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Antidiarrheal Therapy by Dr.Hamed Daghzghzadeh. Diarrhea is loosely defined as passage of abnormally liquid or unformed Stool at an increased frequency . For adults on a typically western Diet, stool weight exceeding 200g/d Can generally be considered diarrheal. - PowerPoint PPT Presentation
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Antidiarrheal Therapy
byDr.Hamed Daghzghzadeh
Diarrhea is loosely defined as passage
of abnormally liquid or unformedStool at an increased frequency.
For adults on a typically westernDiet, stool weight exceeding 200g/dCan generally be considered diarrheal.
Epidemiology of Acute Diarrhea
Worldwide >1000,000,000 people/year
5-8 million deaths / year
in developing countries
►Secretory diarrhea►Osmotic diarrhea►Inflammatory ( exudative )
diarrhea
►Motility ( dismotile ) diarrhea►Anatomic( absorptive surface)
Pathophysiologic classification of diarrhea
Major Causes of Acute Diarrhea 8
► INFECTIONS (Including Travelers Diarrhea)Bacterial : Campylobactre Species, C.difficile, E.coli, Salmonella eneritides
, Shigella SpeciesParasitic/protozoal : E. histolytica, Giardia lambilia,Cryptosporidium ,CyclospoaViral : Adenovirus , Norwalk virus , Rotavirus ,AIDS, OthersFungal► FOOD POISONING : B.Cereus , C . Perfringens , Salmonella species ,
S .aureus, Vibrio species, Shigella species , Camppylobacter.jejuni, E.coli► MEDICATIONS► RECENT INGESTION OF LARGE AMOUNT OF
POORLY ABSORBABLE SUGARS► INTESTINAL ISCHEMIA► FECAL IMPACTION► PELVIC INFLAMMATION► GRAFT VS HOST DISEASE
Most acute diarrheas are due to
infectious diseases that have limited
courses from a few days to a few
weeks.
MAJOR CAUSES OF CHRONIC DIARRHEA► IBS► IBD► Ischemic bowel disease► Chronic bacterial / mycobacterial infection► Parasitic & fungal infections► Radiation enteritis► Malabsorption Syndromes► Medications, Alcohol► Colon cancer , Villous Adenoma ,intestinal
Lymphoma► Diverticulitis► Previous Surgery ( gastrectomy, vagatomy, intestinal
resection )► Endocrine causes► Fecal impaction► Heavy metal poisoning► Epidemic idiopathic chronic diarrhea
NONSPECIFIC Rx OF
DIARRHEA
The most important Rx for diarrhea is to
ensure that fluid and
electrolyte deficits are replenished with IV or oral rehydration
solution.
ORS
►The rate of replacement should match the clinical presentation.
Empiric Therapy
of Acute Diarrhea
Aminoacid & Glucose absorption accelerates sodium and fluid absorption
in the jejunum.
Saline solutions containing glucose or amino acids will be absorbed readily
Oral rehydration solutions increase
fluid and electrolyte absorption; they are
not designed to reduce stool output,
so stool weight actually may increase
with their use.
Infection is a frequent cause of acute
diarrhea.
If the prevalence of bacterial or protozoal infection is high in a
community or in a specific situation, empiric use of antibiotics is logical.
as in the treatment of travelers' diarrhea
Even without bacteriologic
proof of infection.
Empiric antibiotic therapy is often also logically
used for more severely ill
patients while awaiting bacterial culture results.
Adachi JA, Zeichner LO, DuPont HL, Ericsson CD: Empirical antimicrobial therapy for traveler's diarrhea. Clin Infect Dis 31:1079, 2000.
Ciprofluxacine 500 mg Q12h ( 3 days)
OrAzythromycin 1000 mg single
dose
Experts also advise against empiric
treatment of salmonellosis unless
enteric fever is present. Sirinavin S, Garner P: Antibiotics for treating salmonella gut infections.
Cochrane Database Syst Rev 30:CD001167, 2000.
Nonspecific antidiarrheal agents
can reduce stool frequency and stool weight and can reduce coexisting symptoms, such as abdominal cramps
Opiates, such as loperamide, or diphenoxylate with atropine frequently are
employed.
Schiller LR: Review article: Anti-diarrhoeal pharmacology and therapeutics. Aliment Pharmacol Ther 9:87, 1995.
Intraluminal agents, such as bismuth subsalicylate
and adsorbents (e.g., kaolin) also may help reduce the fluidity of bowel movements.
Schiller LR: Review article: Anti-diarrhoeal pharmacology and therapeutics. Aliment Pharmacol Ther 9:87, 1995.
Empiric Therapy of Chronic Diarrhea
is used in three situations: (1) Initial treatment before diagnostic
testing; (2) After diagnostic testing has failed
to confirm a diagnosis(3) When a diagnosis has been made
but no specific treatment is available or specific treatment has failed to produce a cure.
Generally, empiric antibiotic therapy is
less useful in chronic diarrhea
than in acute diarrhea.
In chronic diarrhea an empiric course of metronidazole or a
fluoroquinolone before extensive diagnostic
testing, is not recommended.
►Remember that diarrhea can be a prominent symptom of malaria.
Other drugs
►VERAPAMIL►NIFEDIPENEREDUCE MOTILITYINCREASE ABSORBTION
Travelers' diarrhea
Travelers' diarrhea affects
30% to 50% of travelers to developing
countries.
Enterotoxigenic Escherichia coli (ETEC)
is the most common cause of travelers'
diarrhea worldwide
Other causes of travelers' diarrhea
►Shigella ►Campylobacter►Aeromonas,► Plesiomonas,►Vibrio►Rotaviruses►Norwalk virus►Giardia
Most cases of travelers' diarrhea
occur between 5 and 15 days after
arrival.
►Persons with gastric hypoacidity and immunosuppressed patients are probably at greater risk of developing travelers' diarrhea.
►Most bouts of travelers' diarrhea are self-limited, with resolution after 4 to 6 days
The illness is heralded by
malaise, anorexia, and abdominal
cramps, followed by watery, usually
nonbloody, diarrhea
►In some cases, nausea and vomiting may be a prominent component
How to prevent Travelers' diarrhea?
Bcause travelers' diarrhea is contracted by the ingestion of
fecally contaminated food or water.
The first line of defense for the traveler is care in selecting food and beverages.
►The first approach is chemoprophylaxis using either antibiotics or bismuth to prevent diarrhea.
The most widely used approach to travelers' diarrhea is probably the provision of antibiotics to be used by the traveler, if and when diarrhea strikes.
Antibiotic prophylaxis is indicated for travelers (to high risk countries), with
1.Gastric achlorhydria2.IBD3.Immunocompromise
A reasonable current recommendation is to provide a three-day course of a quinolone for travelers to most developing countries.
The patient is told to begin the antibiotic when diarrhea starts and to continue treatment for
3 days.
A quinolone represents the drug of choice for travelers if antibiotic prophylaxis is used or for the treatment of travelers' diarrhea.
A single daily dose of ciprofloxacin (500 mg) had a
protective efficacy of 94%.
Norfloxacin in a daily dose of 400 mg had a protective efficacy of 93% .
►Chemoprophylaxis with bismuth is moderately effective (approximately 65%) in preventing diarrhea.
►Two bismuth tablets(240mgx2) taken four times daily.
It needs to be emphasized before travel that self-treatment regimens are not appropriate for the traveler with
bloody diarrhea, severe abdominal pain, high fever
The disadvantagesrelate to the possibility of 1-side effects 2-selection of antibiotic-resistant organisms.
The advantage of prophylactic antibiotics
is their high efficacy in preventing disease.
Finally, the most important
component of self-treatment is the replacement of the fluid and electrolytes lost during diarrhea.
Watery diarrhea that occurs later after return or that persists longer than 10 days despite antibiotic therapy is most commonly
Giardia lamblia infection.
If the diarrhea fails to respond to metronidazole,
a gastrointestinal evaluation should be
performed.
The diagnostic & therapeutic
considerations differ somewhat for
bloody diarrhea, and the pace of the
workup should be accelerated.
Indications of antibiotic coverage wether or not a causative organism is
discovered in acute diarrhea 3
1. Immunecompromised patient.2. Mechanical heart valves or
recent vascular graft.3. Elderly.
Thank you
Constipation
Constipation
►Constipation, or associated symptoms, afflicts many people in the Western world.
The prevalence is greatest among children and the elderly.
►Many people ignore the symptoms or treat themselves by dietary modification or over-the-counter remedies.
PRESENTING SYMPTOMS
►Aperson who says "I am constipated" is either conscious of an unpleasant sensation related to bowel movements or believes that bowel function is abnormal.
►6% - 23% of subjects said in response to interview that they had experienced constipation during the past 12 months.
►At least 10% of the subjects experienced difficulty in defecation at least once a month.
►More women than men regard themselves as constipated.
CLINICAL DEFINITION AND CLASSIFICATIONA
►Clinical definition of constipation needs to take account of both difficult defecation and infrequent stools.
General Factors►Sex►Age ►Nationality ►Diet ►Exercise and Daily Activity
Defecatory Function
►Failure of Relaxation of the Anal Sphincter Complex
►Ineffective Straining ►Diminished Rectal Sensation
►Size and Consistency of Stool
Psychological and Behavioral Factors
►Personality affects stool size and consistency.
CONSTIPATION AS A MANIFESTATION OF
SYSTEMIC DISORDERS
►Hypothyroidism
►Diabetes Mellitus
►Hypercalcemia
CONSTIPATION AS A MANIFESTATION OF CENTRAL
NERVOUS SYSTEM DISEASE OR EXTRINSIC NERVE SUPPLY TO THE
GUT ►Loss of Conscious Control ►Parkinson's Disease►Multiple Sclerosis ►Spinal Cord Lesions
CONSTIPATION SECONDARY TO STRUCTURAL DISORDERS OF THE COLON, RECTUM, ANUS,
AND PELVIC FLOOR
►Disorders of Smooth Muscle
►Enteric Nerves
Disorders of the Anorectum and Pelvic Floor
►Rectocele►Weakness of the Pelvic Floor—
"Descending Perineum Syndrome" ►Full-Thickness Rectal Prolapse,
Intrarectal Mucosal Prolapse, and Solitary Rectal Ulcer Syndrome
PSYCHOLOGICAL DISORDERS AS CAUSES OF OR
AGGRAVATING FACTORS IN CONSTIPATION
►Depression► Eating Disorders ►Denied Bowel Movements
CLINICAL ASSESSMENT
►History►Social History ►Physical Examination ►Prospective Use of a Diary Card