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SUPPLEMENTAL MATERIAL
Sevoflurane versus total intravenous anesthesia for isolated coronary artery bypass surgery with
cardiopulmonary bypass: a randomized trial.
AUTHORS: Valery V. Likhvantsev, Giovanni Landoni, Dmitry I. Levikov, Oleg A. Grebenchikov,
Yuri V. Skripkin, Rostislav A. Cherpakov
CONTENTS
Supplemental Table 1. Univariate and multivariate predictors of length of hospital stay p2
Supplemental Table 2. Univariate and multivariate predictors of 1 year mortality p3
Supplemental Table 3. Univariate and multivariate predictors of 30 day mortality p4
Supplemental Table 4. Univariate and multivariate predictors of 7 day mortality p5
1
Supplemental Table 2. Univariate and multivariate predictors of length of hospital stay
P-value
Univariate
P-value
Multivariate
Point Estimation
(95% Conf. Interval)
Pre-operative data
Gender; female 0.25
Age; years 0.50
Weight; kg 0.59
Ejection Fraction 0.030 0.009 -0.06 (-0.097;-0.014)
Previous myocardial infarction 0.0035 0.017 0.75 (0.13; 1.38)
Arrhythmia (other than sinus or premature atrial contractions)
0.16 NS
Diabetes mellitus 0.32
EuroScore II 0.0098 0.027 1.51 (0.17;2.86)
NT-proBNP, pg.ml-1 <0.001 =0.001 0.002 (0.001;0.003)
Randomization (sevoflurane) <0.001 <0.001 -3.96 (-4.48;-3.44)
Intra-operative data
Surgery duration 0.89
Cardiopulmonary bypass time 0.91
Aortic clamp time 0.28
Distal grafts 0.94
2
Supplemental Table 2. Univariate and multivariate predictors of 1 year mortality
P-value
Univariate
P-value
Multivariate
Point Estimation
(95% Conf. Interval)
Pre-operative data
Gender; female 0.56
Age; years 0.37
Weight; kg 0.65
Ejection Fraction 0.13 <0.01 0.95 (0.94;0.97)
Previous myocardial infarction <0.01 <0.01 2.35 (1.32;4.20)
Arrhythmia (other than sinus or premature atrial contractions)
0.90
Diabetes mellitus 0.72
EuroScore II <0.01 0.076 2.04 (0.93;4.50)
NT-proBNP, pg.ml-1 <0.01 <0.01 1.002 (1.001;1.003)
Randomization (sevoflurane) 0.034 0.028 0.64 (0.42;0.95)
Intra-operative data
Surgery duration 0.70
Cardiopulmonary bypass time 0.17 NS
Aortic clamp time 0.63
Distal grafts 0.51
3
Supplemental Table 3. Univariate and multivariate predictors of 30 day mortality
P-value
Univariate
P-value
Multivariate
Point Estimation
(95% Conf. Interval)
Pre-operative data
Gender; female 0.61
Age; years 0.67
Weight; kg 0.32
Ejection Fraction 0.34
Previous myocardial infarction 0.075 NS
Arrhythmia (other than sinus or premature atrial contractions)
0.76
Diabetes mellitus 0.23
EuroScore II <0.01 0.064 3.48 (0.93;13.02)
NT-proBNP, pg.ml-1 <0.01 0.005 1.001 (1.000;1.002)
Randomization (sevoflurane) 0.58 0.045 0.53 (0.29;0.99)
Intra-operative data
Surgery duration 0.53
Cardiopulmonary bypass time 0.43
Aortic clamp time 0.46
Distal grafts 0.18 <0.001 0.20 (0.12;0.36)
4
Supplemental Table 4. Univariate and multivariate predictors of 7 day mortality
P-value
Univariate
P-value
Multivariate
Point Estimation
(95% Conf. Interval)
Pre-operative data
Gender; female 0.99
Age; years 0.58
Weight; kg 0.28
Ejection Fraction 0.006 <0.001 0.89 (0.85;0.93)
Previous myocardial infarction 0.99
Arrhythmia (other than sinus or premature atrial contractions)
0.99
Diabetes mellitus 0.99
EuroScore II 0.21
NT-proBNP, pg.ml-1 0.021 0.046 1.001 (1.000;1.003)
Randomization (sevoflurane) 0.57 NS
Intra-operative data
Surgery duration 0.30
Cardiopulmonary bypass time 0.17 NS
Aortic clamp time 0.45
Distal grafts 0.31
5
