AspireLIFE Efficacy Report aug 2012 - Shopify · caused by oxidative stress and urban pollution. ! Efficacy Report - 2010! ... Merospheres is liposomal Ursolic Acid (URA) that stimulates

AspireLIFE

Active Ingredients Efficacy Report

Efficacy Report - 2010

2 of 29

Photosomes

DESCRIPTION

Photosomes is photolyase in multilamellar liposomes, derived from photosynthetic plankton called Anacystis nidulans. The liposomes (200 nanometers in size) are formed from pure egg phospholipids.

PROPERTIES

Comparable to chlorophylle, which also requires light activity, the mode of activation of Photolyase absorbs visible light to directly cleave and reverse damage caused by shorter wavelength UV. Twelve human volunteers who have applied Photosomes to UV-exposed skin had about a 52% reduction in UV damage. Photosomes protects the cells of the skin's immune system. In vitro tests demonstrate that Photosomes reduces the secretion of Interleukine -6 ( IL-6). Normal skin keratinocytes respond to the master immunity molecule interferon by displaying an important adhesion molecule (ICAM-1) on their surface. This adhesion molecule is necessary for proper communication with leukocytes. In UV exposed skin, ICAM-1 is not displayed; keratinocytes don't respond to inter-feron. After treatment with Photosomes, keratinocytes react appropriately and produce ICAM-1. In vivo tests were per-formed to demonstrate the reduction of "stress signals" by Photosomes. All these tests confirm the immuno-protecting capacity of Photosomes.


3 of 29

Photosomes

PHOTOSOMES REDUCES STRESS SIGNALS

Photosomes Prevent W-B erythema and restore immune response

UV erythema and suppression of immune response

Nickel Sulfate wheal and flare immune response

Light-activated Photosomes reduces cell damage (dimers or CPD's) and the release of IL-6.

1. UV 1. UV + Photosomes 1. UV + Photosomes + Light

IL-6 IFN-Gamma ICAM-1

Photosomes was used at 1%. Pictures were taken 24 hours after UV-B exposure.

PHOTOSOMES REDUCES CYTOKINE RELEASE


4 of 29

Undaria Pinnatifida

PRESENTATION

KIMARINE® is a patented fraction of low molecular weight extracted selectively from the brown seaweed Undaria pinnatifida (Harvey) Suringar collected in the Bassin of Thau (connected to the Mediterranean).

Undaria pinnatifida is known as "wakame" in Japan.

KIMARINE® contains a well-balanced composition in amino-acids and minerals. Alanine, glycine, glutamic acid and aspartic acid are present in abundance. The major minerals are K, Mn, Ca, Zn and Mn.

COSMETIC BENEFITS

Skin Care

KIMARINE® reinforces the natural defense system against everyday damage caused by reactive oxygen species as well as by over polluted environments, characterized by high amounts of exhaust fumes, cigarette smoke or else heavy metals such as lead and cadmium. In addition, KIMARINE® is a truly efficacious skin lightener. It can help removing hyper-pigmentation and reducing the intensity or brown spots.

Hair Care

KIMARINE® has proved its powerful activity against UV irradiation and urban pollution. It allows to re-establish or to strongly reinforce scales cohesion due to its protecting-repairing properties.

Thanks to 1. its specific composition characterized by excellent bioavailability and to 2. its strong protecting activity from oxygenated reactive molecules of any nature and origin (e.g. UV

irradiation, urban pollution).

KIMARINE® is an interesting active ingredient for numerous kinds of cosmetic and toiletries products.

Skin and hair are every day submitted to different kinds of oxidative aggressions such as UV irradiation and urban pollutants.

At the skin level, these aggressions may induce great damage e.g. premature aging and dull skin complexion, with cumulative effects when associated. At the hair level, they may alter sensorial and mechanical properties.

To day, thanks to KIMARINE®, skin and hair may be protected efficaciously against damage caused by oxidative stress and urban pollution.


5 of 29

K-2% K-4% S T

In the following in vitro tests, cultured cells are placed in contact with increasing quantities of various pollutants and in the presence or the absence of the active.

The protective activity (in %) is evaluated for 2%n (green bar) and 4%n (yellow bar) of KIMARINE®.

In the in vitro test, on the right, free radicals are generated by the hypoxanthine-xanthine oxidase system. KIMARINE® is introduced according to 3 ways: 1. P1: 24 h before aggression

(absent during aggression) 1. P2: during aggression 1. P3: before & during

aggression.

KIMARINE® (K-2% or K-4%) shows a better protective activity of fibroblasts against UVA irradiation (dose: 24/J/cm2) compared to silymarin (S-dose: 5.10-4M) and a tocopherol (T-dose: 5.10-4M).

This in vitro assays confirm KIMARINE® ‘s functionality as a free radical scavenger.

This graph demonstrates that KIMARINE® can penetrate keratinocytes to protect them against intracellular free radicals IN). It also can intercept free radicals and act against immediate toxicity (P2). P3 = P1 +P2.

At 2%, KIMARINE® has high capacity of protection against pollutants:

1. +172% against lead chloride at 1mM

1. +148% against cadmium sulphate at 0.2mM

1. +86% against bisulfite activity at 10mM

Lead Cadmium

Exhaust Fumes Cigarette Smoke

0.25mM 0.5mM 1mM

Lead Chlorine Concentration

0.05mM

0.2mM 0.1mM

Cadmium Sulfate Concentrations

5mM 10mM

Sodium Bisulfite Concentrations 1% 4% 2%

DMSO – Cigarette Smoke

2.5 5 10 % KIMARINE


6 of 29

⇒LIGHTENING ACTIVITY In tyrosinase activity determinations, KIMARINE® inhibits more than 90 % enzyme activity with 2%.

The images illustrate the effect of KIMARINE® on skin biopsies histologically colored with L-dopa. KIMARINE® reduces pigmentation and acts as an effective skin lightener.

Dopa Control KIMARINE® 5%

In these ex vivo studies, dyed hair is submitted to UVA and over polluted environmental stresses. An aqueous solution with 2% KIMARINE® is sprayed either before or after stress. Hair is prepared for scanning electron microscope observations 24h after each experiment.

Normal hair exhibits smooth and uniform cuticle scales (control).

Dyed Hair Control no stress – no treatment

A: Protection against UVA (unique dose: 30 J/cm2 equivalent to 3h of a sunny day)

A1 – UVA Stress A2 – UVA Stress + 2% KIMARINE (after UVA stress)

B: Protection against cigarette smoke (6h exposure)

B1 – Cigarette Smoke Stress B2 – Cigarette Stress + 2% KIMARINE (after smoke stress) stress)

The electron micrographs reveal that both kinds of stress: UVA, (A1) and cigarette smoke (131 j induce important alterations o( cuticle scales e.g. cracks and uplifted scales compared to unstressed control. It appears clearly evident that KIMARINE® induces a repairing effect when applied after both stresses (A2 B2). Its activity is also effective when sprayed before damage (protecting effect) (data available upon request).

Complementary study against exhaust fumes: similar potent protection of KIMARINE® before and after stress (results available upon request).

KIMARINE® delivers both protecting and repairing activities of hair damaged by free radicals and over polluted environments.


7 of 29

Specifications (on a control batch)

- Appearance : limpid liquid light yellow colored - Odor : typical - pH : 5.8 +/- 1 - Density : 1.014 +/- 0.010 - Dry Residue (%) : 2.1 +/- 0.3 - Solubility : Soluble in ethanol, propylene glycol, butylene glycol : insoluble in oil - Microbiology : bacteria : < 100 germs/ml : yeasts, moulds : < 10 germs/ml : pathogens : free

Composition

Ingredients Amounts (%) Brown Alga Undaria pinnatifida extract 54 +/- 5 Solvent Water 45 +/- 5 Preservatives As required Others (antioxidants …) None INCI names Water CAS n0 7732-18-5 EINECS n0: 231-791-2

Undaria pinnatifida extract CAS n0 223751-81-3

è ECCOCERT APPROVED

The, data presented in this document ore offered solely for your consideration and investigation. No guaranty is expressed or implied. No responsibility or liability for any consequences arising from the use of these data can be accepted', including possible infringement of any potent.


8 of 29

Merospheres

PROPERTIES

As skin ages, lipid production decreases and skin gets thin and dry. Merospheres has the unique ability to reprogram keratinocytes to produce, as in youthful skin, the intermediate triglycerides and glyco-ceramides, and the most important barrier function lipids such as ceramides and cholesterol esters (as shown in Tests 1 and 2).

Unlike other compounds that stimulate lipid metabolism, Merospheres does not "differentiate" or thin the skin (as demonstrated by the lack of Phospholipid Proliferation in Test 1).

The use of Ursolic acid is restricted because of its insoluble character and difficulty in formulation. Merospheres solves the problems of poor delivery into the skin and difficulties in formulating by encapsulating Ursolic Acid in the lipid membrane of a specially engineered liposome.

DESCRIPTION

Merospheres is liposomal Ursolic Acid (URA) that stimulates lipid production to improve the skin barrier and to moisturize the skin from the inside. Ursolic Acid is found in Rosemary and is well-known for its anti-inflammatory properties. AGI Dermatics has recently applied for patents using this unique application.


9 of 29

Merospheres

EFFECT OF MEROSPHERES AND CERAMIDES - 8-DAY TREATMENT IN CULTURED …

Erythema Reduction in 3hrs (in hours)

Barrier Strength

The information contained in this technical bulletin is, to the best of our knowledge, true and accurate. No warranty, expressed or implied is made or intended. The use should be based upon the customer's own investigations and appraisal. No recommendation should be construed as an inducement to use a material in infringement of patents or applicable government regulations

PROTOCOL 1. 11 volunteers (23-56 yrs old) 2. Test Articles:

1. 1% and 10% Merospheres in hydrogel 2. Placebo controlled, double-blinded 3. Application to forearm day and night for 11

days 4. Skin Barrier and Recovery on Day 12 5. Challenge skin with tape stripping 6. Number of Tape strips in barrier 7. Recovery from erythema in 3hrs

Normal human epidermal keratinocytes were treated with 1% empty liposomes, 0.05% Merospheres and 1% Merospheres. Lipids were extracted and assayed by high performance thin layer chromatography. Observations were made compared to untreated NHEK (control). Results are as follows:

Total Ceramides (Barrier Function)

% In

crea

se O

ver C

ontr

ol

Untreated

1% Empty Liposomes

1% Merospheres

0.05% Merospheres

Observation: Merospheres increases the ceramides and the barrier functions


10 of 29


11 of 29

BV-OSC

PROPERTIES

1. BV-OSC at 0.1% reduces melanin synthesis by 80%. 2. BV-OSC at 10% eliminates age spots in 16 weeks. 3. BV-OSC at 3% in vivo reduces Delta-L value by 15% vs. placebo (22 people), a way to measure whitening effect. 4. BV-OSC at 0.1% in vitro increases collagen by 50%. 5. BV-OSC tested at 10% in vivo to treat acne with 80% of patients (12 people) satisfied with results. 6. BV-OSC increases collagen synthesis at least twice as much as ascorbic acid. 7. BV-OSC inhibits MMP-2 and MMP-9 over 3 times better than ascorbic acid. 8. BV-OSC penetrates the skin 4 times better than Magnesium Ascorbyl Phosphate. 9. BV-OSC delivers pure Vitamin C 50 times better than ascorbic acid. 10. BV-OSC decreases 8-OHdG induced by UV-A. 11. BV-OSC decreases p53 expression induced by UV-B. 12. BV-OSC protects the cells against UV-13 better than other esters of Vitamin C. 13. BV-OSC works synergistically with Thiotaine as both penetrate the cells for anti-oxidant activity.


12 of 29

BV-OSC

COMPARISON OF ABILITY FOR COLLAGEN SYNTHESIS

Proline involved in collagen synthesis was labeled by BH and added to human dermal fibroblasts (NHDF) with various concentrations of BV-OSC flascorbic acid and cultivated for 24 hours. Then collagen fractions were obtained. The amount of 3H taken into the collagen fraction was measured by using a liquid scintillation counter and slot blotter. As shown below. BV-OSC significantly promoted collagen synthesis.

ELIMINATES AGE SPOTS.

BV-OSC at 10% concentration was applied to the skin of 10 people for a period of 16 weeks. Results (below) show that BV-OSC eliminated age spots.


13 of 29

Thiotaine

PROPERTIES

Due to the quaternary group, Thiotaine resembles carnitine and reacts similarly. It is a carrier of fatty acids. Thiotaine increases fatty acids in the mitochondria allowing a higher efficiency in oxygen metabolism, therefore increasing ATP (energy) levels in cells.

Thiotaine's anti-oxidant activities are derived from its Thione (C=S). Thiotaine scavenges superoxide anion and singlet oxygen better than Coenzyme Q10 and Idebenone. In vitro tests have demonstrated that Thiotaine also has strong copper chelating power; it potentially can inhibit tyrosinase activity.

There is a natural transporter of ergothioneine named OCTN-1. It is a transporter of ergothioneine across the membrane that has been readily identified this year in fibroblasts, keratinocytes and the nucleus. This means that ergothioneine is a desirable molecule for the skin and is not a sensitizer. Thiotaine is an ideal companion to BV-OSC which will deliver Vitamin C in the cell. Ergothioneine recycles Vitamin C like Vitamin E would do.


14 of 29

Thiotaine

ERGOTHIONEINE AS AN ANTI-OXIDANT

THIOTAINE NEUTRALIZES OZONE

THIOTAINE INHIBITS MELANOGENESIS

Scav

engi

ng (%

)

Conc. Of EGT (µM)

Thiotaine Scavenges Superoxide Anion

Thiotaine Scavenges Simglet Oxygen

126 128 130

Control

EGT-20

EGT-10

Field (ml)

Ergothioneine Neutralizes Ozone

Trolox Vitamin-C

Trolox + Vit. C Ergothioneine Lipoic Acid

The information contained in this technical bulletin is, to the best of our knowledge, true and accurate. No warranty, expressed or implied is made or intended. The use should be based upon the customer's own investigations and appraisal. No recommendation should be construed as an inducement to use a material in infringement of patents or applicable government regulations.

Inhibition of Purified Tyrosinase of B16 Cells

% T

yros

inas

e R

ate

Tyrosinase Inhibition @ 50% is achieved with 150 um/ml Mel

anin

Syn

thes

is in

ug/

cell

Inhibition of Melanogenesis in Mouse Clouman S91 Cells

9 (µM) IBMX; 0 Thiotaine



50% inhibition with 200 ppm Thiotaine

All test results are available in detail upon request of the dossier.


15 of 29

NET-Tocotrienols - preliminary

Anti-Inflammatory Effect of Net-Tocotrienols

Suppression of inflammatory mediators’ increase induced by UV (prostaglandin E2 and interleukin-1)

PROPERTIES Vitamin E is one of the most important phytonutrients in edible oils. It consists of eight isomers, a family of four tocopherols (alpha, beta, gamma and delta) and four tocotrienols (alpha, beta, gamma and delta). Each tocotrienol (alpha or beta or gamma or delta-tocotrienol) is of importance in its own way. They work synergistically as a team to confer the maximum benefits. Tocotrienols show considerably superior antioxidant properties compared to dl-a-Tocopherol in clinical and experimental studies due to their better distribution in the fatty layers of the cell membrane. Tested in vitro at 5mg/mL, NET-Tocotrienols was shown to reduce PGE2 by 60% and IL-1 release by 20%. As a result, melanocyte activation index is reduced by almost 15% and melanocyte production is decreased. In vivo at 1%, NET-Tocotrienols compares to 3% VCPNa.

Concentration (mg/mL)


PGE-

2 (p

g/µg

pro

tein

)

IL-1

a(pg

/µg

prot

ein)

0 2.5 5 0 2.5 5


16 of 29

NET-Tocotrienols - preliminary

suppression of melanocyte activation in epidermal cells

Whitening Effect in 3D

Skin Lightening in vivo

Melanocyte

Activation Index (%

Control)

0 mg/mL 0 mg/mL 2 mg/mL 8 mg/mL 4 mg/mL


Content (%)

0 0.5 1.0 3.0

Mel

anin

Con

tent

s (m

g/w

ell)

Survival (% C

ontrol)

Pigmentation level (21 subjects; MED x 1.5). Test creams were applied on irradiated area of skin immediately after irradiation twice daily. Results after 1 week of treatment are shown in the graph.

Light

0.8

0.6

1.6

1.4

1.0

1.2

0.4

0.2

0.0

Pigm

enta

tion

Dark

Efficacy Report 2010

17 of 29

NET-DG

PROPERTIES

NET DG is an anti-inflammatory which can play an important role in formulating toady's "sensitive skin" treatments. It has been tested in vitro to demonstrate anti-inflammatory effects, anti-hyaluronidase activity, UV-erythema reduction, inhibition of histamine release, and effect on arachidonic cascade (LTB4, PGE2). Anti-inflammatories such as NET DG are now commonly used as a standard 'fourth phase" in Japanese emulsions for skin and hair care.


18 of 29

NET-HA 100

PROPERTIES

In its natural form, Hyaluronic Acid (HA) typically exists as a sodium salt (Sodium Hyaluronate). When mixed with water, it forms a viscous fluid. NET-HA 100's ability to bind water makes it an excellent choice as a moisturizer in cosmetic formulations.


19 of 29

AcquaCell – preliminary report

PROPERTIES

Tested on 20 subjects at 3%, AcquaCell provided 24 hours' skin hydration with one simple application and significantly reduced fine lines after 2 hours.

With one simple application, AcquaCell increased the cell membrane fluidity by 40%. Membrane fluidity is typical of young and healthy skin; the more unsaponifiables in the lipidic bilayer, the better. A diet based on meat increases saturated fatty acid supply and decreases the rigidity of membranes. Rigidity comes with aging.

AcquaCell upregulates filaggrin by 123% and AQP3 by 144%.

In two weeks at 3%, AcquaCell increased the water retained by corneocytes by 85%.

Tested for 2 weeks, AcquaCell dramatically increased key elements in the skin: Citrulline by 440%, Sodium PCA by 180%, Sodium Lactate by 60%. Moisture in the skin increased by 35%, dryness decreased by 60% and skin cohesion increased by 50%.

IMMEDIATE HYDRATION WITH ACQUACELL

A single application of 3% AcquaCell (in a gel vehicle) provided 24 hours of skin hydration compared to placebo.

Placebo 3% AcquaCell 1% AcquaCell

Skin

Im

peda

nce

DPM

Val

ues


20 of 29

AcquaCell – preliminary report

AcquaCell Reduces Flakiness in the Sun

REDUCTION OF DRYNESS ON LEGS

After 10 days, AcquaCell reduced flakiness in the skin (evaluation by dermatologists - score from 1 to 5) by over 60%.

Day 0

Scor

e

Day 2 Day 1 Day 3 Day 5 Day 10

ACQUACELL INCREASES KEY MOISTURIZING ELEMENTS OF THE STRATUM CORNEUM

Sodium Lactate Citruline Sodium PCA


21 of 29

AcquaCell

PROPERTIES

AcquaCell is a natural complex combining watermelon rind extract, Lens Esculenta (Lentil) Fruit Extract and unripened apple and apple skin in an optimized delivery system. Watermelon rind is one of nature's few materials to contain citrulline. Citrulline is essential to the functioning of filaggrin which forms a critical part of the skin's own water based moisturizing complex. The lentil extract contains vitamin B5 and trisaccharides. The apple starch is a source of polysaccharides, sodium lactate and sodium PCA.

1. REDUCES FINE LINES IN 2 HOURS 2. INCREASES INTRACELLULAR WATER BY 85% IN 2 WEEKS 3. INCREASES SODIUM PCA BY 150% AND CITRULLINE BY

450% IN 2 WEEKS 4. FOURTEEN TESTS TO PROVE EFFICACY

Test 2: Water Desorption Loss of 90% Water

Control X4

AcquaCell Treated

Test 1: Cellular Hydration 1. 20 subjects, 60 or older with dry and scaly, whitish looking skin

2. Two weeks on legs

3. Twice Daily

4. 3% Use Level

Cells recovered from shave biopsies Water Uptake / Holding: 85%


22 of 29

AcquaCell

Three Microassay Results on Fibroblasts

AQP3 Filaggrin Trichohyalin

+144% +123% +104%

Test 6a: Immediate Skin hydration – 15 minutes

% of AcquaCell


Skin

Im

peda

nce

DPM

Val

ues


23 of 29

AcquaCell

Test 6b: 24 hour hydration – single application

Test 6: Immediate Skin hydration


Skin

Im

peda

nce

DPM

Val

ues

Before AcquaCell After 2 hours, 3% AcquaCell


24 of 29

AcquaCell

Test 7: INTRINSIC SKIN HYDRATION:

The skin's natural ability to retain moisture independent of the application of any topical product. It is mainly related to the integrity of the stratum corneum barrier, and skin lipid production.

AcquaCell Hydration vs. Placebo

Day 1 Day 7 Day 3 Day 14

Before AcquaCell After 3% AcquaCell, 2 weeks


25 of 29

AcquaCell

Test 8: Skin Cohesiveness by Skin Taping

Test 9: Dermatologist Assessment of dryness on Legs

1. – Slight Flaking 2. – Moderate Flaking 3. – Marked Scaling 4. – Severe Scaling

Test Material Conc. BL Day 1 Day 2 Day 3 Day 5 Day 10

Placebo Gel 0% 2.7 2.74 2.71 2.6 2.77 2.66

AcquaCell 3% 2.74 2.42 2.37 1.75 1.4 1.05

% Improvement* 12% 13% 35% 50% 61%

Ligh

t Tr

ansm

issi

on –

LED

Uni

ts

1. Untreated 1. With 3% AcquaCell

Day 0 Day 7 Day 1 Day 14

* Data presented are averages of at least 20 subjects and based on a 0-‐4 point scale described above. Data highlighted in yellow are statistically significant.


26 of 29

AcquaCell

Test 10: Dermatologist Assessment of Redness, skin irritation on Legs

1. – Minimal 2. – Moderate 3. – Severe 4. – Fiery Red

Test Material Conc. BL Day 1 Day 2 Day 3 Day 5 Day 10

Placebo Gel 0% 1.8 1.78 1.82 1.87 1.92 1.89

AcquaCell 3% 1.82 1.7 1.64 1.58 1.47 1.32

% Improvement* 5% 10% 16% 24% 30%

* Data presented are averages of at least 20 subjects and based on a 0-‐4 point scale described above. Data highlighted in yellow are statistically significant.

Before AcquaCell After 2 Weeks with AcquaCell


27 of 29

AcquaCell

Test 11: Acquacell components

After 2 weeks’ use of key AcquaCell Components

Sodium Lactate Citruline Sodium PCA

Acquacell efficacy conclusion:

AcquaCell is the most-tested moisturizer presented in the cosmetic industry. AcquaCell works from within the skin and from the outside. It works 'immediately, in addition to long term.


28 of 29

Triple A Complex

PROPERTIES

Triple A Complex was tested in vivo on 20 subjects.

1. Used at 5% twice a day for 7 days, Triple A Complex reduced irritation (induced by 8% Lactic Acid) by more than 68%.

2. Used at 1% for 30 minutes, Triple A Complex reduced irritation (induced by 10% Balsam of Peru) by 90%.

3. Used at 5% for 2 weeks, results show that Triple A Complex reduced erythema (induced by UC) similar to an SPF 8 sunscreen cream.

REDUCTION OF LACTIC ACID IRRITATION

A 5% TAC solution was applied to one side of the face of 20 subjects; twice daily for 7 days while a placebo was applied to the other side. After the 7 day treatment, 8% Lactic Acid at pH 3 was applied to the nasal fold as described previously and results were compared with stinging scores obtained at the start of the experiment. While the placebo had no effect on stinging, chronic treatment with 5% TAC dramatically reduced stinging by more than 68%.

5% TAC Placebo

After 2X/Day – 7-Day Application

% R

educ

tion

in S

kin

Irri

tati

on


29 of 29

Triple A Complex

REDUCTION OF BALSAM OF PERU IRRITATION

10% Balsam of Peru was patched under occlusion on the backs of volunteers of 20 subjects for 30 minutes. Prior to patching or immediately after, a 1%, 3% and 5% solution of TAC were applied to the test sites. Skin erythema was graded by 2 clinicians on a 0-10 point scale 30 minutes after the patches were removed.

PREVENTION OF UV DAMAGE

A UV exposure of approximately 1 Med with a Xenon short arc light source was induced on the forearm of 20 subjects every other day for a two-week period. Sites were treated 30 minutes prior to exposure with either an SPF 8 sunscreen, 1% TAC, 3% TAC, or with 5% TAC, while the untreated site served as a control. At the end of two weeks, 24 hours after the last UV exposure erythema was evaluated both clinically and with a Perimed Periflux PF3 laser doppler.

% R

educ

tion

in S

kin

Irri

tati

on

1. Before Patching 1. After Patching

Sunscreen 2. Laser Doppler 3. Clinical

% R

educ

tion

in S

kin

Eryt

hem

a

The information contained in this technical bulletin is, to the best of our knowledge, true and accurate. No warranty, expressed or implied is made or intended. The use should be based upon the customer's own investigations and appraisal. No recommendation should be construed as an inducement to use a material in infringement of patents or applicable government regulations.

Documents

AspireLIFE Efficacy Report aug 2012 - Shopify · caused by oxidative stress and urban pollution. ! Efficacy Report - 2010! ... Merospheres is liposomal Ursolic Acid (URA) that stimulates