Hauer-Jensen

CURRICULUM VITAE (April 2020)

Martin Hauer-Jensen, MD, PhD, FACS

GENERAL INFORMATION

Born: April 4, 1953, Namsos, Norway

Citizenship: United States, Denmark (dual)

Family status: Married, one child

Wife: Cynthia S. Ross, MD (specialty: radiation oncology)

Daughter: Miriam (born 12/13/1998)

Work address: Division of Radiation Health,

University of Arkansas for Medical Sciences,

4301 West Markham, Mail Slot 522-10,

Little Rock, AR 72205.

Tel: (501) 686-7912

Fax: (501) 421-0022

E-mail: MHJENSEN@UAMS.EDU

Home address: 3229 Foxcroft Road,

Little Rock, AR 72227

Tel: (501) 993-2593

PRESENT APPOINTMENTS

University of Arkansas for Medical Sciences, Little Rock, AR

Professor, Department of Pharmaceutical Sciences, College of Pharmacy

Professor, Department of Surgery, College of Medicine

Professor, Department of Pathology, College of Medicine

Associate Dean for Research, College of Pharmacy

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EDUCATION, DEGREES, CERTIFICATIONS

Education and Examinations

9/1/1971-6/20/1977 Medical School, University of Oslo, Oslo, Norway

1990 Foreign Medical Graduate Examination in the Medical Sciences (FMGEMS)

Degrees

Jun 20, 1977 M.D, University of Oslo, Oslo, Norway

Jan 22, 1988 Ph.D., University of Oslo, (Field: Radiation Biology).

Certifications and Licensure

Jan 10, 1979 Norwegian Medical Board license – valid until 4/4/2028 (Health Personnel Registration Number: 2095785)

Feb 23, 1988 Board certification in General Surgery (Norway)

Jun 15, 1990 ECFMG certification (# 444-047-5)

Sep 19, 1991 Arkansas State Medical Board license (# C-8156) (National Provider Identifier 1902811839)

Oct 26, 1995 Fellow, American College of Surgeons (FACS)

POSTGRADUATE TRAINING

7/1977 -12/1978 Intern, Buskerud Central Hospital, Drammen, Norway and Sande, Vestfold, Norway

1/1979 - 4/1982 Resident, Department of Surgery, Deacon Hospital, Oslo, Norway

5/1982 - 9/1985 Resident, Department of Surgery, University of Oslo (Ullevaal Hospital), Oslo, Norway

10/1985 - 7/1987 Postdoctoral Associate, Radiation Research Laboratory, University of Iowa, Iowa City, IA

8/1987 - 1/1989 Subspecialty Resident, Gastrointestinal Surgery, Department of Surgery, University of Oslo, Oslo, Norway

10/1990 - 6/1991 Chief Resident, Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR

POSITIONS HELD

2/1989 - 8/1990 Staff Surgeon, Department of Surgical Oncology, The Norwegian Radium Hospital, Oslo, Norway

2/1989 - 8/1990 Director, Clinical Trials Office, The Norwegian Radium Hospital, Oslo, Norway

7/1991 - 6/1992 Instructor, Department of Surgery, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR

7/1992 - 6/1995 Assistant Professor, Department of Surgery, UAMS

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Hauer-Jensen

12/1992 - 6/1995 Assistant Professor, Department of Pathology, UAMS

7/1993 - 6/1999 Associate Director of Clinical Research, Arkansas Cancer Research Center (ACRC), Little Rock, AR

7/1995 - 6/1999 Associate Professor (with tenure), Department of Surgery, UAMS

7/1995 - 6/1999 Associate Professor (with tenure), Department of Pathology, UAMS

7/1999 - 8/2001 Director of Clinical Research, ACRC

3/1992 - 3/2017 Staff Surgeon, Surgical Service, Central Arkansas Veterans Healthcare System (CAVHS), Little Rock, AR

9/2008 -12/2019 Director, Division of Radiation Health, UAMS

7/1999 - present Professor (with tenure), Department of Surgery, UAMS

7/1999 - present Professor (with tenure), Department of Pathology, UAMS

7/2008 - present Professor (with tenure), Department of Pharmaceutical Sciences, UAMS

7/2008 - present Associate Dean for Research, College of Pharmacy, UAMS

HONORS AND AWARDS

Numerous invited seminars, lectureships, and visiting professorships across the US, Europe, Asia, and Australia.

Oslo Surgical Society, A. Malthe Research Award 1983.

Oslo Surgical Society, A. Malthe Travel Award 1984.

Norwegian Cancer Society, Postdoctoral Fellowship 1985-1987.

American Cancer Society, Clinical Oncology Career Development Award 1994-1997.

Best Doctors in America 1996-2002, 2005-2006.

American Cancer Society, Legends Award for Cancer Research, 2004.

National Institutes of Health/National Cancer Institute, MERIT Award, 2008.

Rho Chi Pharmaceutical Honor Society, 2009

J. Thomas May Distinguished Endowed Chair in Oncology, 2016

RESEARCH INTERESTS

Clinical: Oncology (radiation, surgical, and medical); surgery; gastroenterology; research methodology; clinical trials design; biostatistics

Basic: Radiation biology of normal tissues; translational preclinical research; gastrointestinal pathophysiology; inflammation; extracellular matrix biology; endothelial and cardiovascular biology; animal model development

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EXTERNAL PEER REVIEW SERVICE

Reviewer of scientific manuscripts for journals (in alphabetic order):

Acta Chirurgica Scandinavica; Acta Oncologica; American Journal of Pathology; British Journal of Radiology; Cancer; Cancer Research; Current Gene Therapy; Digestion; Digestive Diseases and Sciences; DNA Sequence; European Journal of Surgery; Free Radical Biology and Medicine; Gastroenterology; Gene Therapy; Hernia; International Journal of Cancer; International Journal of Hyperthermia; International Journal of Radiation Biology; International Journal of Radiation Oncology Biology Physics; Journal of Clinical Oncology; Journal of Histochemistry and Cytochemistry; Journal of Pharmacology and Experimental Therapeutics; Journal of Supportive Oncology; Journal of Thrombosis and Haemostasis; Life Sciences in Space Research; PLoS One; Radiation Physics and Chemistry; Radiation Research; Radiotherapy and Oncology; Scandinavian Journal of Gastroenterology; Scanning Microscopy; Science

Service on editorial boards of scientific journals:

2008 – 2013 Radiation Research, editorial board

2005 – present In Vivo, editorial board

2010 – present ISRN Gastroenterology, editorial board

2011 – present Frontiers in Radiation Oncology, editorial board

2013 – present Journal of Pharmacology and Pharmaceutical Science (JPPS), editorial board

2013 – present Radiation Research, senior editor

2014 – present World Journal of Gastroenterology, editorial board

Memberships of national and international study sections and review panels:

1990 - 2002 Ad hoc reviewer, US Veterans Administration, Dutch Cancer Society, National Cancer Institute of Canada

2001 - 2002 Ad hoc study section member, US Veterans Administration, Oncology Merit Review Subcommittee

2002 - 2005 Member, NIH, Radiation Therapeutics and Biology (RTB) study section

2003 - 2004 Ad hoc reviewer, US Army Medical Research Program

2003 - 2011 External advisor, Armed Forces Radiobiology Research Institute (AFRRI)

2004 Session Chair, NIH/NIAID, Blue Ribbon Panel on Biodefense Research

2004 Member, DHS/NIAID, Bioshield Initiative Review Panel

2004 - 2011 Member, DHHS, Working Group for Development of the National Medical Response Plan for Radiological/Nuclear Terrorism

2005 External reviewer, U.S. Department of State, Science Center Program

2005 - 2007 Chair, NIH, Radiation Therapeutics and Biology (RTB) study section

2008 Member, Biomedical Advanced Research and Development Authority (BARDA) Review Panel

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2009 Member, NIH Distinguished Editorial Panel

2009 - 2012 Panelist, Consultation on Harmonization of Medical Countermeasures for Radiation Emergencies, World Health Organization (WHO), Geneva, Switzerland

2013 - 2015 Member, Panel of Editors, Transformative Research Award (TRA), NIH

2014 Chair, CDMRP PRMP CTA-2 Review Panel

1995 - present Various roles as reviewer for NIH: study section member/chair, site visit team member, special emphasis panel member/chair, external reviewer (Oncological Sciences IRG; Digestive Sciences IRG)

RESEARCH SUPPORT

Intramural and Industry-Sponsored Research Awards as PI:

Late Radiation Enteropathy. (Role: Principal Investigator. American Cancer Society Institutional Pilot Study Grant. University of Arkansas for Medical Sciences Pilot Study. 1991-1992).

Role of Fibrogenic Cytokines and Growth Factors in the Development of Late Radiation

Enteropathy. (Role: Principal Investigator. Pilot Study Grant. University of Arkansas for Medical Sciences. 1993).

Tension Free Inguinal Hernia Repairs. (Role: Principal Investigator. Bard Vascular Corporation. 1993-1995).

Octreotide (Sandostatin®) as a Protectant Against Intestinal Radiation Toxicity. (Role: Principal Investigator. Sandoz (Novartis). 1996-1997).

OR-1384 as a Protectant Against Intestinal Radiation Toxicity. (Role: Principal Investigator. Orion Pharma. 1996-1998).

Modulation of radiation-induced fibrosis. (Role: Principal Investigator. Biogen Corporation. 1999-2000).

Mast cells and hyperhomocysteinemia-induced cardiac remodeling. (Role: Co-investigator, 5% effort [PI: Jacob Joseph, MD]. VA Biomedical Research Foundation. 1/1/2003-12/31/2003).

Proteasomal regulation of thrombomodulin. (Role: Co-investigator, 10% effort [PI: Usha Ponnappan, PhD]. VA Biomedical Research Foundation. 1/1/2003-12/31/2003).

Vascular disease and radiation fibrosis. (Role: Principal Investigator, 10% effort). UAMS-ABI Tobacco Settlement Fund. 1/1/2003-6/30/2005).

Natrional Peer Reviewed Research Awards ( indicates active grant):

Late Radiation Enteropathy. (Role: Principal Investigator. American Cancer Society Research Grant, DHP-78, 1/1/1993-12/31/1996, $ 233,000 direct).

Clinical Oncology Career Development Award. (American Cancer Society, #94-32. 7/1/1994-6/30/1997. $ 90,000 direct).

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New Methods to Monitor and Prevent Intestinal Radiation Injury. (Role: Principal Investigator. Arkansas Science & Technology Authority, #97-A-06. 10/1/1996-9/30/1998. $ 39,400 direct).

Late Radiation Enteropathy. (Role: Principal Investigator. American Cancer Society Research Grant (competing continuation of DHP-78), RPG-93-008-04-EDT, 1/1/1997-12/31/1999, $ 157,000 direct).

Molecular and Cellular Mechanisms of Intestinal Radiation Injury. (Role: Principal Investigator. Department of Veterans Affairs Merit Review Grant. 5/1/1997-4/30/2001. $ 393,000 direct).

Endothelial Dysfunction in Pathogenesis of Intestinal Radiation Toxicity. (Role: Principal Investigator. Department of Veterans Affairs Merit Review Grant. 10/1/1999-9/30/2004. $ 755,200 direct).

Molecular Pathogenesis of Radiation Enteropathty. (Role: Principal Investigator. NIH/NCI, CA71382, 5/1/1997-8/31/2001. $ 543,975 direct).

Institutional Research Grant. (Role: Principal Investigator. American Cancer Society, IRG-91-021-09, 7/1/1999-6/30/2002. $ 180,000 direct).

Cardiac Effects of Hyperhomocysteinemia. (Role: Co-Investigator, 5% effort [PI: Jacob Joseph, MD] AHA, 0360003Z, 1/1/2003-12/31/2004. $ 121,000 direct).

Experimental Pathology Shared Resource Laboratory. (Role: Co-Investigator, 10% effort [PI: Laura W. Lamps, MD]. NIH/NCI, R24 CA82899, 7/15/1999-6/30/2005. $ 725,000 direct).

Endothelial Dysfunction in Intestinal Radiation Toxicity. (Role: Principal Investigator, 30% effort. NIH/NCI, CA83719, 7/1/2000-6/30/2005, $ 950,630 direct).

Mast cells and radiation induced heart disease. (Role: Primary Sponsor, 10% effort [Fellow: Marjan Boerma], AHA, 0425933Z, 7/1/2004-6/30/2006. $ 81,000 direct).

Molecular Pathogenesis of Radiation Enteropathy. (Role: Principal Investigator, 30% effort. NIH/NCI, R01 CA71382, 9/1/2001-8/31/2008. $ 933,750 direct).

Somatostatin Analogues as Countermeasures against Intestinal Radiation Injury. (Role: Program and Project Leader, 15% effort. NIH/NIAID U19 AI67798 (050003), 8/31/2005-7/31/2010, $ 758,230 direct).

Statins as Radiation Countermeasure. (Role: Principal Investigator, 30% effort [VA effort only]. Department of Veterans Affairs Merit Review Grant. 10/1/2005-9/30/2008. $ 373,800 direct).

Radiation Prophylaxis by Gamma-Tocotrienol. (Role: Principal Investigator, 10% effort. Defense Threat Reduction Agency, HDTRA1-07-C-0028, 1/26/2007-1/25/2010. $ 768,096 direct).

Transforming Growth Factor Beta and Radiation-induced heart disease. (Role: Primary Mentor, <5% effort. Lance Armstrong Foundation Young Investigator Award to Dr. Marjan Boerma. 1/1/2007-12/31/2009. $ 100,000 direct).

Combined Effect of Gamma-Tocotrienol and Pentoxifylline on Radiation Protection: Efficacy

and Molecular Mechanisms. (Role: Co-Principal Investigator, 10% effort. Defense Threat Reduction Agency, HU00001-07-1-0009 (164552), 8/15/2007-11/30/2010. $ 834,904 direct).

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Oral Interleukin 11 as a Countermeasure against Radiation Injury to Gut (PI: Burnett, Role: Co-Investigator, 5% effort. NIH/NIAID RC1 AI78515, 9/1/2007-2/28/2011. $ 451,969 direct).

Synergistic radioprotection of gastrointestinal tract by gamma-tocotrienol and statins: efficacy

and mechanisms. (Role: Co-Principal Investigator, 10% effort. Defense Threat Reduction Agency, HU0001-09-1-0005 (671558), 1/25/2010-9/30/2011. $753,792 direct).

Advanced Drug Development of Gamma-Tocotrienol as a Radiation Countermeasure in Rhesus

Macaque Non-Human Primates. (Role: Co-Principal Investigator, 10% effort. Defense Threat Reduction Agency, HU0001-10-1-0004 (710014), 1/25/2010-2/13/2012. $194,400 direct).

Endothelial Dysfunction in Intestinal Radiation Toxicity. (Role: Principal Investigator, 20% effort. NIH/NCI, R01 CA83719, 7/1/2005-4/30/2012, $ 1,062,500 direct).

Advanced Development of SOM230 as a Radiation Mitigator. Role: Principal Investigator. 30% effort. Biomedical Advanced Research and Development Authority (BARDA) HHSO100201100045C, 9/26/2011-9/25/2013, $ 4,587,597 total.

Advanced Development of SOM230 as a Radiation Mitigator. Role: Principal Investigator. 20% effort. Biomedical Advanced Research and Development Authority (BARDA) & Department of Defense (DoD) HHSO100201100045C, 9/26/2013-9/25/2014, $ 1,242,259 total.

Arkansas Center for Clinical and Translational Research (PI: Lowery, Role: Collaborator, 7% effort. NIH/ NCRR, UL1 RR029884, 7/1/2009-3/31/2014. $ 13,891,380 direct).

Individualizing Cancer Predictions via Selective Voting in Convex-Hull Ensembles (PI: Kodell, Role: Co-Investigator, 3% effort. NIH/ NCI, R01 CA152667, 7/1/2010-6/30/2014. $ 622,500 direct).

Somatostatin Analogs as Countermeasures against Intestinal Radiation Injury. Competing continuation. Role: Program and Project Leader, 20% effort. NIH/NIAID U19 AI67798-066745, 8/1/2010-7/31/2015, $ 898,410 direct.

The Role of NADPH oxidase(s) in Therapy-Related Myelodysplastic Syndrome and Acute

Myelogenous Leukemia (t-MDS/AML). Role: Co-Principal Investigator, 5% effort. Edward P. Evans Foundation, 4/1/2012-3/31/2015, $ 1,000,000 direct.

Molecular Pathogenesis of Radiation Enteropathy. (Role: Principal Investigator, 30% effort. NIH/NCI, R37 (MERIT Award) CA71382, 4/1/2008-3/31/2016. $ 1,150,694 direct).

Radiation-Induced Heart Disease: Mechanisms and Interventions (PI: Boerma, Role: Co-Investigator, 5% effort. NIH/ NCI, R01 CA148679, 7/1/2010-4/30/2016. $ 1,037,500 direct).

Advanced Development of SOM230 as a Radiation Mitigator. Role: Principal Investigator. 30% effort. Biomedical Advanced Research and Development Authority (BARDA) HHSO100201100045C, 9/26/2013-6/30/2017, $ 7,500,000 total.

Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation. Role: Associate Center Director. 15% effort. National Space Biomedical Research Institute (NSBRI) RE03701, 06/01/2014-5/31/2017. $ 6,600,000 total.

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Algorithms to generate designs of potency experiments that use far fewer animals. (PI: Landes, Role: Co-Investigator), 5% effort. NIH/NCI, R21 CA184756, 9/1/2015-8/31/2017. $ 356,483 total.

Role of C/EBP Delta in IR-Induced Sepsis. (PI: Pawar, Role: Co-Investigator), 5% effort. CDMRP/US Army Medical Research and Materiel Command W81XWH-15-1-0489, 9/1/2015-8/31/2019. $ 1,438,082 total.

Center for Studies of Host Response to Cancer Therapy. Role: Principal Investigator. 30% effort. NIH/NIGMS P20 GM109005, 6/24/2015-3/31/2021. $ 10,581,280 total.

Advanced Development of Gamma-Tocotrienol as a Radiation Countermeasure. (PI: Singh, UAMS PI: Hauer-Jensen) 20% effort. USAMRAA W81XWH-15-C-0117, 9/21/2015-9/20/2020. $ 7,777,146 total.

Role of Senescent Cells in Radiation-induced Pulmonary Fibrosis. (PI: Zhou, Role: Co-Investigator) 4.5% effort. NIH/NCI R01 CA211963, 7/1/2017-6/30/2022. $ 1,731,868 total.

The Protein C Pathway in Mitigation of Radiation-induced Endothelial and Vascular

Dysfunction. (PI: Boerma, Role: Co-Investigator) 5% effort. NIH/NIAID U01 AI133561, 7/1/2017-6/30/2022. $ 2,977,280 total.

Evaluation of IPW-5371, a TGFbRI kinase inhibitor, dosed as a single agent or in

combination with G-CSF, as a medical countermeasure against the delayed effects of total

body irradiation in mice. (PI: Hart, Role: Co-Investigator) 5% effort. NIH/NIAID R43 AI38868, 4/1/2018-3/31/2020. $ 641,898 total.

INDUSTRY RELATIONSHIPS

Selected past collaborations with pharmaceutical and biotechnology companies:

Orion (orazipone); Monsanto-Searle (SOD mimetics); Johnson&Johnson (PAR1 antagonists); Sanofi (heparins, clopidogrel); Biotech-Pharmacon (beta-glucan); American Diagnostica (thrombomodulin); Surface Logix (ROCK inhibitors); Biogen-Idec (integrins)

Selected ongoing collaborations with pharmaceutical and biotechnology companies:

Paion (solulin); Schering-Plough (PAR1 antagonists); Novartis (somatostatin analogs); Yasoo Health (gamma-tocotrienol); Biogen-Idec (TGFβ receptor inhibitors); Sanofi (substance P antagonists)

2007-2011 Member, Nuclear and Radiological Countermeasure Advisory Board, Osiris Therapeutics

2008-2012 Member, Advisory Board, Sirtex Medical

2013-2018 Member, External Advisory Board, Soligenix, Inc.

2014-2019 Member, External Advisory Board, Altasciences (formerly SNBL USA)

ADMINISTRATIVE, SCIENTIFIC, AND PROFESSIONAL LEADERSHIP EXPERIENCE

1989-1990 Director, Clinical Trials Office, The Norwegian Radium Hospital, Oslo, Norway

1993-1999 Associate Director of Clinical Research, Arkansas Cancer Research Center (ACRC), University of Arkanas for Medical Sciences (UAMS), Little Rock, AR

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1999-2001 Director of Clinical Research, ACRC

1992-2004 Cancer Liaison Physician, American College of Surgeons Commission on Cancer, Central Arkansas Veterans Healthcare System, Little Rock, AR

2003-2008 Program Leader, Cancer Survivorship Program, ACRC

2004-2008 Chairman, Arkansas Cancer Coalition, Cancer Survivorship Work Group

2013-2016 VP-elect → Vice President → President, Radiation Research Society

2008-2019 Director, Division of Radiation Health, UAMS

2008-2020 Program Co-Leader, DNA Damage and Host Response Program, Winthrop P. Rockefeller Cancer Institute (WPRCI)

1991-present Member and/or chair of various local, national, and international committees and advisory boards related to clinical research, basic research, research compliance, education, research infrastructure, and/or technology transfer (see details under the heading Committee Service, below)

2008-present Associate Dean for Research, UAMS College of Pharmacy

FUNDRAISING TRAINING AND EXPERIENCE

7/2004 Course in fundraising principles and techniques, The Fund Raising School, Center on Philanthropy at Indiana University

COMMITTEE SERVICE

Local Committees:

UAMS College of Medicine, COBRE Center for Translational Pediatric Research, Internal Advisory Committee (2016-present)

UAMS College of Pharmacy, Department of Pharmaceutical Sciences Executive Committee – Member (2014-present).

UAMS College of Pharmacy Administrative Council – Member (2008-present).

UAMS College of Medicine, SPaT Training Grant, Executive Committee (2016-2019)

UAMS College of Pharmacy Development Committee – Member (2011-2018).

UAMS Cardiovascular Center Steering Committee – Member (2010-2015).

UAMS Data Warehouse Governance Committee – Member (2011-2015).

UAMS Institutional Animal Care and Use Committee - Member (1991-2015).

VA Research & Development Committee – Member (1995-2005) – Chair (2002-2005) – Vice Chair (2008-2015).

VA Cancer Committee - Member (1992-2011) - Chairman (1995-2011).

VA Clinical Measures and Outcomes Committee – Member (2005-2011).

UAMS College of Medicine Research Council - Member (1992-2006).

UAMS MD/PhD Committee – Member (2000-2009)

UAMS Emergency Management Committee – Member (2004-2010)

South Central VA Health Care Network (VISN 16) Radiation Therapy Program Review Committee – Consultant (2003-2005)

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UAMS Department of Surgery Executive Committee – Member (1998-2002).

American Cancer Society Institutional Grant Review Panel (UAMS) - Member (1997-1998) – Chairman (1999-2002).

Arkansas Children’s Nutrition Center, Scientific Advisory Committee - Member (2000 – 2004)

ACRC Scientific Steering Committee – Member (1999-2002).

ACRC Space Committee – Member (1999-2001).

ACRC Cabinet - Member (1994-2001).

ACRC Protocol Review and Monitoring Committee - Chairman (1994-2001).

UAMS Media Services Advisory Committee – Member 1999-2001

Center of Study of Opportunistic Infections Advisory Committee - Member (1996-2001).

Center for Outcomes Research and Evaluation Steering Committee - Member (1994-1999).

General Clinical Research Center (GCRC) Advisory Committee – Member (1998-2000).

Clinical Research Subcommittee, Faculty Group Practice Executive Committee (GPEC) – Member (1996-1998).

UAMS Department of Surgery Academic Affairs Committee - Member (1994-1998).

UAMS Human Research Advisory Committee (IRB) - Member (1993-1995).

UAMS Clinical Trials Program Steering Committee - Member (1993-1995), Chairman (1995-1996).

UAMS Student Promotion Committee - Member (1993-1996).

VA Medical Records Committee - Member (1992-1993).

External Advisory Committees:

University of Iowa, P01, External Advisory Committee, Member (2019-present).

University of Kentucky, COBRE, External Advisory Committee, Member (2017-present).

Malaysian Palm Oil Board, Program Advisory Committee, Member (2017-2019).

Altasciences (formerly SNBL USA), External Advisory Board, Member (2014-2019).

NASA CNS NSCOR External Advisory Board, Chair (2009-2019).

Duke University, Center for Medical Countermeasures against Radiation (RadCCORE), External Advisory Committee, Member (2016-2018).

Duke University, Center for Medical Countermeasures against Radiation (RadCCORE), Steering Committee Member (2004-2015)

University of Pennsylvania, Specialized Center of Research in Hyperbaric Oxygen Therapy (2001-2005).

Armed Forces Radiobiology Research Institute, External Advisory Board (2003-2008).

National Committees:

Radiation Research Society – Journal Editorial Committee 2008-present

Radiation Research Society – Vice President Elect, Vice President, President 2013-2016

Radiation Research Society – Program Committee 2007-2009, 2014-1015 (chair)

Radiation Research Society – Government Liaison Committee 2007-2016

National Council on Radiation Protection & Measurement – Councilor 2010-2016

Radiation Research Society – Councilor (Medicine) 2011-2013

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American Society for Therapeutic Radiology and Oncology – member, Radiobiology Practice Exam and Study Guide Subcommittee of the Science Council, 2012-2015

American Society of Therapeutic Radiology and Oncology- Radiobiology Practice Exam and Study Guide Subcommittee 2008-2013

American Society of Therapeutic Radiology and Oncology- Radiobiology Practice Exam and Study Guide Subcommittee 2008-2013

American Radium Society – Program Committee (1998-1999 and 2004-2005)

Department of Veterans Affairs, VISN 16 – Tertiary Care Committee Cancer Care Subgroup (1998)

American Society for Therapeutic Radiology and Oncology – Program Committee (1999-2001), Teaching Faculty (2004-2009).

American Hernia Society – Organizing Committee, 2004

American Hernia Society – Board of Governors, 2004 – 2009

International Committees:

Malaysian Palm Oil Board (MPOB) Program Advisory Committee – Member (2017-2019).

International Commission for Radiation Protection (ICRP) – Full Member, Task Group on Tissue Injury (Deterministic Effects) and Other Non-Cancer Effects of Radiation (2005 – 2012).

TEACHING EXPERIENCE

Moderator, interdisciplinary cancer conference, John. L. McClellan VA Hospital, 1992-2011.

Course co-director, senior medical school elective, colorectal surgery and gastrointestinal endoscopy, 1992-2003.

Course director, institutional course in research methodology and biostatistics for clinicians, University of Arkansas for Medical Sciences and Arkansas Cancer Research Center, 1992-1999.

Student research projects supervised: UAMS Medical Students: John Allgood (1993), Jeff Bradley (1994), Mark Storey (1995-1996), Mitch Winkler (1996), Andrew Martine (1997), Brad Thomas (1998), Bradley Hughes (1995-2000, honors program), Brett Krepps (1997-2000, honors program), Charles Mashek (1999-2001), Nellie Norrell (2004), Joshua McElderry (2005), Christopher Ross (2004-2007, honors program), Richard A. Owings (2006-2009, honors program) Medical students from other universities: Anke Brandl (University of Jena, Germany, 2000).

Resident research projects supervised: Chris M. Albertson (Department of Pathology, 1998-2001) – recipient of the Academy of Clinical Laboratory Physicians and Scientists Paul E. Strandjord Young Investigator Award, 2000.

Masters projects supervised: Jennifer D. Carr, BS. UAMS Department of Pathology, MS degree awarded 6/1998. Thesis title: Granulocyte Marker Protein: A New, Non-Invasive Marker and Predictor of Intestinal Radiation Toxicity.

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PhD projects supervised: Carl W. Langberg, MD. University of Oslo, Norway, PhD degree awarded 8/1998. Thesis title: The Influence of Time, Dose, and Fractionation on Development of Chronic Radiation Enteropathy.

Konrad K. Richter, MD. University of Jena, Germany. PhD degree awarded 1/2001. Thesis title: Molecular and Cellular Pathogenesis, Monitoring, Prediction, and Radioprotection of Intestinal Radiation Injury. Habilitation Program.

Nils Hovdenak, MD. University of Bergen, Norway, PhD degree awarded 5/2004. Thesis title: Acute Radiation Proctitis: A Clinical, Histopathological, and Histochemical Study.

Maaike Berbee, MD. Maastricht University, Netherlands, PdD degree awarded 10/2011. Thesis title: Novel pharmacological strategies to reduce acute radiation injury.

PhD Committee Memberships: UAMS, Department of Physiology (candidate: Abhijit Shinde, MD). 6/2000.

Maastricht University, Department of Radiation Therapy and Oncology (candidate: Ludy

C.H.W. Lutgens, MD).12/2005.

Postdoctoral Fellows: Carl W. Langberg, MD (1989-1993)

Konrad K. Richter, MD (1994-1997)

Junru Wang, MD, PhD (1996-1999)

Huaien Zheng, MD, PhD (1997-2003)

Xiao Wang, PhD (2002-2003)

Jumei Shi, MD, PhD (2002-2003)

Wei Xu,DDM, PhD (2004-2005)

Marjan Boerma, PhD (2004-2006)

Maaike Berbée, MD (2007-2008)

Prabath Biju, PhD (2009-2011)

PROFESSIONAL SOCIETIES

Norway

Norwegian Medical Association (1977-present).

Norwegian Gastroenterological Society (1984-present).

Oslo Surgical Society (1985-present).

Norwegian Surgical Society (1985-present).

USA

Radiation Research Society (1986-present).

Pulaski County Medical Society (1991-present).

Arkansas Medical Society (1991-present).

American Medical Association (1991-present).

American Association for the Advancement of Science (1993-present).

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American College of Surgeons (1995-present).

Society of University Surgeons (1997-present).

American Society for Therapeutic Radiology and Oncology (1996-2017, Emeritus since 2017).

American Association of Pharmaceutical Scientists (2010-present).

American Hernia Society (1997-2019).

American Association for Cancer Research (1997-2015).

American Radium Society (1993-2015).

American Society for Investigative Pathology (2002-2014).

The Southwestern Surgical Congress (1992-2010).

Association for Academic Surgery (1993-2010).

Association for Surgical Education (1993-2010).

American Statistical Association (1995-2009).

Society of Surgical Oncology (1996-2010).

Society for Surgery of the Alimentary Tract (1997-2010).

International

European Society for Therapeutic Radiology and Oncology (1993-present).

Multinational Association of Supportive Care in Cancer (2001-present)

International Society on Thrombosis and Haemostasis (2001-2017)

European Society of Hyperthermic Oncology (1986-1995).

European Society of Surgical Oncology (1988-2007).

Nordic Surgical Society (1988-2009).

European Society for Surgical Research (1989-2009).

COPYRIGHTS

2N: Statistical software package: “MS Windows computer program for sample size estimation, power analysis, and generation of randomization table”, (US Copyright # TXu 585-961 [6/21/93]).

omniStat: Statistical software package: “MS Windows computer program for research design and statistical analysis”, (US Copyright # TXu 666-402 [12/27/94]).

d4STAT: Statistical software package: “MS-DOS computer program for statistical analysis of data in dBASE-compatible databases”, (US Copyright # TXu 688-894 [5/31/95]).

PATENTS

Issued: US Patent 6,540,976, issued 4/1/03: “Method for reducing radiation toxicity”. South Africa Patent, 98/8704, issued 8/30/03: “Method for reducing radiation

toxicity”. US Patent 9,309,547, issued 4/12/2016: “Methods for Making Tocoflexols and

Analogues Thereof”

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Pending: US Patent Application 20070238755: “Methods to Treat and/or Prevent Radiation and/or Chemical-Induced Toxicity in Non-Malignant Tissue”, filed December 20, 2006.

US Patent Application 20110144024: “Prevention and Treatment of Radiation Injury”, filed September 23, 2008.

US Patent Application 20100204254: “Use of Statins in the Prevention and

Treatment of Radiation Injury and Other Disorders Associated with Reduced

Endothelial Thrombomodulin”, filed August 12, 2010.

US Patent Application 20110144024: “Prevention and Treatment of Radiation

Injury”, filed June 16, 2011.

International Patent Application PCT/US2011/038933: “Tocopherol Derivatives

and Methods of Use”, filed February 6, 2011.

US Patent Application 20130158106: “Tocopherol Derivatives and Methods of

Use”, filed June 2, 2011.

International Patent Application PCT/US13/43264: “Methods for Treating

Radiation Injury Using Activated Protein C Polypeptides”, filed May 30, 2013.

US Patent Application 20160220530: “Preparation and Use of a Composition for

Prevention and Mitigatopm of the Effects of Radiation”, filed September 15, 2014.

US Patent Application #20160324914: “Use of Rice Bran Oil Distillate Extract for

Prevention and Mitigation of the Effects of Radiation”, filed May 5, 2016.

RELEVANT EXTRACURRICULAR ACTIVITIES AND EXPERIENCE

Toastmasters International (Communications and Leadership Program) 1986-1987.

Vestheim Rotary Club (Distr. 231), Oslo, Norway, 1982 - 1992.

Fluent in spoken and written Norwegian, Swedish, Danish, English, and German.

Outside interests: Classical music, opera, photography, chess, scuba-diving, tennis, skiing.

Hauer-Jensen

PUBLICATIONS

Martin Hauer-Jensen, MD, PhD, FACS

JOURNAL ARTICLES

1. Hauer-Jensen M, Carlsen E, Semb LS. Prognostic value of the pentagastrin and

insulin tests after proximal gastric vagotomy. Scand J Gastroent 1980;15:721-726.

2. Hauer-Jensen M, Aubert T, Johannesen J. Indikasjoner for peroperativ kolangiografi

ved elektive gallestensoperasjoner. (Indications for operative cholangiography in

elective gallstone surgery). Tidsskr Nor Laegeforen 1982;102:1759-1760.

3. Hauer-Jensen M, Carlsen E, Nygaard K. Tynntarmskade etter straaleterapi. (Injury

to the small intestine following radiation therapy). Tidsskr Nor Laegeforen

1983;103:133-135.

4. Hauer-Jensen M, Sauer T, Devik F, Nygaard K. Late changes following single dose

roentgen irradiation of rat small intestine. Acta Radiol Oncol 1983;22:299-303.

5. Hauer-Jensen M, Sauer T, Devik F, Nygaard K. Effects of dose fractionation on late

roentgen radiation damage of rat small intestine. Acta Radiol Oncol 1983;22:381-384.

6. Hauer-Jensen M, Dedichen H. Penetrating peptic ulcer and aortic aneurysm with

aorto-gastric fistula. Surgery 1984;95:756-758.

7. Hauer-Jensen M, Buanes T, Dedichen H. Primaer aortoenteral fistel. (Primary

aortoenteric fistulae). Tidsskr Nor Laegeforen 1984;104:1051-1052.

8. The Norwegian Study Group for Colorectal Surgery. Should antimicrobial

prophylaxis in colorectal surgery include agents effective against both anaerobic and

aerobic microorganisms? A double-blind, multicenter study. Surgery 1985;97:402-

408.

9. Hauer-Jensen M. Mikrodatamaskin. Hjelpemiddel i klinisk og eksperimentell

forskning. (The microcomputer as a tool in clinical and experimental research).

Tidsskr Nor Laegeforen 1985;105:898-900.

10. Hauer-Jensen M, Kaaresen R, Nygaard K, Solheim K, Amlie E, Havig O, Viddal

KO. Predictive ability of choledocholithiasis indicators. Ann Surg 1985;202:64-68

(PMCID: PMC1250838).

11. Hauer-Jensen M, Stromsoe K, Kvernebo K, Lunde OC, Vasli L, Krag L.

Kirurgutdannelsen. (Training in surgery.) Tidsskr Nor Laegeforen 1985;105:1991-

1993.

12. Hauer-Jensen M, Sauer T, Berstad T, Nygaard K. Influence of pancreatic secretion

on late radiation enteropathy in the rat. Acta Radiol Oncol 1985;24:555-560.

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Hauer-Jensen

13. Hauer-Jensen M, Kaaresen R, Nygaard K, Solheim K, Rosseland AR, Amlie E,

Havig O, Viddal KO. Peroperativ kolangiografi ved elektiv kolecystektomi.

(Intraoperative cholangiography during elective cholecystectomy). Tidsskr Nor

Laegeforen 1986;106:1559-1561.

14. Hauer-Jensen M, Sauer T, Sletten K, Reitan JB, Nygaard K. Value of

hydroxyproline measurements in the assessment of late radiation enteropathy. Acta

Radiol Oncol 1986;25:137-142.

15. Berstad A, Weberg R, Froyshov Larsen I, Hoel B, Hauer-Jensen M. Relationship of

hiatus hernia to reflux oesophagitis. A prospective study of coincidence, using

endoscopy. Scand J Gastroent 1986;21:55-58.

16. Hauer-Jensen M, Berstad T, Nygaard K. Pancreatic duct occlusion in the rat. Report

and assessment of a new technique. Proc Soc Exp Biol Med 1986;182:543-548.

17. Hauer-Jensen M, Sauer T, Reitan JB, Nygaard K. Late radiation enteropathy

following split-dose irradiation of rat small intestine. Acta Radiol Oncol

1986;25:203-206.

18. Hauer-Jensen M, Kaaresen R, Nygaard K, Solheim K, Amlie E, Havig O, Viddal

KO. Consequences of routine peroperative cholangiography during cholecystectomy

for gallstone disease: A prospective, randomized study. World J Surg 1986;10:996-

1002.

19. Hauer-Jensen M, Christensen K, Wilson HD, Schedl HP. Intestinal disaccharidase

activity following pancreatic duct occlusion in the rat. Pancreas 1987;2:295-302.

20. Hauer-Jensen M, Poulakos L, Milani FX, Osborne JW. Effects of exocrine

pancreatic secretions on hyperthermic injury of rat small intestine. Int J Hyperthermia

1988;4:417-426.

21. Poulakos L, Elwell JH, Osborne JW, Urdaneta LF, Hauer-Jensen M, Vigliotti AP,

Hussey DH, Summers RW. Intraoperative irradiation in a rat model:

Histopathological changes in irradiated segments of duodenum. J Surg Oncol

1988;38:130-135.

22. Hauer-Jensen M, Wilson HD, Schedl HP. Morphologic and functional recovery of

rat small intestine following localized hyperthermia. Int J Hyperthermia 1988;4:527-

535.

23. Hauer-Jensen M, Poulakos L, Osborne JW. Effects of accelerated fractionation on

radiation injury of the small intestine: A new rat model. Int J Radiat Oncol Biol Phys

1988;14:1205-1212.

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Hauer-Jensen

24. Svennevig JL, Semb G, Fjeld NB, Klingen G, Wickstrom E, Jorgensen JJ, Abdelnoor

M, Hauer-Jensen M, Sivertsen E. Surgical treatment of left ventricular aneurysm.

Analysis of risk factors, morbidity, and mortality in 205 patients. Scand J Thorac

Cardiovasc Surg 1989;23:229-234.

25. Hauer-Jensen M, Poulakos L, Osborne JW. Intestinal complications following

accelerated fractionated X-irradiation: An experimental study in the rat. Acta Oncol

1990;29:229-234.

26. Poulakos L, Elwell JH, Osborne JW, Urdaneta LF, Hauer-Jensen M, Vigliotti AP,

Hussey DH, Summers RW. The prevalence and severity of late effects in normal rat

duodenum following intraoperative irradiation. Int J Radiat Oncol Biol Phys

1990;8:841-848.

27. Hauer-Jensen M. Late radiation injury of the small intestine. Clinical,

pathophysiologic, and radiobiologic aspects. Acta Oncol 1990;29:401-415.

28. Grabner P, Hauer-Jensen M, Jervell J, Flatmark A. Long term results of treatment of

Cushing's disease by adrenal surgery. Eur J Surg 1991;157:461-464.

29. Hauer-Jensen M. Statistical analysis in dBASE compatible databases. Comput Appl

Biosci 1991;7:61-62.

30. Tanum G, Tveit KM, Karlsen KO, Hauer-Jensen M. Chemoradiotherapy of anal

carcinoma: Survival and late morbidity. Cancer 1991;67:2462-2466.

31. Langberg CW, Sauer T, Reitan JB, Hauer-Jensen M. Tolerance of rat small intestine

to localized single dose and fractionated irradiation. Acta Oncol 1992;31:781-787.

32. Hauer-Jensen M. Et verdifullt søkeprogram for Medline. (A valuable search

program for Medline.) Tidsskr Nor Laegeforen 1992; 112:1622.

33. Hauer-Jensen M. Lymphadenectomy in resection of gastric carcinoma. Curr Surg

1992;49:276-280.

34. Hauer-Jensen M, Kaaresen R, Nygaard K, Solheim K, Amlie EJB, Havig O,

Rosseland AR. Prospective, randomized study of routine intraoperative

cholangiography during open cholecystectomy. Long term follow-up and multivariate

analysis of predictors of choledocholithiasis. Surgery 1993;113:318-323.

35. Read RC, Barone GW, Hauer-Jensen M, Yoder G. Properitoneal prosthetic

placement through the groin. The anterior (Mahorner-Goss, Rives-Stoppa) approach.

Surg Clin North Am 1993;73:545-555.

36. Hauer-Jensen M. Research project design in Windows. Sample size calculation,

power analysis, and randomization. Comput Appl Biosci 1993;9:45-47.

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Hauer-Jensen

37. Cozart DT, Lang NP, Hauer-Jensen M, Southwestern Surgical Congress Unusual

Case Registry. Colorectal cancer in patients under 30 years of age. Am J Surg

1993;166:764-767.

38. Langberg CW, Waldron JA, Baker ML, Hauer-Jensen M. Significance of overall

treatment time for the development of radiation-induced intestinal complications. An

experimental study in the rat. Cancer 1994;73:2663-2668.

39. Vitti MJ, Robinson DV, Hauer-Jensen M, Thompson BW, Ranval TJ, Barone G,

Barnes RW, Eidt JF. Wound healing in forefoot amputations: The predictive value of

toe pressure. Ann Vasc Surg 1994;8:99-106.

40. Langberg CW, Hauer-Jensen M, Sung C-C, Kane CJM. Expression of fibrogenic

cytokines in rat small intestine after fractionated irradiation. Radiother Oncol

1994;32:29-36.

41. Lang NP, Butler MA, Massengill J, Lawson M, Stotts RC, Hauer-Jensen M,

Kadlubar FF. Rapid metabolic phenotypes for acetyltransferase and cytochrome

P4501A2 and putative exposure to food-borne heterocyclic amines increases the risk

for colorectal cancer and polyps. Cancer Epidemiol Biomarkers Prev 1994;3:675-682.

42. Husebye E, Hauer-Jensen M, Kjorstad K, Skar V. Severe late radiation enteropathy

is characterized by impaired motility of proximal small intestine. Dig Dis Sci,

1994;39:2341-2349.

43. Langberg CW, Sauer T, Reitan JB, Hauer-Jensen M. Influence of fractionation

schedule on development of intestinal complications following localized irradiation.

An experimental study in the rat. Acta Oncol 1994;33:403-408.

44. Scott BR, Langberg CW, Hauer-Jensen M. Models for estimating the risk of ulcers

in the small intestine after localized single or fractionated irradiation. Br J Radiol

1995;68:49-57.

45. Hauer-Jensen M, Skjonsberg G, Moen E, Clausen OPF. Intestinal morphology and

cytokinetics in pancreatic insufficiency. An experimental study in the rat. Dig Dis Sci

1995;40:2170-2176.

46. Hauer-Jensen M, Theus JW, Bradley JD, Baker ML, Langberg CW. Localized

subclinical radiation enteropathy prolongs intestinal transit time: An experimental

study in a rat model. Radiat Oncol Invest 1995;3:157-166.

47. Hauer-Jensen M. Peer review of scientific manuscripts. An old system in need of

reform. JIR 1996;41:16-17.

48. Langberg CW, Sauer T, Reitan JB, Hauer-Jensen M. Relationship between intestinal

fibrosis and histopathologic and morphometric changes in consequential and late

radiation enteropathy. Acta Oncol 1996;35:81-87.

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Hauer-Jensen

49. Langberg CW, Hauer-Jensen M. Influence of fraction size on the development of

late radiation enteropathy. Acta Oncol 1996;35:89-94.

50. Barnes JR, Lucas N, Broadwater JR, Hauer-Jensen M. When should the “infected” subcutaneous infusion reservoir be removed? Am Surg 1996;62:203-206.

51. Allgood JW, Langberg CW, Sung CC, Hauer-Jensen M. Timing of concomitant

boost irradiation affects incidence and severity of intestinal complications. Int J

Radiat Oncol Biol Phys1996;34:381-387.

52. Richter KK, Langberg CW, Sung CC, Hauer-Jensen M. Association of transforming

growth factor (TGF-) immunoreactivity with specific histopathologic lesions in

subacute and chronic experimental radiation enteropathy. Radiother Oncol

1996;39:243-251.

53. Langberg CW, Hauer-Jensen M. Optimal interfraction interval to minimize small

bowel radiation injury in treatment regimens with 2 fractions per day. Radiother

Oncol 1996;41:249-255.

54. Gagne PJ, Matchett J, MacFarland D, Hauer-Jensen M, Barone GW, Eidt JF, Barnes

RW. Can the NASCET technique for measuring carotid stenosis be reliably applied

outside the trial? J Vasc Surg 1996;24:449-455.

55. Gagne PJ, Vitti MJ, Fink LM, Duncan J, Nix ML, Barnes RW, Hauer-Jensen M,

Barone GW, Eidt JF. Young women with advanced aortoiliac occlusive disease: new

insights. Ann Vasc Surg 1996;10:546-557.

56. Richter KK, Fink LM, Hughes BM, Sung CC, Hauer-Jensen M. Is loss of

endothelial thrombomodulin involved in the mechanism of chronicity in late radiation

enteropathy? Radiother Oncol 1997;44:65-71.

57. Brown DF, Muirhead MJ, Travis PM, Vire SR, Weller J, Hauer-Jensen M. Mode of

chemotherapy does not affect complications in an implantable venous access device.

Cancer 1997;80:966-972.

58. Richter KK, Langberg CW, Sung CC, Hauer-Jensen M. Increased transforming

growth factor (TGF-) immunoreactivity is independently associated with chronic

injury in both consequential and primary radiation enteropathy. Int J Radiat Oncol

Biol Phys 1997;39:187-195.

59. Richter KK, Fagerhol MK, Carr JC, Winkler JM, Sung CC, Hauer-Jensen M.

Association of granulocyte transmigration with structural and cellular parameters of

injury in experimental radiation enteropathy. Radiat Oncol Invest 1997;5:275-282.

60. Wang J, Zheng H, Sung C-C, Richter KK, Hauer-Jensen M. Cellular sources of

transforming growth factor (TGF-) isoforms in early and chronic radiation

enteropathy. Am J Pathol 1998;153:1531-1540 (PMCID: PMC1853410).

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Hauer-Jensen

61. Abe O, Abe R, Enomoto K, Kikuchi K, Koyama H, Nomura Y, Sakai K, Sugimachi

K, ……., Hauer-Jensen M, ………, Caffier H: Polychemotherapy for early breast

cancer: an overview of the randomised trials. Lancet 1998;352:930-942.

62. Hauer-Jensen M, Richter KK, Wang J, Abe E, Sung C-C, Hardin JW. Changes in

transforming growth factor 1 (TGF-1) gene expression and immunoreactivity

levels during development of chronic radiation enteropathy. Radiat Res

1998;150:673-680.

63. Raufman, JP, Hauer-Jensen M. Ileo-cecal tuberculosis. Gastrointest Endosc

1998;48:617.

64. Richter KK, Fink LM, Hughes BM, Shmaysani HM, Sung C-C, Hauer-Jensen M.

Differential effect of radiation on endothelial cell function in rectal cancer and normal

rectum. Am J Surg 1998;176:642-647.

65. Yao A, Wang J, Fink LM, Hardin JW, Hauer-Jensen M. Molecular cloning and

sequence analysis of the 5'-flanking region of the Sprague-Dawley rat

thrombomodulin gene. DNA Sequence 1999;10:55-60.

66. Storey MR, Landgren RC, Cottone JL, Stallings JW, Logan CW, Fraiser LP, Ross

CS, Kock RJ, Berkley LW, Hauer-Jensen M. Transperineal Iodine 125implantation

for treatment of clinically localized prostate cancer: 5 year tumor control and

morbidity. Int J Radiat Oncol Biol Phys 1999;43:565-570.

67. Wang J, Richter KK, Sung C-C, Hauer-Jensen M. Upregulation and spatial shift in

the localization of the mannose 6-phosphate/insulin-like growth factor II receptor in

radiation enteropathy development in the rat. Radiother Oncol 1999;50:205-213.

68. Wang J, Yao A, Wang J-Y, Fink LM, Hardin JW, Hauer-Jensen M. cDNA cloning

and sequencing, gene expression, and immunolocalization of thrombomodulin in the

Sprague-Dawley rat. DNA Research 1999;6:57-62.

69. James JD, Hauer-Jensen M. Significance of fixation time for quantitative

computerized immunohistochemistry. J Histotechnol 1999;22:109-111.

70. Hauer-Jensen M, Kong FM, Fink, LM, Anscher MS. Circulating thrombomodulin

during radiation therapy of lung cancer. Radiat Oncol Invest 1999;7:238-242.

71. Wang J, Zheng H, Sung C-C, Hauer-Jensen M. The synthetic somatostatin analogue,

octreotide, ameliorates acute and delayed intestinal radiation injury. Int J Radiat

Oncol Biol Phys 1999;45:1289-1296.

72. Zheng H, Wang J, Sung C-C, Hauer-Jensen M. Role of mast cells in the

pathogenesis of early and delayed radiation injury in rat intestine. Radiat Res

2000;153:533-539.

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Hauer-Jensen

73. Read RC, Barnes RW, Eidt JF, Hauer-Jensen M, Moursi MM. Femorofemoral

arterial bypass: subcutaneous or preperitoneal? Vasc Surg 2000;34:337-344.

74. Govindarajan R, Heaton KM, Broadwater R, Zeitlin A, Lang NP, Hauer-Jensen M:

Effect of thalidomide on gastrointestinal toxic effects of irinotecan. Lancet

2000;356:566-567.

75. Denham JW, Hauer-Jensen M, Kron T, Langberg CW: Treatment time dependence

models of early and delayed radiation injury in rat small intestine. Int J Radiat Oncol

Biol Phys 2000;48:871-887.

76. Hovdenak N, Fajardo LF, Hauer-Jensen M: Early radiation proctitis: a sequential

clinicopathologic study during pelvic radiotherapy. Int J Radiat Oncol Biol Phys

2000;48:1111-1117.

77. Zheng H, Wang J, Koteliansky VE, Gotwals PJ, Hauer-Jensen M: Recombinant

soluble transforming growth factor-β type II receptor ameliorates radiation-induced

fibrosis in mouse intestine. Gastroenterology 2000;119:1286-1296.

78. Mumtaz H, Williams V, Hauer-Jensen M, Rowe M, Henry-Tillman RS, Heaton K,

Mancino AT, Muldoon RL, Klimberg VS, Broadwater JR, Westbrook KC, Lang NP.

Central venous catheter placement in patients with disorders of hemostasis. Am J

Surg 2000;180:503-506.

79. Richter KK, Wang J, Fagerhol MK, Hauer-Jensen M: Radiation-induced

granulocyte transmigration predicts development of delayed structural changes in rat

intestine. Radiother Oncol 2001;59:81-85.

80. Wang J, Zheng H, Hauer-Jensen, M: Influence of short-term octreotide

administration on chronic tissue injury, transforming growth factor β (TGF-β) overexpression, and collagen accumulation in irradiated rat intestine. J Pharmacol

Exp Ther 2001;297:35-42.

81. Denham JW, Hauer-Jensen M, Peters LJ: Editorial: Is it time for a new formalism to

categorise normal tissue radiation injury? Int J Radiat Oncol Biol Phys 2001;50:1105-

1106.

82. Albertson CM, Richter KK, Kudryk BJ, Fink LM, Hauer-Jensen M: Association

between decreased pulmonary endothelial cell thrombomodulin and local fibrin

deposition in pneumonia. Blood Coagul Fibrinolysis 2001;12:729-733.

83. Wang J, Albertson CM, Zheng H, Fink LM, Herbert J-M, Hauer-Jensen M: Short-

term inhibition of ADP-induced platelet aggregation by clopidogrel ameliorates

radiation-induced toxicity in rat small intestine. Thromb Haemost 2002;87:122-128.

84. Joseph L, Fink LM, Hauer-Jensen M: Cytokines in coagulation and thrombosis - A

preclinical and clinical review. Blood Coagul Fibrinolysis 2002;13:105-116.

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Hauer-Jensen

85. Denham JW, Hauer-Jensen M: The radiotherapeutic injury – a complex ‘wound’. Radiother Oncol 2002;63:129-145.

86. Wang J, Zheng H, Ou X, Fink LM, Hauer-Jensen M: Deficiency of microvascular

thrombomodulin and upregulation of protease-activated receptor 1 in irradiated rat

intestine: possible link between endothelial dysfunction and chronic radiation fibrosis.

Am J Pathol 2002;160:2063-2072 (PMCID: PMC1850827).

87. Hovdenak N, Wang J, Sung C-C, Kelly T, Fajardo LF, Hauer-Jensen M: Clinical

significance of increased gelatinolytic activity in the rectal mucosa during external

beam radiation therapy of prostate cancer. Int J Radiat Oncol Biol Phys 2002;53:919-

927.

88. Joseph J, Washington A, Joseph L, Ranganathan S, Koehler L, Fink LM,

Hauer-Jensen M, Kennedy RH: Hyperhomocysteinemia leads to adverse cardiac

remodeling in hypertensive rats. Am J Physiol 2002;283:H2567-H2574.

89. Cone JB, Ferrer TJ, Wallace BH, Wang J, Hauer-Jensen M: Alterations in

endothelial thrombomodulin expression in zymosan-induced lung injury. J Trauma

2003;54:731-736.

90. Joseph J, Joseph L, Shekhawat NS, Devi S, Hauer-Jensen M, Kennedy RH:

Hyperhomocysteinemia leads to pathologic ventricular hypertrophy in normotensive

rats. Am J Physiol 2003;285:H679-H686.

91. Hauer-Jensen M, Wang J, Denham JW: Bowel injury – current and evolving

management strategies. Semin Radiat Oncol 2003;13:358-371.

92. Bentzen SM, Dorr W, Anscher MS, Denham JW, Hauer-Jensen M, Marks LB,

Williams J: Normal Tissue Effects: Reporting and Analysis. Semin Radiat Oncol

2003;13:189-202.

93. Shi J, Wang J, Zheng H, Ling W, Joseph J, Li D, Mehta JL, Ponnappan U, Lin P, Fink

LM, Hauer-Jensen M: Statins increase thrombomodulin expression and function in

human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor

necrosis factor alpha-induced thrombomodulin downregulation. Blood Coagul

Fibrinolysis 2003;14:575-585.

94. Wang J, Hauer-Jensen M: Radiation toxicity and proteinase activated receptors.

Drug Dev Res 2003;60:1-8.

95. Wang J, Zheng H, Hollenberg MD, Vijesuriya SJ, Ou X, Hauer-Jensen M:

Upregulation and activation of proteinase-activated receptor-2 (PAR-2) in early and

delayed radiation injury in the rat intestine: influence of biological PAR-2 activators.

Radiat Res 2003;160:524-535.

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Hauer-Jensen

96. Keefe DMK, Gibson RJ, Hauer-Jensen M: Gastrointestinal mucositis. Semin Oncol

Nurs 2004;20:38-47.

97. Muldoon RL, Marchant K, Johnson DD, Read RC, Yoder GG, Hauer-Jensen M:

Lichtenstein versus anterior preperitoneal prosthetic mesh placement in open inguinal

hernia repair – a prospective, randomized trial. Hernia 2004;8:98-103.

98. Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, Bekele

BN, Raber-Durlacher J, Donnely JP, Rubenstein EB: Perspectives on cancer therapy–induced mucosal injury: pathogenesis, measurement, epidemiology, and

consequences for patients. Cancer 2004;100:1995-2025.

99. Hauer-Jensen M, Fink LM, Wang J: Radiation injury and the thrombomodulin-

protein C pathway. Crit Care Med 2004;32:S325-S330.

100. Wang J, Zheng H, Ou X, Albertson CM, Fink LM, Herbert J-M, Hauer-Jensen M:

Hirudin ameliorates intestinal radiation toxicity in the rat: support for thrombin

inhibition as strategy to minimize side effects after radiation therapy and as

countermeasure against radiation exposure. J Thromb Haemost 2004;2:2027-2035.

101. Stone HB, Moulder JE, Coleman NC, Ang KA, Anscher MS, Barcellos-Hoff MH,

Dynan WS, Fike JR, Grdina DJ, Greenberger JS, Hauer-Jensen M, Hill RP,

Kolesnick RN, MacVittie TJ, Marks C, McBride WH, Metting N, Pellmar T,

Purucker M, Robbins ME, Schiestl RH, Seed TM, Tomaszewski JE, Travis EL,

Wallner PE, Wolpert M, Zaharevitz D: Models for evaluating agents intended for the

prophylaxis, mitigation and treatment of radiation injuries. Radiat Res 2004;162:711-

728.

102. Kennedy RH, Hauer-Jensen M, Joseph J: Cardiac function in hearts isolated from a

rat model deficient in mast cells. Am J Physiol 2005;288:H632-H637.

103. Abe O, Abe R, Enomoto K, Kikuchi K, Koyama H, Masuda H, Nomura Y, Sakai K,

……….., Hauer-Jensen M, …………Caffier H: Effects of chemotherapy and

hormonal therapy for early breast cancer on recurrence and 15-year survival: an

overview of the randomised trials. Lancet 2005;365:1687-1717.

104. Boerma M, Wang J, Wondergem J, Joseph J, Qiu X, Kennedy RH, Hauer-Jensen M:

Influence of mast cells on structural and functional manifestations of radiation-

induced heart disease. Cancer Res 2005;65:3100-3106.

105. Joseph J, Kennedy RH, Devi S, Wang J, Joseph L, Hauer-Jensen M: Protective role

of mast cells in homocysteine-induced cardiac remodeling. Am J Physiol

2005:288:2541-2545.

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Hauer-Jensen

106. Wang J, Zheng H, Qiu X, Kulkarni A, Fink LM, Hauer-Jensen M: Modulation of

the intestinal response to ionizing radiation by anticoagulant and non-anticoagulant

heparins. Thromb Haemost 2005;94:1054-1059.

107. Abe O, Abe R, Enomoto K, Kikuchi K, Koyama H, Masuda H, Nomura Y, Sakai K,

……….., Hauer-Jensen M, …………Caffier H: Effects of radiotherapy and of

differences in the extent of surgery for early breast cancer on local recurrence and 15-

year survival: an overview of the randomised trials. Lancet 2005;366:2087-2106.

108. Wang J, Zheng H, Kulkarni A, Ou X, Hauer-Jensen M: Regulation of early and

delayed radiation responses in rat small intestine by capsaicin-sensitive nerves. Int J

Radiat Oncol Biol Phys 2006;64:1528-1536.

109. Hauer-Jensen M, Fort C, Mehta JL, Fink LM: Influence of statins on postoperative

wound complications after inguinal or ventral herniorrhaphy. Hernia 2006;10:48-52.

110. Boerma M, Burton GR, Wang J, Fink LM, McGehee RE, Hauer-Jensen M:

Comparative expression profiling in primary and immortalized endothelial cells:

changes in gene expression in response to HMG-CoA reductase inhibition. Blood

Coagul Fibrinolysis 2006;17:173-80.

111. Kennedy RH, Owings R, Joseph J, Melchert RB, Hauer-Jensen M, Boerma M:

Acute dilatory and negative inotropic effects of homocysteine are inhibited by an

adenosine blocker. Clin Exp Pharmacol Physiol 2006;33:340-344.

112. Wang J, Qiu X, Kulkarni A, Hauer-Jensen M: Calcitonin gene-related peptide and

substance P regulate the intestinal radiation response. Clin Cancer Res 2006;12:4112-

4118.

113. Mehta JL,Bursac Z, Hauer-Jensen M, Fort C, Fink LM: Use of statins and reduction

in mortality in a US veteran population. Am J Cardiol 2006;98:923-928.

114. Boerma M, Wang J, Richter KK, Hauer-Jensen M: Orazipone, a locally acting

immunomodulator, ameliorates intestinal radiation injury: A preclinical study in a

novel rat model. Int J Radiat Oncol Biol Phys 2006;66:552-559.

115. Wang J, Boerma M, Fu Qiang, Hauer-Jensen M: Radiation responses in skin and

connective tissues: influence on wound healing and surgical outcome. Hernia

2006;10:502-506.

116. Boerma M, Fiser WP, Hoyt G, Berry GJ, Joseph L, Joseph J, Wang J, Crew MD,

Robbins RC, Hauer-Jensen M: Influence of mast cells on outcome after heterotopic

cardiac transplantation in rats. Transpl Int 2007;20:256-265.

117. Hauer-Jensen M, Wang J, Boerma M, Fu Qiang, Denham JW: Radiation damage to

the gastrointestinal tract: mechanisms, diagnosis, and management. Curr Opin Palliat

Support Care 2007;1:23-29.

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Hauer-Jensen

118. Wang J, Boerma M, Qiang F, Hauer-Jensen M: Significance of endothelial

dysfunction in the pathogenesis of early and delayed radiation enteropathy. World J

Gastroenterol 2007;13:3047-3055.

119. Larsen A, Reitan JB, Aase S, Hauer-Jensen M: Long-term prognosis in patients with

severe late radiation enteropathy: a prospective cohort study. World J Gastroenterol

2007;13:3610-3613.

120. Wang J, Hauer-Jensen M: Neuroimmune interactions in the gut: potential target for

mitigating or treating intestinal radiation injury. Br J Radiol 2007:80;S41-S48.

121. Wang J, Boerma M, Fu Q, Fink LM, Hauer-Jensen M: Simvastatin ameliorates

radiation enteropathy development after localized, fractionated irradiation by a protein

C-independent mechanism. Int J Radiat Oncol Biol Phys 2007;68:1483-1490 (PMCID:

PMC2000701).

122. Boerma M, Wang J, Burnett AF, Santin AD, Roman JJ, Hauer-Jensen M: Local

administration of interleukin-11 ameliorates intestinal radiation injury. Cancer Res

2007;67:9501-9506.

123. Ross, CC, MacLeod SL, Plaxco JR, Froud JW, Fink LM, Wang J, Stites WE, Hauer-

Jensen M: Inactivation of thrombomodulin by ionizing radiation in a cell-free

system: possible implications for radiation responses in vascular endothelium. Radiat

Res 2008;169:408-416. (PMCID: PMC2568889)

124. Levick SP, Gardner JD, Holland M, Hauer-Jensen M, Janicki JS, Brower GL:

Protection from adverse myocardial remodeling secondary to chronic volume

overload in mast cell deficient rats. J Mol Cell Cardiol 2008;45:56-61. (PMCID:

PMC3272272)

125. Fu Q, Wang J,Boerma M, Berbee M, Qiu X, Fink LM, Hauer-Jensen M:

Involvement of heat shock factor 1 in statin-induced transcriptional upregulation of

endothelial thrombomodulin. Circ Res 2008;103:369-377. (PMCID: PMC2562544)

126. Boerma M, Wang J, Kulkarni A, Roberto KA, Qiu X, Kennedy RH,

Hauer-Jensen M: Influence of endothelin-1 receptor inhibition on functional,

structural and molecular changes in the rat heart after irradiation. Radiat Res

2008;170:275-283. (PMCID: PMC2680502)

127. Milovanova TN, Bhopale VM, Sorokina EM, Moore JS, Hunt TK, Hauer-Jensen M,

Velazquez OC, Thom SR: Lactate stimulates vasculogenic stem cells via the

thioredoxin system and engages an autocrine activation loop involving hypoxia

inducible factor-1. Mol Cell Biol 2008;28:6248-6261. (PMCID: PMC2577432)

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Hauer-Jensen

128. Boerma M, Fu Q, Wang J, Loose DL, Bartolozzi A, Ellis JL, McGonigle S, Paradise

E, Sweetnam P, Fink LM, Vozenin-Brotons MC, Hauer-Jensen M: Comparative

gene expression profiling in three primary human cell lines after treatment with a

novel inhibitor of Rho kinase or atorvastatin. Blood Coagul Fibrinolysis 2008; 9:709-

718. (PMCID: PMC2713681)

129. Boerma M, Roberto KA, Hauer-Jensen M: Prevention and treatment of functional

and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol.

Int J Radiat Oncol Biol Phys 2008;72:170-177. (PMCID: PMC2574608)

130. Richter GT, Bowen T, Boerma M, Fan CY, Hauer-Jensen M, Vural E: Impact of

vascular endothelial growth factor on skin graft survival in irradiated rats. Arch Facial

Plast Surg 2009;11:110-113.

131. Berbee M, Fu Q, Boerma M, Wang J, Kumar KS, Hauer-Jensen M: Gamma-

tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative

stress after total body irradiation by an HMG-CoA reductase-dependent mechanism.

Radiat Res 2009;171:596-605. (PMCID: PMC2713014)

132. Hauer-Jensen M, Bursac Z, Read RC: Is herniosis the single etiology of Saint’s Triad? Hernia 2009;13:29-34.

133. Milovanova TN, Bhopale VM, Sorokina EM, Moore JS, Hunt TK, Hauer-Jensen M,

Velazquez OC, Thom SR: Hyperbaric oxygen stimulates vasculogenic stem cell

growth and differentiation in vivo. J Appl Physiol 2009;106:711-728. (PMCID:

PMC2644249)

134. Fu Q, Berbee M, Boerma M, Wang J, Schmid HA, Hauer-Jensen M: The

somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa

and increases survival after total body irradiation by inhibiting exocrine pancreatic

secretion. Radiat Res 2009;171:698-707. (PMCID: PMC2742953)

135. Ghosh SP, Kulkarni S, Hieber K, Toles R, Romanuykha L, Kao TC, Hauer-Jensen

M, Kumar KS: Gamma-tocotrienol, a tocol antioxidant as a potent radiation

countermeasure. Int J Radiat Biol 2009;85:598-606.

136. Valuckaite V, Zaborina O, Long J, Hauer-Jensen M, Wang J, Holbrook C, Zaborin

A, Drabik K, Katdare M, Mauceri H, Weichselbaum R, Firestone MA, Lee KY,

Chang EB, Matthews J, Alverdy JC: Oral PEG 15-20 protects the intestine against

radiation: role of lipid rafts. Am J Physiol 2009;297:G1041-G1052. (PMCID:

PMC2850088)

137. Owings RA, Boerma M, Wang J, Berbee M, Laderoute KR, Soderberg LS, Vural E,

Hauer-Jensen M: Selective Deficiency of HIF-1α in myeloid cells influences

secondary intention wound healing in mouse skin. In Vivo 2009;23:879-84.

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Hauer-Jensen

138. Garg S, Boerma M, Wang J, Fu Q, Loose DS, Kumar KS, Hauer-Jensen M:

Influence of sublethal total body irradiation on immune cell populations in the

intestinal mucosa. Radiat Res 2010;173:469-478. (PMCID: PMC2863351)

139. Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, Kirsch

DG, MacVittie TJ, Mason KA, Medhora MM, Moulder JE, Okunieff P, Otterson MF,

Robbins ME, Smathers JB, McBride WH: Animal models for medical

countermeasures to radiation exposure. Radiat Res 2010;173:557-578. (PMCID:

PMC3021126)

140. Andreyev JN, Wotherspoon A, Denham JW, Hauer-Jensen M: “Pelvic Radiation Disease”: defining a new condition in the survivorship era. Lancet Oncol 2010;11:310-

312.

141. Kodell RL, Lensing SY, Landes RD, Kumar KS, Hauer-Jensen M: Determination of

sample sizes for demonstrating efficacy of radiation countermeasures. Biometrics

2010;66:239-248. (PMCID: PMC3036987)

142. Cui L, Pierce D, Light KE, Melchert RB, Fu Q, Kumar KS, Hauer-Jensen, M:

Sublethal total body irradiation leads to early cerebellar damage and oxidative stress.

Curr Neurovasc Res 2010;7:125-135. (PMCID: PMC3637794)

143. Kulkarni S, Ghosh SP, Satyamitra M, Mog S, Hieber K, Romanyukha L, Gambles K,

Toles R, Kao TC, Hauer-Jensen M, Kumar KS: Gamma-tocotrienol protects

hematopoietic stem and progenitor cells in mice after total-body irradiation. Radiat

Res 2010;173:738-747.

144. Wang J, Boerma M, Kulkarni A, Hollenberg MD, Hauer-Jensen M: Activation of

protease activated receptor 2 (PAR2) by an exogenous agonist exacerbates early

radiation injury in rat intestine. Int J Radiat Oncol Biol Phys 2010;77:1206-1212.

(PMCID: PMC2901891)

145. Vural E, Berbee M, Acott A, Blagg R, Fan CY, Hauer-Jensen, M: Skin graft take

rates, granulation, and epithelialization: dependence on myeloid cell HIF-1α. Arch

Otolaryngol Head Neck Surg 2010;136:720-723. (PMCID: PMC3268655)

146. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) [incl. Hauer-Jensen,

M], Correa C, McGale P, Tailor C, Wang Y, Clarke M, Davies C, Peto R, Bijker N,

Solin L, Darby S: Overview of the randomized trials of radiotherapy in ductal

carcinoma in situ of the breast. J Natl Cancer Inst Monogr 2010;2010;162-177. (PMID:

20334614)

147. Boerma M, Hauer-Jensen, M: Potential targets for intervention in radiation-induced

heart disease. Current Drug Targets 2010;11:1405-1412. (PMCID: PMC3311026)

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Hauer-Jensen

148. Berbee M, Fu Q, Kumar KS, Hauer-Jensen, M: Novel strategies to ameliorate

radiation injury: a possible role for tetrahydrobiopterin. Curr Drug Targets

2010;11:1366-1374. (PMCID: PMC3311028)

149. Hauer-Jensen, M, Kumar KS: Targets of potential radioprotective drugs. Curr Drug

Targets 2010;11:1351.

150. Kulkarni S, Ghosh SP, Hauer-Jensen, M, Kumar KS: Hematological targets of

radiation damage. Curr Drug Targets 2010;11:1375-85.

151. Boerma M, Hauer-Jensen, M: Pre-clinical research into basic mechanisms of

radiation-induced heart disease. Cardiol Res Pract 2010;2011:1-8, pii 858262.

(PMCID: PMC2952915)

152. Berbee M, Fu Q, Boerma M, Pathak R, Zhou D, Kumar KS, Hauer-Jensen, M:

Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog, γ-

tocotrienol: evidence of a role for tetrahydrobiopterin. Int J Radiat Oncol Biol Phys

2011;79:884-891. (PMCID: PMC3023840)

153. Berbee M, Fu Q, Garg S, Kulkarni S, Kumar KS, Hauer-Jensen, M: Pentoxifylline

enhances the radioprotective properties of γ-tocotrienol: differential effects on the

hematopoietic, gastrointestinal, and vascular system. Radiat Res 2011;175:297-306.

(PMCID: PMC3115470)

154. Palmer JL, Deburghgraeve DR, Bird, MD, Hauer-Jensen, M, Kovacs EJ:

Development of a combined radiation and burn injury model. J Burn Care Res

2011;32:317-323. (PMCID: PMC3062624)

155. Movsas B, Vikram B, Hauer-Jensen M, Moulder J, Basch E, Brown SL, Lachnic LA,

Dicker AP, Coleman CN, Okunieff P: Decreasing the adverse effects of cancer

therapy: National Cancer Institute guidance for the clinical development of radiation

injury mitigators. Clin Cancer Res 2011;17:222-228.

156. Wu L, Shao L, An N, Wang J, Pazhanisamy S, Feng W, Hauer-Jensen M,

Miyamoto S, Zhou D: IKKβ regulates the repair of DNA double-strand breaks induced

by ionizing radiation in MCF-7 breast cancer cells. PLoS One 2011;6(4),e18447:1-10.

(PMCID: PMC3072401)

157. Andreyev JN, Wotherspoon A, Denham JW, Hauer-Jensen M: “Pelvic radiation

disease”: new understanding and new solutions for a new disease in the era of cancer survivorship. Scand J Gastroenterol 2011;46:389-397.

158. Fu Q, Berbee M, Wang W, Boerma M, Wang J, Schmid HA, Hauer-Jensen M:

Preclinical evaluation of SOM230 as a radiation mitigator in a mouse model: post-

exposure time window and mechanisms of action. Radiat Res 2011;175:728-735.

(PMCID: PMC3118638)

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Hauer-Jensen

159. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) [incl. Hauer-Jensen,

M], Davies C, Godwin J, Gray R, Clarke M, Cutter D, Darby S, McGale P, Pan HC,

Taylor C, Wang YC, Dowsett M, Ingle J, Peto R: Relevance of breast cancer

hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-

level meta-analysis of randomised trials. Lancet 2011;378:771-784. (PMCID:

PMC3163848)

160. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) [incl. Hauer-Jensen,

M], Darby S, McGale P, Correa C, Taylor C, Amagada R, Clarke M, Cutter D,

Davies C, Ewertz M, Godwin J, Gray R, Pierce L, Whelan T, Wang Y, Peto R: Effect

of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year

breast cancer death: meta-analysis of individual patient data for 10,801 women in 17

randomised trials. Lancet 2011;378:1707-1716. (PMCID: PMC3254252)

161. Alipio ZA, Jones N, Liao W, Yang J, Kulkarni S, Kumar KS, Hauer-Jensen M,

Ward DC, Ma Y, Fink LM: Epithelial to mesenchymal transition (EMT) induced by

bleomycin or TFGb1/EGF in murine induced pluripotent stem cell-derived alveolar

type II-like cells. Differentiation 2011;82:89-98.

162. Gupta PK, Brown J, Biju PG, Thaden J, Deutz NE, Kumar S, Hauer-Jensen M,

Hendrickson HP: Development of high-throughput HILIC-MS/MS methodology for

plasma citrulline determination in multiple species. Anal Methods 2011;3:1759-

1768.

163. Dainiak N, Gent RN, Carr Z, Schneider R, Bader J, Buglova E, Chao N, Coleman N,

Ganser A, Gorin C, Hauer-Jensen M, Huff LA, Lillis-Hearne P, Maekawa K,

Nemhauser J, Powles R, Schunemann H, Shapiro A, Stenke L, Valverde N,

Weinstock D, White D, Albanese J, Meineke V: Literature review and global

consensus on management of acute radiation syndrome affecting non-hematopoietic

organ systems. Disaster Med Public Health Prep 2011;5:183-201. (PMCID:

PMC3638239)

164. Dainiak N, Gent RN, Carr Z, Schneider R, Bader J, Buglova E, Chao N, Coleman N,

Ganser A, Gorin C, Hauer-Jensen M, Huff LA, Lillis-Hearne P, Maekawa K,

Nemhauser J, Powles R, Schunemann H, Shapiro A, Stenke L, Valverde N,

Weinstock D, White D, Albanese J, Meineke V: First global consensus for evidence-

based management of the hematopoietic syndrome resulting from exposure to

ionizing radiation. Disaster Med Public Health Prep 2011;5:202-212. (PMCID:

PMC3643115)

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Hauer-Jensen

165. Berbee M, Fu Q, Boerma M, Kumar KS, Loose DS, Hauer-Jensen M: Mechanisms

underlying the radioprotective properties of γ-tocotrienol: comparative gene

expression profiling in tocol-treated endothelial cells. Genes Nutr 2012;7:75-81.

(PMCID: PMC3250525)

166. Berbee M, Hauer-Jensen M: Novel drugs to ameliorate gastro-intestinal normal

tissue radiation toxicity in clinical practice: what is emerging from the laboratory?

Curr Opin Support Palliat Care 2012;6:54-60. (PMCID: PMC3677768)

167. Nowak G, Bakajsova D, Hayes C, Hauer-Jensen M, Compadre CM: γ-tocotrienol

protects against mitochondrial dysfunction and renal cell death. J Pharmacol Exp

Ther 2012;340:330-338. (PMCID: PMC3263958)

168. Landes RD, Lensing SY, Kodell RL, Hauer-Jensen M: Statistical analysis of

survival data from radiation countermeasure experiments. Radiat Res 2012;177:546-

554. (PMCID: PMC3387733)

169. Biju PG, Garg S, Wang W, Choudhry MA, Kovacs EJ, Fink LM, Hauer-Jensen M:

Procalcitonin as a predictive biomarker for total body irradiation induced bacterial

load and lethality in mice. Shock 2012;38:170-176. (PMCID: PMC3399035)

170. Geiger H, Pawar SA, Kerschen EJ, Nattamai KJ, Hernandez I, Liang HP, Fernandez

JA, Cancelas JA, Ryan MA, Kustikova O, Schambach A, Fu Q, Wang J, Fink LM,

Petersen KU, Zhou D, Griffin JH, Baum C, Weiler H, Hauer-Jensen M:

Pharmacological targeting of the thrombomodulin – activated protein C pathway

mitigates radiation toxicity. Nature Med 2012;18:1123-1129. (PMCID:

PMC3491776)

171. Kulkarni SS, Cary LH, Gambles K, Hauer-Jensen M, Kumar KS, Ghosh SP:

Gamma-tocotrienol, a radiation prophylaxis agent, induces high levels of granulocyte

colonystimulating factor. Int Immunopharmacol 2012;14:495-503.

172. Sridharan V, Tripathi P, Sharma SK, Moros EG, Corry PM, Lieblong BJ, Kaschina E,

Unger T, Thone-Reineke C, Hauer-Jensen M, Boerma M: Cardiac inflammation

after local irradiation is influenced by the kallikrein-kinin system. Cancer Res

2012;72:4984-4992. (PMCID: PMC3463770)

173. Wang J, Kulkarni A, Chintala M, Fink LM, Hauer-Jensen M: Inhibition of protease-

activated receptor 1 ameliorates intestinal radiation mucositis in a preclinical rat

model. Int J Radiat Oncol Biol Phys 2013;85:208-214. (PMCID: PMC3462888)

174. Wu L, Shao L, Li M, Zheng J, Wang J, Feng W, Chang J, Wang Y,

Hauer-Jensen M, Zhou D: BMS-345541 sensitizes MCF-7 breast cancer cells to

ionizing radiation by selective inhibition of homologous recombinational repair of

DNA double-strand breaks. Radiat Res 2013;179:160-170. (PMCID: PMC3607209)

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Hauer-Jensen

175. Zheng J, Garg S, Wang J, Loose DS, Hauer-Jensen M: Laser capture microdissected

mucosa versus whole tissue specimens for assessment of radiation-induced dynamic

molecular and pathway changes in the small intestine. PLoS One

2013;8(1);e53711:1-11. (PMCID: PMC3544848)

176. Ghosh SP, Singh R, Chakraborty K, Dennis K, Kaur P, Kulkarni S, Pathak R, Kumar

KS, Hauer-Jensen M, Cheema AK: Metabolomic changes in gastrointestinal tissues

after whole body radiation in a murine model. Mol Biosyst 2013;9:723-731. (PMCID:

PMC3601576)

177. Ray S, Chakraborty K, Pessu RL, Hauer-Jensen M, Kumar KS, Ghosh SP:

Mobilization of progenitor cells into peripheral blood by gamma-tocotrienol: a

promising radiation countermeasure. Int Immunopharmacol 2013;15:557-564.

178. Sridharan V, Sharma SK, Moros EG, Corry PM, Tripathi P, Lieblong BJ, Guha C,

Hauer-Jensen M, Boerma M: Effects of radiation on the epidermal growth factor

receptor pathway in the heart. Int J Radiat Biol 2013;89:539-547. (PMCID:

PMC3700655)

179. Kulkarni S, Chakraborty K, Kumar S, Kao T, Hauer-Jensen M, Ghosh S:

Synergistic radioprotection by gamma-tocotrienol and pentoxifylline: Role of cAMP

signaling. ISRN Radiol 2013;390379:1-11. (PMCID: PMC4045513)

180. Boerma M, Wang J, Sridharan V, Herbert JM, Hauer-Jensen M: Pharmacological

induction of transforming growth factor-beta1 in rat models enhances radiation injury

in the intestine and the heart. PLoS One 2013;8(7):e70479. (PMCID: PMC3723823)

181. Wray J, Williamson E, Singh S, Wu Y, Cogle C, Weinstock D, Zhang Y, Lee SH,

Zhou D, Shou L, Hauer-Jensen M, Pathak R, Klimek V, Nickoloff J, Hromas R:

PARP1 is required for chromosomal translocations. Blood 2013;121(21):4359-65.

(PMCID: PMC3663429)

182. Sridharan V, Tripathi P, Sharma S, Corry PM, Moros EG, Singh A, Compadre CM,

Hauer-Jensen M, Boerma M: Effects of late administration of pentoxifylline and

tocotrienols in an image-guided rat model of localized heart irradiation. PLoS One

2013;8(7):e68762:1-13. (PMCID: PMC3718790)

183. Landes RD, Lensing SY, Kodell RL, Hauer-Jensen M: Practical advice on

calculating confidence intervals for radioprotection effects and reducing animal

numbers in radiation countermeasure experiments. Radiat Res 2013;180:567-574.

(PMCID: PMC3955841)

184. Burnett AF, Biju PG, Liu H, Hauer-Jensen M: Oral interleukin-11 as a

countermeasure to lethal total body irradiation in a murine model. Radiat Res

2013;180:595-602. (PMCID: PMC4030300)

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Hauer-Jensen

185. Palmer JL, Deburghgraeve CR, Bird MD, Chen MM, Hauer-Jensen M, and Kovacs

EJ: Combined radiation and burn injury results in exaggerated early pulmonary

inflammation. Rad Res 2013;180:276-283. (PMCID: PMC4011563)

186. Denham JW, Hauer-Jensen M: A neglected iatrogenic problem. Lancet

2013;382:2046-2047.

187. Suman S, Datta K, Chakraborty K, Kulkarni SS, Doiron K, Fornace AJ, Kumar KS,

Hauer-Jensen M, Ghosh SP: Gamma tocotrienol, a potent radioprotector,

preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell

survival. Food Chem Toxicol 2013;60:486-496.

188. Sharma S, Moros EG, Boerma M, Sridharan V, Han EY, Clarkson R,

Hauer-Jensen M, Corry PM: A novel technique for image-guided local heart

irradiation in the rat. Technol Cancer Res Treat 2014;13:594-603. (PMCID:

PMC3951712)

189. Spitz DR, Hauer-Jensen M: Ionizing radiation-induced responses: where free radical

chemistry meets redox biology and medicine. Antioxid Redox Signal 2014;20:1407-

1409. (PMCID: PMC3936498)

190. Pathak R, Pawar SA, Fu Q, Gupta PK, Berbee M, Garg S, Sridharan V, Wang W,

Biju PG, Krager KJ, Boerma M, Ghosh SP, Cheema AK, Hendrickson HP, Aykin-

Burns N, Hauer-Jensen M: Characterization of transgenic Gfrp knock-in mice:

Implications for tetrahydrobiopterin in modulation of normal tissue radiation

responses. Antioxid Redox Signal 2014;20:1436-1446. (PMCID: PMC3936502)

191. Sridharan V, Tripathi P, Sharma S, Moros EG, Zheng J, Hauer-Jensen M, Boerma

M: Roles of sensory nerves in the regulation of radiation-induced structural and

functional changes in the heart. Int J Radiat Oncol Biol Phys 2014;88:167-174.

(PMCID: PMC3868013)

192. Compadre CM, Singh A, Thakkar S, Zheng G, Breen PJ, Ghosh S, Kiaei M, Boerma

M, Vurghese KI, Gupta PK, Brown J, Biju PG, Thaden J, Deutz NE, Kumar KS,

Hauer-Jensen M: Molecular dynamics guided design of tocoflexol: a new

radioprotectant tocotrienol with enhanced bioavailability. Drug Dev Res 2014;75:10-

22. (PMCID: PMC4082686)

193. Garg S, Wang W, Biju PG, Boerma M, Wang J, Zhou D, Hauer-Jensen M: Bone

marrow transplantation helps restore the intestinal mucosal barrier after total body

irradiation in mice. Radiat Res 2014;181:229-239. (PMCID: PMC4038129)

194. Sridharan V, Aykin-Burns N, Tripathi P, Krager KJ, Sharma SK, Moros EG, Corry

PM, Nowak G, Hauer-Jensen M, Boerma M: Radiation-induced alterations in

mitochondria of the rat heart. Radiat Res 2014;181:324-334. (PMCID: PMC4029615)

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Hauer-Jensen

195. EBCTCG (Early Breast Cancer Trialists’ Collaborative Group), McGale P, Taylor C, Correa C, Cutter D, Duane F, Ewertz M, Gray R, Mannu G, Peto R, Whelan T, Wang

Y, Wang Z, Darby S: Effect of radiotherapy after mastectomy and axillary surgery on

10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual

patient data for 8135 women in 22 randomised trials. Lancet 2014;383:2127-2135.

196. Hauer-Jensen M, Denham JW, Andreyev JN: Radiation enteropathy – pathogenesis,

treatment, and prevention. Nature Rev Gastroenterol Hepatol 2014;11:470-479.

(PMCID: PMC4346191)

197. Biju PG, Gubrij I, Garg S, Gupta PK, Hauer-Jensen M, Burnett AF: Radiation

lethality potentiation in total body irradiated mice by a commonly prescribed proton

pump inhibitor, pantoprazole sodium. Int J Radiat Biol 2014;90:554-559. (PMCID:

PMC4378842)

198. Pawar SA, Shao L, Chang J, Wang W, Pathak R, Zhu X, Wang J, Hendrickson H,

Boerma M, Sterneck E, Zhou D, Hauer-Jensen M: C/EBP delta deficiency sensitizes

mice to ionizing radiation-induced hematopoietic and intestinal injury. PLoS One

2014;9(4):e93967. (PMCID: PMC3991713)

199. Cheema A, Pathak R, Zandkarimi F, Kaur P, Alkhalil L, Singh R, Zhong X, Ghosh S,

Aykin-Burns N, Hauer-Jensen M: Liver Metabolomics Reveals Increased Oxidative

Stress and Fibrogenic Potential in Gfrp Transgenic Mice in Response to Ionizing

Radiation. J Proteome Res 2014;13:3065-3074. (PMCID: PMC4053308)

200. Hauer-Jensen M: Toward development of interleukin-11 as a medical

countermeasure for use in radiological/nuclear emergencies. Dig Dis Sci

2014;59:1349-1351. (PMCID: PMC4071113)

201. Pathak R, Shao L, Chafekar SM, Feng W, Ponnappan U, Fink LM, Zhou D, Hauer-

Jensen M: IKKβ regulates endothelial thrombomodulin in a Klf2-dependent manner.

J Thromb Haemost 2014;12:1533-1544. (PMCID: PMC4163124)

202. You Y, Wen R, Pathak R, Li A, Li W, St. Clair D, Hauer-Jensen M, Zhou D, Liang

Y. Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell cycle

arrest and cell death through Rps3 pathway. Cell Death Dis 2014;5: e1493. (PMCID:

PMC4237263)

203. Wang J, Zheng J, Kulkarni A, Wang W, Garg S, Prather PL, Hauer-Jensen M:

Palmitoylethanolamide regulates development of intestinal radiation injury in a mast

cell dependent manner. Dig Dis Sci 2014;59:2693-2703. (PMCID: PMC4213290)

204. Pathak R, Cheema AK, Boca SM, Krager KJ, Hauer-Jensen M, Aykin-Burns N:

Modulation of radiation response by the tetrahydrobiopterin pathway. Antioxidants

2015;4:68-81. (PMCID: PMC4665563)

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Hauer-Jensen

205. Sridharan V, Tripathi P, Aykin-Burns N, Krager KJ, Sharma SK, Moros EG, Melnyk

SB, Pavliv O, Hauer-Jensen M, Boerma M: A tocotrienol-enriched formulation

protects against radiation-induced changes in cardiac mitochondria without modifying

late cardiac function or structure. Radiat Res 2015;183;357–366. (PMCID:

PMC4688041)

206. Pathak R, Shao L, Ghosh SP, Zhou D, Boerma M, Weiler H, Hauer-Jensen M:

Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and

hematopoietic cell recovery in irradiated mice. PLoS One 2015;10(4):e0122511.

(PMCID: PMC4393275)

207. Kodell RL, Haun RS, Siegel ER, Zhang C, Trammel AB, Hauer-Jensen M, Burnett

AF: Novel use of proteomic profiles in a convex-hull ensemble classifier to predict

gynecological cancer patients’ susceptibility to gastrointestinal mucositis as side

effect of radiation therapy. J Proteomics Bioinform 2015;7:149-154. * (PMCID:

PMC4587761)

208. Nzabarushimana E, Prior S, Miousse IR, Pathak R, Allen AR, Latendresse J, Olsen

RH, Raber J, Hauer-Jensen M, Nelson GA, Koturbash I: Combined exposure to

protons and (56)Fe leads to overexpression of Il13 and reactivation of repetitive

elements in the mouse lung. Life Sci Space Res 2015;7:1-8. * (PMCID:

PMC4641818)

209. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG), Coleman R, Powles T, Paterson A, Gnant M, Anderson S, Diel I, Gralow J, von Minclwitz G, Moebus V,

Bergh J, Pritchard KI, Bliss J, Cameron D, Evans V, Pan H. Peto R, Bradley R, Gray

R: Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of

individual patient data from randomised trials. Lancet 2015;386:1353-1361.

210. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG), Dowsett M, Forbes

JF, Bradley R, Ingle J, Aihara T, Bliss J, Boccardo F, Coates A, Coombes RC, Cuzick

J, Dubsky P, Gnant M, Kaufmann M, Kilburn L, Perrone F, Rea D, Thürlimann B,

van de Velde C, Pan H, Peto R, Davies C, Gray R: Aromatase inhibitors versus

tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials.

Lancet 2015;386:1341-1352.

211. Zheng J, Wang J, Pouliot M, Authier S, Zhou D, Loose DS, Hauer-Jensen M: Gene

expression profiling in non-human primate jejunum, ileum and colon after total-body

irradiation: a comparative study of segment-specific molecular and cellular

responses. BMC Genomics 2015;16:984 * (PMCID: PMC4654820)

212. Wu Y, Lee S-H, Williamson EA, Reinert BL, Jaiswal AS, Srinivasan G, Patel B,

Brantly A, Zhou D, Shao L, Pathak R, Hauer-Jensen M, Singh S, Kong K, Wu X,

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Hauer-Jensen

Cho JH, Xia F, Kim H-S, Beissbart T, Gaedcke J, Burma S, Nicoloff JA, Hromas R:

EEPD1 rescues stressed replication forks and maintains genome stability by

promoting end resection and homologous recombination repair. PLoS Genet

2015;11(12);e1005675. * (PMCID: PMC4684289)

213. Krager KJ, Pineda EN, Kharade SV, Kordsmeier M, Howard L, Breen PJ, Compadre

CM, Hauer-Jensen M, Aykin-Burns N: Tocotrienol-rich fraction from rice bran

demonstrates potent radiation protection activity. Evid Based Complement Alternat

Med 2015;148791. * (PMCID: PMC4573888)

214. Chang J, Feng W, Wang Y, Luo Y, Allen AR, Koturbash I, Turner J, Stewart B,

Raber J, Hauer-Jensen M, Zhou D, Shao L: Whole body proton irradiation causes

long-term damage to hematopoietic stem cells in mice. Radiat Res 2015;183:240-248.

(PMCID: PMC4992474)

215. Kordsmeier M, Howard LR, Brownmiller C, Proctor A, Hauer-Jensen M: Isolation

of gamma and delta tocotrienols from rice bran oil deodorizer distillate using flash

chromatography. J Am Oil Chem Soc 2015;92:1243-1252. (PMCID: PMC4573888)

216. Pathak R, Hauer-Jensen M: Particle beam may have higher effectiveness in treating

chemoresistant cancers than low-LET photon beam therapy. Res Rev J Pharm Pharm

Sci 2015;4:1-2. * (PMCID: PMC4712956)

217. Boerma M, Nelson GA, Sridharan V, Mao XW, Koturbash I, Hauer-Jensen M:

Space radiation and cardiovascular disease risk. World J Cardiol 2015;7:882-888. *

(PMCID: PMC4691814)

218. Miousse IR, Chalbot MG, Pathak R, Lu X, Nzabanushimana E, Krager K, Aykin-

Burns N, Hauer-Jensen M, Demokritou P, Kavouras IG, Koturbash, I: In vitro

toxicity and epigenotoxicity of different types of ambient particulate matter. Toxicol

Sci 2015;148:473-487. * (PMCID: PMC5009441)

219. Wang J, Shao L, Hendrickson HP, Liu L, Chang J, Luo Y, Seng J, Pouliot M, Authier

S, Zhou D, Allaben W, Hauer-Jensen M: Total body irradiation in the

‘hematopoietic’ dose range induces substantial intestinal injury in non-human

primates. Radiat Res 2015;184:545-553. * (PMID: 26495870

220. Garg S, Zheng J, Wang J, Authier S, Pouliot M, Hauer-Jensen M: Segmental

differences in radiation-induced alterations of tight junction-related proteins in non-

human primate jejunum, ileum, and colon. Radiat Res 2016;185:50-59. * (PMCID:

PMC4720531)

221. Chang J, Wang W, Shao L, Feng W, Laberge R-M, Demaria M, Campisi J, Ding S,

Janakiraman K, Sharpless N, Luo Y, Wang X, Aykin-Burns N, Krager K, Ponnappan

U, Hauer-Jensen M, Meng A, Zhou D: Clearance of senescent cells by ABT263

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Hauer-Jensen

rejuvenates aged hematopoietic stem cells in mice. Nature Med 2016;22:78-83. *

(PMCID: PMC4762215)

222. Singh VK, Newman VL, Romaine PL, Hauer-Jensen M, Pollard HB: Use of

biomarkers for assessing radiation injury and efficacy of countermeasures. Expert

Review Mol Diagn 2016:16:65-81. (PMCID: PMC4732464)

223. Singh VK, Kulkarni S, Fatanmi OO, Wise SY, Newman VL, Romaine PL,

Hendrickson H, Gulani J, Ghosh S, Kumar KS, Hauer-Jensen M: Radioprotective

efficacy of gamma-tocotrienol in nonhuman primates. Radiat Res 2016;185:285-298.

(PMID: 26930378)

224. Koturbash I, Miousse IR, Sridharan V, Nzabarushimana E, Melnyk SB, Pavliv O,

Hauer-Jensen M, Nelson G, Boerma M: Radiation-induced changes in DNA

methylation of repetitive elements in the mouse heart. Mutat Res 2016;787:43-53.

(PMCID: PMC4828271)

225. Ramadan SS, Sridharan V, Koturbash I, Miousse IR, Hauer-Jensen M, Nelson GA,

Boerma M: A priming dose of protons alters the early cardiac cellular and molecular

response to (56)Fe irradiation. Life Sci Space Res 2016;8:8-13. (PMCID:

PMC4782196)

226. Ghosh SP, Pathak R, Kumar P, Biswas S, Bhattacharyya S, Kumar VP, Hauer-

Jensen M, Biswas R: Gamma tocotrienol modulates radiation-induced microRNA

expression in mouse spleen. Radiat Res 2016;185:485-495. (PMCID: PMC4893953)

227. Singh VK, Hauer-Jensen M: Gamma-Tocotrienol as a promising countermeasure for

acute radiation syndrome: current status. Int J Mol Sci 2016;17:E663. * (PMCID:

PMC4881489)

228. Liu YL, Yan Y, Webster C, Shao L, Lensing SY, Ni H, Feng W, Colorado N, Pathak

R, Xiang Z, Hauer-Jensen M, Li S, Zhou D, Emanuel PD: Timing of the loss of

PTEN protein determines disease severity in a mouse model of myeloid malignancy.

Blood 2016;127:1912-1922. (PMCID: PMC4832508)

229. Byrum, SD, Burdine MS, Orr L, Moreland L, Authier S, Pouliot M, Hauer-Jensen

M, Tackett AJ: A quantitative proteomic analysis of urine from gamma-irradiated

non-human primates. J Protemoics Bioinform 2016;9(Suppl 10):005. (PMCID:

PMC4780756)

230. Chang J, Luo Y, Wang Y, Pathak R, Sridharan V, Jones T, Mao X, Nelson G,

Boerma M, Hauer-Jensen M, Zhou D, Shao L: Low Doses of Oxygen Ion Irradiation

Cause Acute Damage to Hematopoietic Cells in Mice. PLoS ONE

2016;11(7):e0158097. * (PMCID: PMC4930193)

231. Prior S, Miousse IR, Nzabarushimana E, Pathak R, Skinner CM, Kutanzi KR, Allen

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Hauer-Jensen

AR, Raber J, Tackett A, Hauer-Jensen M, Nelson GA, Koturbash I: Densely

ionizing radiation affects DNA methylation of selective LINE-1 elements. Environ

Res 2016;150:470-81. * (PMCID: PMC5003736)

232. Bujold K, Hauer-Jensen M, Donini O, Rumage A, Hartman D, Hendrickson HP,

Stamatopoulos J, Naraghi H, Puliot M, Ascah A, Sebastian M, Pugsley MK, Wong K,

Authier S: Citrulline as a biomarker for gastrointestinal-acute radiation syndrome:

species differences and experimental condition effects. Radiat Res 2016;186:71–78. *

(PMCID: PMC4976929)

233. Liu X, Gujarathi S, Zhang X, Shao L, Boerma M, Compadre CM, Crooks PA,

Hauer-Jensen M, Zhou D, Zheng G: Synthesis of (2R,8′S,3′E,11′E)-δ-tocodienol, a

tocoflexol family member designed to have a superior pharmacokinetic profile than δ-

tocotrienol. Tetrahedron 2016;72:4001-4006. * (PMCID: PMC5070675)

234. Pathak R, Wang J, Garg S, Aykin-Burns N, Petersen KU, Hauer-Jensen M:

Recombinant thrombomodulin (Solulin) ameliorates early intestinal radiation toxicity

in a preclinical rat model. Radiat Res 2016;186:112-120. * (PMCID: PMC4995594)

235. Banerjee S, Aykin-Burns N, Krager K, Shah SK, Melnyk SB, Hauer-Jensen M,

Pawar SA: Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative

stress and mitochondrial dysfunction. Free Radic Biol Med 2016;99:296-307. *

(PMCID: PMC5673253)

236. Pathak R, Bachri A, Ghosh SP, Koturbash I, Boerma M, Binz RK, Sawyer JR,

Hauer-Jensen M: The vitamin E analog gamma-tocotrienol (GT3) suppresses

radiation-induced cytogenetic damage. Pharm Res 2016;33:2117-2125. * (PMCID:

PMC4967083)

237. Singh VK, Thrall KD, Hauer-Jensen M: Minipigs as models in drug discovery.

Expert Opin Drug Discov 2016;11:1131-1134. (PMID: 27546211)

238. Pathak R, Ghosh SP, Zhou D, Hauer-Jensen M: The Vitamin E Analog Gamma

Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial

Thrombomodulin (TM). Int J Mol Sci 2016;17:E1937. * (PMCID: PMC5133932)

239. Miousse IR, Koturbash I, Chalbot MC, Hauer-Jensen M, Kavouras IG, Pathak R: ,

Analysis of the ambient particulate matter-induced chromosomal aberrations using an

in vitro system. J Vis Exp 2016;118:e54969, doi:10.3791/54969. * (PMCID:

PMC5226431)

240. Boerma M, Sridharan V, Mao XW, Nelson GA, Cheema AK, Koturbash I, Singh SP,

Tackett AJ, Hauer-Jensen M: Effects of ionizing radiation on the heart. Mutat Res

Rev 2016;770(Pt B):319-327. * (PMCID: PMC5144922)

241. Hauer-Jensen M, Laderoute KR, Phillips MH: The New Academic Terminology:

- 38 -

Hauer-Jensen

Adapting our Mission Statement and Terminology to Reflect the Contemporary Core

Values of Academic Medical Centers. Nutr Food Sci Int J 2016;2:555576. DOI:

10.19080/NFSIJ.2016.02.555576

242. Byrum SD, Burdine MS, Orr L, Mackintosh SG, Authier S, Pouliot M, Hauer-

Jensen M, Tackett AJ: Time- and radiation-dose dependent changes in the plasma

proteome after total body irradiation of non-human primates: implications for

biomarker selection. PLoS ONE 2017;12(3):e0174771. * (PMCID: PMC5370149)

243. Pathak R, Koturbash I, Hauer-Jensen M: Detection of inter-chromosomal stable

aberrations by multiple fluorescence in situ hybridization (mFISH) and spectral

karyotyping (SKY) in irradiated mice. J Vis Exp 2017;119:e55162,

doi:10.3791/55162. * (PMCID: PMC5352253)

244. Chang J, Feng W, Wang Y, Allen AR, Turner J, Stewart B, Raber J, Hauer-Jensen

M, Zhou D, Shao L: 28Si total body irradiation injures bone marrow hematopoietic

stem cells via induction of cellular apoptosis. Life Sci Space Res 2017;13:39-44. *

(PMID: 28554508)

245. Miousse IR, Tobacyk J, Melnyk S, James SJ, Cheema AK, Boerma M, Hauer-

Jensen M, Koturbash I: One-carbon metabolism and ionizing radiation: a

multifaceted interaction. Biomol Concepts 2017;8:83-92. * (PMID: 28574375)

246. Miousse IR, Chang J, Shao L, Pathak R, Nzabarushimana E, Kutanzi KR, Landes

RD, Tackett AJ, Hauer-Jensen M, Zhou D, Koturbash I: Inter-Strain Differences in

LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to

Exposure to Ionizing Radiation. Int J Mol Sci 2017;18:E1430. * (PMCID:

PMC5535921)

247. Seawright JW, Samman Y, Sridharan V, Mao XW, Cao M, Singh P, Melnyk S,

Koturbash I, Nelson GA, Hauer-Jensen M, Boerma M: Effects of low-dose rate γ-

irradiation combined with simulated microgravity on markers of oxidative stress,

DNA methylation potential, and remodeling in the mouse heart. PLoS ONE

2017;12(7):e0180594. * (PMCID: PMC5498037)

248. Pan J, Li D, Xu Y, Zhang J, Wang Y, Chen M, Lin S, Huang L, Chung EJ, Citrin DE,

Wang Y, Hauer-Jensen M, Zhou D, Meng A: Inhibition of Bcl-2/xl with ABT-263

selectively kills senescent type II pneumocytes and reverses persistent pulmonary

fibrosis induced by ionizing radiation in mice. Int J Radiat Oncol Biol Phys

2017;99:353-361. * (PMID: 28479002)

249. Wang J, Pathak R, Garg S, Hauer-Jensen M: Fibrinogen deficiency suppresses the

development of early and delayed radiation enteropathy. World J Gastroenterol

2017;23:4701-4711. * (PMCID: PMC5514635)

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Hauer-Jensen

250. Wang Y, Chang J, Li X, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G,

Boerma M, Hauer-Jensen M, Zhou D, Shao L: Low doses of oxygen ion irradiation

cause long-term damage to bone marrow hematopoietic progenitor and stem cells in

mice. PLoS ONE 2017;12(2):e0189466. * (PMCID: PMC5726652)

251. Miousse IR, Pathak R, Garg S, Skinner CM, Melnyk S, Pavliv O, Hendrickson H,

Landes RD, Lumen A, Tackett AJ, Deutz NEP, Hauer-Jensen M, Koturbash I:

Short-term dietary methionine supplementation affects one-carbon metabolism and

DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier

function, gene expression and histomorphology. Genes Nutr 2017;12:22. * (PMCID:

PMC5588631)

252. Casero D, Gill K, Sridharan V, Koturbash I, Nelson G, Hauer-Jensen M, Boerma M,

Braun J, Cheema AK: Space-type radiation induces multimodal responses in the

mouse gut microbiome and metabolome. Microbiome 2017;5:105. * (PMCID:

PMC5563039)

253. Pan H, Gray R, Braybrooke J, Davies C, Taylor C, McGale P, Peto R, Pritchard KI,

Bergh J, Dowsett M, Hayes DF; EBCTCG: 20-year risks of breast-cancer recurrence

after stopping endocrine therapy at 5 years. N Engl J Med 2017;377:1836-1846.

254. Chang J, Wang Y, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M,

Hauer-Jensen M, Zhou D, Shao L: Whole body proton irradiation causes acute

damage to bone marrow hematopoietic progenitor and stem cells in mice. Int J Radiat

Biol 2017;93;1312-1320. * (PMID: 28782442)

255. Bose C, Awasthi S, Sharma R, Beneš H, Hauer-Jensen M, Boerma M, Singh S P:

Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its

cardiotoxicity in a breast cancer model. PLoS ONE 2018;13(3):e0193918. * (PMCID:

PMC5843244)

256. Banerjee S, Shah SK, Melnyk SB, Pathak R, Hauer-Jensen M, Pawar SA: Cebpd is

essential for gamma-tocotrienol mediated protection against radiation-induced

hematopoietic and intestinal injury. Antioxidants 2018;7:E55. * (PMCID:

PMC5946121)

257. Luo Y, Shao L, Chang J, Feng W, Liu YL, Cottler-Fox MH, Emanuel PD, Hauer-

Jensen M, Bernstein ID, Liu L, Chen X, Zhou J, Murray PJ, Zhou D: M1 and M2

macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo

expansion. Blood Adv 2018;2:859-870. * (PMCID: PMC5916005)

258. Cheema AK, Byrum SD, Sharma NK, Altadill T, Kumar VP, Biswas S, Balgley BM,

Hauer-Jensen M, Tackett AJ, Ghosh SP: Proteomic changes in mouse spleen after

radiation-induced injury and its modulation by gamma-tocotrienol. Radiat Res

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Hauer-Jensen

2018:190:449-463. * (PMCID: PMC6297072)

259. Aykin-Burns N, Pathak R, Boerma M, Kim T, Hauer-Jensen M: Utilization of

Vitamin E analogs to protect normal tissues while enhancing antitumor effects. Semin

Radiat Oncol 2019;29:55-61. * (PMCID: PMC6309800)

260. Seawright JW, Sridharan V, Landes RD, Cao M, Singh P, Koturbash I, Mao XW,

Miousse IR, Singh SP, Nelson GA, Hauer-Jensen M, Boerma M: Effects of low-

dose oxygen ions and protons on cardiac function and structure in male C57BL/6J

mice. Life Sci Space Res 2019;20:72-84. * (PMCID: PMC6391741)

261. Landes RD, Lensing SY, Hauer-Jensen M: Interval estimators of relative potency in

toxicology and radiation countermeasure studies: comparing methods and

experimental designs. J Biopharm Stat 2019;29:348-358. * (PMCID: PMC6450382)

262. Pathak R, Shah SK, Hauer-Jensen M: Therapeutic potential of natural plant products

and their metabolites in preventing radiation enteropathy resulting from abdominal or

pelvic irradiation. Int J Radiat Biol 2019; 95:493-505. * (PMCID: PMC6461490)

263. Garg S, Sadhukhan R, Banerjee S, Savenka AV, Basnakian AG, McHargue V, Wang

J, Pawar SA, Ghosh SP, Ware J, Hauer-Jensen M, Pathak R: Gamma-tocotrienol

protects the intestine from radiation potentially by accelerating mesenchymal immune

cell recovery. Antioxidants 2019;8:E57 * (PMID: 30845647)

264. Pathak R, Kumar VP, Hauer-Jensen M, Ghosh SP: Enhanced survival in mice

exposed to ionizing radiation by combination of gamma-tocotrienol and simvastatin.

Mil Med 2019;184: 644-651. (PMID: 30901461)

265. Binz RL, Tian E, Sadhukhan R, Zhou D, Hauer-Jensen M, Pathak R: Identification

of novel breakpoints for locus- and region-specific translocations in 293 cells by

molecular cytogenetics before and after irradiation. Sci Rep 2019;9:10554. (PMCID;

PMC6646394). *

266. Miousse IR, Skinner CM, Sridharan V, Seawright JW, Singh P, Landes RD, Cheema

AK, Hauer-Jensen M, Boerma M, Koturbash I: Changes in one-carbon metabolism

and DNA methylation in the hearts of mice exposed to space environment-relevant

doses of oxygen ions (16O). Life Sci Space Res 2019;22:8-15. (PMCID:

PMC6703167) *

267. Banerjee S, Fu Q, Shah SK, Melnyk SB, Sterneck E, Hauer-Jensen M, Pawar SA:

C/EBPδ protects from radiation-induced intestinal injury and sepsis by suppression of

inflammatory and nitrosative stress. Sci Rep 2019;9:13953. (PMID: 31562350)

268. Ewing LE, Miousse IR, Pathak R, Skinner CM, Kosanke S, Boerma M, Hauer-

Jensen M, Koturbash I: NZO/HlLtJ as a novel model for the studies on the role of

metabolic syndrome in acute radiation toxicity. Int J Radiat Biol, in press. * (PMID:

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Hauer-Jensen

30561233)

269. Miousse IR, Ewing LE, Skinner CM, Pathak R, Garg S, Kutanzi KR, Melnyk S,

Hauer-Jensen M, Koturbash I: Methionine dietary supplementation potentiates

ionizing radiation-induced gastrointestinal syndrome. Am J Physiol Gastrointest

Liver Physiol 2020;318:G439-G450. (PMID: 31961718) *

MONOGRAPHS, BOOKS, BOOK CHAPTERS

270. Hauer-Jensen M. Late Radiation Injury of the Small Intestine. University of Oslo,

Lobo Press, Oslo. 1988. (Doctoral Thesis.)

271. Hauer-Jensen M. Chapter 2. Late Radiation Injury of the Small Intestine. In: New

Aspects of Surgical Pathophysiology. Eds. Aasen AO, Risberg B. Harwood

Academic Publishers, London, 1990, pp. 399-422.

272. Lang NP, Broadwater JR, Klimberg S, Hauer-Jensen M, Baker GF, Westbrook KC.

Chapter 28. Malignant Diseases of the Skin. In: Essentials of General Surgery, 2nd

Edition. Eds. Lawrence P, Bell RM, Dayton MT. Williams & Wilkins, Baltimore

1992, pp. 359-374.

273. Hauer-Jensen M, Poulakos L. Chapter 35. Experimental Radiation Injuries of the

Gastrointestinal Tract. In: Essentials of Experimental Surgery. Gastroenterology. Eds.

Lindkaer Jensen S, Gregersen H, Moody FG, Shokouh-Amiri MH. Harwood

Academic Publishers, London 1996, pp. 35/1-35/21.

274. Hauer-Jensen M, Wang J, Denham JW: Chapter 5. Mechanisms and Modification of

the Radiation Response of Gastrointestinal Organs. In: Biological Modification of

Radiation Response. Eds. Milas L, Ang KK, Nieder C. Springer Verlag, Heidelberg

2003, pp. 49-72.

275. Wang J, Mehta JL, Fink LM, Hauer-Jensen M: Chapter 12. Anticoagulant Effects of

Statins. In: Statins – Understanding Clinical Use. Ed. Mehta JL. Saunders-Elsevier,

Philadelphia, PA, 2004, pp. 233-256.

276. Hauer-Jensen M, Kumar KS, Wang J, Berbee M, Fu Q, Boerma M: Chapter 2.

Intestinal toxicity in radiation- and combined injury: significance, mechanisms, and

countermeasures. In: Global Terrorism Issues and Developments. Ed. Larche RA.

Nova Science Publishers, Hauppauge, NY, 2008, pp. 61-100.

277. Boerma M, Wang J, Corbley MJ, Hauer-Jensen M: Chapter 36. Targeting TGF-β as a Strategy to Ameliorate Intestinal Side Effects of Radiation Therapy. In:

Transforming Growth Factor-beta in Cancer Therapy. Ed. Jakowlew S. In: Methods

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Hauer-Jensen

in Molecular Biology: Cancer Drug Discovery and Development, series ed. Teicher

BA. Humana Press, Totowa, NJ, 2008, pp. 589-608.

278. Boerma M, Brower GL, Kennedy RH, Joseph J, Wang J, Levick SP, Janicki JS,

Hauer-Jensen M: Chapter 1. Novel insight into the role of mast cells in cardiac

disease. In: Mast Cells: Roles, Interactions and Disorders. Eds. Jung JF, Scholz LT.

Nova Science Publishers, Hauppauge, NY, 2008, pp. 13-40.

279. Levick SP, Boerma M, Hauer-Jensen M, Brower GL, Janicki JS: Chapter 2.

Functional role of mast cells in the pathophysiology of cardiovascular disease. In:

Mast Cells: Roles, Interactions and Disorders. Eds. Jung JF, Scholz LT. Nova Science

Publishers, Hauppauge, NY, 2008, pp. 41-76.

280. Ghosh SP, Hauer-Jensen M, Kumar KS: Chapter 7. Chemistry of tocotrienols. In:

Tocotrienols – Vitamin E beyond Tocopherols. Ed. Watson RR, Preedy VR. CRC

Press, Boca Raton, FL, 2009, pp. 85-96.

281. Kumar KS, Ghosh SP, Hauer-Jensen M: Chapter 27. Gamma-tocotrienol: potential

as a countermeasure against radiological threat. In: Tocotrienols – Vitamin E beyond

Tocopherols. Ed. Watson RR, Preedy VR. CRC Press, Boca Raton, FL, 2009,

pp. 379-398.

282. Hauer-Jensen M, Wang J, Boerma M: Chapter 5. Mast cells and tissue remodeling.

In: Mast Cells and Cardiovascular Disease. Ed. Joseph J. Nova Science Publishers,

Hauppauge, NY, 2010, pp. 89-109.

283. Boerma M, Kennedy RH, Wang J, Hauer-Jensen M: Chapter 9. Role of mast cells in

radiation-induced heart disease. In: Mast Cells and Cardiovascular Disease. Ed.

Joseph J. Nova Science Publishers, Hauppauge, NY, 2010, pp. 175-192.

284. Hauer-Jensen M, Denham JW, Hovdenak N, Kumar KS: Chapter 38. Small bowel

and colon. In: Human Radiation Injury. Ed. Shrieve DC, Loeffler JS. Lippincott

Williams & Wilkins, Philadelphia, PA, 2011, pp. 421-440.

285. Whitnall MH, Srinivasan V, Landauer MR, Singh VK, Miller AC, Xiao M, Grace

MB, Kumar KS, Hauer-Jensen M, Ghosh SO, Mog SR, Chang CM, Kao TC,

Pellmar TC: Chapter 9, Prophylaxis and Therapy. In: NATO/RTO Technical Report,

Radiation Bioeffects and Countermeasures. Ed. Blakely WF, Duffy F, Edwards K,

Janiak MK. NATO/PFP Publications, Neuilly-sur-Seine, France, 2011, pp. 9-1–9-22.

286. Berbee M, Fu Q, Kumar, KS, Hauer-Jensen M: Chapter 7. Tetrahydrobiopterin and

endothelial nitric oxide synthase: Implications for radiation-induced endothelial

dysfunction and normal tissue radiation injury. In: Oxidative Stress in Applied Basic

Research and Clinical Practice: Cancer. Ed. Spitz DR, Dornfeld KJ, Krishnan K, Gius

D. Humana Press, Springer Science, New York, NY, 2012, pp. 131-147.

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Hauer-Jensen

287. Kumar KS, Kiang JG, Whitnall MH, Hauer-Jensen M: Chapter 11, Perspectives in

radiological and nuclear countermeasures. In: Textbooks of Military Medicine:

Medical Consequences of Radiological and Nuclear Weapons. TMM Publications,

Office of the Surgeon General. Falls Church, VA, 2012, pp. 239-266.

288. Stewart FA, Akleyev AV, Hauer-Jensen M, Hendry JH, Kleiman NJ, MacVittie TJ,

Aleman BM, Edgar AB, Mabuchi K, Muirhead CR, Shore RE, Wallace WH: ICRP

statement on tissue reactions. Early and late effects of radiation in normal tissues and

organs: threshold doses for tissue reactions in a radiation protection context. Ann

ICRP 2012;41(1/2):1-322. (PMID: 2292537)

289. Singh A, Breen PJ, Ghosh S, Kumar KS, Varughese KI, Crooks PA, Hauer-Jensen

M, Compadre CM: Chapter 26. Structural modification of tocotrienols to improve

bioavailability. In: Tocotrienols – Vitamin E beyond Tocopherols, 2nd edition. Ed.

Tan B, Watson RR, Preedy VR. CRC Press, Boca Raton, FL, 2013, pp. 359-370.

PRINTED MEETING ABSTRACTS & LETTERS

More than 300 printed abstracts in proceedings from regional, national, and international

meetings and letters in scientific journals.