APPLE TESLA STIRLING · Stirling Engine Location Stirling • Compact technical compartment – More space for samples • Compartment is located on top – Heat removed by HVAC is

A complete new approach in

the world of Cold Storage

APPLE

TESLA

STIRLING

ULT Technologies Overview

Compressor

Stirling

10/30/2018 2

Stirling engine: Internal View

ULT compressor systems

• One or two compressors in a (auto)

cascade arrangement

• Temperature Control: switching

compressor(s) on and off

• Circulates (pumping) HFC refrigerant & oil

through complete cooling system

(copper lines, capillary tube, oil separator, fluid

separator, compressor(s) condenser

• High pressures and pressure differences

• 12 up to 24 moving parts

• High energy consumption and high heat

output

• Sensitive for room temperature, warm

material loading and clogging filter

• High maintenance and not easy to repair

• Noisy and Vibration

• Voltage, Amps and Hz is very sensitive for

compressors

10/30/2018 4

CABINET HEAT LEAK

COMPRESSORS

ULT Stirling and thermosiphon system

• Free piston Stirling engine (completely sealed)

– 2 moving parts

– No oils or lubricants required

– No hard to hard contact

– No life limiting sales and bearings

– Gas bearing (10 gram He)

– Continuous modulation: fully adaptive control

– Energy efficient

– Quiet and low vibration

– Long life

– Not sensitive for room temperature,

– Not sensitive for warm material loading

– No filter

Vap

or

Energy is

Transferred as

Vapor Condenses

at Cold Head

Liq

uid

Co

nd

en

sate

• Thermosiphon:

– Sealed tube uses gravity with continuous condensation and

evaporation

– No suction or discharge system (not pumping)

– No high pressure and pressure differences

– Tube is isothermal – same temperature beginning to end;

creates better interior surface uniformity

– Uses only 90 grams ethane (R-170)

Life Science Refrigeration Landscape

10/30/2018 6

-20˚C to -86ºC Product Line

SU780XLE

780 liter

60.000 to 70.000 vials

SU105U

105 liter

(shown stacked)

7.200 vials

Shuttle™

25 liter

1.800 vials

10/30/2018 7

Stirling Engine Location

Stirling

• Compact technical compartment

– More space for samples

• Compartment is located on top

– Heat removed by HVAC is not heating

up the total room

– Electronics are safely away from dust

and water

– No backspace needed. You can put the

Stirling Freezer directly to the wall

• Simple system

– No filter needed

– Easy access, repair and maintenance

Stirling Engine: Proven Technology

Stirling Field-Proven Technology

Over 3000 Stirling Ultracold Small Products in

the Field . . .

• Clinical Trials

• Drug Delivery

• Wound Care/Tissue Storage

• BioPharma/BioTech

• Government & Hospital

Research

Stirling Field-Proven Technology

Trusted by over 100’s of research facilities and

institutions including . . .

Academic Research

Albert Einstein College of Medicine

Duke University

University of California (Davis & San

Francisco)

Case Western Reserve University

Biorepositories

National Cancer Institute

Fred Hutchinson Cancer Center

Masy Systems

BioPharma

Roche Diagnostics

Pfizer

GlaxoSmithKline

Boehringer Ingelheim Pharmaceuticals

AbbVie Bioresearch Center

Eli Lilly & Co.

Government/Non-Profit Research

NIH/National Cancer Institute

USDA

Fred Hutchinson Cancer Research Center

Howard Hughes Medical Institute

USAMRIID (US Army)

BioTech

Genentech

Amgen

Novartis

Seattle Genetics

Hospital Research

Seattle Children’s Research Institute

Mayo Clinic

Cleveland Clinic

10/30/2018 11

10/30/2018 12

Broad Range of Customers

Industry’s Best Cooling Performance

• Best temperature stability

• 100% adaptive control

• Largest temperature set point range: -20° to -86°C

• Slowest warm-up time after power loss

• Fastest pull down and temperature recovery

10/30/2018 13

10/30/2018 14

FIRST ENERGY STAR® Certified ULTs

Since July 2017 SU780XLE upright model is the

industry’s FIRST ENERGY STAR certified ULT

freezer, setting the standard and validating the

industry’s top energy-efficiency rating

Stirling Ultracold SU780XLE EPA Final Test Method Results

(independently tested)

• 7.86 kWh: -75˚C (24-hour test period)

• 6.86 kWh: -75˚C (steady state period)

10/30/2018 15

EPA ENERGY STAR® Test Results

What are compressor-based ULTs really costing

your organization?

Based on installed base energy use data at 16c/kWh electric costs, with typical

floor space and compressor replacement cost estimates from independent sources.

PERCENT OF TOTAL COST(per cu. ft. per yr.)

10/30/2018 16

Think Strategically About ULT Costs

Initial Purchase

Price

28%

Compressor

Replacement Cost

11% HVAC Cost Impact

11%

Energy

Consumption Cost

39%

Floor Space Cost

11%

Simple and Easily Accessible

Stirling cooling

engine

LN2/CO2 backup

connection

Battery backup -

controls

Touch

screen

Cold head

insulation

Thermosiphon

insulation

Power input,

dry contacts

Power and

control

electronics

Fan

Fan

10/30/2018 17

Summary Technical Specifications• 780 liter capacity (60.000 or even 70.000 vials)

• Largest Storage Capacity in vial / m2

• Advanced noise abatement, <45 dB(A) at 1 meter

• Graphic User Interface with touch screen

• Ambient Operating Temperature +5ºC to +35ºC

• 100V – 240 V (+/- 10%) at either 50 Hz or 60 Hz

• Helium charged free-piston Stirling engine cooling

• Stable temperature setting range of -20˚C to -86˚C

• Gravity driven thermosiphon gives best cooling performance

• - pull down to -86˚C in less than 6,5 hours

- door open recovery in 35 minutes back to -80˚C

- warm-up 2,5 hours from -80˚C to -60˚C

- uniformity 7,5˚C or better

• - stability 1,5˚C or better

• Low Energy 6,86 kWh/day

• 2 stainless steel reinforced shelves comes standard

• - adjustable every 1,27 cm, hold 70 kg load per shelve

Stirling Ultracold delivers significant benefits to all

10/30/2018 19

What We Deliver

Small and Portable Ultra-Low

Temperature Products

Stirling Ultracold Advantages

• Undercounter/stackable or portable models

• Wide temperature range, -86°C to -20°C

• No compressors to fail!

• Lightweight shuttle – only 18 kg

• Smallest footprint in its class

• Plugs into any outlet worldwide 120V-240V

50/60hz

• Lockable personal storage

• 100% natural refrigerants

• Operates on 12V DC power supply (Shuttle)

The world’s only portable

Ultra-Low Temperature freezer

• Remote Clinical Trials

• Biologic Drug Delivery

• Skin graft preservation & delivery

• Mobile, on site forensic DNA

preservation

Shuttle™ Model ULT-25NE

Portable ULT Storage Solutions

Easily Transported

Portable

-86 °C to -20 °C

Specimen Storage

Annexes

Top Cover

• Two piece top for easy removal

Cabinet

• The cabinet utilizes vacuum-insulated panels with

polyurethane foam

• Thermosiphon cooled inner wall

• Magnetic latching inner doors

• A single handed use door handle that ensures door gasket

compression when closed

• Three flexible door gaskets

• Gasket defrost minimizes water or ice deposition on the

gasket interface

• Vacuum Breaker utilizing passive heating

Inner Doors

• Insulated

• Magnetic Latching

Gaskets

• Three flexible door gaskets

Door Handle

• One handed

operation

• Integrated pad lock

loops

• Kick Back release

function

Shelves

• Adjustable

• 70 kg each

10/30/201830

Access Port and LN2 back-up port

Touch Screen Menu10/30/201832

• Temperature control

• Alarm system

• Gasket defrost

• Event log / Chart history

• Service screen

• Calibration screen

• Maintenance

• Battery

Temperature Control

• Fully adjustable between -20 to -86 °C

• Alarms adjustable from 1 to 20 °C

Alarm system

• External (dry contact) / Audible / Visual

• Optional 4-20 MA output available

Door Gasket Defrost

• Adjustable 0 – 100%

10/30/201835

Event log

• Displays events such as door openings and alarms.

– 200 events stored in 30 pages

Chart history

• Displays internal box temperature

– Last 12 hrs, 24 hrs or 7 days. Tap screen to enlarge.

Service Screen

• Used for Troubleshooting

– Password 4570

10/30/201838

Maintenance

• About Screen

RTD Calibration

• Calibration Screen

Battery Reminder-

• Replace Battery Every 2 Years

External Connections

External Connections

Remote Alarms

• Dry Contacts-

– Normally Open

– Normally Closed

– Common

Utilized for building management systems and remote monitoring

alarms.

4- 20 Milliamp Option

10/30/

2018

45

• 4-20 Milliamp Output

– Optional accessory ordered with unit

– Is a non-powered connection

• 4 Ma = -100C

• 20 Ma = 0C

Low Maintenance and Service requirements

Monthly maintenance

• De-ice Gaskets with scraper

• Inspect Vacuum Relief port

Yearly maintenance

• Check and clean heat reject fins

(compressed air and vacuum)

• Check door alignment

Every 2nd year maintenance

• Replace Battery

Advantages Across the Organization

Energy

Manager

Service

Facility

Manager

Researcher

Lab

Manager

Strategic

Purchasing /

Finance

Sustainability

Director

Natural

Refrigerants

Temperature

Flexibility

Highest

ReliabilityLongest Life

Low

Maintenance

Reduced

Infrastructure

Lowest Heat

Rejection

Lowest

Energy Use

Architect

Best

Performance

Research

Organization

Voltage

Flexibility

Lowest Cost of

Ownership

10/30/2018 47

10/30/2018 48

Service

Facility

Manager

Researcher

Lab

Manager

Strategic

Purchasing /

Finance

Natural

Refrigerants

Temperature

Flexibility

Highest


Low

Maintenance

Reduced

Infrastructure

Lowest Heat

Rejection

Lowest

Energy Use

Architect

Best

Performance

Research

Organization

Voltage

Flexibility

Lowest Cost of

Ownership


10/30/2018 49


Since July 2017 SU780XLE upright model is the

industry’s FIRST ENERGY STAR certified ULT

freezer, setting the standard and validating the

industry’s top energy-efficiency rating

10/30/2018 50


Above screen captured from energystar.gov website on 8/14/17

Stirling Ultracold SU780XLE EPA Final Test Method Results

(independently tested)

• 7.86 kWh: -75˚C (24-hour test period)

• 6.86 kWh: -75˚C (steady state period)

10/30/2018 51

EPA ENERGY STAR® Test Results

Energy Consumption: ULT Freezers

http://etcc-ca.com/reports/ultra-low-temperature-freezers-opening-door-energy-savings-laboratories

SU780UE

SU780XLE

10/30/2018 52

EPA Approved, 100% Natural

• SU780UE was first ULT freezer

approved for hydrocarbon

refrigerants in the U.S.

– 10 grams of helium

– 90 grams of ethane

• Ecomate Foam Insulation

Blowing Agent

– Zero GWP

– Zero ODP

– U.S. EPA approved

• Zero Waste Facility

– Gold certification

10/30/2018 53

10/30/2018 54


Energy

Manager

Service

Facility

Manager

Strategic

Purchasing /

Finance

Sustainability

Director

Natural

Refrigerants

Temperature

Flexibility

Highest


Low

Maintenance

Reduced

Infrastructure

Lowest Heat

Rejection

Lowest

Energy Use

Architect

Best

Performance

Research

Organization

Voltage

Flexibility

Lowest Cost of

Ownership

Moving parts wear out Don’t wear out – gas bearings

Up to 24 moving parts to fail Only 2 moving parts

Oil lubrication management No oil

Compressor valves No valves

Stop-start operation Continuous operation with 100%

adaptive control

On-off operation – surge currents No surge currents

Why Compressors Fail Stirling Solution

10/30/2018 55

A Reliable Answer to Compressor Failure

Industry’s Best Cooling Performance

• Best temperature stability

• 100% adaptive control

• Largest temperature set point range: -20° to -86°C

• Slowest warm-up time after power loss

• Fastest pull down and temperature recovery

10/30/2018 56

Best Uniformity

(across space)Best Stability

(over time)

Time (HOURS)

Steady-State Period

10/30/2018 57

Best Temperature Uniformity & Stability

Time (HOURS)

Best Pull Down & Door Recovery

Best

Pull Down

Best Door

Recovery

Time (HOURS)

6 door

openings

@ 1 hour

intervals

10/30/2018 58

10/30/2018 59


Energy

Manager

Service

Facility

Manager

Researcher

Lab

Manager

Sustainability

Director

Natural

Refrigerants

Temperature

Flexibility

Highest


Low

Maintenance

Reduced

Infrastructure

Lowest Heat

Rejection

Lowest

Energy Use

Architect

Best

Performance

Research

Organization

Voltage

Flexibility

Lowest Cost of

Ownership

What are compressor-based ULTs really costing

your organization?

Based on installed base energy use data at 16c/kWh electric costs, with typical

floor space and compressor replacement cost estimates from independent sources.

PERCENT OF TOTAL COST(per cu. ft. per yr.)

10/30/2018 60

Think Strategically About ULT Costs

Initial Purchase

Price

28%

Compressor

Replacement Cost

11% HVAC Cost Impact

11%

Energy

Consumption Cost

39%

Floor Space Cost

11%

10/30/2018 61


Energy

Manager

Service

Researcher

Lab

Manager

Strategic

Purchasing /

Finance

Sustainability

Director

Natural

Refrigerants

Temperature

Flexibility

Highest


Low

Maintenance

Reduced

Infrastructure

Lowest Heat

Rejection

Lowest

Energy Use

Best

Performance

Research

Organization

Voltage

Flexibility

Lowest Cost of

Ownership

Lower power use and no surge currents• Less electrical infrastructure

• Less AC load

• Less backup power and fuel

• Brown-out tolerant

Universal voltage input• 110-240V auto switching

• 50 or 60 Hz auto switching

• Siting flexibility

10/30/2018 62

Reductions in Research Facility Infrastructure

10/30/2018 63


Energy

Manager

Facility

Manager

Researcher

Lab

Manager

Strategic

Purchasing /

Finance

Sustainability

Director

Natural

Refrigerants

Temperature

Flexibility

Highest


Low

Maintenance

Reduced

Infrastructure

Lowest Heat

Rejection

Lowest

Energy Use

Architect

Best

Performance

Research

Organization

Voltage

Flexibility

Lowest Cost of

Ownership

Simple and Easily Accessible

Stirling cooling

engine

LN2/CO2 backup

connection

Battery backup -

controls

Touch

screen

Cold head

insulation

Thermosiphon

insulation

Power input,

dry contacts

Power and

control

electronics

Fan

Fan

10/30/2018 64

10/30/2018 65


Energy

Manager

Service

Facility

Manager

Researcher

Lab

Manager

Strategic

Purchasing /

Finance

Sustainability

Director

Natural

Refrigerants

Temperature

Flexibility

Highest


Low

Maintenance

Reduced

Infrastructure

Lowest Heat

Rejection

Lowest

Energy Use

Architect

Best

Performance

Research

Organization

Voltage

Flexibility

Lowest Cost of

Ownership

Small Ultra-Low

Temperature Solutions for

Clinical Trials, Biologic Drug

Delivery and Cold Storage

Contents

• ULT25NE Specifications

• Controller

• Pull down & Warm up graph

• Dimensions

• Options & Accessories

• Service / Warranty

• Customers and Target Markets

• Questions

ULT25NE specifications

• 25 liters volume, personal freezer

• Temperature range -20ºC to -86ºC

• 100 % natural refrigerant (R170)

• Operates on any power source (120V-240V and 12V DC)

(will work with any power grid worldwide!)

• Portable or Stationary use (21 kg empty)

• Standard access port for external monitoring

• Audible Alarm (+/- 10ºC over / under setpoint)

• Lowest power consumption (2,8 kWh/day)

• Low noise level

• Low heat output, air movement

(ideal in a clean lab environment)

ULT25NE specifications

(continued)

1. Outer lid with double gasket moisture seal and inner lid made of high-density, closed cell rigid foam

2. Easy control panel

3. Lid latch for positive closure

4. 6,3 mm access port for external temperature probe

5. Easy to clean slide-out filter

6. AC power connection (polarized to avoid errors)

7. DC power connection

8. Optional temperature probe clip

9. Optional remote alarm

10.Locking lid for sample integrity

ULT25NE controller

A. Seven-segment display with chamber temperature

B. On / Off button

C. Check and temperature setting

D. Scroll buttons

Others: - postpone alarms

- lock and unlock panel

- check error codes

- temperature preset buttons

(-86ºC, -40ºC and -20º)

• AC power cable 120V - 240V 50/60 Hz

• DC power cable 12 V

• Factory Options – Calibration Certificate, Factory installed Dry Contacts, Temperature Mapping Validation

• Replacement parts – keys, packaging, gasket kits, port plugs / sealant

• 1 year parts & labor warranty (warranty covers

shipping to and from our nearest repair facility)

*Shipping & handling to our repair facility are included during parts & labor

period only.

• Biorepositories

• Pathology labs

• Tissue banks

• Regenerative, clinical and diagnostic medicine

(stem cells)

• Transport of biological specimens

• ULT pharma distribution

• Hospitals

• All energy efficient storage for cold-chain management

Companies that use Regenerative Medicines for Orthopaedics & Wound Care

Developers / Distributors purchase freezers for treatment centres that offer their brand of medicine –provided with the medicine for storage

Resulting in large quantity purchases (20 – 60) depending on tiered pricing

Key words:

allografts, autografts, xenografts

Decision makers are typically Operations Managers

Biotech Pharmaceutical Companies

These companies purchase Shuttle freezers to be used during clinical trials. (typically provided to pharmacies to store medicine for trial)

These opportunities are large quantity sales (typically 100 – 200 units)

Once the medicine is approved for the market it is typical for the Pharmaceutical Company to recommend the Freezer to store their medicines.

(easy to ship, small footprint, power adaptability, bench top chest)

SU105UE Compact Ultra-Low Freezer

• Undercounter

• Benchtop

• Stackable

• Personalized Ultra-Low Storage

Thank You!

10/30/2018

Documents

APPLE TESLA STIRLING · Stirling Engine Location Stirling • Compact technical compartment – More space for samples • Compartment is located on top – Heat removed by HVAC is