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As A Biotherapeutic Agent In
Clinical Nutrition
As A Biotherapeutic Agent In
Clinical Nutrition
Microbial Cell PreparationMicrobial Cell Preparation
Efficacy EstablishedEfficacy Established
Scientifically Proven Safe For ConsumptionScientifically Proven Safe For Consumption
Palatable FlavourPalatable Flavour
No Reported Side EffectNo Reported Side Effect
Registered With National Pharmaceutical Registered With National Pharmaceutical
Control BureauControl Bureau
ABSORPTIONABSORPTION ABSORPTIONABSORPTION
CLINICALCLINICAL
NUTRITIONNUTRITIONCLINICALCLINICAL
NUTRITIONNUTRITION
IMPROVEIMPROVE
QOLQOLIMPROVEIMPROVE
QOLQOL
& Constipation
Pathophysiology ofPathophysiology ofConstipationConstipation
Aged Population
PregnantMothers
BedRiddenPatients
Premature Babies
Vulnerable Vulnerable GroupsGroups
Travelling Individual
Medication
Stress
Laxative Abuse
• Hemorrhoids • Anal fissure • Diarrhea • Fecal incontinence • Rectal bleeding
• Rectal prolapse • Rectal hernia• Fecal impaction • Uterine hernia • Uterine prolapse
Prolonged Constipation Prolonged Constipation
May Lead To:May Lead To:
www.wrongdiagnosis.com
Prolong Constipation:Prolong Constipation:HemorrhoidsHemorrhoids
Prolong Constipation:Prolong Constipation:HemorrhoidsHemorrhoids
Rectal ProlapseRectal ProlapseRectal ProlapseRectal Prolapse Rectal BleedingRectal BleedingRectal BleedingRectal Bleeding
Anal FissureAnal FissureAnal FissureAnal Fissure Uterine ProlapseUterine ProlapseUterine ProlapseUterine Prolapse
Hexbio Improves Chronic Constipation
Number of patients according to gender
The study of “Efficacy of in Improving Chronic Constipation” was conducted in 12 patients consisting of 5 males and 7 females. Figure shows the total of patients (N)
involved in the study according to gender.
The study of “Efficacy of in Improving Chronic Constipation” was conducted in 12 patients consisting of 5 males and 7 females. Figure shows the total of patients (N)
involved in the study according to gender.
Years of constipation
Age of patients
22 83
2 31
Chart shows the age of the patients ranging from 22 to 83 years old and the years each patients suffer from constipation ranging from 2 to 31 years.
Age of patients and years of constipation
years 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85
Results
Above graph shows the frequency of stools during the study period of 7 days. According to the results, stool frequency increased from 1.4 time a week before treatment to 4.3 a week after treatment. This indicates the efficacy of in increasing patients’ bowel
movement and reduces constipation.
Above graph shows the frequency of stools during the study period of 7 days. According to the results, stool frequency increased from 1.4 time a week before treatment to 4.3 a week after treatment. This indicates the efficacy of in increasing patients’ bowel
movement and reduces constipation.
Stool frequency per week
p = 0.001
Stool frequency
Role of Probiotic Mixture In Treatment Of Role of Probiotic Mixture In Treatment Of Childhood ConstipationChildhood Constipation
The probiotic mixture was contained Bifidobacterium and lactobacillus. Frequency of Bowel Movement (BM) per week in 20 children we tested. According to the chart, the
frequency of BMs in overall children increased in each week showing that the administration of probiotic mixture had a positive effect on frequency of BM.
The probiotic mixture was contained Bifidobacterium and lactobacillus. Frequency of Bowel Movement (BM) per week in 20 children we tested. According to the chart, the
frequency of BMs in overall children increased in each week showing that the administration of probiotic mixture had a positive effect on frequency of BM.
The role of probiotics mixture in the treatment of childhood constipation : a pilot study. Noor-L-Huada Bekkali, Marloes EJ Bongers, Maartje M Van den Berg, Olivia Liem and Marc A Benniga. Netherlands. Published in 4 August 2007.
2.0
4. 2 3.8
Frequency of Bowel MovementFrequency of Bowel Movement
A study to determine the prevalence of IBS and to assess the symptoms subgroups in young adult Malaysians was done. The results obtained had been categorized into few subgroups of symptoms as shown above. As conclusion, within the IBS population, the
majority (77.4%) was of the constipation-predominant IBS subgroup.
A study to determine the prevalence of IBS and to assess the symptoms subgroups in young adult Malaysians was done. The results obtained had been categorized into few subgroups of symptoms as shown above. As conclusion, within the IBS population, the
majority (77.4%) was of the constipation-predominant IBS subgroup.
Prevalence of irritable bowel syndrome in young adult Malaysians: A survey among medical students. Tan, Yan-mei; Goh, Khean L; Muhidayah, Raja; Ooi, Chee L; Salem, Omar. Department of Medicine, Faculty of Medicine, University of Malaya.
Prevalence of Irritable Bowel Syndrome on young adult. Prevalence of Irritable Bowel Syndrome on young adult. Malaysian: A survey among Medical StudentsMalaysian: A survey among Medical Students
HOW HELPCONSTIPATION???
Bekkali et. al. (2007). The role of probiotics mixture in the treatment of childhood constipation: a pilot study. Nutrition Journal 6: 17.
Secretes organic acids, maintaining acidic environment that induce peristalsis.
Regularize bowel movement and shortens the Colonic Transit Time.
Mechanism Mechanism of Actionof Action
Provide Provide AcidicAcidic
EnvironmentEnvironment
ShortenShortenColonic Transit Colonic Transit
TimeTime
Induce Induce PeristalsisPeristalsis
Increase Increase Bowel MovementBowel Movement
FrequencyFrequency
FacilitateFacilitateSmootherSmootherDefecationDefecation
& Diarrhea
Is Like A Storm Is Like A Storm Raging Inside Raging Inside
You & Its You & Its Shows Up At Shows Up At
The Most The Most Unexpected Unexpected
Time Time
Diarrhea
Frequent loose or liquid bowel movements, often due to disruption of water absorption in the colon
Defense Mechanism
In the event of pathogenic infection, diarrhea functions as an evolved expulsion defense mechanism.
The appendix serves as a safe house for the good bacteria, protecting it from contamination and facilitating a re-start of the system once the contaminating organisms has been eliminated.
Type Condition Caused Efficacy, HEXBIO®
Secretory Secretory DiarrheaDiarrhea
Increase secretion activity or inhibition of absorption.
1. Cholera toxin N.A.
Osmotic Osmotic DiarrheaDiarrhea
Too much of water is drawn into the bowel, maldigestion.
1. Osmotic laxatives2. Malabsorption3. Lactose
intolerance
Selective
Motility-Related Motility-Related DiarrheaDiarrhea
Rapid movement of food through the intestines (hypermotility).
1. Menstruation2. Hyperthyroidism
N.A.
Inflammatory Inflammatory DiarrheaDiarrhea
Damage to the mucosal lining, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids.
1. Bacterial/ viral/ parasitic infection
2. Inflammatory bowel disease
3. Antibiotic treatment
4. Colon cancer
Most
Types of DiarrheaTypes of Diarrhea
Treatment of Acute Gastroenteritis in Infants Treatment of Acute Gastroenteritis in Infants (6-12 months)(6-12 months)
Raanan Shamir et. al, Evaluation of a diet containing probiotics for the treatment of mild diarrheal illness in children younger than one year of age, American College of Nutrition 2005; 24(Suppl. 5):370-375
From the study, 65 young children aged 6-12 months, suffering from acute gastroenteritis were From the study, 65 young children aged 6-12 months, suffering from acute gastroenteritis were treated daily until diarrhea resolution. As showed in the result, the feeding of microbial cell treated daily until diarrhea resolution. As showed in the result, the feeding of microbial cell
preparation reduced the severity and duration of acute gastroenteritis in young children.preparation reduced the severity and duration of acute gastroenteritis in young children.
From the study, 65 young children aged 6-12 months, suffering from acute gastroenteritis were From the study, 65 young children aged 6-12 months, suffering from acute gastroenteritis were treated daily until diarrhea resolution. As showed in the result, the feeding of microbial cell treated daily until diarrhea resolution. As showed in the result, the feeding of microbial cell
preparation reduced the severity and duration of acute gastroenteritis in young children.preparation reduced the severity and duration of acute gastroenteritis in young children.
61 children that tested positive for rotavirus were treated with microbial cell 61 children that tested positive for rotavirus were treated with microbial cell preparation/placebo for 6 days. Stools were collected and examined again after 6 days of preparation/placebo for 6 days. Stools were collected and examined again after 6 days of treatment. In conclusion, oral administration of microbial cell preparation is effective in treatment. In conclusion, oral administration of microbial cell preparation is effective in
reducing the duration of rotavirus excretion. reducing the duration of rotavirus excretion.
61 children that tested positive for rotavirus were treated with microbial cell 61 children that tested positive for rotavirus were treated with microbial cell preparation/placebo for 6 days. Stools were collected and examined again after 6 days of preparation/placebo for 6 days. Stools were collected and examined again after 6 days of treatment. In conclusion, oral administration of microbial cell preparation is effective in treatment. In conclusion, oral administration of microbial cell preparation is effective in
reducing the duration of rotavirus excretion. reducing the duration of rotavirus excretion.
Guarino A et. al, Oral bacterial therapy reduces the duration of symptoms and of viral excretion in children with mild diarrhea,Department of Pediatrics, University Federico II of Naples, Italy
The largest meta-analysis to evaluate 34 different clinical trials involving 4844 patients.
Result:Reduced the likelihood of developing antibiotic-associated diarrhea by 52%.
Reduce Incidence of Reduce Incidence of Antibiotic Associated DiarrheaAntibiotic Associated Diarrhea
Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE. Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomized, placebo-controlled trials. Lancet Infect Dis. 2006;6:374-382.
Conclusion:
The benefits were most pronounced among children.
An analysis to evaluate 34 different clinical trials involving 4844 patients.
Result:Reduced the incidence of acute diarrhea by 34%.
Review:In 12 pediatric studies included in this analysis, it reduced the likelihood of acute diarrhea in children by 57% (p<0.001)
Reduce Incidence of Acute DiarrheaReduce Incidence of Acute Diarrhea
Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE. Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomized, placebo-controlled trials. Lancet Infect Dis. 2006;6:374-382.
Conclusion:
The benefits were most pronounced among children.
Combined Treatment (with ORS) of acute diarrhea in children
37 children aged 3 to 24 months received ORS as a form of rehydration, and were treated to microbial cell preparation at 12-hours interval until the resolution of diarrhea.
In conclusion, addition of microbial cell preparation to ORS was effective in the treatment of children with acute diarrhea by decreasing the duration of diarrhea.
37 children aged 3 to 24 months received ORS as a form of rehydration, and were treated to microbial cell preparation at 12-hours interval until the resolution of diarrhea.
In conclusion, addition of microbial cell preparation to ORS was effective in the treatment of children with acute diarrhea by decreasing the duration of diarrhea.
Simakachorn N. et. al, Clinical evaluation of the addition of lyophilized Lactobacillus LB to oral rehydration therapy in the treatment of acute diarrhea in children, Journal of Pediatric Gastroenterology and Nutrition 0277-2116
Hexbio® + ORS
Gilliland et. al. (2001). Health and nutritional properties of probiotics in foods including powder milk with live Lactic Acid Bacteria, WHO/FAO
HOW HELPDIARRHEA???
Mechanism of Action
Produce anti-microbial substances
Secretes lactase enzyme
Neutralize enterotoxins
from pathogen
Facilitate digestion of
lactose
Reduce rotavirus shedding
Suppress the replication of
virus
Neutralize enterotoxins from pathogens. Produce anti-microbial substances to
suppress the growth of pathogens. Reduce rotavirus shedding.
& Immunity
Common Cold – upper respiratory Common Cold – upper respiratory tract infection caused by either tract infection caused by either rhinoviruses or coronaviruses. rhinoviruses or coronaviruses.
Flu – infectious disease caused by Flu – infectious disease caused by Influenza viruses.Influenza viruses.
Cold and FluCold and Flu
HOW HELPto induce immunity???
Induces secretion of Immunoglobin A. Increase level of T-Lymphocyte cells as well as other
helper immune cells. Activate the human myeloid dendrite cell (MDC) to
induce immune response.
Mechanism of Action
Immunostimulation of mucosalmembrane
Increase Synthesis
of IgA
Increase Increase
T-LymphocytesT-LymphocytesActivate MDCActivate MDC
Stimulation of T-Lymphocyte LevelStimulation of T-Lymphocyte Level
125
90
0
20
40
60
80
100
120
140
T-Lymphocyte Level/10 pilli
Treatment Group Control Group
G. Perdigon et. al, Symposium: Probiotic bacteria for humans: Clinical systems for evaluation of effectiveness, Journal of Dairy Science
1995 78:1597-1606
Consumption of microbial cell preparation able to stimulate the level of T-Lymphocyte cells.
Reduction of Cold and Flu SymptomsReduction of Cold and Flu Symptoms
For 6 months, 326 children, aged 3 to 5 were For 6 months, 326 children, aged 3 to 5 were treated twice a day.treated twice a day.
Results:Results:
Probiotic Effects on cold and influenza-like symptom incidence and duration in children. American Academy of Pediatrics
Symptoms Incidence Rate
Treatment Group
Control Group
Cough 29.5% 83.7%
Fever 16.1% 63.5%
Microbial cell preparation reduces the incidence and severity of cold and flu symptoms in children.
& Other Diseases
STROKE
Chart shows the overall rates of complications in the Asian region. Among the non-neurologic complications, the most commonly encountered were chest infections, constipation and urinary retention with a rate of 19%, 15% and 11% respectively.
Chart shows the overall rates of complications in the Asian region. Among the non-neurologic complications, the most commonly encountered were chest infections, constipation and urinary retention with a rate of 19%, 15% and 11% respectively.
Complication of Acute Stroke : A study in Ten Asian countries. Jose C.Navvaro MD MSc et.al, Neurology Asia 2008; 13:33-39. University of Santo Thomas, Espana, Manila, Phillipines.
DIABETES
• Gastrointestinal Symptoms associated to Diabetic Complications.• Scientist state that 76% of DM patients undergo at least one
gastrointestinal problem and the majority of them suffer from constipation.• The percentage are as shown below:-
DIABETES
TYPE 1TYPE 1 Is a failure
of the pancreas to produce insulin
TYPE 2TYPE 2 Is insulin resistance
or impaired glucose tolerance
Diabetes Related GIT Symptoms
• Irritable Bowel Syndrome• Constipation• Dyschezia (Painful Defecation) • Diarrhea• Fecal incontinence• Dyspepsia
(Upset Stomach, Indigestion)• Nausea /vomiting• Heartburn
The chart pie above shows the prevalence of GI tract symptoms among patients The chart pie above shows the prevalence of GI tract symptoms among patients with DM type 1 compared to respective control. As showed above, the highest with DM type 1 compared to respective control. As showed above, the highest symptom stand of peripheral neuropathy for muscle numbness, continued by symptom stand of peripheral neuropathy for muscle numbness, continued by
dyspepsia and constipation which holds the third place with percentage of 16.7%.dyspepsia and constipation which holds the third place with percentage of 16.7%.
The chart pie above shows the prevalence of GI tract symptoms among patients The chart pie above shows the prevalence of GI tract symptoms among patients with DM type 1 compared to respective control. As showed above, the highest with DM type 1 compared to respective control. As showed above, the highest symptom stand of peripheral neuropathy for muscle numbness, continued by symptom stand of peripheral neuropathy for muscle numbness, continued by
dyspepsia and constipation which holds the third place with percentage of 16.7%.dyspepsia and constipation which holds the third place with percentage of 16.7%.
The chart pie above shows the prevalence of GI tract symptoms among patients The chart pie above shows the prevalence of GI tract symptoms among patients with DM type 2 compared to respective control. As showed above, the highest with DM type 2 compared to respective control. As showed above, the highest symptom is peripheral neuropathy with 51.6%, continued by heartburn 19.8%, symptom is peripheral neuropathy with 51.6%, continued by heartburn 19.8%,
dyspepsia 13.4% and constipation 10.1%.dyspepsia 13.4% and constipation 10.1%.
The chart pie above shows the prevalence of GI tract symptoms among patients The chart pie above shows the prevalence of GI tract symptoms among patients with DM type 2 compared to respective control. As showed above, the highest with DM type 2 compared to respective control. As showed above, the highest symptom is peripheral neuropathy with 51.6%, continued by heartburn 19.8%, symptom is peripheral neuropathy with 51.6%, continued by heartburn 19.8%,
dyspepsia 13.4% and constipation 10.1%.dyspepsia 13.4% and constipation 10.1%.
COLON CANCER
DEFECATION.. Is not evaluated
according to HOW MANY times
we defecate..
It is evaluated according to the
TYPES of stool that been eliminated..
Types of Stool
Evaluation Of Stool
Constipation
Normal
Diarrhea
Bristol Stool Chart
Bowel Movement (BM) Frequency and Risk of Colorectal Cancer in a Large Cohort Study of Japanese Men and Women
IRR
BM
Above chart shows the average Incidence Rate Ratios (IRR) for colorectal and colon cancer according Above chart shows the average Incidence Rate Ratios (IRR) for colorectal and colon cancer according to BM frequency. As shown, it is the best to have BM every 2-3 days as it shows the lowest IRR. Too to BM frequency. As shown, it is the best to have BM every 2-3 days as it shows the lowest IRR. Too often of BM per day can cause higher risk of colon and colorectal cancer. This is the same with BM often of BM per day can cause higher risk of colon and colorectal cancer. This is the same with BM
every 6 days or less which has IRR of 1.81 average for both men and women.every 6 days or less which has IRR of 1.81 average for both men and women.
Above chart shows the average Incidence Rate Ratios (IRR) for colorectal and colon cancer according Above chart shows the average Incidence Rate Ratios (IRR) for colorectal and colon cancer according to BM frequency. As shown, it is the best to have BM every 2-3 days as it shows the lowest IRR. Too to BM frequency. As shown, it is the best to have BM every 2-3 days as it shows the lowest IRR. Too often of BM per day can cause higher risk of colon and colorectal cancer. This is the same with BM often of BM per day can cause higher risk of colon and colorectal cancer. This is the same with BM
every 6 days or less which has IRR of 1.81 average for both men and women.every 6 days or less which has IRR of 1.81 average for both men and women.
British Journal of Cancer (2004) 90, 1397-1401
Colon CancerColon Cancer
SafetySafety
Acute Oral Toxicity Test for Hexbio was done in TÜV SÜD PSB Singapore to find out the Adverse Effect of Hexbio.
Necropsy Result shows there is no weight & colour change of the liver.
SafetySafetySafetySafety
Nutrition Fact
Content Unit
Protein gram per sachet 0.16
Fat gram per sachet 0
Fiber gram per sachet 0
Carbohydrate gram per sachet 2.7
Calories gram per sachet 11.6
* Hexbio* Hexbio®® is safe for all type of patients’ consumption since the Carbohydrate and the Calories are in the safe range for everybody
SleepingSleeping
ActivityActivity
AppetiteAppetite
PsychologyPsychology
Hexbio In Balancing QOLHexbio In Balancing QOL
When there is Constipation; Diarrhea; Cold or FluWhen there is Constipation; Diarrhea; Cold or Flu
Our normal daily activities (as mentioned) will be disturbed.Our normal daily activities (as mentioned) will be disturbed.
Hexbio is here to overcome the symptoms and improve the Quality of Life!Hexbio is here to overcome the symptoms and improve the Quality of Life!
HOW TO USE ?HOW TO USE ?
WHEN TO USE ?WHEN TO USE ?
Consume:1 sachet during each meal
• Breakfast Breakfast • DinnerDinner
As a good treatment; For good absorption of nutrients;
and for faster recovery
Hexbio can function at BOTH small intestine & large intestine
2. Liquid Dose
1 sachet (3g) to 5ml water/juices/energy drinks/milk
Pour 1 sachet into 5ml water
Stir to mix Feed using syringe
1. Oral Dose
Consume 2 sachets during Breakfast & Dinner eachby directly pour into the mouth
DosageDosage
Before any patient
been discharged, it
is very important
for a Medical
Practitioner to
ensure that the
patient’s bowel
movement is
smooth and able to
have good
absorption of
nutrient, for a
promising
RECOVERY!
Thank You!Thank You!
B-CROBES MARKETING (M) SDN. BHD.B-CROBES MARKETING (M) SDN. BHD.