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Smart Sensor Systems for Invasive
Pressure Monitoring
Wilfried Mokwa
Institute of Materials in Electrical Engineering I (IWE I)
RWTH Aachen University, Germany
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 2
intravascular
pressure bladder
pressure
gastric/intestinal
pressure
intraocular pressure intracranial pressure
Intracorporal Pressure Measurement
pressure in abdominal
aortic aneurysm
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 3
Surface Micromachined Capacitive Pressure Sensor
A miniaturized plate capacitor for pressure measurement
-> miniaturization and low power consumption
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 4
CMOS integration
• Integrated capacitive pressure sensor on
8“-wafer using surface micromachining
-> integrated single chip solution
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 5
• Intracranial Pressure Measurement
• Intravasacular Pressure Monitoring System
• Conclusions
Intracorporal Pressure Measurement
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 6
• Intra Cranial Pressure Measurement
• Intravasacular Pressure Monitoring System
• Conclusions
Intracorporal Pressure Measurement
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 7
1 Cranium
2 Brain
3 Side ventricle
4 Third ventricle
5 Cerebrospinal fluid
6 Fourth ventricle
Anatomy of the Brain
Intracranial Pressure Measurement
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 8
child with hydocephalus healthy child
ventrikular-peritoneale shunt
Intracranial Pressure Measurement
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 9
ventricular-peritoneal shunt with externally adjustable valve
Christoph Miethke GmbH & Co. KG
Intracranial Pressure Measurement
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 10
ventricular shunt with externally
adjustable valve and integrated
pressure measurement
HFDigital Part
EEPROMPressure Sensor
SensorReadout
Biasing &
Voltage Regulat.
Monolithically integrated capacitive
pressure sensors
Intracranial Pressure Measurement
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 11
Telemetric read out system
Intracranial Pressure Measurement
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 12
• Intra Cranial Pressure Measurement
• Intravasacular Pressure Monitoring System
• Conclusions
Intracorporal Pressure Measurement
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 13
Intravascular monitoring system for hypertonia (HYPER-IMS)
• In Germany approximately 10
million people suffer from
hypertension (highly
increased blood pressure)
• About 10% of them have
problems to control their
blood pressure
• Approximately 10% of this
group are candidates for a
longterm-pressure-monitoring
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 14
Arteria
Femoralis
Sensor tip
Implantable, wireless
long-term monitoring
system (24 hours / 7 days)
for:
blood pressure
heart frequency
blood pulse
cardiac rhythm
Subcutaneous transponder
Intravascular monitoring system for hypertonia (HYPER-IMS)
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 15
ø 3 F ≈ 1 mm
Intravascular monitoring system for hypertonia (HYPER-IMS)
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 16
Reference meassurement with Mammendorfer Sensor immediatily after implantation
55
60
65
70
75
80
85
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
time (sec)
blo
od
pre
ssu
re (
mm
Hg
)
HIMS 4614
MD-Sensor
System test
implantation of the sensor-tip into the arteria
femoralis of a sheap
subcutaneous placement of the transponder unit
acute and chronic in-vivo testing
Intravascular monitoring system for hypertonia (HYPER-IMS)
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 17
• Intra Cranial Pressure Measurement
• Intravasacular Pressure Monitoring System
• Conclusions
Intracorporal Pressure Measurement
Sensor Systems for Invasive Pressure Monitoring
Wilfried Mokwa 18
Conclusions
By microsystem technology systems can strongly be miniaturized so
that implantation becomes possible
New applications will be possible (e.g. implants to measure and regulate
brain pressure as one example)
In future intelligent implants and protheses will support strongly the
field of "home care“
This work was partly funded by the German Ministry
of Education and Research
Long term stability of flexible “intelligent” implants
Further miniaturization
Energy harvesting
Assumption of cost by health insurances
Challenges