JUVIC

Application of Microneedles in Cosmetic and Medicine

Hyungil Jung, Professor, Department of Biotechnology, Yonsei UniversityFounder and CEO, Juvic Inc.hijung@yonsei.ac.kr

JUVICJUVIC

Microneedle is referred to micro dimensioned needlesIt is a novel delivery method to deliver drugs across the skin in a minimally invasive manner

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Microneedle patch

Skin

Application Delivery

JUVICJUVIC

Microneedle can be utilized in various fields of beauty, medical, cell therapy and beauty clinics.

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Beauty

Beauty Clinic

Medical

Cell Therapy

Anti wrinkleWhiteningAlopecia treatment

Insulin patchPTHEPOMicrolancet

AcneAlopecia treatmentBotox

Influenza VaccineArthritis treatment

JUVIC

According to analysis of Frost & Sullivan, Microneedle was selected as top 10 technologies of Healthcare & Wellness in 2016

Frost & Sullivan, 2014

Microneedle market

Billion dollar"Drug delivery technology market has continued to grow rapidly due to impressive sales growth and trends."(BBC Research)

"Micro-needles are likely to replace existing syringes, which will increase demand for micro-needles in the future."(Frost & Suliivan)

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JUVIC

Currently, microneedle fabrication technologies are focused on cosmetics field.

You want to deliver1. Your valuable drugs2. Maintains its activity3. With high efficacy 

Main elements of dissolving microneedle delivery systems

Drug Loading

Fabrication

Application

JUVIC

Centrifugal Lithography

Activity of EGF

Activity of Ascorbic acid

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JUVIC

Drug‐Polymer solution MN MN 

Delivery

Centrifugal Lithography

Deliveryefficacy

Fabrication

PreparationStorage

Drug Activity

Process time

Drug

Solvent

JUVIC

All technologies are combinedInto innovative products 

through JUVIC

JUVIC provides Total solution for Healthcare with Microneedle

Innovative polymer system(Any drugs)

Can load all type of drugs by amphipathic polymer system

Formulation Technology

Centrifugal lithography(Various conditions)

Can control easily the conditions to conserve the activity of drug

Fabrication Technology

Micro injector(Perfect delivery)

Can deliver DMN in high efficacyby shooting DMN into skin 

Delivery Technology

JUVIC

Juvic is a technology based start-up.

Publications and patents Various patents on microneedle fabrication and

delivery methods (5 registered, 40 applied) Advanced Materials (2010, 2012), Scientific

Reports (2015) etc. about 30 publications

Achievements Yonsei University Industry-University Cooperation

Excellence Award (2009) Yonsei University Award of Excellent Achievement The 1st Yonsei University startup Award (2016) Awarded from Ministry of the Future Creation

Science Prize for Excellent Technology Commercialization (2015)

Technology transfer 7 transfers, 2 successful production

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RepresentativeHyungil Jung, Junbae Kim

Founded on 2015.10.

LocationYonsei University, Engineering Park

Main ownersHyungil JungYonsei University, etc.

JUVIC

We are carrying out various national R&D projects in both cosmetics and medical fields.

Project Title Department Our role Assignment amount Duration

New Industry Creation ProjectFuture Creation Science Division

Beauty patch development

$ 1.5 Million 2015.07~2017.06

Social problem solving technology development

Future Creation Science DivisionKorea Research

Foundation

Insulin needle development

$ 0.2 Million 2015.11~2017.11

Private investment-led technology start-up support

Small and Medium Business

Administration

Micro type patch development

$ 0.5 Million 2016.12~2018.12

Projects

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JUVIC

Ready for beauty patch for production

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JUVIC

Insulin microneedles

Hollow microneedles

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Smart tdiagnosis patchPainless anesthesia patch

Pharmaceutical Patch (Insulin and vaccine) Tuberculosis Patch

Dissolving microneedles

High efficiency and stability of biopharmaceuticals

Alopecia patech

JUVIC

Order from cosmetic partner

Beauty patch

production

Early business model: OEM/ODM for cosmetics

OEM/ODM Business

A

CollaborationMedicalpatch

production

Long term business: Medical

Our primary business target is to develop and commercialize dissolving microneedle beauty products and medical products in long term.

JUVIC

Lead in the Next GenerationMedical & Cosmetics Field

CosmeticsVaccination

PharmaceuticsNo.1 Bio & Pharma Technology World best drug delivery & 

microneedle Technology

JUVIC

Thank You

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JUVIC

Various beauty / medical patches and smart touch patches for diagnosis based on our novel fabrication technique

Cosmetics patch

Alopecia treatment

마이크로구조체Micro‐structure

Micro-injector

Microfluidics chip

ImplantableMicro-capsule

Medical patch

Controlled release Bio

Patch

Painless needles

Diagnostic systems

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JUVIC

We are planning to enter biopharmaceutical industry in near future.

Polymer biopharmaceutical technology

High efficiency and stability of biopharmaceuticals

Potential of delivering lipophilic drugs (arthritis etc.

Maximization effect of anti-metabolism

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polymer

Drug

No activity loss during fabrication

Fabrication

Drug encapsulating microneedle

JUVIC

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Microneedle types

JUVIC

Based on the target site, Microneedles are fabricated in solid, hollow and dissolving types.

SOLID HOLLOW DISSOLVING

Drugs are coated over the outer layer of microneedle

Drugs are delivered by creating channels into skin

Delivers liquid drugs via hollow channels

Dissolves inside the skin upon penetration and releases the encapsulated drug

JUVIC

Currently, microneedle fabrication technologies are focused on cosmetics field. Our manufacturing technology can be extended to medical field.

From cosmetics to medical field

Competitors

Comparison Our technology Local competitorsInternational competitors

Technology Centrifugal lithography DAB Micromolding Micromolding

Company Juvic AEndo derma, Wellage,

other companiesGeorgia tech

Cos medi

Fabrication time Less than 10 min Less than 10 min Over 3 hours

Manufacturing

process

2 stepsDispensing > Fabrication

3 stepsDispensing > drawing > air

blow

More than 3 stepsMold fabrication > Substanse insertion >

centrifuge > drying > separation

Target drugUnstable protein drugscan be utilized

Mainly applicable to small molecule chemicals and is difficult to applybiopharmaceuticals due to fabrication temperature and air drying.

Microneedle fabrication pattern

Flexible Micro mold should be re-designed

Technologydevelopment time

2014 10 2010 4 2006 1 2002 1

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JUVIC

We have developed biodegradable micro-fabrication technology using Centrifugal Lithography and also developed an applicator technology that can deliver various drugs such as water-soluble / lipid-free with high efficiency.

Main elements of dissolving microneedle delivery systems

Drug Loading Fabrication Application

Capable of loading all sort of substances

Scalability of drugs No activity loss High efficiency

2 related patents applied

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2 related patents applied

2 related patents applied

Capability of fabrication in short

time and at low temperature

High delivery efficiency

JUVIC

Contents

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JUVIC

Through a variety of applicator technologies, we can effectively deliver encapsulated substances to the target site.

Pharmaceutical Patch (Insulin)

Painless anesthesia patch

Tuberculosis Patch22

Film

Microneedle

Sticky

Microneedle

JUVIC

Juvic has developed an innovative polymer system that can mix lipid soluble drugs (more than 50% of drugs) in microneedles.

Traditional microneedles were not capable of encapsulating lipid soluble drugs

Innovative polymer systemCapable of encapsulating lipid soluble drugs

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JUVIC

Dissolving microneedles fabricated via centrifugal lithography showed lower drug activity loss compared with other manufacturing processes (such as DAB)

Activity of EGF Activity of Ascorbic acid

Comparison of centrifugal lithography and DAB fabrication methods

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JUVIC

Microneedle applicator device

Microlancer shooting device

Alopecia treatment

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JUVIC

Juvic is a start up company founded in October 2015

2016.12Selected for Small and Medium Business Administration project

2016.05Transferred 45 patents related to microneedles from Yonsei University

2016.05.Awarded the 1st Prize of startup at Yonsei University

2015.11.Selected for social problem solving technology development project

2015.10.Founded Juvic

2015.07.Selected for new industrial project

Company Juvic, Inc.

Representative Hyungil Jung, Junbae Kim

Founded on 2015.10.

AddressSeoul, Yonsei University, Engineering Building

Investment 204 Million won (2017.02)

Main ownersHyungil JungYonsei University, etc.

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Government Project

JUVIC

Based on our innovative biodegradable micro-fabrication technology, we have developed a beauty patch using lab scale pilot equipment.

Centrifugal Lithography Lab-Scale Pilot

Our technology

Cosmetic patch fabrication

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JUVICII. 기술개발 준비현황(창업팀)

28

• 논문 게재 및 연구결과를 45 건의 특허로 권리화, 기술권리를 확보함.

• 마이크로니들 저온 제작 관련 핵심 특허를 자체 보유하고 있으며,

• 보유 특허를 통한 미세돌기 스킨케어 시스템을 이용한 셀프 필러 제품 구현 가능함.

• IP컨설팅 수행을 통해 기존 지식재산권과 침해여부 분석 완료했으며,

• 연세대학교 산학협력단을 통한 기술 유출 방지대책 마련 완료함.

<마이크로니들 관련 핵심특허 보유> <특허분석 수행>

JUVICII. 기술개발 준비현황(창업팀)

29

주빅 공동대표이사 정형일

1993 연세대학교 졸업

1995 연세대학교 식품공학 석사

2002 미 코넬대학교 생명공학 박사

2004~현재 연세대학교 생명공학과 교수

2015~현재 연세대학교 최초 교원창업기업 주식회사 주빅 설립

미용 및 의약품 경피전달체 기술관련 원천기술 및 특허 다수 보유

성공적 기술이전 (총 7건) 및 사업화 (총 2건) 이력 보유

미래창조과학부장관우수 기술사업화 성과

표창장 수상

미래융합의료기기개발(한국보건산업진흥원)GMP 인증 및 사업화

서울전략산업지원사업(서울산업통상진흥원)

화장품 패치 사업화 및 수출사업화 컨설팅 수행

JUVIC

국책과제 수행기관 (벤처기업) 경영 총괄 (3개사)

II. 기술개발 준비현황(창업팀)

30

주빅 공동대표이사 김준배

1996 연세대학교 졸업

2000 미 퍼듀대학교 경영학과 석사

2004 KTB 네트워크 투자심사역

2010 셀루메드 CFO

2012 코렌텍 CFO

2016~현재 연세대학교 최초 교원창업기업 주식회사 주빅 공동대표

국책과제 수행 벤처기업 경영, 내부통제 시스템 구축 및 운영 경험 보유

재무/회계/자금 등내부통제 시스템 구축 및 운영

JUVICII. 기술개발 준비현황(창업팀)

31

• 논문 게재 및 연구결과를 45 건의 특허로 권리화, 기술권리를 확보함.

• 마이크로니들 저온 제작 관련 핵심 특허를 자체 보유하고 있으며,

• 보유 특허를 통한 미세돌기 스킨케어 시스템을 이용한 셀프 필러 제품 구현 가능함.

• IP컨설팅 수행을 통해 기존 지식재산권과 침해여부 분석 완료했으며,

• 연세대학교 산학협력단을 통한 기술 유출 방지대책 마련 완료함.

<마이크로니들 관련 핵심특허 보유> <특허분석 수행>

JUVICII. 기술개발 준비현황(창업팀)

32

주빅 공동대표이사 정형일

1993 연세대학교 졸업

1995 연세대학교 식품공학 석사

2002 미 코넬대학교 생명공학 박사

2004~현재 연세대학교 생명공학과 교수

2015~현재 연세대학교 최초 교원창업기업 주식회사 주빅 설립

미용 및 의약품 경피전달체 기술관련 원천기술 및 특허 다수 보유

성공적 기술이전 (총 7건) 및 사업화 (총 2건) 이력 보유

미래창조과학부장관우수 기술사업화 성과

표창장 수상

미래융합의료기기개발(한국보건산업진흥원)GMP 인증 및 사업화

서울전략산업지원사업(서울산업통상진흥원)

화장품 패치 사업화 및 수출사업화 컨설팅 수행

JUVIC

국책과제 수행기관 (벤처기업) 경영 총괄 (3개사)

II. 기술개발 준비현황(창업팀)

33

주빅 공동대표이사 김준배

1996 연세대학교 졸업

2000 미 퍼듀대학교 경영학과 석사

2004 KTB 네트워크 투자심사역

2010 셀루메드 CFO

2012 코렌텍 CFO

2016~현재 연세대학교 최초 교원창업기업 주식회사 주빅 공동대표

국책과제 수행 벤처기업 경영, 내부통제 시스템 구축 및 운영 경험 보유

재무/회계/자금 등내부통제 시스템 구축 및 운영