ANTIPHOSPHOLIPID SYNDROME

AIMSAntiphospholipid syndrome Pathophysiology diagnosis Treatment in pregnancy

APS/APLS/HUGHES SYNDROME

Autoimmune, hypercoagulable state caused by antibodies against cell-membrane phospholipids. Leads to thrombosis and pregnancy related complications such as miscarriage, stillbirth, preterm delivery and severe preeclampsia

BURDEN OF DISEASE

CMACH:

ANTIPHOSPHOLIPID SYNDROMEThrombosis (venous, arterial, microcirculation) and/or Pregnancy morbidity

>3 consecutive miscarriage 1 fetal death > 10 weeks >1 preterm birth