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Apivar®
• Effective tool specially designed for Varroa Mite
management in honeybee colonies
• Controlled-release strips formulated with 3.3%
Amitraz (0.5g active per 15g strip)
Apivar®: a new tool to rely on
➜Continuously released amitraz in the colony over a six-week treatment, ensuring healthy and productive colonies
➜ Kills up to 99% of mites in one application
➜ Proven safe and effective for more than 15 years
➜ Leaves no significant residues in hive products
➜Convenient and easy to use
Amitraz :
Miticide well-known for its effectiveness
DROP FROM
BEE BACK
AMITRAZ
Contact
MOVEMENT DIFFICULTIES
PARALYSIS
DEATH DUE TO
STARVATION
No immediate knock-down. Gradual reduction of mites over extended period
Continuously-released
in the colony over a six-week period
Contact action only = no vaporization into the atmosphere of the hives. High importance of positioning into the colony for a high level of efficacyContact action only = no vaporization into the atmosphere of the hives. High importance of positioning into the colony for a high level of efficacy
Apivar interrupts the mite reproduction cycle
A fertilized female Varroa
mite enters the cell.
The cell is sealed and the fertilized
Varroa mite enclosed feeds on
haemolymph from the bee larva.
The female mite lays an egg every
30 hours. The first offspring is a male;
the subsequent offspring are all female.
The female mite continues to lay eggs.
When the female offspring reach sexual
maturity, they are fertilized
by the one male mite in the cell.
The young bee leaves the cell
carrying two fertilized female
mites.
Apivar kills the phoretic mites,
as well as successive generations,
leaving the bees mite-free.
Theoretical modeling of the effects of 2 types of treatments
Repeated short-acting treatment or single-shot controlled-released treatment
Advantage of long release technology
Kills up to 99% of mites
in one application
Effective
to control Varroa mite infestation
High level of effectiveness of amitraz
+ High quality standard of amitraz
+ Long release technology
More than 15 years of effectiveness of Apivar®
Many effectiveness studies performed in numerous countries
under different environmental conditions
(France, New-Zealand, Canada, USA, Japan, Turkey…)
Field effectiveness study
USA - 2009
”Compared to control colonies,
Apivar® reduced mite loads significantly (P < 0,0001)”
Jeff Pettis, Denis vanEngelsdorp 2009
Field effectiveness trialUSA – Spring 2012
“Controlling Varroa destructor with APIVAR”
Eischen et al, Honey bee research Unit, USDA-ARS, Weslaco, TX
APIVAR® = 52-fold drop in mite population against untreated control
Threshold for efficacy = 10-fold difference between the negative control mite level and experimental treatment
Effectiveness studyCanada – Fall 2008
”EFFICACY OF APIVAR ON THE VARROA MITE, VARROA DESTRUCTOR,
IN ALBERTA ,CANADA ”
Fall 2008, Nasr et al
Source : Nasr et al, Efficacy of Apivar on the Varroa Mite, Varroa destructor in Alberta, Canada. 2012 Canadian Pest Surveillance
Branch, Research and Innovation Division, Agriculture and Rural Development.
2012 US Field trial
• Apivar effectiveness (20 hives treated with Apivar in 3 apiaries, Autumn 2012)
22,15
4,60
Mean
Varroa infestation rate
after 6 weeks of Apivar® treatment (# Varroa / 300 bees)
Before treatment After treatment
2012 US Field trial
• Apivar effectiveness in Florida – 3 apiaries -Spring 2012
Source: Gary D Van Cleef, Apiary Inspection Supervisor Region I, Division of Plant Industry, Florida Department of Agriculture
and Consumer Services.
5,99
4,64
0,62
4,12
-
1
2
3
4
5
6
7
8
Apivar (n=30) Control (n=30)
# M
ite
s p
er
10
0 b
ee
s
Mite population before and after Apivar treatment
in comparison with untreated control
Before treatment After treatment
• Perfectly safe for bees and beekeepers
• No significant residues in hive products
Proven safe for more
than 15 years
Safe for bees and queens
Harmless to bees and queens at up to 5 times recommended dose
“The product had no effect on bee
mortality , size of the brood-comb, hive
activity, hive weight or the size of the
honey harvest when used at twice the
indicated dose. ”
Source:http://www.emea.europa.eu/docs/en_GB/document_library/Maximu
m_Residue_Limits_-_Report/2009/11/WC500010373.pdf
“10 strips per [Dadant] hive would not
cause side effects”
“Apivar product therefore has a
considerable safety margin particularly if
we consider its very low risk in the case of
overdose”
Source: T.M. Trower et al, amitraz residues
in honey and bee wax, 2002
High level of safety
in comparison with illegal treatment
• No direct contact with the active
– No vaporization in the hive atmosphere
– Wearing of chemical-resistant gloves is recommended
• Controlled-released disposal
– Residues in hive products, and particularly in honey, are insignificant regardless of when the product is used1.
– Refer to instruction for use on the label as US Sect 18 authorization adds restrictions for the timing of use.
• No excipients introduced that may interact or potentialize other stressors
1: http://dx.doi.org/10.1051/apido:2007038 Martel et al, Acaricide residues in honey and wax after treatment of
honey bee colonies with Apivar or Asuntol 50, Apidologie 38 (2007) 534–544
Low level of residues
Sources: 1/ Acaricide residues in honey and wax after treatment of honey bee colonies with Apivar and Asuntol 50 – Martel et al, 20082/EMA, committee for veterinary medicinal products – amitraz (bees) – summary report - 1999
CHEMO-CHEMICAL PROPERTIES of AMITRAZ
CONSEQUENCES
Highly unstable in acidic environments and highly sensitivity to hydrolysis
Quick degradation in honey = No accumulation in honey
Ex: No residues of amitraz in honey - 10 weeks of treatment with Apivar®
Very low level residues of active substance and components
Not expected to exceed 0.2ppm in honey and 9ppm in honeycomb beeswax
RESIDUES
New-Zealand residues study
Distribution of amitraz and its components in honey(2 Apivar strips per brood chamber– 6 weeks treatment. n= 12
Honey supers added at the removal of the strips)
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
0,00 0,01 0,02 0,03 0,04 0,05 0,06 0,07 0,08 0,09 0,10 0,11 0,12 0,13 0,14 0,15 0,16 0,17 0,18 0,19 0,20
% o
f h
ive
s w
he
re r
esi
du
es
are
de
tect
ab
le
Detected Dose (µg/g)
Maximum residues allowed
in EU in honey
Equivalent to the tolerance
threshold for Sect 18
• No residues (amitraz and components) detected in more than 65% of the hives
• 100% hives show residues dramatically bellow the authorized threshold.
Low level of residues
US Section 18 status
ADDITIONAL PRECAUTIONS
TO SECURE THE QUALITY OF PRODUCTION
– Maximum of 2 treatments per year
(spring and fall treatment)
– May not be used when honey supers are
present
– Honey super cannot be installed until 14
days after strip removal
Instructions for use
Easy to use
Instructions for use
1- Use 2 Apivar® strips per brood chamber
Separate the double rigid strips.
2- Use the strip's die-cut triangle as a hanging hook, or insert a
toothpick or hook in the hole provided.
3- Hang each strip between two comb frames inside the brood
area or the bee cluster, with a minimum distance of two frames
between strips.
Instructions for use
Instructions for use
Insertions of
Strips
End of
treatment
• 2 strips per brood chamber
• Inside the brood area
• Treat all colonies at the same time
• Wear protective gloves
• Remove after a maximum of 56 days
• Do not re-use the strips
• If the bee cluster moves away from
the strips, reposition the strips into
the bee cluster, and leave them in
place for 14 more days before
removal.
6 weeks = one full treatment 2 weeks after treatment
Insert honey
supers
Timing recommendations
• 2 applications per year are possible (if required)
Goal : lower the
infestation rate to
secure honey yield
Goal : lower the
infestation rate to
secure wintering
Practical information #1
Treatment effectiveness
depends of the position of the strips
• Mode of action: The distribution of amitraz in the
colony results from the bees coming into contact
with the strips.
• Recommended positioning :
Place the strips in the brood area (2 strips per brood
chamber) to ensure the highest frequency of contact of
the bees with the strips
Treatment effectiveness
can be increased by feeding bees
• Feeding bees stimulates the colony, which
increases the activity of the honey bees.
• Advice : feeding bees while the Apivar strips
are installed will improve the colony’s health
by:
– Enhancing contact with Apivar strips ,
thereby improving distribution of the
active ingredient inside the colony
– Stimulating new brood development
with fewer mites.
Practical information #2
Treatment effectiveness can be increased by
treating all the colonies of the apiary at the same time
In the colony:
• Adult varroa are present on the back of the foragers
• High frequency of robbing and drifting
• Many exchanges between honeybees and colonies…
including parasitic ones!
Varroa treatment : If all colonies are not treated at the
same time, there is high risk of re-infestation after the
removal of the strips in the treated hives.
Practical information #3
In the colony• Frequent movements of the brood inside
the hive
--> Strips no longer in the area of high activity
--> Less effective distribution of amitraz in the colony
Recommendation for Apivar treatment: • Check the position of the strips during the
treatment or at the end.
• In case of movement of bees inside the beehive away from the strips, reposition the strips into the bee cluster and leave in place for 14 days.
Practical information #4
Treatment effectiveness
can be increased by repositioning the strips
CONVENIENT
ONLY 1 TREATMENT REQUIRED FOR 6 WEEKS OF PROTECTION
USABLE IN SPRING AND IN FALL
PROVEN EFFECTIVENESSUP TO 99% REDUCTION IN MITES IN BROOD
SAFE
RESIDUES LEVELS VERY LOW AND CONTROLLED
NO ACCUMULATION OF RESIDUES IN BEESWAX
SAFE FOR YOUR BEES, BROOD, QUEENS . . .
Apivar®: a new tool to rely on
CAUTION
Apivar® has been approved under Section 18
emergency use exemptions in select states. Apivar
does not have Section 18 approval in all states.
Prior to using this product, contact your local
Department of Agriculture or your Apivar distributor to
determine the status of Section 18 authorization in
your state.
Company
presentation
Honey bee orientated company
• History
– Formed in 2000 after the purchase of Apivar SA shares by Nutritomen.
– Part of Arysta Health and Nutrition Science
• Based in France
• 100% dedicated to beekeeping industry by the development and
marketing of medicines and healthcare products for honeybees and
beekeeping industry
BEEING A KEE PLAYER
FOR THE DEVELOPMENT OF BEEKEEPING INDUSTRY
Our vision
GIVING WORTH
TO HONEYBEES AND BEEKEEPERS
• Our mission : Using our expertise and dynamism to serve the beekeeping industry worldwide by developing healthcare products for colonies and supporting added-value bee products.
• To be a key-player of beekeeping industry, we focus our development on the three pillars of health :
• DIAGNOSIS
• PREVENTION
• TREATMENT
• The involvement of Arysta HNS into pharmaceutical, nutraceutical and cosmeceuticalindustries gives us the expertise to provide the best solutions for the beekeeping industry.
Our DNA
HONEYBEE PASSION
Our team shares a common motivation: to bring to market innovative solutions to
support the beekeeping industry.
TEAM ORIENTED
The team spirit is not only evident among our staff, but also among beekeepers, whose burdens we try to ease with our products.
HIGH QUALITY STANDARDS
Quality is central to our accorder
products as a result of our role as a
veterinary pharmaceutical lab.
All products developed by our
qualified team are tested in the field
to offer efficacy and safety
to colonies and beekeepers.
Sourcing, distribution and formulation of API
for cosmeceuticals and pharmaceuticals
companies
Pharma / cosmetics
LONG ACTING FERTILIZER
Plant nutrition
A company of Arysta Health & Nutrition Science
For more information:
http://www.arysta-hns-corp.com
•HONEYBEE HEALTH : Development and
production of medicine and healthcare
products and add value to bee products.
•PETS AND LIVESTOCK: Development and
manufacturing of medicines, dietary
supplement and healthcare products on
behalf of our customers
•ACTIVES : Distribution of Actives for animal
health companies (vitamins, colistin, …)
Animal Health
