httpwwwnesacsorg

April 2018 Vol XCVI No8

NORTHEASTERN SECTION bull AMERICAN CHEMIC

ALSO

CIET

Y

FOUNDED 1898

NESACS

MonthlyMeetingEsselen Award Meeting atHarvardJennifer A Doudna to Receive2018 Award

2018 NESACSCandidates forElection

In Memory ofTed TaylorBy Michael P Filosa

NESACS atFenway ParkMay 14 2018 710 pmTickets Available

2 The Nucleus April 2018

A brief history of the AwardIn 1985 an inquiry was made as towhether the Section would wish tohonor another former leader of theNortheastern Section The Esselen fam-ily proposed to donate a sum of moneyto provide for an award in the memoryof Gustavus John Esselen II Chairmanin 1922 and 1923 and a member of theACS Board of Directors for many yearsIn 1948 Dr Esselen received a specialaward the James Flack Norris HonorScroll ldquoas the person who has donemost to advance the interests of theNortheastern Sectionrdquo A committeeconsisting of William O Foye TrumanS Light Arthur S Obermayer andMyron S Simon Section Chairmanmet with Esselenrsquos son Gustavus J Es-selen III and recommended to theBoard of Directors that the Section ac-cept the offer which it did The commit-tee and Mr Esselen agreed that theaward should not be in a specific fieldof chemistry but instead should have thespecial purpose of emphasizing the pos-itive values of chemistry to mankind Inlight of the climate of the day with the

disaster of Bhopal on every chemistrsquosmind and the public receiving nothingbut negative stories about chemistryfrom the media this was to be a smallstep toward establishing a balance

Mr Esselen proposed to add abronze medal to the monetary award Aprominent sculptor from Newton Mas-sachusetts Lloyd Lillie was selected toprepare the design which was then ap-proved by members of the Esselen fam-ily The fact that Dr Esselen had donemuch work in plastics during his careerled his son to propose that the bronzemedal be imbedded in a block of clearplastic which was done to give a verydistinctive addition to the ceremonialpresentation

The first presentation of the Gus-tavus John Esselen Award for Chemistryin the Public Interest was made in 1987to F Sherwood Rowland and Mario JMolina for their work on the chemicalprocesses which were destroying thestratospheric ozone layer explaining theformation of the Antarctic Ozone HoleSince then the award has been given tochemists in several fields of chemistry

and has become a much coveted prize-By Myron S Simon assisted by PhyllisA Brauner Arno Heyn and Arthur SObermayer with suggestions from Ed-ward R Atkinson ldquoThe Last QuarterCentury Part Irdquo The Nucleus North-eastern Section of the American Chem-ical Society Inc February 1998 pp17-18

A brief biographyGustavus John Esselen II was born inRoxbury Massachusetts June 30 1888the son of Gustavus J and JoannaBlyleven Esselen All of his higher edu-cation was obtained at Harvard Univer-sity where he was awarded the AB(magna cum laude) in chemistry in 1909and a doctorate in 1912 In that sameyear he married Henrietta W Locke whowith three children survived him at thetime of his death on Oct 22 1952

Until 1921 he was a member of theresearch staff of General Electric Co inLynn and then of Arthur D Little Incof Cambridge MA At the latter firm hewas associated with Little and WallaceMurray in the fabrication of a ldquosilkrdquopurse from reconstituted collagen inturn derived from a sowrsquos ear In 1930he founded Gustavus J Esselen Incwhich subsequently became Esselen Re-search Corporation and then followinga merger Esselen Research Division ofUnited States Testing Co Inc Duringthis period he was involved in solving avariety of problems submitted by indus-trial clients Among these was the devel-opment of anhydride curing agents forepoxy resins and poly(vinylbutyral) asan improved material for safety glassboth of which enjoyed considerablecommercial success More than 40 USpatents were issued as a result of his re-search efforts

Esselen was a member of theAmerican Chemical Society for 43years during which time his outstandingservices to the society and the profes-sion of chemistry were recognized andhonored not only in his native NewEngland but throughout the UnitedStates He was twice chairman of theNortheastern Section ACS (1922-23)

Gustavus John Esselen II

continued on page 9

2 The Nucleus April 2018

A brief history of the AwardIn 1985 an inquiry was made as towhether the Section would wish tohonor another former leader of theNortheastern Section The Esselen fam-ily proposed to donate a sum of moneyto provide for an award in the memoryof Gustavus John Esselen II Chairmanin 1922 and 1923 and a member of theACS Board of Directors for many yearsIn 1948 Dr Esselen received a specialaward the James Flack Norris HonorScroll ldquoas the person who has donemost to advance the interests of theNortheastern Sectionrdquo A committeeconsisting of William O Foye TrumanS Light Arthur S Obermayer andMyron S Simon Section Chairmanmet with Esselenrsquos son Gustavus J Es-selen III and recommended to theBoard of Directors that the Section ac-cept the offer which it did The commit-tee and Mr Esselen agreed that theaward should not be in a specific fieldof chemistry but instead should have thespecial purpose of emphasizing the pos-itive values of chemistry to mankind Inlight of the climate of the day with the

disaster of Bhopal on every chemistrsquosmind and the public receiving nothingbut negative stories about chemistryfrom the media this was to be a smallstep toward establishing a balance

Mr Esselen proposed to add abronze medal to the monetary award Aprominent sculptor from Newton Mas-sachusetts Lloyd Lillie was selected toprepare the design which was then ap-proved by members of the Esselen fam-ily The fact that Dr Esselen had donemuch work in plastics during his careerled his son to propose that the bronzemedal be imbedded in a block of clearplastic which was done to give a verydistinctive addition to the ceremonialpresentation

The first presentation of the Gus-tavus John Esselen Award for Chemistryin the Public Interest was made in 1987to F Sherwood Rowland and Mario JMolina for their work on the chemicalprocesses which were destroying thestratospheric ozone layer explaining theformation of the Antarctic Ozone HoleSince then the award has been given tochemists in several fields of chemistry

and has become a much coveted prize-By Myron S Simon assisted by PhyllisA Brauner Arno Heyn and Arthur SObermayer with suggestions from Ed-ward R Atkinson ldquoThe Last QuarterCentury Part Irdquo The Nucleus North-eastern Section of the American Chem-ical Society Inc February 1998 pp17-18

A brief biographyGustavus John Esselen II was born inRoxbury Massachusetts June 30 1888the son of Gustavus J and JoannaBlyleven Esselen All of his higher edu-cation was obtained at Harvard Univer-sity where he was awarded the AB(magna cum laude) in chemistry in 1909and a doctorate in 1912 In that sameyear he married Henrietta W Locke whowith three children survived him at thetime of his death on Oct 22 1952

Until 1921 he was a member of theresearch staff of General Electric Co inLynn and then of Arthur D Little Incof Cambridge MA At the latter firm hewas associated with Little and WallaceMurray in the fabrication of a ldquosilkrdquopurse from reconstituted collagen inturn derived from a sowrsquos ear In 1930he founded Gustavus J Esselen Incwhich subsequently became Esselen Re-search Corporation and then followinga merger Esselen Research Division ofUnited States Testing Co Inc Duringthis period he was involved in solving avariety of problems submitted by indus-trial clients Among these was the devel-opment of anhydride curing agents forepoxy resins and poly(vinylbutyral) asan improved material for safety glassboth of which enjoyed considerablecommercial success More than 40 USpatents were issued as a result of his re-search efforts

Esselen was a member of theAmerican Chemical Society for 43years during which time his outstandingservices to the society and the profes-sion of chemistry were recognized andhonored not only in his native NewEngland but throughout the UnitedStates He was twice chairman of theNortheastern Section ACS (1922-23)

Gustavus John Esselen II

continued on page 9

The Nucleus April 2018 3

The Nucleus is published monthly except June and August by the Northeastern Section of the AmericanChemical Society Inc Forms close for advertising on the 1st of the month of the preceding issue Textmust be received by the editor six weeks before the date of issueEditor Michael P Filosa PhD 18 Tamarack Road Medfield MA 02052 Email

mpf1952gmailcom Tel 508-843-9070Associate Editors Myron S Simon 60 Seminary Ave apt 272 Auburndale MA 02466

Morton Z Hoffman 23 Williams Rd Norton MA 02766Board of Publications James Phillips (Chair) Mary Mahaney Ajay Purohit Ken Drew Katherine

LeeBusiness Manager Vacant contact Michael Filosa at mpf1952gmailcomAdvertising Manager Vacant contact Michael Filosa at mpf1952gmailcomCalendar Coordinator Xavier Herault Email xheraultoutlookcomPhotographers Morton Hoffman and James PhillipsProofreaders Donald O Rickter Morton Z HoffmanWebmaster Roy Hagen Email webmasternesacsorgCopyright 2018 Northeastern Section of the American Chemical Society Inc

The Northeastern Section of the American-Chemical Society IncOffice Anna Singer 12 Corcoran RoadBurlington MA 01803(Voice or FAX) (781)272-1966e-mail secretarynesacsorgNESACS HomepagehttpwwwNESACSorgOfficers 2018ChairMindy Levine35 Cottage StSharon MA 02067-2130(516)697-9688mindylevinegmailcomChair-ElectAndrew ScholteSanofiWaltham MA617-459-5145ascholtegmailcomImmediate Past ChairLeland L Johnson JrEuretosCambridge MA+16173046474lelandjohnsoneuretoscomSecretaryMichael SingerMilliporeSigma3 Strathmore Rd Natick MA 01760(774)290-1391 MichaelsingersialcomTreasurerAshis Saha67 Bow StArlington MA 02474-2744(978)212-5462sahaashish1909gmailcomAuditorPatrick GordonArchivistKen MattesTrusteesPeter C Meltzer Dorothy Phillips Ruth TannerDirectors-at-LargeDavid Harris June Lum Michael P Filosa John Neumeyer James U Piper Ralph ScannellCouncilorsAlternate CouncilorsTerm Ends 12312018Katherine Lee Chris MoretonCatherine E Costello Ajay PurohitRuth Tanner June LumKenneth Mattes Malika Jeffries-EL Jackie OrsquoNeil Joshua SacherTerm Ends 12312019Thomas R Gilbert Ashis SahaMary Jane Shultz Mary A MahaneyMichael Singer Jerry P JasinskiLisa Marcaurelle Raj (SB) Rajur Leland L Johnson Jr Matthew M JacobsenTerm Ends 12312020Michael P Filosa Robert LichterCarol Mulrooney Morton Z HoffmanPatricia A Mabrouk Sonja Strah-PleynetAnna W Sromek Andrew ScholteSofia A Santos Patrick M Gordon

All Chairs of standingCommittees the editor of THE NUCLEUS and the Trustees of SectionFunds are members of theBoard of Directors AnyCoun cilor of the American Chemical Societyresiding within the section area is an ex officiomember of the Board of Directors

ContentsGustavus John Esselen II_________________________________2The Award and the Man

2018 NESACS Candidates for Election _____________________4

Monthly Meeting _______________________________________5Esselen Award Meeting at the Charles Hotel and Pfizer LectureHall Jennifer A Doudna UCal Berkeley to Receive 2018 Esselen Award Date Friday April 27 2018

In Memory of Ted Taylor _________________________________6By Michael P Filosa

Historical Notes________________________________________6William Klemperer Edward C Taylor Jr and John J Giuffrida

Announcements_____________________________________279Northeast Student Chemistry Research Conference NESACSat Fenway Park Senior Chemists Luncheon

Gustavus John Esselen Award _____________________________8Prior Recipients

Business Directory ____________________________________11

Calendar ____________________________________________12

Cover Professor Jennifer A Doudna University of California at Berkeley2018 recipient of the Gustavus J Esselen Award for Chemistry in the Public In-terest (Photo courtesy of Professor Doudna)

Editorial Deadlines Summer-September Issue July 22 2018October 2018 Issue August 22 2018

2018NESACSCandidatesfor ElectionChair-Elect

Dr Sofia Santos Dr Anna Sromek

CouncilorAlternate CouncilorDr Ajay Purohit Dr Ashis Saha Ms June LumDr Malika Jeffries-ElDr Katherine Lee Dr Catherine CostelloDr Ruth TannerDr Kenneth MattesDr Morton Z HoffmanDr Andrew Scholte Dr Patrick CappillinoDr Raj RajurDr Joshua SacherDr Mariam IsmailDr Hicham FenniriDr Daljit Matharu

Treasurer (2 year term)Dr Ashis Saha

Trustee (3 year term 1 elected)Dr Peter MeltzerDr Bob Lichter

Director-at-Large (3 year term 2elected)

Dr June Lum Dr John NeumeyerDr John Burke

Nominating Committee (1 yearterm 2 elected)

Dr Michael P FilosaDr Sonya Strah-Pleynet

Norris Committee (4 year term 2elected)

Dr K M AbrahamDr Vasiliki LykourinouDr Mark Tebbe

Petition Candidates ldquoAny group com-prising two per cent or more of theNortheastern Section may nominatecandidateshelliphelliprdquo See NESACS websitefor details u

4 The Nucleus April 2018

NESACS Sponsors 2017Platinum $5000+Boston Foundation Esselen AwardSK Life ScienceAmgen IncJohnson MattheyVertex PharmaceuticalsDavos PharmaBiogenPCI SynthesisNavin Fluorine International Ltd

Gold $3000 up to $5000Merck Research CorpSignal PharmaceuticalsJ-Star ResearchIPG Women ChemistsAbbvie

Silver $1500 up to $3000Mettler ToledoSanofi US ServicesWarp Drive BioPfizerLAVIANAStrem Chemicals

Bronze $500 up to $1500Chemical Computing GroupXtuit PharmaceuticalsCydan Development IncAchillion PharmaceuticalsAlkermesFLAMMASafety Partners IncPiramal Pharma SolutionsrsquoSelvita IncOrganixCreaGen Life ScienceEntasis TherapeuticsMorphic TherapeuticInterchim IncXtal BiostructuresQuartet MedicineAnton Parr USABiotageBioduroNovalix PharmaThermo FisherCresset GroupCustom NMR Services

R

This graduate level course concentrates on the fundamentals that are useful in drug discovery spanning initial target assay evaluation through clinical development Case histories of recent successful drug development programs will also be presented The five-day program covers

Principles of Med Chem DMPK Cheminformatics Toxicophores

Lead ID amp Optimization GPCRs Epigenetics Kinase Inhibitors Fragment-based Drug Design Ion Channels Structure-based Drug Design Enzyme Inhibitors Drug-like Properties Bioisosteres Protein-Protein Interactions Preclinical Toxicology

Molecular Modeling Clinical Development Antibody-Drug Conjugates

Bill Greenlee Vince Gullo amp Ron Doll ndash Co-organizers

ResMed Residential School on Medicinal Chemistry and Biology in Drug Discovery

June 10-15 2018Drew University Madison NJ

Attendees will be staying at the Madison Hotel

wwwdreweduresmed e-mail resmeddrewedu

phone 973408-3787 fax 973408-3504

NewNESACSBylaws AllowElectronicElections2018 will be the first electronicNESACS Election ndash Watchyour emailLike the National American ChemicalSociety Elections and the Division ofOrganic Elections NESACS will nowhold electronic elections This changeneeded to be described in the NESACSBylaws before it could be implementedThe approval of new bylaws at the Jan-uary Meeting now allows NESACS tomove to a more member-friendly and ef-ficient way of holding elections It isalso more cost-effective

Historically NESACS has pub-lished candidate statements in the MayNucleus which was assembled in a largeenvelope with a paper ballot and a returnenvelope This assemblage was thenmailed to each of our 6000 members

continued on page 10

2018NESACSCandidatesfor ElectionChair-Elect

Dr Sofia Santos Dr Anna Sromek

CouncilorAlternate CouncilorDr Ajay Purohit Dr Ashis Saha Ms June LumDr Malika Jeffries-ElDr Katherine Lee Dr Catherine CostelloDr Ruth TannerDr Kenneth MattesDr Morton Z HoffmanDr Andrew Scholte Dr Patrick CappillinoDr Raj RajurDr Joshua SacherDr Mariam IsmailDr Hicham FenniriDr Daljit Matharu

Treasurer (2 year term)Dr Ashis Saha

Trustee (3 year term 1 elected)Dr Peter MeltzerDr Bob Lichter

Director-at-Large (3 year term 2elected)

Dr June Lum Dr John NeumeyerDr John Burke

Nominating Committee (1 yearterm 2 elected)

Dr Michael P FilosaDr Sonya Strah-Pleynet

Norris Committee (4 year term 2elected)

Dr K M AbrahamDr Vasiliki LykourinouDr Mark Tebbe

Petition Candidates ldquoAny group com-prising two per cent or more of theNortheastern Section may nominatecandidateshelliphelliprdquo See NESACS websitefor details u

4 The Nucleus April 2018

NESACS Sponsors 2017Platinum $5000+Boston Foundation Esselen AwardSK Life ScienceAmgen IncJohnson MattheyVertex PharmaceuticalsDavos PharmaBiogenPCI SynthesisNavin Fluorine International Ltd

Gold $3000 up to $5000Merck Research CorpSignal PharmaceuticalsJ-Star ResearchIPG Women ChemistsAbbvie

Silver $1500 up to $3000Mettler ToledoSanofi US ServicesWarp Drive BioPfizerLAVIANAStrem Chemicals

Bronze $500 up to $1500Chemical Computing GroupXtuit PharmaceuticalsCydan Development IncAchillion PharmaceuticalsAlkermesFLAMMASafety Partners IncPiramal Pharma SolutionsrsquoSelvita IncOrganixCreaGen Life ScienceEntasis TherapeuticsMorphic TherapeuticInterchim IncXtal BiostructuresQuartet MedicineAnton Parr USABiotageBioduroNovalix PharmaThermo FisherCresset GroupCustom NMR Services

R

This graduate level course concentrates on the fundamentals that are useful in drug discovery spanning initial target assay evaluation through clinical development Case histories of recent successful drug development programs will also be presented The five-day program covers

Principles of Med Chem DMPK Cheminformatics Toxicophores

Lead ID amp Optimization GPCRs Epigenetics Kinase Inhibitors Fragment-based Drug Design Ion Channels Structure-based Drug Design Enzyme Inhibitors Drug-like Properties Bioisosteres Protein-Protein Interactions Preclinical Toxicology

Molecular Modeling Clinical Development Antibody-Drug Conjugates

Bill Greenlee Vince Gullo amp Ron Doll ndash Co-organizers

ResMed Residential School on Medicinal Chemistry and Biology in Drug Discovery

June 10-15 2018Drew University Madison NJ

Attendees will be staying at the Madison Hotel

wwwdreweduresmed e-mail resmeddrewedu

phone 973408-3787 fax 973408-3504

NewNESACSBylaws AllowElectronicElections2018 will be the first electronicNESACS Election ndash Watchyour emailLike the National American ChemicalSociety Elections and the Division ofOrganic Elections NESACS will nowhold electronic elections This changeneeded to be described in the NESACSBylaws before it could be implementedThe approval of new bylaws at the Jan-uary Meeting now allows NESACS tomove to a more member-friendly and ef-ficient way of holding elections It isalso more cost-effective

Historically NESACS has pub-lished candidate statements in the MayNucleus which was assembled in a largeenvelope with a paper ballot and a returnenvelope This assemblage was thenmailed to each of our 6000 members

continued on page 10

The Nucleus April 2018 5

Monthly MeetingThe 978th Meeting of the Northeastern Section of the AmericanChemical Society-Esselen Award MeetingFriday April 27 2018The Charles Hotel Cambridge MARegattabar One Bennett St 3rd Floor500 pm Social Hour600 pm Dinner

Harvard University Cambridge MAMallinckrodt Building 12 Oxford St800 pm Award Meeting

Pfizer Lecture Hall (MB23) ground floorAndrew Scholte NESACS Chair-Elect presiding

Welcome and Award History ndash Karen Allen Chair Esselen Award Committee

Presentation of the Award - Gustavus J Esselen IV Introduction of the Award Recipient ndash Michael A Marletta

2007 Esselen Award Winner University of California Berkeley Re-writing the Code of Life The Impacts and Ethics of Genome

Editing ndash Jennifer A Doudna Howard Hughes Medical Institute Investigator Li Ka-shing Chancellorrsquos Chair in Biomedical andHealth Sciences Professor Departments of Molecular amp Cell Biol-ogy and Chemistry at University of California Berkeley ExecutiveDirector Innovative Genomics Institute

Dinner reservations should be made no later than noon Friday April 20 Reser-vations are to be made using EventBrite services https2018-esselen-nesacseventbritecom Select the Gustavus John Esselen Award for Chemistry in thePublic Interest and the appropriate ticket package Members $3000 Non-mem-bers $35 Retirees $20 Students $10 Reservations for new members and foradditional information contact the secretary Anna Singer at (781)272-1966 ore-mail at secretarynesacsorg Reservations not cancelled at least 24 hours inadvance must be paid

THE PUBLIC IS INVITED ndash RESERVATIONS ARE REQUIREDLimited Free Parking available in the Garage at 52 Oxford St Identify yourselfas attending the EsselenHarvard Chemistry event and the guard will direct youParking is also available at the Charles Hotel For arrival after 500PM self-parking is $10 valet is $15 u

Abstract CRISPR Systems Chemistry andApplications of Gene Editing Gene editing with CRISPR technologyis transforming agriculture and biomed-icine Understanding the underlyingchemical mechanisms of RNA-guidedDNA and RNA targeting provides afoundation for both conceptual advancesand technology development I will dis-cuss how bacterial CRISPR adaptiveimmune systems inspire creation ofpowerful genome engineering tools en-abling advances in understanding thefundamental chemistry and biology ofliving systems and paving the way forapplications in agriculture and biomed-icine I will also discuss the ethical chal-lenges of some of these applications u

BiographyJennifer A Doudna PhDAs an internationally renowned profes-sor of Chemistry and Molecular and CellBiology at UC Berkeley Doudna andher colleagues rocked the research worldin 2012 by describing a simple way ofediting the DNA of any organism usingan RNA-guided protein found in bacte-ria This technology called CRISPR-Cas9 has opened the floodgates ofpossibility for human and non-humanapplications of gene editing includingassisting researchers in the fight againstHIV sickle cell disease and musculardystrophy Doudna is an Investigatorwith the Howard Hughes Medical Insti-tute and a member of the National Acad-emy of Sciences the National Academyof Medicine the National Academy ofInventors and the American Academy ofArts and Sciences She is also a ForeignMember of the Royal Society and hasreceived many other honors includingthe Breakthrough Prize in Life Sciencesthe Heineken Prize the BBVA Founda-tion Frontiers of Knowledge Award andthe Japan Prize She is the co-authorwith Sam Sternberg of ldquoA Crack in Cre-ationrdquo a personal account of her researchand the societal and ethical implicationsof gene editing u

New MembersInvitation to attend a meetingYou are cordially invited to attend one of our upcoming Section meetings as a guestof the Section at the social hour and dinner preceding the meeting

Please call Anna Singer at 781-272-1966 between 9am-6pm or email secre-tary(at)nesacsorg by noon of the first Thursday of the month letting her know thatyou are a new member u

6 The Nucleus April 2018

In Memoryof Ted TaylorBy Michael P FilosaThe passing of Ted Taylor is not just thepassing of an icon of Organic Chem-istry but the loss of a long-time friendand mentor

In addition to Tedrsquos well-knownconsulting activities with Eli Lilly thatled to the development of the anti-can-cer drug Alimta Ted was a long-timeconsultant to the Polaroid CorporationHe followed Saul Cohen and NobelLaureates Robert B Woodward and SirDerek H R Barton in that role

Ted had a natural connection to Po-laroid His expertise and that of his stu-dents in heterocyclic chemistry was veryvaluable to Polaroidrsquos organic chemistryefforts

One of his PhD students AlanBorror was the head of Organic Chem-istry at the time of my arrival at Polaroidin late 1979 In 1988 John Warner joinedPolaroid after receiving his PhD withTed

Director of Chemical ResearchLloyd D Taylor had a great affinity forTed his work and his students Lloydencouraged John to study hydrogen-bonded complexes and use them tosolve some of Polaroidrsquos chemical prob-lems These complexes were the genesisof Johnrsquos interest in the principles ofGreen Chemistry

Around 1991 Ted stopped his con-sulting relationship with Kodak and be-came the Organic Chemistry consultantfor Polaroid Chemical Research After ayear or two I became the host for hisquarterly visits

Ted loved to stop in Cambridge onhis way to Vermont and would stay at theMarriott in Kendall Square We wouldmeet for dinner at the Legal Sea Foodsdownstairs This was one of his favoriteplaces I think I developed my taste forCajun-style blue fish at those dinners

The next morning we often enjoyedthe breakfast buffet at the Marriott Wethen spent the day discussing Polaroidchemistry

Steve Telfer would talk about hislatest efforts to reinvent imaging with

acid-amplifiers or the thermal imagingefforts that led to the invention of ZINKpaper and the Opal photo kiosk technol-ogy

We would talk about the dye chem-istry and developer chemistry we wereworking on to support our legacy silverhalide imaging products

This work included the dimethyl-terephthalamide-hydroquinone com-plexes developed by John Warnerwhich solved stability and solubility is-sues with several of our preferred hydro-quinone developers

As Polaroidrsquos chemical research ef-fort diminished through the 1990rsquos it be-came harder to find a full day of topicsfour times a year Given Tedrsquos wide-ranging interests and enthusiasm it wasnever a problem

Ted as much as he could wouldtell us about his work leading to Alimtathe toxicity issue encountered in its test-ing and its solution (addition of folicacid to the treatment) or his experiencesas an expert witness at various trialsThese included trials in which his owninventions were attacked

One interesting story I recall is theindustrial espionage that happened dur-ing his Alimta efforts New targets weredrawn up and were in a briefcase be-longing to one of his students The brief-case was stolen and the structures insideit started appearing in the patents of aforeign competitor

Another story was the fishpond heattempted to have constructed on his500-acre property in Woodstock Ver-mont It turned out to be an expensivebut entertaining fiasco except for the

fish stocked in the failed pondTed was also a passionate golfer

He told us the story of how he was apassionate tennis player until he reached60 At that point he decided he needed anew sport and that it would be one hecould share with his wife Ted decidedthat sport was golf and he became a low-handicap golfer

A number of us would meet Ted onhis visits to play golf I remember onetime meeting him at Stow Acres andplaying the old South Course We hadextra time so we went to the drivingrange and spend the end of our sessionusing wedges to aim at the flagsticks

During our round I had one of themore successful experiences in mymediocre (and limited) golf career Onthe 18th hole I hit a nice (straight) drivefrom the elevated tee that carried thepond in the middle of the fairway

HistoricalNotesWilliam KlempererOctober 6 1927ndashNovember 5 2017William Klemperer Erving Professor ofChemistry Emeritus at Harvard Univer-sity died November 5 at the age of 90Bill was a physical chemists with a pri-mary expertise in molecular spec-troscopy

He was born in New York CityUpon graduation from New RochelleHigh School in 1944 he joined the USNavy Air Corps In 1946 he enteredHarvard and majored in Chemistry AtHarvard he met and married his wifeElizabeth Cole a Radcliffe student

Upon receiving his A B in 1950Bill and Elizabeth headed to the Univer-sity of California Berkeley where he re-ceived his PhD in Physical Chemistryunder the direction of George PimentelAfter a semester as an instructor atBerkeley he returned to Harvard as aninstructor in July 1954 He moved rap-idly up the academic ladder and becamea full professor in 1965 Over his careerhe mentored 67 PhD students 34 post-doctoral fellows and many undergradu-

continued on page 7

Two contemporaries at the 2010 Boston ACSMeeting (L) Myke Simon Harvard AB 1946PhD 1949 and (R) Ted Taylor Cornell AB1946 and PhD 1949 (Photo by Michael Filosa)

continued on page 10

NESACS at Fenway ParkMonday May 14th 2018 - 710 pm

Oakland Athletics vs Red SoxThank you to Doris Lewis for securing our seats in the Grand Stand again this year

Join us for an evening at Fenway Park for NESACS SummerThingTickets are $35 each

To purchase tickets please use our Eventbrite sitehttpswwweventbritecomenesacs-summerthing-monday-may-14th-tickets-

43023952801

ates He became an emeritus professorin 2002

From 1979-1981 he served as anAssistant Director for the Mathematicaland Physical Sciences He also served asan advisor to NASA and as a consultantto assess experiments related to stratos-pheric ozone depletion He receivedmajor awards from the American Chem-ical Society the American Physical So-ciety and the Royal Chemistry Society

From the American Chemical Soci-ety he received the Irving LangmuirAward (1980) the Peter Debye Awardin Physical Chemistry (1994) and the EBright Wilson Award in Spectroscopy(2001) He received the Earle K PlylerPrize for Molecular Spectroscopy fromthe American Physical Society (1983)and the Faraday Medal and Lectureshipfrom the Royal Society of Chemistry(1995)

Bill was elected a member of the

American Academy of Arts and Sci-ences (1963) and the National Academyof Sciences (1969)

Bill is survived by his wife and hischildren Joyce Paul and Wendy

Edward C Taylor JrAugust 3 1923ndashNovember 22 2017Ted Taylor A Barton Hepburn Profes-sor of Organic Chemistry Emerituspassed away November 22 2017 at theage of 94 while living at the home of hisdaughter Susan Spielman in St PaulMinnesota He was preceded in death in2014 by his wife of 68 years Virginia(Crouse) Taylor

Ted was born in Springfield Mas-sacusetts on August 3 1923 He quicklyexhausted the chemical offerings ofHamilton College and moved to CornellUniversity to complete his A B andPhD degrees After receiving his PhDin 1949 he was a Merck PostdoctoralFellow with Leopold Ruzicka in ZurichSwitzerland

He joined the faculty of the Univer-

sity of Illinois in 1951 before moving toPrinceton in 1954 He was appointed theA Barton Hepburn Professor of OrganicChemistry in 1966 a position he helduntil 1997 when he was appointedEmeritus Professor and senior researchchemist

Taylor wrote more than 460 papersand holds 52 US Patents He is the au-thor or co-editor of 89 books on hetero-cylic chemistry and organic synthesis

Ted is survived by his son NedTaylor (Connie) and his daughter SusanSpielman (Rick) He is also survived by9 grandchildren and 20 great-grandchil-dren

John J Giuffrida1931ndash2014John J Giuffrida82 of Laconia NHpassed away on Sunday afternoon June8 2014 as the result of a tragic accidentHis family was with him when hepassed

John was born in Lawrence Mas-

The Nucleus April 2018 7

Historical NotesContinued from page 6

continued on page 10

NESACS at Fenway ParkMonday May 14th 2018 - 710 pm

Oakland Athletics vs Red SoxThank you to Doris Lewis for securing our seats in the Grand Stand again this year

Join us for an evening at Fenway Park for NESACS SummerThingTickets are $35 each

To purchase tickets please use our Eventbrite sitehttpswwweventbritecomenesacs-summerthing-monday-may-14th-tickets-

43023952801

ates He became an emeritus professorin 2002

From 1979-1981 he served as anAssistant Director for the Mathematicaland Physical Sciences He also served asan advisor to NASA and as a consultantto assess experiments related to stratos-pheric ozone depletion He receivedmajor awards from the American Chem-ical Society the American Physical So-ciety and the Royal Chemistry Society

From the American Chemical Soci-ety he received the Irving LangmuirAward (1980) the Peter Debye Awardin Physical Chemistry (1994) and the EBright Wilson Award in Spectroscopy(2001) He received the Earle K PlylerPrize for Molecular Spectroscopy fromthe American Physical Society (1983)and the Faraday Medal and Lectureshipfrom the Royal Society of Chemistry(1995)

Bill was elected a member of the

American Academy of Arts and Sci-ences (1963) and the National Academyof Sciences (1969)

Bill is survived by his wife and hischildren Joyce Paul and Wendy

Edward C Taylor JrAugust 3 1923ndashNovember 22 2017Ted Taylor A Barton Hepburn Profes-sor of Organic Chemistry Emerituspassed away November 22 2017 at theage of 94 while living at the home of hisdaughter Susan Spielman in St PaulMinnesota He was preceded in death in2014 by his wife of 68 years Virginia(Crouse) Taylor

Ted was born in Springfield Mas-sacusetts on August 3 1923 He quicklyexhausted the chemical offerings ofHamilton College and moved to CornellUniversity to complete his A B andPhD degrees After receiving his PhDin 1949 he was a Merck PostdoctoralFellow with Leopold Ruzicka in ZurichSwitzerland

He joined the faculty of the Univer-

sity of Illinois in 1951 before moving toPrinceton in 1954 He was appointed theA Barton Hepburn Professor of OrganicChemistry in 1966 a position he helduntil 1997 when he was appointedEmeritus Professor and senior researchchemist

Taylor wrote more than 460 papersand holds 52 US Patents He is the au-thor or co-editor of 89 books on hetero-cylic chemistry and organic synthesis

Ted is survived by his son NedTaylor (Connie) and his daughter SusanSpielman (Rick) He is also survived by9 grandchildren and 20 great-grandchil-dren

John J Giuffrida1931ndash2014John J Giuffrida82 of Laconia NHpassed away on Sunday afternoon June8 2014 as the result of a tragic accidentHis family was with him when hepassed

John was born in Lawrence Mas-

The Nucleus April 2018 7

Historical NotesContinued from page 6

continued on page 10

8 The Nucleus April 2018

1987 - F Sherwood Rowland Univer-sity of California at Irvine and MarioJ Molina now at the MassachusettsInstitute of Technology Discovery ofthe Influence of Chlorofluorocarbonson the Ozone Layer

1988 - Alfred P Wolf and Joanna SFowler Brookhaven National Labora-tories Chemical Procedures to MakePositron Emission Tomography a Prac-tical Method in Medical Diagnosis

1989 - Carl Djerassi Stanford Univer-sity Synthesis and Promotion of theFirst and Most Common Birth ControlHormone

1990 - Thomas J Dougherty RoswellPark Cancer Institute The Develop-ment of Photodynamic Therapy for theTreatment of Malignant Disease

1991 - Jerrold Meinwald and ThomasEisner Cornell University ChemicalResponses in the Insect and PlantWorld

1992 - Bruce N Ames University ofCalifornia at Berkeley Methods forDetection of Carcinogens and Causesof Aging and Cancer

1993 - James G Anderson HarvardUniversity Experimental Methods forMeasuring Global Ozone Loss

1994 - Kary B Mullis The Discovery ofPolymerase Chain Reactions (PCR)for the Replication of DNA Molecules

1995 - Howard J Schaeffer BurroughsWellcome Company Nucleosides withAntiviral Activity-The Discovery ofAcyclovir (Zoviraxreg)

1996 - Roy G Gordon Harvard Univer-sity Low Emissivity Glass EnergyConserving Windows

1997-Rangaswamy Srinivasan UVTechAssociates The Widely Used LaserMethodology of Tiny Focused AblativePhotodecomposition

1998 - Kyriacos C Nicolaou ScrippsResearch Institute Chemical Synthesisand Chemical Biology of Natural Sub-stances

1999 - Robert S Langer MassachusettsInstitute of Technology The Develop-ment of Unique Polymers for MedicalApplications

2000 - William A Pryor Louisiana StateUniversity Vitamin E and the Preven-tion of Heart Disease

2001 - Joseph M DeSimone Universityof North Carolina and North CarolinaState University Green Chemistry forSustainable Economic Development

2002 - Ronald Breslow Columbia Uni-versity Chemistry Lessons from Biol-ogy and vice versa

2003 - Bruce D Roth Pfizer Global Re-search amp Development The Discov-ery and Development of Lipitorreg(Atorvastatin Calcium)

2004 - James W Jorgenson Universityof North Carolina The Magic of Cap-illaries in Chemical Separations andAnalysis

2005 - Jean M J Freacutechet University ofCalifornia at Berkeley FunctionalMacromolecules From Design andSynthesis to Applications

2006 - Richard D DiMarchi Universityof Indiana Chemical Biotechnologyas a Means to Optimal Protein Ther-apeutics

2007 - Michael A Marletta Universityof California at Berkeley Nitric Oxidein Biology From Discovery to Thera-peutics

2008 - John A KatzenellenbogenSwanlund Professor of ChemistryUniversity of Illinois at Champaign-Urbana Estrogens and Estrogen re-ceptors as a Nexus of Chemistry andBiology in Health and Disease

2009 - Chad A Mirkin Director of theInternational Institute for Nanotech-nology George B Rathmann Professorof Chemistry Professor of BiomedicalEngineering Professor of Biologicaland Chemical Engineering Professorof Medicine and Professor of Materi-als Science and Engineering North-western University Nanostructures inChemistry Biology and Medicine

2010 - Stephen L Buchwald CamilleDreyfus Professor of Chemistry De-partment of Chemistry Massachu-setts Institute of Technology Pd- andCu-Catalyzed Processes for the Syn-thesis of Pharmaceuticals

2011 - Arthur J Nozick Senior Re-search Fellow National RenewableEnergy Laboratory and Professor Ad-junct Department of Chemistry andBiochemistry University of ColoradoBoulder Prospects and Novel Ap-proaches for the Low Cost Power Con-version of Solar Photons to Electricityand Solar Fuels

2012 - Bruce Ganem Franz and Elisa-beth Roessler Professor of Chemistryand Stephen H Weiss Presidential Fel-low at Cornell Lost (Sometimes) InTranslation Advancing Chemical Dis-coveries Beyond the Laboratory

2013 - Michael H Gelb Harry andCatherine Jaynne Bond Endowed Pro-fessor of Chemistry and Biochemistryat the University of Washington inSeattle and Frantisek Turecek Chem-istry Department at University ofWashington The New GenerationChemistry for Newborn Screening

2014 - David R Walt Robinson Profes-sor of Chemistry and Howard HughesMedical Institute Professor Tufts University Microwell Arrays FromGenetic Analysis to Ultra-High Sensi-tivity Diagnostics

2015 - Eric Jacobsen Sheldon EmoryProfessor of Organic Chemistry Har-vard University Catalysis A Frontierat the Center of Chemistry

2016 ndash Timothy M Swager John DMacArthur Professor of ChemistryMIT and Director of the DeshpandeCenter for Technological InnovationChemicalBiological Sensing Scienceand Real World Applications

2017 ndash Neil M Donahue Thomas LordProfessor of Chemistry Chemical En-gineering and Engineering and PublicPolicy Carnegie-Mellon UniversityAtmospheric Ozonolysis From Colli-sional Energy Transfer to ParticlePhysics and Everything in Between

2018 ndash Jennifer A Doudna HowardHughes Institute Investigator Ka-shingChancellorrsquos Chair in Biomedical andHealth Sciences Professor of Bio-chemistry Biophysics and Structural

Gustavus John Esselen Award Prior Recipients of the Gustavus John Esselen Award

continued on page 9

The Nucleus April 2018 9

NESACS SENIOR CHEMISTS LUNCHEONMonday April 30 2018 Panera Bread 2pm-4pm

1684 Massachusetts Avenue Lexington MA

PHOTO COURTESY OF DORIS LEWIS

Please join us for relaxed fellowship and a chance to catchup with each other and with ACS news

Family and friends welcomeTo register contact Anna Singer secretarynesacsorg

Lunch is reimbursable with receipt (up to $10)

Biology University of Califor-niaBerkeley Re-writing the Code of LifeThe Impacts and Ethics of GenomeEditing u

Esselen AwardContinued from page 8

and served as councilor and director ofthe national organization during whichtime he was a member of the ACSCouncil Policy Committee His chair-manship of the national ACS meetingsheld in Boston in 1928 and 1939 was anoutstanding service He was on the ad-visory boards of IEC and CampE News1946-48 In 1948 he received the JamesFlack Norris Honor Scroll as ldquothe per-son who has done most to advance theinterests of the Northeastern SectionrdquoIn 1950 he was made an honorary mem-ber of the American Institute ofChemists for his services to the profes-sion of chemistry and chemical engi-neering From 1919 to 1951 he waschairman of the American Section of theSociety of Chemical Industry Prior toWorld War II he was a reserve officer inthe US Armyrsquos Chemical WarfareService During the war he was a com-mittee chairman with the Office of Sci-entific Research and Development

Esselenrsquos distinguished contribu-tions to chemistry and chemical engi-neering were in accordance with thehighest ethics of these professions hisrecognition of the duties of a profes-sional led to his exertion of a wise andbeneficent influence on all the profes-sional societies to which he gave so gen-erously of his time and led to hisparticipation in numerous civic activitiesin the Boston area Esselen was a verysensitive person devoted throughout hislife to the fine arts and music His mottocontained on a tapestry in his office wasa quotation of Richard Wilstaumltter ldquoIt isour destiny not to create but to unveilrdquoAdapted from Edward R Atkinson inWD Miles (Ed) ldquoAmerican Chemistsand Chemical Engineersrdquo AmericanChemical Society Washington DC1976 p 147 u

Gustavus Esselen IIContinued from page 2

The Nucleus April 2018 9

NESACS SENIOR CHEMISTS LUNCHEONMonday April 30 2018 Panera Bread 2pm-4pm

1684 Massachusetts Avenue Lexington MA

PHOTO COURTESY OF DORIS LEWIS

Please join us for relaxed fellowship and a chance to catchup with each other and with ACS news

Family and friends welcomeTo register contact Anna Singer secretarynesacsorg

Lunch is reimbursable with receipt (up to $10)

Biology University of Califor-niaBerkeley Re-writing the Code of LifeThe Impacts and Ethics of GenomeEditing u

Esselen AwardContinued from page 8

and served as councilor and director ofthe national organization during whichtime he was a member of the ACSCouncil Policy Committee His chair-manship of the national ACS meetingsheld in Boston in 1928 and 1939 was anoutstanding service He was on the ad-visory boards of IEC and CampE News1946-48 In 1948 he received the JamesFlack Norris Honor Scroll as ldquothe per-son who has done most to advance theinterests of the Northeastern SectionrdquoIn 1950 he was made an honorary mem-ber of the American Institute ofChemists for his services to the profes-sion of chemistry and chemical engi-neering From 1919 to 1951 he waschairman of the American Section of theSociety of Chemical Industry Prior toWorld War II he was a reserve officer inthe US Armyrsquos Chemical WarfareService During the war he was a com-mittee chairman with the Office of Sci-entific Research and Development

Esselenrsquos distinguished contribu-tions to chemistry and chemical engi-neering were in accordance with thehighest ethics of these professions hisrecognition of the duties of a profes-sional led to his exertion of a wise andbeneficent influence on all the profes-sional societies to which he gave so gen-erously of his time and led to hisparticipation in numerous civic activitiesin the Boston area Esselen was a verysensitive person devoted throughout hislife to the fine arts and music His mottocontained on a tapestry in his office wasa quotation of Richard Wilstaumltter ldquoIt isour destiny not to create but to unveilrdquoAdapted from Edward R Atkinson inWD Miles (Ed) ldquoAmerican Chemistsand Chemical Engineersrdquo AmericanChemical Society Washington DC1976 p 147 u

Gustavus Esselen IIContinued from page 2

10 The Nucleus April 2018

This process was inherently inefficientand expensive

Moreover very few of our mem-bers chose to respond and elections weredecided by less than 10 per cent of ourmembership In 2017 less than 300members voted By switching to elec-tronic elections we hope to get betterparticipation in elections We will alsosave many thousands of dollars and savea lot of wasted paper

For several years we haveprinted and mailed less than 300 copiesof the Nucleus We intend to eventuallymove to totally electronic delivery of theNucleus It was an anachronism to con-tinue to have to mail 6000 copies of theNucleus with candidate statements andballots to our membership simply be-cause of the wording of our bylaws

The committee led by 2017 ChairLeland Johnson Jr that worked hard onrevising the NESACS Bylaws deservesa great deal of credit for working withNational ACS to expeditiously imple-ment this changeMPF u

Electronic ElectionsContinued from page 4

sachusetts on October 191931 and wasthe son of Giuseppe and Orazio (Faro)Giuffrida

In 1955 he graduated with honorsfrom Boston College where he receivedhis Bachelorrsquos Degree in Chemistry In1957 he married Jacqueline Masuhr ofHaverhill Massachusetts and they wenton to have 3 daughters and a son

John began his career in the chem-ical industry working for Dow ChemicalCompany in Midland MI He later re-turned to Massachusetts working forCabot Corporation He retired in 1993as a Regional Sales Manager for CabotCorporation in Annandale NJ

John spent his retirement years inthe area he loved most the Lakes Re-gion of New Hampshire He had severalhobbies including golf and fishingThroughout his life he was also passion-ate about cooking and everyone alwaysenjoyed his Italian family recipes Hewas also known for his quick wit andgood humor

John is survived by an older sisterhis wife four children and seven grand-children u

Historical NotesContinued from page 7

My fairway wood left me about 80yards short of the green on the par 5 Ipulled out my sand wedge and the shotI hit was dead on I was jumping up anddown thinking it was going in I endedup with a 1-foot putt for birdie I wouldsay it was the best golf hole I everplayed and it was with Ted and a directresult of our little game of target practiceat the range

Ted was a remarkable organicchemist I remember bumping into himin San Francisco at the March 2010ACS Meeting Ted was there to receivethe Alfred Burger Award in MedicinalChemistry from the ACS for his work onAlimta The award was truly an amazingachievement the foundation of whichwas his earliest work on the pigments inbutterfly wings By the end of 2010 Al-imta stood as the most successful newcancer drug based on sales in the his-tory of the pharmaceutical industry

Ted was an amazing scientist withgreat charisma He was an extraordinaryrole model and friend I have greatmemories of my times with Ted and willmiss him greatly u

Ted TaylorContinued from page 6

Whatrsquos YoursDMPK Scientist

LCMS Product Specialist Mass Spec Operator

Staff Investigator Process Chemist

QA Manager Synthetic Chemist Lab Instructor

Many local employers post positions on the NESACS job board

Find yours atwwwnesacsorgjobs

Have you checked the NESACS website

Updated frequentlyConsult for late-breaking news

position postingsLatest meeting and event information

WWWNESACSorg

Q Exactly how many awards andscholarships does NESACS sponsor

A) One b) Two c) Many

wwwnesacsorgawards

The Nucleus April 2018 11

SERVICESSERVICES

B U S I N E S S D I R E C T O R Y

SERVICES

Index of AdvertisersDrew University 4Eastern Scientific Co 9Micron Inc 11Organix Inc 11PCI Synthesis11Robertson Microlit Labs11

JoinNESACS

on facebookwwwfacebookcomnesacs

Whatrsquos YoursMany local employers post positions

on the NESACS job board

Find yours atwwwnesacsorgjobs

Check the NESACS home pagefor late Calendar additionshttpwwwNESACSorgNote also the Chemistry Department webpages for travel directions and updatesThese includehttpwwwbceduschoolscaschemistrys

eminarshtmlhttpwwwbueduchemistryseminarshttpwwwbrandeisedudepartmentschem

istryeventsindexhtmlhttpchemistryharvardeducalendarupco

minghttpwwwnortheasterneducoschemistry

events-2httpchemistrymitedueventsallhttpchemtuftseduseminarshtmlhttpengineeringtuftseduchbenewsEven

tsseminarSeriesindexasphttpwwwchemumbeduhttpwwwumassdeducaschemistryhttpwwwumleduScienceschemistrySe

minars-and-Colloquiaaspxhttpwwwunheduchemistryeventshttpswwwwpieduacademicsdepartmen

tschemistry-biochemistry

April 2Prof Karen Wooley (Texas AampM)Boston University Metcalf Rm 113400 pm

April 3Prof Taekjip Ha (Johns Hopkins)MIT Room 6-120 430 pmProf David Nicewicz (North Carolina-ChapelHill)Boston College Merkert 130 400 pm

Prof Gonghu Li (Univ of New Hampshire)ldquoSurface Molecular Catalysis for Solar Fuel Re-searchrdquoUniv of New Hampshire Parsons N1041110 am

April 4Prof Jeffery Byers (Boston College)Tufts Pearson Rm P106 1200 pmProf T Patrick Holland (Yale)ldquoNitrogen Fixation using Low-Coordinate IronComplexesrdquoMIT Room 4-370 415 pmProf Evan Miller (UCal-Berkeley)ldquoElectrophysiology Unplugged New ChemicalTools to Watch Cell PhysiologyrdquoBoston College Merkert 130 400 pm

April 5Prof Samie R Jaffrey (Weill Medical College-Cornell)Harvard Pfizer Lecture Hall 415 pmProf Paul Chirik (Princeton)Dartmouth Steele Rm 006 1030 am

April 6Prof Carolyn Bertozzi (Stanford)Harvard Pfizer Lecture Hall 415 pmProf Hicham Fenniri (Northeastern)UMass-Lowell Olney Hall Rm 218 330 pm

April 7Prof Colin Nuckolls (Columbia)MIT TBA

April 9Prof Mike Ward (NYU)Brandeis Gerstenzang 121 400 pmProf J Martin Bollinger (Penn State)MIT TBA 400 pmProf Corinna Schindler (Michigan)Boston University Metcalf Rm 113 400 pm

April 10Prof Steven Corcelli (Notre Dame)ldquoDynamics and Vibrational Spectroscopy of Mo-lecular Reporters in Ionic LiquidsrdquoTufts Pearson Rm P106 430 pmProf J Martin Bollinger (Pennsylvania StateUniversity)MIT TBA 400 pmProf David Thirumalai (University of Texas)MIT TBA 430 pmProf Wei Min (Columbia)ldquoSeeing Molecular Vibrations Chemical Imag-ing for BiomedicinerdquoMIT TBA 430 pmProf Eric Jacobsen (Harvard)ldquoAnion-Binding CatalysisrdquoBoston College Merkert 130 400 pmProf Caleb Martin (Baylor)ldquoExploiting the Diverse Chemistry of Boroles toAccess Unsaturated BoracyclesrdquoUniv of New Hampshire Parsons N1041110 am

April 11Prof Delia Milliron (Texas)Harvard TBA 415 pmProf Eric Jacobsen (Harvard)ldquoNew Stereoselective Catalytic Fluorination Re-actionsrdquoBoston College Merkert 130 400 pmProf Amir Mitchell (UMass Medical School)WPI Gateway Park Rm 1002 1200 pm

April 12Prof Eric Jacobsen (Harvard)ldquoInching toward Perfect CatalysisrdquoBoston College Merkert 130 400 pm

April 13Prof Rebekka Klausen (Johns Hopkins)Univ of New Hampshire Parsons W131 300 pm

April 17Prof Joseph Barchi Jr (NCI)Tufts Pearson Rm P106 430 pmProf Tomislav Rovis (Columbia)Boston College Merkert 130 400 pmProf Steven Suib (Univ of Connecticut)Univ of New Hampshire Parsons N1041110 am

April 18Prof Michael Rose (Texas)MIT Room 4-370 415 pm

April 19Prof Anna Mapp (Michigan)Harvard Pfizer Lecture Hall 415 pmProf Matthew Tucker (Nevada-Reno)Boston College Merkert 130 400 pm

April 20Prof Jianmin Gao (Boston College)ldquoCovalent Molecular Recognition via Imi-noboronate ChemistryrdquoUMass-Lowell Olney Hall Rm 218 330 pm

April 23Prof Chi Nguyen (MIT)MIT Rm 4-270 400 pmProf Alexei Stuchebrukhov (UCal-Davis)Boston University Metcalf Rm 113 400 pm

April 24Prof Poul Petersen (Cornell)Tufts Pearson Rm P106 430 pmProf Wei Min (Columbia)ldquoSeeing Molecular Vibrations Chemical Imag-ing for BiomedicinerdquoMIT TBA 430 pmProf Patricia Mabrouk (Northeastern)rdquoSo You Think Your Laboratory is Running WellWhen Did You Last Have a Conversation AboutAuthorship with Your StudentsrdquoUniv of New Hampshire Parsons N104 1110 am

April 25Prof Louise Berben (UCal-Davis)MIT Rm 4-370 415 pm

April 26Prof Elizabeth R Jarvo (UCal-Irvine)MIT Rm 6-120 400 pmProf Wilson Smith (Delft University)Boston College Merkert 130 400 pm

April 28Prof Stefan Hell (Max-Planck-Institute)Harvard Pfizer Lecture Hall 500 pm

April 30Prof Eric Jacobsen (Harvard)Boston University Metcalf Rm 113 400 pm

Notices for The NucleusCalendar of Seminars should besent toXavier Herault emailxheraultoutlookcom u

NO

NPRO

FIT ORG

U

S POSTA

GE PA

IDN

ORTH

EASTERN

SECTIO

NA

MERICA

N CH

EMICA

LSO

CIETY

Calendar

18 Tamarack Road

Medfield M

A 02052