A n s w e r s for C M E e x a m i n a t i o n * Identification No. 886-106

June, 1986, issue of the JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Questions 1-33, Adams RM, Fisher AA: J AM ACAD DERMATOL 14:951-969, 1986.

1. e (p 952, c 2, pa 3 - -p 953, c 1, pa 1) 19. c 2. d (p 955, c 1, pa 5) 20. a 3. e (p 955, c I, pa 5) 21. d 4. d (p 956, c 1, pa 2; p 957, Ta VI) 22. c 5. e (p 960, c 2, pa 2) 23. c 6. e (p 958, c 2, pa 2) 24. c 7. b (p 959, c 1, pa 2 - - p a 3) 8. b (p 960, c 2, pa 3) 25. b 9. b (p 961, e 1, pa 4) 26. a

10. c (p964, c2 , p a l ) 27. a , b , c , d , e 11. a (p966, c 1, pa 1) 12. b (p967, c 1, pa2) 28. None of 13. a (p 968, c 1, pa 5 - - e 2, pa 1) the answers 14. e (p 965, c 1, pa 3 - - c 2, pa 1) is correct 15. d (p967, c 1, pa3 ) 29. a , b , c , d , e 16. a (p967, c2 , pa3 ) 30. b , e 17. c (p967, c 1, pa5) 31. a , b , c , d , e 18. b (p967, c2 , p a l ) 32. a , b , c , d , e

33. a, b, c, d, e *p: page; e: column; pa: paragraph; Ta: table.

(p 957, c 2, pa 2) (p 957, c 2, pa 2) (p 957, c 2, pa 2) (p 957, c 1, pa 4) (p 957, c 1, pa 4 - - c 2, pa 1) (p 953, c 2, pa2; p 956, c 1, pa 1; p 960, c 1, pa 4) (p 960, c 1, pa 4) (p 960, c 1, pa 4) (p 957, c 2, pa 4 - -p 958, c 1, pa 1) (p 958, c 2, pa 3)

(p 958, c 2, pa 3) (p 959, c 2, pa 1) (p 958, Ta IX; p 960, c 1, pa 2) (p 960, c 2, pa 3) (p 960, c 2, pa 3)

ABSTRACTS

Inhibition of the complement activation by an adrenal androgen, dehydroepiandrosterone

Hidvegi T, Feher GK, Feher T, et al: Complement 1:201-206, 1984

Dehydroepiandrosterone (DEA) is an androgen natural in the adrenal gland that can inhibit the activation of both com- plement pathways. It blocks the classic path well and the alternative path only moderately. Other steriods that can achieve a block even better and more safely m~ght be devel- oped. Keep watching.

Philip C. Anderson, M.D.

Human plasma and skin blister fluid levels of griseofulvin following a single oral dose

Schafer-Korting M, Korting HC, Mutschler E: Eur J Clin Pharmacol 29:109-113, 1985

In blister fluid, griseofulvin increases up to about 6 hours after a single dose, while the plasma loads twice as fast. The half-value in clearing is 9 to 10 hours. About a day is required to gain equilibrium in all compartments. Ultramicrosize for- mulation may offer some advantages in using a smaller dose for equal amounts in tissue.

Philip C. Andelwon, M.D.

14

Natural killer cell activity in atopic dermatitis: A sequential study

Lever RS, Lesko MJ, Mackie RM, et al: Clin Allergy 15:479-486, 1985

The greater the activity of the atopic dermatitis the more suppressed was the NK (natural killer) function of lympho- cytes over 12 months of this study. A good correlation of IgE in plasma with the clinical activity of the disease was noted also.

Philip C. Anderson, M.D,

Plasma exchange in the treatment of acute systemic lupus erythematosus without circulating immune complexes

Passaleva A, Massai G, Emmi L, et al: Clin Exp Rheumatol 3:255-257, 1985

Plasma exchange therapy (and plasmapheresis) for very severe and acute lupus erythematosus is becoming almost commonplace. Even if circulating immune complexes are not present, it works, at least to lower antinuclear antibodies. Much more experience is needed to decide the utility of it.

Philip C. Anderson, M.D.