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AstraZeneca PLC 2012 Annual General Meeting 26 April 2012 Welcome to our Annual General Meeting

AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

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Page 1: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting 26 April 2012

Welcome to our Annual General Meeting

Page 2: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting

Page 3: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting Louis Schweitzer

Chairman

Page 4: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting Shriti Vadera

Non-Executive Director

Page 5: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting Rudy Markham

Non-Executive Director

Page 6: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting Michele Hooper

Non-Executive Director

Page 7: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting Simon Lowth

Chief Financial Officer

Page 8: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting David Brennan

Chief Executive Officer

Page 9: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting Bruce Burlington

Non-Executive Director

Page 10: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting Jean-Philippe Courtois

Non-Executive Director

Page 11: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting Nancy Rothwell

Non-Executive Director

Page 12: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting Marcus Wallenberg

Non-Executive Director

Page 13: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting John Varley

Non-Executive Director

Page 14: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

14

AstraZeneca PLC 2012 Annual General Meeting Louis Schweitzer

Chairman

Page 15: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting

Page 16: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting Geneviève Berger

Page 17: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting Graham Chipchase

Page 18: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting Leif Johansson

Page 19: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting

Page 20: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting David Brennan

Chief Executive Officer

Page 21: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

21

Our values

AstraZeneca is

Global

Integrated

Innovation-driven

Focused

Biopharma

Our vision

Page 22: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

22

Industry outlook

Growth Sector

• Increasing and ageing populations

• Expanding populations in new markets

• Significant unmet medical need

• Continued scientific and technological advance

Pressures on

returns

• Decline in R&D productivity

• Established market price pressure

• Patent expiries and genericisation

Page 23: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

23

Corporate strategic priorities

• Transform R&D

organisation

• Improve quantity and

quality of output

• More outward-looking

and collaborative

• Drive productivity

Our values

Manage for long-term shareholder value

Deliver the business Business shape People Pipeline

Making the

most meaningful difference to patient health through great medicines

• Growth of current

products

• Innovative channels to

meet customer needs

• Drive growth in emerging

markets

• Build stronger

relationships with payers

• Reshape and simplify

business

• Restructure to improve

competitiveness

• Invest to drive growth

• Manage change in the

right way

• Acquiring and retaining

talent

• Developing leaders

• Improving diversity

• Improving engagement

Page 24: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

24

Corporate strategic priorities

• Transform R&D organisation

• Improve quantity and quality of output

• More outward-looking and collaborative

• Drive productivity

Pipeline

Page 25: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

25

Corporate strategic priorities

• Growth of current products

• Innovative channels to meet customer

needs

• Drive growth in emerging markets

• Build stronger relationships with payers

Deliver the business

Page 26: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

26

Corporate strategic priorities

• Reshape and simplify business

• Restructure to improve competitiveness

• Invest to drive growth

• Manage change in the right way

Business shape

Page 27: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

27

Corporate strategic priorities

• Acquiring and retaining talent

• Developing leaders

• Improving diversity

• Improving engagement

People

Page 28: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

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Corporate strategic priorities

• Committed to acting responsibly and to the

sustainable development of our business

• Integrity and high ethical standards

• Global Policy on External Interactions

• Revised IFPMA Code of Conduct

Values

Page 29: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting

Page 30: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

30

Reported EPS $1.28 $2.08 -38% -39%

Headline results: 1Q 2012

2012 2011 Actual CER $m $m growth growth

Core Operating Profit 2,997 3,678 -19% -18%

Revenue 7,349 8,292 -11% -11%

Core EPS $1.81 $2.23 -19% -19%

Page 31: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

31

Symbicort 723 752 -3%

Key brand revenue summary: 1Q 2012 2012 2011 CER $m $m growth

Seroquel XR 384 339 +14%

Crestor 1,500 1,478 +2%

Arimidex 144 233 -39%

Nexium 953 1,161 -18%

Seroquel IR 754 1,006 -25%

Page 32: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

32

Western Europe 1,775 2,235 -19%

Regional revenue performance: 1Q 2012

2012 2011 CER $m $m growth

US 2,920 3,304 -12%

Total Revenue 7,349 8,292 -11%

Established Rest of World 1,238 1,321 -9%

Emerging Rest of World 1,416 1,432 +1%

Page 33: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

33

Reported EPS $1.28 $2.08 -38% -39%

Headline results: 1Q 2012

2012 2011 Actual CER $m $m growth growth

Core Operating Profit 2,997 3,678 -19% -18%

Revenue 7,349 8,292 -11% -11%

Core EPS $1.81 $2.23 -19% -19%

Page 34: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting

Page 35: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

Resolutions 1. To receive the Company’s Accounts and the

Reports of the Directors and Auditor for the

year ended 31 December 2011

2. To confirm dividends

3. To re-appoint KPMG Audit Plc, London as Auditor

4. To authorise the Directors to agree the

remuneration of the Auditor

5. To elect or re-elect the following as Directors:

a) Louis Schweitzer

b) David Brennan

c) Simon Lowth

d) Geneviève Berger

e) Bruce Burlington

f) Graham Chipchase

g) Jean-Philippe Courtois

h) Leif Johansson

i) Rudy Markham

j) Nancy Rothwell

k) Shriti Vadera

l) John Varley

m) Marcus Wallenberg

6. To approve the Directors’ Remuneration

Report for the year ended 31 December 2011

7. To authorise limited EU political donations

8. To authorise the Directors to allot shares

9. To approve the New SAYE Scheme

10. To authorise the Directors to disapply

pre-emption rights

11. To authorise the Company to purchase

its own shares

12. To reduce the notice period for general

meetings

Page 36: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting

Page 37: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

Resolutions 1. To receive the Company’s Accounts and the

Reports of the Directors and Auditor for the

year ended 31 December 2011

2. To confirm dividends

3. To re-appoint KPMG Audit Plc, London as Auditor

4. To authorise the Directors to agree the

remuneration of the Auditor

5. To elect or re-elect the following as Directors:

a) Louis Schweitzer

b) David Brennan

c) Simon Lowth

d) Geneviève Berger

e) Bruce Burlington

f) Graham Chipchase

g) Jean-Philippe Courtois

h) Leif Johansson

i) Rudy Markham

j) Nancy Rothwell

k) Shriti Vadera

l) John Varley

m) Marcus Wallenberg

6. To approve the Directors’ Remuneration

Report for the year ended 31 December 2011

7. To authorise limited EU political donations

8. To authorise the Directors to allot shares

9. To approve the New SAYE Scheme

10. To authorise the Directors to disapply

pre-emption rights

11. To authorise the Company to purchase

its own shares

12. To reduce the notice period for general

meetings

Page 38: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting

• Please place your completed Polling Card in one of the

boxes as you leave the meeting room

• We expect to announce the results of the poll later today

• The results of the poll will also be published in the

Investors section of our website, astrazeneca.com

Page 39: AstraZeneca PLC 2012 Annual General Meeting · 2018-09-14 · 2012 Annual General Meeting • Please place your completed Polling Card in one of the boxes as you leave the meeting

AstraZeneca PLC 2012 Annual General Meeting

Thank you for attending and have a safe journey home