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Introduction to Association Mapping Module
Association Mapping: GWAS and Sequencing Data
Instructors: Timothy Thornton and Michael Wu
Summer Institute in Statistical Genetics (SISG)
July 2019
Seattle, Washington
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Introduction to Association Mapping Module
Introduction: Course Aims
This is a course on statistical methods and software for geneticassociation studies of complex traits. We aim to cover:
I Case-Control Association Testing
I Genetic Association Testing with Quantitative Traits
I Gene and Pathway Level Analysis
I Population Structure/Ancestry Inference
I Genetic Association Testing in Samples with Structure
I Interaction Analysis
I Collapsing Tests for Rare Variant Analysis
I Kernel Tests and Omnibus Tests for Rare Variants
I Power and Sample Size, Design Considerations, EmergingIssues
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Introduction to Association Mapping Module
Introduction: Resources
Importantly, the class site is:http://faculty.washington.edu/tathornt/SISG2019.html
Contains (or will contain);
I PDF copies of slides (in color)
I Datasets needed for exercises
I Exercises for you to try
I Our solutions to exercises (later!)
I Links to software packages
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Introduction to Association Mapping Module
Introduction: About Mike
I Associate Member,FHCRC Public Health Sciences Division
I Affiliate Associate Professor,UW Boistatistics
I Research in:High dimensional dataKernel machine methodsVariable selection and regularizationPathway and network based analysisTranslational researchStatistical genomics/genetics
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Introduction to Association Mapping Module
Introduction: About Tim
I Associate Professor,UW Biostatistics
I Affiliate Investigator,Fred HutchinsonCancer Research Center
I Research in:Genetic Association StudiesCorrelated Genetic DataInferring Genetic AncestryRelatedness EstimationPharmacogenomics
... and you?
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Introduction to Association Mapping Module
Introduction: Course Structure
I 10 sessions over 2.5 daysI What to expect in a typical session;
I 45 mins teaching/lectureI 30 mins hands-on exercisesI 15 mins summary, discussion
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