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-12 -8 -4 0 4 8 12
% Difference in Hip BMD
Association of selected lifestyle factors with BMD
Adjusted mean BMD* N Hip Spine Whole Body
__________________________________________________________________
Current Yes 39 0.935 0.969 1.069smoker No 135 0.968 0.987 1.088
(p=0.12) (p=0.40) (p=0.30)
Wt-bearing 0-<55 62 0.947 0.965 1.069activity 55-<70 62 0.962 0.997 1.086
70+ 50 0.976 0.986 1.099 (p=0.39) (p=0.26) (p=0.26)
Dietary 0-<650 60 0.944 0.972 1.072Calcium 650-<1300 53 0.971 0.986 1.071(mg/day) 1300+ 52 0.970 0.992 1.109
(p=0.30) (p=0.58) (p=0.06)
Dietary 0-<45 44 0.953 0.960 1.087Protein 45-<90 90 0.951 0.976 1.078(gm/day) 90+ 31 0.999 1.035 1.095
(p=0.26) (p=0.15) (p=0.70)
Dietary 0-<180 59 0.958 0.962 1.066Magnesium 180-<360 83 0.952 0.976 1.072(mg/day) 360+ 23 0.999 1.058 1.169
(p=0.29) (p=0.04) (p=0.002)
Any caffeine Yes 104 0.952 0.981 1.080intake No 70 0.973 0.986 1.089
(p=0.20) (p=0.77) (p=0.58)
Caff. cola 0-1 123 0.969 0.985 1.095(drinks/day) 2+ 50 0.938 0.978 1.053
(p=0.12) (p=0.72) (p=0.01)
Alcohol 0 74 0.954 0.978 1.078(drinks/mo) <5 62 0.969 0.996 1.098
5+ 38 0.960 0.970 1.072 (p=0.71) (p=0.44) (p=0.31)
_________________________________________________________________________
* Adjusted for the following baseline covariates: age, height, weight, and calcium as continuous variables; ethnicity, number of periods in last year and hormone-based contraception as categorical variables.
mean ± s.e. median HIP BMD
Spearman correlation
Age at menarche (yrs.) 12.3 ± 0.1 12.0 0.05
Height (in) 64.1 ± 0.2 64.1 0.29*
Weight (lb) 142.4 ± 2.2 137.1 0.42*
Weight-bearing activity 61 ± 1 61 0.25*
Calcium (mg/day) 973 ± 47 833 0.11
Protein (gm/day) 66 ± 3 59 0.09
Magnesium (mg/day) 235 ± 9 220 0.09
Caffeine (mg/day) 52 ± 6 20 -0.10
Calories (kcal) 1717 ± 66 1593 -0.006
_______________________________________________________________________________
*p< 0.05
Study Setting Group Health Cooperative (GHC), a mixed-model HMO located in Washington state
Study Design Cross-sectional
Participants 174 adolescent women, ages 14-18 yearsSelected using computerized databases from this health plan
Inclusion/ Not pregnant or lactating, post-menarche, no Exclusion conditions or medications that might affect bone
density, informed consent from parents for participants <18
Data Collection Health questionnaire; Food frequency questionnaire; Exam; DEXA
Lifestyle Factors Current smoking; weight-bearing physical activity; dietary intake of magnesium, calcium, protein, alcohol, caffeine and caffeinated cola beverages
Outcome Hip, spine, and whole body bone mineral density (g/cm2) using DEXA
Analyses Association of lifestyle factors with BMD, after adjustment for the effects of age, height, weight, ethnicity, number of periods in the past year,
hormonal contraception, and dietary calcium
All study procedures were reviewed and approved by the GHC Human Subjects Committee
Lifestyle Factors Associated with Bone Mineral Density in Adolescent WomenDelia Scholes1,2, Andrea Z. LaCroix1,2 , Laura E. Ichikawa1, Susan M. Ott2, William E. Barlow1,2
1Group Health Cooperative and the 2University of Washington, Seattle WA
INTRODUCTION
Background
Maximizing peak bone mass is essential for prevention of future morbidity from osteoporosis.
Adolescence is a particularly critical time for bone mass accrual. More than half of peak bone mass is attained during adolescence and, for many anatomic sites, bone mass accrual is virtually complete by age 18.
Heritable factors are most important in peak bone mass attainment. But identification of modifiable risk factors offers opportunities for interventions aimed at improving bone health.
A number of lifestyle factors, including dietary factors, smoking, and exercise, have been both positively and negatively associated with bone density.
Purpose
To evaluate the association between selected lifestyle factors and bone mineral density in a population-based study group of adolescent women.
METHODS
RESULTS
Summary of Results
A number of biologic and lifestyle variables were associated with bone density as the hip or other anatomic site.
However, after adjusting for other factors known to affect bone density, the majority of the lifestyle factors we examined were not significantly associated with BMD in these adolescents.
Two dietary factors, magnesium and caffeinated cola consumption, were significantly associated with BMD in this study group:
• Dietary intake of magnesium was positively associated with BMD at two anatomic sites, the spine and whole body.
• Consumption of caffeinated cola beverages was negatively associated with whole body BMD.
CONCLUSIONS
When compared to inherited and hormonal influences, lifestyle factors may have relatively modest effects on bone density and bone mass accrual in essentially healthy adolescent women.
Studies of these factors to date have had inconsistent methods and findings.
Future prospective studies or randomized trials of sufficient size are needed to determine whether these factors in adolescents can be modified to improve bone health.
This research supported by The National Institutes of Health (NICHD, R01HD31165)
Selected Baseline Characteristics
Total hip BMD, g/cm2 0.956 ± 0.009
Spine BMD, g/cm2 0.982 ± 0.009
Whole body BMD, g/cm2 1.082 ± 0.008
Magnesium 180-<360 mg/day (vs. <180)
Calcium 1300+ mg/day (vs. <650)
Calcium 650- <1300 mg/day (vs. <650)
Wt. Bearing activity score 70+ (vs. <55)
Wt. bearing activity score 55-<70 (vs. <55)
Age 16-18 (vs. 14-15)
Non-white
BMI <18.5 (vs. normal)
BMI 25-<30 (vs. normal)
BMI 30+ (vs. normal)
0-7 periods (vs. 8+)
Ever pregnant
Hormonal contraception
Magnesium 360+ mg/day (vs. <180)
Smoker
<5 alcoholic drinks/mo (vs. 0)
5+ alcoholic drinks/mo (vs. 0)
2+ caff. cola drinks/day (vs. 0-1)
Personal fracture
Correlation between selected variables
Wt. bearing Calcium Protein Magnesium Caff. Cola Alcohol activity
_______________________________________________________________________________
Wt bearingactivity 0.24* 0.27* 0.28* -0.23* -0.09
Calcium 0.87* 0.87* -0.14 0.02
Protein 0.88* -0.11 -0.002
Magnesium -0.20* 0.005
Caff. Cola 0.18*_______________________________________________________________________________
Age -0.09 -0.05 -0.01 0.03 0.11 0.22*
BMI -0.05 -0.07 -0.09 -0.09 0.14 0.07_______________________________________________________________________________
*p< 0.05