“A Vision of Lifelong Mobility” - Bone & Jointboneandjoint.uwo.ca/documents/Annual Report 2017.pdf · 2020-03-03 · In some cases, early stage disease will appear in our youth

“A Vision of Lifelong Mobility”

ANNUAL REPORT

2017

WESTERN BONE & JOINT INSTITUTE ANNUAL REPORT 2017

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Table of Contents

List of Abbreviations ............................................................................................................................ 3

Acknowledgments ......................................................................................................................... 4

Sponsors ............................................................................................................................................... 4

Key Partners & Core Facilities/Programs ............................................................................................ 4

Message from the Scientific Director .......................................................................................... 6

Section 1.0: Introduction .............................................................................................................. 7

1.1: Why a Focus on Musculoskeletal (MSK) Conditions? ..................................................................... 7

1.2: Bone and Joint Institute (BJI) Overiew ............................................................................................. 8

1.3: BJI Membership ................................................................................................................................ 9

1.4: Governance Structure and Members ............................................................................................... 13

Governing Board ................................................................................................................................ 14

Research & Business Advisory Committee (RBAC) ......................................................................... 15

MSK Operations Committee (MOC) & Executive* Committee (EXEC) ......................................... 16

Communications Committee .............................................................................................................. 19

Seminar Committee ............................................................................................................................ 20

Training and Education Committee ................................................................................................... 21

Trainee Leadership Committee .......................................................................................................... 22

Section 2.0: Operations Report .................................................................................................. 23

2.1: Transdisciplinary Collaborative Research ....................................................................................... 23

2.2: The Seminar & Workshop Series .................................................................................................... 24

Seminars ............................................................................................................................................. 24

Workshops .......................................................................................................................................... 25

2.3: The Catalyst Grant Program ............................................................................................................ 26

2015 Catalyst Grants .......................................................................................................................... 27

2016 Catalyst Grants .......................................................................................................................... 32

2017 Catalyst Grants .......................................................................................................................... 32

2.4: Biennial BJI Research Retreat ......................................................................................................... 33

2.5 Recruitment ...................................................................................................................................... 34

2.6: The Collaborative Training Program in MSK Health Research (CMHR) ...................................... 35

Trainee Awards .................................................................................................................................. 36

Summer Program: .............................................................................................................................. 39

2.7: Research Funds ................................................................................................................................ 40

Grants Supporting National Initiatives ............................................................................................... 42

2.8: Knowledge Translation ................................................................................................................... 44

Strategic Planning Process & Update ................................................................................................. 44

Impacting Clinical Practice Guidelines – A BMJ Rapid Recommendation ....................................... 46

Illustrative Examples of Existing Partnerships .................................................................................. 46

Exemplars of Sponsored Events and Community Outreach .............................................................. 47

Technology Transfer and Commercialization .................................................................................... 50


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Media and Communications ............................................................................................................... 50

Section 3.0: Research Report ..................................................................................................... 52

3.1: Understanding Bone and Joint Diseases - 2017 Feature Publication .............................................. 54

3.2: Innovating in Diagnosis and Evaluation - 2017 Feature Publication .............................................. 56

3.3: Developing and Evaluating Therapies - 2017 Feature Publication ................................................. 58

3.4: Influencing Key Knowledge Users - 2017 Feature Publication ...................................................... 60

Section 4: Financial Report ........................................................................................................ 62

4.1: Cluster Financial Overview ............................................................................................................. 63

4.2: Institute Financial Overview ........................................................................................................... 64

Section 5.0: Summary ................................................................................................................. 65

Appendices ................................................................................................................................... 66

Appendix A – BJI Faculty Membership List .......................................................................................... 66

Appendix B – BJI Trainee and Staff Membership List .......................................................................... 71

Appendix C – Publications ..................................................................................................................... 76

List of Abbreviations

ADEISS Additive Design in Surgical Solutions Centre

BJI Western’s Bone and Joint Institute

BOG Governing Board

CIHR Canadian Institutes of Health Research

Cluster Western’s Cluster of Research Excellence in MSK Health

CMHR Collaborative Training Program in Musculoskeletal Health Research

ComC Communications Committee

EXEC Executive Committee

HULC Roth McFarlane Hand and Upper Limb Centre

MOC MSK Operations Committee

MSK Musculoskeletal

RBAC Research and Business Advisory Committee

SemC Seminars Committee

TEC Training and Education Committee

TLC Trainee Leadership Committee

WOBL Wolf Orthopaedic Biomechanics Laboratory


4

Acknowledgments

Sponsors

FACULTY OF ENGINEERING

FACULTY OF HEALTH SCIENCES

FACULTY OF SCIENCE

FACULTY OF SOCIAL SCIENCE

LAWSON HEALTH RESEARCH INSTITUTE

OFFICE OF THE PRESIDENT – WESTERN UNIVERSITY

SCHULICH SCHOOL OF MEDICINE & DENTISTRY

Key Partners & Core Facilities/Programs

ARTHRITIS ALLIANCE CANADA

ADDITIVE DESIGN IN SURGICAL SOLUTIONS CENTRE (ADEISS)

BIOMECHANICS & NOVEL TECHNOLOGY LABORATORIES • Bioengineering Research Laboratory at HULC

• Facility for Biomedical Device Design and Fabrication

• MSK Biomechanics Laboratory

• Organic Mechatronics and Smart Materials Laboratory

• Wearable Biomechatronics Laboratory

• Wolf Orthopaedic Biomechanics Laboratory (WOBL)

BIOMEDICAL IMAGING RESEARCH CENTRE (BIRC)

CANADIAN CENTRE FOR ACTIVITY AND AGING

CLINICAL OUTCOMES LABORATORIES • Pain and Quality of Life Integrative Research Laboratory (PIRL)

• HULC Clinical Research Laboratory

• Advancement of MSK Health Research Facility at Fowler Kennedy

COLLABORATIVE TRAINING PROGRAM IN MUSCULOSKELETAL HEALTH RESEARCH

EMPOWER HEALTH RESEARCH INC.

JL RETIREMENT LIVING

LONDON HEALTH SCIENCES CENTRE • Arthroplasty Clinical Unit

• Canadian Surgical Technologies & Advanced Robotics (C-STAR)

• Dr. Sandy Kirkley Centre for Musculoskeletal Research

• Master of Science in Surgery Program

• Orthopaedic Research Lab

• Orthopaedic Spine Centre

• Rorabeck Bourne Joint Replacement Clinic

• Spine Clinical Unit

• Fowler Kennedy Sport Medicine Clinic

• Trauma Clinical Unit

MSK IMAGING LABORATORIES • Pre-Clinical Imaging Research Centre (PIRC)

• Load-bearing Imaging, Biomechanics and Clinical Orthopaedics Research (LIBCOR) in

WOBL

• Sustainable Archaeology Collaborative Initiative


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ONTARIO INSTITUTE OF REGENERATIVE MEDICINE

RESEARCH WESTERN

MEDICAL INNOVATION FELLOWSHIPS PROGRAM

RICHARD IVEY SCHOOL OF BUSINESS • Ivey International Centre for Health Innovation

ROBARTS RESEARCH INSTITUTE

SCIENCE FACILITIES & LABORATORIES • Western Nanofabrication Facility

• Surface Science Western

• Laboratory for Biomaterial Synthesis

• Integrated Microscopy Facility at the Western Biotron

SKELETAL BIOLOGY LABORATORIES • Biomaterials Science Laboratory

• Mammalian Embryonic Stem Cell Laboratory

• Photon Technology International—Horiba Fluorescence Imaging Core Facility

ST. JOSEPH’S HEALTH CARE LONDON • Roth McFarlane Hand and Upper Limb Centre (HULC)

• Rheumatology Centre

THE ARTHRITIS SOCIETY

WORLDISCOVERIES® BUSINESS DEVELOPMENT OFFICE


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Message from the Scientific Director

Dr. David Holdsworth

This year was highly focused on engagement, building relationships

and expanding collaborative opportunities internally and externally.

There continues to be a great appreciation for the need to work

together as we tackle needs and gaps in the area of musculoskeletal

(MSK) health. With such complicated conditions – that crossover

and affect so many systems of the human body, and aspects of

people’s lives – a comprehensive approach is necessary. Bringing

together multiple experts across disciplines will result in discoveries

and innovations that will benefit millions of Canadians.

Events like our Biennial Research Retreat hosted in May enabled

crucial knowledge sharing and reflection on ‘where we are’ and

‘how we are doing’. Members provided insight that contributed

greatly to quality improvement of our activities and informed

preliminary examination of future direction. Building on this insight, we held a series of strategic

planning sessions with members and partners to have an in-depth exploration of key elements and

the future of the Institute. We look forward to 2018, with a plan to focus and streamline our efforts,

submit coordinated applications for major funding, advance the involvement of trainees in

research, educational, and collaborative opportunities internally and beyond, and expand our

facilities and capacity.

It is a pleasure to share with you, in this 2017 annual report, highlights of the astonishing

achievements of our members. The will to strengthen and grow the Institute and its activities, as

well as raise awareness about the

relevance of our cause and our

unique approach has never been

more imperative. We are seeking

out broader audiences and looking

to enhance our interactions with

the public, industry, and

government. In doing so, our

research is more likely to have a

positive and more immediate

impact on our healthcare system,

social-care systems and economy –

and most importantly result in

better lived experiences for people

who suffer from MSK conditions.

Photo 1 – Informal networking among participants at the BJI Research Retreat


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Section 1.0: Introduction

1.1: Why a Focus on Musculoskeletal (MSK) Conditions?

Mobility and self-care for people of all ages is highly linked to their MSK health. People’s capacity

to actively participate in domestic, work/school, community, and social activities is often reduced

for those who live with MSK conditions, despite their efforts to adapt. In fact, MSK conditions

are:

The number of Canadians with MSK conditions is predicted to increase to more than 15 million

by 20313. These conditions afflict the young and the mature alike, as a result of trauma such as

falls, work/sports injuries, or motor vehicle accidents. In some cases, early stage disease will

appear in our youth and progress to end-stages during adulthood. As the 3rd most common

diagnostic category in Canada, MSK conditions have the highest total direct costs to the healthcare

system, and MSK-related disability costs are the single largest cost category associated with any

chronic disease4,5. Beyond direct costs are the substantial indirect costs to patients and society. If

we examine a trauma-related MSK condition such as bone fractures due to osteoporosis, Canadian

direct and indirect healthcare costs reached $4.6 billion in 20167. Likewise, a chronic and

progressive MSK disease like osteoarthritis has been projected to result in Canadian direct and

indirect healthcare costs of more than $120 billion by 20306.

With such a high impact

on people and our

economy, we have an

obligation to invest in

MSK research studies

that are a high priority for

our population and our

systems. The Institute is bringing together key experts across the University, the public realm, and

related industries to identify the most relevant needs and gaps, to examine diseases, and to assess

existing prevention and care processes.

1. http://www.thelancet.com/themed/global-burden-of-disease - in Lancet in 2016 (Global Burden of Disease Study 2015)

2. http://www.who.int/bulletin/volumes/81/9/Woolf/pdf

3. Canadian Orthopaedic Care Strategy Group. (2010). Backgrounder Report: Building a Collective Policy Agenda for Musculoskeletal Health and Mobility.

4. The Cost of Chronic Disease in Canada, 2004

5. Public Health Agency of Canada (2009). Investing in Prevention – The Economic Perspective, (last accessed Aug 7, 2014)

6. http://can.arthritisalliance.ca/about-2/can-s-history-as-an-nce/news-archive/the-impact-of-arthritis-in-canada-today-and-over-the-next-30-years

7. Hopkins RB, Burke N, Von Keyserlingk C, Leslie WD, Morin SN, Adachi JD, et al. The current economic burden of illness of osteoporosis in Canada.

Osteoporos Int. 2016

http://www.thelancet.com/themed/global-burden-of-disease

http://can.arthritisalliance.ca/about-2/can-s-history-as-an-nce/news-archive/the-impact-of-arthritis-in-canada-today-and-over-the-next-30-years


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1.2: Bone and Joint Institute (BJI) Overiew

Now in its third year of operations, the BJI

continues to mobilize people around its vision

of lifelong mobility. By enabling collaboration

among researchers, trainees, consumers and

partners, the goal is to put into action the

Institute’s core values. Through collaboration

and knowledge translation, we have the means

to gain fresh comprehensive perspectives and

establish new techniques that will accelerate

successful innovation in many areas of: 1) basic

biological and biomedical; 2) physical sciences

and engineering; 3) clinical and health services;

and 4) population and community health.

By combining various scientific approaches, our

researchers can expand our understanding of the

initiation and progression of joint degeneration, bone

loss, and the role of abnormal biomechanics. They can

launch and support initiatives that help to: 1) prevent

the onset or progression of MSK conditions; 2)

enhance appropriate bone growth and encourage

implant integration, and 3) develop novel and creative

patient-centered assessment tools as well as

preventive and rehabilitative therapies/assistive

devices. By examining cost-effectiveness in relation to

clinical outcomes, best-practices can be established.

Furthermore, the development and transfer of intellectual property to the right partners can enable

industries to flourish and contribute to the Canadian economy, and eventually, stimulate new

research advancements.

Finally, an integral and vital component of the

Institute is the involvement of our future leaders via

the Collaborative Training Program in

Musculoskeletal Health Research (CMHR), soon to

be renamed the Collaborative Specialization in

Musculoskeletal Health Research. With dedication to

the trainee experience, BJI creates an environment

that enables both investigators and partners to

contribute to the development of trainees’ skills and

position them to be assets to society all along their

career path. By unlocking their potential and

• Lifelong mobility.

Vision

• To lead transdisciplinary research, innovation, and education in MSK health.

Mission

• Collaboration

• Knowledge translation

• Excellence in innovation

• Education & research training

Core Values

Photo 2 - Strategic planning session with key stakeholders

Photo 3 – BJI trainees as they prepared for the Arthritis

Society Tour of BJI facilities (see section 2.8).


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acknowledging their contribution, the enthusiasm and “outside the box thinking” they bring is truly

a rich and invaluable component of Institute success.

1.3: BJI Membership

BJI membership grew from 185 people to 254 in 2017 with 108 faculty, 89 CMHR trainees, 18

other trainees, and 39 partner/collaborator/staff members (Appendix A – list of faculty members

& B – list of non-faculty members). Not all trainees and non-faculty members who conducted or

supported MSK research under the supervision of BJI faculty members were registered as official

Institute members. The graphics below display the percentage of the types of members, percentage

of members in each partner Faculty, faculty members’ alignment to BJI research themes, and the

comprehensive expertise and skills they apply to those themes.

145

185

254

0

50

100

150

200

250

300

2015 2016 2017

Total # of Members Over Time

Photo 4 – A group of BJI representatives who participated in the Walk for Arthritis – an event to raise

awareness and to raise funds to find a cure (see section 2.8).

76

93

108

53

62

89

6

20 18

10 10

39

0

20

40

60

80

100

120

2015 2016 2017

BJI Membership Over Time

Faculty CMHR Trainees Other Trainees Partners & Staff


10

16 16

23

15

4

35

21

28

42

23

811

14

20

117 8

11 12

2824

10

24 25

9

26

40

127

22

12 13

23

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Data presented as the number of BJI Faculty members by self-identitfied reasearch areas.

Comprehensive Expertise Applied to the BJI Research Themes

Faculty, 108, 43%

CMHR Trainee,

89, 35%

Trainee, 18,

7%

Partners/Collaborators/Staff, 39, 15%

Type of BJI Members

Schulich,

122, 54%Health Sciences, 46, 20%

Engineering,

42, 18%

Science, 14,

6%Social Science, 4, 2%

BJI Members' Home Faculty

Understanding bone

and joint diseases,

29%

Innovating in diagnosis

& evaluation, 23%

Developing & evaluating

new therapies, 31%

Influencing key

knowledge users, 17%

Faculty Members Distribution Across

BJI Primary Objectives

52

35

49

12

47

3830

9

Basic biological

& biomedical

Physical

sciences &

engineering

Clinical &

health services

Population &

community

health

Members Distribution Across

BJI Research Themes

Faculty Trainees


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Prestigious awards and recognitions held in 2017 by BJI Faculty members

RESEARCH CHAIRS

▪ Michele Crites Battié – Western Research Chair - MSK Exercise Mobility and Health (WRC)

▪ Frank Beier - Musculoskeletal Research (CRC Tier 1)

▪ Trevor Birmingham - Musculoskeletal Rehabilitation (CRC Tier 1)

▪ Mikko Karttunen - Materials and Biomaterials Science (CRC Tier 1)

▪ Dale Laird – Gap Junctions and Disease (CRC Tier 1)

▪ Joy MacDermid – Gender in Measurement & Rehab of MSK Work Disability (CIHR)

▪ Rajnikant Patel – Advanced Robotics and Control (CRC Tier 1)

▪ Kevin Shoemaker – Integrative Physiology of Exercise and Health (CRC Tier 1)

ENDOWED/INDUSTRY CHAIRS

▪ Blaine Chronik – IRC in Magnetic Resonance Systems Development

▪ David Holdsworth – Dr. Sandy Kirkley Chair in MSK Research

▪ James Johnson – Graham King Musculoskeletal Research Chair

▪ Joy MacDermid – James Roth Research Chair in MSK Measurement & Knowledge Translation

▪ Steven MacDonald – J.C. Kennedy Chair in Orthopaedic Surgery

▪ Emil Schemitsch – Richard Ivey Chair of the Department of Surgery

ROYAL SOCIETY OF CANADA FELLOWS

▪ Rajni Patel – Electrical & Computer Engineering

▪ Terry Peters – Medical Biophysics

CANADIAN ACADEMY OF HEALTH SCIENCES FELLOWS

▪ Dale Laird – Anatomy and Cell Biology ▪ Joy MacDermid – Physical Therapy

▪ Kevin Shoemaker – Kinesiology

NATIONAL AWARD

▪ Elizabeth Gillies – NSERC E.W.R. Steacie Memorial Fellowship

NEW INVESTIGATOR / EARLY CAREER RESEARCHER AWARD

▪ Cheryle Séguin – CIHR and Ontario Ministry of Research and Innovation

▪ Matthew Teeter – Ontario Ministry of Research and Innovation

▪ Lillian Barra – Arthritis Society

▪ Louis Ferreira – Ontario Ministry of Research and Innovation

▪ Al Getgood – Ontario Ministry of Research and Innovation

▪ Matthew Teeter – Ontario Ministry of Research and Innovation

▪ Ana Luisa Trejos - Ontario Ministry of Research and Innovation

▪ Dave Walton – Ontario Ministry of Research and Innovation and the Canadian Pain Society


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DISTINGUISHED UNIVERSITY PROFESSOR

▪ S. Jeffrey Dixon – Professor, Department of Physiology and Pharmacology (2015)

▪ Rajni Patel – Professor, Department of Electrical & Computer Engineering (2005)

▪ Kevin Shoemaker – Professor, School of Kinesiology (2016)

FACULTY SCHOLARS AWARD

▪ Grace Parraga – Medical Biophysics (2016-2018)

▪ Elizabeth Gillies – Chemical & Biochemical Engineering (2016-2018)

▪ Dave Walton – Physical Therapy (2017-2019)

Photo 7 - BJI members as they refined the strategic plan.

Photo 5 - A wearable tremor suppression glove prototype. Photo 6 - University leaders as they interacted with BJI

external advisors/partners at the BJI Research Retreat.


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1.4: Governance Structure and Members

The governance structure is in place to support Institute members and activities. Committee

members serve on a volunteer basis to promote the BJI’s vision and to support program and

activities. The Governing Board (BOG) oversees the overall function of the Institute and is

responsible for providing strategic advice, helping with fundraising and partnership development,

as well as assessing performance. The Research and Business Advisory Committee (RBAC)

provides direction with regard to scientific priorities, business development, and

commercialization opportunities locally, nationally, and internationally. The Executive

Committee (EXEC) manages and supports day-to-day activities. It plays a critical role in

requesting input/feedback from the Operations Committee and directing staff as needed. The MSK

Operations Committee (MOC) provides leadership and two-way communication with Institute

members and senior leaders within their Faculty/sector. MOC is responsible for ensuring that

programs and activities are implemented to advance Institute objectives.

The Communications Committee (ComC) facilitates knowledge dissemination to the community

and stakeholders. They support the publication of membership achievements, activities, and

programs. The Seminar Committee (SemC) organizes and implements a seminar series and

workshops to expose the MSK community to a variety of research topics that are relevant to

multiple disciplines and to encourage the exchange of ideas that may stimulate new collaborations,

innovations, and solutions. The Training and Education Committee (TEC) fosters the integration

and convergence of disciplines through the Collaborative Training Program in MSK Health

(CMHR) that engages and supports Western trainees (undergraduate, graduate, postdoctoral, and

clinician scientists in training) from multiple Faculties through courses/seminars, communication

and career development workshops, Transdisciplinary Training Awards, stipend enhancements,

and collaborative linkages/partnerships. New in 2017, the Trainee Leadership Committee (TLC)

is dedicated to engaging trainees interested in MSK health research by focusing on integration and

convergence of disciplines through participation in academic and social activities.

Governing Board

Research &Business Advisory

Committee

Operations Committee

Training & Education Committee

Trainee Leadership Committee

Special Ad-Hoc

Committees

Communications Committee

Seminar Committee

Executive Committee


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Governing Board

Cecile Rorabeck

Chair

Professor Emeritus; former

Chair of Orthopaedic Surgery

Linda Miller

Vice-Chair

Vice-Provost (Graduate and

Postdoctoral Studies)

Robert Anderson

Dean of Social Science John Capone

Vice-President (research)

Kelly Cole

Vice-President (external)

Pauline Barmby

Acting Dean of Science

Ray Elliott

Industry Representative

S. Jayne Garland

Dean of Health Sciences

David Hill

LHRI Director

Andrew Hrymak

Dean of Engineering

Nik Knowles

Trainee Representative

Marlys Koschinsky

Robarts Institute Director

Anne Lyddiatt

Consumer Representative

Steve MacDonald

Chair Ortho. Surgery

Michael Strong

Dean of Schulich

Ex-Officio Title

Trevor Birmingham BJI Director of Training and Education

Jeffrey Dixon BJI Director of Operations

David Holdsworth BJI Scientific Director

Jann Paquette-Warren BJI Manager of Research & Innovation

Secretary of the Governing Board Shannon Woodhouse BJI Operations Manager


15

Research & Business Advisory Committee (RBAC)

Dave Barrett

Chair

Executive Director of the Ivey International Centre for Health Innovation

John Coderre

Vice-Chair


Clifton Bingham

Director of Johns Hopkins

Arthritis Centre

Jennifer Boyle


Lisa Cechetto

Executive Director of

WORLDiscoveries

Ray Elliott

Industry & BJI Board

Representative

Kurt Hankenson

Associate Director of

Laboratory for Comparative

Orthopaedic Research

Cathie Hofstetter


David Holdsworth

BJI Scientific Director

Reiza Rayman

Industry Representative

Carl Richards

Director of the McMaster

Immunology Research

Centre

Ron Zernicke

Centre for Hip Health and

Mobility

Jann Paquette-Warren

Manager Research &

Innovation BJI


16

MSK Operations Committee (MOC) & Executive* Committee (EXEC)

MOC Member Title Home Faculty/ Department BJI Research Themes

Jeffrey Dixon* Chair of MOC

Director of Operations

Schulich School of

Medicine & Dentistry

Representative

Schulich School of Medicine

& Dentistry – Department of

Physiology and Pharmacology

& Dentistry

Basic biological and

biomedical

Baraa Al-Khazraji Post-Doctoral Fellow

Representative

Faculty of Health Sciences –

School of Kinesiology

Clinical and health

services

Frank Beier Schulich School of

Medicine & Dentistry

Representative

Recruitment Working

Group Lead


& Dentistry - Department of

Physiology & Pharmacology


biomedical

Trevor Birmingham* Director of Training &

Education

Co-Director of CMHR

Co-Chair of Training

& Education

Committee

Recruitment Working

Group Lead

Health Sciences

Representative

Faculty of Health Sciences -

School of Physical Therapy

Clinical and health

services

Alan Getgood Clinician

Representative

Schulich School of

Medicine and

Dentistry

Representative

Member at Large


and Dentistry – Department of

Surgery

Clinical and health

services

Elizabeth Gillies

Faculty of Science

Representative

Faculty of Science –

Department of Chemistry

(home)

Faculty of Engineering –

Chemical & Biochemical

Engineering (50:50 joint

appointment)

Physical sciences and

engineering


17


David Holdsworth* Scientific Director

BJI Representative

Schulich School of

Medicine and

Dentistry

Representative


and Dentistry – Departments

of Medical Biophysics and

Surgery


biomedical

Joy MacDermid Recruitment Group

Lead

Member at Large

Health Sciences

Representative


School of Physical Therapy;


& Dentistry

Clinical and health

services; Population and

community health

Jacquelyn Marsh

BJI Early Career

Research in MSK

Health Economics

Faculty of Health

Sciences

Representative


School of Physical Therapy

Clinical and health

services; Population and

community health

Andrew Nelson Faculty of Social

Science Representative

Faculty of Social Science –

Department of Anthropology;

Faculty of Science –

Department of Chemistry

Population and

community health; Basic

biological and

biomedical; Physical

sciences and engineering

Aaron Price Faculty of Engineering

Representative


Department of Mechanical and

Materials Engineering


engineering

Cheryle Séguin* Co-Director of CMHR

Co-Chair of the

Training & Education

Committee

Recruitment Working

Group Lead

Schulich School of

Medicine and

Dentistry

Representative


and Dentistry - Department of

Physiology & Pharmacology


biomedical


18


Ana Luisa Trejos Chair of the Seminars

Committee

Recruitment Group

Lead

Faculty of Engineering

Representative


Department of Electrical and

Computer Engineering


engineering

Matthew Veras

Trainee Representative

Trainee Leadership

Committee Chair


& Dentistry


biomedical

Dave Walton

Communications

Committee Chair

Faculty of Health

Sciences

Representative

Faculty of Health Sciences

Clinical and health

services

NON-VOTING MEMBERS

Patrick Callaghan RD&S Financial

Officer

Western Research

Development Service

---

Samantha Mundy* Administrative

Assistant, Ex-Officio

BJI ---

Jann Paquette-Warren* Manager of Research

& Innovation, Ex-

Officio

BJI ---

Shannon Woodhouse* Operations Manager,

Ex-Officio

BJI ---


19

Communications Committee

Dave Walton

Chair

Health Sciences

Jeffrey Dixon

Interim Chair

Schulich

Frank Beier

Faculty Rep

Schulich

Pavlos Bobos

Trainee Rep

Health Sciences

Helen Connell

Associate VP

Western Coms & PA

Mamadou Diop

Faculty Rep

Schulich

Morgan Jennings

Trainee Rep

Health Sciences

Emily Lalone

Faculty Rep

Engineering

Katherine Willmore

Faculty Rep

Schulich


Manager R & I

BJI

Shannon Woodhouse

Operations Manager

BJI

Photo 8 – CTV reported on the CIHR awarded funds that will

support spine disease research at BJI.

Photo 9 - BJI members engaged with patients and local

community members by hosting a “live lab” during the Walk

for Arthritis.


20

Seminar Committee

Ana Luisa Trejos

Chair

Engineering

Silvia Penula

Faculty Rep

Schulich

Matthew Veras

Trainee Rep

Schulich

Jackie Sadi

Faculty Rep

Health Sciences


Manager R & I

BJI

Shannon Woodhouse

Operations Manager

BJI

Photo 10 – Series of images from seminars by external speakers from academia, industry and other sectors.


21

Training and Education Committee

Cheryle Séguin

Co-Chair

Schulich

Trevor Birmingham

Co-Chair

Health Sciences

Ayten Hijazi

Trainee Rep

Schulich

Brent Lanting

Faculty Rep

Schulich

Tim Burkhart

Faculty Rep

Engineering

Jim Dickey

Faculty Rep

Health Sciences

Nik Knowles

Trainee Rep

Engineering

Andrew Nelson

Faculty Rep

Social Science

Samantha Mundy

Program Assistant

BJI


Manager R & I

BJI

Photo 11 - Images of sample trainees events including pannel discussions and poster sessions.


22

Trainee Leadership Committee

Baraa Al-Khazarji

Vice-Chair, Post-Doc

Health Sciences

Matthew Veras

Chair, PhD Trainee

Schulich

Nadia Sharma

Vice-Chair, Master’s Trainee

Engineering

Hayden Atkinson

PhD Trainee

Health Sciences

Pavlos Bobos

PhD Trainee

Health Sciences

Ayten Hijazi

TEC Rep, Post-Doc

Schulich

Morgan Jennings

Master’s Trainee

Health Sciences

Brandon Kim

Master’s Trainee

Schulich

Hisham Kamoun

Master’s Trainee

Engineering

Nikolas Knowles

PhD Trainee

Engineering

Samantha Mundy

Program Assistant

BJI

Photo 12 – BJI trainees organized and implemented events for people of all ages and with different interests related to MSK conditions.


23

Section 2.0: Operations Report

2.1: Transdisciplinary Collaborative Research

Transdisciplinary collaboration among Institute members is expanding. Below is an image of co-

authored MSK-related research articles published by BJI members in 2017 (Note: This analysis was

prepared using the Science of

Science Tool (Sci2), Indiana

University and SciTech

Strategies -

https://sci2.cns.iu.edu.) Each

circle signifies an author and

each line symbolises a co-

authored manuscript. This

provides a visual

representation of the degree

of collaboration among

Institute members. When

compared to the degree of

collaboration in 2016, the

number of connections

among authors has grown

and the number of

independent or close-ended

circle (authors) has

decreased.

Furthermore, BJI members

participate in significant

international collaborations

for high impact research and

they serve as global opinion

leaders. Below is a list of

selected publications from

2017 that exemplify the

outcomes of these important

activities: publications in

journals such as Lancet and

Cell; three publications in

Annals of the Rheumatic

Diseases (the highest impact

journal in the field of

rheumatology); a

publication in the European Spine Journal (which received the 2017 Prize in Bioengineering

Science from the International Society for the Study of the Lumbar Spine); and a timely editorial

in the journal Arthritis & Rheumatology.

Degree of Collaboration 2016

Degree of Collaboration 2017

https://sci2.cns.iu.edu/


24

1. Appleton, C. T., Hawker G., A., Hill C., L., & Pope J., E. (2017). Editorial: “Weighing in” on the

Framingham Osteoarthritis Study: Measuring Biomechanical and Metabolic Contributions to Osteoarthritis.

Arthritis & Rheumatology, 69(6), 1127-1130. doi:10.1002/art.40089

2. Bhandari, M., Devereaux, P. J., Guyatt, G., Thabane, L., Walter, S. D., Heetveld, M. J., Jeray, K. J., Liew,

S., Schemitsch, E. H., Tornetta, P., Della Rocca, G. J., McCormack, R., Oliver, T. M., Segers, M. J. M.,

Rangan, A., Richardson, M., Sprague, S., Slobogean, G. P., Scott, T., Garibaldi, A., Zhou, Q., Heels-Ansdell,

D., Viveiros, H., Zielinski, S. M., Van Lieshout, E. M. M., Johal, H., Hanusch, B. C., & Swiontkowski, M.

(2017). Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre,

randomised controlled trial. Lancet, 389(10078), 1519-1527. doi:10.1016/s0140-6736(17)30066-1

3. Jamaludin, A., Lootus, M., Kadir, T., Zisserman, A., Urban, J., Battie, M. C., Fairbank, J., McCall, I., &

Genodisc, C. (2017). ISSLS PRIZE IN BIOENGINEERING SCIENCE 2017: Automation of reading of

radiological features from magnetic resonance images (MRIs) of the lumbar spine without human

intervention is comparable with an expert radiologist. European Spine Journal, 26(5), 1374-1383.

doi:10.1007/s00586-017-4956-3

4. Laird, D. W., Naus, C. C., & Lampe, P. D. (2017). SnapShot: Connexins and Disease. Cell, 170(6), 1260-

1260.e1261. doi:10.1016/j.cell.2017.08.034

5. Ombrello, M. J., Arthur, V. L., Remmers, E. F., Hinks, A., Tachmazidou, I., Grom, A. A., Foell, D., Martini,

A., Gattorno, M., Ozen, S., Prahalad, S., Zeft, A. S., Bohnsack, J. F., Ilowite, N. T., Mellins, E. D., Russo,

R., Len, C., Hilario, M. O. E., Oliveira, S., Yeung, R. S. M., Rosenberg, A. M., Wedderburn, L. R., Anton,

J., Haas, J. P., Rosen-Wolff, A., Minden, K., Tenbrock, K., Demirkaya, E., Cobb, J., Baskin, E., Signa, S.,

Shuldiner, E., Duerr, R. H., Achkar, J. P., Kamboh, M. I., Kaufman, K. M., Kottyan, L. C., Pinto, D., Scherer,

S. W., Alarcon-Riquelme, M. E., Docampo, E., Estivill, X., Gul, A., Langefeld, C. D., Thompson, S., Zeggini,

E., Kastner, D. L., Woo, P., Thomson, W., British Soc Pediat Adolescent, R., Inception Cohort Newly

Diagnosed, P., Childhood Arthrit Prospective, S., Randomized Placebo Phase Study, R., Sparks-Childhood

Arthrit, R., & Biologically Based Outcome, P. (2017). Genetic architecture distinguishes systemic juvenile

idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications.

Annals of the Rheumatic Diseases, 76(5). doi:10.1136/annrheumdis-2016-210324

6. Sritharan, P., Lin, Y. C., Richardson, S. E., Crossley, K. M., Birmingham, T. B., & Pandy, M. G. (2017).

Musculoskeletal loading in the symptomatic and asymptomatic knees of middle-aged osteoarthritis patients.

Journal of Orthopaedic Research, 35(2), 321-330. doi:10.1002/jor.23264

7. Ter Haar, N. M., Annink, K. V., Al-Mayouf, S. M., Amaryan, G., Anton, J., Barron, K. S., Benseler, S. M.,

Brogan, P. A., Cantarini, L., Cattalini, M., Cochino, A. V., De Benedetti, F., Dedeoglu, F., De Jesus, A. A.,

Alberighi, O. D. C., Demirkaya, E., Dolezalova, P., Durrant, K. L., Fabio, G., Gallizzi, R., Goldbach-

Mansky, R., Hachulla, E., Hentgen, V., Herlin, T., Hofer, M., Hoffman, H. M., Insalaco, A., Jansson, A. F.,

Kallinich, T., Kone-Paut, I., Kozlova, A., Kuemmerle-Deschner, J. B., Lachmann, H. J., Laxer, R. M.,

Martini, A., Nielsen, S., Nikishina, I., Ombrello, A. K., Ozen, S., Papadopoulou-Alataki, E., Quartier, P.,

Rigante, D., Russo, R., Simon, A., Trachana, M., Uziel, Y., Ravelli, A., Gattorno, M., & Frenkel, J. (2017).

Development of the autoinflammatory disease damage index (ADDI). Annals of the Rheumatic Diseases, 76(5). doi:10.1136/annrheumdis-2016-210092

8. Valentini, G., Iudici, M., Walker, U. A., Jaeger, V. K., Baron, M., Carreira, P., Czirjak, L., Denton, C. P.,

Distler, O., Hachulla, E., Herrick, A. L., KowaI-Bielecka, O., Pope, J., Muller-Ladner, U., Riemekasten, G.,

Avouac, J., Frerix, M., Jordan, S., Minier, T., Siegert, E., Ong, V. H., Vettori, S., & Allanore, Y. (2017). The

European Scleroderma Trials and Research group (EUSTAR) task force for the development of revised

activity criteria for systemic sclerosis: derivation and validation of a preliminarily revised EUSTAR activity

index. Annals of the Rheumatic Diseases, 76(1), 270-276. doi:10.1136/annrheumdis-2016-209768

2.2: The Seminar & Workshop Series

Seminars

The Seminar Committee solicited speaker suggestions from members and invited 12

internationally recognized MSK experts to deliver seminars that would inspire the exchange of

ideas and new collaborative initiatives. The public seminar talks were co-hosted by a BJI faculty


25

and trainee member and were followed by a lunch session with trainees interested in further

exploring the topic and related career opportunities. When appropriate, the hosts facilitated tours /

individual meetings with members who had a particular interest in the guest’s expertise. To better

understand the value of seminars, a participant evaluation tool to be completed immediately

following seminars was implemented. Evaluation results will inform improvements to the

committee’s activities in 2018.

Below is a list of the 2017 speakers and topics:

Date Speaker & Affiliation Seminar Title

17/01/17 Dr. Scott Banks

University of Florida Dynamic Radiographic Measurement of Skeletal Kinematics

21/02/17 Dr. Sharmila Majumdar

University of California, San

Francisco

Morphological and Quantitative Musculoskeletal Imaging

17/03/17 Dr. Carlo Menon

Simon Fraser University

Unobtrusive Wearable Robotic Technologies Based on

Functional Materials for Assisting with Motor Impairments

21/03/17 Dr. Guy Trudel

University of Ottawa

Detecting the Pores of Osteoporosis: 3D Imaging as a Window

on Bone Remodeling

12/04/17 Dr. Michele Crites Battié

University of Alberta

The Twin Spine Study - Elucidating Common Degenerative

Conditions

24/05/17 Dr. Theresa Anna Guise

Indiana University

Muscle Function Matters: Role of the Tumor-bone

Microenvironment in Regulation of Muscle Function in Cancer

01/06/17 Dr. Cosimo De Bari

University of Aberdeen

Messenchymal Stem Cells find their Niche in Cell Therapy for

Arthritis

28/07/17 Dr. George Bou-Gharios

University of Liverpool

Transgenic Models to Manipulate Metallo-Proteinases: The

Effect on Skeletal Development and Maintenance

05/09/17 Dr. Ceilia Helena de Azevedo

Gouveia Ferreira

Institute of Biomedical Sciences

University of Sāo Paulo

Is the Skeleton a Site for Thyroid Hormone-Sympathetic

Nervous System Interaction?

6/09/17 Dr. Joseph Stains

University of Maryland

Connexin 43 Gap Junctions and the Control of

Osteoblastogenesis

19/10/17 Anne Vivian Scott

BKin Technologies Robotics and Industry Engagement

21/11/17 Sowmya Viswnanathan

University Health Network

Mesenchymal Stromal Cells and Monocytes/Macrophages as

Anti-Inflammatory Therapeutic Approaches for Osteoarthritis

Workshops

Topic-specific workshops identified during the 2016 Town Hall were developed and

incorporated into the 2017 Biennial Research Retreat in May or discussed at the retreat during

the breakfast networking sessions to identify potential hosts, dates, and learning objectives.

Postdoctoral fellow Dr. Anusha Ratneswaran conceptualized and organized the first BJI Young

Investigator Forum on Preclinical Musculoskeletal Health Research in collaboration with

her peers. This event – by trainees for trainees – was implemented on June 5, 2017 and attracted

over 60 participants from London, Guelph, and Toronto. It featured a mix of international,

Canadian, and local trainee speakers from various disciplines, including biologists, engineers and

chemists. A variety of topics were covered in feature talks, such as models of musculoskeletal


26

diseases, novel drug delivery approaches, and

molecular mechanisms driving bone and joint

diseases. One of the most exciting parts of the day was

the enthusiastic discussion after each talk, which

culminated with a panel discussion on translational

musculoskeletal research. Feedback from participants

was extremely positive, suggesting a need for similar

events in the future. In the summer of 2017, Jeff

VanHeumen - Business Development Manager for

Southwestern Ontario with the Ontario Centres of

Excellence (OCE), led a workshop hosted by BJI

members Yara Hosein (Post-Doc Trainee) regarding

OCE Voucher for Innovation and Productivity (VIP)

funding programs including VIP I, VIP II, and Talent Edge. OCE assists university-based

researchers to commercialize innovation in

partnership with Ontario industries (http://www.oce

ontario.org/). The OCE can assist researchers in

identifying potential industry partners, which is a

mandatory component of the funding programs. Dr.

VanHeumen started the workshop with an overview

of the OCE programs, but the majority of the session

was devoted to practical detail on initiating,

developing and submitting an application. The

practical work included accessing the OCE portal to

use existing examples. There was a good open

discussion with the attendees about potential project

and their alignment to the programs. There was wide

interest in the workshop and requests to repeat the

workshop in 2018 were made by those who

encountered attendance conflicts in 2017. Finally,

brainstorming and grant development sessions

were implemented to support team integration and

the preparation of collaborative proposals for major

grant competitions.

2.3: The Catalyst Grant Program

The purpose of the Catalyst Grant Program is to

support the initiation of innovative, high-impact,

and early-stage projects and enable the

leveraging of external funding. The work of the

2015 inaugural competition awardees was

featured at the BJI Research Retreat in May 2017.

Reports to date indicate that the catalyst grants of

2015 resulted in 2 publications, over 15

conference poster/oral presentations, and more

than 7 manuscripts are reported as under


27

development or submitted (results pending). The

grants were leveraged to secure additional funds

from various foundations or agencies, to obtain

dedicated laboratory space or better access to the

population of interest, and to better inform and

position funding proposals (results pending) to

continue this work.

Both 2015 and 2016 teams have stated that the

catalyst funds have resulted in new and expanded

collaborative relationships among stakeholders,

within and external to academia. Awardees have

described how obtaining timely ethics approval to

complete the proposed project within a 12-month term was challenging, particularly when

collaborating with external colleagues. In some cases, project timelines were affected by new

equipment requirement/delays, modified/unsuitable commercial products, restricted access to

external datasets (impact on timelines and access for team members), or changes in career paths

(departure of team members). In some instances, investigators’ competing demands in teaching or

clinical environments made it difficult to get approval for necessary dedicated research or training

time. Teams that faced unanticipated delays made formal extension requests. Individual cases were

reviewed and where deemed appropriate, project extensions were granted. A summary of the

completed grants as well as related accomplishments and challenges is included below.

2015 Catalyst Grants

The role of CCN1 in Duchennes Muscular Dystrophy

Investigative team: Mahem Ahmed (trainee), Craig Campbell, Lisa Hoffman, Andrew Leask,

Victoria Turnbull (trainee)

Summary: Duchenne Muscular Dystrophy (DMD) is a debilitating disorder with no cure that

results in profound muscle weakness for 1 in 3300 boys. The CCN matricellular family of proteins

regulates a variety of cell functions including wound repair and angiogenesis that is associated

with the inflammatory response that leads to fibrosis in DMD patients. CCN1 is known to have a

role in the inflammatory response, but it remains uncharacterized in DMD. We hypothesized that


28

CCN1 is upregulated in response to increasing severity of fibroses. The team assessed this using

two different staining protocols (DAB and immunofluorescence) and three different disease

severity mouse models (1- the weakly affected mdx mouse that lacks dystrophin, 2- the mdx

utrn+/- mouse lacking one utrophin allele with intermediate disease severity, and 3- the severely

affected mdx utrn-/- mouse lacking two utrophin alleles) compared to wildtype controls. The study

revealed that using DAB, CCN1 was found to be significantly upregulated in severely fibrotic mdx

utrn-/- mice compared with less affected/non-fibrotic DMD genotypes and healthy wild-type

controls. When using fluorescence, moderately fibrotic mdx utrn+/- mice were found to have

upregulated CCN1 expression compared to wildtype controls and non-fibrotic DMD mice. As

such, this study supports a role for CCN1 being present in the course of fibrosis progression in

DMD. Impact: Further studies are underway to assess the potential of CCN1 as a biomarker of

fibrosis in this neuromuscular disorder. If identified as an optimal biomarker of fibrosis in DMD

patients, current partnership with Industry Partner, Akrivis Technologies LLC will be expanded to

develop an anti-CCN1 targeted therapy. The catalyst funds enabled the team to engage 2 trainees

and established one new academic collaboration. The team foresees submitting proposals to CIHR,

NSERC and possibly Heart & Stroke within the next 1-2 years. The results have been presented at

the Gordon Research Conference.

Autoantibodies in the Unaffected First-Degree Relatives of patients with Rheumatoid

Arthritis and Juvenile Inflammatory Arthritis

Investigative team: Nick Anand (trainee), Daniela Ardelean, Lillian Barra, Ewa Cairns

Summary: The purpose of this study was to investigate unaffected first-degree relatives (FDR) of

rheumatoid arthritis (RA) and juvenile inflammatory arthritis (JIA) as a model for the pre-disease

state of these autoimmune disorders. RA and JIA are diseases with unknown cause that lead to

joint pain, damage and functional impairment. Specifically, the team was focused for this project

on investigating the role of anti-citrullinated protein/peptide antigens (ACPA) and anti-

homocitrullinated protein/peptide antibodies (AHCPA) in this population. They found that

unaffected FDR of adult RA patients expressed IgG AHCPA more commonly than healthy

controls, but that other isotypes were infrequently expressed. Unlike ACPA, AHCPA were not

associated with joint pain, smoking, or a known genetic risk factor for RA (Bell DA, et al. 2017).

In preliminary experiments, sera from RA patients positive for both ACPA and AHCPA induced

joint swelling when injected into mice after citrullinated proteins were injected into the joints of

these mice. Histologic examination of the joints revealed synovial thickening and inflammatory

cell infiltration. Impact: Future Studies related to this work will include the prospective

monitoring FDR who were AHCPA-positive, without any evidence or symptoms of arthritis, to

determine whether they develop RA over time. Also, the team will continue to investigate whether

AHCPA is arthritogenic using mouse models. A donation from St. Joseph’s Health Care (SJHC)

Foundation will support the monitoring of unaffected FDR. Recruitment to this cohort is ongoing

without funding pending approval by the SJHC Foundation. Once additional pilot data is available,

the team intends to leverage support from other granting agencies for ongoing studies that involve

their novel animal model for RA.


29

Development and Validation of Patient-Specific 3D - Printed Bone Models with

Heterogeneous Bone Density Distributions for Implant Design and Surgical Evaluation

Investigative team: George Athwal, Louis Ferreira, Ashish Gupta (trainee), Nikolas Knowles

(trainee)

Summary: Synthetic (3D-printed) bones that are representative of

patients with various types of osteoarthritis are needed to address the

shortage of cadaveric joints available to researchers. This team set out to

develop synthetic shoulder joints that model the physical characteristics

of natural bones of arthritic patients using computed tomography (CT)

and modern 3D-printing methodologies. The goal was to develop an

alternative to cadaveric joints that would improve our ability to evaluate

current treatment options for painful joints, to advance our approach to

developing patient-specific joint implants, and to expand surgical skills

training opportunities. Ultimately, the vision was to enhance clinical outcomes following surgical

procedures. Impact: The team was successful in developing a micro-CT compatible uni-axial joint

loading device. They evaluated simulation software with a 100-fold decrease in computational

requirements for micro-level simulation of bone. Through this project, new collaborations were

formed with an academic investigator and trainee. The team continues their work with a focus on

improving understanding of the mechanical properties and computational models of the shoulder

for the purpose of enhancing implant designs and evaluation of surgical approaches. The funds

were leveraged to secure funding from the St. Joseph’s Foundation funding to purchase a custom-

designed CT-compatible robotic joint loading mechanism ($30,000). Results are available in two

successfully published article (Knowles NK, Reeves JM, Ferreira LM. Quantitative Computed

Tomography (QCT) derived Bone Mineral Density (BMD)

in finite element studies: a review of the literature. Journal

of Experimental Orthopaedics, 2016;3(1):36 and Reeves

JM, Knowles NK, F, Athwal GS, Johnson JA. Methods

for Post-Hoc Quantitative CT Bone Density: Phantom-

only and Regression. Journal of Biomechanical

Engineering - Accepted April 2018). Three additional

manuscripts are under development. Nine presentations

have been made at various conferences. Finally, a large

grant has been submitted to CIHR and then converted into

proposals to the St. Joseph’s Foundation and NSERC to

continue to build on this work.

Cerebrovascular Control in Osteoarthritis

Investigative team: Trevor Birmingham, Kevin Shoemaker, Baraa Al-Khazraji (trainee)

Summary: The human musculoskeletal and cardiovascular systems enable mobility,

independence, physical activity, and health. Yet, diseases of these systems create the greatest

healthcare burdens in Canada and globally. The most common of these diseases, osteoarthritis

(OA) and stroke, share several risk factors and comorbidities, but little is known about their shared

disease mechanisms. The team’s overall objective was to better understand cerebrovascular health


30

in patients with OA and, subsequently, address strategies for primary and secondary prevention.

They compared OA patients, healthy controls, and patients with cardiovascular disease (CVD) but

no OA, to: 1) quantify cerebrovascular reactivity to carbon dioxide and rapid transient reductions

in arterial pressure; 2) assess circulating markers of chronic inflammation and vascular

endothelium damage as well as flow-mediated dilation; and 3) measure polymorphonuclear

neutrophil (PMN) rolling/binding in cultured human cerebrovascular endothelial cells using an in

vitro bioassay with patient plasma. They found that patients with OA are at a higher risk of

developing cardiovascular and cerebrovascular disease, and vascular health parameters in those

with OA are similar to those with known CVD. Impact: The team plans to leverage the BJI catalyst

support to: a) increase the sample size and confirm cerebrovascular problems identified in the

current pilot, b) study underlying mechanisms of cerebrovascular and peripheral vascular

responses (e.g., inflammatory pathways), and c) develop an exercise prevention program to

improve cerebrovascular and peripheral vascular health outcomes. The results have been presented

at 3 conferences and 1 manuscript has been submitted for publication (results pending). A grant

proposal has been submitted to an external funding agency to support future studies (results

pending).

Generation of Patient-Specific Induced Pluripotent Stem Cells for Modeling Rheumatoid

and Juvenile Idiopathic Arthritis

Investigative team: Daniela Ardelean, Janet Pope, Ruxanda Rusu (trainee), Cheryle Séguin

Summary: With a focus on modeling arthritis in children and adults in the laboratory, this project

was well aligned with multiple Institute objectives and research areas. It prompted new

collaborations with two academic investigators, one academic collaborator, and one community

collaborator. The main outcomes of the study included: 1) the generation of multiple clones of

induced pluripotent stem cells

(iPSC) from four patients with

rheumatoid arthritis and one

control; 2) the identification of

novel potential gene

candidates for juvenile

idiopathic arthritis (JIA) in 2

related children with JIA; and

3) the testing of prediction

algorithms for variant analysis

in polygenic diseases such as

JIA. Impact: The team looks

forward to building on this

work to continue the

characterization of iPSC from

rheumatoid arthritis patients and to start the generation of iPSC in children with JIA as well as the

testing of novel gene candidates in other children with JIA. The BJI funds that supported this

project were leveraged to secure $3.5K from the Rare Diseases Foundation and a small laboratory

space. The team plans to submit 2 publications regarding novel genes candidates in JIA and iPSC

in RA and JIA. Results have been presented by the team trainee at regional and national

conferences.


31

Exploring the Proteinase Activated Receptor/TRPV4 signaling axis in Osteoarthritis

Investigative team: Peter Chidiac, Al Getgood, Rithwik Ramachandran

Summary: People with Osteoarthritis (OA) commonly experience pain and inflammation that

negatively impacts their lives. A better understanding of pathogenic factors is crucial to guiding

the development of new therapies that will not only manage symptoms, but also minimize

progression of disease. Proteinase activated receptors (PAR) are G protein coupled-receptors

(GPCRs) that are triggered following injury or infection. PARs stimulate cytokine production and

leukocyte recruitment to the site of injury resulting in inflammation. Early results suggest that PAR

activation sensitizes the mechanosensitive ion channel transient receptor potential vanilloid-4

(TRPV4), an important mechanosensor of the musculoskeletal system. Given that chondrocytes,

osteoblasts and osteoclasts (cartilage and bone cells) all appear to express TRPV4 and members

of the PAR

family, the team

aimed to

examine the role

of PAR

activation in the

regulation of

TRPV4.

Supported by

catalyst funds,

the team

developed: 1) a

highly sensitive biosensor for the detection of PAR activation by enzymes in biological fluids; 2)

a transgenic mouse model for tissue specific deletion of TRPV4; and 3) a transgenic mouse to

identify cellular location of TRPV4 expression. The team has also recruited knee OA patients to

the study and obtained joint fluid to identify the presence of PAR activating enzymes. Early results

have documented an abundance of PAR activating enzymes in the inflamed joint fluids and studies

linking this activity to TRPV4 sensitization is ongoing. Impact: Future studies will assess whether

mice with TRPV4 deletion in various musculoskeletal tissue are protected and whether activation

of PARs exaggerates OA damage in relation to PAR sensitization of TRPV4 function. A post-

doctoral fellow has been recruited to spearhead additional experiments needed prior to applying

for external funding. Publications describing the biosensor and the transgenic mice are under

development.


32


The table below provides a list of the 2016 catalyst grant and reporting timelines. We look

forward to featuring these projects in next year’s annual report.

Catalyst Grants Awarded in 2016

Teams Home Faculty Title Reports due

Athwal, George

Doherty, Chris

Faber, Ken

Grewal, Ruby

King, Graham

MacDermid, Joy*

Schulich

Schulich

Schulich

Schulich

Schulich

Health Sciences

Long-term healthcare consequences of upper

extremity fractures: A population perspective

March31, 2018

Beier, Frank

Diop, Mamadou*

Schulich

Engineering

Can joint blood flow be used to monitor

treatment response in rheumatoid arthritis?

August 30, 2018

Burkhart, Timothy*

Getgood, Alan

Engineering

Schulich

Optimizing surgical interventions to mitigate

the effects of post traumatic osteoarthritis

August 30, 2018

Dickey, Jim

Walton, David*

Health Sciences

Health Sciences

Development and implementation of a VR-

based simulator to evaluate the relative role of

mechanics and startle in clinical neck pain

mechanisms

August 30, 2018

Flynn, Lauren*

Seguin, Cheryle

Engineering/Schulich

Schulich

Development of tissue-specific instructive

matrices for intervertebral disc regeneration

March 31, 2018

Marsh, Jackie*

Petrella, Robert

Health Sciences

Schulich

Cost of implementation and patient resource

use associated with a community-based

targeted education and exercise program to

limit the burden of hip and knee osteoarthritis

(OA)

February 28,

2019

Price, Aaron*

Trejos, Ana Luisa

Walton, Dave

Engineering

Engineering

Health Sciences

Wearable Smart Polymer Stretch Sensors for

the Clinical Assessment of Patient Recovery

from Neck Injury

April 30, 2018

Rasoulinejad,

Parham*

Teeter, Matt

Schulich

Schulich

Design & Development of a novel stand-alone

lumbar fusion device

August 30, 2018

* nominated applicant/main contact person


We congratulate the 3 applicant teams that were awarded catalyst grants in 2017. Their proposals

were well thought out and innovative. The review committee noted that their projects were well

aligned to the core values of the Institute and met the required eligibility criteria (BJI members,

minimum of two applicants from distinct disciplines, potential for high impact on MSK health).

We look forward to learning about the success of these teams in 2019.



Appleton, Tom*

Beier, Frank

Lanting, Brent

Mrkobrada, Marko

Schulich

Schulich

Schulich

Schulich

The association of synovitis with patient

outcomes after total knee arthroplasty for end-

stage

March 31, 2019


33



Holdsworth, David

Lalone, Emily*

MacDermid, Joy

Suh, Nina

Schulich

Engineering

Health Sciences

Schulich

Effect of Distal Radius Fractures on Joint

Mechanics, Osteoarthritis and Patient

March 31, 2019

Rasoulinejad, Parham*

Teeter, Matt

Schulich

Schulich

Static and Fatigue Testing of a Novel Fusion

Construct for Atlantoaxial Instability

March 31, 2019

* nominated applicant/main contact person

2.4: Biennial BJI Research Retreat

The London Convention Centre was echoing with enthusiasm on

May 2, 2017 as researchers, consumers, private-sector partners, and

other key parties joined members of the Bone and Joint Institute for

a day of reflection and research development. With a vision of life-

long mobility, the group of over 100 participants came together to

build on recent successes in order to improve the lives of millions of

Canadians who suffer daily from bone and joint health issues.

Western’s Vice-President of Research, John Capone was thrilled to

be part of the day and excited about the ground-breaking approach

to research that the Bone and Joint Institute is enabling in London

stating that: “Most researchers are still solitary in their

view of what they do and most institutions are resistant

to the changes that are needed to foster and engage

multidisciplinary integrated research in the way that it

needs to be done,” says Capone. “The Bone and Joint

Institute is the epitome of how to carry out this type of

new research in a meaningful way. It’s actually the first

university designated Institute under our new guidelines

and policies and it has done a remarkable job so far.”

The retreat included multiple interactive sessions to

learn about and contribute to the work of Institute

members. “From the morning networking breakfast, to

project

overviews, to advancing skills and opportunities related

to knowledge translation, collaborative relationships,

engaging patients in research, and training the next

generation of researchers, the day was full of

opportunities to move our mandate forward,” said

Frank Beier, chair of the planning committee.

Retreat participants were thrilled with the inclusion of

various stakeholders and enjoyed the blend of

perspectives in panel discussion with researchers,

consumers, funders, and private-sector partners. Many


34

attendees expressed great interest in upcoming events

like the Canadian Bone and Joint Conference that will

be hosted by the Institute in the Spring of 2018. “This

type of organization has really fostered an approach

to research that is different, a way to make meaningful

advances that would have been impossible to do under

normal structural constraints that we all face. It is a

great model,” concluded Capone. “From my

perspective, the Bone and Joint Institute has shone a

light on the way that we need to operate to be

competitive and have a real impact on our

communities and in our world”.

2.5 Recruitment

In collaboration with partner Faculties, targeted strategic recruitments and timelines were set for

the first 5-years of Institute operations (2014 to 2019). With over 80 applications received to date

and 12 candidates interviewed, we have secured the recruitment for three planned positions – 2

Early Career Researcher (ECR) positions (Health Economics - Jacqueline Marsh start date of

July 2016 with the Faculty of Health Sciences; Orthopaedic Biomechanics - Ryan Willing start

date of July 2017 with the Faculty of Engineering– details provided in the 2016 annual report),

and 1 Western Research Chair (WRC) in Exercise, Mobility, and Health announced in November

2017: http://news.westernu.ca/2017/11/new-chair-looks-ease-pain-millions/ (see her bio below).

BJI also supported Faculties with relevant recruitments since 2015, including Emil Schemitsch

(Schulich School of Medicine & Dentistry), Joy MacDermid (Health Sciences), Tom Appleton

(Schulich School of Medicine & Dentistry), Emily Lalone (Engineering), Mikko Karttununen

(Science), Andrea Waters-Rist (Social Science), and Jay Stock (Social Science).

Michele Crites Battié has dedicated her career to studying common, symptomatic spinal disorders

and expanding our understanding of underlying pathologies and their progression and prognosis.

Such information is critical for improving diagnosis and informing the development of more

efficient and effective treatments. She is the first WRC to join the Bone and Joint Institute, and

has an appointment in the School of Physical Therapy that began in November of 2017. BJI

members look forward to incorporating Michele into crucial transdisciplinary projects that have

been anxiously awaiting someone with her knowledge and expertise. Her main areas of interest

are degenerative spinal conditions, such as disc degeneration and

lumbar spinal stenosis, and lower-back pain. She will continue her

longitudinal studies examining genetic influences, structural features

evaluated on imaging, and lifestyle and environmental factors on the

occurrence and progression of such conditions. Currently, the field

is plagued with inconsistencies in basic concepts, definitions and

measures, which have hindered progress. Michele plans to continue

spearheading work with the International Society of the Study of the

Lumbar Spine on broad adoption of consistent nomenclature and

core measures, particularly related to imaging phenotypes or case

definitions. This is sorely needed to improve interpretation of results

across studies to advance knowledge.

http://news.westernu.ca/2017/11/new-chair-looks-ease-pain-millions/


35

Currently open and/or upcoming positions include:

▪ ERC in Musculoskeletal Health: to advance the area of MSK imaging, biological or

biomedical aspects of bone and joint diseases (position posting coming in 2018-19)

▪ WRC in Musculoskeletal Mechatronics: to advance developments in image-guided

orthopaedic surgery, advanced rehabilitative and medical devices, and instrumented

implants (currently recruiting);

▪ WRC in MSK Health/Regenerative Medicine: to provide expertise and critical research

capacity in the area of regenerative medicine − bridging the gap between stem cell

researchers, tissue engineers, and clinician scientists (currently recruiting).

2.6: The Collaborative Training Program in MSK Health Research (CMHR)

A Western School of Graduate and Post-Doctoral Studies approved training program, CMHR had

its highest ever enrolment this year with a total of 89 trainees (6 undergraduate students, 40

master’s students, 31 doctorate students, 12 postdoctoral fellows). Since the first enrolment in

2015, over 20 trainees graduated from their home program (master’s and/or doctoral) with an “in

MSK Health Research” degree designation. A number of trainees, transferred directly into a

doctoral program, which extended their home program studies. Of the graduates, many continue

to work in academic or health-related fields. According to standard program lengths, we estimate

that approximately 20 trainees will complete their home programs with the MSK Health Research

designation in 2018, and nearly 30 the following year.

At its core, the program values and requires

enhanced trainee involvement in

transdisciplinary MSK research and community

outreach as a means of enhancing career

development and empowering the leaders of

tomorrow. This novel program will adopt a new

name in 2018 to adhere to changes in the

graduate studies structure: “The Collaborative

Specialization in Musculoskeletal Health

Research”. The new name will not alter the

program curriculum that integrates core cross-

disciplinary concepts associated with

59 62

89

0

20

40

60

80

100

2015 2016 2017

CMHR Enrolment Over Time

# of Trainees

6 7 6

2026

40

26

18

31

711 12

0

10

20

30

40

50

2015 2016 2017

CMHR Trainee Enrolment by Career Level Over Time

Undergraduate Master's Doctorate Postdoctoral Fellow


36

biomedical, engineering, clinical, and health services research in bone and joint health within all

of its activities (e.g. courses, learning modules, workshops, seminars, and retreats).

This year marked the start of the expanded partnership with the Ivey International Centre for Heath

Innovation. Case-focused workshops were delivered to trainees including: Introduction to

Pharmaceuticals and Medical Devices (April), Health Economics and Decision Logic (May),

Small and Medium Enterprises - Building the Case for Commercialization and Venture Capital

Investment (September), and Health Systems Structure and Trends (November).

The current pool of trainees is undoubtedly outstanding, as demonstrated by their success in

securing both internal and external funding (self-reported nearly 50 awards were secured by 33

trainees with NSERC, Arthritis Society, CIHR, OGS, WGRS grants totaling over $1.4 M in multi-

year funding) and in producing over 30 peer-reviewed MSK-related publications this year alone.

The quality and ambition of these students is also evident in their accomplishments related to

academic conferences. Multiple trainees attended and presented at national/international

conferences such as the American Academy of Orthopaedic Surgery Annual Meeting, American

Society for Bone and Mineral Research, Australia New Zealand Orthopedic Research Society &

Radiostereometric Analysis Network, Canadian

Connective Tissue Conference, Computer

Methods in Biomechanics and Biomedical

Engineering & Imaging and Visualization,

Design of Medical Device Conference in

Minneapolis, the Gordon Research Conference,

the International Cartilage Repair Society, the

International Society for Magnetic Resonance in

Medicine, 4th International Spine Research

Symposium (ORS PSRS Philadelphia), the

Orthopaedic Research Society, and the

Osteoarthritis Research Society International

World Congress.

Trainee Awards

Once enrolled in CMHR, trainees can apply to the competitive Transdisciplinary Bone and Joint

Training Awards program. The program can support the trainee and his/her research project.

Trainees under the supervision of a CMHR mentor (or a Faculty Member working in MSK

Research who intends to obtain CMHR mentor status) can also apply. The program includes two

award categories: 1) Up to $10,000/year for graduate students (Masters – maximum 2 years,

Doctoral – maximum 4 years), and 2) Up to $20,000/year for post-doctoral fellows or clinician-

scientists in training (maximum 2 years). Awards are adjudicated based on academic

achievements, the quality and novelty of the transdisciplinary research project, and the mentorship

and resources in the training environment. A clear relevance to MSK health and supervision by

BJI Faculty members from at least two distinct disciplines is mandatory. The 17 new awards

handed out to exceptional trainees this year bring our total number to 37 active awards.


37

Transdisciplinary Bone and Joint Training Awards 2017

New Transdisciplinary Training Awards

Trainee/Mentors Home Faculty Award Term Project Title

Docter, Shgufta (PhD)

Bryant, Dianne

Marsh, Jacquelyn

Physical Therapy

Schulich & Health Science

Health Science

09-2017 –

08-2018

“Cost effectiveness of an Alternative

Rehabilitation Care Pathway following

Total Knee Arthroplasty”

Fennema, Megan (MSc)

Teeter, Matthew

Lanting, Brent

Medical Biophysics, Schulich

Schulich

Schulich & Health Science

09/2016 –

08/2018

“Performance of sensor-based

measurements for evaluating joint

motion and function”

Hart, Harvi (PDF)

Birmingham, Trevor

Holdsworth, David

Physical Therapy, Health Science

Health Science

Schulich

09/2017 –

08/2019

“Gait retraining and foot orthoses for

patellofemoral osteoarthritis: Effects

on gait biomechanics, muscle

recruitment and 3D weight-bearing

imaging”

Hong, Greg (PhD)

Drangova, Maria

Holdsworth, David

Naudie, Douglas


Schulich

Schulich

Schulich

09/2017 –

08/2018

“Improving metal artifact reduction in

orthopedic MRI”

Kerr, Geoffrey (MSc)

Séguin, Cheryle

Holdsworth, David

Physiology & Pharmacology,

Schulich

Schulich

09/2017 –

08/2020

“Investigating pathways associated

with intervertebral disc degeneration”

Khan, Michaela (MSc)

Birmingham, Trevor

Willits, Kevin

Holdsworth, David


Health Science

Schulich

Schulich

09/2017 –

08/2019

“Weight-bearing and functional 3D

imaging of syndesmotic ankle sprains”

Liang, Yu-Ting (Natalie)

(MSc)

Gillies, Elizabeth

Flynn, Lauren

Chemistry, Science

Science & Engineering

Engineering & Schulich

09/2017 –

08/2019

“Synthetic-natural hybrid polymer

platform: towards cell delivery for the

treatment of MSK conditions”

Naghibosadat, Maedeh (MSc)

Hoffman, Lisa

Pathology, Schulich

Schulich

09/2017 –

08/2018

“Characterize and repair of the

vasculature in Duchenne muscular

dystrophy

Padmore, Clare (PhD)

Johnson, James

King, Graham

Biomedical Engineering

Engineering

Schulich

09/2017-

08/2018

“Carpal Kinematics and Intercarpal

Force Transmission in the Native and

Injured Wrist”

Schulz, Jenna (PhD)

Birmingham, Trevor

Beier, Frank

Shoemaker, Kevin

Health and Rehabilitation Sciences

Health Science

Schulich

Health Science

09/2017 –

08/2020

“Quantifying the relationship between

osteoarthritis and cerebrovascular

deficits”

Serack, Fiona (PhD)

Flynn, Lauren

Hess, David

Biomedical Engineering,

Engineering


Schulich

09/2017 –

08/2020

“Development of a cell delivery

strategy to modulate angiogenesis and

inflammation in mechanically-

dynamic soft connective tissues”

Sharma, Nadia (MSc)

Séguin, Cheryle

Flynn, Lauren


Engineering

Schulich


09/2017 –

08/2019

“Development of tissue-specific

instructive matrices for intervertebral

disc regeneration”

Tam, Clara (MSc)

Li, Shuo


Engineering

Schulich

09/2017 –

08/2019

“Using intelligent data analytics for

automated locomotor therapy planning

to improve mobility”

To, Bethia (MSc)

Beier, Frank

Appleton, Tom

Physiology and Pharmacology,

Schulich

Schulich & Health Sciences

09/2017 –

08/2019

“The role of nuclear receptor

peroxisome proliferator-activated

receptor delta (PPARdelta) in obesity-

associated OA”

Veras, Matthew (PhD)

Séguin, Cheryle

Bailey, Chris


Schulich

Schulich

01/2017 –

08/2020

“Investigating potential regulators of

ectopic calcification in a mouse model

of diffuse idiopathic skeletal

hyperostosis (DISH)”


38


New Transdisciplinary Training Awards

Trainee/Mentors Home Faculty Award Term Project Title

Webster, Jared (MSc)

Teeter, Matthew

Bryant, Dianne

Lanting, Brent

Kinesiology, Health Sciences

Schulich

Health Sciences

Schulich

01/2017-

08/2018

“The association between soft tissue

releases and bony resection performed

during total knee arthroplasty”

Zhou, Yue (PhD)

Trejos, Ana Luisa

Jenkins, Mary


Engineering

Engineering

Schulich

09/2017-

12/2019

“Assessment of Parkinsonian Hand

Tremor Development of a Tremor

Suppression Glove”


Continuing Transdisciplinary Training Awards

Trainee/Mentor Home Faculty Award Term Project Title

Atkinson, Hayden (PhD)

Birmingham, Trevor

Holdsworth, David


Health Science

Schulich

09/2016 -

08/2020

“A functional musculoskeletal stress

test for the knee: The MRI response of

articular cartilage to a challenging gait

knee-loading stimulus”

Baronette, Rudolphe (MSc)

Teeter, Matthew

Holdsworth, David

Birmingham, Trevor


Schulich

Schulich

Health Sciences

09/2015 –

08/2017

“Integrating fluoroscopy and gait

analysis in a virtual environment for

evaluating joint motion”

Farago, Emma (MSc)

Trejos, Ana Luisa

Dickey, Jim

Birmingham, Trevor

Electrical and Computer Engineering

Engineering

Health Science

Health Science

09/2016 –

08/2018

“Electromyography data analysis for

the identification of MSK injury”

Fournier, Dale (MSc)

Séguin, Cheryle

Holdsworth, David

Wilson, Tim

Anatomy & Cell Biology, Schulich

Schulich

Schulich

Schulich

09/2016 –

08/2018

“Radiographic and histological

characterization of pathological

mineralization of Diffuse Idiopathic

Skeletal Hyperostosis (DISH)”

Hijazi, Ayten (PDF)

Beier, Frank

Lanting, Brent


Schulich

Schulich

09/2016 –

06/2018

“The chromatin organizer CTCF in

skeletal health”

Hong, Gregory (MSc)

Drangova, Maria

Holdsworth, David

Naudie, Doug

Medical Biophysics

Schulich

Schulich

Schulich

09-2015-

08-2017

“Imaging near metal implants”

Kamoun, Hisham (MSc)

Flynn, Lauren

Naudie, Douglas

Mechanical & Materials Engineering


Schulich

09/2016 –

08/2018

“The role of macrophage phenotypes

in the remodelling of decellularized

adipose tissue”

Kerr, Geoffrey (MSc)

Séguin, Cheryle

Holdsworth, David


Schulich

Schulich

09/2015-

08-2017

“The effect of whole body vibration on

intervertebral disc and joint health in a

murine model”

Kim, Brandon (MSc)

Dixon, Jeffrey

Flynn, Lauren

Chidiac, Peter


Schulich


Schulich & Science

09/2016 –

08/2018

“Interaction of signaling pathways

controlling osteoblast activity”

Knowles, Nikolas (PhD)

Ferreira, Louis

Athwal, George


Engineering

Schulich

09/2015 –

08/2019

“The design of patient-specific glenoid

implants using a validated

computational model and an optimized

robot-assisted implantation technique”

Kornmuller, Anna (PhD)

Flynn, Lauren

Getgood, Alan



Schulich

09/2016 –

05/2020

“Naturally derived microcarriers as

tissue-specific 3-D cell culture

platforms”


39


Continuing Transdisciplinary Training Awards

Trainee/Mentor Home Faculty Award Term Project Title

Lorusso, Daniel (PhD)

Dixon, Jeffrey

Holdsworth, David


Schulich

Schulich

09/2015 –

08/2017

“Real-time microscopy during

dynamic mechanostimulation of live

cells”

Paish, Adam (PhD)

Holdsworth, David

Naudie, Douglas

Beier, Frank


Schulich

Schulich

Schulich

09/2015 –

08/2017

“The development of a 3D-printed-

metal functional hip implant system

for a small animal model of joint

replacement surgery”

Peidl, Alex (MSc)

Leask, Andrew

Pope, Janet


Schulich

Schulich

09/2016 –

08/2018

“CCN3: A novel anti-fibrotic therapy”

Pollock-Tahiri, Evan (PhD)

Hoffman, Lisa

Jackson, Dwayne


Schulich

Schulich

09/2016 –

03/2017

“Comprehensive analysis of

microvascular structure and function in

Duchenne Muscular Dystrophy”

Reeves, Jacob (PhD)

Johnson, James

Athwal, George



Surgery

09/2015-

08/2018

“Tools to Assess the Design of

Stemless Humeral Implants for

Shoulder Arthroplasty”

Serjeant, Meaghan (MSc)

Séguin, Cheryle

Bailey, Chris

Beier, Frank


Schulich

Schulich

Schulich

09/2016 –

04/2018

“Investigating the role of pannexin3 as

a regulator of intervertebral disc

health”

Shridhar, Arthi (PhD)

Flynn, Lauren

Gillies, Elizabeth

Chemical & Biochemical

Engineering


Science

09/2015 –

08/2018

“Design of an injectable adipose-

derived stem cell delivery platform for

tissue-specific musculoskeletal

regeneration”

Van de Kleut, Madeleine

(MSc)

Teeter, Matthew

Athwal, George


Schulich

Schulich

09/2016 –

08/2018

“Evaluation of implant fixation in

reverse total shoulder arthroplasty”

Veras, Matthew (MSc)

Séguin, Cheryle

Yeung, Ken


Schulich

Schulich

Schulich

01/2016-

08/2017

“An "Omics" approach to identify

potential regulators of eptopic

mineralization in mouse model of

DISH”

Summer Program:

The CMHR Summer Program aims to:

• promote student participation in MSK research;

• have students participate in lunch and learn

sessions offered throughout the program;

• have students present their results at a summer

research symposium;

• contribute to publications in peer-reviewed

journals; and

• encourage students to consider further careers in

MSK health research.


40

CMHR Summer Studentship Awards are open to all undergraduate students working on a MSK-

related project under the supervision of a member of the Bone and Joint Institute. A total of 18

students participated in the program and 6 were awarded a Studentship this year. They received a

maximum of $3000 from CMHR that was matched 50:50 by their supervisor or external sources

for a total of $6000 over 14 weeks.

CMHR Summer Studentship 2017 Awards

Trainee/Mentor Home Faculty Project Title

Sood, Arusha

Marsh, Jacquelyn

Lanting, Brent

Health Sciences

Health Sciences/Schulich

Health Sciences/Schulich

“Patient satisfaction and resource use after total knee

arthroplasty”

Yacoub, Daniel

Birmingham, Trevor

Health Sciences

Health Sciences

“Changes in gait biomechanics in response to a

functional knee-loading stimulus”

Sun, Emmy

O’Gorman, David

Schulich

Schulich

“The role of WT1 in the expression of fibrosis-

promoting genes in in vitro cell models”

Wong, Matthew

Walton, Dave

Dickey, James

Health Sciences

Health Sciences

Health Sciences

“Building an immersive virtual reality environment

for novel research applications in motor vehicle

collisions and other MSK trauma”

White, Ian

Seguin, Cheryle

Holdsworth, David

Beier, Frank

Dixon, Jeffrey

Schulich

Schulich

Schulich

Schulich

Schulich

“The effect of age on whole-body vibration-induced

joint degeneration”

Ioussoufovitch, Seva

Diop, Mamadou

Schulich

Schulich

“Assessing treatment response in rheumatoid arthritis

by monitoring joint blood flow

2.7: Research Funds

In 2017, Western University reporting indicated that BJI investigators held over 300 external

grants and over 200 internal grants (see table below). These totaled nearly $100 M in multi-year

funding, with nearly $85 M in external funds and over $14 M in internal funds (over $22 M in

2017 alone). This represents a growth of more than 150 grants and over $16 M held by BJI

members compared to 2016 (includes corrections to amounts reported in 2016). These data do not

include grants located at or shared with other institutions or Institutes and they are not limited to

projects that focus primarily on MSK. The graph below illustrates the amount of funds held since

the establishment of BJI.

Grant Type Number of

Grants Total Amount*

Average Amount **

Per Year *

External Salary 12 $12,700,000 $1,980,000

External Operating 246 $61,600,000 $13,910,000

External Infrastructure 39 $9,580,000 $2,640,000

External Training 21 $830,000 $410,000

External Grant Sub-Total 318 $84,710,000 $18,940,000

Internal Salary 8 $1,510,000 $190,000 Internal Operating 140 $11,710,000 $3,140,000

Internal Infrastructure 1 $110,000 $110,000

Internal Training 90 $1,250,000 $400,000

Internal Grant Sub-Total 231 $14,580,000 $3,840,000

TOTAL 549 $99,290,000 $22,780,000 * Rounded to nearest thousand $; ** Conservatively calculated by adjusting for fiscal disbursement and dividing the total amount of the grant by the number of years of the grant


41

56.6

71.4

84.7

8.8

15.1 14.6

0

10

20

30

40

50

60

70

80

90

2015 2016 2017

Mil

lio

ns

Overall Funding Held by BJI Investigators

External Grants Internal Grants

8

9.4

12

.7

41

.7

53

.9

61

.6

6.5 7

.7 9.6

0.4

0.4 0.81 1 1.5

7.1 8

.9

11

.7

0 0.1

0.10.6 0.9 1.3

0

10

20

30

40

50

60

70

2015 2016 2017

Mil

lio

ns

Multi-year Funding Held by BJI Investigators

External Salary Grants External Operating Grants

External Infrastructure Grants External Training Grants

Internal Salary Grants Internal Operating Grants

Internal Infrastructure Grants Internal Training Grants


42

Grants Supporting National Initiatives

CANADIAN MSK REHABILITATION RESEARCH NETWORK

This year marked the first full year of operations for the Canadian

MSK Rehabilitation Research Network, supported by a

$600,000 award from CIHR. This grant success would not have

been possible without the support of the Institute. A Network

Coordinator was hired in January who, along with two of the

Network’s five Principal Investigators based at Western

University, formed an Administrative Hub that works closely with

the Bone & Joint Institute. The first annual meeting was held in

conjunction with the 2017 Quebec Congress in Rehabilitation

Research, bringing a large percentage of the its nationwide

membership together for the first time. This event helped to

establish research priorities for the year.

The Network ran its first Pilot Grant Competition providing $90,000 in seed funding to

collaborative projects in MSK health research. The map below provides a graphical view of the

distribution of awards according to the home institution of the nominated team lead. The pilot

teams ranged from 5 to

13 team members.

Many teams included

members from different

jurisdictions.

Similarly, the Network

held a Trainee Awards

Competition, providing

financial assistance for

the purpose of fostering

the development of

future leaders in MSK

health (see map for

graphical distribution

of awards). In total,

over $150,000 in

funding was allocated

to these two initiatives.

Later in 2017, the

Network launched a

new website with

improved branding.

The goal was to attract external partnerships and better reflect the national presence of the Network

(www.mskrehabnet.com). Through the year, the Network increased its membership by 30% since

its inception. This expanded membership represents very broad involvement of multidisciplinary

researchers, collaborators, and partners from across Canada.

http://www.mskrehabnet.com/


43

CANADIAN NETWORK FOR MOBILITY RESEARCH

Dr. David Holdsworth, BJI Scientific Director,

made progress in establishing the “Canadian

Research Groups in MSK Health: A Self-

Assembled National Consortium”. Co-funded by

CIHR, BJI, and the McCaig Institute for Bone and

Joint Health, BJI organized a series of

teleconferences and a 2-day face-to-face meeting that brought together academic leaders from

across Canada (see map below). Core consumer, advocacy group, decision-maker, and funding

leaders were also included from the Patient Partners in Arthritis Program, AboutFace, Sjogren’s

Society of Canada, the Arthritis Society, Arthritis Alliance of Canada, and CIHR’s IMHA. The

goal of the meeting was to solidify relationships, foster new partnerships, increase awareness of

strengths, identify synergies, and recognize collaborative opportunities. Together the

representatives explored options to put together a national action plan to increase the profile of

MSK research in Canada. In addition, they discussed various mechanisms to improve their ability

to respond to cross-sectorial and jurisdictional funding opportunities as a unified group. With

consensus on a name – Canadian Network for Mobility Research (CaNMoR), slogan – “Active for

life! Muscle, bone and joint health research to keep Canadians moving”, and mission to “bring

researchers and partners together to generate solutions that will improve the health of Canadians,

through prevention and management of musculoskeletal conditions”, the group will start working

on short-term goals and priorities in 2018.


44

2.8: Knowledge Translation

A major focus of knowledge translation efforts in 2017 was to raise awareness, build capacity, and

engage key stakeholders in helping to shape the strategic direction of the Institute. By including

our members and partners in a series of strategic planning sessions, the leadership was successful

in obtaining multiple perspectives that will influence the setting of priorities and of the research

agenda for 2019 to 2024. Within the strategic planning process, approaches to facilitate and

establish mechanisms for the meaningful involvement of national and international partners,

private-sector representatives, and community members in the research itself were explored. Such

mechanisms will be crucial to advancing knowledge translation components related to the

development of meaningful products or tools, commercialization, the examination of clinical

practice, health behaviours, and social actions, as well as policy development/change.

Strategic Planning Process & Update

The strategic planning efforts started in the summer of

2017. A process was outlined and began in Oct 2017 with

a 2-day consultation workshop with over 30 BJI

representatives and partners. During this preliminary

working session, small groups rotated from one

brainstorming topic to the next, building on the work of the

group that came before them. Group work was analyzed

and summarized by facilitators and the full group

discussed until consensus was reached. The main topics of

discussion included the primary objectives of the

Institute, “big outside-the-box” ideas, strengths and

emerging strengths, challenges, visibility/knowledge

translation, international stature and relevance,

timelines and priorities, etc.

The results of this workshop were used to structure

the format and content of the full membership

consultation. Two drop-in sessions were made

available in 2 locations and an electronic version was

also provided as an alternative. Participants who joined

Photo 14 - Small group brainstorming at the October

strategic planning session

Photo 13 - Facilitated group strategic planning session in October to reach preliminary consensus on primary objectives, “big outside-the-box”

ideas, strengths and emerging strengths, challenges, and much more.

Photo 15 – Full membership drop-in strategic planning

sessions with walkthrough information and voting poster

stations regarding the future direction of BJI.


45

the session walked through a series of poster stations and used a voting system to indicate their

preferences regarding the future direction of BJI. They had the opportunity to provide additional

ideas/comments on open-station feedback boards, which other participants could, in turn, develop

further. The Strategic Planning Team was available during the session to answer questions and

receive suggestions. Finally, participants were invited to join a round-table discussion about the

station materials, should they be interested in learning more or providing additional information

in a different format.

In December of 2017, the Research and Business Advisory (RBAC) were asked to complete the

electronic version of the drop-in session and two post-session teleconferences were held to ensure

that their perspective was captured. The cumulative results were summarized in a draft plan and

shared with the Operations Committee (MOC). Once the MOC feedback was incorporate, the draft

was forwarded to the BJI Governing Board in preparation for a strategic planning meeting

scheduled for January 2018.

Strategic planning will continue in 2018 with more Board, RBAC, and MOC working meetings to

develop details about the approaches and metrics that relate to the priorities and objectives that

ranked high during the consultation process of 2017. During the fall of 2018, the draft strategic

plan will be provided to Reviewers as part of the Formal External Review of the Institute mandated

by the University. The goal is to finalize the Strategic Plan by December of 2018.

Photo 16 - Series of images captured during the full membership drop-in strategic planning sessions with voting poster stations, walkthrough

questionnaires, open feedback boards, strategic team consultations, and round table discussions.


46

Impacting Clinical Practice Guidelines – A BMJ Rapid Recommendation

In 2017, BMJ investigators published a Rapid

Recommendation (BMJ 2017;357:j1982) titled:

“Arthroscopic surgery for degenerative knee arthritis

and meniscal tears: a clinical practice guideline”.

BMJ’s Rapid Recommendations series takes direct

aim at influencing decision makers. This particular

paper recommended not using arthroscopy for knee

OA. It included recent evidence from a randomized

trail-based economic evaluation reported by BJI

members Marsh JD, Birmingham TB, Giffin JR, et al.

in their paper titled: “Cost-effectiveness analysis of

arthroscopic surgery compared with non-operative

management for osteoarthritis of the knee.” (BMJ Open2016;6:e009949. doi:10.1136/bmjopen-

2015-009949 pmid:26758265). The BMJ recommendation specifically referred to the BJI

members’ work stating that: “A rigorous economic analysis found that knee arthroscopy for

degenerative knee disease is not close to cost effective by traditional standards, even in extreme

scenarios that assume a benefit with arthroscopy.”

Illustrative Examples of Existing Partnerships

ARTHRITIS ALLIANCE OF CANADA MEMBERSHIP

BJI remains a proud member of the

Arthritis Alliance of Canada (AAC) to

support a central focus for national

arthritis-related initiatives. AAC is

dedicated to advocacy and raising

awareness of multiple audiences

(government, clinical, research, public)

about the models of care for inflammatory

arthritis and osteoarthritis and other

important initiatives. The organization

uses multiple mechanisms such as

regional advocacy teams, newsletters, hot

topic papers, and clinical tools for

providers and patients. BJI participated in

committees, meetings and events when

possible and sponsored the Knowledge

Translation Science/Research Award

again this year. Dr. Crystal MacKay (Department of Physical Therapy, University of Toronto) was

selected by AAC as the recipient of the award among a pool of 29 applications. Her project is

entitled “Using Knowledge Translation Theory to Inform the Development of Interventions to

Improve Management of Early Osteoarthritis”. More information on how to engage with AAC

can be found here: http://www.arthritisalliance.ca/en/.

http://www.arthritisalliance.ca/en/


47

ADDITIVE DESIGN IN SURGICAL SOLUTIONS (ADEISS) CENTRE

The Additive Design in Surgical Solutions (ADEISS) Centre is a for-

profit medical device manufacturing company based at Western

University’s Discovery Park. Its successful establishment is the

culmination of efforts from BJI Scientific Director David

Holdsworth, working in collaboration with the London Medical

Network and Renishaw Canada. This unique metal 3D printing

solution centre supports the development and fabrication of precise,

bio-compatible, 3D-printed medical devices. The goal of ADEISS

is to create a paradigm shift in the delivery of healthcare, which enhances the patient experience

by supplying personalized medical devices that better match patient needs and treatment

requirements. Since its opening in April 2017, ADEISS has been successful in obtaining its

Medical Device Establishment License with capabilities to manufacture and supply Class 1

medical devices. Within the first year of operations, the Centre has aided numerous BJI members

including researchers, orthopaedic surgeons, and dental clinicians with 3D printing of device

prototypes for active research and development projects. The ADEISS Centre is currently

positioning itself to secure ISO13485 accreditation and certifications in the United States, Canada

and Europe, such that it can be an approved supplier of 3D-printed medical and dental devices.

The company expects to have secured

the appropriate approvals to initiate

sales of its products and processes in

2019. Until approvals are in place for

human implants, there has been active

success in veterinary applications, such

as the implantation of a 3D-printing

“snout” that saved a Canadian family’s

7-year old Burmese Mountain dog who

had severe hard tissue loss due to a

tumour removal on its maxilla. http://www.renishaw.com/en/additive-manufacturing-in-

veterinary-surgery-saving-a-well-loved-member-of-the-family--42950

Exemplars of Sponsored Events and Community Outreach

▪ BERNIER DAY: The 10th Annual Suzanne

Bernier Memorial Lecture in Skeletal

Biology was held on May 1, 2017. Invited

speaker Dr. Lori A. Setton, PhD, Lucy and

Stanley Lopata Distinguished Professor of

Biomedical Engineering & Orthopaedic

Surgery at Washington University in St Louis

focuses her research effort on understanding

the mechanisms for degeneration and

regeneration of soft tissues of the

musculoskeletal system, including the

intervertebral disc, articular cartilage, and

meniscus. Her transdisciplinary research Photo 17 – The 2017 Suzanne Bernier Memorial Lecture special

guests and awardees.

http://www.renishaw.com/en/additive-manufacturing-in-veterinary-surgery-saving-a-well-loved-member-of-the-family--42950

http://www.renishaw.com/en/additive-manufacturing-in-veterinary-surgery-saving-a-well-loved-member-of-the-family--42950


48

program combines mechanical engineering, materials synthesis, and cell and molecular biology

to develop therapies for musculoskeletal pathologies. Her Bernier Lecture – “Engineering Drug

Depots to Target Local Inflammation” – generated great discussion among BJI members,

affiliates and partners. The annual Suzanne Bernier Memorial Award in Skeletal Biology

was given to CMHR trainee Margaret Sun for her work characterizing the role of nuclear

receptor proteins in cartilage development and disease. The BJI was pleased to partner with this

event, and hosted a reception following the lecture that brought together the BJI research

community.

▪ IMAGING NETWORK ONTARIO ANNUAL MEETING: The Imaging Network of Ontario (ImNO) was

held at the DoubleTree by Hilton in London, Ontario on March 15 & 16, 2017. Supported by

the BJI, this meeting promotes Canada’s role as a leader in medical imaging innovation. The

two-day symposium encourages discussions regarding new imaging programs and careers in

medical imaging. It serves as a forum where participants can share marketing and management

expertise. Multiple BJI members participated on the Scientific Committee and/or as abstract

reviewers and as session judges. The conference was attended by delegates from across Ontario

who participated in various component of the program that included 5 key note addresses, 62

oral presentations within 12 thematic sessions, and 113 posters. One of the sessions was entirely

focused on MSK Instrumentation and Quantitative Imaging, which was chaired by BJI member

Emily Lalone. Our BJI members delivered 8 podium presentations and over 45 posters during

the event that were authored by more than 15 BJI trainees and 25 BJI scientists.

▪ GORDON CONFERENCE: The BJI was a proud sponsor of the 5-day Gordon Research Conference

on Cartilage Biology and Pathology in April 2017, hosted in beautiful IL CIOCCO in Tuscany.

Co-chaired by BJI member Frank Beier and titled “Understanding Biology to Achieve Better

Cartilage Health”, the conference attracted almost 200 participants. Given the important role of

cartilage in bone growth and mobility, and presently limited treatment options for dysfunction,

the conference served an important role in expanding our understanding normal physiology and

pathophysiology of both growth plate cartilage and articular cartilage. The conference program

included 27 invited speakers, 16 short talks selected from abstract submissions, and 100 poster

presentations. Topics included recent findings from genetic and epigenetic mechanisms, as well

as metabolism and mechanical factors. The program was structured for the direct comparison

of advances in growth plate versus articular cartilage, and facilitated the translation of new

insights in cartilage biology to novel therapeutic approaches toward cartilage diseases.

▪ WALK FOR ARTHRITIS: This annual fundraising event

by the Arthritis Society takes place in cities across

Canada to raise awareness about arthritis and raise

funds to find a cure. BJI members participated in

large numbers in this event and hosted a “live lab”

where they presented and showcased some of their

work. This served as a mechanism to engage with

patients and local community members. It is a way

for researchers to share with the public the value of

their donations. At the same time, events like this one

help researchers gain invaluable insight into the

perspective of patients and their needs.


49

▪ THE ARTHRITIS SOCIETY TOUR OF BJI FACILITIES: In

collaboration with the Arthritis Society, key

stakeholders were welcomed for a tour of the HULC

(hand and upper limb clinic) Laboratories at St.

Joseph’s Hospital in October 2017. BJI members,

with different backgrounds and levels of experience,

informally presented their research and described the

value of investments made by the society (e.g. oral

presentations, science booths, and hallway

conversations). Members of the society and

community visited and interacted with researchers to

learn more about their work. They shared their

research questions and priorities from a consumer or

partner perspective.

▪ GRADUATE STUDENT LED PROGRAMS: BJI members participated in programs such as the Strong

Bones, Strong Minds, Strong Muscles Program to raise public awareness

https://www.schulich.uwo.ca/gradstudies/current_students/sbsmsm/index.html

▪ COMMUNITY PROGRAMS: BJI members devoted their time to programs like the Mini Medical

School a community lecture series focused on health topics and community relevant issues

https://www.schulich.uwo.ca/about/community_programs/mini_meds.html, the Partners in

Experiential Learning (co-op learning activities to enhance senior academic science, technology

and mathematics disciplines of Ontario’s school curriculum

https://www.schulich.uwo.ca/cartt/education/partners_in_experiential_learning/index.html),

March Break open houses (http://welcome.uwo.ca/march/), and Discovery Days in Health

Sciences (high school students and teachers explore careers in medicine and other health

sciences). Engineering has a number of outreach programs (https://www.eng.uwo.ca/outreach/)

including: Mechatronics Engineering Summer Academy (specifically for enriched Grades 9-12

high school students looking for a challenge over the summer months), Go Eng Girl (high

school girls learning about the world of engineering and career opportunities), Discovery

Western Fall Club, and Just for Girls Mentorship Program. Finally, members are engaged in

the London Regional Science Fair, the Canada Wide Science Fair, and many more events.

▪ CLINICAL WORKSHOPS such as those hosted by Fowler, HULC, the Centre for Activity and

Aging, and the Ortho Division were implemented to increase application of research knowledge

in clinical practice.

https://www.schulich.uwo.ca/gradstudies/current_students/sbsmsm/index.html

https://www.schulich.uwo.ca/about/community_programs/mini_meds.html

https://www.schulich.uwo.ca/cartt/education/partners_in_experiential_learning/index.html

http://welcome.uwo.ca/march/

https://www.eng.uwo.ca/outreach/


50

Technology Transfer and Commercialization

The information provided is this section is based on fiscal reporting by the technology transfer

office – WORLDiscoveries® at Western www.worldiscoveries.ca. It is important to note that

patent issuance can take between 6 to 10 years from the time of application. The total number of

technologies submitted by BJI members has doubled to 20 since the establishment of the Institute

for a total of 48 technologies to date since fiscal year 2015. Researchers can be listed as co-

inventors, meaning that there could be multiple inventors listed on a single application. The total

number of patent applications filed has fluctuated from 6 to 13 in the last three fiscal years. Since

fiscal year 2015, there has been a total of 31 patent applications. A total of sixteen patents have

been issued since 2015, 8 of which were in this most recent fiscal year. These data do not include

applications filled independently of WORLDiscoveries or via other Institutions.

Media and Communications

In 2017, both the Research and Business Advisory Committee and the Governing Board of the

Institute advised the Operations Committee to amplify efforts that increase the profile the Institute

and its members. The intent was to augment national and international awareness of the great work

happening at Western and generate opportunities for recruitment and collaboration. Therefore,

representatives of the BJI communication committee (ComC) began a series of action planning

meetings with Helen Connell (Associate Vice President), Keith Marnoch (Director of Media and

Community Relations) and other team members of Western’s Office of Communications and

Public Affairs. In addition, Western Communications representatives were engaged in the BJI

strategic planning process to expand their knowledge of and exposure to the Institute. This

facilitated the selection of priorities that needed to be incorporated in the Institute’s communication

action plan. To increase effective identification of stories that could be reported in the media (e.g.

upcoming events, research accomplishments and awards, and other initiatives), 3 actions were

identified: 1) attendance of a member of Western Communications at the monthly BJI member

showcase (http://boneandjoint.uwo.ca/events/bji_member_showcase.html); 2) quarterly thematic

meetings between the communication team and a small group of BJI members from different

disciplines; and 3) the addition of a Western Communications representative on the BJI ComC.

To support efforts aimed at increasing our brand recognition, Western Communications specified

the need to use Institute labels more consistently and ensure that the Institute gets listed as one of

the top affiliations by members when appropriate. As part of brand recognition and capacity

10 10

19

4

1

5

0

5

10

15

20

2015 2016 2017

Mil

lio

ns

Technology Transfer & Commercialization by BJI Investigators Over Time

Technology Submissions Patents Issued

http://www.worldiscoveries.ca/

http://boneandjoint.uwo.ca/events/bji_member_showcase.html


51

building, ComC members will work in collaboration with Western Communications to ensure that

BJI members have access to “Do’s and Don’t” materials regarding public speaking, media

interviews, and social media. Priority workshops for 2018 were identified: 1) Smart Social Media

- how researchers can get involved? What is the benefit? When to self-promote using personal

account versus when to use the university account and 2) Engaging with Media - building your

communications skills as an expert/champion contact. BJI will continue to liaise with Western

Communication to provide members the opportunity to serve as an expert/champion voice when

requested. Finally, in addition to timely news stories, a triad of BJI profile stories will be prepared

for February, March, and April to raise awareness prior to the Canadian Bone and Joint Conference

occurring in May 2018. This type of pre-planned stories will be organized around MSK events

through the year. Below is a list of member successes and accomplishments reported in 2017.

Member success & accomplishments reported in 2017

Date Title

December 2017 Important funding support for arthritis research in the Bone and Joint Institute (Drs.

Leask and Appleton)

http://boneandjoint.uwo.ca/news/docs/arthritis_funding_received.html

November 2017 Dr. Michele Crites Battié announced as BJI WRC in Exercise, Mobility, and Health

http://news.westernu.ca/2017/11/new-chair-looks-ease-pain-millions/ September 2017 Terry Peters named Member of the Royal Society of Canada

http://news.westernu.ca/2017/09/pair-named-royal-society-canada/

August 2017 Work keeps a ‘smart’ eye on glaucoma – Dr. Aaron Price

http://www.eng.uwo.ca/news/2017/work_keeps_a_smart_eye_on_glaucoma_.html

August 2017 Western University doctor endorses juvenile arthritis drug – Dr. Janet Pope

www.eng.uwo.ca/news/2017/work_keeps_a_smart_eye_on_glaucoma_.html

July 2017 St. Joe’s medical milestone marked – Roth|McFarlan Hand & Upper Limb Centre

https://www.ourlondon.ca/community-story/7449242-st-joe-s-medical-milestone-

marked/

July 2017 Dr. Joy MacDermid Leads the Canadian MSK Rehab Network

http://news.westernu.ca/2017/07/chair-challenge-easing-pain-millions/

June 2017 Dr. Louis Ferriera shares in $700,000 ORF Early Researcher Awards

http://news.westernu.ca/2017/06/young-researchers-get-boost-provincial-honour/

June 2017 Drs. Emil Schemitsch and George Athwal receive CORL grant and J. Edouard Samson

Award

https://www.schulich.uwo.ca/surgery/about_us/news/2017/index.html

May 2017 Advancements in Joint Repair – Dr. Alan Getgood http://www.rcinet.ca/en/2017/05/08/new-technology-into-joint-cartilage-repair/

May 2017 Knee key may be growing your own – Dr. Alan Getgood

http://news.westernu.ca/2017/05/knee-key-may-growing/

May 2017 BJI Trainees Awarded at 2017 Canadian Connective Tissue Conference

http://boneandjoint.uwo.ca/news/docs/CCTC2017.html

May 2017 Dr. Cheryle Seguin receives CIHR funding to move spine research forward (segment

starts at 0:56)

http://london.ctvnews.ca/video?clipId=1129106&binId=1.1137796&playlistPageNum=

1?t=56s

April 2017 Dr. Cheryle Seguin receives Award of Excellence – Leader

https://www.schulich.uwo.ca/about/news/2017/april/congratulations_to_the_2017_awar

ds_of_excellence_recipients.html

April 2017 Dr. Getgood and Dr. Litchfield explain new clinical trial at Fowler Kennedy Sport

Medicine Clinic

http://ctvnews.ca/video?clipId=1093254

April 2017 Western welcomes state of the art ADEISS facility to campus

https://www.youtube.com/watch?v=M9taD9YF3hw&t=2s&index=9&list=PLuxg9S70T

IQWUjLJsJJeqFJ6j3IZrtpEj

http://boneandjoint.uwo.ca/news/docs/arthritis_funding_received.html

http://news.westernu.ca/2017/11/new-chair-looks-ease-pain-millions/

http://news.westernu.ca/2017/09/pair-named-royal-society-canada/



https://www.ourlondon.ca/community-story/7449242-st-joe-s-medical-milestone-marked/

https://www.ourlondon.ca/community-story/7449242-st-joe-s-medical-milestone-marked/

http://news.westernu.ca/2017/07/chair-challenge-easing-pain-millions/

http://news.westernu.ca/2017/06/young-researchers-get-boost-provincial-honour/

https://www.schulich.uwo.ca/surgery/about_us/news/2017/index.html

http://www.rcinet.ca/en/2017/05/08/new-technology-into-joint-cartilage-repair/

http://news.westernu.ca/2017/05/knee-key-may-growing/

http://boneandjoint.uwo.ca/news/docs/CCTC2017.html

http://london.ctvnews.ca/video?clipId=1129106&binId=1.1137796&playlistPageNum=1?t=56s

http://london.ctvnews.ca/video?clipId=1129106&binId=1.1137796&playlistPageNum=1?t=56s

https://www.schulich.uwo.ca/about/news/2017/april/congratulations_to_the_2017_awards_of_excellence_recipients.html

https://www.schulich.uwo.ca/about/news/2017/april/congratulations_to_the_2017_awards_of_excellence_recipients.html

http://ctvnews.ca/video?clipId=1093254

https://www.youtube.com/watch?v=M9taD9YF3hw&t=2s&index=9&list=PLuxg9S70TIQWUjLJsJJeqFJ6j3IZrtpEj

https://www.youtube.com/watch?v=M9taD9YF3hw&t=2s&index=9&list=PLuxg9S70TIQWUjLJsJJeqFJ6j3IZrtpEj


52

Member success & accomplishments reported in 2017

Date Title

March 2017 London researchers enrol first Canadian patients in trial of tissue implant using patients’

own cartilage cells

http://mediarelations.uwo.ca/2017/03/31/london-researchers-enrol-first-canadian-

patients-trial-tissue-implant-using-patients-cartilage-cells/

March 2017 Drs. O’Gorman, Athwal, and Faber receive 2017 Charles S. Neer Award for Clinical

Science in the area of shoulder and elbow surgery

https://www.lawsonresearch.ca/news/lawson-researchers-win-neer-award

February 2017 Fellowship may unlock polymer research potential

https://news.westernu.ca/2017/02/fellowship-may-unlock-polymer-research-potential/

January 2017 Dr. David Holdsworth reappointed as the Dr. Sandy Kirkley Chair in MSK Research

http://www.schulich.uwo.ca/about/news/2017/january/announcement_dr_david_holdsw

orth_reappointed_as_the_dr_sandy_kirkley_chair_in_musculoskeletal_research.html

January 2017 Dr. James Johnson reappointed as the Graham King Research Chair

https://www.schulich.uwo.ca/surgery/about_us/news/2017/james_a_johnson_reappointe

d_as_graham_king_research_chair.html

http://mediarelations.uwo.ca/2017/03/31/london-researchers-enrol-first-canadian-patients-trial-tissue-implant-using-patients-cartilage-cells/

http://mediarelations.uwo.ca/2017/03/31/london-researchers-enrol-first-canadian-patients-trial-tissue-implant-using-patients-cartilage-cells/

https://www.lawsonresearch.ca/news/lawson-researchers-win-neer-award

https://news.westernu.ca/2017/02/fellowship-may-unlock-polymer-research-potential/

http://www.schulich.uwo.ca/about/news/2017/january/announcement_dr_david_holdsworth_reappointed_as_the_dr_sandy_kirkley_chair_in_musculoskeletal_research.html

http://www.schulich.uwo.ca/about/news/2017/january/announcement_dr_david_holdsworth_reappointed_as_the_dr_sandy_kirkley_chair_in_musculoskeletal_research.html

https://www.schulich.uwo.ca/surgery/about_us/news/2017/james_a_johnson_reappointed_as_graham_king_research_chair.html

https://www.schulich.uwo.ca/surgery/about_us/news/2017/james_a_johnson_reappointed_as_graham_king_research_chair.html


53

Section 3.0: Research Report

In 2017, BJI members published over 300

MSK-related papers, which are listed in

Appendix C. The expertise of BJI

members is often applied to other fields,

such as cardiovascular disease, respiratory

disease, and cancer, but these papers were

not included in the list herein.

Furthermore, duplicates were removed.

Since the goal of the Institute is to increase

collaborative work, a large portion of

publications include multiple members as

authors, but each paper was only counted

once in the sum.

The highlight and feature papers included in this section provide a small sample of the impressive

work being conducted within each of the primary objectives of the Institute:

1) understanding bone and joint diseases;

2) innovating in diagnosis and evaluation

3) developing and evaluating therapies; and

4) influencing key knowledge users.

The feature paper related to innovating in diagnosis and evaluation by Holmes et al. was selected

as the Best Clinical Science Paper in 2017 by the “American Shoulder and Elbow Surgeons”. In

the section related to developing and evaluating therapies, the 3 highlight papers demonstrate the

wide range of work being conducted from biomechanics in cadavers to clinical studies and

robotics. The studies in the influencing key knowledge users exemplify how research can directly

impact the end user in various settings

such as clinicians in medical centres, to

individuals in the work place, and

people the community.

To recognise collaborative and

transdisciplinary efforts, BJI Faculty

members are in BOLD font, BJI

trainees are underlined, and staff

members are italicized. Please see

section 2.1 for exemplars of

publications that have had notable

international contribution and impact

and demonstrate our international

collaborations.

0

50

100

150

200

250

300

350

2015 2016 2017

MSK-related Publications by BJI Members Over Time

# of Publications


54

3.1: Understanding Bone and Joint Diseases - 2017 Feature Publication

McCann, M. R., Yeung, C., Pest, M. A., Ratneswaran, A., Pollmann, S. I., Holdsworth, D. W., Beier, F., Dixon,

S.J., Seguin, C. A.

Whole-body vibration of mice induces articular cartilage degeneration with minimal

changes in subchondral bone.

Osteoarthritis and Cartilage, 25(5), 770-778. (2017) doi:10.1016/j.joca.2016.11.001

Objective: Low-amplitude, high-frequency whole-body vibration (WBV) has been adopted for the treatment of

musculoskeletal diseases including osteoarthritis (OA); however, there is limited knowledge of the direct effects of

vibration on joint tissues. Our recent studies revealed striking damage to the knee joint following exposure of mice to

WBV. The current study examined the effects of WBV on specific compartments of the murine tibiofemoral joint over

8 weeks, including microarchitecture of the tibia, to understand the mechanisms associated with WBV-induced joint

damage.

Design: Ten-week-old male CD-1 mice were exposed to WBV (45 Hz, 0.3 g peak acceleration; 30 min/day, 5

days/week) for 4 weeks, 8 weeks, or 4 weeks WBV followed by 4 weeks recovery. The knee joint was evaluated

histologically for tissue damage. Architecture of the subchondral bone plate, subchondral trabecular bone, primary

and secondary spongiosa of the tibia was assessed using micro-CT.

Results: Meniscal tears and focal articular cartilage damage were induced by WBV; the extent of damage increased

between 4 and 8-week exposures to WBV. WBV did not alter the subchondral bone plate, or trabecular bone of the

tibial spongiosa; however, a

transient increase was detected

in the subchondral trabecular

bone volume and density.

Conclusions: The lack of

WBV-induced changes in the

underlying subchondral bone

suggests that damage to the

articular cartilage may be

secondary to the meniscal injury

we detected. Our findings

underscore the need for further

studies to assess the safety of

WBV in the human population

to avoid long-term joint

damage.


55

Understanding Bone and Joint Diseases - 2017 Highlight Publications

Macintosh, A. A., Pinhasi, R., Stock, J. T.

Prehistoric women's

manual labor exceeded

that of athletes through

the first 5500 years of

farming in Central

Europe.

Summary: The intensification of agriculture is often associated with declining

mobility and bone strength. Because of the potential for sex-specific skeletal

responses to mechanical loading and a lack of modern comparative data, women’s

activity in prehistory remains difficult to interpret. This study compares humeral and

tibial cross-sectional rigidity, shape, and interlimb loading among prehistoric Central

European women agriculturalists and living European women of known behavior

(athletes and controls). Prehistoric female tibial rigidity at all time periods was highly

variable, but differed little from living sedentary women, and was lower than that of

living athletes. Humeral rigidity exceeded that of living athletes for the first ~5500

years of farming. Interlimb strength proportions among Neolithic, Bronze Age, and

Iron Age women were most similar to those of living semi-elite rowers. These results

suggest that rigorous manual labor was a more important component of prehistoric

women’s behavior than was terrestrial mobility.

Science Advances, 3(11), 12. (2017) doi:10.1126/sciadv.aao3893

Ratneswaran, A., Sun, M. M. G., Dupuis, H., Sawyez, C., Borradaile, N., Beier, F.

Summary: Currently, there are no treatments to alter osteoarthritis (OA) disease

progression, but targeting early changes in cellular behavior has great potential.

Nuclear receptors contribute to OA pathogenesis and could be viable therapeutic

targets, but their molecular mechanisms in cartilage are not understood. This study

examines global changes in gene expression and cellular lipid profile after treatment

of murine articular chondrocytes with agonists for four nuclear receptor implicated in

OA (LXR, PPARδ, PPARγ, and RXR). Differentially expressed targets were assessed

in control and cartilage-specific PPARδ knockout mice following surgical induction

of OA. This study shows that nuclear receptors regulate metabolic genes in

chondrocytes, specifically affecting triglyceride levels. PPARδ mediates regulation of

oxidative stress markers in chondrocytes. Collectively, these data suggest that nuclear

receptors are promising therapeutic targets for osteoarthritis.

Nuclear receptors

regulate lipid

metabolism and

oxidative stress

markers in

chondrocytes.

Journal of Molecular Medicine-Jmm, 95(4), 431-444. (2017) doi:10.1007/s00109-016-1501-5

Esseltine, J. L., Shao, Q., Brooks, C., Sampson, J., Betts, D. H., Séguin, C. A., Laird, D. W.

Connexin43 Mutant

Patient‐Derived

Induced Pluripotent

Stem Cells Exhibit

Altered Differentiation

Potential.

Summary: We present for the first time the generation of induced pluripotent stem

cells (iPSCs) from a patient with a connexin-linked disease. The importance of gap

junctions in bone homeostasis is exemplified by the autosomal dominant

developmental disorder oculodentodigital dysplasia (ODDD), linked to mutations in

the Cx43 gene. ODDD is characterized by craniofacial malformations, ophthalmic

deficits, enamel hypoplasia, and syndactyly. ODDD iPSCs exhibit reduced Cx43

mRNA and protein abundance and impaired channel function. Osteoblast

differentiation was delayed in ODDD iPSCs. Moreover, Cx43 subcellular localization

was altered during chondrogenic differentiation of ODDD iPSCs and this may have

contributed to the more compact cartilage pellet morphology found in differentiated

ODDD iPSCs. These studies highlight the importance of Cx43 expression and function

during osteoblast and chondrocyte differentiation.

Journal of Bone and Mineral Research, 32(6), 1368-1385. (2017) doi:10.1002/jbmr.3098


56

3.2: Innovating in Diagnosis and Evaluation - 2017 Feature Publication

Holmes, S., Diaz, A. M. P., Athwal, G. S., Faber, K. J., O'Gorman, D. B.

Neer Award 2017: A rapid method for detecting Propionibacterium acnes in surgical

biopsy specimens from the shoulder.

Note: The prestigious Charles Neer Award is presented annually in recognition of outstanding clinical investigation that

contribute to the understanding, care or prevention of injuries to the shoulder and elbow (http://www.ases-assn.org/?p=physic-

awards).

Journal of Shoulder and Elbow Surgery, 26(2), 179-185. (2017) doi:10.1016/j.jse.2016.10.001

Background: Propionibacterium (P) acnes infection of the shoulder

after arthroplasty is a common and serious complication. Current

detection methods for P acnes involve anaerobic cultures that require

prolonged incubation periods (typically 7-14 days). We have developed

a polymerase chain reaction (PCR)-restriction fragment length

polymorphism (RFLP) approach that sensitively and specifically

identifies P acnes in tissue specimens within a 24-hour period. Methods: Primers were designed to amplify a unique region of the 16S

rRNA gene in P acnes that contained a unique HaeIII restriction enzyme

site. PCR and RFLP analyses were optimized to detect P acnes DNA in

in vitro cultures and in

arthroscopic surgical

biopsy specimens from

patients with P acnes

infections.

Results: A 564 base-

pair PCR amplicon was

derived from all of the

known P acnes strains.

HaeIII digests of the amplicon yielded a restriction fragment pattern

that was unique to P acnes. P acnes-specific amplicons were detected

in as few as 10 bacterial cells and in clinical biopsy specimens of

infected shoulder tissues.

Conclusion: This PCR-RFLP assay combines the sensitivity of PCR

with the specificity of RFLP mapping to identify P acnes in surgical

isolates. The assay is robust and rapid, and a P acnes-positive tissue

specimen can be confirmed within 24 hours of sampling, facilitating

treatment decision making, targeted antibiotic therapy, and monitoring

to minimize implant failure and revision surgery.


57

Innovating in Diagnosis and Evaluation – 2017 Highlight Publications

Gagnon, S. S., Birmingham, T. B., Chesworth, B. M., Bryant, D., Werstine, M., Giffin, J. R.

Development of a

Clinician-Rated Drop

Vertical Jump Scale for

Patients Undergoing

Rehabilitation After

Anterior Cruciate

Ligament

Reconstruction: A Delphi

Approach.

Summary: Biomechanical parameters measured during a drop vertical jump task are

risk factors for anterior cruciate ligament (ACL) injury and are targeted during

rehabilitation after ACL reconstruction. A clinically feasible tool that quantifies

observed drop vertical jump performance would help inform treatment efforts. Using

a modified Delphi process, 20 of 31 invited experts (researchers and clinicians)

anonymously critiqued the content and scoring of a clinician-rated drop vertical jump

scale (DVJS). Three to five rounds were planned a priori, with a requirement of 75%

agreement on included items after the final round. Approx. 93% agreement was

achieved after the fourth round. Final items on the scale included the rating of knee

valgus collapse (no collapse to extreme collapse) and the presence of other

undesirable movements, including lateral trunk lean, insufficient knee flexion, and

limb-to-limb asymmetry. The beta version of the scale requires clinical testing.

Journal of Orthopaedic & Sports Physical Therapy, 47(8), 557-564. (2017) doi:10.2519/jospt.2017.7183

Micolini, C., Holness, F. B., Johnson, J. A., Price, A. D.

Summary: Load transfer through orthopaedic joint implants is poorly understood

and longer-term outcomes of these implants need further study. Monitoring

contact loads across the entire joint implant interface is necessary to clarify the

force transmission and distribution mechanisms exhibited by implants. This study

proposes and demonstrates the design, implementation, and characterization of a

3D-printed smart polymer sensor array using conductive polyaniline (PANI)

structures embedded within a polymeric parent phase. This specially developed

multi-material additive manufacturing process for PANI is shown to be an

attractive approach for the fabrication of implant components that have embedded

smart-polymer sensors. They could ultimately be employed for the measurement

and analysis of joint loads in orthopaedic implants for in vitro testing.

Assessment of Embedded

Conjugated Polymer Sensor

Arrays for Potential Load

Transmission Measurement

in Orthopaedic Implants.

Sensors, 17(12). (2017) doi:10.3390/s17122768

Somerville, L. E., Willits, K., Johnson, A. M., Litchfield, R., Lebel, M-E., Moro, J., Bryant, D.

Diagnostic Validity of

Patient-Reported History

for Shoulder Pathology.

Summary: This study aimed to determine whether patient-reported history items are

predictive of shoulder pathology and if they could be used to triage patients with

shoulder pathology to orthopaedic outpatient clinics. 178 patients reporting pain

and/or disability of the shoulder joint were prospectively recruited from two tertiary

orthopaedic clinics. Patients completed a questionnaire on the history of their

pathology, then a surgeon took a thorough history indicating the most likely

diagnosis and performed a physical examination. Diagnosis was determined through

arthroscopy or MRI arthrogram. The physical examination and history agreed in 75%

of cases. Of those that did not agree, the physical examination misdirected the

diagnosis in 47% of cases. History items were strong predictors of anterior and

posterior instability and subscapularis tears; thus, patient-reported history items

should be considered for use in a triaging instrument.

Surgery Journal-New York, 3(2), E79-E87. (2017) doi:10.1055/s-0037-1601878


58

3.3: Developing and Evaluating Therapies - 2017 Feature Publication

Abhari, R. E., Willing, R., King, G. J. W., Johnson, J. A.

An In Vitro Study of the Role of Implant Positioning on Ulnohumeral Articular Contact

in Distal Humeral Hemiarthroplasty.

Journal of Hand Surgery Am, 42(8), 602-609. (2017) doi:10.1016/j.jhsa.2017.03.034

Purpose: To investigate the effect of implant positioning on

ulnohumeral contact using patient-specific distal humeral (DH)

implants.

Methods: Seven reverse-engineered DH implants were manufactured

based on computed tomography scans of their osseous geometry. Native

ulnae were paired with corresponding native humeri and custom DH

implants in a loading apparatus. The ulna was set at 90 of flexion and

the humeral component (either native bone or reverse-engineered

implant) was positioned from 5 varus to 5 valgus in 2.5 increments

under a 100-N compressive load. Contact with the ulna was measured

with both the native distal humerus and the reverse-engineered DH

implant at all varus-valgus (VV) angles, using a joint casting method.

Contact patches were digitized and analyzed in 4 ulnar quadrants. Output

variables were contact area and contact pattern.

Results: Mean contact area of the native articulation was significantly

greater than with the distal humeral hemiarthroplasty (DHH) implants

across all VV positions. Within the native condition, contact area did not significantly change owing to VV angulation.

Within the DHH condition, contact area also did not significantly change owing to VV angulation. Conversely, in the

DHH condition, contact pattern did significantly change. Medial ulnar contact pattern was significantly affected by

VV angulation. Lateral ulnar contact was variably affected, but generally decreased as well.

Conclusions: Ulnar contact patterns were

changed as a result of VV implant

positioning using reverse engineered

DH implants, most notably on the

medial aspect of the joint. Implant

positioning plays a crucial role in

producing contact patterns more like

those observed in the native joint.

Clinical relevance: Recent clinical

evidence reports non-symmetrical

ulnar wear after DHH. This work

suggests that implant positioning is

likely a contributing factor and that

more exact implant positioning may

lead to better clinical outcomes.


59

Developing and Evaluating Therapies - 2017 Highlight Publications

Burkhart, T. A., Herman, B. V., Perry, K., Vandekerckhove, P-J., Howard, J., & Lanting, B.

Summary: Total knee arthroplasty (TKA) is an effective treatment for OA.

Restoration of physiologic varus alignment may restore the native soft tissue

tension and improve outcomes. Six paired fresh-frozen knee specimens were used

with left and right sides randomly getting either a physiologic alignment cut or a

standard of care neutral alignment bony cut prior to TKA. Loads of 100 and 200

N were applied at 0, 30, 60, and 90° of flexion and the magnitude of the medial

and lateral compartment distraction was measured. The loads were applied with

the knee specimen intact and post TKA. Performing a physiologic aligned TKA

resulted in medial-lateral soft tissue balance, but the flexion gap had greater

magnitude. Notably, a neutral aligned TKA was balanced, but found to recreate

intact knee flexion gaps. This suggests that coronal plane stability can be

achieved with physiologic alignment objectives, but potential for greater laxity.

Standard versus physiologic

bone preparation in total

knee arthroplasty and the

effect on joint space opening.

Clinical Biomechanics, 49, 155-161. (2017) doi:10.1016/j.clinbiomech.2017.09.009

Birmingham, T. B., Moyer, R., Leitch, K., Chesworth, B., Bryant, D., Willits, K., Litchfield, R., Fowler, P.J.,

Giffin, J. R.

Changes in biomechanical

risk factors for knee

osteoarthritis and their

association with 5-year

clinically important

improvement after limb

realignment surgery.

Summary: This prospective study assessed whether surgery-induced changes in

dynamic knee joint loading are associated with long term improvements in pain

and function after limb realignment surgery. Patient-reported outcomes, full-limb

standing radiographs, and 3D gait biomechanics were measured before, 6 months

after, and 5 years after medial opening wedge high tibial osteotomy (HTO) in 170

patients (46.4 ± 8.9 years, 135 males) with knee OA and varus alignment.

Substantial improvements in biomechanical risk factors for knee OA, and patient-

reported outcomes, were observed at 5 years. The change in knee joint loading

during walking observed with surgery was associated with achieving an increase

of ≥10 points in the Knee injury and Osteoarthritis Outcome Score at 5 years, with

and without adjusting for covariates. These results suggest the surgery-induced

change in the distribution of knee loads during walking is significantly associated

with long-term clinically important improvements in pain and function.

Osteoarthritis and Cartilage, 25(12), 1999-2006. (2017) doi:10.1016/j.joca.2017.08.017

Zhou, Y., Naish, M. D., Jenkins, M. E., & Trejos, A. L.

Summary: Traditional tremor management treatments have varying

effectiveness and carry significant risks and side effects. Here we describe the

design, modeling, implementation and characterization of a novel multi-channel

mechatronic splitter (MMS) for use in wearable devices that could be a promising

treatment option. The MMS allows a single drive motor to support multiple

independent outputs. It is controlled by a 2 W DC motor that could prolong device

operating life. At 129 g with maximum output speed of 120 rpm, and maximum

continuous torque of 0.15 Nm the MMS can be scaled for optimal performance.

The MMS suppressed tremor motion while following the voluntary movement of

7 individuals with Parkinson’s disease. An average of 12.4% RMS error in

voluntary motion tracking was achieved on a dynamic tremor suppression test.

Design and validation of a

novel mechatronic

transmission system for a

wearable tremor

suppression device.

Robotics and Autonomous Systems, 91, 38-48. (2017) doi:10.1016/j.robot.2016.12.009


60

3.4: Influencing Key Knowledge Users - 2017 Feature Publication

Raman, J., Walton, D., MacDermid, J. C., Athwal, G. S.

Predictors of outcomes after rotator cuff repair-A meta-analysis.

Journal of Hand Therapy, 30(3), 276-292. (2017) doi:10.1016/j.jht.2016.11.002

Introduction: Clinical outcomes associated with

rotator cuff repair (RCR) are generally favorable, but

no study has attempted to establish a set of predictors

that affect outcomes.

Purpose of Study: This study aims to statistically

analyze articles and establish a set of predictors that

affect outcomes after RCR.

Methods: An electronic literature search of multiple

databases was conducted to identify studies that

addressed prognosis after RCR. Quality ratings were

conducted with a prognostic study evaluation tool.

Summary data for predictors and outcomes were

extracted, entered in comprehensive meta-analysis

software, transformed where necessary, and pooled

to allow for estimation of odds ratio for each

predictor.

Results: From 18 studies, 3 were high quality, 7 were

moderate and 8 were low-quality studies. Fatty infiltration had a significant negative effect (OR ¼ 9.3), whereas larger

tear size, lower preoperative muscle strength (OR ¼ 4.0), multiple tendon involvement (OR ¼ 6.0), diabetes, and

worker’s compensation status (OR ¼ 8.7) had a moderate negative effect on outcomes after RCR. Older age had a

modest negative effect on cuff integrity at follow-up (OR

¼ 2.8), but no significant effect on function. In addition,

a history of trauma, smoking, and duration of

symptoms before surgery had no significant effect on

outcomes.

Discussion: Injury to the cuff (body structure),

physical impairment, personal factors and social

factors affects outcomes; although the importance of

predictors varies between anatomic and functional

outcomes.

Conclusions: A multifactorial biopsychosocial

prognosis should be considered in management. Level

of Evidence: Level 2.


61

Influencing Key Knowledge Users - 2017 Highlight Publications

Hanna, S. A., McCalden, R. W., Somerville, L., Howard, J. L., Naudie, D. D., MacDonald, S. J.

Morbid Obesity Is a

Significant Risk of Failure

Following Revision Total

Hip Arthroplasty.

Summary: Morbidly obese patients experience good outcomes following primary

total hip arthroplasty (THA); but, it is unclear if this applies to revision surgery.

This study examined the effect of a high body mass index (BMI) on the outcome

of revision THA. Group B included 56 patients with a BMI >40 kg/m2 and mean

age, BMI, and follow-up of 66.4 years, 45.7 kg/m2, and 11.7 years, respectively.

This group was matched by Group A patients with a BMI between 30 and 40 kg/m2

according to age, gender, and date of index procedure. Group B had a significantly

increased risk of revision surgery. Cumulative implant survival was 85% in Group

A and 69% in Group B at 15 years. HHS increased significantly following surgery

in both groups; however, HHS at last follow-up was significantly higher in Group

A. Morbid obesity appears to be associated with an increased risk of failure and

lower functional scores following revision THA.

Journal of Arthroplasty, 32(10), 3098-3101. (2017) doi:10.1016/j.arth.2017.05.014

Ji, X., Eger, T. R., Dickey, J. P.

Summary: Seats and cushions can attenuate whole-body vibration (WBV)

exposures and minimize health risks for heavy machine operators. We successfully

developed neural network (NN) algorithms to identify the vibration attenuation

properties for four different seating conditions and implemented each model to

predict the equivalent daily exposure values for various forestry and mining

vehicles. We observed that the new prototype No-Jolt™ air-inflated cushion

significantly improved the vibration attenuation properties of the seat that

initially had good performance, but not for the seat that had relatively poor vibration

attenuation properties. Also, operator’s anthropometrics and sex influenced the

performance of the cushion when the vibration environment included jolt exposures.

Evaluation of the

vibration attenuation

properties of an air-

inflated cushion with two

different heavy

machinery seats in multi-

axis vibration

environments including

jolts.

Applied Ergonomics, 59, 293-301. (2017) doi:https://doi.org/10.1016/j.apergo.2016.06.011

Kloseck, M., Fitzsimmons, D. A., Speechley, M., Savundranayagam, M. Y., Crilly, R. G.

Improving the diagnosis

and treatment of

osteoporosis using a

senior-friendly peer-led

community education and

mentoring model: a

randomized controlled

trial.

Summary: A randomised control trial was conducted to assess the knowledge and

outcomes of 105 participating seniors (mean age =80.5±6.9; 89% female) at

baseline and 6 months-post (intervention group n=53; control group n=52) the

implementation of a peer-led community education and mentorship program aimed

at improving the diagnosis and management of osteoporosis. There was no

significant change in knowledge of osteoporosis and no difference in knowledge

change between the two groups (mean difference =1.3, 95% confidence interval

[CI] of difference -0.76 to 3.36), but more participants in the intervention group

achieved a successful outcome (odds ratio 0.16, 95% CI 0.06–0.42, P,0.001). The

results suggest that this peer-led education and mentorship program can promote

positive health behavior in seniors and that it was effective for improving

osteoporosis risk assessment, diagnosis, and treatment in a community setting.

Clinical Interventions in Aging, 12, 823-833. (2017) doi:10.2147/CIA.S130573


62

Section 4: Financial Report

This section of the report uses a fiscal year format to match financial reporting (Year 1: May 1,

2014 to April 30, 2015; Year 2: 2015-16; Year 3: 2016-17; Year 4: 2017-18; Year 5: 2018-19).

In 2017, funding of Institute operation was derived from a number of sources with the majority of

our original partners confirming support for Year 4. This ongoing commitment is crucial to the

original senate approved 5-year budget plan and preparation for the next 5 to 10 years.

Current Institute and Cluster combined surplus of approximately $425 K (i.e. back flow of funds

in Year 1 and carry-over from previous programs) is being strategically allocated to enhance

Institute and Cluster activities and to sustain them beyond Year 5 (see projections in section 4.2).

Until the end of Year 5, there is no budgetary overlap between the Institute and Cluster. The $5 M

in Cluster funds is being administered by the Institute, in adherence with the senate-approved

budget (support of 3 Faculty ERC positions: salaries and benefits – limited term appointments,

administrative staff, training program/stipend support, outreach, and scholarly activities) (see table

in section 4.1). After Year 5 (2018-19), Cluster operations and activities will be the responsibility

of the Institute and the ERC positions become the responsibility of the landing Faculties. To bridge

the financial transition and burden, Catalyst Grants and Transdisciplinary Bone and Joint Training

Awards, as well as the position for the Manager of Research and Innovation, budgeted in Year 1

(not spent due to recruitment delays and alignment with the academic calendar) have been

reallocated to Year 6. It is important to note that the “Faculty Compensation and Startup” were

also delayed and those funds are committed in Year 6 and 7.

To sustain Institute and Cluster activities beyond Year 5, sustainability strategies must be put in

place to increase revenues. In the original Institute proposal, four main sustainability strategies

were identified: 1) community engagement and fundraising, 2) distribution of research overhead,

3) technology transfer/portion of revenues, and 4) external funding. The EXEC has and will

continue to work closely with the BOG and RBAC to plan and implement sustainability activities.

Activities undertaken in 2017 include:

1) Fundraising case development with the Vice-President (external) and her team - The

preliminary case notes were discussed at the annual BOG meeting in 2017. The need for

an updated strategic plan was identified and executed by the BJI team. With a draft strategic

plan in hand, the fundraising team is consulting with key stakeholders about the fundraising

case. A revised version of the case will be presented to BOG in June 2018.

2) External funding continues to be a focus as we support our members to come together and

build relationships with partners and submit proposals for major funding such as ORF, CFI

and NCE.

We look to the future and envision the Institute as an integral and standard component of the

University. Dedicated long-term partners, committed to various levels of support will be crucial to

the sustainability of the Institute and ongoing world-class achievement in the area of MSK health

at Western.


63

4.1: Cluster Financial Overview

Western Fiscal Year Year 1 Year 2 Year 3 Year 4 Year 5

2014-15 2015-16 2016-17 2017-18 2018-19

Actual Actual Actual Actual Projected

Beginning Balance

Cluster funds

(budgeted & annual carry fwd) 671,700 911,353 1,066,735 1,366,875 1,182,911

Cluster Expenses

Faculty Compensation 0 0 126,999 190,529 393,381

Faculty Start-up Funds 0 0 70,000 144,000 0

Catalyst Grants Program 0 128,714 164,569 198,289 160,000

CMHR Training Program 0 256,052 250,708 335,858 369,000

Staff Compensation (Manager of Research &

Innovation, CMHR Administrative Support) 17,907 77,491 152,259 166,770 170,949

Outreach & Scholarly Activities (Guest

Speakers, Meetings, External Event Support, Partner Awards) 0 22,112 33,719 45,676 67,000

Operating (Supplies, Printing, Equipment) 0 3,619 9,953 537 2,000

Sub-total (expenses) 17,907 487,988 808,207 1,081,659 1,162,330

Balance 653,793 423,365 258,528 285,216 20,581


64

4.2: Institute Financial Overview

Western Fiscal Year Year 1 Year 2 Year 3 Year 4 Year 5 Year 6

2014-15 2015-16 2016-17 2017-18 2018-19 2019-20

Actual Actual Actual Actual Projected Projected

Revenues

Past Program Funds (IDI, CIHR & carry fwd) 40,478 118,458 212,210 136,944 134,621 90,704

Cluster Funds *1,531,542

Membership Fees 0 3,280 4,350 2,425 4,500 4,500

Central Support 0 20,000 20,000 40,000 40,000 undetermined

Faculty Support 50,000 70,000 70,000 65,000 65,000 undetermined

Partner Support 30,000 30,000 20,000 20,000 20,000 undetermined

Conference Fees 0 11,792 0 0 0 0

Events Sponsorship 35,000 0 0 9,250 2,000 0

Sub-total (revenues) 155,478 253,530 326,560 273,619 266,121 1,626,746

Cluster Expenses

Staff Compensation (Mngr of Research &

Innovation & CMHR Admin Support) - - - - -

176,681

Faculty Compensation - - - - - *405,183

Catalyst Grant Program - - - - - 160,000

CMHR Training Program - - - - - 300,000

Institute Expenses

Staff Compensation (Manager of Operations and Casual Staff Hires)

22,843 54,557 148,272 90,856 93,165 105,193

Member Initiatives & Events (Seminars,

Workshops, Networking, National Conference and Research Retreat, Trainee Travel Awards)

4,979 22,946 32,812 27,083 51,250 41,000

Communications (Website Maintenance, Videos,

Advertisements, Annual Report) 1,433 632 1,592 1,923 10,000 10,000

Operating (Supplies, Printing, Equipment) 10,330 12,203 16,399 7,463 10,000 18,750

Outreach & Scholarly Activities (Speakers,

Meetings, External Event Support, Partner Awards) 0 0 750 11,673 10,000 23,250

Sub-total (expenses) 39,595 90,338 199,825 138,998 174,415 1,240,057

Balance 115,883 163,192 126,735 139,835 90,704 386,689

*Faculty Compensation committed in Year 6 and 7 (recruitment delays)


65

Section 5.0: Summary

In 2017,

▪ The BJI membership grew from 185 people to 254 to include 108 faculty, 89 CMHR

trainees, 18 other trainees, and 39 partner/collaborator/staff members.

▪ New awards added to the high number of widely recognized BJI researchers, including 14

Research Chairs (6 of which are Endowed/Industry supported), 2 Royal Society of Canada

Fellows, 3 Canadian Academy of Health Sciences Fellows, 1 NSERC E.W.R. Steacie

Memorial Fellowship, 10 New Investigator or Early Researcher Awardees, 3 Western

Distinguished University Professors, and 3 current Western Faculty Scholars.

▪ The Trainee Leadership Committee was launched with the aim of empowering trainees to

develop and implement outreach activities, contribute to BJI led initiatives, and help shape

the programming and opportunities provided through the CMHR.

▪ The BJI hosted its first Young Investigator Forum - organized by trainees for trainees on

Preclinical MSK Health Research. This event attracted over 60 participants from London,

Guelph, and Toronto. Building on this success, trainees spearheaded an application to

CIHR and were awarded funding to host the larger Canada-wide Bone and Joint Young

Investigator Forum in conjunction with the 2018 Canadian Bone and Joint Conference.

▪ The BJI Communications Committee refined its mandate and expanded its membership to

include colleagues from the University Communication and Public Affairs team.

▪ BJI and the Faculty of Health Sciences recruited the Western Research Chair (WRC) in

Exercise, Mobility, and Health, Dr. Michele Crites Battié.

▪ The BJI Catalyst Grant Program continued to promote transdisciplinary collaborative

teams and supported early stage high-impact research. New external grants have been

directly linked to this BJI program.

▪ The British Medical Journal cited a BJI study by Marsh et al. in a Rapid Recommendation

strongly discouraging the use of arthroscopic surgery for degenerative knee conditions,

adding the ‘rigorous economic analysis’ as further evidence that current practices and

policies should change.

▪ BJI members published over 300 MSK-related studies investigating a broad range of MSK-

related topics.

▪ The BJI initiated a robust strategic planning process to obtain multiple perspectives from

various audiences to identify and refine priorities and research agenda for the Institute as

it approaches its next 5-year cycle (2019-2024).


66

Appendices

Appendix A – BJI Faculty Membership List

BJI Faculty Member Member Status Faculty BJI Research Themes

1 Appleton Tom BJI Scientist Schulich School of Medicine & Dentistry


Clinical & health services

Basic biological & biomedical

2 Athwal George BJI Scientist Schulich School of Medicine & Dentistry Clinical & health services

3 Bailey Chris BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services


4 Barra Lillian BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical


5 Battié Michele BJI Scientist Faculty of Health Sciences Basic biological & biomedical

Population & community health

6 Beier Frank BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical

7 Birmingham Trevor BJI Scientist Faculty of Health Sciences Clinical & health services

8 Bryant Dianne BJI Scientist Faculty of Health Sciences

Schulich School of Medicine & Dentistry



9 Burkhart Timothy BJI Scientist Faculty of Engineering



Physical sciences & engineering


10 Cairns Ewa BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical

11 Chesworth Bert BJI Scientist Faculty of Health Sciences



12 Chidiac Peter BJI Scientist Schulich School of Medicine & Dentistry

Faculty of Science


13 Chronik Blaine BJI Scientist Faculty of Science Physical sciences & engineering

14 Connelly Denise BJI Affiliate Faculty of Health Sciences Clinical & health services

15 Degen Ryan BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services

16 Demirkaya Erkan BJI Affiliate Schulich School of Medicine & Dentistry Basic biological & biomedical


17 Dickey James BJI Scientist Faculty of Health Sciences Basic biological & biomedical


18 Diop Mamadou BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical


19 Dixon Jeffrey BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical


67


20 Doherty Tim BJI Scientist Schulich School of Medicine & Dentistry Clinical & health services

21 Drangova Maria BJI Scientist Schulich School of Medicine & Dentistry

Faculty of Science



22 Duggal Neil BJI Affiliate Schulich School of Medicine & Dentistry Basic biological & biomedical


23 El-Warrak Alexander BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical


24 Faber Ken BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical



25 Ferreira Louis BJI Scientist Faculty of Engineering




26 Fischer Lisa BJI Affiliate Faculty of Health Sciences Clinical & health services

27 Flynn Lauren BJI Scientist Faculty of Engineering




28 Frisbee Jefferson BJI Affiliate Schulich School of Medicine & Dentistry Basic biological & biomedical

29 Gan Bing Siang BJI Affiliate Schulich School of Medicine & Dentistry Basic biological & biomedical


30 Getgood Alan BJI Scientist Schulich School of Medicine & Dentistry Clinical & health services

31 Giffin Robert BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services

32 Gillies Elizabeth BJI Scientist Faculty of Engineering Faculty of Science Physical sciences & engineering

33 Gilliland Jason BJI Affiliate Faculty of Social Science




34 Goela Aashish BJI Affiliate Schulich School of Medicine & Dentistry

35 Goldberg Harvey BJI Affiliate Schulich School of Medicine & Dentistry Basic biological & biomedical

36 Grewal Ruby BJI Scientist Schulich School of Medicine & Dentistry Clinical & health services

37 Grohe Bernd BJI Affiliate Faculty of Engineering


Faculty of Science


38 Gwadry-Sridhar Femida BJI Affiliate Faculty of Science Clinical & health services

39 Hamilton Douglas BJI Affiliate Schulich School of Medicine & Dentistry Basic biological & biomedical

40 Hess David BJI Affiliate Schulich School of Medicine & Dentistry Basic biological & biomedical

41 Hoffman Lisa BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical

42 Holdsworth David BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical

43 Hosein Yara Kareen BJI Scientist Schulich School of Medicine & Dentistry Physical sciences & engineering

44 Hunter Susan BJI Affiliate Faculty of Health Sciences Clinical & health services


68


45 Jackson Dwayne BJI Affiliate Schulich School of Medicine & Dentistry Basic biological & biomedical


46 Jenkins Mary BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services

47 Jenkyn Thomas BJI Scientist Faculty of Engineering



48 Johnson James BJI Scientist Faculty of Engineering



49 Karttunen Mikko BJI Affiliate Faculty of Science Basic biological & biomedical


50 Kelly Gregory BJI Affiliate Faculty of Science Basic biological & biomedical

51 King Graham BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical

52 Kloseck Marita BJI Scientist Faculty of Health Sciences




53 Knopf George BJI Affiliate Faculty of Engineering Physical sciences & engineering

54 Lagugné-

Labarthe

François BJI Scientist Faculty of Science Physical sciences & engineering

55 Laird Dale BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical

56 Lalone Emily BJI Scientist Faculty of Engineering




57 Lanting Brent BJI Scientist Faculty of Health Sciences





58 Lawendy Abdel BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services

59 Leask Andrew BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical

60 LeBel Marie-Eve BJI Affiliate Schulich School of Medicine & Dentistry Basic biological & biomedical



61 Lemon Peter BJI Affiliate Faculty of Health Sciences Basic biological & biomedical


62 Lepore Natasha BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services

63 Li Shuo BJI Affiliate Schulich School of Medicine & Dentistry Physical sciences & engineering


64 Litchfield Robert BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services

65 MacDermid Joy BJI Scientist Faculty of Health Sciences




66 MacDonald Steven BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services

67 MacLeod Mark BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services


69


68 Marsh Greg BJI Affiliate Faculty of Health Sciences



69 Marsh Jacquelyn BJI Scientist Faculty of Health Sciences Clinical & health services


70 Matic Damir BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services

71 McCalden Richard BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services

72 Mittler Silvia BJI Affiliate Faculty of Engineering


Faculty of Science



73 Naish Michael BJI Affiliate Faculty of Engineering Physical sciences & engineering

74 Naudie Douglas BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services

75 Nelson Andrew BJI Scientist Faculty of Social Science

Faculty of Science




76 O'Gorman David BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical

77 Orchard Carole BJI Scientist Faculty of Health Sciences




78 Parraga Grace BJI Affiliate Schulich School of Medicine & Dentistry Basic biological & biomedical


79 Patel Rajni BJI Affiliate Faculty of Engineering



80 Penuela Silvia BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical

81 Peters Terry BJI Scientist Schulich School of Medicine & Dentistry

Faculty of Science



82 Petrella Robert BJI Scientist Faculty of Health Sciences



83 Pope Janet BJI Scientist Schulich School of Medicine & Dentistry Clinical & health services

84 Price Aaron BJI Scientist Faculty of Engineering Physical sciences & engineering

85 Ramachandran Rithwik BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical

86 Rasoulinejad Parham BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical


87 Rizkalla Amin BJI Scientist Faculty of Engineering




88 Ryan Bridget BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services


89 Sadi Jackie BJI Scientist Faculty of Health Sciences Clinical & health services

90 Sanders Dave BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services


70


91 Schemitsch Emil BJI Scientist Schulich School of Medicine & Dentistry Clinical & health services

92 Séguin Cheryle BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical

93 Shoemaker Kevin BJI Scientist Faculty of Health Sciences Basic biological & biomedical


94 Stock Jay BJI Affiliate Faculty of Social Science Basic biological & biomedical


95 Suh Nina BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services

96 Teeter Matthew BJI Scientist Schulich School of Medicine & Dentistry Physical sciences & engineering


97 Thain Jenny BJI Affiliate Schulich School of Medicine & Dentistry

98 Thompson Terry BJI Affiliate Schulich School of Medicine & Dentistry

Faculty of Science


99 Trejos Ana Luisa BJI Scientist Faculty of Engineering Physical sciences & engineering

100 Vasarhelyi Edward BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services

101 Walton Dave BJI Scientist Faculty of Health Sciences Clinical & health services

102 Waters-Rist Andrea BJI Affiliate Faculty of Social Science Basic biological & biomedical

103 Willing Ryan BJI Scientist Faculty of Engineering Basic biological & biomedical


104 Willits Kevin BJI Affiliate Schulich School of Medicine & Dentistry Clinical & health services

105 Willmore Katherine BJI Scientist Schulich School of Medicine & Dentistry Basic biological & biomedical

106 Wilson Tim BJI Affiliate Schulich School of Medicine & Dentistry Basic biological & biomedical


107 Wolfe Dalton BJI Affiliate Faculty of Health Sciences Clinical & health services

108 Zdero Radovan BJI Affiliate Faculty of Engineering





71

Appendix B – BJI Trainee and Staff Membership List

Trainee and Staff BJI Membership List

BJI CMHR Trainees Faculty Career Stage

1 Abbott Mark Schulich School of Medicine & Dentistry MSc

2 Al-Khazraji Baraa Faculty of Health Sciences PDF

3 Arsenault Dominique Faculty of Health Sciences MSc

4 Arshad Rooshan Faculty of Engineering MSc

5 Atkinson Hayden Faculty of Health Sciences PhD

6 Baha Pardis Schulich School of Medicine & Dentistry MSc

7 Baronette Rudy Schulich School of Medicine & Dentistry MSc

8 Bellini Melina Schulich School of Medicine & Dentistry PhD

9 Blokker Alexandra Faculty of Engineering MSc

10 Bobos Pavlos Faculty of Health Sciences PhD

11 Broberg Jordan Schulich School of Medicine & Dentistry MSc

12 Carranza Victor Faculty of Engineering MSc

13 Cobos Cobos Santiago Schulich School of Medicine & Dentistry PhD

14 Docter Shgufta Faculty of Health Sciences PhD

15 El Najjar Mai Faculty of Engineering MSc

16 Esseltine Jessica Lynn Schulich School of Medicine & Dentistry PDF

17 Farago Emma Faculty of Engineering MSc

18 Fennema Megan Schulich School of Medicine & Dentistry MSc

19 Fournier Dale Schulich School of Medicine & Dentistry MSc

20 Haddara Mohammad Faculty of Engineering MSc

21 Hannon Ashley Nicole Schulich School of Medicine & Dentistry PDF

22 Hart Harvi Faculty of Health Sciences PDF

23 Hijazi Ayten Schulich School of Medicine & Dentistry PDF

24 Hijazi Khaled Marwan Anis Faculty of Engineering PhD

25 Holland Sara Faculty of Engineering MSc

26 Hong Gregory Schulich School of Medicine & Dentistry PhD


72


27 Ioussoufovitch Seva Schulich School of Medicine & Dentistry Msc

28 Jeffery William Faculty of Health Sciences MSc

29 Jennings Morgan Faculty of Health Sciences MSc

30 Jewlal Elizabeth Schulich School of Medicine & Dentistry MSc

31 Juignet Laura Schulich School of Medicine & Dentistry PDF

32 Kamoun Hisham Faculty of Engineering MSc

33 Kanko Lauren Faculty of Health Sciences MSc

34 Kerr Geoffrey Schulich School of Medicine & Dentistry PhD

35 Khan Michaela Faculty of Health Sciences MSc

36 Kim Brandon Schulich School of Medicine & Dentistry MSc

37 Kim Mark Schulich School of Medicine & Dentistry PhD

38 Knowles Nikolas K. Faculty of Engineering PhD

39 Kornmuller Anna Faculty of Engineering PhD

40 Lai-Zhao Yue Schulich School of Medicine & Dentistry MSc

41 Langohr Gordon Daniel George Schulich School of Medicine & Dentistry PDF

42 Leitch Kristyn Schulich School of Medicine & Dentistry PDF

43 Liang Yu-Ting (Natalie) Faculty of Science MSc

44 Lorusso Daniel Schulich School of Medicine & Dentistry PhD

45 Lowndes Ashley Faculty of Health Sciences MSc

46 Lukacs Michael Faculty of Health Sciences PhD

47 Luo Johnny Schulich School of Medicine & Dentistry MSc

48 McLeod Karrington Faculty of Engineering MSc

49 Murphy Patrick Schulich School of Medicine & Dentistry MSC

50 Naghibosadat Maedeh Schulich School of Medicine & Dentistry MSc

51 Nazari Goris Faculty of Health Sciences PhD

52 O'Neill Lindsey Faculty of Health Sciences MSc

53 Padmore Clare Elizabeth Faculty of Engineering PhD

54 Paish Adam Schulich School of Medicine & Dentistry PhD

55 Peidl Alex Schulich School of Medicine & Dentistry MSc

56 Perelgut Maxwell Faculty of Engineering MSc


73


57 Pest Micheal Schulich School of Medicine & Dentistry PDF

58 Pinto Ryan Faculty of Health Sciences PhD

59 Pitchers Kyle Schulich School of Medicine & Dentistry PDF

60 Primeau Codie Faculty of Health Sciences PhD

61 Ratneswaran Anusha Schulich School of Medicine & Dentistry PDF

62 Reeves Jacob Faculty of Engineering PhD

63 Remtulla Alliya Faculty of Health Sciences PhD

64 Riddle Michael Faculty of Engineering MSc

65 Schulz Jenna Faculty of Health Sciences PhD

66 Serack Fiona Faculty of Engineering PhD

67 Serjeant Meaghan Schulich School of Medicine & Dentistry MSc

68 Sharma Nadia Faculty of Engineering MSc

69 Shridhar Arthi Faculty of Engineering PhD

70 Sood Arusha Faculty of Health Sciences Undergrad

71 Sun Emmy Schulich School of Medicine & Dentistry Undergrad

72 Sun Margaret Man-Ger Schulich School of Medicine & Dentistry PhD

73 Tam Clara Faculty of Engineering MSc

74 Tanashi Ahmed Faculty of Engineering MSc

75 Thom Mitchell Schulich School of Medicine & Dentistry MSc

76 To Bethia Schulich School of Medicine & Dentistry MSc

77 Van de Kleut Madeleine Faculty of Engineering PhD

78 Veras Matthew Schulich School of Medicine & Dentistry PhD

79 Villamagna Ian Faculty of Engineering PhD

80 Wakefield Brent Schulich School of Medicine & Dentistry PhD

81 Wambiekele

Kiyeko

Gaelle Schulich School of Medicine & Dentistry PDF

82 Webster Jared Faculty of Health Sciences PhD

83 West Emily Faculty of Engineering MSc

84 White Ian Schulich School of Medicine & Dentistry Undergrad

85 Williams Harley Schulich School of Medicine & Dentistry MSc

86 Wong Matthew Faculty of Health Sciences Undergrad


74


87 Yacoub Daniel Faculty of Health Sciences Undergrad

88 Zhou Yue Faculty of Engineering PhD

89 Zomar Bryn Olivia Faculty of Health Sciences PhD

BJI Non-CMHR Trainees Faculty Member Status

1 Akingbasote James Schulich School of Medicine & Dentistry BJI Trainee

2 Allen James Schulich School of Medicine & Dentistry BJI Trainee

3 Maggiano Corey Faculty of Social Science BJI Trainee

4 McCracken Laura Faculty of Engineering BJI Trainee

5 Mehta Swati Faculty of Health Sciences BJI Trainee

6 Mondal Dibakar Faculty of Engineering BJI Trainee

7 Moon Paxton Schulich School of Medicine & Dentistry BJI Trainee

8 Neuert Mark Faculty of Engineering BJI Trainee

9 Ochotny Noelle Schulich School of Medicine & Dentistry BJI Trainee

10 Sadowski Eric Faculty of Health Sciences BJI Trainee

11 Stokes Matthew Faculty of Engineering BJI Trainee

12 Supinder Kour Bali Schulich School of Medicine & Dentistry BJI Trainee

13 Tenn Neil Schulich School of Medicine & Dentistry BJI Trainee

14 Tse Justin Schulich School of Medicine & Dentistry BJI Trainee

15 Valladares Katya Faculty of Social Science BJI Trainee

16 Versteegh Theo Faculty of Health Sciences BJI Trainee

17 Wang Jack Faculty of Health Sciences BJI Trainee

18 Yuan Xunhua Schulich School of Medicine & Dentistry BJI Trainee

Partners, Collaborators & Staff Faculty Member Status

1 Anderson Robert Faculty of Social Science BJI Partner

2 Barmby Pauline Faculty of Science BJI Partner

3 Barrett David Affiliates BJI Partner

4 Beach Ryan Schulich School of Medicine & Dentistry Staff

5 Bingham Clifton External BJI Partner

6 Boyle Jennifer External BJI Partner


75

7 Bryce Dawn-Marie Schulich School of Medicine & Dentistry Staff

8 Callaghan Patrick Affiliates Staff

9 Capone John Affiliates BJI Partner

10 Cechetto Lisa Affiliates BJI Partner

11 Chrones Tom Schulich School of Medicine & Dentistry Staff

12 Coderre John External BJI Partner

13 Cole Kelly Affiliates BJI Partner

14 Connell Helen Affiliates BJI Partner

15 Dupuis David Schulich School of Medicine & Dentistry Staff

16 Elliott Ray External BJI Partner

17 Garland S. Jayne Faculty of Health Sciences BJI Partner

18 Hankenson Kurt External BJI Partner

19 Hill David External BJI Partner

20 Hofstetter Cathie External BJI Partner

21 Hrabok Katherine Schulich School of Medicine & Dentistry Staff

22 Hrymak Andrew Faculty of Engineering BJI Partner

23 Hurtig Mark External at Guelph BJI Affiliate

24 Ivanov Todor Schulich School of Medicine & Dentistry Staff

25 Katsivo Melanie Schulich School of Medicine & Dentistry Staff

26 Koschinsky Marlys Affiliates BJI Partner

27 Lyddiatt Anne External BJI Partner

28 Miller Linda Affiliates BJI Partner

29 Mundy Samantha Affiliates Staff

30 Paquette-Warren Jann Affiliates Staff

31 Rayman Reiza External BJI Partner

32 Richards Carl External BJI Partner

33 Rorabeck Cecil External BJI Partner

34 Sims Stephen Schulich School of Medicine & Dentistry BJI Partner

35 Strong Michael Schulich School of Medicine & Dentistry BJI Partner

36 Szekeres Mike Faculty of Health Sciences BJI Affiliate

37 Urquhart Jennifer Schulich School of Medicine & Dentistry Staff

38 Woodhouse Shannon Affiliates Staff

39 Zernicke Ron External BJI Partner


76

Appendix C – Publications

1. Emily, A. W., Nikolas, K. K., George, S. A., & Louis, M. F. (2017). A 3D comparison of humeral head

retroversion by sex and measurement technique. Shoulder & Elbow, 1758573217711897.

doi:10.1177/1758573217711897

2. Heath, M., Shellington, E., Titheridge, S., Gill, D. P., & Petrella, R. J. (2017). A 24-Week Multi-√•Modality

Exercise Program Improves Executive Control in Older Adults with a Self-Reported Cognitive Complaint:

Evidence from the Antisaccade Task. J Alzheimers Dis, 56(1), 167-183. doi:10.3233/jad-160627

3. Nazemi, S. M., Kalajahi, S. M. H., Cooper, D. M. L., Kontulainen, S. A., Holdsworth, D. W., Masri, B. A.,

Wilson, D. R., & Johnston, J. D. (2017). Accounting for spatial variation of trabecular anisotropy with

subject-specific finite element modeling moderately improves predictions of local subchondral bone stiffness

at the proximal tibia. Journal of Biomechanics, 59, 101-108. doi:10.1016/j.jbiomech.2017.05.018

4. Elliott, J. M., Hancock, M. J., Crawford, R. J., Smith, A. C., & Walton, D. M. (2017). Advancing imaging

technologies for patients with spinal pain: with a focus on whiplash injury. Spine J.

doi:10.1016/j.spinee.2017.06.015

5. Boonnoy, P., Karttunen, M., & Wong-ekkabut, J. (2017). Alpha-tocopherol inhibits pore formation in

oxidized bilayers. Physical Chemistry Chemical Physics, 19(8), 5699-5704. doi:10.1039/c6cp08051k

6. Lemaster, K., Jackson, D., Welsh, D. G., Brooks, S. D., Chantler, P. D., & Frisbee, J. C. (2017). Altered

distribution of adrenergic constrictor responses contributes to skeletal muscle perfusion abnormalities in

metabolic syndrome. Microcirculation, 24(2). doi:10.1111/micc.12349

7. Lemaster, K. A., Farid, Z., Brock, R. W., Shrader, C. D., Goldman, D., Jackson, D. N., & Frisbee, J. C.

(2017). Altered post-capillary and collecting venular reactivity in skeletal muscle with metabolic syndrome.

Journal of Physiology-London, 595(15), 5159-5174. doi:10.1113/jp274291

8. Poursartip, B., LeBel, M. E., Patel, R., Naish, M., & Trejos, A. L. (2017). Analysis of Energy-based Metrics

for Laparoscopic Skills Assessment. IEEE Trans Biomed Eng. doi:10.1109/tbme.2017.2706499

9. Glennie, R. A., Bailey, C. S., Tsai, E. C., Noonan, V. K., Rivers, C. S., Fourney, D. R., Ahn, H., Kwon, B.

K., Paquet, J., Drew, B., Fehlings, M. G., Attabib, N., Christie, S. D., Finkelstein, J., Hurlbert, R. J., Parent,

S., Dvorak, M. F., & Network, R. (2017). An analysis of ideal and actual time to surgery after traumatic

spinal cord injury in Canada. Spinal Cord, 55(6), 618-623. doi:10.1038/sc.2016.177

10. Reeves, J. M., Johnson, J. A., & Athwal, G. S. (2017). An analysis of proximal humerus morphology with

special interest in stemless shoulder arthroplasty. Journal of Shoulder and Elbow Surgery.

doi:https://doi.org/10.1016/j.jse.2017.10.029

11. Dhollander, A., & Getgood, A. (2017). Anterolateral Complex Reconstruction: Who, When, and How?

Operative Techniques in Orthopaedics, 27(2), 139-144. doi:10.1053/j.oto.2017.02.010

12. Makino, K., Makino, T., Stawski, L., Lipson, K. E., Leask, A., & Trojanowska, M. (2017). Anti-connective

tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic

sclerosis. Arthritis Res Ther, 19(1), 134. doi:10.1186/s13075-017-1356-3

13. Bell, D. A., Elhayek, S., Cairns, E., & Barra, L. (2017). Anti-homocitrullinated protein antibody isotype

usage in rheumatoid arthritis and their unaffected first-degree relatives. Clinical and Experimental

Rheumatology, 35(6), 948-953.

14. Murphy-Marshman, H., Quensel, K., Shi-Wen, X., Barnfield, R., Kelly, J., Peidl, A., Stratton, R. J., & Leask,

A. (2017). Antioxidants and NOX1/NOX4 inhibition blocks TGFbeta1-induced CCN2 and alpha-SMA

expression in dermal and gingival fibroblasts. PLoS One, 12(10), e0186740.

doi:10.1371/journal.pone.0186740

15. Abady, A. H., Rosedale, R., Chesworth, B. M., Rotondi, M. A., & Overend, T. J. (2017). Application of the

McKenzie system of Mechanical Diagnosis and Therapy (MDT) in patients with shoulder pain; a prospective

longitudinal study. Journal of Manual & Manipulative Therapy, 25(5), 235-243.

doi:10.1080/10669817.2017.1313929


77

16. Kozachuk, M. S., Martin, R. R., Sham, T. K., Robinson, M., & Nelson, A. J. (2017). The application of

XANES for the examination of silver, gold, mercury, and sulfur on the daguerreotype surface. Canadian

Journal of Chemistry, 95(11), 1156-1162. doi:10.1139/cjc-2017-0062

17. Ratneswaran, A., & Beier, F. (2017). An approach towards accountability: suggestions for increased

reproducibility in surgical destabilization of medial meniscus (DMM) models. Osteoarthritis Cartilage,

25(11), 1747-1750. doi:10.1016/j.joca.2017.07.018

18. Micolini, C., Holness, B. F., Johnson, A. J., & Price, D. A. (2017). Assessment of Embedded Conjugated

Polymer Sensor Arrays for Potential Load Transmission Measurement in Orthopaedic Implants. Sensors,

17(12). doi:10.3390/s17122768

19. Marriott, K. A., Birmingham, T., Moyer, R., Kanko, L., Pinto, R., Primeau, C., & Giffin, R. (2017).

ASSOCIATION BETWEEN HIGH EXTERNAL KNEE ADDUCTION MOMENT AND INCREASED

PAIN DURING WALKING: WITHIN-LIMB COMPARISONS IN PATIENTS WITH MEDIAL

COMPARTMENT KNEE OSTEOARTHRITIS. Osteoarthritis and Cartilage, 25, S112-S112.

doi:10.1016/j.joca.2017.02.180

20. Frengnpoillnc, C., Burley, J., Viana, R., Payne, M. W., & Hunter, S. W. (2017). Association Between

Montreal Cognitive Assessment Scores and Measures of Functional Mobility in Lower Extremity Amputees

After Inpatient Rehabilitation. Arch Phys Med Rehabil, 98(3), 450-455. doi:10.1016/j.apmr.2016.06.012

21. Fortin, M., Lazary, A., Varga, P. P., & Battie, M. C. (2017). Association between paraspinal muscle

morphology, clinical symptoms and functional status in patients with lumbar spinal stenosis. European Spine

Journal, 26(10), 2543-2551. doi:10.1007/s00586-017-5228-y

22. Montero-Odasso, M. M., Sarquis-Adamson, Y., Speechley, M., Borrie, M. J., Hachinski, V. C., Wells, J.,

Riccio, P. M., Schapira, M., Sejdic, E., Camicioli, R. M., Bartha, R., McLlroy, W. E., & Muir-Hunter, S.

(2017). Association of Dual-Task Gait With Incident Dementia in Mild Cognitive Impairment Results From

the Gait and Brain Study. Jama Neurology, 74(7), 857-865. doi:10.1001/jamaneurol.2017.0643

23. Muir-Hunter, S. W., & Montero-Odasso, M. (2017). The attentional demands of ambulating with an assistive

device in older adults with Alzheimer's disease. Gait & Posture, 54, 202-208.

doi:10.1016/j.gaitpost.2017.03.011

24. Lepore, N., Cashin, M., Bartley, D., & Ardelean, D. S. (2017). Atypical monoarthritis presentation in

children with oligoarticular juvenile idiopathic arthritis: a case series. Pediatric Rheumatology, 15.

doi:10.1186/s12969-016-0129-x

25. Xiaoxu, H., Mark, L., Stephanie, L., James, W., Olga, S., & Shuo, L. (2017). - Automated grading of lumbar

disc degeneration via supervised distance metric learning. - 10134(-), - 10134-10137.

26. Merritt, K. E., Seergobin, K. N., Mendonca, D. A., Jenkins, M. E., Goodale, M. A., & MacDonald, P. A.

(2017). Automatic Online Motor Control Is Intact in Parkinson's Disease With and Without Perceptual

Awareness. eNeuro, 4(5). doi:10.1523/eneuro.0215-17.2017

27. Balestrini, C. S., Moir, M. E., Abbott, K. C., Johnson, M., Fischer, L. K., Fraser, D. D., & Shoemaker, J. K.

(2017). Autonomic Dysregulation in Adolescent Concussion: Characterization and Temporal Resolution of

Neurological Outcomes. The FASEB Journal, 31(1_supplement), 863.863-863.863.

doi:10.1096/fasebj.31.1_supplement.863.3

28. Barkwell, G. E., & Dickey, J. P. (2017). Backstroke start performance: the impact of using the Omega OBL2

backstroke ledge. Sports Biomechanics, 1-13. doi:10.1080/14763141.2017.1353130

29. MacDermid, J. C. (2017). Bias‚Ä¶can occur during the research or publication process. Journal of Hand

Therapy, 30(4), 381-382. doi:https://doi.org/10.1016/j.jht.2017.10.005

30. Lanting, B. A., Hartley, K. C., Raffoul, A. J., Burkhart, T. A., Sommerville, L., Martin, G. R., Howard, J. L.,

& Johnson, M. (2017). Bikini versus traditional incision direct anterior approach: is there any difference in

soft tissue damage? Hip International, 27(4), 397-400. doi:10.5301/hipint.5000478

31. Aziz, M. S. R., Dessouki, O., Samiezadeh, S., Bougherara, H., Schemitsch, E. H., & Zdero, R. (2017).

Biomechanical analysis using FEA and experiments of a standard plate method versus three cable methods


78

for fixing acetabular fractures with simultaneous THA. Med Eng Phys, 46, 71-78.

doi:10.1016/j.medengphy.2017.06.004

32. Sarwar, A., Srivastava, S., Chu, C., Machin, A., Schemitsch, E. H., Bougherara, H., Bagheri, Z. S., & Zdero,

R. (2017). Biomechanical Measurement Error Can Be Caused by Fujifilm Thickness: A Theoretical,

Experimental, and Computational Analysis. Biomed Res Int, 2017, 4310314. doi:10.1155/2017/4310314

33. Cook, G. E., Samiezadeh, S., Morison, Z., Aziz, M. S., Bougherara, H., Zdero, R., & Schemitsch, E. H.

(2017). Biomechanical optimization of the angle and position for surgical implantation of a straight short

stem hip implant. Med Eng Phys, 39, 23-30. doi:10.1016/j.medengphy.2016.10.002

34. Kerr, G. J., McCann, M. R., Branch, J. K., Ratneswaran, A., Pest, M. A., Holdsworth, D. W., Beier, F.,

Dixon, S. J., & Seguin, C. A. (2017). C57BL/6 mice are resistant to joint degeneration induced by whole-

body vibration. Osteoarthritis and Cartilage, 25(3), 421-425. doi:10.1016/j.joca.2016.09.020

35. Cuthbert, T. J., Evoy, E., Bow, J. P. J., Guterman, R., Stubbs, J. M., Gillies, E. R., Ragogna, P. J., &

Blacquiere, J. M. (2017). CapturePhos - A phosphorus-rich polymer as a homogeneous catalyst scavenger.

Catalysis Science & Technology, 7(13), 2685-2688. doi:10.1039/c7cy00391a

36. Inoue, K., Patterson, E. K., Capretta, A., Lawendy, A. R., Fraser, D. D., & Cepinskas, G. (2017). Carbon

Monoxide-Releasing Molecule-401 Suppresses Polymorphonuclear Leukocyte Migratory Potential by

Modulating F-Actin Dynamics. American Journal of Pathology, 187(5), 1121-1133.

doi:10.1016/j.ajpath.2016.12.025

37. Zamir, M., Badrov, M. B., Olver, T. D., & Shoemaker, J. K. (2017). Cardiac Baroreflex Variability and

Resetting during Sustained Mild Effort. Front Physiol, 8, 246. doi:10.3389/fphys.2017.00246

38. Aleksanderek, I., McGregor, S. M. K., Stevens, T. K., Goncalves, S., Bartha, R., & Duggal, N. (2017).

Cervical Spondylotic Myelopathy: Metabolite Changes in the Primary Motor Cortex after Surgery.

Radiology, 282(3), 817-825. doi:10.1148/radiol.2016152083

39. Birmingham, T. B., Moyer, R., Leitch, K., Chesworth, B., Bryant, D., Willits, K., Litchfield, R., Fowler, P.

J., & Giffin, J. R. (2017). Changes in biomechanical risk factors for knee osteoarthritis and their association

with 5-year clinically important improvement after limb realignment surgery. Osteoarthritis and Cartilage,

25(12), 1999-2006. doi:10.1016/j.joca.2017.08.017

40. Babatunde, F., MacDermid, J., & MacIntyre, N. (2017). Characteristics of therapeutic alliance in

musculoskeletal physiotherapy and occupational therapy practice: a scoping review of the literature. BMC

Health Services Research, 17(1), 375. doi:10.1186/s12913-017-2311-3

41. Li, Y. M., Matinmanesh, A., Curran, D. J., Schemitsch, E. H., Zalzal, P., Papini, M., Wren, A. W., & Towler,

M. R. (2017). Characterization and fracture property of different strontium-containing borate-based glass

coatings for Ti6Al4V substrates. Journal of Non-Crystalline Solids, 458, 69-75.

doi:10.1016/j.jnoncrysol.2016.12.010

42. Chan, K., Knowles, N. K., Chaoui, J., Gauci, M. O., Ferreira, L. M., Walch, G., & Athwal, G. S. (2017).

Characterization of the Walch B3 glenoid in primary osteoarthritis. Journal of Shoulder and Elbow Surgery,

26(5), 909-914. doi:10.1016/j.jse.2016.10.003

43. Furey, M. J., Zdero, R., & McKee, M. D. (2017). Clavicular Refracture at the Site of Angular Malunion in

Young Athletes. J Orthop Trauma, 31(4), e130-e132. doi:10.1097/bot.0000000000000765

44. Somerville, L. E., Willits, K., Johnson, A. M., Litchfield, R., LeBel, M. E., Moro, J., & Bryant, D. (2017).

Clinical Assessment of Physical Examination Maneuvers for Superior Labral Anterior to Posterior Lesions.

Surgery Journal-New York, 3(4), e154-e162. doi:10.1055/s-0037-1606829

45. Richard, N., Hudson, M., Gyger, G., Baron, M., Sutton, E., Khalidi, N., Pope, J. E., Carrier, N., Larche, M.,

Albert, A., Fortin, P. R., Thorne, C., Masetto, A., & Canadian Scleroderma Res, G. (2017). Clinical

correlates of faecal incontinence in systemic sclerosis: identifying therapeutic avenues. Rheumatology, 56(4),

581-588. doi:10.1093/rheumatology/kew441


79

46. McCalden, R. W., Hart, G. P., MacDonald, S. J., Naudie, D. D., Howard, J. H., & Bourne, R. B. (2017).

Clinical Results and Survivorship of the GENESIS II Total Knee Arthroplasty at a Minimum of 15 Years.

Journal of Arthroplasty, 32(7), 2161-2166. doi:10.1016/j.arth.2017.02.006

47. Walton, D. M., Kwok, T. S. H., Mehta, S., Loh, E., Smith, A., Elliott, J., Kamper, S. J., Kasch, H., &

Sterling, M. (2017). Cluster Analysis of an International Pressure Pain Threshold Database Identifies 4

Meaningful Subgroups of Adults With Mechanical Neck Pain. Clinical Journal of Pain, 33(5), 422-428.

doi:10.1097/ajp.0000000000000421

48. Kuljanin, M., Brown, C. F. C., Raleigh, M. J., Lajoie, G. A., & Flynn, L. E. (2017). Collagenase treatment

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“A Vision of Lifelong Mobility” - Bone & Jointboneandjoint.uwo.ca/documents/Annual Report 2017.pdf · 2020-03-03 · In some cases, early stage disease will appear in our youth