21st Annual ISMRM Scientific

Meeting and Exhibition 2013

Discovery, Innovation &

Application - Advancing MR for

Improved Health

Salt Lake City, Utah, USA

20-26 April 2013

Table of Contents and Author Index

ISBN: 978-1-62993-102-9

ISSN: 1545-4428

TABLE OF CONTENTS

VOLUME 1

Optimization of Diffusion-Weighted Imaging for Body Applications 1

Dow-Mu Koh

Making the Most of3T for Body MRI 3

Shreyas S. Vasanawala

MRCP: Techniques & Pitfalls 4

David J. Lomas

Quantification of Diffuse Liver Disease Using MRI 5

Scott B. Reeder

Cirrhosis & Lesion Characterization at MR Imaging 8

ShahidM. Hussain

The Post-Treatment Liver 10

lhab R. Kamel

Imaging Algorithms for Adrenal Lesion Characterization 11

Hero K. Hussain

Renal Mass Characterization 13

Ivan Pedrosa

Functional MRI ofthe Kidney 15

Diego R. Martin

Pelvic Floor Imaging 17

KatarzynaJ. Mactira

Prostate Carcinoma: Case Studies 19

Masoom A. Haider

Tumor Metabolism 21

Kevin M. Brindle

Tumor Physiology 26

Michal Neeman

Tumor 'Omics' 27

John R. GriffithsMR in Cancer Cell Models 31

Franca Podo

MRI/MRS in Animal Models 33

Harish Poptani

Tumor Lipid Metabolism 34

Kristine Glunde

Tumor Energy Metabolism 37

Klaas Nicolay

pH in Cancer 39

Robert J. Gillies

Molecular Imaging in Cancer 40

Dmitri Artemov

Tumor Vasculature & Perfusion: Metabolic MRI 41

Charles S. Springer Jr.

Novel Contrast: CEST, Multinuclear 42

Michael T. McMahon

Cancer Treatment Response 43

Sabrina M. Ronen

ASL: Measurement 47

Maria A. Fernandez-Seara

ASL: Single Subject & Group Analysis, Including Live Demo 48

MichaelA. Chappell

ASL: Applications: Clinical, Pharma, Cognitive Neuroscience, etc 49

John A. Detre

Cross-over: Measuring Tracer Extravasation with ASL & DCE 50

Keith St. Lawrence

DCE: Measurement 51

David J. Collins

DCE Post-Processing: What Model to Use? 55

Lucy E. Kershaw

Cross-Over: Measuring the Arterial Input Function in DCE & DCS-MRI 56

Anders GarpebringDSC: Post-Processing, Including Live Demo 58

Ona Wu

What's Normal? Accounting for Population Variability 59

Guido Gerig

Drawing A Line: Multi-Variate Classification 61

Janaina Mourao-Miranda

From Group Analysis to Individual Studies: Statistical Considerations 63

Jeanette A. Mumford

Pre-Surgical Planning: Movement, Language & the Power of Localization 64

Susan Y. Bookheimer

Spatial Imaging Patterns in AD & Its Prodromal Stages Identified via Pattern Recognition Methods 66

Christos Davalzikos

Single-Subject Neuroimaging / Reliability ofMR in Psychiatric Disorders 67

John D. Port

Stroke & The Mytl. of Quantitation 68

Greg Zaharchuk

The Brain Stress Test 69

Richard B. Buxton

Real-Time fMRI, Brain States & Biofeedback 71

Xiaoping P. ffu

MRI in the Courtroom 72

Teneille R. Brown

Wrist Ligament Pathology: Diagnosis & Pitfalls 73

Kathryn J. Stevens

Glenoid Labral Tear & Normal Variation 74

Lynne S. Steinbach

What is the Rotator Interval, & Why Is It Important? 77

Michael J. Tuite

Bone Marrow Edema: Injury Patterns 78

Christine Chung

Challenges in Diagnosing Meniscal Tear in the Knee 79

Nancy M. Major

Posterolateral Corner: "The Dark Side of the Knee" 81

Tetyana A. Gorbachova

Diagnosing Hip Labral Tear: Impingement & Dysplasia 82

John A. Carrino

OCD: What Is It & How Do I Describe It? 85

Miriam A. Bredella

Optimizing MRI for Evaluation of Cartilage Injury 86

Douglas W. Goodwin

Athletic Pubalgia: The Sportsman's "Non-Hernia" 87

Adam C. Zoga

Osteomyelitis in Diabetic Feet: Can You Be Confident? 90

Sandra L. Moore

Task-Based BOLD fMRI for Presurgical Brain Mapping 93

Christoph Stippich

Resting State Functional Connectivity fMRI for Presurgical Brain Mapping 95

JoshuaS. Shimony

Diffusion Tractography: Technical Considerations for White Matter Mapping 96

Lauren J. O'Donnell

Intraoperative DTI White Matter Mapping: Neurosurgical Perspective 97

Christopher Nimsky

DTI vs. HARDI for Presurgical FiberTracking ofthe Motor Pathways 99

Jeffery I. Berman

Clinical Value of Mapping the Language Network with MR Diffusion Tractography 100

Alberto Bizzi

Spinal Cord Imaging: Diffusion & Ultra-High Field 110

Julien Cohen-Adad

IT & Diffusion Imaging of the Cervical Spinal Cord 111

Eric E. Sigmund

Functional MR Imaging of the Spinal Cord 112

Patrick W. Stroman

Spinal Cord DTI: Applications to Multiple Sclerosis 113

DanielS. Reich

Clinical Spinal Cord Imaging: Connecting Emerging MRJ Technologies to Unmet Clinical Needs 114

Jonathan A. D. Farrell

Imaging Correlates of Spinal Cord Atrophy 115

GovindNair

Overview of the MRI System 117

Paul R. Harvey

MRJ Magnets - Design and Construction 118

Adrian Thomas

Siting the System 119

Stuart Clare

Shimming: Fields, Coils & Control 120

Christoph Juchem

Gradient Systems 126

Michaels. Poole

Field Monitoring & System Calibration 129

Christoph Barmet

Overview of Device Interactions 130

Gregor Schaefers

kHz (Gradient) Interactions 131

Blaine A. Chronik

Modeling Low Frequency Interactions 132

Stuart R. Crazier

MRI Transmitter Amplifier Systems 133

Greig C. Scott

Low Noise Amplifiers and Receive Chain Architectures for MRI Systems 134

Stephan Biber

MRI Console Electronics 135

Katsumi Kose

Quantum Mechanical Description ofNMR - From Wave Function to Bloch Equation 136

Michael H. Buonocore

Application of Quantum Mechanics & Statistical Mechanics: Equilibrium Magnetization, Relaxation & DensityMatrix 141

Adam W. Anderson

Practical Use of Multiple Quantum Coherences in Spectral Editing & 2D NMR 142

Robin A. De Graaf

From Bloch Equation to MR contrasts: Relaxation & Physical Bases of Tissue Contrast 146

John C. Gore

Other Contrast: Polarization Transfer, Chemical Exchange & Magnetization Transfer 147

PennyAnne Gowland

Bloch Equation in the Rotating Frame, Multidimensional Excitation 149

V. Andrew Stenger

Bloch-Torrey Equation & Diffusion Imaging (DWI, DTI, q-Space Imaging) 150

Jennifer A. McNab

Maxwell Equations & EM Modeling 154

FrankEngelke, Armin Purea

Static Magnetic Field: From Magnetic Susceptibility to Magnetic Field (in)Homogeneity and Back 155

Jose P. MarquesThe Gradient System - Understanding Gradients from an EM Perspective: (Gradient Linearity, Eddy Currents,Maxwell Terms & Peripheral Nerve Stimulation) 159

FranzSchmitt

RF Field Generation, Coupling, Standing Wave Transmission 172

David O. Brunner

RF Field Generation: Bl Field Non-Uniformity & SAR 173

Brian K. Rtttt

Bl-Shimming & Parallel Transmission 174

Ulrich Katscher

The Reciprocity Principle in NMR Reception 175

James TroppThe BOLD Effect & Its Use for Detecting Brain Activity 179

Clarisse I. Mark

Acquisition, Reconstruction & Artefacts 183

Hans Hoogduin

Data Analysis Basics 185

Robert L. Barry

fMRI in Basic & Clinical Neuroscience 186

Beau M. Ances

Neurovascular Coupling & Quantitation 187

Anna Devor

fMRI: From Basic to Intermediate Brain Connectivity. Pushing Temporal & Spatial Resolution 188

Pierre Levan

Optical Measurements in Functional Neuroimaging 189

Joseph P. Culver

Data Mash-Up: ERPs, EEG/MEG & Neurochemistry 190

Matthew J. Brookes

From Diffusion Weighting to the Diffusion Tensor Indices 191

GarethJ. Barker

Advanced Models - Ball & Stick, Multi-Tensor, PASMRI & Etc 192

Noam Shemesh

q-Space & Microstructure 196

Yaniv Assaf

Single Subject Diffusion Analysis - ROI, Histogram, Tractography 197

Mara Cercignani

Distortion Correction & Registration 198

Philip Cook, James Gee

Group Studies of Diffusion Data - Cross Sectional & Longitudinal Challenges 201

Stephen M. Smith

Basic Relaxation Mechanisms & Contrast Agent Design 202A. Dean Sherry

Agent Synthesis and Functionalization: From Small Molecules to Nanoparticles 204

Hut Mao

Switching & Sensing: The Design and Application of Responsive MRI Contrast Agents for Molecular Imaging 205

Mark D. Paget

Targeting Agents 207

David P. Cormode

Toxicity 208Erik M. Shapiro

Theranostic Probes for siRNA & MicroRNA Therapies 209Anna V. Moore

Technical Challenges to Detection 210

Peter M. Jakob

Applications: Translational Challenges and Opportunities for Molecular MR Imaging 211

ChristopherC. Quarles

Cell Delivery 212

JeffW. M. Bultc. AravindArepally

Specialty Area: Molecular & Cellular Imaging: From Bench to the Bed 213

Zahi A. Fayad

Rising PSA: Is There A Cancer? 218

Jurgen J. Fiitterer

Cirrhotic Liver: What Is That Nodule? 220Claude B. Sirlin

Characterization ofCystic Abdominal Lesions 221

Jay P. Heiken

Liver Lesions in Cancer Patients: What Are They? 222

Jeong Min Lee

Incidental Adnexal Masses in Cancer Patients: Act, Ignore or Follow? 225

Elizabeth A. Sadowski

Breast Cancer Response to NAC: How Reliable Is It? 226

Nolo M. Hyllon

Bone Metastases Response to Therapy: MRI Versus Nuclear Medicine 228Christina Messiou

Measuring Response to Novel Therapies: Thinking Differently 229Mark Rosen

Rising PSA in the Treated Prostate Gland 231

Aytekin Oto

Pain in the Treated Pelvis 232

Yuliya Lakhman

The Role of Biological MR Imaging in the Treatment of Head & Neck Cancer 233Sitresh Mukherji

New Developments in MR Hardware 236Boris R. Keil

New Sequences & Techniques 238

Krishna S. NayakParallel Acquisition & Compressed Sensing 239

Sebastian Ko2erke

The Evaluation of Cardiac Function - Unmet Needs 245Dara L. Kraitchman

Techniques to Image Cardiac Function 246Alistair A. Young

Research Promises: What Can We Expect in the Future? 247

Nael F. Osman

Technical Foundations: How is It Done? 249Michael Jerosch-Herold

Research Promises: What Can We Expect in the Future? 254

Craig H. Meyer

Clinical Needs: What Do We Want to See? 258

David E. Sosnovik

Technical Foundations: How is It Done? - Simonetti 260Orlando P. Simonetti

Research Promises: What Can We Expect in the Future? 264Gustav J. Strijkers

Clinical Needs: What Do We Want to See? 267MichaelD. Hope

Technical Foundations: How is It Done? 297Jos J. M. Westenberg

Research Promises: What Can We Expect in the Future? 299Oliver Wieben

Non-Contrast-Enhanced MRA 300Vivian S. Lee

Not So Fast: Recent Advances in CE-MRA 307Vlrike I. Attenberger

Best of Both Worlds 309

Jeffrey H. Maki

The Value of CMR Over Other Modalities in Clinical Trials 310Chun Yuan

Prognostic Value of CMR Versus Traditional Risk Factors 312DavidA. Bluemke, AdityaJain

Fluorine-19 318Shelton D. Caruthers

Carbon-13 Imaging in the Heart 319Charles H. Cunningham

Recent Innovations in Cardiac MR: MR-PET 321

Timothy G. Reese

PET-Instrumentation 101 322William W. Moses

Tracer 101 323Frederick T. Chin

PET-MR Hardware 101 324

Craig Levin

PET-MR in Drug Research 325Alexander J. S. De Crespigny

PET-MR in Oncology 326Nina F. Schwenzer

PET-MR in Neuro 327

Ciprian Calana

Body PET-MR 328Alexander S. R. Guimaraes

Cardio-Pulmonary MR-PET 331Ron Blankslein

Diffusion MRI in the Heart 332Choukri Mekkaoui

Skeletal Muscle 334John S. Thornton

Abdomen/Pelvis 338Thomas L. Chenevert

Breast 340Savannah C. Par/ridge

Spinal Cord/Nerve Roots 342

Jurgen Finsterbusch

Intervertebral Discs/Cartilage 343Jose Maria G. Raya

Post Mortem Brain 344Tim B. Dyrby

2D versus 3D Acquisition Strategies 345

Stefan Skare

Developmental Neuroanatomy 348OritA. Glenn

In Part from "Magnetic Resonance Imaging's Role in the Care of the Infant at Risk for Brain Injury" 349Petra S. Hiippi, Gregory A. Lodygensky, Caroline Menache

Neuroimaging ofNeonatal Seizures 372

Thierry A. G. M. Huisman

CNS Infections 373

Niranjan Khandelwal

Pediatric Inflammatory Disorders 375Ashok Panigrahy

Pediatric Neuroimaging in Metabolic Disorders 376C. C. Tchoyoson Lim

From CSF Pulsation to MR Measurement of ICP: Methodology & Potential Applications 377

Noam Alperin

CSF Physiology & Its Relationship to ICP 378

MarkE. Wagshul

Beyond 4D MRA 381

Patrick A. Turski

Normal Pressure Hydrocephalus 383

William G. Bradley Jr.

Geriatric Neuroimaging: White Matter Diseases of Aging 384

Maria A. Rocca

Differential Diagnosis of Neurodegenerative Disorders 388

Marco EssigCircuit & Transmission Lines 390

Scott B. KingVolume & Surface Coils 391

Ed B. BoskampMulti-Tuned Coils 392

Dennis W. J. Klomp, Peter R. Luiten

Receive Arrays 395

Steven M. Wright

Transmit Arrays 396

Mark E. Ladd

RF Modeling 397

Astrid L. H. M. Van Lier

Cavity Resonators - Theory & Possibilities for MRI 398

Andrew G Webb

Asymmetric Coils & Travelling Waves 404

Nicola F. De Zanche

Construction ofRX Arrays 407

Boris R. Keil

RF Pulses Designs: From Basics to the State-of-the-Art 417

Adam B. Kerr

Gradients: What Can They Do? 418

Chen Lin

Dealing with Motion: Gating, Triggering & Sampling 419

Christopher J. Hardy

Pulse Sequence Modules I (IR, DE, Spatial SAT & Chem SAT) 420

Graeme C. McKinnon

Pulse Sequence Modules II (Tagging, Labeling, Diffusion Sensitization & MT) 421

Eric C. WongFlow Contrast without Using Exogenous Agent 426

Yiping P. Du

Echo-Train Pulse Sequences: EPI, RARE & Beyond 428

David C. Alsop

Non-Cartesian k-Space Sampling 429

James G. Pipe

Spoiled & Balanced Gradient-Echo Sequences 430

Klaus Scheffler

Excitation k-Space and uTE MRI 434

John M. PolityParallel Image Reconstruction 435

Mark A. Griswold

Phase-sensitive Image Reconstruction 436

Qing-San Xiang

MR Safety: Where Do the Risks Come From? 438

Harold Kugel

Planning an MR Suite: What Can Be Done To Ensure MR Safety? 440

EmanuelKanal

Screening the Patient: How to Deal with the Individual Subject 444Anne Marie Sawyer

High Field MRI: What Are the Special Safety Risks at Higher Fields? 451

Richard W. Bowtell

Contrast Agent Use in the Age of NSF 453

Henrik Michaely

MR Safety Testing of Devices: How to Separate the Good From the Bad & the Ugly 454

Roger LuechingerMRI Safety Events: Lessons Learned 455

Robert E. Watson

Task-Less fMRI: The Phenomenon of Intrinsic Signal Fluctuations 456

Catherine E. Chang

Connectomics: Panellation & Network Analysis Methods 457

Gael VaroqitatLXDiseases ofConnectivity 459

Fruncioso Xavier Caslellanos

Connectivity Studies in Large Populations: Towards Defining Disease Mechanisms & Risk 460Paul M. Matthews

Current Limitations, Pitfalls & Criticisms 461

Gael Varoquaux

0001. Surface Coils N/A

Joseph J. H. Ackerman

0002. Inversion Recovery & Early Contrast Studies in the Brain: A Brief History 463

Ian R. Young

0003. Contrast MR Angiography N/A

MartinR. Prince

0004. Excitation K-Space & uTE MRI 466

John M. Pauly0005. FSE (RARE, TSE,...) 467

Jiirgen K. Hennig

0006. Regional Mapping ofGas Uptake by Red Blood Cells and Tissue in the Human Lung Using HyperpolarizedXenon-129 MRI 468

Kun Qing, Kai Ruppert, Yun Jiang, Jaime F. Mata, G Wilson Miller, Yun MichaelShim, Chengbo Wang, lulian C. Ruset, F.

William Hersman, Talissa A. Altes, John P. Mugler

0007. Dynamic Imaging ofthe Fetal Heart Using Metric Optimized Gating 469

Christopher W. Roy, Mike Seed, JoshuaF. P. Van Amerom, Bahiyah At Nqfisi, Lars Grosse-Wortmann, Shi-Joon Yoo, ChristopherK. Macgowan

0008.3D Hemodynamics in Intracranial Aneurysms: Influence of Size and Morphology 470

SusanneSchnell, Sameer A. Ansari, Parmede Vakil, Marie Wasilewski, Maria L. Carr, Michael C Hurley, Bernard R. Bendok,Hunt Batjer, Timothy J. Carroll, James C. Carr, Michael Markl

0009. Multi-Slice Cardiac Arterial Spin Labelling Using Improved Myocardial Perfusion Quantification with

Simultaneously Measured Blood Pool Input Function 471

Adrienne E. Campbell-Washburn, Hui Zhang, Bernard M. Siow. Anthony N. Price, MarkF. Lythgoe, Roger J. Ordidge, David L.

Thomas

0010. Joint K-T Reconstruction and Oversampled Spirals for Single-Shot 2D Spatial/1D Spectral Imaging of l5CDynamics 472

Jeremy W. Gordon, David J. Niles, Sean B. Fain, Kevin M. Johnson

0011. A New Approach to Shimming: The Dynamically Controlled Adaptive Current Network 473

Chad Tyler Harris, William B. Handler, Blaine A. Chronik

0012. Reduced-FOV Imaging with Excitation Using Nonlinear Gradient Magnetic Fields (ENiGMa) 474

Emre Kopanoglu, Ergin Atalar, Robert ToddConstable

0013. Ultrafast Single Shot Imaging with Rotating Nonlinear Fields 475

Gigi Galiana, Robert Todd Constable

0014. A 3-Axis Phase Gradient Array for RF Encoded MRI Using the TRASE Method 476

Jonathan C. Sharp, Qunli Deng, Scott B. King, Vyacheslav Volotovskyy, Boguslaw Tomanek

0015. Shear Wave Imaging by Using Bi Gradients 477

Esra Turk, YusufZiyaIder, ArifSanli Ergun, TanerDemir, Ergin Atalar

0016. 3D Imaging with Multidimensional Nonlinear Encoding 478

Maxim Zaitsev, Sebastian Littin, Anna M. Welz, FengJia, Chris A. Cocosco, Andre*' Dewdney. Gerrit Schuttz. Jiirgen Hennig

0017. MRI by Steering Resonance Through Space 479

AngelaLynn Styczynski Snyder, Curtis Andrew Corum, Steen Moeller, Nathaniel J. Powell, Michael Garwood

0018. MR Fingerprinting: Rapid Simultaneous Quantification ofTl, T2, Proton Density and Off-Resonance Usinga Spiral Trajectory 480

Dan Ma, Vikas Gulani, Nicole Seiberlich, Jeffrey Duerk, Mark A. Griswold

0019. MR Fingerprinting Using Spiral QUEST 481

YunJiang, Dan Ma, Renate Jerecic, Vikas Gulani, Nicole Seiberlich, Jeffrey Durek, Mark A. Griswold

0020. Overhauser Enhanced MR Elastography at Very Low Field 482

Najat Satameh, MathieuSarracanie, Brandon Dean Armstrong, ArnaudComment, Matthew S. Rosen

0021. Driver-Free Assessment ofLiver Stiffness Using Fast Strain-Encoded (FSENC) MRI 483

AhmedA. Harouni, Ahmed M. Gharib, Nael F. Osman. Roderic I. Pettigrew, KhaledZ. Abd-Elmoniem

0022. Renal Diffusion and Perfusion in Cardiorenal Syndrome 484

Nur Farhayu Omar, Eleanor F. Cox, Tobias Breidthardt. fain B. Squire. Aghogho Odudu, Mohamed Torek Eldehni, Chris

Mclntyre, Susan T. Francis

0023. Susceptibility Tensor Imaging of the Renal Tubule 485

Luke Xie, Russell Dibb, Wei Li, Chunlei Liu, G. Allan Johnson

0024. Changes in Intrarenal Oxygenation as Evaluated by BOLD MRI in a Rat Biliary Obstruction Model 486

Mingshu Yang, Minji, Bin Yang, Li Wang, Chunmei Xia, Lixia Yang, Zhongwei Qiao, EdX. Wu

0025. Effects of an X-Ray Contrast Medium Administration on Renal T2* and T2 487

Andreas Pohlmann, Karen Arakelyan, Kathleen Cantow, Jan Hentschel, Bert Flemming. MechthildLadwig, Erdmann Seeliger,Thoralf Niendorf

0026. Evaluation ofNephrotoxicity of Iso- Versus Low-Osmolar Iodine Contrast Media by BOLD and Diffusion-

Weighted MR Imaging 488

Yuan-Cheng Wang, Shenghong Ju. Gao-Jun Teng

0027. High Temporal Resolution Mouse Renal Blood Flow (RBF) Imaging with Pseudo-Continuous ASL (PCASL)at Very High Field 489

Guillaume Duhamel, Valentin Prevost, Olivier M. Girard, Virginie Callot, Patrick J. Cozzone

0028. Assessment of Experimental Acute Kidney Injury by Fast Interleaved Monitoring ofT2* and T2 490

Andreas Pohlmann, Jan Hentschel. Mandy Fechner, Uwe Hoff Gordana Bubalo. Karen Arakelyan, Kathleen Canlow, Erdmann

Seeliger. Bert Ftemming, Lajos Marko, Helmar Waiczies, Sonia Waiczies, WolfHagen Schunck, DominikN. Mueller, Duska

Dragun, ThoralfNiendorf

0029. Combination of Non-Invasive Parametric MRI and Invasive Physiological Measurements: Towards a

Hybrid and Integrated Approach for Investigation ofAcute Kidney Injury 491

Jan Hentschel, Kathleen Cantow, Andreas Pohlmann, Karen Arakelyan, Bert Flemming, Mechthild Ladwig, Erdmann Seeliger,Uwe Hoff, Pontus B. Persson, Thoralf Niendorf

0030. Feasibility of Single Breath-Hold Renal Perfusion Imaging at 7T 492

Xiufeng Li, Carl Snyder, Pierre-Francois VanDe Moortele. Kamil Ugurbil, Gregory J. Metzger

0031. Arterial Spin Labeling for Quantification and Monitoring of Renal Blood Flow Changes After Acute Kidney

Injury in Mice - Comparison with Histopathology and Renal Function 493

Katja Hueper, Marcel Gutberlet, DagmarHartung, Song Rong, Hermann Holier, Martin Meier, Frank Wacker, Faikah Gueler

0032. Anatomical/Axonal Basis and Plasticity of Resting-State fMRI Connectivity in an Experimental Model of

Corpus Callosum Transection 494

Iris Y. Zhou, Y. X. Liang. Russell W. Chan, Shujuan Fan. Patrick P. Gao. Joe S. Cheng, K. F. So, EdX. Wu

0033. Caffeine-Induced Reductions in the Resting-State fMRI Global Signal Reflect Increases in EEG VigilanceMeasures 495

Chi Wah Wong, Valur Olafsson, Omer Tal, Thomas Liu

0034. Clustered Spontaneous Coordinated Network Events Contribute to Functional Connectivity 496

Thomas Allan, Matthew J. Brookes, Susan T. Francis, Penelope A. Gowland

0035. Multiple Time Scale Complexity Analysis of Resting State Fluctuations 497

Robert Smith

0036. Finite Number of Brain Network Configurations Revealed from Time-Varying Connectivity Assessment of

Resting State fMRI 498

Hao Jia, Xiaoping P. Hu, Gopikrishna Deshpande

0037. Investigation of the Neural Basis of the Default Mode Network Using Parallel Independent ComponentAnalysis ofSimultaneous EEG/fMRI Data 499

Sreenath Pntthviraj Kyathanahally, Nurhan Erbil, Vince D. Calhoun, Gopikrishna Deshpande

0038. Intrinsic Connectivity Network Activity Revealed by the Independent Modelling of the Primary and Post-

Stimulus Components of the BOLD Response 500

Karen J. Mullinger, Stephen D. Mayhew, Andrew P. Bagshaw, Richard W. Bowtell, Susan T. Francis

0039. Spontaneous Co-Activation Patterns ofthe Brain Revealed by Selectively Averaging Resting-State fMRI

Volumes 501

Xiao Liu, Catie Chang. Jeff H. Duyn

0040. Resting Brain Networks Revealed by Independent Component Analysis of Cerebral Blood Flow 502

Senhua Zhu, Zhuo Fang, Siyuan Hit, MarcKorczykowski, Ze Wang, John A. Detre, Hengyi Rao

0041. Resting-State fMRI at 4 Hz 503

Ying-Hua Chu, Jyrki Ahveninen, Tommi Raij, Wen-Jui Kuo, John W. Belliveau, Fa-Hsuan Lin

0042. Functional and Structural Disruption of the Precuneus Contributes to Cognitive Impairment in Pediatric

Multiple Sclerosis 504

Maria A. Rocca, Martina Absinta, Maria Pia Amato, Angelo Ghezzi, Lucia Moiola, Agnese Fiorino, Pierangelo Veggiotti,Giancarlo Comi, Massimo Filipp

0043. Impaired Regulation of the Blood Supply to the Brain in Multiple Sclerosis Measured with HypercapniaBOLD MRI 505

Yulin Ge, Hanzhang Lu, Yongxia Zhou, FengXu, IlyaKister, HinaJaggi, JosephHerbert, Robert I. Grossman

0044. Regional Hippocampal Involvement Differs Across Multiple Sclerosis Clinical Phenotypes: A Radial

Mapping MRBased Study 506

Elisabetta Pagani, Maria A. Rocca, Giulia Longoni, Vittorio Martinelli, Bruno Colombo, Andrea Falini, Giancarlo Comi, Massimo

Filippi0045. Macromolecular Proton Fraction as a New Clinical Biomarker of Demyelination in Multiple Sclerosis 507

Vasily L. Yarnykh, James D. Bowen, Alexey A. Samsonov. Pavle Repovic, AngeliMayadev, Bart P. Keogh, Beena Gangadharan,HunterR. Underbill, Kenneth R. Maravilla, Lily K. Jung Henson

0046. Spatial Patterns ofCortical Thinning in Neuromyelitis Optica: A Comparative Study with Multiple Sclerosis 508

Yaou Liu, Teng Xie, Ni Shu, Kuncheng Li, Yong He

0047. Hippocampal Magnetization Transfer Ratio and Not Hippocampal Atrophy Best Explains Memory

Dysfunction in Patients with Multiple Sclerosis 509

Mishkin Derakhshan, Gabriel Leonard, Daviad Araujo, D. Louis Collins, Douglas L. Arnold, Sridar Narayanan

0048. Regional Cortical Thickness in Relapsing Remitting Multiple Sclerosis: A Multi-Center Study 510

Ponnada A. Narayana, Koushik Govindarajan, Priya Gael, Sushmita Datta, John A. Lincoln, Stacy S. Cofteld, Gary R. Cutter, Fred

D. Lublin, Jerry S. Wolinsky

0049. Magnetisation Transfer Imaging of Subpial Cortical Abnormalities in Multiple Sclerosis 511

Rebecca S. Samson, Manuel Jorge Cardoso, Nils Muhlert, Varun Sethi, Claudia Angela M. Wheeler-Kingshott, Maria A. Ron,

Sebastian Ourselin, DavidH. Miller. Declan T. Chard

0050. Impact of Macrophagic Activity on Tissue Structure in Patients Suffering from Clinically Isolated Syndrome

Suggestive of Multiple Sclerosis: A Multicentric USPIO Enhancement Study at 3T 512

Adil Maarouf Jean Chrislophe Ferre. Wafaa Zaaraoui, Elise Bannier, Christian Barillot, Isabelle Berry, Gilles Edan, Damien

Galanaud, Jean Pelletier, Chrislophe Portefaix, Ayman Tourbah, Jean-Philippe Ranjava, Bertrand Audoin

0051. Correlations Between Corpus Callosal Myelin Water Fraction and Measures ofTranscallosal Inhibition in

Multiple Sclerosis Patients on Glatiramer Acetate Treatment 513Eric Y. Zhao. Irene Vavasour. Marjan Zakeri, Michael Borich. Cornelia Laule. Anthony L. Traboulsee. David K. B. Li. Lara Boyd,Alex L. Mackay

0052. The Human Connectome Project: Advances in Diffusion MRI Acquisition and Preprocessing 314Stamatios N. Sotiropoulos, Saad Jbabdi, JunqianXu. Jesper L. Andersson. Sleen Moeller, Edward J. Auerbach. Mat/hew F.

Glasser, DavidFeinberg, Christophe Lenglet. David C. Van Essen. Kamil Ugurbil, Timothy E. J. Behrens, Essa S. Yacoub

0053. Combining ZOOPPA and Blipped CAIPIRINHA for Highly Accelerated Diffusion Weighted Imaging at 7T

and 3T 515

Cornelius Eichner, Kawin Setsompop, Peter J. Koopmans, Alfred Anwander, RalfLutzkendorf, Steven F. Cauley, Himanshu Bhal.

David G. Norris, Robert Turner. Lawrence L. Wald, Robin Martin Heidemann

0054. 3D Multi-Slab Diffusion-Weighted Readout-Segmented Echo-Planar Imaging with Real-Time Cardiac-

Reordered K-Space Acquisition 516

Robert Frost, KarlaL. Miller, DavidA. Porter. Rob H. N. Tijssen, Peter Jezzard

0055. Accelerating Data Acquisition for Reversed-Gradient Distortion Correction in Diffusion MRI: A

Constrained Reconstruction Approach 517

Chilresh Bhushan, AnandA. Joshi, Richard M. Leahy. Justin P. Haldar

0056. High-Resolution Diffusion Weighted MRI Enabled by Multi-Shot EPI with Multiplexed Sensitivity-Encoding 518Nan-Kuei Chen, Arnaud Guidon, Hing-Chiu Chang, Allen W. Song

0057. Tilted 2D RF Excitation with Extended Slice Coverage for High-Resolution Reduced-FOV DWI 519Suchandrima Banerjee, Emine U. Saritas, GerdMelkus, Ajit Shankaranarayanan

0058. Fast DSI Reconstruction with Trained Dictionaries 520Berkin Bilgic, Itthi Chatnuntawech, Kawin Setsompop, Stephen F. Cauley, Lawrence L. Wald, Elfar Adalsteinsson

0059. Optimal Acquisition Protocol for White Matter Fiber Orientation Mapping Using Generalized CSA-ODF

Reconstruction 521Amith J. Kamath, /man Aganj, Junqian Xu, Essa S. Yacoub, Kamil Ugurbil, Guillermo Sapiro, ChristopheLenglet

0060. A Comparison Between Double-PFG MRI and DTI in ex Vivo Rat Brain 522Tuukka Miettinen, Alejandro Sierra, Teemu Laitinen, Juhana Sorvari, Olli Grohn

0061. Oscillating Gradient Spin-Echo (OGSE) Diffusion Tensor Imaging ofthe Human Brain 523

CoreyAllan Baron, Christian Beaulieu

The Physics ofMRI - Basic Spin Gymnastics 524

Walter Kucharczyk, Donald B. Plewes

K-Space 536Kevin M. Koch

Shoulder: Sources of Impingement 538Michael P. Recht

Hip: Femoral-Acetabular & Ischiofemoral Impingement 539Julia Crim

MRI ofAnkle Impingement Syndromes 541

James M. Linklater

Nerve Impingement Around the Body 542

Luis S. Beltran

Surgical Perspective: Neurosurgical Approach to Brain Tumors 543

Randy L. Jensen

The Perspective ofthe Neuro-oncologist in Brain Tumor Management after Surgery: What are the Questions &How can MR ImagingHelp? 544

Howard Colman

Addressing the Oncologist's Concerns with MR Imaging: Now & Future 545

Whitney Pope

0062. A Direct Calculation of Hemodynamic Energy Loss in the Presence of Abnormal Aortic Flow 546

Alex J. Barker, Krishna C. Bandi, Julio Garcia. Pirn Van Ooij, Patrick McCarthy. James C. Carr, S Chris Malaisrie, Michael

Mark!

0063.4D Flow MRI for Non-Invasive Assessment ofMesenteric Ischemia 547

Oliver Wieben. Alejandro Roldan-Alzate. Scott B. Reeder, Mark L. Schiebler. Scott K. Nagle, Charles W. Acher, Ben Ray Landgraf.Thomas M. Grist. Christopher J. Francois

0064. New Insights in the Disagreement ofTransvalvular Mean Pressure Gradient Measured by Transthoracic

Echo-Doppler and Cardiovascular Magnetic Resonance in Patients with Aortic Stenosis 548

Julio Garcia, Romain Capoulade, Lyes Kadem, Eric Larose, Philippe Pibarot

0065. Evaluation and Validation of Pulse Wave Velocity Measurements from 2D and 4D PC MRI in Swine with

Familial Hypercholesterolemia: Initial Results 549

Andrew L. Went/and, Thomas M. Grist, Dhanansayan Shanmuganayagam, Christian G. Kmeger, Patrick E. McBride, Jennifer J.

Meudt. Jess D. Reed, Oliver Wieben

0066. High Temporal-Resolution Three-Directional Velocity Measurements in a Single Breath-Hold Using EPIand Direct Inversion 550

NingJin, Rizwan Ahmad, Yu Ding, Sven Zuehlsdorff, Orlando P. Simonetti

0067. 4D UTE Flow: A Novel 4D Ultra-Short TE Phase-Contrast MRI Technique for Assessment of Flow and

Hemodynamics 551

Mo Kadbi. Melanie S. Traughber, Peter Martin, AmirA. Amini

0068. High-Resolution, High-SNR Velocity Maps Reconstructed from Low-Resolution Fourier Velocity EncodedMRI Data 552

Vinicius De Carvalho Rispoli, Joao L. A. Carvalho

0069. Analysis ofThermal Stability of Background Phase Errors in Phase-Contrast Flow Imaging 553

Julia Busch, Signe Johanna Vannesjo, Chrisloph Barmel, Klaus P. Pruessmann, Sebastian Kozerke

0070. 4 Dimensional, Single Step Laplacian Algorithm for Phase Unwrapping in 4D MR Flow 554

MichaelLoecher, Oliver Wieben, Kevin M. Johnson

0071. Improved Excitation Fidelity in Cardiac Imaging with 2-Spoke Parallel Excitation at 7 Tesla 555

Sebastian Schmitler, Lance Delabarre, Xiaoping Wu, Andreas Creiser, Dingxin Wang, Kami! Ugurbil, Pierre-Francois Van De

Moortele

0072. Improvement in B1+ Homogeneity of3T Cardiac MRI in Swine with Dual-Source Parallel RF Excitation 556

Daniel A. Herzka, Haiyan Ding, Michael Schar

0073. kT - PINS RF Pulses for Low-Power Field Inhomogeneity-Compensated Multislice Excitation 557

Amy Sharma, Samantha J. Holdsworth, Rafael O'Halloran, Eric Aboussouan, Anh Tu Van, Julian R. Maclaren, Mural Aksoy,Victor Andrew Stenger, Roland Bammer, William A. Grissom

0074. Simultaneous Multi-Slice Parallel RF Excitation with In-Plane B1+ Homogenization 558

Xiaoping Wu, Sebastian Schmitler, Edward J. Auerbach, Sleen Moeller, Kamil Ugurbil, Pierre-Francois Van De Moortele

0075. Simultaneous Multi-Slice Excitation by Parallel Transmission Using a Dual-Row PTX Head Array 559

Benedikt A. Poser, Robert James Anderson, Peter Serano, Azma Mareyam, Bastien Guerin, WeiranDeng, Lawrence L. Wald,

Victor Andrew Stenger

0076. Subject- And Resource-Specific Monitoring and Proactive Management of Parallel RF Transmission 560

Cem Murat Deniz, LeeorAlon, Ryan Brown, DanielK. Sodickson, Yudong Zhu

0077. Improvement in T2-Weighted Imaging at 7T by Using K[-Points 561

Florent Eggenschwiler, Kieran O'Brien, Rolf Gruetter, Jose P. Marques

0078. Fast Reconstruction for RF Monitored Sweep Imaging with Sideband Excitation 562

David Otto Brunner, Benjamin E. Dietrich, Matteo Pavan, Klaas P. Pruessmann

0079. B|-Insensitive Slice-Selective Pseudo-Adiabatic Pulse 563

Benoit Bourassa-Moreau, Guillaume Gilbert, Gilles Beaudoin

0080. A Simple Fat Suppression Method for Accelerated and Low-SAR 3D-EPI 564

Riidiger Stirnberg, DanielBrenner, Tony Stocker, Nadim Jon Shah

0081. Multiparametric Microvascular MRI: A Cluster Approach to Characterize Glioma 565

Nicolas Coquery, Clement S. Debacker, Regine Farion, Chantal Remy. Olivier Francois, Emmanuel Luc Barbier

0082. Longitudinal Characterization ofApolipoprotein E Targeted Replacement Mice at 7 T 566

James A. Goodman, Peter Cheng-Te Chou, Zhiyong Xie, Kelly R. Bales

0083. Microscopic 3D-DTI ofTumor Cell Migration, Numerical Modeling and Two- Photon Microscopic Imaging 567

Ulysse Gimenez, Florence Appaix, Teodora-Adriana Perles-Barbacaru, Franck Mauconduit, Marie-France Nissou, Emilie

Langard, Laurent Pelletier, Francois Berger, Didier Wion, Boudewijn Van Der Sanden, ffana Lahrech

0084. Preclinical MRI Reveals Bevacizumab Mitigates Radiation Necrosis 56S

X. Jiang, John A. Engelbach, Jeremy Cates, Dinesh K. Thotala, R. E. Drzymala, D. E. Hallahan, J. H. Ackerman, Joel R. Garbow

0085. Effects ofMaternal Chlorpyrifos Exposure on Guinea Pig Neurodevelopment 569

Roger J. Mullins, Su Xu, Joseph D. Pescrille, Jacek Mamczarz, Edna Pereira, EdsonX. Albuquerque, Rao P. Gullapalli

0086. Multivoxel Proton MR Spectroscopy Reveals Subcortical Glial Response to SIV-Infection in Rhesus

Macaques 570

William E. Wu, Ke Zhang, AssafTal, Eva-Maria Ratai, Ramon Gilberto Gonzalez, OdedGonen

0087. Activity-Modulated Interhemispheric Manganese Transfer Upon Intracortical Injection 571

Shu-Juan J. Fan, Wenwen A. Han, Frank Y. Lee, Kevin C. Chan. Samantha J. Ma, EdX. Wu

0088. Decreased Functional Connectivity After Acute Cocaine Administration: A Feasibility Study ofResting-State fMRI in Awake Non-Human Primates 572

Kaundinya Gopinath, Kevin Murnane, Leonard Howell

0089. Gd-Staining Reveals the Efficacy of an Anti-AB Antibody to Decrease Amyloid Plaque Load in Vivo in a

Transgenic Mouse Model of Alzheimer's Disease 573

Mathieu DavidSantin, Thomas Debeir, Thierry Delzescaux. Anne-Sophie Herard, Caroline Cohen, Laurent Pradier, Thomas

Rooney, MarcDhenain

0090. The Dose Response of the Developing Mouse Brain After Cranial Irradiation Varies by Brain Structure 574

Lisa M. Gazdzinski. RichardJ. Alsop, Brian J. Nieman

0091. MRI-US Fused Targeted Prostate Biopsy Detects Clinically Significant Cancer in Active Surveillance

Patients Better Than 12 Core Random Biopsy with Less Than 4 Cores 575

Michael Da Rosa, Laurent Milot, Linda Sugar, Danny Vesprini, Hans Chung, Andrew Loblaw, Laurence Klotz, Masoom A. Haider

0092. Validation Study ofESUR Prostate MR Guidelines 2012: The Significance of Different Sequences of Multi-

Parameter MRI in Detection ofProstate Cancer in 106 Consecutive Patients 576

Juan Hu, He Wang, Xuedong Yang, Chengyan Wang, Rui Wang, Ge Gao, Hui Zhang, Wenchao Cai, Wei Wang, Jue Zhang,Xiaoying Wang

0093. Derivation and Comparison of Site Specific Peripheral and Transition Zone Quantitative DCE MRI LogisticRegression Models for Prostate Cancer Detection: Does Cancer Location Matter? 577

Nikolaos Dikaios. MohamedAbdAlazeez, MarkEmberton, Taiki Fujiwara, David Atkinson, Shonit Punwani

0094. Computed Diffusion-Weighted Imaging of the Prostate at3T: Impact on Image Quality and Tumor

Detection 578

Andrew B. Rosenkrantz, Nicole Hindman, Hersh Chandarana, Fang-Ming Deng, James S. Babb, Samir S. Taneja, Christian

Geppert0095. Contrast Dispersion Mapping in DCE MRI: A New Option for Prostate Cancer Detection 579

Massimo Mischi, Kyveli Kompatsiari, Tamerlan Saidov. Marc Engelbrecht, Hessel Wijkstra, Marcel Breeuwer

0096. Hybrid T2 and Diffusion Weighted MRI for Prostate Cancer Detection 580

Shiyang Wang. Yahui Peng, Milica Medved, Ambereen Yousuf. Marko Ivancevic. Ibrahim Karademir, Yulei Jiang, Tatjana Antic.

Steffen Sammel. Aytek Oto, Gregory S. Karczmar

0097. 'H MRSI of Prostate Cancer Incorporating Spermine in the Quantification, a 7 Tesla Patient Study 581

Mariska P. Lultje, Robin A. De Graaf, Catalina S. ArleagaDe Castro, Peter R. Luijlen, Marco Van Vulpen, Uulke A. Van Der

Heide, Dennis W. J. Klomp0098. Stratification of Disease Aggressiveness of Prostate Cancer Using MRSI and DWI 582

Durgesh KumarDwivedi, GirdharBora, Rajeev Kumar, Sanjay Thitlkar, Sanjay Sharma, Siddhartha D. Gupta, NaranamangalamR. Jagannathan

0099. MR Spectroscopic Imaging of Prostate Cancer: Metabolism or Morphology? 583Thiele Kobus, Jeroen Van Der Laak, Caroline Bruggink, Christina Hulsbergen-Van DeKaa, Tom W. J. Scheenen, Arend

Heerschap

0100. Planning a Boosted Radiotherapy Dose to the Dominant Intraprostatic Tumour Lesion Within the Prostate

as Defined by Multifunctional MR Parameters 584

SophieF. Riches, Geoffrey S. Payne, Nandita M. Desouza. Scott Morgan. David Dearnaley, Veronica A. Morgan, SharonL. Giles,Mike Partridge

0101. Fast Cerebral Flow Territory Mapping Using Vessel Selective Dynamic Arterial Spin Labeling 585

Xingxing Zhang, Eidrees Ghariq, Sophie Schmid, Wouter M. Teeuwisse, Andrew G. Webb, Matthias J. P. Van Osch

0102. The Use of k-Means Clustering and Bayesian Inference Framework for the Processing ofVessel-Encoded P-

CASL Images as Compared with Super-Selective P-CASL MRI 586

Nolan S. Hartkamp, Michael Helle. MichaelA. Chappell, Thomas W. Okell, ReinoudP HBokkers, Jeroen Hendrikse, Matthias J.

P. Van Osch

0103. VENTI: Venous Territory Imaging Using Remote Sensing 587

Eric Wong, Jia Guo

0104. High Temporal Resolution Sampling ofTracer Kinetic Curves Using Time Encoded PCASL with Look-

Locker Readout 588

WouterM. Teeuwisse, Sophie Schmid, Andrew G. Webb, Matthias J. P. Van Osch

0105. Time Efficient Determination ofSpin Compartments by Time Encoded Arterial Spin Labeling 589

Sophie Schmid, Wouter M. Teeuwisse, Eidrees Ghariq, Andrew Webb, Hanzhang Lu, Matthias J. P. Van Osch

0106. Assessing Intracranial Vascular Compliance Using Dynamic Arterial Spin Labeling 590

Lirong Yan, Robert Smith, Collin Liu, Emily Kilroy, Yufen Chen, Danny J. J. Wang

0107. Simultaneous Acquisition of Cerebral Blood Volume, Blood Flow and Blood Oxygenation Weighted MRI

Signals at7T 591

Steffen N. Krieger, Laurentius Huber, Gary F. Egan, Robert Turner

0108. Multi-Bolus Pulsed ASL for Improved Renal Perfusion Quantification 592

Xiang He, Serter Gumus, Ayaz Aghayev, Kyongtae TyBae

0109. Simultaneous Arterial Spin Labelling MRI and H20ls Position Emission Tomography 593

Ke Zhang, HansHerzog, Christian Filss. Thomas Fischer, Walter Sturm. Burkhard Brocke, Nadim Jon Shah

0110. Investigating White Matter Perfusion Using Optimal Sampling Strategy Arterial Spin Labeling (OSS-ASL)at 7T 594

Alexander Graeme Gardener, Peter Jezzard

Methods for Hyperpolarizing Nuclear Spins 595

Jan H. Ardenkjaer-Larsen

Methods for Fast Imaging ofHyperpolarized Nuclei 597

Charles H. Cunningham

Preclinical Metabolic Imaging (Cancer, Cardiac, Kinetic Analysis) 599

DanielM. Spielman

Cardiovascular MR Imaging: Pushing the Limits, Part 1 600

Reza NezafatWhat's New in MR Safety?- Active Implants, Device Labeling & Identification 601

William Faulkner

Occupational Exposure Limits, Magnetic Field Spatial Gradients & Their Impact on MR Safety Practices 602

Gregory C. Brown

To Scan or Not to Scan? MR Safety Decision Making & the FPO Mode 604

EmanuelKanal, Anne Marie Sawyer

Legacy Implants, MR Conditional Labeling, Conflicting Information - MR Safety Now & the Future: Is There a

Better Paradigm? N/A

Stephanie Haaf

Genetics and Molecular Biology ofAlzheimer's Disease - Who Will Benefit from this Information 608

N/a

Quantitative Neuroimaging in the Clinical Setting: Toward an Earlier and More Accurate Diagnosis of

Neurogenerative Disease 613

James Brewer

Predicting Neurodegenerative Disease with Connectomics 614

Ashish Raj

0111. The C57BL/6 Mouse Exhibits Sporadic Congenital Portosystemic Shunts 615

Cristina Cudalbu, Valerie A. McLin, Hongxia Lei, Joao M. N. Duarte, Anne-Laure Rougemont. Graziano Oldani, Sylvain Terraz,

Christian Toso, RolfGruetter

0112. Astrocyte Reactivity Is Associated with Decreased Levels of N-Acetyl-Aspartate in the Absence of

Neurodegeneneration in the Rat Brain 616

Maria-Angeles Carrillo-De Sauvage, Lucile Ben Haim, Julien Valette. Carole Escartin

0113. 7 T 'H Detects Human Brain Gutamate Concentration Changes in Response to Hypoglycemia: A Study of

Diabetic Patients with and Without Hypoglycemia Unawareness 617

Melissa Terpstra. Amir Moheet, Anjali Kumar, Lynn E. Eberly, Elizabeth Seaquist, Gulin Oz

0114. Early Increases in Glu/GIn, Tau and TCho 1H MRS Resonances in vivo, Anticipate Later ImagingRepercussions ofthe Cerebral Inflammatory Response in a Mouse Model ofLPS-Induced Endotoxemia 618

Ana Belen Martin-Recuero, Agnieszka Krzyzanowska, Pilar Lopez-Larrubia, Carlos Avendaho, Sebastian Cerdan

0115. uNa-MRI and EPT: Are Sodium Concentration and Electrical Conductivity at 298 MHz (7T) Related? 619

Astrid L. H. M. W. Van Lier. Paul W. De Bruin, Sebastian A. Aussenhofer. Peter R. Luijten, Jan J. W. Lagendijk. Cornells A. T. Van

Den Berg, Andrew G. Webb

0116. Chlorine (35Cl) MRI in Humans: CI- Alterations Do Not Correspond to Disease-Related Na* Changes 620

Armin M. Nagel, Marc-Andre Weber, Frank Lehmann-Horn, Karin Jurkat-Rott, Alexander Radbruch, Reiner Umathum, WoljhardSemmler

0117. In Vivo Cardiac 'H MRS, 31P MRS, and MRI in Mouse Models of Increased Fatty Acid Oxidation with and

Without Myocardial Lipid Accumulation 621

Desiree Abdurrachim, Jolita Ciapaite, Michel Van Weeghel, Bart Wessels, Klaas Nicolay, SanderM. Houten, Jeanine J. Prompers0118. Caloric Restriction Enhances Oxidative Brain Metabolism in Healthy Aging Detected by 'H("CJMRS 622

Ai-Ling Lin, Daniel Coman, Lihong Jiang, Douglas L. Rothman, Fahmeed Hyder0119. Rates of Human Hepatic Oxidative Metabolism Estimated in Vivo Using a Novel "C-MRS Method 623

Douglas E. Befroy, Nimit Jain, Kill Folk Pelesen, Gerald I. Shulman, Douglas L. Rothman

0120. Acetylcarnitine Turnover in Rat Skeletal Muscle Measured in Vivo Using Localized "C NMR at 14.1 T 624

Jessica A. M. Bastiaansen, Joao M. N. Duarte, ArnaudComment, Rolf Gruetter

0121. Slab Profile Encoding for Minimizing Venetian Blind Artifact in 3D Diffusion-Weighted Multislab

Acquisition 625

Anh Tu Van, MuralAksoy, SamanthaJ. Holdsworth, DanielKopeinigg, Sjoerd 8. Vos, RolandBammer

0122. Accelerated Parallel Traveling Wave MR and Compressed Sensing Using a2-Channel Transceiver Array 626

Maryam Varelh, Anita Flynn, Wei Bian, Ye Li, DanielB. Vigneron, Sarah J. Nelson, Xiaaliang Zhang0123. Separation of Two Simultaneously Encoded Slices with a Single Coil 627

Daniel B. Rowe, Andrew S. Nencka. Andrzej Jesmanowicz, James S. Hyde0124. Local Resolution Adaptation for Curved Slice Imaging 628

Hans Weber. Gerril Schullz, Daniel Gallichan, Jiirgen Hennig, MaximZaitsev

0125. Simultaneous Multi-Slice Flyback Echo Planar Imaging with Auto-Calibration 629

Kangrong Zhu, AdamKerr, John M. Pauly

0126. Automated Selection of 2D-CAIPIRINHA Kernels and Application to 3D CE-MRA 630

Paul T. Weavers, Eric A, Borisch, Stephen J. Riederer

0127. ESPIRiT Reconstruction Using Soft SENSE 631Martin decker, Patrick Virtue, Shreyas S. Vasanawala. MichaelLustig

0128. Improving K-T Auto-Calibrating Parallel Imaging for 3D Cardiac Cine MRI Using Prior-Reconstruction

Static Tissue Estimation and Elimination 632

Peng Lai, Shreyas S. Vasanawala, Atsushi Nozaki, Maggie Fung. Anja C. SBrau

0129. Iterative Trajectory Correction for Radial Projection Imaging 633Tobias Wech, Johannes Tran-Gia, Dietbert Hahn, Herbert Kdstler

0130. Calibrationless Chemical Shift Encoded Imaging Using a Time-Segmented K-Space Reconstruction 634

Samir D. Sharma, Joshua D. Trzasko, Armando Manduca

0131. A Separated Transmit-Only, Receive-Only Array for Body Imaging at 7T with Automated Tuning and

Matching Capabilities 635

Carl Snyder. Lance Delabarre. Aaron T. Hess, Chris Rodgers, Mattew Robson, J. Thomas Vaughan0132. A Novel Flexible Flex Cable Antenna (FFCA) for Foot MR Imaging 636

Hongyang Yuan, Qunzhi Chen, Yu Wang, Wenchao Cat, Xiaoying Wang, Jue Zhang, JingFang0133. Screen Printed Flexible 2-Channel Receive Coil Array 637

Joseph R. Corea, AnaClaudia Arias, Anita Flynn, Greig C. Scott, Peter Shin, MichaelLustig

0134. Development of a Catheter-Mounted Cardiac RF Coil for Temperature Imaging in Atrial Fibrillation

Treatment 638

Nelly A. Volland. Robb Merrill. J. Rock Hadley. Dennis L. Parker

0135. High-Temperature Superconducting Radiofrequency Probe for MRI Applications Operated Below AmbientPressure in a Simple Liquid-Nitrogen Cryostat 639

Simon Auguste Lambert, MariePoirier-Quinol, Jean-Chrislophe Ginefri, Luc Darrasse

0136. MR Microimaging Using a High Tc Superconducting Bulk Magnet with Compressed Sensing 640Daiki Tamada, Takashi Nakamura, KatsumiKose

0137. A Lightweight, Portable MRI Brain Scanner Based on a Rotating Halbach Magnet 641Clarissa Zimmerman Cooley, Jason P. Stockmann, Brandon Dean Armstrong, Matthew S. Rosen, Lawrence L. Wald

0138. Target Field Based RF Phase Gradient Transmit Array for 3D TRASE MRI 642Jesse Bellec, Scott B. King, Chen-YiLiu, Christopher P. Bidinosli

0139. An Open Source Mobile NMR Relaxometry Platform 643Michael Twieg, MatthewJ. Riffe, Natalia Gudino, Mark A. Griswold

0140. Magnetic Particle Imaging for Safe Angiography and Stem Cell Tracking 644Emine U. Sarilas. Patrick W. Goodwill, Justin J. Konkle, Laura R. Croft. Kuan Lu, Bo Zheng, Steven M. Conolly

0141. Aging Augments the Suppression Ratio, A MRI Biomarker of Cortical Bone Porosity 645

Yiisu/A. Bhagat, Cheng Li, Shing Chun Benny Lam, Alan C. Seifert, Mahdieh BashoorZadeh, Felix W. Wehrli

0142. Can We Assess Cortical Bone Microstructure with Magnetic Resonance Imaging? 646Won C. Bae, Reni Biswas. Shantanu Patil, Christine Chung, Darryl D. D'Lima, Graeme M. Bydder, Jiang Du

0143. The Porous System Model Suitable to Investigate the Structural Properties of the Cancellous Bone by UsingDiffusion Techniques: Validation in Calcaneus and Femoral Neck 647

Silvia Capuani

0144. Assessment ofBone Marrow Fat Fraction in the Presence of Trabecular Bone: Initial Comparison ofWater-

Fat Imaging with Single-Voxel MRS 648

Dimilrios C. Karampinos, Gerd Melkus, Thomas Baum,Jan S. Bauer, Ernst J. Rummeny, RolandKrug0145. Variation ofLamellar Layer Thickness in Human Menisci on Ultrashort Echo Time (UTE) Imaging:Correlation with Indentation Stiffness 649

Ja-Young Choi, Rem Biswas, Mike Im, Won C. Bae, Sheronda Slatum, Eric Chang, Jiang Du, Graeme M. Bydder, DarrylD.D'Lima, Christine Chung

0146. Correlation Between Quantitative Delayed Contrast-Enhancement in Meniscus and Cartilage in Knee

Osteoarthritis 650

Jasper Van Tiel, Esther Bron, Koen Bos, Stefan Klein, Max Reijman, Jan Verhaar, Gabriel Krestin, Harrie Weinans, GyulaKotek,Edwin Oei

0147. Experimental Influences on the Anisotropies of Multi-ComponentT2 and Tip in Tendon 651

YangXia, Nian Wang0148. The Shear Modulus of the Nucleus Pulposus Measured Using MR Elastography: A Potential Biomarker for

Intervertebral Disc Degeneration 652

Daniel H. Cortes, Jeremy F. Magland, Alexander C. Wright. Dawn M. Elliott

0149. Feasibility of Using MR Elastography in the Intervertebral Disc and Comparison to Finite Element Model 653

Ephraim 1. Ben-Abraham, Jun Chen, Richard L. Ehman

0150. DCEMRI Shows Slower Wash-Out in Lumbar Disc Endplates to Sustain Diffusion of Nutrients Into the

Discs 654

L. Tugan Muftuler, Hon J. Yu, Vance O. Gardner. Dennis J. Maiman

0151. In-vivo 29Si Magnetic Resonance Imaging of Hyperpolarized Silicon Particles 655

Maja Cassidy. Henry Chan. Pratip Bhattacharya, Charles Marcus

0152. Imaging Caz+ Using Fluorine Chemical Exchange Saturation Transfer ("F-CEST) 656

Amnon Bar-Shir, AssafA. Gilad, Kannie W. Y. Chan, Guanshu Liu, Peter C. M. Van Zijl. Michael T. McMahon, JeffW. M. Bulte

0153. A Novel MR-Visible Persistent Apoptosis Marker Validated with Immunohistochemistry 657

Firas Moosvi, Jennifer H. E. Baker, Andrew Yung, Kenneth Curry, Stefan A. Reinsberg0154. Evaluation ofVanadium-Based Contrast Agents for Detection ofEarly Murine Colon Cancer Using MRI, X-

Ray Fluorescence Microscopy and a Novel Method of Image Co-Registrations 658

Devkumar Mustafi. Jesse Ward, Urszula Dougherty, Erica Markiewicz, Marc Bissonnette, Stefan Vogt, Gregory S. Karczmar

0155. Chemical Doping ofIron Oxide Inside Apoferritin to Form an MRI Contrast Agent with High R, and Low

R2 659

Maria Veronica Clavijo Jordan, Kevin M. Bennett

0156. Using Magnetization Transfer Contrast as a Surrogate Marker for the Occurrence of a Foreign BodyReaction in Hydrogel-Based Cell Therapy 660

Kannie W. Y. Chan, GuanshuLiu, Peter C. M. Van Zijl, Jeff W. M. Bulte, Michael T. McMahon

0157. Macrophage Tracking with Heteronuclear Proton MRI 661

Cornelius Faber, Rebecca Schmidt, Nadine Nippe, Klaus Strobel, Max Masthoff, Carsten Holtke, Olga Reifschneider, DanielaDelli Castelli, Silvio Aime, Christoph Bremer

0158. Imaging Oncolytic Virotherapy Delivery Using a CEST Reporter Gene 662

Christian Thomas Farrar, Jason S. Buhrman, Guanshu Liu, AssafA. Gilad, Michael T. McMahon. Giulia Fulci

0159. Bioengineering a Reporter System That Combines a Highly Sensitive CEST and Fluorescence ImagingProbe 663

Amnon Bar-Shir, Yoshinori Kato, ArvindP. Pathak, JeffW. M. Bulte, AssafA. Gilad

0160. A Bright Multi-Imaging Modality Gene Reporter 664

P. Stephen Patrick, Jayne Hammersley, Louiza Loizou, Mikko 1. Kettunen, Tiago B. Rodrigues, De-En Hu, Sui Seng Tee. Robin

Hesketh, Scott K. Lyons. Silvio Aime, Sandra M. Fulton, Kevin M. Brindle

0161. Dependence ofGradient Echo Phase Contrast on the Differential Signal Decay in Subcellular Compartments 665

Wei Li, Hui Han. Arnaud Guidon, Chunlei Liu

0162. Ultra-High-Field 7T in Vivo Normative Atlas of the Hippocampal Subfields Using Susceptibility Weighted

Imaging 666

Maged Goubran, Brendan Santyr, DaveA. Rudko, Joseph S. Gati, Trevor Szekeres, Terry M. Peters. Alt R. Khan

0163. A 7-Tesla Longitudinal Study on Proportion ofVeins in Plaques of Patients with Multiple Sclerosis 667

Assunta Dai-Bianco, Gunther Grabner, Hans Lassmann, MelanieSchemthaner. Claudia Kronnerwetter, Michael Weber, Clemens

Vass, Karl Kircher, Andreas Reitner, Eduard Auff Siegfried Trattnig

0164. An Improved Susceptibility Weighted Imaging Method Using Multi-Echo Acquisition 668

Sung Suk Oh, Se-Hong Oh. Hyunwook Park, Jongho Lee

0165. Flow Compensated Quantitative Susceptibility Mapping for Venous Oxygenation Imaging 669

Bo Xu, Tian Liu, Pascal Spincemaille, Yi Wang

0166. Magnetic Resonance Venography of the Fetal Brain Using Susceptibility Weighted Imaging (SWI) 670

Jaladhar Neelavali. Haacke Mark Ewart. Swati Mody, Lami Yeo, SheenaSaleem. Yashwanlh Katkuri, Pavan Jella. Ray O. Bahado-

Singh, Sonia Hassan. Robert Romero. Moriah Thomason

0167. Susceptibility Weighted Imaging at 3 Tesla Is Superior to Time-Of-Flight-Angiography for the Detection of

Peripheral Thrombi in Patients with Acute Stroke 671

Alexander Radbruch, Johanna Mucke, Matthias Roethke, Heinz-Peter Schlemmer, Sabine Heiland, Martin Bendszus, Stefan Rohde

0168. Regularized QSM in Seconds 672

Berkin Bilgic, Itthi Chatnuntawech, Audrey Peiwen Fan, Elfar Adalsteinsson

0169. Susceptibility Mapping Using Regularization Enabled Harmonic Artifact Removal 673

Hongfu Sun, Alan H. Wilman

0170. Efficient and Automatic Harmonic Field Pre-Filtering for Brain Quantitative Susceptibility Mapping 674

Ludovic De Rochefort, Hongchen Wang, Paulo Loureiro De Sousa, Jean-PaulArmspach

0171. Accelerated Human Cortical Microstructural Changes from 35 to 40 Weeks ofGestation Characterized with

DTI 675

Qiaowen Yu, Tina Jeon, Shuwei Liu, Hao Huang0172. Evaluation of the Longitudinal Relaxation Rate of Blood in Neonates 676

Jill Brill De Vis, Jeroen Hendrikse, Nikki Dieleman. Floris Groenendaal, Karina J. Kersbergen, Linda S. De Vries. Manon J. N. L.

Benders, Esben Thade Petersen

0173. Quantitative Measurement of Deep Medullary Venous in Susceptibility Weighted Imaging.-Comparison of

Hypoxic-Ischemic and Normal Neonates 677

Ning Ning, Xianjun Li, Jie Gao, Yumiao Zhang, Jianghong Han, XueLuo, Gang Niu, Youmin Guo, EdX. Wu, Jian Yang

0174. Increased Incidence of Intracranial Hemorrhage in Extremely Premature Infants Treated with HypercapnicVentilation 678

XiaweiOu, Charles M. Glasier, Raghu H. Ramakrishnaiah, Sarah B, Mulkey, Vivien L. Yap, Jeffrey R. Kaiser

0175. Quantitative Assessment of Cerebral Metabolism Rate of Oxygen in Neonates 679

Peiying Liu, HaoHuang, Nancy K. Rollins, Tina Jeon, Lina Chalak, Hanzhang Lu

0176. Whole-Brain Connectivity Mapping in Infants Reveals Widespread Areas ofWhite Matter DamageAssociated with Prematurity 680

Anand Pandit, EmmaRobinson, Paul Aljabar, Gareth Ball, loannis S. Gousias, Zi Wang, Giovanni Montana, Jo Hajnal, Daniel

Rueckert, Serena J. Counsell, A. DavidEdwards

0177. Atlas-Based Quantification of Diffusion Tensor Imaging (DTI) and Resting-State Functional MRI (Rs-FMR1) in Children with Cerebral Palsy (CP) 681

Shako Yoshida, Andreia V. Faria, Diane L. Damiano, Chunxiao Zhou, Alexander Hoon, Elaine Stashinko, Kenichi Oishi, James J.

Pekar, Susumu Mori

0178. The Structural Connectome of the Human Brain in Agenesis of the Corpus Callosum 682

Julia P. Owen, Yi-Ou Li, EtayZiv, Zoe Slrominger, Jacquelyn Gold, Polina Bukshpun, Mari Wakahiro, Elliott Sherr, Pratik

Mukherjee

0179. Revealing Morphological Connectome Alternation in Autistic Brain 683

Feng Shi. Li Wang, Ziwen Peng, Chong-Yaw Wee, Dinggang Shen

0180. Altered Structural and Functional Connectivity in Late Preterm Preadolescents 684

Jessica L. Wisnowski, Vincent J. Schmithorst, Rafael C. Ceschin, Patricia Corby. Hanna Damasio, AshokPanigrahyRectal Carcinoma: A "Distance Approach" 685

Stephanie Nougaret

Adnexal Mass Characterization 690Isabelle Thomassin-Naggara

Endometrial Carcinoma: Impact ofMR on Management 691Caroline Reinhold

Cervical Carcinoma: Staging & Follow-Up 693Evis Sola

Liver Lesions: Added Value of Diffusion MRI 694

Bachir Taouli

Renal Lesions: Added Value of Diffusion MRI 700Harriet C. Thoeny

Pelvis: Added Value of Diffusion MRI 702Nandita M. Desouza

Response to Treatment 703Kinh Gian Do

Liver Cell Adenoma: A New Perspective 704Anwar R. Padhani

Non-Contrast MR Angiography ofAbdomen 708

Mitsue Miyazaki

MR Venography 709

Pejman Ghanouni

The Basics 710Alexander P. Lin

Using Edited MRS to Reveal Extra Metabolites 711Richard A. Edden

Techniques for Evaluating Right Ventricle & Pulmonary Arteries 713

MichaelSalerno

Clinical Applications of MRI for Evaluating the Right Ventricle 714Susan Matulevicius

Clinical Applications of MRI in Pulmonary Vascular Disease 717Jens Vogel-Claussen

High Angular Resolution Diffusion Imaging 718Maxime Descoteaux

Susceptibility-Weighted Imaging (SWI) 719Chunlei Liu

Basic Image Manipulation & Measurements 720

Stephen J. WasllingPractical Tips & Tricks to Maximize Repeatability 721

Mark A. Horsfield

Mapping MRI Contrast Enhancement with Histology 722

Kai-Hsiang Chuang

Magnetic Resonance Histology- Cool Images- But Who Cares? 727

G. Allan Johnson. Alexandra Badea, Evan Calabrese, Chuntei Liu, Luke Xie

Diffusion Basics 728

Selh A. Smith

Diffusion Analysis - Absolute Beginner's Guide to Neuroimaging Methods 729

David Raffelt

Technical Aspects - How to Do It 730

Kyung Sung

Advanced MSK MRI Techniques with Clinical Applications 731

William B. Morrison

Fast & Super-Fast Imaging 732

Daniel K. Sodickson

MR in the Emergency Room 733

Pamela Schaefer

Parallel Imaging 736

Michael S. Hansen, Philip J. Beatty

0181. How Clinical Research Trials Changed the Use ofBreast MRI 737

Constance D. Lehman

0182. Innovations in Breast MRI N/A

Donald B. Plewes

0183. Evolution ofBreast Imaging: Beyond Mammomgraphy 741

Christiane K. Kuhl

0184. High Temporal Resolution Retrospective Real-Time Cine Imaging: Shortened Acquisition Via Nonlinear

Reconstruction 743

Hui Xue, Peter Kellman, Andrew E. Arai. MichaelSchacht Hansen

0185. Multi-Node, Multi-GPU Radial GRAPPA Reconstruction for Online, Real-Time, Low-Latency MRI 744

Haris Saybasili. Daniel A. Herzka, Kestutis Barkauskas, Nicole Seiberlich. MarkA. Griswold

0186. Multicenter Evaluation of Dynamic Three-Dimensional Whole-Heart Myocardial Perfusion Imaging at 3.0

Tesla for the Detection of Coronary Artery Disease Defined by Fractional Flow Reserve 745

Robert Manka, Rolf Gebker, Lukas Wissmann, RoyJogiya, Manish Motawani, Michael Frick, Sebastian Reinartz. Bernhard

Schnackenburg, Eike Nagel, Sven Plein, Sebastian Kozerke

0187. Deformable Registration for Improved Constrained Reconstruction of Ungated Cardiac Perfusion MRI 746

Ganesh Adluru, Edward V. R. Dibella

0188. Accelerated Sub-Mm Whole-HeartCoronary MRI: Compressed Sensing Vs. Parallel Imaging 747

Mehmet Akcakaya, Tamer A. Basha, Raymond H. Chan, Warren J. Manning, Reza Nezafat

0189. Autofocusing Nonrigid Respiratory Motion Correction for 3D Cones Coronary MR Angiography 748

R. Reeve Ingle. Holden H. Wu, Nii OkaiAddy, Joseph Y. Cheng, Bob S. Hu, Dwight G. Nishimura

0190. Accelerated 4D Flow CMR Imaging with Variable-Density Random Undersampling and Parallel Imaging 749

JingLiu, Petter Dyverfeldt, MichaelHope, DavidA. Saloner

0191. Quantification of Hepatic Blood Flow in Portal Hypertension Using 4D-Flow MRI: A Meal Challenge Study 750

Alejandro Roldan-Alzate, Alex Frydrychowicz, Oliver Wieben, Scott B. Reeder

0192. The 30-Second Time-Of-Flight Exam: Improving Image Quality with Modern Acceleration Methods 751

Jerome Yerly, RichardFrayne, R. MarcLebel

0193. Ultrafast Non-Contrast Enhanced 4D Dynamic MRA with 3D Stack-Of-Stars Golden Angle Radial

Acquisition and KWIC Reconstruction 752

Robert X. Smith, Lirong Yan, Stanislas Rapacchi, Yiqun Xue, Subashini Srinivasan. Daniel B. Ennis, Peng Hu, HeeKwon Song,

Danny J. J. Wang

0194. Effect of Risk-Reducing Salpingo-Oophorectomy on Breast MRI Fibroglandular Tissue and Background

Parenchymal Enhancement in BRCA1/2 Mutation Carriers: A Quantitative Assessment 753

Shandong Wu, Susan M. Domchek, Michael J. Deleo, Emily F. Conanl, Susan P. Weinstein, Despina Kontos

0195. Parenchymal Enhancement in the Contralateral Normal Breast of Patients Undergoing Neoadjuvant

Chemotherapy Measured by DCE-MRI754

Jeon-Hor Chen, HonJ. Yu, Christine Hsu, MuqingLin, Rita S. Mehta. Min-YingSu

0196. Diffusion Weighted Imaging of the Breast at 7T - Ready for Clinical Application? 755

Olgica Zaric, Katja Pinker, Stephan Gruber, David Porter, Thomas Helbich, Siegfried Trattnig, Wolfgang Bogner

0197. Simultaneous Diffusion MRI and PET Imaging ofBreast Cancer Patients 756

Eric E. Sigmund, Sungheon Kim, Christian Geppert, Linda Moy, David Paul, Christopher B. Glielmi, Kimberly Jackson. Kamil

Bani-Baker, Amy Melsaether

0198. Compartmental Diffusion in Breast Cancer 757

Edna Furman-Haran, Myra Feinberg-Shapiro, Erez Eyal, Dov Grobgeld, Noemi Weisenberg. Noam Nissan, Tania Zehavi,

Hadassa Degani

0199. Reproducibility or Chemical Exchange Saturation Transfer (CEST) MRI ofthe Breast at 7 Tesla 758

Adrienne N. Dula. Lori R. Arlinghaus. Jason M. Williams. Richard G. Abramson. Richard D. Dortch. Seth A. Smith. Thomas E.

Yankeetov

0200. Separation of Benign and Malignant Breast Lesions Using Pharmacokinetic Analysis for a Biopsy Cohort 759

Melanie Freed, AnaPaulaKlautau Leite, Jin Zhang, Melanie Moccaldi. Kai Tobias Block. Linda Moy. Sungheon Kim

0201. Impact of Factors Affecting the Accuracy of Breast MRI in Determining Residual Tumor Size FollowingNeoadjuvant Chemotherapy 760

Jeon-Hor Chen. Shadfar Bahri. RilaS. Mehla. Philip M. Carpenter. Christine E. McLaren, Wen-Pin Chen. David J. B. Hsiang,Min-YingSu

0202. Comparison of a High Spatial Resolution DTI Sequence to Standard DTI for Evaluating Fractional

Anisotropy ofBreast Tumors 761

Lisa J, Wilmes. Cheng-Liang Liu, David C. Newitt, Suchandrima Banerjee, Rebekah L. McLaughlin, Evelyn Proctor, Emine U.

Sari/as, Ajit Shankaranarayanan, Nola M. Hylton0203. Manganese-Enhanced MRI for Early Detection of Breast Cancer Metastatic Potential 762

Joris Tchouala Nofiele, Gregory J. Czarnota, Hat-Ling Margaret Cheng0204. The Robustness ofDSC-PWI for Acute Stroke Imaging; Timing Is Everything: The Vanishing Perfusion

Abnormality 763Irene Klaerke Mikkelsen. Lars Riisgaard Ribe, SusanneLise Bekke, Kim Mouridsen, Leif0stergaard

0205. Multi-Delay Multi-Parametric Arterial Spin-Labeled Perfusion MRI in Acute Ischemic Stroke -

Comparison with Dynamic Susceptibility Contrast Enhanced Perfusion Imaging 764

Danny J. J. Wang, David S. Liebeskind, Joe X. Qiao. Matthias Giinther, Whitney B. Pope, Jeffrey L. Saver, Noriko Salomon. JeffryR. Alger

0206. Derivation of Flow Information from a Hypocarbia Challenge Study Using Time Delay Correlation

Processing 765

Blaise Frederick, Yunjie Tong, Megan Strother, Lisa Nickerson, Kim Lindsey, Manus Donahue

0207. Noninvasive Multi-Echo Vessel-Encoded Arterial Spin Labeling Reactivity for More ComprehensiveQuantification of Hemodynamic Compensation: Development and Clinical Implementation in 50 Patients with

Cerebrovascular Disease 766

Manus J. Donahue, Paul Clemmons, Ricardo Andal, Robert Singer, Diane Brown, Morgan Anderson, Dan Claassen, John

Connors, Lisa Hermann, Lori Jordan, Howard Kirshner, J. Mocco, Ryan Moore, Anne O'Duffy, Derek Riebau. Allen Sills. MeganStrother

0208. Cerebral Perfusion and Vascular Reactivity in Insulin Resistance and Obesity 767

Henry Rusinek, JennyHa, Po Lai Yau, Aziz Tirsi, Wai Hon Tsui, Antonio Convit

0209. Evaluation of a Multiparamteric QBOLD Approach in Acute Stroke Patients 768Julien Bouvier, OlivierDetante, Irene Tropres, Sylvie Grand, David Chechin, Jean-Francois Le Bos, Alexandre Krainik,Emmanuel Luc Barbier

0210. Brain Connectivity and CBF Canges Fllowing Motor Training by MI-BCI Combined with TDCS in Stroke

Patients 769

Xin Hong, Yan Zhi Ong, lrvin Teh, FatimaAHNasrallah, ZhongKang Lu, Wei PengTeo, Cuntai Guan, Kai KengAng, Kok Soon

Phua. Ling Zhao, Effie Chew, Kai-Hsiang Chuang

0211. Dual-Echo Diffusion-Weighted EPI for Better Sensitivity to Acute Stroke 770

Samantha J. Holdsworth. Stefan Skare, Kristen Yeom, Michael U. Antonucci, Jalal B. Andre, Jarrett Rosenberg, Matus Straka,

Nancy J. Fischbein, Greg Zaharchuk, Roland Bammer

0212. Subcortical Volumetric Differences in Children with Sickle Cell Disease and Silent Infarction 771

Jamie M. Kawadler, Jonathan D. Clayden, Fenella J. Kirkham, ChristopherA. Clark

0213. Amide Proton Transfer (APT) Imaging ofAcute Cerebral Infarction: A Preliminary Study on Clinical

Patients 772

Takashi Yoshiura, Akio Hiwatashi, Osamu Togao, Jochen Keupp, Koji Yamashita, Kazufumi Kikuchi, Yuriko Suzuki, Makoto

Obara, Hiroshi Honda

0214. In vivo Spectroscopic Imaging of2-Hydroxyglutarate in Human Gliomas at 7.0 T 773

Sandeep Ganji, Keith M. Hulsey, Elizabeth A. Maher, Changho Choi

0215. Imaging Real-Time Cancer Metabolism with MAD-STEAM HP "C MRSI 774

Christine Leon, Adam B. Kerr. Robert A. Bok, Mark Van Criekinge, Galen D. Reed, Klaus Kruttwig, Andrei Goga, John

Kurhanewicz, John M. Pauly, Daniel B. Vigneron, Peder E. Z. Larson

0216. Partial Volume Corrected CMROj Determination in a Glioblastoma Patient by 170 MRI 775

Stefan H. Hoffmann, AlexanderRadbruch, WolfhardSemmler, Armin M. Nagel

0217. Improved Quantification ofCholine in Breast MRS Using Dixon Imaging Water Referencing 776Lenka Minarikova, Stephan Gruber, Wolfgang Bogner, Katja Pinker-Domenig, Siegfried Trattnig, Thomas Helbich. Marek

Chmelik

0218. Using Paired Tissue and Serum Samples to Characterize Human Lung Cancer Metabolomics with ex vivo

1HHRMAS MRS 777

Hailiang Huang, Emily Decelle, Yannick Berker, Andreas Schuler. Isabel Dittman, Li Su, Eugene J. Mark, Mark J. Daly. David C.

Christiani, Leo L. Cheng0219. In Vivo Evidence for Abnormal Cerebral Bioenergetics in Schizophrenia Measured by 31P MagnetizationTransfer Spectroscopy 778

Fei Du, Alissa Cooper, Thida Thida, Selma Sehovic. Scott Lukas, Bruce Cohen, Xiaoliang Zhang, Dost Ongur0220. Longitudinal Magnetic Resonance Spectroscopy in Premanifest and Early Huntington Disease 779

Bretta Russell-Schulz, Alex L. Mackay, Blair R. Leavitt

0221. Serial Proton MR Spectroscopy ofGray and White Matter in Relapsing-Remitting Multiple Sclerosis 780Ivan I. Kirov, AssafTal, James S. Babb. Joseph Herbert. OdedGonen

0222. Cerebral Glucose Metabolism During Euglycemia and Hypoglycemia in Patients with Type 1 Diabetes 781

Kim C. C. Van De Ven, Marinette Van Der Graaf, Bastiaan E. De Galan. Cees J. Tack, ArendHeerschap

0223. Metabonomics ofGastrointestinal Mucosa in Celiac Disease Using In-Vitro Proton NMR Spectroscopy 782

Naranamangalam R. Jagannathan, Uma R. Sharma, Sujeet R. Mewar, Govind K. Makharia

0224. MR-Guided Focused Ultrasound for the Treatment of Essential Tremor: Initial Experience on MR-Based

Targeting and Temperature Monitoring 783

Yuexi Huang, Nir Lipsman, Michael L. Schwartz. Andres M. Lozano, Kullervo Hynynen

0225. Pain Palliation in Patients with Bone Metastasis Using MR-Guided Focused Ultrasound with Conformal

Bone System: A Preliminary Report 784

Bio Joo, Mi-Suk Park, Soo Hyun Lee, Hye Jin Choi, Young Tag Oh, hay Rachmilevitch, Ori Alar

0226. MRI-Guided Focused Ultrasound-Mediated Drug Delivery to Pancreatic Cancer: Safety and Efficacy 78S

Nalalya Rapoporl, Allison H. Payne, Christopher Dillon, Jill E. Shea

0227. Apparent Diffusion Coefficient Decrease During Thermal Ablation ofthe Prostate as an Early Indicator for

Loss ofTissue Viability 786

Juan C. Plata, Andrew B. Holbrook. Michael Marx, VasantSalgaonkar, Peter Jones, Chris J, Diederich, Aurea Pascal-Tenorio.

Donna Bouley. Graham Sommer, Kim R. Butts Pauly

0228. Selective Brain Cooling in Sheep by Intra-Ventricular Catheters: A 7T BIRDS Study 787

Daniel Coman, Yuegao Huang, John W. Simmons, James A. Goodrich, Brain McHugh, John A. Elefteriades, Douglas L. Rothman,Fahmeed Hyder

0229. Comprehensive Comparison ofSix Referenceless PRF Shift MR Thermometry Methods 788

Changjun Tie, Chao Zou, MengyueHe, Wensha Guo, Yiu-Cho Chung, Xin Liu

0230. In Vivo Validation ofT2-Based MR Thermometry in Adipose Tissue Layers for HIFU Near-Field

Monitoring 789

Paul Baron, Mario Ries. Martijn De Greef, Roel Deckers, MaxKohler, Jukka Tanttu, Chrit T. W. Moonen. Lambertus W. Bartels

0231. Non-Invasive In Vivo Loss Tangent Imaging: Thermal Sensitivity Estimation at the Larmor Frequency 790

Narae Choi, Joonsung Lee, Min-Oh Kim, JaewookShin, Dong-Hyun Kim

0232. Towards Improving Predictive Capabilities of MR-ARFI for Transcranial Focused Ultrasound Therapy 791

Elena Kaye, Yoni Herzberg, Gil Navon, Kim R. Butts Pauly

0233. Hybrid US-MR Guided HIFU Treatment Method with 3D Motion Compensation 792

Zarko Celicanin, Vincent Auboiraux, Oliver Bieri, Lorena Petrusca, Yutaka Natsuaki, Francesco Santini, Magalie Viallon, Klaus

Scheffler, Rares Salomir

0234. Casein Coated Magnetic Iron Oxide Nanoparticles forTargeted Imaging and Drug Delivery 793

Jing Huang, Hyunseok Kang, Liya Wang, Run Lin, Xianghong Peng, Lily Yang, DongMoon Shin, Hui Mao

0235. Sustained Restoration ofLV Dysfunction in a Pig Ischemia-Reperfusion Injury Model Using Human

Amnion-Derived Mesenchymal Stem Cells Tracked by Manganese-Enhanced MR1 794

Rajesh Dash, Paul Kim, Yuka Matsuura, Fumiaki Ikeno, Jennifer Lyons, Xiaohu Ge, Scott Metzler, Ngan Huang, Patricia Nguyen,Joseph Wu, John Cooke, Pilar Ruiz-Lozano, Robert C. Robbins. Michael V. McConnell, Alan C. Yeung, Phillip Harnish, Phillip C.

Yang

0236. MR Imaging ofCancer Vasculature Using VEGF Receptor-Targeted Dual Contrast Labeled Liposomes 795

Yoshinori Kato, Wenlian Zhu, Marina V. Backer, Ronnie C. Mease, SusantaK. Sarkar, Joseph M. Backer, Dmitri Artemov

0237. E-Selectin Targeted USPIO Enhancement of Atherosclerotic Plaques Visualizes Treatment Response and

Mechanism ofAction 796

Brigit Den Adel, Ernst Suidgeest, Carmen Burtea, Marieke Stammes, Kim Van Der Heiden, Sophie Laurent, Robert E. Poelmann,

RobertN. Muller, Louise Van Der Weerd

0238. Two Component System for MR/optical Image-Guided Delivery and Cell Surface Targeting of HER2(+)Cancer Cells 797

Sudalh Hapuarachchige, Wenlian Zhu, Yoshinori Kato, Dmitri Artemov

0239. A PSMA-Targeted Theranostic Nanoplex Combining TRAIL Gene CDNA and Prodrug Enzyme Deliveryfor Prostate Cancer Treatment 798

Zhihang Chen, Marie-France Penet, Balaji Krishnamachary, Sangeeta Ray, Cong Li, Paul T. Winnard, Martin G. Pomper, Zaver

M. Bhujwalla

0240. EGFR MAb-Bioconjugated Superparamagnetic Iron Oxide Nanoparticles as a Specific MRI Contrast Agentfor Detection of Brain Glioma In Vivo 799

Tao Mu, Yuanyuan Qin, Yan Zhang, He Wang, Wenzhen Zhu

0241. Integrated PET/MRI with MGa-DOTATOC in Patients with Neuroendocrine Tumors - First Results 800

Karsten Beiderwellen, Thorsten D. Poeppel, Verena Hartung-Knemeyer, Christian Buchbender, HilmarKuehl, Andreas Bockisch,

Thomas C. Lauenstein

0242. Molecular Imaging of Cancer with Paramagnetic Vesicles Targeted to Phosphatidylserine 801

Patrick Winter, John Pearce, Zhengtao Chu, Jing-Huei Lee, Xiaoyang Qi

0243. In Vivo Quantification of Inflammation Burden in an Experimental Allergic Encephalomyelitis Rat Model

Using Fluorine-19 MRI 802

Jia Zhong, Penelope Morel, Hongyan Xu, Lisa Pusateri, Eric T. Ahrens

0244. Tl-Weighted Imaging of Lumbar Spine Using Multiband Slice Accelerated Spin Echo 803

Dingxin Wang, Peter D. Kollasch, EdwardJ. Auerbach, Steen Moeller, Bhat Himanshu, Kamil Ugurbil, Vibhas Deshpande

0245. Fast T2 Weighted Imaging with PSIF in the Abdomen at 3T 804

Chao Zou, Wensha Guo. Xin Liu, Yiu-Cho Chung

0246. A Variable Bandwidth Radial Gradient and Spin-Echo (VB-RadGRASE) Method for Improved T2 and Fat-

Water Parameter Estimation 805

Mahesh Bharath Keerthivasan, Jean-Philippe Galons, Puneet Sharma, Diego R. Martin, Ali Bilgin. Maria 1. Altbach

0247. Multi-Echo Acquisition of 3D TOF and SWI of Radiation-Induced Cerebral Microbleeds at 7T 806

Wei Bian, Suchandrima Banerjee, Douglas A. C. Kelly, Susan M. Chang, Sarah J. Nelson. Janine M. Lupo

0248. Optimization ofCube-FLAIR 3D FSE Imaging at 7T 807

Manojkumar Saranathan, Thomas Tourdias, Michael Zeineh, Adam Kerr, Jeffrey D. Bernstein, Geoff A. Kerchner, Brian K. Run

0249. SAR and Scan-Time Optimized 3D Whole-Brain Double Inversion Recovery (DIR) Imaging 808

Eberhard Daniel Pracht, Thorsten Feiweier, Philipp Ehses, Daniel Brenner, Bemd Weber, TonyStocker

0250. Rapid Tracking of Soft Palate Motion During Speech Using Pencil Beam and Turbo Navigators 809

AndrewDavid Scott. Redha Boubertakh, Malcolm Birch, Marie Pinkstone, Marc Eric Miguel

0251. Real-Time MRI Can Differentiate Sleep-Related Breathing Disorders in Children 810

Yoon-Chul Kim. Shirleen Loloyan. Ziyue Wu, Winston Tran, Roberta Kato, Sally L. D. Ward, Michael C. K. Khoo, Krishna S.

Nayak

0252. Fat Saturation for 2D Small-Tip Fast Recovery Imaging UsingTailored 3D Spectral-Spatial Pulses 811

Feng Zhao, Jon-Fredrik Nielsen, Douglas C. Noll

0253. Reduction of Acoustic Noise to Improve Patient ComfortThrough Optimized Sequence Design 812

Eric Yann Pierre, DavidManuel Grodzki, Bjoem Heismann, Vikas Gulani, JeffreySunshine, KechengLiu, Mark A. Griswold

Inflammatory Bowel Disease: Technique 813Sharon E. Clarke

Inflammatory Bowel Disease: Case Studies 815

Stuart A. Taylor

MRI ofPerianal Fistulas 816

Roy S, Dwarkasing

Retrospective Motion Correction for Cardiovascular and Body Imaging 818

Freddy Odille

Clinical & Research Applications ofBone Imaging 825

Thomas M. Link

Free Induction Decay Imaging of Short-Lived Signals 826

Michael Garwood

MRI Assessment ofTrabecular & Cortical Bone Structure & Strength 827

Felix W. Wehrli

Magnetic Resonance Imaging Bone Marrow 830

Xiaojuan Li

Imaging Bone Water Compartments 832

Jiang Du

Clinical Applications of Diffusion Imaging in the Spine 843

Lawrence Neil Tanenbaum

0254. Acute Hemorrhagic Myocardial Infarction Leads to Localized Chronic Iron Deposition: A CMR Study 864

Avinash Kali, Ivan Cokic, Andreas Kumar, RichardL Q Tang, Sotirios A. Tsaftaris, Matthias G. Friedrich, Rohan Dharmakumar

0255. Quantitative T2 Mapping Visualizes Hemorrhage and Edema After Acute Myocardial Infarction in Swine 865

Haiyan Ding, Michael Schar, Elliot R. McVeigh, Henry Halperin, M. Muz Zviman, Roy Beinart, DanielA. Herzka

0256. Tl Mapping After Acute Myocardial Infarction: Multiphase Phase-Sensitive Inversion-Recovery (MpPSIR)Method as Valuable Alternative to the Modified Look-Locker Inversion Recovery (MOLLI) Method 866

Oliver M. Weber, Javier Sanchez-Gonzalez, LeticiaFernandez-Friera, Gonzalo Pizarro-Sanchez, Jesus G. Mirelis, RodrigoFernandez-Jimenez, Luis Jesus Jimenez-Borreguero, Christian Stehning, Valentin Fuster, Borja Ibanez

0257. Combined Saturation/Inversion Recovery Sequences for Improved Evaluation of Scar and Diffuse Fibrosis

in Patients with Arrhythmia or Heart Rate Variability 867

Sebastian Weingartner, Mehmet Akqakaya, Kraig V. Kissinger, Beth Goddu. Sophie J. Berg, Warren J. Manning, Reza Nezafat

0258. Three-Dimensional MOLLI for Myocardial Tl Mapping Using Respiratory Navigation and Inversion Time

Gating 868

Tobias Voigt, Tobias Schaeffter, Rene M. Botnar, JoukeSmink, Markus Henningsson0259. Assessment of Myocardial Radiofrequency Ablation Lesions with 3D High Resolution Free-Breathing T2

Mapping 869Daniel A. Herzka, Haiyan Ding. Farhad Pashakhanloo, Karl H. Schuleri, Aravindan Kolandaivelu, Elliot R. McVeigh, Henry

Halperin, M. Muz Zviman, Roy Beinart

0260. The Dual-IR Sequence Improves the Inter-Observer Correlation in Post-Ablation Atrial Scar Size

Measurements Compared to the Traditional IR Sequence 870

Sarah Anne Peel, Aruna Arujuna, James Harrison, Zhong Chen, Kawal Rhode, Jaswmder Gill, Reza Razavi. Tobias Schaeffter,Rene M. Botnar

0261. Is Fat-Suppression Necessary to Evaluate Remodeling in the Left Atrium with Late Gadolinium

Enhancement? 871

Dana C. Peters, Jaime L. Shaw, James William Goldfarb, Warren J. Manning

0262. A New Method for Accurate Myocardial Tl Mapping Using Variable Angle Long Echo Train Relaxometric

Imaging (VALERI) 872Thanh D. Nguyen, Mitchell A. Cooper, Pascal Spincemaille. Jonathan W. Weinsaft, Martin R. Prince, Yi Wang

0263. Myocardial ATP Turnover Rates in the in vivo Hearts with Post-Infarction Remodeling 873

QiangXiong, Pengyuan Zhang. Lei Ye, Jinfeng Tian, Cory Swingen, Albert Jang, J. Thomas Vanghan, Jianyi Zhang0264. A Multi-Resolution Anatomical Atlas ofthe Human Brainstem Based on Diffusion Tensor Imaging at 11.7T 874

Manisha Aggarwal, Jiangyang Zhang, Olga Pletnikova, Barbara Crain, Juan Troncoso, Susumu Mori

0265. Comparison with Histology of Quantitative MR Properties of the Brain Stem Tissue in 3T and 7T 875Anna I. Blazejewska, SamuelJ. Wharton. Stefan T. Schwarz, James Lowe, Dorothee P. Auer, Richard W. Bowtell, Penelope A.Gowland

0266. Exploring Cortical Cytoarchitecture in High Resolution Rl Maps 876

Jose P. Marques. Rolf Gruetter

0267. High-Resolution Quantitative Tl Maps of the Human Stria of Gennari at 7 Tesla 877Christine Lucas Tardif, Miriam Waehnert. Juliane Dinse, AndreasSchafer, Pierre-Louis Bazin, Robert Turner

0268. Motion-Corrected 350 um Isotropic MPRAGE at 3 T Using Volumetric Navigators (VNavs) 878Matthew Dylan Tisdall, Jonathan R. Polimeni, Andre J. W. Van Der Kouwe

0269. A Simple Method to Denoise MP2RAGE 879Kieran O'Brien. Gimnar Krueger. Francois Lazeyras, RolfGruelter, Alexis Roche

0270. How Much Resolution Is Needed for in-vivo Analysis of Cortical Myeloarchitecture? 880Miriam Waehnerl, Juliane Dime, Christine Lucas Tardif. Andreas Schafer. Stefan Geyer. Pierre-Louis Bazin. Robert Turner

0271. The Fixation Protocol Alters Brain Morphology in ex-vivo MRI Mouse Phenotyping 881

A. Elizabeth De Guzman, Michael D. Wong, Jacqueline A. Gleave, Brian J. Nieman

0272. MRI of Cell Layers in Mouse Brain in Vivo Using Intra- And Extra-Cellular Contrast Agents 882

Takashi Watanabe, Jens Frahm, Thomas Michaelis

0273. Magic Angle Enhanced MR Microscopy of Fibrous Structures in the Eye 883

Kevin C. Chan, Zion Tse, Ning-Jiun Jan, Joel S. Schuman, Seong-Gi Kim. tan A. Sigal

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