Saad, Zaidun Kamari, Zabidi Azhar Mohd Hussin and Dzulkifli Abdul Razak. National response to neurological diseases in Malaysia : planning for the future. The Southeast Asian Journal of Tropical Medicine and Public Health. July 2006;Vol 37: (4).
39. Man K, Kareem AM, Ahmad Alias NA, Shuaib IL, Tharakan J , Abdullah JM, PrasadA,Hussin AM, Naing NN. Computed tomography perfusion, study of ischaemic stroke patients in a rural Malaysian tertiary referral centre. Singapore Med J. 2006 Mar;47(3):194-7.
40. Y.Mohammed, NN Alias, IL Shuaib, J.Tharakan. , J Abdullah, AH Munawir and NN Naig. Referral of epileptic patients in north east coast of west – an area with poor MRI coverage. An analysis.. Southeast Asian j Trop. Med. Pub. Health.2006; 37(6): 1199-1208.
41. Hussin A.M, A.Prasad, J.Tharakan(60%), J.Malin, Abdul Rahman. 2003. Recombinant tissue plasminogen activator(rt-PA) in acute stroke – USM experience. MJMS. 2003;10: 124
42. Saufi A, Abdullah J, George Jain P, Tahir A, Abdullah MR, Tharakan J,(50%) Prasad A, Munawwir H, Salmi R. 2003. Nerve conduction study of the upper limb and lower limb in healthy subjects. A comparison between sexes. Preliminary results. MJMS. 2003;10:133-134.
43. S.Sayuthi, J.Abdullah, J.Tharakan,(10%) George Jain P, A.Prasad, Tahir A, S.S. Hassan, Z.Idris, ARI Ghani, S.Awang, K.Salleh, R.Yaacob, Z.Hussin. 2003. Smart balancing for vestibular rehabilitation. MJMS. 2003; 10:156-157.
44. Adnan T, Saufi A, Abdullah J, Idris Z, Ghani ARI, Sayuthi S, Wahab N, Ali D, Rasalingam K, Tharakan J(10%), Prasad A, Munawwir H, Salmi R. 2003. Magnetic stimulation of the central and peripheral nervous system – our experience in Neurosciences Unit. . MJMS. 2003; 10: pg 157.
45. Ghani ARI, Tharakan J(70%), Prasad A, Hussain AM, J.Abdullah,George Jain P. Spinal multiple sclerosis : a case report. . MJMS. 2003; 10:170.
46. Sayuthi, J.Abdullah, J.Tharakan(10%), J.George, A.Prasad, A.R.Ariff, NA Wahab, A.Rahman, S.Awang, Z.Idris. Case report of rare spontaneous caroticoca venous fistula (CCF) associated with two arteriovenous malformations (AVM). MJMS. 2003; 10:173-174.
47. ARI Ghani, J.Abdullah, J.George, P.R.Gollapudi, AM Hussin, J. Tharakan (10%)and A.Prasad. A simple intraoperative chart for stereotactic surgery for movement disorders in developing nation. MJMS. 2004; 9th National Conference on Medical Sciences. pg 160.
48. Idris Z, Ghani ARI, Sayuthi S, Awang MS, George J, Prakash RG, Tharakan J (60%)and Abdullah JM. 2004. Multiple sclerosis or intracranial tumour ?: A proper clinical evaluation, radiological images and steroids trial therapy could differentiate them. 9th National Conference on Medical Sciences. pg 163.
49. Saufi A, Abdullah J, John T(20%), Atul P, Munawwir H, George J, Sayuthi S, Tahir A, Abdullah MR and Salmi A.R. Nerve conduction study among healthy Kelantanese. The influence of age, sex, height and weight on nerve velocities. 9th National Conference on Medical Sciences. pg 178.
50 Shafie A, Zamzuri I, Jafri MA, Tharakan J, Abdul Rahman IG, Mohamed Saufi A, Sani S, Murshid N.A rare case of multiple intracerebral haemorrhage in a female with abnormal platelet aggregation test and right middle cerebral artery aneurysm. The Malaysian Journal of Medical Sciences, 2005; Vol 12,Suppl 1; 228.
51. Abdul Rahman IG, Murshid N, Jafri MA, Tharakan J. Neurochemical monitoring using intracerebral microdialysis in patients with spontaneous supratentorial intracerebral hemorrhage (ICH). The Malaysian Journal of Medical Sciences, 2005; Vol 12,Suppl 1; 230.
52 Sani S, Tharakan J, Jafri MA, George J, Salma W, Soccoro M, Madhavan M, Awang S, Abdul Rahman IG, Toh CJ, Tahir A.Pre-operative evaluation for refractory epilepsy: Universiti Sains Malaysia Programme. The Malaysian Journal of Medical Sciences, 2005; Vol 12,Suppl 1; 231.
53 Abdul Rahman IG, Jafri MA, John Tharakan, Zamzuri I, Sani S, Mohamed Saufi A, Naseer AW, Mazira MG, Nur-Leem Murshid, Faridah AR.Survival analysis and functional outcome at 6 months in surgical treatment of spontaneous supratentorial intracerebral hemorrhage (ICH). The Malaysian Journal of Medical Sciences, Volume 13 (Suppl 1) 2006; 152.
54. Maria SP, Rahida MS, John Tharakan, Jafri MA, Sani S. The impact of epilepsy surgery on the quality of life of patients: Preliminary results. The Malaysian Journal of Medical Sciences, Volume 13 (Suppl 1) 2006; 156.
55. Mazira MG, John T, Jafri MA, Abdul Rahman IG, Faridah AR, Mohamed Rusli A. Preminilary study on apolipoprotein E epsilon 4 in hemorrhagic stroke. The Malaysian Journal of Medical Sciences, Volume 13 (Suppl 1) 2006; 191.
56 Harizal SN, Mordi MN, Mansor SM, Hilman S, Khoo KH, Azim P, Nasir MN, Mohd Ghazali M, Rammes G, Hasnan J, Tharakan J KJ, Zulkifli M, Abdullah J. Detection of Mitragynine from mitragyna speciosa korth crude extract by using gas chromatography mass spectrometry (GC-MS) for learning and memory process : preliminary result. ). The Malaysian Journal of Medical Sciences, Volume 13 (Suppl 1) 2006; 193
