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Feb 9 2010 UNCLASSIFIED Vision and Mission Vision: to provide relevant, timely, actionable, and comprehensive health surveillance information and support to the Armed Forces for military and military-associated populations Mission: to promote, maintain, or enhance the health of military and military-associated populations Acquire, analyze and interpret, recommend, and disseminate information Develop, refine and improve standardized surveillance methods Serve as focal point for sharing health surveillance products, expertise and information Delineate roles, responsibilities, and mutually supporting relationships among the Armed Forces health surveillance activities Armed Forces Health Surveillance Center

Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

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Page 1: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

Feb 9 2010 UNCLASSIFIED

Vision and Mission

• Vision: to provide relevant, timely, actionable, and comprehensive health surveillance information and support to the Armed Forces for military and military-associated populations

• Mission: to promote, maintain, or enhance the health of military and military-associated populations– Acquire, analyze and interpret, recommend, and

disseminate information– Develop, refine and improve standardized surveillance

methods– Serve as focal point for sharing health surveillance

products, expertise and information– Delineate roles, responsibilities, and mutually supporting

relationships among the Armed Forces health surveillance activities

Armed Forces Health Surveillance Center

Page 2: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

Feb 3 2010 UNCLASSIFIED

AFHSC Operating Structure

DIRECTOR Armed Forces Health Surveillance Center

Dep Dir, AFHSC/Director, GEIS

DoD Serum Repository

AFHSC HQ Support

Science Advisor Executive Officer Resource Mgr Chief, Information Officer

Chief, Data and AnalysisChief, Communications, Standards,

& TrainingChief, GEIS Operations

Data Management

Epidemiology/Analysis Surveillance Operations

& CommunicationsSurveillance Standards

& Training

AI/PISurveillance

GEISCore

LiaisonsUSPHS

DHSWHO

Page 3: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

Feb 9 2010 UNCLASSIFIED

• Vision: Successfully develop, implement, support, and evaluate an integrated global emerging infectious disease surveillance and response system that supports the AFHSC and promotes preparedness in US Forces, the Military Health System and the Global Public Health community.

• Mission: Contribute to Force Health Protection and Global Public Health by centrally coordinating a global system of partners that conduct emerging infectious disease surveillance and response; training and capacity building; research, innovation and integration; and assessment of value added in a timely, efficient, comprehensive and communicative manner.

“Partnering in the Fight against Emerging Infections”

Division of GEIS Operations(DOD GEIS)

Page 4: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

Strategic Goals and Priority Pillars

AR

D

GI

DR

O

ST

I

RI = Respiratory Infection

GI = Gastrointestinal Infection

FVBI = Febrile and Vector-borne Infection

AR = Antimicrobial Resistance

STI = Sexually Transmitted Infection

AFHSC/DOD-GEIS

Assessment and Communication of Value AddedResearch, Innovation and Integration

Surveillance and ResponseTraining and Capacity Building

RI

GI

AR

ST

I

FV

BI

Force Health Protection

Feb 9 2010 UNCLASSIFIED

Page 5: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

AFHSC Global Network

DOD’s Unique Assets – Overseas Presence with OCONUS Labs

Peru

Kenya

Egypt

Thailand

Indonesia

Navy Hub

Air Force Hub

WRAIR, NMRC

AFIP

Germany KoreaKorea

Feb 9 2010UNCLASSIFIED

Page 6: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

Predictive Surveillance Benefit

WHO World Health Report 2007

Feb 9 2010 UNCLASSIFIED

Page 7: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

Predictive Surveillance Model

Feb 9 2010 UNCLASSIFIED 8

b

Eco-climate trend and condition characterization and surveillance

Insect vector characterization and pathogen transmission surveillance

Animal host/reservoir characterization and pathogen transmission surveillance

Human conditions/activities characterization for association with disease outbreaks; Human case surveillance

Eco-climate anomaly critical-point detection and analysis

Vector signal of critical-point detection for pathogen transmission

Animal signal of critical-point detection for pathogen transmission

Community or clinic signal of critical-point detection of human infection

Advisory on emerging eco-climate conditions conducive to outbreaks

Alert on vector transmission threat that promotes targeted, pre-emptive vector and/or animal interventions

Prediction of human risk based on animal disease and transmission threat to promote targeted pre-emptive public health interventions

Early alert of human disease outbreak, for timely control interventions

Info

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Info

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Info

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Page 8: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

Predictive Surveillance TimelineEven

tA

ctio

n

Hu

man

illn

ess

Hu

man

ou

tbre

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an

d r

esp

on

se

Hu

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Con

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Clim

ate

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em

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ts

Eco

/clim

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even

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an

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Vect

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An

imal/re

serv

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ill

ness

Com

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Retr

osp

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ata

Th

reat

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ion

Eco

/clim

ate

an

aly

sis

Ris

k ale

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Ris

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ory

An

imal/re

serv

oir

case

rep

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Weath

er/

vect

or

surv

eill

an

ce

Weeks/Months

Feb 9 2010 UNCLASSIFIED

Page 9: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

Continuous Remote SensingEco/Climate Anomalies

A Anyamba, NASAFeb 9 2010 UNCLASSIFIED

Page 10: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

Ground Truthing

J Small, NASA

UnclassifiedFeb 9 2010

Page 11: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

Ground Truthing

T Klein, J Grieco, A Anyamba,K Linthicum

USAMRU-K Mosquito samplings sites

Feb 9 2010 UNCLASSIFIED

Page 12: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

Country / Region

Alert to Outbreak (months)

2008South Africa

2 – 3

2007: Sudan 4 - 5

2006:East Africa

4

Predictive Surveillance RVF Outbreaks 2006-2008

In pressA Anyamba, NASAFeb 9 2010UNCLASSIFIED

Page 13: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

Refining the RVF Model

Feb 9 2010 14UNCLASSIFIED

Anyamba et al, PNAS, 106(3)955 (2009).

Climatic Factors: heavy and widespread

rainfall

Coastal Flood Plain

Aedes species followedby Culex in large number

Culex species –Important secondaryvector in RVF

Page 14: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

Mosquito Map

TaxonomicTaxonomic

++Point occurrencePoint occurrence

++EnvironmentalEnvironmental

Mosquito Mosquito Distribution Distribution ModelsModels

Foley, et al. J Med Ento, 46 (3) 2009

Feb 9 2010 UNCLASSIFIED

Page 15: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

Animal Reservoir

Feb 9 2010 UNCLASSIFIED

Page 16: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

Human Disease Surveillance

Data management

OUTBREAK

RESPONSE

Absenteeism

Radiology

DiagnosticLabs

Poison Control

Prescriptions

Physician OfficeVisits

NurseCall

Center

Over theCounterSales

Data sources detection reporting

S Lewis, JHU/APL

Feb 9 2010 UNCLASSIFIED

Page 17: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

AFHSC Template

Feb 9 2010 UNCLASSIFIED 1

Page 18: Armed Forces Health Surveillance Center Predictive Surveillance Program A Multidisciplinary Approach for the Early Detection and Response to Disease Outbreaks

 

 

 

Feb 9 2010 UNCLASSIFIED 1

NASA-GSFC: A Anyamba, J Small, J Pinzon, CJ Tucker, E Pak

USDA: K Linthicum

WRBU: D Foley, P Rueda, R Wilkerson

USUHS: P Masuoka, J Grieco, N Achee

USAMRU-K: J Cook, D Schnabel KEMRI: R Sang

AFRIMS: J Richardson, J Pavlin

65th Medical Brigade: T Klein

JHU/APL: S Lewis, B Feighner, A Buczac

Acknowledgements