13
Coordination Chemistry Reviews, 112 (1992) 33-45 Elsevier Science Publishers B.V., Amsterdam 33 Aspects of the bioinorganic chemistry of aluminium(II1 ) relevant to the metal toxicity B. Coraina, M. Nicolin ib and P. ZattaC aUniversitri di Padova, Dipartimento di Chimica Inorganica, Met allorganica ed Anali tica, v ia Marzolo 1, 35131 Padova (Italy ) bUniversitti di Padova, Dipartimento di Scienze Farmaceutiche, via Marzolo 17.35131 Padova (Italy) ‘Centro CNR per lo Studio della Biochimica e della Fisiologia delle Emocianine ed altre Metallo-Proteine, Dipartimento Biologico, via Trieste 75, 35131 Padov a (Italy) (Received 1 April 1991) CONTENTS A. Introduction ......................... B. Speciation of Al(II1) in water and biological fluids . C. Al(III)/mod el-membrane and membrane molecules. D. AI(III)/neu rologically relevant amines and peptide s. E. Al(III)/ATP .......................... F. Al(III)/chromatin, purified DNA ....... ..... 6. Al(III)/Mg(II)-dependent proteins. ........... H. Al(III)/iron proteins .................... I. A1(III)/calmodulin ..................... J. Conclusions ......................... Acknowledgements ....................... References ............................ 33 36 36 31 38 39 40 40 41 42 43 43 To what risks are we exposing ourselves esp eciall y in olde r age? What can the inorganic chemist say abo ut the bioche mistr y of aluminium? f I] A. INTRODUCTION An extensive and articulated body o f information demonstrates that Al(II1) is a toxic metal centre. In fact, abnormal exposure to Al(II1) is recognized as an etiological factor in alumino sis [2], dialysis, encephalopathy and osteodistrophy [2,3], and non-iron deficiency microcytic anaemia [4]. Moreover, analytical observa- tions [S] and epidemiological data [6] poi nt to an implication of abnormal accumula- tion (and uptake?) of Al(II1) as a significant marker of Alzheimer’s di sease. Convincing evidence for the internatio nal scientific awareness of the implication of Al(II1) in biological systems is offered by the exponential growth of the number of papers appearing in the period 1970-1990 (Fig. 1) and quoted in B iologic al Abstracts. OOIO-8545/92/$15.00 0 1992 Elsevier Science Publishers B.V. All rights reserved.

Aspects of the Bioinorganic Chemistry of of aluminium (iii) relevent to the metal toxicity

Embed Size (px)

Citation preview

8/8/2019 Aspects of the Bioinorganic Chemistry of of aluminium (iii) relevent to the metal toxicity

http://slidepdf.com/reader/full/aspects-of-the-bioinorganic-chemistry-of-of-aluminium-iii-relevent-to-the 1/13

8/8/2019 Aspects of the Bioinorganic Chemistry of of aluminium (iii) relevent to the metal toxicity

http://slidepdf.com/reader/full/aspects-of-the-bioinorganic-chemistry-of-of-aluminium-iii-relevent-to-the 2/13

8/8/2019 Aspects of the Bioinorganic Chemistry of of aluminium (iii) relevent to the metal toxicity

http://slidepdf.com/reader/full/aspects-of-the-bioinorganic-chemistry-of-of-aluminium-iii-relevent-to-the 3/13

8/8/2019 Aspects of the Bioinorganic Chemistry of of aluminium (iii) relevent to the metal toxicity

http://slidepdf.com/reader/full/aspects-of-the-bioinorganic-chemistry-of-of-aluminium-iii-relevent-to-the 4/13

8/8/2019 Aspects of the Bioinorganic Chemistry of of aluminium (iii) relevent to the metal toxicity

http://slidepdf.com/reader/full/aspects-of-the-bioinorganic-chemistry-of-of-aluminium-iii-relevent-to-the 5/13

8/8/2019 Aspects of the Bioinorganic Chemistry of of aluminium (iii) relevent to the metal toxicity

http://slidepdf.com/reader/full/aspects-of-the-bioinorganic-chemistry-of-of-aluminium-iii-relevent-to-the 6/13

8/8/2019 Aspects of the Bioinorganic Chemistry of of aluminium (iii) relevent to the metal toxicity

http://slidepdf.com/reader/full/aspects-of-the-bioinorganic-chemistry-of-of-aluminium-iii-relevent-to-the 7/13

8/8/2019 Aspects of the Bioinorganic Chemistry of of aluminium (iii) relevent to the metal toxicity

http://slidepdf.com/reader/full/aspects-of-the-bioinorganic-chemistry-of-of-aluminium-iii-relevent-to-the 8/13

8/8/2019 Aspects of the Bioinorganic Chemistry of of aluminium (iii) relevent to the metal toxicity

http://slidepdf.com/reader/full/aspects-of-the-bioinorganic-chemistry-of-of-aluminium-iii-relevent-to-the 9/13

8/8/2019 Aspects of the Bioinorganic Chemistry of of aluminium (iii) relevent to the metal toxicity

http://slidepdf.com/reader/full/aspects-of-the-bioinorganic-chemistry-of-of-aluminium-iii-relevent-to-the 10/13

8/8/2019 Aspects of the Bioinorganic Chemistry of of aluminium (iii) relevent to the metal toxicity

http://slidepdf.com/reader/full/aspects-of-the-bioinorganic-chemistry-of-of-aluminium-iii-relevent-to-the 11/13

8/8/2019 Aspects of the Bioinorganic Chemistry of of aluminium (iii) relevent to the metal toxicity

http://slidepdf.com/reader/full/aspects-of-the-bioinorganic-chemistry-of-of-aluminium-iii-relevent-to-the 12/13

8/8/2019 Aspects of the Bioinorganic Chemistry of of aluminium (iii) relevent to the metal toxicity

http://slidepdf.com/reader/full/aspects-of-the-bioinorganic-chemistry-of-of-aluminium-iii-relevent-to-the 13/13