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eAppendix 1. Full electronic search strategy for Medline OvidSP, 25th June 2015
1. independent* prescrib*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]2. supplementary prescrib*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]3. nurs* prescrib*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]4. pharmac* prescrib*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]5. podiatr* prescrib*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]6. chiropad* prescrib*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]7. radiograph* prescrib*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]8. optometr* prescrib*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]9. physiotherap* prescrib*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]10. physio* prescrib*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]11. autonomous prescrib*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]12. prescription/13. non-medical prescrib*.mp.14. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 1315. Facilitator*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]16. Success*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]17. Value*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]18. Advantag*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease
supplementary concept word, unique identifier]19. Patient satisfaction.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]20. Patient experience.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]21. Implementation.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]22. patient satisfaction/23. (Organisation and management).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]24. 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 2325. 14 and 2426. Barrier*.mp.27. Safety issue*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]28. Education*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]29. Obstacle*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]30. Failure*.mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]31. education/32. medication error/33. drug safety/34. patient safety/35. 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 3436. 14 and 3537. 25 or 3638. limit 37 to (human and English language and yr="1994 - 2015")39. 14 and 1540. 14 and 2641. 39 or 4042. limit 41 to (human and English language and yr="1994 -Current")
Table 2 Included qualitative studies and characteristics.
Study Design Country NMP profession Healthcare setting
Healthcare specialty
Participants
Avery et al, 200732
Surveys and Interviews
UK (England)
Nurses, Pharmacists
Community care,Hospital care
Range of Specialties
Total n = 110Surveys n = 85: Nurses n = 80, Midwives n = 3, Pharmacists n = 2,Interviewed n = 25: Nurses n = 16, Doctors n = 5, Pharmacist n = 1, Managers n = 3,
Bennett and Jones, 200845
Surveys and Focus Groups
UK Nurses Community care
HIV Total n = 8Surveys: Nurses n = 8Focus Groups: Nurses n = 8
Bradley and Nolan, 200751
Interviews UK Nurses Community care,Hospital care
Range of Specialties
Total n = 45Nurses n = 45, Face-to-face interview n = 31, Telephone interview n = 14
Bradley et al, 200836
Focus Groups UK Nurses Community care,Hospital care
Mental Health
Total n = 15Nurses n = 15
Carey et al, 200937
Interviews UK Nurses Hospital care Paediatrics Total n = 21Nurses n = 7, Doctors n = 11, Managers n = 3
Carey et al, 201038
Interviews UK (England)
Nurses Community care
Dermatology
Total n = 40Nurses (prescribers) n = 11, Doctors n = 12, Admin Staff n = 11, Nurses (Non-prescribers) n = 6
Courtenay and Carey, 200939
Interviews UK (England)
Nurses Hospital care Paediatrics Total n = 14Nurse prescribers n = 7, Doctors (consultant level) n = 4, Managers n = 3
Courtenay et al, 201133
Interviews UK (England)
Community-practitioner
Community care,
Range of Specialties
Total n = 28NMP leads n = 28
prescribers, Pharmacists,Nurses, Physiotherapists, Podiatrists, Optometrists
Hospital care
Cousins and Donnell, 201262
Interviews UK (England)
Nurses Community care
General Practice
Total n = 6Nurses n = 6
Downer and Shepherd, 201055
Interviews UK (Scotland)
Nurses Community care
District nursing
Total n = 8District nurses n = 8
Earle et al, 201157
Interviews UK (England)
Nurses Community care
Mental Health
Total n = 8Nurse prescribers n = 2, Service users n = 6
Glod and Manchester, 200048
Surveys USA Nurses Community careHospital care
Mental Health
Total n = 1352Advance practice nurses n = 1352
Guirguis et al, 201474
Interviews Canada Pharmacists Community care
Range of Specialties
Total n = 38Pharmacist prescribers n = 13, Non-prescribing pharmacists n = 25
Hales, 200256 Surveys USA Nurses Community careHospital care
Mental Health
Total n = 32Advanced Practice Nurses n = 32
Hall et al, 200375 Interviews UK (England)
Nurses Community care
Range of Specialties
Total n = 21Community Nurses n = 21
Hall et al, 200640 Interviews and Surveys
UK (England)
Nurses Community care
Range of Specialties
Total n = 67Interviewed n = 23: District nurses n = 11, Health visitors n = 10, Practice nurses n = 2Surveys: NMP Leads n = 44
Hill et al, 201476 Interviews UK (Scotland)
Pharmacists Community care
Addiction Services
Total n = 97Service users n = 86, Pharmacist prescribers n = 5, Doctors n = 6
Hobson et al, Interviews UK Pharmacists, Community Range of Total n = 18
201049 (England) Nurses careHospital care
Specialties Service users n = 18
Jones et al, 201150
Interviews, non-participant observation and surveys
UK (England)
Nurses Hospital care Range of Specialties
Total: n = 196Interviewed n = 18: prescribers (profession not stated) n = 3, mentors/colleagues n = 7, Managers n = 8Structured non-participant observation of nurse prescribers n = 2, Doctors n = 2, consultations n = 52Surveys: Service users n = 122
Kelly et al, 201054
Surveys UK (England)
Nurses Community care
General Practice
Total n = 151Community Practice nurses n = 151
Lewis-Evans and Jester, 200458
Interviews UK (England)
Nurses Community care
Range of Specialties
Total n = 7Nurses n = 7
Luker et al, 199777
Interviews UK (England)
Nurses Community care
Range of Specialties
Total n = 256Service users n = 256; pre prescribing n = 157, post prescribing n = 148 (33.3% interviewed post were also interviewed pre-prescribing).
Maclure et al, 201341
Survey UK (Scotland)
Community-practitioner prescribers, Pharmacists,Nurses, Physiotherapists, Podiatrists, Optometrists
Community careHospital care
Range of Specialties
Total n = 1855Service users n = 1855
Makowsky et al, 201359
Interviews Canada Pharmacists Community care
Range of Specialties
Total n = 38Pharmacists n = 38
McCann et al, Surveys UK (NI) Pharmacists Community Range of Total n = 105
201142 careHospital care
Specialties Pharmacists n = 105
McCann et al, 201243
Interviews UK (NI) Pharmacists Community careHospital care
Range of Specialties
Total n = 35Pharmacists n = 11, Doctors n = 11, Other Stakeholders n = 13
Mulholland, 201465
Surveys UK Pharmacists Hospital care Paediatrics Total n = 45Pharmacists n = 45
Nolan et al, 200453
Surveys UK Nurses Community careHospital care
Mental Health
Total n = 51Nurses n = 51
Page et al, 200864
Interviews UK (England)
Nurses Hospital care Dementia Total n = 20Service users n = 13, Staff (non-prescribers) n = 7
Ross and Kettles, 201234
Surveys and focus groups
UK (Scotland)
Nurses Community careHospital care
Mental Health
Total n = 45Nurses n = 33, Focus group, Nurses n = 12
Ryan-Woolley et al 200829
Survey UK Nurses Community careHospital care
Oncology and Palliative care
Total n = 2252Nurses n = 2252
Ryan-Woolley et al 200728
Survey UK Nurses Community careHospital care
Oncology and Palliative care
Total n = 2252Nurses n = 2252
Scrafton et al, 201235
Interviews UK (England)
Nurses Hospital care Range of Specialties
Total n = 6Nurses n = 6
Shannon and Spence, 201178
Focus groups and Interviews
UK (Scotland)
Nurses Community careHospital care
Cardiology
Total n = 21Focus Groups: Doctors n = 21Interviews: Doctors n = 21,
Stenner et al, 200961
Interviews UK (England)
Nurses Community careHospital care
Dermatology
Total n = 18Doctors n = 12, Nurses (non-prescribers) n = 6
Stenner et al, 201046
Interviews UK (England)
Nurses Community care
Diabetes Total n = 31Nurse prescribers n = 10, Doctors n
Hospital care = 9, Admin staff n = 9, Nurses (non-prescribers) n = 3
Stenner and Courtenay, 2008a30
Interviews UK (England)
Nurses Community careHospital care
Pain Management
Total n = 26Nurse prescribers n = 26
Stenner and Courtenay, 2008b31
Interviews UK (England)
Nurses Community careHospital care
Pain Management
Total n = 26Nurse prescribers n = 26
Stenner et al 201160
Interviews UK (England)
Nurses Community care
Diabetes Total n = 41Service Users n = 41
Travers, 200544 Focus groups and interviews
UK (England)
Nurses Community care
Range of Specialties
Total n = 7Focus Groups: Nurses n = 7Interviews: Nurses n = 7,
While and Biggs, 200452
Surveys UK (England)
Nurses Community care
Range of Specialties
Total n = 91Community Nurses n = 91
Wix, 200779 Surveys UK (England)
Nurses Community careHospital care
Mental Health
Total n = 78Service users n = 78
Young, 200980 Interviews UK (Wales)
Nurses Community care
Range of Specialties
Total n = 5Community Nurses n = 5
Table 4Quality assessment using the Quality Assessment Tool for Studies with Diverse Designs tool, qualitative studies.
Ave
ry e
t al,
2007
Ben
nett
and
Jone
s, 20
08
Bra
dley
and
Nol
an, 2
007
Bra
dley
et a
l, 20
08
Car
ey e
t al,
2009
Car
ey e
t al,
2010
Cou
rtena
y an
d ca
rey,
200
9
Cou
rtena
y et
al,
2011
Cou
sins
and
Don
nell,
201
2
Dow
ner a
nd S
heph
erd,
201
0
Earle
et a
l, 20
11
Glo
d an
d M
anch
este
r, 20
00
Gui
rgui
s et a
l, 20
14
Hal
es, 2
002
Hal
l et a
l, 20
03
Hal
l et a
l, 20
06
Hill
et a
l, 20
14
Hob
son
et a
l, 20
10
Jone
s et a
l, 20
11
Kel
ly e
t al,
2010
Lew
is-E
vans
and
Jest
er,
2004
Luke
r et a
l, 19
97
Explicit theoretical framework 0 0 2 0 1 1 2 1 1 3 3 1 3 2 0 0 0 3 3 0 3 0Statement of aims/objectives in main body of report 2 3 1 2 3 3 3 2 2 3 3 2 2 1 1 2 0 2 3 3 3 0Clear description of research setting 3 2 2 2 2 1 3 3 3 1 3 3 3 2 2 2 1 3 3 2 3 2Evidence of sample size considered in terms of analysis 1 1 3 0 2 1 1 1 3 0 1 1 3 0 0 3 0 3 3 1 3 0Representative sample of target group of a reasonable
3 3 2 1 2 2 3 3 3 0 2 2 3 1 2 2 2 3 2 3 1 1
sizeDescription of procedure for data collection 1 3 3 3 2 2 3 3 2 2 3 2 3 2 2 3 3 2 3 1 2 1Rationale for choice of data collection tool(s) 2 3 0 0 0 0 3 2 1 3 0 0 3 0 0 0 0 0 2 0 3 0Detailed recruitment data 3 3 1 1 2 1 3 3 2 1 3 3 3 0 0 2 2 3 3 2 1 1Statistical assessment of reliability and validity of measurement tool(s) (quantitative only)
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A 1
N/A
N/A
N/A
N/A
N/A
N/A 1
N/A
N/A
N/A
Fit between stated research question and method of data collection (quantitative)
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A 3
N/A
N/A
N/A
N/A
N/A
N/A 1
N/A
N/A
N/A
Fit between stated research question and format and content of data collection tool eg,
0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 1 0 0
interview schedule (qualitative)Fit between research question and method of analysis 0 0 0 0 0 0 3 3 3 3 0 3 0 0 0 3 2 3 1 3 0 0Good justification for analytical method selected 0 1 2 0 1 3 1 0 0 3 2 0 3 0 0 3 0 3 3 0 3 0Assessment of reliability of analytical process (qualitative only) 0 0 0 0 3 3 3 2 3 0 3 0 3 0 0 3 1 2 3 0 3 0Evidence of user involvement in design 0 0 0 0 0 0 0 1 0 0 0 0 0 1 1 1 1 1 0 2 0 0Strengths and limitations critically discussed 3 0 3 0 2 2 2 1 1 1 3 3 3 0 1 3 2 3 3 0 3 0Total 18 19 19 9 20 19 30 25 24 20 26 27 32 9 9 27 14 31 35 17 28 5
Continued
Mac
lure
et a
l, 20
13
Mak
owsk
y et
al,
2013
McC
ann
et a
l, 20
11
McC
ann
et a
l, 20
12
Mul
holla
nd, 2
014
Nol
an e
t al,
2004
Page
et a
l, 20
08
Ros
s and
Ket
tles,
Rya
n-W
oolle
y et
al
2008
Rya
n-W
oolle
y et
al
Scra
fton
et a
l, 20
12
Shan
non
and
Spen
ce,
2011
Sten
ner e
t al,
2009
Sten
ner e
t al,
2010
Sten
ner a
nd
Cou
rtena
y, 2
008a
Sten
ner a
nd
Cou
rtena
y, 2
008b
Sten
ner e
t al 2
011
Trav
ers,
2005
Whi
le a
nd B
iggs
,
Wix
, 200
7
You
ng, 2
009
Explicit theoretical framework 1 3 0 2 0 0 2 1 0 0 3 2 2 1 0 2 2 0 0 0 3Statement of aims/objectives in main body of report 3 3 3 2 2 1 0 3 2 2 3 3 3 3 3 3 3 1 3 2 1Clear description of research setting 3 3 2 2 2 2 3 2 1 2 2 2 2 2 2 2 3 2 2 3 2Evidence of sample size considered in terms of analysis 0 3 2 2 2 1 0 1 1 3 3 0 3 1 2 3 0 0 1 0 0Representative sample of target group of a reasonable size 2 3 3 3 2 2 2 2 1 3 3 2 1 2 3 2 2 1 3 1 1Description of procedure for data collection 1 3 2 3 1 2 2 3 2 2 3 3 1 2 2 2 3 1 2 2 2Rationale for choice of data collection tool(s) 0 2 0 0 0 0 2 3 0 0 2 0 2 0 0 3 0 0 0 0 2Detailed recruitment data 0 3 3 3 2 3 1 3 2 3 2 2 1 2 1 2 3 2 3 1 2Statistical assessment of reliability and validity of measurement tool(s)
N/A
N/A
1 N/A
0 N/A
N/A
1 N/A
0 N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
0 0 N/A
(quantitative only)Fit between stated research question and method of data collection (quantitative)
N/A
N/A 0
N/A 0
N/A
N/A 0
N/A 0
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A 0 0
N/A
Fit between stated research question and format and content of data collection tool e.g. interview schedule (qualitative) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0Fit between research question and method of analysis 3 0 0 3 0 0 0 3 2 2 3 3 0 3 3 3 2 0 0 0 0Good justification for analytical method selected 2 3 1 1 0 0 1 3 0 0 2 2 1 0 1 1 0 1 1 0 1Assessment of reliability of analytical process (qualitative only) 0 3 0 3 0 2 3 3 2 0 1 2 3 3 3 3 3 0 0 0 1Evidence of user involvement in design 2 0 2 0 0 2 0 3 1 0 0 2 0 0 0 0 0 2 2 0 1Strengths and limitations critically discussed 1 3 1 1 0 2 3 3 1 2 2 1 3 2 2 2 2 0 3 1 3Total 18 32 20 25 11 17 19 34 15 19 29 24 22 21 22 28 23 10 20 10 19
Table 7Included quantitative studies and characteristics.
Study Design Country NMP profession Healthcare setting
Healthcare specialty
Participants
Courtenay and Carey, 200866
Survey: Postal questionnaire 2006
UK Nurses Community care,Hospital care
Range of Specialties
Total n = 1992Nurses n = 1992
Courtenay et al, 201271
Survey: Online questionnaire2010 to 2011
UK Community-practitioner prescribers, Pharmacists,Nurses, Physiotherapists, Podiatrists, Optometrists
Community care,Hospital care
Range of Specialties
Total n = 883Nurses n = 793, Managers n = 33, Pharmacists n = 36, Allied health and Optometrists n = 9, not disclosed n = 12
Farrell et al, 201167
Survey: Online or postal questionnaireCollection year NR
UK Nurses Community care,Hospital care
Oncology Total n = 103Nurses n = 103
Gumber et al, 201270
Survey: Postal questionnaire 2010
UK Nurses, Pharmacists Community care,Hospital care
Range of Specialties
Total n = 20Nurses n = 18, Pharmacists n = 2
Hutchison et al, 201263
Survey: Online questionnaire
Canada Pharmacists Hospital care Range of Specialties
Total n = 342Pharmacists n = 342
2010
Kaplan and Brown, 200468
Survey: Postal questionnaire2001
USA Nurses Community care,Hospital care
Range of Specialties
Total n = 1241Nurses n = 1241
Larsen, 200469 Survey: Postal questionnaire
UK Nurses Community care,Hospital care
Emergency/Urgent care
Total n = 192Managers n = 192
Table 8Quality assessment using the Quality Assessment Tool for Studies with Diverse Designs tool, quantitative studies.23
Domain Study reference number
Courtenay and Carey,
200866
Courtenay et al,
201271
Farrell et al, 201167
Gumber et al, 201270
Hutchison et al,
201263
Kaplan and Brown, 200464
Larsen, 200469
Explicit theoretical framework 1 0 0 0 0 0 0Statement of aims/objectives in main body of report 3 3 2 3 1 3 3Clear description of research setting 2 3 2 3 3 3 2Evidence of sample size considered in terms of analysis 3 1 2 1 1 1 0Representative sample of target group of a reasonable size 3 3 3 2 3 3 1Description of procedure for data collection 3 3 2 1 3 3 2Rationale for choice of data collection tool(s) 0 1 1 0 0 1 0Detailed recruitment data 3 3 3 1 3 3 2Statistical assessment of reliability and validity of measurement tool(s) (quantitative only) 0 0 0 0 0 0 0Fit between stated research question and method of data collection (quantitative) 0 0 0 0 0 0 0Fit between stated research question and format and content of data collection tool eg, interview schedule (qualitative) N/A N/A N/A N/A N/A N/A N/AFit between research question and method of analysis 0 0 0 0 0 0 0Good justification for analytical method selected 0 2 0 0 0 0 0Assessment of reliability of analytical N/A N/A N/A N/A N/A N/A N/A
process (qualitative only)Evidence of user involvement in design 1 1 2 0 2 2 2Strengths and limitations critically discussed 2 2 0 3 3 1 2Total
21 22 17 14 19 20 14