ANNUAL ESDR MEETING · ANNUAL ESDR MEETING. ... 33 Concurrent Session 1: Inflammation, Immunity & Infection 1 ... Speed Dating for pre-registered delegates, Coffee Break

2 7– 3 0 S E P T E M B E R 2 017 — S A L Z B U R G , AU S T R I A

W W W. E S D R 2 017.O R G

S K I N . S C I E N C E . H E A LT H

ANNUAL ESDRMEETING

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Welcome Letters ..........................................................................................................................................................................................................................6Complete Daily Program Overview .......................................................................................................................................................................8Social Program ................................................................................................................................................................................................................................12Program at a Glance .................................................................................................................................................................................................................14

DETAILED SCIENTIF IC PROGRAMWednesday 27 September 2017European Epidermal Barrier Research Network (E2BRN) ........................................................................................................18Future Leaders Symposium ...........................................................................................................................................................................................20Dermatoendocrinology .......................................................................................................................................................................................................22

Thursday 28 September 2017Drug Discovery and Translational Medicine .............................................................................................................................................26Eastern European Research .........................................................................................................................................................................................27International Eczema Council Symposium ...............................................................................................................................................28EDEN ..........................................................................................................................................................................................................................................................29Neurobiology of the Skin .................................................................................................................................................................................................30Frontiers in Skin Biology & Dermatology 1 & Plenary Session 1 ....................................................................................31The LEO Pharma Research Foundation Awards 2017 in association with the ESDR .............................32The Evolving Treatment Landscape for Atopic Dermatitis......................................................................................................33Concurrent Session 1: Inflammation, Immunity & Infection 1 .......................................................................................34Concurrent Session 2: Epidermal Structure & Function ...........................................................................................................35Concurrent Session 3: Photobiology & Pigmentation ................................................................................................................36Rudi Cormane Lecture: Masayuki Amagai (Japan) ............................................................................................................................37Special Guest Lecture: Clemens Sedmak (Austria) .........................................................................................................................37

Friday 29 September 2017Immunoglobulin Therapy in Severe Autoimmune Skin Diseases ................................................................................40IL 31: A Novel Key Pro-Inflammatory Cytokine ....................................................................................................................................41PPAR gamma Modulation in the Management of Pilosebaceous Unit Disorders .....................................42Celgene ESDR Guest Lecture: Federica Sallusto (Switzerland) .........................................................................................43Frontiers in Skin Biology & Dermatology 2 & Plenary Session 2 ....................................................................................44MHC-I-opathies: Understanding Common Immunological Pathways .....................................................................45Well Ageing and Skin ..............................................................................................................................................................................................................46Linking Pathophysiology to Clinical Options in Psoriasis: New Insights into IL-23 ..................................47ESDR Guest Lecture: Matthias Mann (Germany) ................................................................................................................................48René Touraine Guest Lecture: G. Paolo Dotto (Switzerland) .................................................................................................48Concurrent Session 4: Genetics & Cell Based Therapy ..............................................................................................................49Concurrent Session 5: Melanoma & Other Skin Cancers ........................................................................................................51Concurrent Session 6: Hair & Other Adnexal Structures ..........................................................................................................52

Saturday 30 September 2017Concurrent Session 7: Inflammation, Immunity & Infection 2 ........................................................................................54Concurrent Session 8: Clinical Outcomes ..................................................................................................................................................55Concurrent Session 9: Wound Healing & Tissue Remodelling .........................................................................................56EADV Guest Lecture: Michael Hertl (Germany) ....................................................................................................................................57EADV/ESDR Clinical Saturday Lectures ........................................................................................................................................................58Epidermal Homeostasis and Rare Disease ..................................................................................................................................................59Skin Epigenetics ..........................................................................................................................................................................................................................60Innovation and Entrepreneurship in Skin Science ..........................................................................................................................61

GENERAL INFORMATIONPosters .....................................................................................................................................................................................................................................................64A-Z Information ............................................................................................................................................................................................................................68Committees/ESDR Information ..............................................................................................................................................................................72Venue Floorplans ........................................................................................................................................................................................................................75Exhibition Floorplan ................................................................................................................................................................................................................81

42nd JSIDThe 42nd Annual Meeting of the Japanese Society for Investigative Dermatology

Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan

Department of Dermatology, Kochi Medical School, Kochi University

Secretariat :

Kimiko Nakajima, M.D., Ph.D.Secretary-General : Meeting Organizer : The Japanese Dermatological Association1-4, Hongo 4-chome, Bunkyo-ku, Tokyo 113-0033, Japan Fax : +81-3-3812-6790

E-mail : [email protected] URL : http: // jsid42.jp/

December 15(Fri.) - 17(Sun.) 2017KOCHI CITY CULTURE PLAZA CULPORT Kochi, JapanShigetoshi Sano, M.D., Ph.D.President

Venue

Dates

Department of Dermatology, Kochi Medical School, Kochi University

‘We’ve got science under your skin’

— 3 —

CONTENT

AcknowledgementSponsors and Exhibitors of the 47th ESDR Meeting 2017

Revealing Biological Secrets

Corporate Partners

Platinum Sponsors

Gold Sponsors

Sponsors

Exhibitors

MEETING

27–30 SEPTEMBER 2017SALZBURG, AUSTRIA ANNUAL

W W W.ESDR2017.ORG

Welcome to ESDR 2017Welcome from the ESDR president

On behalf of the European Society for Dermatological Research (ESDR) – Welcome to Salzburg!Our 2017 meeting is designed to disseminate the latest information about cutting edge research and new approaches to scientific

discovery. The ESDR strives to be particularly attractive to trainees of all levels and to early career skin scientists; for example, by providing ample room for interaction during poster sessions and during the Future Leaders Symposium. Recognizing the importance of translational biomedical research, we bring together academia and biopharma, and include dedicated sessions discussing aspects of drug discovery. New to the program is an exciting session about innovation and entrepreneurship in skin science and the possibility for researchers among themselves and with biopharma to schedule ‘speed dates’ to explore collaborations. The goal of the ESDR is to enable the future of skin science through scientific exchange and education. For the current year, the ESDR has defined five major areas of further development:

1. To link basic with translational research 2. To support early career scientists 3. To provide an educational platform 4. To create an innovation hub between academia and biopharma 5. To provide leadership mentoring 6. To transform the ESDR into an integral

organization with shared leadership

Please provide us with feedback on these areas and enjoy this year’s meetingin the middle of beautiful Salzburg.

Matthias SchmuthPresident, ESDR

Johann BauerESDR 2017

Local Organizing Committee Chair

Welcome from the Local Organizing Committee Chair

Dear colleagues and friends, welcome to the 47th Annual Meeting of the ESDR in Salzburg. Judging from the ongoing registration and abstract handling procedure we expect to have 700+ abstracts

and 1000+ participants from 5 continents. Thus there is ample room for scientific exchange with colleagues from other parts of the world. This interaction is also facilitated by the social events that culminate in the Gala evening on Friday, September 29th in the “Stieglkeller”. Although being called a “Keller”=basement it is nicely located above the roofs of Salzburg’s old town. It is home of the famous “Stieglbier” that is produced by Austria´s largest private brewery. This evening will be garnished by fabulous local food, music and dancing. So together with an outstanding scientific programme the scene is set for a successful meeting in the heart of Europe. Come and enjoy the “Sounds of Dermatology”

— 6 — — 7 —

WELCOME

Complete Daily Program OverviewWednesday 27 September 2017

TIME SESSION LOCATION INFO

11.00–18.45 European Epidermal Barrier Research Network (E2BRN) Mozart Hall 4+5, Ground floor

p 18

13.00–18.00 Future Leaders Symposium Mozart Hall 1+2+3, Ground floor

p 20

14.00–18.00 Dermatoendocrinology Wolf-Dietrich Hall, 1st floor

p 22

18.00–19.00 Satellite Meetings Welcome Reception Foyer, Ground Floor p 12

Thursday 28 September 2017TIME SESSION LOCATION INFO

08.30–10.30 Drug Discovery and Translational Medicine Europa Hall, 2nd floor p 26

08.30–10.30 Eastern European Research Mozart Hall 4+5, Ground floor

p 27

08.30–10.30 International Eczema Council Mozart Hall 1+2+3, Ground floor

p 28

08.30–10.30 EDEN Wolf-Dietrich Hall, 1st floor

p 29

08.30–10.30 Neurobiology of the Skin Papageno Hall, Ground Floor

p 30

10.30–11.00 Coffee Break

11.00–12.45 Opening Ceremony Frontiers in Skin Biology & Dermatology 1 & Plenary Session 1

Europa Hall, 2nd floor p 31

12.45–14.15 The LEO Pharma Research Foundation Awards 2017 in association with the ESDR


13.15–14.15 The Evolving Treatment Landscape for Atopic DermatitisSanofi Genzyme Symposium

Mozart Hall 1+2+3, Ground floor

p 33

14.20–15.45 Concurrent Session 1: Inflammation, Immunity & Infection 1 Europa Hall, 2nd floor p 34

14.20–15.45 Concurrent Session 2: Epidermal Structure & Function Mozart Hall 1+2+3, Ground floor

p 35

14.20–15.45 Concurrent Session 3: Photobiology & Pigmentation Mozart Hall 4+5, Ground floor

p 36

15.50–16.20 Rudi Cormane Lecture: Masayuki Amagai (Japan) Europa Hall, 2nd floor p 37

16.20–17.40 General Poster Viewing Session and Coffee Break Printed poster Area

17.45–17.55 JSID and SID Intersociety Collegiality Awards Europa Hall, 2nd floor

18.00–18.30 Special Guest Lecture: Clemens Sedmak (Austria) Europa Hall, 2nd floor p 37

18.30–18.45 ESDR Honorary Membership Awards Europa Hall, 2nd floor

18.45–21.00 Welcome Reception Foyer, 1st floor p 12

— 8 — — 9 —

OVERVIEW


08.30–09.30 Immunoglobulin Therapy in Severe Autoimmune Skin DiseasesBiotest Symposium

Mozart Hall 4+5, Ground floor

p 40

08.30–09.30 IL 31: A Novel Key Pro-Inflammatory CytokineGalderma Symposium


p 41

08.30–09.30 PPAR gamma Modulation in the Management of Pilosebaceous Unit DisordersNogra Pharma Symposium

Wolf-Dietrich Hall, 1st floor

p 42

09.35–10.05 Celgene ESDR Guest Lecture: Federica Sallusto (Switzerland) Europa Hall, 2nd floor p 43

10.05–11.30 Frontiers in Skin Biology & Dermatology 2 & Plenary Session 2 Europa Hall, 2nd floor p 44

11.30–12.25 Poster Viewing (ODD NUMBERS) and Poster Walks (01-10), Speed Dating for pre-registered delegates, Coffee Break

Printed & Electronic Poster Areas

12.30–14.00 MHC-I-opathies: Understanding Common Immunological PathwaysCelgene Symposium


12.30–14.00 Well Ageing and SkinChanel R&T Symposium

Mozart Hall 4+5, Ground floor

p 46

12.30–14.00 Linking Pathophysiology to Clinical Options in Psoriasis: New Insights into IL-23Janssen Symposium


p 47

14.05–14.35 ESDR Guest Lecture: Matthias Mann (Germany) Europa Hall, 2nd floor p 48

14.35–15.30 Poster Viewing (EVEN NUMBERS) and Poster Walks (11-20), Speed Dating for pre-registered delegates, Coffee Break


15.35–16.05 René Touraine Guest Lecture: G. Paolo Dotto (Switzerland) Europa Hall, 2nd floor p 48

16.10–17.35 Concurrent Session 4: Genetics & Cell Based Therapy Europa Hall, 2nd floor p 49

16.10–17.35 Concurrent Session 5: Melanoma & Other Skin Cancers Mozart Hall 1+2+3, Ground floor

p 51

16.10–17.35 Concurrent Session 6: Hair & Other Adnexal Structures Mozart Hall 4+5, Ground floor

p 52

17.40–18.30 ESDR Annual General Meeting of Members Europa Hall, 2nd floor

19.30–24.00 Social Networking Event Der Stieglkeller, Salzburg

p 12

Friday 29 September 2017


09.00–10.30 Concurrent Session 7: Inflammation, Immunity & Infection 2 Europa Hall, 2nd floor p 54

09.00–10.30 Concurrent Session 8: Clinical Outcomes Mozart Hall 1+2+3, Ground floor

p 55

09.00–10.30 Concurrent Session 9: Wound Healing & Tissue Remodelling Mozart Hall 4+5, Ground floor

p 56

10.30–11.30 General Poster Viewing Session (all authors) and Poster Walks (21-30), Coffee Break


11.35–12.05 EADV Guest Lecture: Michael Hertl (Germany) Europa Hall, 2nd floor p 57

12.10–13.40 EADV/ESDR Clinical Saturday Lectures Europa Hall, 2nd floor p 58

12.15–13.15 Epidermal Homeostasis and Rare Disease Mozart Hall 1+2+3, Ground floor

p 59

13.30–14.00 ESDR Poster Prizes and Closing Ceremony Europa Hall, 2nd floor

14.00–17.00 Skin Epigenetics Mozart Hall 1+2+3, Ground floor

p 60

14.00–17.00 Innovation and Entrepreneurship in Skin Science Mozart Hall 4+5, Ground floor

p 61

Saturday 30 September 2017

Notes

— 10 — — 11 —

OVERVIEW

Satellite Meetings ReceptionDate: Wednesday 27 September 2017, 18.00–19.00

Location: Salzburg Congress Centre

ESDR invites all delegates to a short reception at the meeting venue following the afternoon satellite symposia.

Welcome Receptionand Poster ViewingDate: Thursday 28 September 2017, 18.45–21.00

Location: Foyer, Salzburg Congress Centre

This event is open to all registered ESDR 2017 delegates.Our 2017 welcome reception will take place at the meeting venue around the Poster Area. This is a great opportunity to meet your colleagues and peers while discussing science. Light refreshments will be served.

Social Program

Social Networking EventDate: Friday 29 September 2017, 19.30–24.00

Location: Der Stieglkeller, Salzburg

The 2017 ESDR Social Networking Event will be held at the Stieglkeller, a traditional Austrian venue with a stunning view over Salzburg. The Social Event is a relaxed, informal gathering. Information on travelling to the venue will be given with your entry ticket. We hope to see you all there.Tickets: Can be purchased when you register for the meeting or onsite at the meeting venue.

Thursday, September 28, 2017 | 13:15–14:15 in Mozart Hall 1–3, Salzburg, Austria

THE EVOLVING TREATMENT LANDSCAPE FOR ATOPIC DERMATITIS

E U R O P E A N S O C I E T Y F O R D E R M A T O L O G I C A L R E S E A R C H

S P E A K E R P A N E L

Georg Stingl, MDMedical University of Vienna, Austria

Marjolein de Bruin-Weller, MD, PhDUniversity Medical Centre Utrecht, Netherlands

Tilo Biedermann, MDTechnische Universität München, Germany

Please join a company-sponsored symposium hosted by Sanofi Genzyme and Regeneron Pharmaceuticals

Speakers will receive compensation for their participation in this event.

© 2017 Sanofi Genzyme and Regeneron Pharmaceuticals, Inc. All Rights Reserved SAGLB.IMM.17.05.0442d 07/17

8061_SGR_ESDR_Symposium_ProgramAd_07.indd 1 9/6/17 10:32 AM

— 12 —

PROGRAM

Wolf-Dietrich Hall

08.30-09.30

Mozart Hall 1-3

Galderma Symposium

IL 31: A Novel Key Pro-Inflammatory Cytokine

Mozart Hall 4-5

Biotest Symposium

Immunoglobulin Therapyin Severe Autoimmune

Skin Diseases

Nogra Pharma Symposium

PPAR gamma Modulation inthe Management of Pilose-

baceous Unit Disorders

09.35-10.05

(Switzerland)

10.05-11.30

11.30-12.25 Poster Viewing Poster Walks (odd numbers) & (01-10)

12.30-14.00

14.05-14.35

14.35-15.30 Poster Viewing Poster Walks (even numbers) & (11-20)

15.35-16.05

16.10-17.35

Janssen Symposium

Linking Pathophysiology toClinical Options in Psoriasis:

New Insights in to IL-23

Concurrent Session 5

Melanoma & Other SkinCancers

Chanel R&T Symposium

Well Ageing and Skin


Hair & Other AdnexalStructures

17.40-18.30

Europa Hall

Cel gene ESDRGuest Lecture

Federica Sallusto

Plenary 2

Frontiers in Skin Biology

Dermatology 2

Celgene Symposium

MHC-I-opathies:Understanding CommonImmunological Pathways

ESDR Guest Lecture

Matthias Mann (Germany)

René TouraineGuest Lecture

G. Paolo Dotto (Switzerland)


Genetics & Cell BasedTherapy

ESDR Annual GeneralMeeting of Members

19.30-24.00 Social Networking Event (Der Stieglkeller, Salzburg)

Friday, 29 September 2017

09.00-10.30

10.30-11.30 Poster Viewing Poster Walks (all authors) & (21-30)

11.35-12.05

12.10-13.4012.15-13.30 Epidermal

Homeostasis and Rare Disease

13.45-14.00

Europa Hall


Inflammation, Immunity & Infection 2

EADV Guest Lecture

Michael Hertl (Germany)

EADV/ESDRClinical Saturday Lectures

ESDR Poster Prizes

Closing Ceremony

14.00-17.00

Mozart Hall 1-3


Clinical Outcomes

Skin Epigenetics

Mozart Hall 4-5


Wound Healing & Tissue Remodelling

Innovationand Entrepreneurshipin Skin Science

Saturday, 30 September 2017

Mozart Hall1-3 Mozart Hall4-5 Wolf-Dietrich Hall

11.00-13.0011.00-18.45

European Epidermal BarrierResearch Network (E2BRM)

13.00-14.00 13.00-18.00

Future LeadersSymposium14.00-18.00 14.00-18.00 Dermatoendocrinology

14.00-18.00 Satellite Meetings Welcome Reception

Wednesday, 27 September2017

Mozart Hall1-3 Wolf-Dietrich Hall

08.30-10.30

Europa Hall

Drug Discoveryand Translational

Medicine

International EczemaCouncil Symposium

The Role of EnvironmentalFactors in AD

Mozart Hall4-5

EasternEuropeanResearch

EDEN

Papageno Hall

Neurobiologyof the Skin

10.30-11.00 Coffee Break

11.00-11.10 Opening Ceremony

11.15-12.45

Plenary1

Frontiers in SkinBiology

Dermatology1

12.45-13.15 12.45-14.15

The LEO PharmaResearch Foundation

Awards 2017

in associationwith the ESDR

13.15-14.15

Sanofi GenzymeSymposium

The EvolvingTreatment Landscapefor Atopic Dermatitis

14.20-15.45


Inflammation,Immunity

& Infection 1


Epidermal Structure& Function

Concurrent Session3

Photobiology& Pigmentation

15.50-16.20

Rudi CormaneLecture

Masayuki Amagai(Japan)

16.20-17.40 General Poster Viewing Session

17.45-17.55JSID and SIDIntersociety

Collegiality Awards

18.00-18.30

Special GuestLecture

Clemens Sedmak(Austria)

18.30 -18.45ESDR Honorary

MembershipAwards

18.45 - 21.00 Welcome Reception

Thursday, 28 September 2017

Parallel Session Sponsored Session

Concurrent SessionSocial Program

ESDR Session

Legend

Guest LecturePoster Session

PROGRAM AT GLANCE

Wednesday 27 September 2017

W W W.ESDR2017.ORGNotes

— 16 —

EUROPEAN EPIDERMAL BARRIER RESEARCH NETWORK (E2BRN)Date: Wednesday 27 September 2017Time: 11.00–18.45Room: Mozart Hall 4+5, Ground Floor

15th meeting of the European Epidermal Barrier Research Network

Session 2: Skin Stress responseChair: Sandra Simoes

14.00–14.25 Control of mechanism of DC‘s cell death induced by chemical sensitizers Saadia Kerdine-Römer (UMR-S 996, Faculté de Pharmacie, Université Paris-Sud, France)

14.25–14.50 Does stress help to brake the skin barrier? Eva Peters (Charité Universitaetsmedizin Berlin, Germany)

14.50–15.05 Characterization of TSG-6 protein in healthy and inflammatory models of reconstructed human epidermis Celine Evrard (URPhyM-NARILIS, University of Namur, Belgium)

15.05–15.20 Organic osmolytes protect keratinocyte tight junctions from the harmful effects of Ultraviolet Radiation Cecile el Chami (Faculty of Medical and Human Sciences, University of Manchester, UK)

15.20–15.35 Characterization of xenobiotic metabolizing enzymes of a reconstructed human epidermal model, as part of the metabolism skin barrier Daniel Bacqueville (Pierre Fabre Dermo-cosmétique, Toulouse, France)

15.35–17.00 Coffee and Posters

Session 3: Skin Barrier Homeostasis Chairs: Rosalind Hannen (UK), Guiseppe Percoco (France)

17.00- 17.25 Stressed out keratinocytes Rosalind Hannen (Queen Mary University of London Centre for Cell Biology and Cutaneous Research, Blizard Institute, UK)

17.25– 17.50 Persistent kallikrein5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity Wei-Li Di (University College London, UK)

17.50–18.05 MiR-30a is an aged-related microRNA that impairs differentiation and induces apoptosis in human epidermis Jerome Lamartine (LBTI UMR5305 CNRS/UCBLI, Lyon, France)

18.05–18.20 1-Deoxy-sphingosine, 3-Deoxy-sphingosine and N-Methyl-sphingosine Ceramides in Model Skin Membranes: Permeability and Biophysics Andrej Kováčik (Skin Barrier Research Group, Charles University, Faculty of Pharmacy in Hradec Králové, Czech Republic)

18.20–18.35 Normalization of the stratum corneum lipids by targeting the liver X receptor in Human Skin Equivalents R.J.W Helder (Drug delivery technology, LACDR Leiden University, The Netherlands)

18.35–18.45 Poster Prizes and Closing Remarks

WEDNESDAY11.00–11.05 Opening

Johanna M. Brandner (Hamburg, Germany)

Session 1: Mendelian genetic disease and skin barrier Chairs: Ryan O’Shaughnessy (UK), Florian Ehrlich (Austria)

11.05–11.30 One more step towards understanding sphingolipid metabolism and skin permeability barrier through the analysis of Pnpla1-deficient mice and PNPLA1-mutated patients suffering from Autosomal Recessive Congenital Ichthyosis (ARCI) Nathalie Jonca (INSERM U1056 - Toulouse III University, France)

11.30–11.45 Evidence for a palmoplantar-specific role for microtubules Helene Louis Dit Picard (Blizard Institute, Queen Mary University of London, UK)

11.45–12.00 In reconstructed human epidermis, peptidylarginine deiminase inhibitor Cl-amidine modulates cornification and keratinocyte autophagic flux Laura Cau (UDEAR, INSERM-University of Toulouse, France)

12.00–12.15 Mutations in three genes encoding proteins involved in hair shaft formation cause uncombable hair syndrome Buket Basmanav (Institute of Human Genetics, University of Bonn, Germany)

12.15–14.00 Lunch and Posters

Program

— 18 — — 19 —

WEDNESDAY

12.30–13.00 Registration

13.00–13.15 Welcome and introduction to Future Leaders Symposium ESDR: Matthew Caley / JSID: Hideyuki Ujiie / SID: Tamia A. Harris-Tryon

Session 1Chairs: Matthew Caley and Hayato Takahashi

13.15–13.45 Keynote speaker from the ESDR Palm reading the future: genetic skin disease and beyond David Kelsell (London, UK)

13.45–14.45 Scientific Presentations (15min + 5 min discussion)

SDR / Transcriptomic led drug targeting of inherited cylindromas: From bench to clinic without a mouse Neil Rajan (Newcastle, UK)

JSID / PSMα as a key virulence in Staphylococcus aureus-induced skin inflammation through IL-36 and IL-1 release from keratinocytesSeitaro Nakagawa (Chiba, Japan)

SID /From basic to translational science: Lessons from two collagens type VII and XVII in the skin Joanna Jackow (New York, USA)

14.45–15.30 Interactive session led by Amy Foulkes

Innate-like T cells in human skin: characterising the human lymphoid stress surveillance response Richard Woolf (London, UK)

Exploring the pathogenesis of alopecia areata Marta Bertolini (Münster, Germany)

Mechanisms of mast cells and T cell interactions during viral infections Melba Munoz Roldan (Berlin, Germany)

Light-independent pro-inflammatory and pro-oxidant effects of purified human hair melanins on keratinocyte cell culturesSerena Lembo (Salerno, Italy)

15.30–16.00 Keynote speaker from the JSID From Blisters via Bethesda to the Bulge – A Decade of Journey to Find my Own Niche Manabu Ohyama (Tokyo, Japan)


Session 2 Chairs: Amy Foulkes and Tamia A. Harris-Tryon

16.15–16.45 Special Guest Lecture Gitte Aabo (President and Chief Executive Officer, LEO Pharma)

16.45–17.00 2017 Women in Dermatological Research Fellow Reflections on the status of women in skin science Tamia Harris-Tryon (Dallas, USA)

17.00–17.20 Keynote speaker from the ESDR Mentoring and Leadership Chris Griffiths (Manchester, UK)

17.20–17.50 Keynote speaker from the SID It’s the data that matters – a personal perspective on academic investigative dermatology Andrew South (Philadelphia, USA)

17.50–18.00 Closing Remarks

18.00–19.00 Reception (all symposium delegates)

19.00 Future Leaders Dinner (for pre-registered delegates)

Program

— 20 — — 21 —

WEDNESDAY

WEDNESDAY2017 FUTURE LEADERS SYMPOSIUMDate: Wednesday 27 September 2017Time: 13.00–18.00Room: Mozart Hall 1+2+3, Ground FloorTheme: Looking Forward: The Future of Dermatological Research

Given great global social and political change, we consider the past, present and future trajectory of dermatology with implications for our future research practice. This session aims to facilitate interaction and collaboration between young ambitious researchers and current leaders in the field of investigative dermatology around the world.

The Future Leaders Symposium is open to all ESDR delegates, though pre-registration is preferred. Places at the Future Leaders dinner are limited and pre-registration is required.

Program Organizing CommitteeESDR: Amy Foulkes (Manchester, UK), Matthew Caley (London, UK)JSID: Hayato Takahashi (Tokyo, Japan), Hideyuki Ujiie (Sapporo, Japan)SID: Andrew South (Philadelphia, USA), Tamia A. Harris-Tryon (Dallas, USA)

This event is supported by unrestricted educational grants from the following:

14.00–14.05 Welcome & Introduction Thomas Luger (Münster, Germany)

14.10–14.37 Lecture 1 Psychoemotional stress responses of the skin: Lessons from hair, mice, and female students (20 min + 7 min discussion) Eva Peters (Berlin & Giessen, Germany)

14.37–15.04 Lecture 2 Substance P and calcitonin gene-related peptide: Key regulators of cutaneous microbiota homeostasis (20 min + 7 min discussion) Marc Feuilloley (Evreux, France)

15.04–15.18 Oral presentation from selected ESDR abstracts The role of corticotropin releasing hormone in connective tissue - and mucosal-type mast cell biology (10 min + 4 min discussion) Koji Sugawara (Osaka, Japan)

15.18–15.45 Lecture 3 Retinoids as modulators of skin inflammation and skin microbiome: Lessons from acne (20 min + 7 min discussion) Antti Lauerma (Helsinki, Finland)


16.15–16.45 Keynote Lecture Estrogen receptor ß as a pharmaceutical target in skin and hair research (20 min + 10 min discussion) Jan-Ake Gustafsson (Houston, TX & Huddinge, Sweden)

16.45–17.12 Lecture 5 Role of galanin in cutaneous biology (20 min + 7 min discussion) Barbara Kofler (Salzburg, Austria)

17.12–17.26 Oral presentation from selected ESDR abstracts Mineralocorticoid receptor: pathophysiology and therapeutic innovations (10 min + 4 min discussion) Tuan Nguyen (Paris, France)

17.26–17.53 Closing Lecture Is hidradenitis/acne inversa an endocrine disorder? (25 min + 9 min discussion) Christos Zouboulis (Dessau, Germany)

17.53–18.00 Closing Remarks

18.00–18.45 ESDR Reception for Satellite Meeting Attendees

WEDNESDAY

Program

Notes

— 22 — — 23 —

WEDNESDAY

5TH ESDR SATELLITE SYMPOSIUM DERMATOENDOCRINOLOGYDate: Wednesday 27 September 2017Time: 14.00–18.00Room: Wolf-Dietrich Hall, 1st floorTheme: Looking Forward: The Future of Dermatological ResearchOrganizers & Discussion: Ralf Paus (Manchester, UK) & Markus Böhm (Münster, Germany)

The satelite symposium is open to all ESDR 2017 registered delegates.

This satellite symposium is kindly supported by:

W W W.ESDR2017.ORGNotes

— 24 — — 25 —

Thursday 28 September 2017

THURSDAYDRUG DISCOVERY AND TRANSLATIONAL MEDICINEDate: Thursday 28 September 2017 Time: 08.30–10.30Room: Europa Hall, 2nd floorChairs: Matthias Schmuth, Michel Gilliet

This ESDR session is supported by educational grants from:

EASTERN EUROPEAN RESEARCHDate: Thursday 28 September 2017Time: 08.30–10.30Room: Mozart Hall 4+5, Ground FloorChairs: Johann Bauer, Marta Szell

This program is supported by grants from:

Program08.30–08.50 How to Bridge from Translational in vitro assays to in vivo Efficacy

Peter Florian (Director of Pharmacology, Sanofi, Frankfurt)

08.50–09.10 Animal Models: How to Test Protease Inhibitors in vivo Alain Hovnanian (Professor of Medical Genetics and Director of INSERM department (U781), Necker Enfants Malades Hospital, University Paris Descartes Sorbonne Cité, Paris)

09.10–09.30 Key Facts for Bench Scientists: Working with Regulators Before, During and After the Licensing Procedure Harald Tietz (Director Global Patient Safety and Regulatory Affairs, Eli Lilly, Bad Homburg)

09.30–09.50 Promising Areas of Academia-Industry Collaboration: A personal Perspective Ralf Paus (Professor of Cutaneous Medicine, Director of Research & Deputy Lead, Centre for Dermatology Research, University of Manchester)

09.50–10.30 Pros and Cons of Industry-Academia Collaborations Round table debate with Peter Florian, Alain Hovnanian, Ralf Paus, Anton Stuetz, Harald Tietz

Introduced by Anton Stuetz

08.30–08.40 Welcome notes and awards Academic Leader and Research Fellows

08.40–09.00 Academic Leader 2017: Investigations on psoriasis Zsuzsanna Bata-Csörgő (Szeged, Hungary)

09.00–09.10 Cannabinoid receptor 1 (CB1) is a novel negative regulator of keratinocyte mitochondrial function in human epidermis ex vivo Attila Oláh (Debrecen, Hungary)

09.10–09.20 Morphogenetic events in hair follicle heterotypic spheroids Ekaterina Kalabusheva (Moskow, Russia)

09.20–09.30 The functional characterization of CARD14 variants in pityriasis rubra pilaris affected skin and keratinocytes Anikó Göblös (Szeged, Hungary)

09.30–09.40 SERPINB2 is regulated by the NF-kB pathway and miR-146a in human primary keratinocytes and psoriasis Helen Hermann (Tartu, Estonia)

09.40–09.50 Effects of melanoma derived exosomes on peritumoral stromal cells Tünde Buknicz (Szeged, Hungary)

09.50–10.00 Poly(ADP-ribose) polymerase-1 activity modulates mitochondrial function following UVB irradiationCsaba Hegedűs (Debrecen, Hungary)

10.00–10.10 Molecular diagnostics of ichthyoses using genodermatoses-dedicated next generation sequencing panel in Polish patients Katarzyna Wertheim-Tysarowska (Warsaw, Poland)

10.10–10.20 Dual vibration resonance frequency CARS microscopy imaging of basal cell carcinoma to achieve stain free histopathology Norbert Kiss (Budapest, Hungary)

10.20–10.30 In memoriam Professor Stefania Jablonska Anna Zalewska (Lodz, Poland)

10.30 Closing Remarks2017 Research Fellow Awards go to:1. Piotr Konieczky (Poland) 2. Csaba Hegedűs (Hungary) 3. Ekaterina Kalabusheva (Russia) 4. Helen Hermann (Estonia)

Program

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THURSDAY

THURSDAYINTERNATIONAL ECZEMA COUNCIL SYMPOSIUMThe Role Of Environmental Factors In ADDate: Thursday 28 September 2017Time: 08.30–10.30Room: Mozart Hall 1+2+3, Ground FloorChairs: Sara J Brown (Dundee, UK), Thomas Werfel (Hannover, Germany)

This program is sponsored by:

EUROPEAN DERMATO-EPIDEMIOLOGY NETWORKDate: Thursday 28 September 2017Time: 08.30–10.30Room: Wolf-Dietrich Hall, 1st floorChairs: Jan Nico Bouwes Bavinck, Marlies Wakkee

08.30–08.40 Welcome IEC and Program Overview Sara Brown (Dundee, UK)

08.40–09.05 Gene-environment Interactions in the Pathogenesis of Atopic Eczema Sara Brown (Dundee, UK)

09.05–09.30 Air pollution and eczema in the elderly: Findings from the SALIA cohort Jean Krutmann (Düsseldorf, Germany)

09.30–09.55 Antigens/Allergic Triggers and Environment Thomas Werfel (Hannover, Germany)

09.55–10.20 Microbiome Claudia Traidl-Hoffmann (Munich, Germany)

10.20–10.30 Closing Comments Thomas Werfel (Hannover, Germany)

Program

08.30-08.50

KEYNOTE LECTURE Skin cancer epidemiology: Possibilities and pitfalls of routine data Marlies Wakkee (Rotterdam, The Netherlands)

08.50–09.00

(Poster 041) Prevalence, characteristics and burden of pruritus in chronic dermatoses Tomasz Hawro (Berlin, Germany)

09.00-09.10

(Poster 604) Increased risk for vulvar melanoma among patients with lichen sclerosis Niina Hieta (Turku, Finland)

09.10–09.20

(Poster 571) The readability of online patient resources for skin cancer treatment Thomas Dobb (Swansea, United Kingdom)

09.20–09.30

(Poster 006) Abdominal obesity and insulin resistance are strongly associated with liver fibrosis in people with severe psoriasis Catriona Maybury (London, United Kingdom)

09.30–09.40

(Poster 001) Risk of serious infection associated with biologic therapies in psoriasis : a prospective cohort study from the British Association of Dermatologists Biologic Interventions Register (BADBIR) Zenas Yiu (Manchester, United Kingdom)

09.40–09.50

(Poster 037) Safety of systemic psoriasis treatments evaluated in the Swiss Dermatology Network for Targeted Therapies (SDNTT) Julia-Tatjana Maul (Zürich, Switzerland)

09.50–10.00

(Poster 020) Responsiveness, Minimal Clinically Important Difference (MCID), and cut-offs for the Pemphigus Disease Area Index (PDAI) and Autoimmune Bullous Skin disorder Intensity Score (ABSIS) for Pemphigus Sarah Hanna (Sydney, Australia)

10.00–10.10

(Poster 579) High-risk human papillomavirus infection in Bowen‘s disease and squamous cell carcinomas of the hands Sonja Dorfer (Vienna, Austria)

10.10–10.30

Keynote Lecture Human papillomavirus infection and cutaneous squamous-cell carcinoma Jan Nico Bouwes Bavinck (Leiden, The Netherlands)

Program

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THURSDAY

THURSDAYNEUROBIOLOGY OF THE SKINDate: Thursday 28 September 2017Time: 08.30–10.30Room: Papageno HallChairs: Anna Zalewska (Lodz, Poland) & Marcus Maurer (Berlin, Germany)

PLENARY 1 & FRONTIERS IN SKIN BIOLOGY AND DERMATOLOGY 1Date: Thursday 28 September 2017Time: 11.15–12.45Room: Europa Hall, 2nd floorChairs: Juha Kere, Matthias Schmuth, Maria Sibilia

The Frontiers in Skin Biology and Dermatology Lectures in this session are supported by:

08.30-08.35 Welcome and Introduction Anna Zalewska (Lodz, Poland)

08.35-08.53 Neurogenic Inflammation in Skin Diseases: Focus on Nervous System and Adaptive Immune Response Interactions Luis F. Santamaria-Babi (Barcelona, Spain)

08.53-09.11 Neuropathic Pain in Skin Laurent Misery (Brest, France)

09.11-09.29 Mapping The “Brain-Skin” Axis Elise Kleyn (Manchester, UK)

09.29-09.47 Psoriasis and Alcohol and Neurotransmitters Klas Nordlind (Stockholm, Sweden)

09.47-10.05 Role of Adaptive and Innate System in Chronic Itch Martin Steinhoff (Dubin, Ireland)

10.05-10.23 Chronic Itch – Impact and Insights Tomasz Hawro (Berlin, Germany)

10.23-10.30 Closing Remarks Marcus Maurer (Berlin, Germany)

Program

11:00–11:15 Opening Ceremony

11.15–11.40 Frontiers in Skin Biology and Dermatology Lecture

Keratinocyte Transcriptomics from Skin Biopsies to Single Cells Juha Kere (Huddinge, Sweden)

Plenary Presentations

11.40–11.50 001 (Poster 292) Regulatory T cell is essential for deletion of autoreactive CD4+ T cells to desmoglein 3 in peripheral tolerance H Iriki,1,2 H Takahashi,1,2 N Wada1 and M Amagai1,2 1 Dermatology, Keio University School of Medicine, Tokyo, Japan and 2 Laboratory for Skin Homeostasis, RIKEN IMS, Yokohama, Japan

11.50–12.00 002 (Poster 088) Understanding the role of ABCA12 in the Pathogenesis of Harlequin Ichthyosis F Enjalbert,1 P Dewan,1 M Caley,1 B Fell,1 M Morse,3 DP Kelsell,1 A Enright2 and EA O’Toole1 1 Cell Biology Cutaneous Research, QMUL, London, United Kingdom, 2 Wellcome Trust Genome Campus, EMBL, Hinxton, Cambridge, United Kingdom and 3 ImmunoInflammation Therapy Area, GSK, Stevenage, United Kingdom

12.00–12.10 003 (Poster 310) Unopposed IL-36 activity promotes clonal CD4+ T-cell responses with IL-17A production in generalized pustular psoriasis A Arakawa, S Vollmer, P Besgen, B Summer, T Ruzicka, P Thomas and JC Prinz Dermatology, LMU, Germany, Germany

12.10–12.20 004 (Poster 658) Wound Healing and Tissue Remodelling Low-dose CCL2 allows the rescue of maternal delayed healing through fetal progenitor cells recruitment M Castela,1 M Sbeih,1 D Nassar,1 M Jachiet,1 Z Wang1 and S Aractingi2 1 Centre de Recherche Saint-Antoine-INSERM UMRS_938, Paris, France and 2 Faculté de médecine Paris 5 Descartes, Paris, France

12.20–12.45 Frontiers in Skin Biology and Dermatology Lecture Cell-Specific Functions of Epidermal Growth Factor Receptor (EGFR) Signaling in Inflammation and Cancer Maria Sibilia (Vienna, Austria)

Program

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THURSDAY

THURSDAYLEO PHARMA RESEARCH FOUNDATION AWARDS & SYMPOSIUMDate: Thursday 28 September 2017Time: 12.45–14.15Room: Europa Hall, 2nd floor

Program12.45–12.50 Introduction to the award ceremony

Mads Røpke (Member of LEO Pharma Research Foundation Award Committee)

12.50–13.00 Introduction to the award winners and presentation of the awards Matthias Schmuth (President of the ESDR)

13.00–13.25 Gold Award winner Niche signaling and molecular adjustments during skin regeneration Maria Kasper (Huddinge, Sweden)

13.25–13.50 Silver Award winner Th9 & Th2 cells: Same same, but different Christoph Schlapbach (Bern, Switzerland)

13.50–14.15 Keynote lecture Bypassing senescence during melanomagenesis Lionel Larue (Paris, France)

THE EVOLVING TREATMENT LANDSCAPE FOR ATOPIC DERMATITISDate: Thursday 28 September 2017Time: 13.15–14.15Room: Mozart Hall 1+ 2+3, Ground FloorChair: Georg Stingl (Vienna, Austria)

13.15–13.35 Welcome and IntroductionClinical Challenges and Future Directions in the Treatment of Atopic Dermatitis Georg Stingl (Vienna, Austria)

13.35–13.55 Targeting Pathways Involved in the Pathophysiology of Atopic Dermatitis Marjolein de Bruin-Weller (Utrecht, The Netherlands)

13.55–14.15 Translating Scientific Advances Into the Atopic Dermatitis Treatment Paradigm Tilo Biedermann (Munich, Germany)

Program

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THURSDAY

THURSDAYCONCURRENT SESSION 1: INFLAMMATION, IMMUNITY & INFECTION 1Date: Thursday 28 September 2017Time: 14.20–15.45Room: Europa Hall, 2nd floorChairs: Sandrine Dubrac, Olivier Gaide

Program14.20–14.30 011 (Poster 294) IL-17RA and not IL-17RE

is required for IL-17C-mediated psoriasiform inflammation S Sigurdardottir, Y Fritz, P Klenotic and NL Ward Dermatology, Case Western Reserve University, Cleveland, USA

14.30–14.40 012 (Poster 312) A Key Signaling Molecule for the Establishment of Inflammatory Loop of IL-17 in the Skin Identified in Keratinocytes R Matsumoto, T Dainichi, K Sakurai, Y Nakano, M Otsuka, T Nomura and K Kabashima Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan

14.40–14.50 013 (Poster 311) Group 3 innate lymphoid cells (ILC3) induce psoriasiform lesions in human skin xenotransplants in vivo A Keren1, A Shemer1, A Ginzburg1, Y Ullmann1, R Paus2, A Gilhar1 1Technion, Israel, 2Centre for Dermatology Research Centre, University of Manchester, UK

14.50–15.00 014 (Poster 313) IL-17A–producing type 3 innate lymphoid cells derive from type 2 innate lymphoid cells M Teunissen,2 XR Ros,1 S van Tol,1 L Krabbendam,1 M De Rie,2 H Spits1 and JH Bernink1 1Cell Biology and Histology, Academic Medical Center, Amsterdam, Netherlands and 2Dermatology, Academic Medical Center, Amsterdam, Netherlands

15.00–15.10 015 (Poster 301) The psoriasis-associated IL-17A induces and cooperates with IL-36 cytokines to control keratinocyte differentiation and function CM Pfaff, D Kluwig, Y Marquardt, K Fietkau, B Lüscher and JM Baron Uniklinik RWTH Aachen, Aachen, Germany

15.10–15.20 016 (Poster 300) Tonicity signals drive immunoparalysis and anti-inflammatory Th17 cell properties J Matthias and C Zielinski TU Munich, Munich, Germany

15.20–15.30 017 (Poster 363) The differential production of IL-26 vs. IL-17 by Th17 cells contributes to the development of different forms of psoriasis J Di Domizio, A Fries, O Demaria and M Gilliet Dermatology, University Hospital Lausanne, Lausanne, Switzerland

15.30–15.40 018 (Poster 307) Identification of resolvin E1, an omega-3 poly-unsaturated fatty acids-derived lipid mediator, as an inhibitor for psoriatic dermatitis by downregulating migration of IL-17A-producing cutaneous γδ T cells and IL-23 production from dendritic cells T Honda, Y Sawada and K Kabashima Kyoto University, Kyoto, Japan

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CONCURRENT SESSION 2: EPIDERMAL STRUCTURE & FUNCTIONDate: Thursday 28 September 2017Time: 14.20–15.45Room: Mozart Hall 1+2+3, Ground FloorChairs: Johanna Brandner, Sara Brown

Program14.20–14.30 019 (Poster 090) The N -terminal domain of Filaggrin 2 co-localizes, binds

to and activates the Skin aspartic acid protease in the epidermis of human skin M Donovan,1 A Thomas-Collignon,2 L Simonetti,1 S Desbouis,1 C Collin-Djangoné, C Reverdy,3 J Rain,3 E Formstecher3 and D Bernard1 1 L’Oréal R&I, Aulnay sous Bois, France, 2 CNRS, Gif sur Yvette, France and 3 Hybrigenics Services, Paris, France

14.30–14.40 020 (Poster 084) The keratin cytoskeleton as a regulator of keratinocyte mechano-sensing A Laly and J Connelly Centre for Cell Biology and Cutaneous Research, Blizard Institute – Barts and The London School of Medicine and Dentistry, London, United Kingdom

14.40–14.50 021 (Poster 097) iRHOM2 regulation of loricrin in the epidermal barrier L McGinty, DP Kelsell and D Blaydon Centre for Cell Biology and Cutaneous Research, Queen Mary University of London, London, United Kingdom

14.50–15.00 022 (Poster 085) Type XVII collagen suppresses interfollicular epidermal proliferation in neonatal and aged skin, and helps rejuvenate epidermis M Watanabe,1 K Natsuga,1 W Nishie,1 G Donati,4 Y Fujimura,1 T Tsukiyama,2 H Ujiie,1 M Ozaki,3 FM Watt4 and H Shimizu1 1 Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2 Department of Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 3Department of Biological Response and Regulation, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan and 4 Centre for Stem Cells and Regenerative Medicine, King’s College London, London, United Kingdom

15.00–15.10 023 (Poster 092) BNIP3-induced autophagy is required for maintenance of epidermal homeostasis M Moriyama, H Kubo, T Morita, T Hayakawa and H Moriyama Pharmaceutical Research and Technology Institute, Kindai University, Higashi-Osaka, Japan

15.10–15.20 024 (Poster 079) Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis H Fischer, M Buchberger, E Tschachler and L Eckhart Department of Dermatology, Medical University of Vienna, Vienna, Austria

15.20–15.30 025 (Poster 076) Chromatin architectural protein CTCF controls terminal keratinocyte differentiation, epidermal barrier maintenance and suppresses inflammatory responses in the skin I Malashchuk,1 J Rudolf,1 T Vafaee,1 K Poterlowicz,1 A Sharov,2 MY Fessing,1 AN Mardaryev1 and V Botchkarev1,2 1 Centre for Skin Sciences, University of Bradford, Bradford, United Kingdom and 2 Department of Dermatology, Boston University, Boston, MA

15.30–15.40 026 (Poster 091) 5C analysis reveals distinct spatial contact networks between gene-rich and gene-poor TADs at the Epidermal Differentiation Complex in skin epithelial cells K Poterlowicz,1 J Yarker,1 I Malashchuk,1 AN Mardaryev,1 MR Gdula,2 A Sharov,3 T Kohwi-Shigematsu,4 V Botchkarev1 and MY Fessing11 University of Bradford, Bradford, United Kingdom, 2 Biochemistry, University of Oxford, Oxford, United Kingdom, 3 Boston University School of Medicine, Biston, MA and 4 University of California San Francisco, San Francisco, CA

THURSDAY

THURSDAYCONCURRENT SESSION 3: PHOTOBIOLOGY & PIGMENTATIONDate: Thursday 28 September 2017Time: 14.20–15.45Room: Mozart Hall 4+5, Ground FloorChairs: York Kamenisch, Thierry Passeron

Program14.20–14.30 027 (Poster 624) Autophagy Alleviates UVA-Induced DNA Damage in Fibrocyte

by Activating the Nrf2-dependent Nucleotide Excision Repair Pathway Y He, X Tan, J He, Y Deng and X Xiong Dermatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China

14.30–14.40 028 (Poster 625) Development of an ex vivo Human Skin Model to Study the Effects of Ambient Relevant Air Pollutants Reveals Epidermal Activation of the Arylhydrocarbon Receptor S Grether-Beck,1 I Meyer,2 H Brenden,1 I Felsner1 and J Krutmann1 1 IUF–Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany and 2Symrise AG, Holzminden, Germany

14.40–14.50 029 (Poster 616) Postzygotic mutations of RHOA cause a mosaic neuroectodermal syndrome P Vabres,1 A Sorlin,1 SS Kholmanskikh,2 B Demeer,3 J St-Onge,1,4 Y Duffourd,1 P Kuentz,1,5 J Courcet,1 V Carmignac,1 D Bessis,6 G Bernard,4 WB Dobyns,7 L Faivre,1M Ross2 and J Rivière1,4 1 TRANSLAD UMR1231 UBFC, Dijon, France, 2 FFBMRI, New York, NY, 3 CHU, Amiens, France, 4 McGill University, Montreal, QC, Canada, 5CHRU, Besançon, France, 6 CHRU, Montpellier, France and 7 SCRI, Seattle, WA

14.50–15.00 030 (Poster 617) Cole disease: Role of ENPP1 in regulation of pigmentation and epidermal differentiation S Nesmond,1 R Bochner,4 O Sarig,4 C Pain,1,2 V Bergeron,1,2 J Rambert,5 F Morice-Picard,3 E Sprecher,4 A Taieb1,2,3 and M Cario-Andre1,2,3 1 INSERM 1035, Bordeaux, France, 2 University Bordeaux, Bordeaux, France, 3 National reference center for rare skin diseases, Bordeaux, France, 4 Dermatology, Sourasky Medical Center, Tel Avis, Israel and 5 Aquiderm, Bordeaux, France

15.00–15.10 031 (Poster 619) Prostaglandins contribute to specific ultraviolet irradiation-induced molecular alterations that are critically involved in photoaging process P Wang, M Sun, T Okubo, JJ Voorhees, GJ Fisher and Y Li Dermatology, University of Michigan, Ann Arbor, USA

15.10–15.20 032 (Poster 626) Melanocyte-fibroblast interactions in vitiligo D Kovacs,1 E Bastonini,1 M Ottaviani,1 C Cota,2 E Migliano,3 M Dell’Anna1 and M Picardo1 1 Cutaneous Physiopathology/CIRM, San Gallicano Dermatologic Institute, Rome, Italy, 2 Dermatopathological Laboratory, San Gallicano Dermatologic Institute, Rome, Italy and 3 Department of Plastic and Reconstructive Surgery, San Gallicano Dermatologic Institute, Rome, Italy

15.20–15.30 033 (Poster 618) Asymmetric melanin distribution during the mitosis of human skin progenitor keratinocytes N Joly-Tonetti,1,2 JI Wibawa,3 M Bell3 and D Tobin1 1 Centre for Skin Sciences, University of Bradford, Bradford, United Kingdom, 2Alphenyx, Marseille France, France and 3 Walgreens Boots Alliance, Nottingham, United Kingdom

15.30–15.40 034 (Poster 615) Inhibition of NADPH oxidase-1 as a new approach for the prevention and treatment of cutaneous squamous cell carcinoma H Raad,1,2 M Serrano-Sanchez1,2 and H Rezvani1,2 1 Bordeaux Univ, Bordeaux, France and 2 INSERM U1035, Bordeaux, France

MASAYUKI AMAGAI Vice Dean, Keio University School of Medicine. Professor and Chair, Department of Dermatology, Keio University School of Medicine, Tokyo

Date: Thursday 28 September 2017Time: 15.50–16.20Room: Europa Hall, 2nd floorLecture Title: Cracking the Codes of Autoimmune and Allergic Skin DiseasesIntroduced by: Jonathan Baker

Dr Masayuki Amagai’s clinical and research interests center on autoimmune and allergic skin diseases, skin barrier, and skin immunology. Specifically, he has been studying the pathophysiological mechanisms of pemphigus, the skin barrier and the homeostasis of stratum corneum and tight junctions, the impact of impaired skin barrier on skin microbiota and the onset of atopic dermatitis and other allergic disorders.

CLEMENS SEDMAK F.D. Maurice Chair: Professor for Social Ethics (Moral and Social Theology), King’s College London F.M. Schmölz Visiting Professor for Social Ethics at the Theological Faculty, University of Salzburg

Date: Thursday 28 September 2017Time: 18.00–18.30Room: Europa Hall, 2nd floorLecture Title: On Conflicts: Whose Interests, Which Goods?Introduced by: Johann Bauer

Research Interests: Social ethics with a special emphasis on poverty research, theories of justice and aspects of social exclusion, having coordinated an interdisciplinary research group on „option for the poor“ at the University of Salzburg Epistemology with a special focus on the relation between ethics and epistemology Philosophy of religion and religious studies, with a special interest in the social dimensions of religion and epistemological questions of religion

2017 Rudi Cormane Lecture 2017 Special Guest Lecture

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THURSDAY

W W W.ESDR2017.ORG

Friday 29 September 2017

Notes

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FRIDAY FRIDAYIMMUNOGLOBULIN THERAPY IN SEVERE AUTOIMMUNE SKIN DISEASESDate: Friday 28 September 2017Time: 08.30–09.30Room: Mozart Hall 4+5, Ground FloorChair: Alexander Enk (Heidelberg, Germany)

Program08.30–08.50 IVIG – why they are so valuable in severe autoimmune dermatoses?

Alexander Enk (Heidelberg, Germany)

08.50–09.10 Stevens-Johnson syndrome and toxic epidermal necrolysis – update on pathogenesis, clinical course and therapy Lars E. French (Zurich, Switzerland)

09.10–09.30 Non-receptor-mediated anti-inflammatory effects of IgG Ralf Ludwig (Lübeck, Germany)

IL-31: A NOVEL KEY PRO-INFLAMMATORY CYTOKINEDate: Friday 29 September 2017Time: 08.30–09.30Room: Mozart Hall 1+2+3, Ground FloorChairs: Thomas Ruzicka (Munich, Germany), Martin Steinhoff (Dublin, Ireland)

Program08.30–08.35 Welcome

Thomas Ruzicka (Munich, Germany)

08.35–08.50 Biology of IL-31 and IL-31 Receptor Bernhard Homey (Düsseldorf, Germany)

08.50–09.10 IL-31 in Atopic Dermatitis – Nemolizumab Results Andreas Wollenberg (Munich, Germany)

09.10–09.25 Involvement of IL-31 in other Skin Conditions Martin Steinhoff (Dublin, Ireland)

09.25–09.30 Conclusions and Closing Martin Steinhoff (Dublin, Ireland)

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FRIDAY

FRIDAY FRIDAYPPAR GAMMA MODULATION IN THE MANAGEMENT OF PILOSEBACEOUS UNIT DISORDERSDate: Friday 29 September 2017Time: 08.30–10.30Room: Wolf-Dietrich Hall, 1st floorChairs: Michel Gilliet (Lausanne), Mauro Picardo (Rome)

Program08.30–08.45 Introduction by Michel Gilliet

The role of PPAR gamma in the biology of the pilosebaceous unitC. Zouboulis (Berlin)

08.45–09.00 Roles of PPAR gamma modulation in the sebocyte functionsEmanuela Camera (Rome)

09.00–09.15 Exploiting PPAR gamma modulation in the treatment of acneMauro Picardo (Rome)

09.15–09.30 PPAR gamma signaling in human hair follicle biology and pathologyRalf Paus (Manchester)

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FRIDAY

FEDERICA SALLUSTOGroup Leader, Institute for Research in Biomedicine, USI Bellinzona, Switzerland

Date: Friday 29 September 2017Time: 9.35–10.05Room: Europa Hall, 2nd floorLecture Title: T cell Differentiation, Migration and Immune RegulationIntroduced by: Michel Gilliet

Federica Sallusto received the degree of Doctor in Biology from the University of Rome in 1988, and performed postdoctoral work at the Istituto Superiore di Sanità in Rome and at the Basel Institute for Immunology, where she was a member from 11/1996 to 4/2000. She is currently Group leader of the Cellular Immunology Laboratory and Director of the Center of Medical Immunology at the Institute for Research in Biomedicine, Università della Svizzera italiana, in Bellinzona, and since February 2017 Professor of Medical Immunology at the ETH Zurich. Her studies in the human system revealed a differential expression of chemokine receptors in Th1 and Th2 cells and led to the characterization of “central memory” and “effector memory” T cells as memory subsets with distinct migratory capacity and effector function. Among her recent contributions are the discovery of Th22 cells as a distinct subset of skin-homing T cells, the identification of markers to identify human Th17 cells and the characterization of two distinct types of pathogen-specific Th17 cells with pro-inflammatory and regulatory properties. Her recent work demonstrated that the T cell response induced by pathogens or vaccines comprise not only clones polarized toward a single fate, but also clones whose progeny have acquired multiple fates, providing evidence of intraclonal functional heterogeneity in vivo. She also developed a high-throughput cellular screening method based on libraries of polyclonally expanded T cells and used this method to show that human T cells specific for Mycobacterium tuberculosis are largely contained in a non-conventional Th1 subset and to dissect the T cell response in Dengue and Zika infected individuals. She received the Pharmacia Allergy Research Foundation Award in 1999, the Behring Lecture Prize in 2009 and was elected member of the German Academy of Science Leopoldina in 2009 and of EMBO in 2011. In 2013–2015 she was President of the Swiss Society for Allergology and Immunology.

2017 Celgene ESDR Guest Lecture

FRIDAY FRIDAYProgram

12.30–12.40 Opening Statement Hervé Bachelez (France)

12.40–13.00 MHC-I-opathies: A Rheumatology Approach Dennis McGonagle (UK)

13.00–13.20 MHC-I-opathies: A Dermatology Approach Jonathan Barker (UK)

13.20–13.45 Panel discussion / Audience Q&A

13.45–14.00 Closing Statement Hervé Bachelez (France)

MHC-I-OPATHIES: UNDERSTANDING COMMON IMMUNOLOGICAL PATHWAYSDate: Friday 29 September 2017Time: 12.30–14.00Room: Europa Hall, 2nd floorChair: Hervé Bachelez (France)

PLENARY 2 & FRONTIERS IN SKIN BIOLOGY AND DERMATOLOGY 2Date: Friday 29 September 2017Time: 10.05–11.30Room: Europa Hall, 2nd floorChairs: Matthew Caley, Amy Foulkes, Sara Wickström

10.05–10.30 Frontiers in Skin Biology and Dermatology Lecture Biomechanical Regulation of Epidermal Stem Cell Fate Sara Wickström (Cologne, Germany)

Plenary Presentations

10.30–10.40 005 (Poster 523) Reprogramming of energy metabolism during UVB-induced carcinogenesis M Hosseini,2,1 R Rossignol1,3 and H Rezvani2,1 1 Bordeaux Univ, BORDEAUX, France, 2 INSERM U1035, Bordeaux, France and 3 Inserm 1211, Bordeaux, France

10.40–10.50 006 (Poster 524) Regional variation in epidermal susceptibility to ultraviolet induced carcinogenesis reflects proliferative activity of epidermal progenitors E Roy, H Wong, V Murigneux, L Fink and K Khosrotehrani UQ Diamantina Institute,Translational Research Institute, University of Queensland, Brisbane, QLD, Australia

10.50–11.00 007 (Poster 303) The adaptive response of mesenchymal stem cells to danger signals regulate neutrophil activation in cutaneous wounds S Munir, K Singh, A BASU and K Scharffetter-Kochanek Dermatology and Allergic Diseases, Ulm University, Ulm, Germany

11.00–11.10 008 (Poster 083) iRHOM2-p63 pathway mediates survival and redox balance in keratinocytes P Arcidiacono, CM Webb, D Blaydon, A Chikh and DP Kelsell Centre for Cell Biology & Cutaneous Research, Blizard Institute Queen Mary University, London, United Kingdom

11.10–11.20 009 (Poster 309) A novel adipokine C1q/TNF-related proteins-3 decreases in psoriasis patients and ameliorates imiquimod-induced psoriasis-like skin lesions by inhibiting the proliferation and inflammatory cytokines expression of keratinocytes K Xue and G Wang Dermatology, Xijing Hospital, Xi’an, China

11.20–11.30 010 (Poster 087) Metabolic and stress kinase signaling control skin barrier function: implications for diabetic skin complications E Wachsmuth,1 M Awazawa,2 S Aghdam,1 F Tellkamp,1 M Pasparakis,3 J Brüning2 and CM Niessen1 1 Dermatology, University Hospital Cologne, Cologne, Germany, 2 University of Cologne, Center for Endocrinology, Diabetes and Preventive Medicine, Cologne, Germany and 3 Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany

Program

Notes

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FRIDAY

FRIDAY FRIDAYLINKING PATHOPHYSIOLOGY TO CLINICAL OPTIONS IN PSORIASIS: NEW INSIGHTS INTO IL-23Date: Friday 29 September 2017Time: 12.30–14.00Location: Mozart Hall 1+2+3, Ground Floor

Chairs: Antonio Costanzo, Humanitas Clinical Research Center, Milan, Italy (Scientific Committee and Chair)Carle Paul, Sabatier University, Toulouse, France (Scientific Committee)Flavio Caprioli, University of Milan, Italy

Program13.00–13.10 Welcome and introduction

Antonio Costanzo

13.10–13.30 The autoimmune story of psoriasis: A focus on autoantigens and cytokines Antonio Costanzo

13.30–13.55 Lessons from IL-23 in immune-mediated inflammatory diseases Flavio Caprioli

13.55–14.20 Linking pathophysiology and clinical evidence Carle Paul

14.20–14.30 Interactive Q&A and discussion Antonio Costanzo and Carle Paul

With the support of Janssen Pharmaceutical Companies of Johnson & Johnson in EMEA.

WELL AGEING & SKINDate: Friday 29 September 2017Time: 12.30–14.00Room: Mozart Hall 4+5, Ground Floor

Program12.30-12.40 Introduction

Christian Mahé (Paris, France)

12.40-13.00 Skin ageing phenotype Frédérique Morizot (Paris, France)

13.00-13.20 GWAS & skin ageing Irina Berlin (Paris, France)

13.20-13.40 Cellular senescence & ageing Johannes Grillari (Vienna, Austria)

13.45-14.00 Awards Ceremony Presented to David P. Kelsell (London, UK) Christian Mahé (Paris, France)

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FRIDAY

FRIDAY FRIDAYCONCURRENT SESSION 4: GENETICS & CELL BASED THERAPYDate: Friday 29 September 2017Time: 16.10–17.35Room: Europa Hall, 2nd floorChairs: Ryan O‘Shaughnessy, Verena Wally

Program16.10–16.20 035 (Poster 180) Decorin Increases Survival

and Ameliorates Disease Phenotype of Col7a1 Hypomorphic Mice F Cianfarani,1 A Nystroem,2 V Mittapalli,2 S Mastroeni,3 D Abeni,3 L Bruckner-Tuderman,2 G Zambruno,4 D Castiglia1 and T Odorisio1 1 Laboratory of Molecular and Cell biology, IDI-IRCCS, Rome, Italy, 2 Dermatology, University of Freiburg, Freiburg, Germany, 3 Clinical Epidemiology Unit, IDI-IRCCS, Rome, Italy and 4Dermatology Unit, Bambino Gesù Children’s Hospital-IRCCS, Rome, Italy

16.20–16.30 036 (Poster 179) Systemic administration of HMGB1 peptide drastically improves survival of the RDEB model mice by mobilizing multipotent stem/progenitor cells from bone marrow K Tamai,1,2 S Yamazaki,1,3 X Wang,1,3 M Nishida,1,3 T Shimbo,1 Y Kikuchi,1 L Bruckner-Tuderman,4 J Uitto,5 I Katayama2 and Y Kaneda3 1 Stem Cell Therapy Science, Osaka University, Suita, Japan, 2 Dermatology, Osaka University, Suita, Japan, 3 Genomix, Ibaraki, Japan, 4 Dermatology, University of Freiburg, Freiburg, Germany and 5 Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, USA

16.30–16.40 037 (Poster 177) VPS33B mutations cause ARKID syndrome affecting Rab protein interaction, collagen modification and epidermal structure R Gruber,1 C Rogerson,2 C Windpassinger,3 R Strohal,5 M Schmuth,1 P Kroisel,3 AR Janecke4 and P Gissen2,6 1 Department of Dermatology, Venereology and Allergy, Medical University of Innsbruck, Innsbruck, Austria, 2 MRC Laboratory for Molecular Cell Biology, University College London, London, United Kingdom, 3 Institute of Human Genetics, Medical University of Graz, Graz, Austria, 4 Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria, 5 Department of Dermatology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria and 6 Institute of Child Health, University College London, London, United Kingdom

16.40–16.50 038 (Poster 195) The identification of a postzygotic GJA1 mutation in a patient with an inflammatory linear verrucous epidermal nevus suggests that the disease is a mosaic of erythrokeratodermia variabilis et progressiva N Umegaki-Arao,1 T Sasaki,1,2 H Fujita,1 S Aoki,1 M Amagai,1 M Seishima3 and A Kubo1 1 Dermatology, Keio University School of Medicine, Tokyo, Japan, 2 Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan and 3 Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan

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FRIDAY

MATTHIAS MANNDirector, Department of Proteomics and Signal Transduction Max-Planck Institute of Biochemistry, Martinsried

Date: Friday 29 September 2017Time: 14.05–14.35Room: Europa Hall, 2nd floorLecture Title: Advanced Proteomics Technologies and their Application to BiomedicineIntroduced by: Nikolaus Romani

Professor Matthias Mann has contributed breakthroughs that have revolutionised proteomics techniques in biomedical laboratories around the world. His contributions include the “peptide sequence tag” approach which allows proteins to be computationally identified by the fragment spectra; nanoelectrospray which allows minute quantities of protein to be tested; and methods for analysing proteins after extracting them from gels.

Since 2005 he has been Director of the Department of Proteomics and Signal Transduction at the Max Planck Institute for Biochemistry in Munich where his group develops and applies methods of mass spectrometry (MS)-based proteomics in a variety of biological areas.

He is also Program Director at the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen where his Clinical Proteomics group conentrates on large scale analysis of human plasma proteomes.

2017 ESDR Guest LectureGIAN-PAOLO DOTTOFull Professor, Dept of Biochemistry, University of Lausanne

Date: Friday 29 September 2017Time: 15.35–16.05Room: Europa Hall, 2nd floorLecture Title: Genetic and Epigenetic Basis of Cancer Stromal Cell Evolution and Field CancerizationIntroduced by: Erwin Tschachler

Dr. Gian-Paolo Dotto received his MD from the University of Turin, Italy, in 1979, and his PhD in Genetics from the Rockefeller University, New York, in 1983. After postdoctoral training with Robert A. Weinberg at the Whitehead Institute/MIT in Cambridge, Mass., in 1987 Dr. Dotto joined Yale University, New Haven, Connecticut, as assistant professor of Pathology. In 1992 he was promoted to the rank of associate professor and soon after moved to Harvard Medical School, as associate professor of Dermatology in the newly established Cutaneous Biology Research Center. In 2000 he was promoted to the rank of Professor at Harvard Medical School and Biologist at Massachusetts General Hospital. In 2002 he accepted a position of Professor in the Department of Biochemistry at the University of Lausanne, while retaining his position of Biologist at Massachusetts General Hospital. He has been elected to the European Molecular Biology Organization (2011), the Academia Europaea (2012) and the Leopoldina German National Academy of Sciences (2014). He is the recipient of a number of awards, including the American Skin Association Achievement Award (2012) and an ERC Advanced investigator grant award (2013).

René Touraine Lecture

FRIDAY FRIDAYFRIDAY

Program16.10–16.20 043 (Poster 533) PDE4D is a therapeutic target in melanoma

N Dumaz,1,2 D Julie,1,2,3 S Becherirat,1,2 J Andre1,2 and C Lebbe1,2,3 1 INSERM U976, Paris, France, 2 UMRS 976, University Paris Diderot, Paris, France and 3Dermatology Department, Saint Louis Hospital, Paris, France

16.20–16.30 044 (Poster 532) Variable but distinct metabolic signature in malignant melanoma R Lang,1 RG Feichtinger,5 R Geilberger,5 F Rathje,5 JA Mayr,2 W Sperl,2 JW Bauer,1 C Hauser-Kronberger,3 M Emberger4 and B Kofler5 1 Department of Dermatology, Paracelsus Medical University Salzburg, Salzburg, Austria, 2 Department of Pediatrics, Paracelsus Medical University Salzburg, Salzburg, Austria, 3Institute of Pathology, Paracelsus Medical University Salzburg, Salzburg, Austria, 4 Laboratory for Pathology Weger/Emberger, Salzburg, Austria and 5Department of Pediatrics, Research Program for Receptor Biochemistry and Tumor Metabolism, Paracelsus Medical University Salzburg, Salzburg, Austria

16.30–16.40 045 (Poster 522) N-Oct3 is a tumor suppressor and acts as a radioprotector L Larue Institut Curie, Orsay, France

16.40–16.50 046 (Poster 529) Microphthalmia-associated transcription factor regulates dynamic melanoma heterogeneity NK Haass,1,2 L Spoerri,1 CA Tonnessen,1 KA Beaumont,2 DS Hill,2 RJ Jurek,2 SM Daignault,1 F Ahmed,1 AG Smith1 and W Weninger2 1 University of Queensland Diamantina Institute, Woolloongabba, QLD, Australia and 2 Centenary Institute, Sydney, NSW, Australia

16.50–17.00 047 (Poster 538) Transdifferentiation of melanoma cells by the reprogramming factors lose malignant nature in vitro and in vivo M Takaishi and S Sano Dermatology, Kochi Medical School, Nankoku, Japan

17.00-1710 048 (Poster 540) Tumor cell-derived complement components C1r and C1s promote growth of cutaneous squamous cell carcinoma P Riihilä,1,2 K Viiklepp,1,2 L Nissinen,1,2 M Farshchian,1,2 M Kallajoki,3 A Kivisaari,1,2 S Meri,4 R Grénman,5 S Peltonen,1 J Peltonen6 and V Kähäri1,2 1 Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland, 2 MediCity Research Laboratory, University of Turku, Turku, Finland, 3Department of Pathology, Turku University Hospital, Turku, Finland, 4 Haartman Institute, University of Helsinki, Helsinki, Finland, 5 Department of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital, Turku, Finland and 6 Department of Anatomy and Cell Biology, University of Turku, Turku, Finland

17.10-17.20 049 (Poster 537) Accelerated endogenous mutation rate drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa RJ Cho,2 V Atanasova,1 N den Breems,3 L Alexandrov,4 K Tsai5 and A South1 1 Thomas Jefferson University, Philadelphia, PA, 2 UCSF, San Francisco, CA, 3 University of Auckland, Auckland, New Zealand, 4 Los Alamos National Laboratory, Los Alamos, NM and 5 Moffitt Cancer Center, Tampa Bay, FL

17.20-17.30 050 (Poster 528) fMicroRNA-130a (miR-130a) regulates self-renewal capacity and tumor growth in cutaneous squamous cell carcinoma W Lohcharoenkal, K Das Mahapatra, N Xu Landén, E Sonkoly and A Pivarcsi Department of Medicine, Unit of Dermatology and Venereology, Karolinska Institutet, Stockholm, Sweden

CONCURRENT SESSION 5: MELANOMA & OTHER SKIN CANCERSDate: Friday 29 September 2017Time: 16.10–17.35Room: Mozart Hall 1+2+3, Ground FloorChairs: Andreas Baur, Lionel Larue

16.50–17.00 039 (Poster 176) A Distinct Cutaneous Blistering Phenotype with Multi-System Manifestations Caused by a Mutation in CD151, the 20th Causative Gene in Epidermolysis Bullosa J Uitto,1 L Youssefian,1 A Saeidian,1 H Mahmoudi,2 A Touati,1 J McGrath,4 S Zeinali,2 P Fortina3 and H Vahidnezhad1 1 Dermatology and Cutaneuous Biology, Thomas Jefferson University, Philadelphia, PA, 2 Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of), 3 Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA and 4 Dermatology, St. John’s Institute, London, United Kingdom

17.00–1710 040 (Poster 192) Loss of keratinocyte type VII collagen induces increased DNA damage in vitro and in vivo S Marsh,1 M Caley,1 V Martins,1 MR Barnes,2 M Chen3 and EA O’Toole1 1 Centre for Cutaneous Research, Barts and The London School of Medicine and Dentistry, Whitechapel, United Kingdom, 2 Genome Centre, QMUL, London, United Kingdom and 3 Department of Dermatology, USC, Los Angeles, USA

17.10–17.20 041 (Poster 190) Biallelic correction of recessive dystrophic epidermolysis bullosa mutations in iPSCs using CRISPR/Cas9- based genme editing J Jackow,1 Z Guo,1 E Abaci,1 Y Doucet,1 C Hansen,1 J Salas-Alanis2 and A Christiano1 1 Dermatology, Columbia University, New York, NY and 2 Univeridad de Monterrey, Monterrey, Mexico

17.20–17.30 042 (Poster 204) Epidermodysplasia verruciformis: Clinical, viral, and histopathological phenotype in patients with EVER3 mutation E Imahorn,1 SJ de Jong,2 I Spoerri,1 W Kempf,3 C Imhof,4 P Häusermann,5 E Jouanguy,2 J Casanova,2 B Burger1 and P Itin1,5 1 Department of Biomedicine, University Hospital of Basel and University of Basel, Basel, Switzerland, 2 St. Giles Laboratory, The Rockefeller University, New York City, NY, 3 Kempf and Pfaltz Histological Diagnostics, Zurich, Switzerland, 4 Stadtpraxis Brig, Brig, Switzerland and 5 Department of Dermatology,University Hospital Basel, Basel, Switzerland

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FRIDAY W W W.ESDR2017.ORG

Saturday 30 September 2017

FRIDAY

Program

CONCURRENT SESSION 6: HAIR & OTHER ADNEXAL STRUCTURESDate: Friday 29 September 2017Time: 16.10–17.35Room: Mozart Hall 4+5, Ground FloorChairs: Michaela Fry, Caterina Missero

16.10–16.20 051 (Poster 245) Tight junction barriers in sebaceous glands are crucial for proper terminal differentiation of sebocytes A Kubo,1 T Atsugi,1,2 M Yokouchi,1,3 A Hirabayashi,4 M Ohyama5 and M Amagai1 1 Department of Dermatology, Keio University School of Medicine, Tokyo, Japan, 2KOSÉ Corporation, Tokyo, Japan, 3 Nerima General Hospital, Tokyo, Japan, 4 RIKEN Center for Integrative Medical Science Center, Yokohama, Japan and 5 Kyorin University, Tokyo, Japan

16.20–16.30 052 (Poster 248) Engineering novel human sweat gland cell lines using CRISPR/Cas9 and primary cell technologies A Wursthorn,1 T Sturmheit,2 Ü Pul,1 J Kier,2 M Brandenburger2 and T Ertongur-Fauth1 1 BRAIN AG, Zwingenberg, Germany and 2 Fraunhofer EMB, Lubeck, Germany

16.30–16.40 053 (Poster 246) miR-486 Plays a Protective Role in Hair Follicle Immune Privilege Collapse in Alopecia Areata D Broadley,1 A Sharov,3 J Sundberg,4 M Bertolini,2 AN Mardaryev1and NV Botchkareva1 1 University of Bradford, Bradford, United Kingdom, 2 University of Munter, Munster, Germany, 3 Dermatology, Boston University, Boston, MA and 4 The Jackson Laboratory, Bar Harbor, ME

16.40–16.50 054 (Poster 257) Is EBF1 a negative regulator of WNT10A in the development of androgenetic alopecia? LM Hochfeld,1 A Woitecki,2 K Pernhorst,2 JA Müller,2 FB Basmanav,1 M Philpott,3 S Schoch,2 RC Betz,1 MM Nöthen1 and S Heilmann-Heimbach1 1 Institute of Human Genetics, Dept. Genomics, University of Bonn, Bonn, Germany, 2 Dept. of Neuropathology, University of Bonn Medical Center, Bonn, Germany and 3 Cell Biology&Cutaneous Research, Queen Mary University London, London, United Kingdom

16.50–17.00 055 (Poster 253) Opsins and Cryptochrome photoreceptors mediate blue light stimulatory effect on hair growth S Buscone,1,2 NE Uzunbajakava,1 AN Mardaryev2 and NV Botchkareva2 1 Health Care and Wellness, Philips Research, Eindhoven, Netherlands and 2 Center for Skin Sciences, University of Bradford, Bradford, United Kingdom

17.00–1710 056 (Poster 252) Follicle dermal papilla cells undergo chromatin remodelling processes in vivo and in vitro E Carrasco,1 A Gilmore,1 V Botchkarev2 and CA Jahoda1 1 Biosciences, Durham University, Durham, United Kingdom and 2 Centre for Skin Sciences, University of Bradford, Bradford, United Kingdom

17.10–17.20 057 (Poster 259) Immunohistochemical insight into the association between the collapse of immune privilege in the sweat gland and syringotropic immune cell infiltrates in collagen diseases Y Shimoda, Y Yamazaki and M Ohyama Department of Dermatology, Kyorin University School of Medicine, Mitaka, Japan

17.20–17.30 058 (Poster 266) Glycogen metabolism and Cori cycle in human hair follicles K Figlak,1 R Paus2 and M Philpott1 1 Centre for Cell Biology and Cutaneous Research, Blizard Institute, School of Medicine and Dentistry, Barts and the London, Blizard Institute, QMUL, London, United Kingdom and 2 Dermatology Res Ctr, Inst. Of Inflammation & Repair, University of Manchester, Manchester, United Kingdom

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SATURDAYProgram

CONCURRENT SESSION 7: INFLAMMATION, IMMUNITY & INFECTION 2Date: Saturday 30 September 2017Time: 09.00–10.30Room: Europa Hall, 2nd floorChairs: Kilian Eyerich, Christina Zielinski

09.00–09.10 059 (Poster 340) Peripheral nerves promote basophil infiltration via TLR2 in murine atopic-dermatitis-like inflammation C Nakashima, A Otsuka and K Kabashima Dermatology, Kyoto University, Kyoto, Japan

09.10–09.20 060 (Poster 293) dentification of amino acids that equip lipocalins with allergenic potential DD Klaver,1 B Posch,1 A Geisler,1 N Reider,1 B Redl2 and C Heufler1 1 Dermatology, Medical University of Innsbruck, Innsbruck, Austria and 2 Mol Biol, Medical University of Innsbruck, Innsbruck, Austria

09.20–09.30 061 (Poster 297) Treatment with KdPT ameliorated ongoing skin inflammation by inducing Treg but did not increase the susceptibility towards infection N Mykicki,1 C Baumann,1 M Soeberdt,2 C Abels,2 TA Luger1 and K Loser1

1Dept. Dermatol., Univ. of Munster, Munster, Germany and 2 Dr. August Wolff GmbH Co. KG, Bielefeld, Germany

09.30–09.40 062 (Poster 316) Universal Transcriptomic Analysis of Host-Microbiome Interactions in Psoriasis T Furnholm,1 M Foo,1 L Reingold,1 K Shedden2 and A Johnston1 1 Dermatology, University of Michigan, Ann Arbor, USA and 2 CSCAR, University of Michigan, Ann Arbor, USA

09.40–09.50 063 (Poster 296) High-dose immunoglobulin contains anti-idiotypic antibodies against BP-IgG M Kamaguchi,1,2 H Iwata,1 Y Mori,1 H Ujiie,1 Y Kitagawa2 and H Shimizu1 1 Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan and 2Oral Diagnosis and Medicine, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan

09.50–10.00 064 (Poster 320) ADAM10-induced Cleavage of Semaphorin 4D from Eosnophils Contributes to Antibody Production in Bullous Pemphigoid S Shen, Y Ke, E Dang, T Zhang, H Qiao and G Wang Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China

10.00–10.10 065 (Poster 321) Human skin-resident innate-like T cells in health and disease R Woolf,2,1 O Nussbaumer2 and A Hayday2,3 1 St John’s Institute of Dermatology, King’s College London, UK, London, United Kingdom, 2 Department of Immunobiology, King’s College London, UK, London, United Kingdom and 3 Francis Crick Institute, London, United=Kingdom

10.10–10.20 066 (Poster 298) Fli1-deficient adipocytes promote the spontaneous development of dermal fibrosis and vasculopathy mimicking systemic sclerosis through adipocytes-to-myofibroblast transdifferentiation and defective vasculogenesis T Miyagawa,1 Y Asano,1 R Saigusa,1 K Nakamura,1 M Hirabayashi,1 T Yamashita,1 S Miura 1 T Taniguchi,1 A Yoshizaki,1 M Trojanowska2 and S Sato1 1 Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan and 2 Boston University School of Medicine Boston, USA

Program

CONCURRENT SESSION 8: CLINICAL OUTCOMESDate: Saturday 30 September 2017Time: 09.00–10.30Room: Mozart Hall 1+2+3, Ground FloorChairs: Hervé Bachelez, Marjan Garmyn

09.00–09.10 067 (Poster 011) Pediatric cancers in neurofibromatosis type 1 S Peltonen,1 R Matti,2 R Kallionpää,3 J Pitkäniemi2 and J Peltonen3 1 Dept. of Dermatol., Univ. of Turku and Turku Univ. Hosp., Turku, Finland, 2 Finnish Cancer Registry, Helsinki, Finland and 3 Instit. of Biomedicine, Univ. of Turku, Turku, Finland

09.10–09.20 068 (Poster 203) Preliminary therapeutic target validation of the IL-36 receptor in psoriasis SK Mahil,1 M Peakman,1 R Trembath,1 J Wright,2 J Barker1 and F Capon1 1 King’s College London, London, United Kingdom and 1 Bradford Royal Infirmary, Bradford, United Kingdom

09.20–09.30 069 (Poster 023) Eosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome D Giusti,1,2 G Gatouillat,1,2 S Le Jan,1 J Plée,1,3 P Bernard,1,3 FD Antonicelli1 and B Pham1,2 1 Dermatology, University of Reims Champagne-Ardenne, Reims, France, 2 Immunology, Reims University Hospital, Reims, France and 3 Dermatology, Reims University Hospital, Reims, France

09.30–09.40 070 (Poster 019) Distinct clinicopathologic and radiological manifestations of the skin, lung, and muscle diseases in patients with dermatomyositis positive for anti-aminoacyl tRNA synthetase antibodies H Fukamatsu,1 Y Hirai,1 T Kaji,1 S Morizane,1 E Yokoyama,1 T Hamada,1 T Oono2 and K Iwatsuki1 1 Dermatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan and 2 Dermatology, Okayama Red-Cross Hospital, Kita-ku Okayama, Japan

09.40–09.50 071 (Poster 007) Sustained Response Following Withdrawal of Guselkumab Treatment Correlates With Reduced Th17 and Th22 Effector Cytokine Levels P Branigan, X Liu, Y Chen, B Scott, Z Yao, S Li, Y Wasfi, M Song, K Campbell and E Muñoz-Elías Janssen Research & Development, LLC, Spring House, USA

09.50–10.00 072 (Poster 002) Switching treatments of etanercept biosimilar GP2015 with originator product does not impact efficacy, safety and immunogenicity in patients with chronic plaque-type psoriasis CE Griffiths,1 K Reich,2 D Thaçi,3 S Gerdes,3 P Arenberger,4 K Kingo,5 J Weglowska6 and H Woehling7 1 University of Manchester, Manchester, United Kingdom, 2Dermatologikum Hamburg, SCIderm GmbH, Hamburg, Germany, 3 University Hospital Schleswig-Holstein, Lubeck and Kiel, Germany, 4 Charles University, Prague, Czech Republic, 5 Tartu University Hospital, Tartu, Estonia, 6 Szpital Specjalistyczny we Wroclawiu, Wroclaw, Poland and 7 HEXAL AG/Sandoz, Holzkirchen, Germany

10.00–10.10 073 (Poster 004) Patients with hidradenitis suppurativa have a high psychiatric disease burden: A Finnish nationwide registry study L Huilaja,1 H Tiri,1 J Jokelainen,2 M Timonen2 and K Tasanen11 Department of Dermatology, University of Oulu, Oulu, Finland and 2 Center for Life Course Epidemiology and Systems Medicine, University of Oulu, Oulu, Finland

10.10–10.20 074 (Poster 527) Safety dose and prediction of immune-related adverse event of nivolumab combined with IFN-beta in patients with advanced melanoma T Fujimura, Y Kambayashi, S Furudate, T Hidaka, K Tanita, Y Sato and S Aiba Dermatology, Tohoku University, graduate school of medicine, Sendai, Japan

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SATURDAY

SATURDAYProgram

CONCURRENT SESSION 9: WOUND HEALING & TISSUE REMODELLINGDate: Saturday 30 September 2017Time: 09.00–10.30Room: Mozart Hall 4+5, Ground FloorChairs: Maria José Escamez, Paola Zigrino

09.00–09.10 075 (Poster 671) Comprehensive analysis on HMGB1-induced circulating cells during cutaneous tissue regeneration T Shimbo,1 M Nishida,2 T Kitayama,2 R Yamamoto,2 E Takaki,2 Y Kikuchi,1 Y Kaneda3 and K Tamai1 1 Stem Cell Therapy, Osaka University, Suita, Japan, 2 Genomix Co., Ltd., Ibaraki, Japan and 3 Gene Therapy Science, Osaka University, Suita, Japan

09.10–09.20 076 (Poster 674) Discoidin domain receptor 2 signaling regulates matrix remodeling in human skin dermal fibroblast Y Shitomi, S Matsukuma, S Ishiwatari and T Sakurai Fancl Research Institute, Yokohama, Japan

09.20–09.30 077 (Poster 302) A novel population of skin-tropic T cells with a potential role in wound healing MM Klicznik,1 T Duhen,2 S Motley,2 B Hoellbacher,1,2 A Sir,3 R Reitsamer,3 EM Murauer,4 DJ Campbell2 and IK Gratz1,4 1 Molecular Biology, University of Salzburg, Salzburg, Austria, 2 Benaroya Research Institute, Seattle, WA, 3 Breast Center, University Hosptial Salzburg, Salzburg, Austria and 4 EB House Austria, Paracelsus Medical University, Salzburg, Austria

09.30–09.40 078 (Poster 663) Differential roles of atypical protein kinase C isoforms in wound healing S Osada,1 N Noguchi,1 T Hirose,2 T Suzuki,1 M Kagaya,1 K Chida,3 S Ohno2 and M Manabe1 1 Department of Dermatology & Plastic Surgery, Akita University Graduate School of Medicine, Akita, Japan, 2 Department of Molecular Biology, Yokohama City University Graduate School of Medicine, Yokohama, Japan and 3Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan

09.40–09.50 079 (Poster 660) Comparison of microRNAome of human normal and chronic wounds reveals microRNA-17~92 is critical for wound repair D Li,1 J Wikstrom,1 E Herter,1 X Li,1 A Pivarcsi,1 E Sonkoly,1 M Ståhle,1 Q Mi,2 L Zhou2 and N Xu Landén1 1 Department of Medicine, Karolinska Institutet, Stockholm, Sweden and 2 Henry Ford Health System, Detroit, USA

09.50–10.00 080 (Poster 659) Long non-coding RNA WANCR1 regulates skin wound healing by enhancing keratinocytes migration D Li,1,2 E Herter,1,2 X Li,1,2 A Wang,3 J Wikstrom,1,2 E Sonkoly,1,2 A Pivarcsi,1,2 M Stahle1,2 and N Xu Landén1,2 1 Department of Medicine, Karlolinska Institutet, Stockholm, Sweden, 2 Unit of Dermatology and Venereology, Karolinska University Hospital, Stockholm, Sweden and 3 Department of Dermatology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China

10.00–10.10 081 (Poster 664) Thrombospondin 1 is a major activator of TGF-beta in Recessive Dystrophic Epidermolysis Bullosa VS Atanasova,1 R Russell,1 TG Webster,1 J Salas2 and A South1 1 Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, USA and 2Dermatology, University of Monterrey, Monterrey, Mexico

10.10–10.20 082 (Poster 662) Deletion of Notch signalling in the vasculature accelerates Endothelial to Mesenchymal Transition in skin wound healing J Patel, B Baz, H Wong, JS Lee and K Khosrotehrani Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia

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SATURDAY

MICHAEL HERTLProfessor and Chairman, Department of Dermatology and Allergology, Philipps University Marburg, Germany

Date: Saturday 30 September 2017Time: 11.35–12.05Room: Europa Hall, 2nd floorLecture Title: Autoimmune bullous disorders – translational insights Introduced by: Luca Borradori

The major focus of the Hertl lab is to characterize the immunological network leading to T cell dependent B cell activation, and eventually, autoantibody production in autoimmune bullous skin disorders and related diseases. Based on our improved understanding of the pathogenesis of pemphigus and the pemphigoids, novel targeted strategies, including immunoadsorption and rituximab, have been introduced into the therapeutic armamentarium of these potentially lethal and hard-to-treat-disorders. Our improved knowledge of various cutaneous autoantigens which may serve as targets in clinically unrelated inflammatory skin disorders has helped to understand the effector function of distinct T cell subsets involved in these inflammatory processes. Overall, also rare, pemphigus and pemphigoid, are increasingly recognized as model diseases of autoantibody-related autoimmunity in general.

2017 EADV Guest Lecture

SATURDAYEADV/ESDR CLINICAL SATURDAY LECTURESDate: Saturday 30 September 2017, Time: 12.10–13.40Room: Europa Hall, 2nd floorChairs: Menno de Rie, Martin Röcken

About Clinical SaturdayTo increase the exchange between basic scientists and clinicians at the annual meeting, the ESDR includes „Clinical Saturday“ as part of the regular program. By offering Clinical Saturday lectures, the EADV Guest Lecture and industry sponsored symposia, the ESDR hopes to make the meeting as attractive for clinicians as it always has been for basic scientists. Clinical Saturday 2017 is run in association with the European Academy for Dermatology and Venereology (EADV).

12.10–12.40 Unmet Needs: Neglected Niches for Dermatology ResearchGeorg Stingl (Vienna, Austria)

12.40–13.10Therapy-relevant Research for Rare Genetic Skin DisordersEdel O‘Toole (London, UK)

13.10–13.40Vitiligo: From Pathogenesis to New Therapeutic TargetsJulien Seneschal (Bordeaux, France)

Program

EPIDERMAL HOMEOSTASIS AND RARE DISEASEDate: Saturday 30 September 2017Time: 12.15–13.30Room: Mozart Hall 1+2+3, Ground FloorChairs: Peter Elias, David Kelsell

This ESDR session is supported by an educational grant from Clé de Peau Beauté SHISEIDO

12.15–12.30 The keratinocyte environment reflects the molecular steps of malignant melanocyte transformation Andreas Baur (Erlangen, Germany)

12.30–12.45 Topical diacerein for epidermolysis bullosa Johann Bauer (Salzburg, Austria)

12.45–13.00 Treating skin disease with microbes Richard Gallo (San Diego, USA)

13.00–13.15 Intracellular transport and homeostasis: Implications in epidermal diseases Mahendra Sonawane (Mumbai, India)

13:30–14:00 ESDR Poster Prizes & Closing ceremony

Notes

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SATURDAY

SATURDAYSKIN EPIGENETICSDate: Saturday 30 September 2017Time: 14.00–17.00Room: Mozart 1+2+3, Ground FloorChairs: Salvador Aznar Benitah (Barcelona) and Vladimir Botchkarev (Bradford/Boston)

14.00–14.05 Introductory remarks Salvador Aznar Benitah (Barcelona) and Vladimir Botchkarev (Bradford/Boston)

14.05–14.35 Opening Keynote Lecture Michaela Frye (Cambridge)

14.35–14.55 Epigenetic mechanisms regulating epidermal homeostasis and cancer Salvador Aznar Benitah (Barcelona)

14.55–15.15 Polycomb genes Elena Ezhkova (New York)

15.15–15.30 Cbx4 in the control of wound healing Andrei Mardaryev (Bradford)

15.30–15.45 Mechanisms of long non-coding RNA-mediated control of epidermal homeostasis Markus Kretz (Regensburg)

15.45–16.00 Ultra-conserved non-coding transcript T-UC291 controls keratinocyte differentiation by interfering with ACTL6A Eleonora Candi (Rome)

16.00–16.15 Transcription factor p63, a master regulator of the enhancer landscape during epidermal differentiation Jo Zhou (Nijmegen)

16.15–16.30 Biomechanical regulation of nuclear architecture in keratinocytes John Connelly (London)

16.30–16.45 Boosting autophagy: potential anti-aging therapy Karima Djabali (Munich)

16.45–17.00 Concluding remarks Salvador Aznar Benitah (Barcelona) and Vladimir Botchkarev (Bradford/Boston)

Program

INNOVATION AND ENTREPRENEURSHIP IN SKIN SCIENCEDate: Saturday 30 September 2017Time: 14.00–17.00Room: Mozart Hall 4+5, Ground FloorChairs: Michel Gilliet and Chris Griffiths

Supported by:

Program14.00–14.15 Advancing Innovation in Dermatology

William Ju (New York, USA)

14.15–14.30 Teaching Young Dermatologists and Skin Scientists to become Entrepreneurs – The Magic Wand Project Lilit Garibyan (Boston, USA)

14.30–14.45 IP as a Platform for Innovation: Why, How and When Should I Protect my Data Rich Ferrie (Manchester, UK)

14.45–15.00 Innovation in Pharma Michael Sierra (LEO Science and Tech Hub, Cambridge, USA)

15.00–15.45 My Personal Experience in Creating a Start-Up Colin Jahoda (Durham, UK) Carlo Pincelli (Modena, Italy) Cath O’Neill (Manchester, UK)

15.45–16.15 Panel Discussion and Q&A

16.15–17.00 Networking

— 60 — — 61 —

SATURDAY

PracticalA-Z Information

Notes

— 62 — — 63 —

AT/C

OTE/

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1

* GEMEINSAM STÄRKER Beim fortgeschrittenen, BRAF-mutierten Melanom2

Indikation: bei inoperablem oder metastasiertem BRAFV600-mutiertem Melanom.1

1 Fachinformation Cotellic®, Stand Mai 2017. 2 Ascierto P et al. LancetOncol 2016; S1470-2045(16):30122.

Cotellic®: Dieses Arzneimittel unterliegt einer zusätzlichen Überwachung. Dies ermöglicht eine schnelle Identi� zierung neuer Erkenntnisse über die Sicherheit. Angehörige von Gesundheitsberufen sind aufgefordert, jeden Verdachtsfall einer Nebenwirkung zu melden. Meldung von Nebenwirkungen an: Bundesamt für Sicherheit im Gesundheitswesen, Traisengasse 5, 1200 Wien, Österreich, Fax: + 43 (0) 50 555 36207, Website: http://www.basg.gv.at/ und an Roche Austria GmbH, www.roche.at.

Cotellic® 20 mg Filmtabletten. Qualitative und quantitative Zusammensetzung: Jede Filmtablette enthält Cobimetinibhemifumarat, entsprechend 20 mg Cobimetinib. Sonstiger Bestandteil mit bekannter Wirkung: Jede Filmtablette enthält 36 mg Lactose- Monohydrat. Liste der sonstigen Bestandteile: Tablettenkern: Lactose-Monohydrat, Mikrokristalline Cellulose (E460), Croscarmellose-Natrium (E468), Magnesiumstearat (E470b). Filmüberzug: Poly(vinylalkohol), Titandioxid (E171), Macrogol 3350, Talkum (E553b). Anwendungsgebiete: Cotellic wird in Kombination mit Vemurafenib angewendet zur Behandlung bei erwachsenen Patienten mit nicht resezierbarem oder metastasiertem Melanom mit einer BRAF-V600-Mutation (siehe veröffentlichte Fachinformation Abschnitte 4.4 „Besondere Warnhinweise und Vorsichtsmaßnahmen für die Anwendung“ und 5.1 „Pharmakodynamische Eigenschaften“). Gegenanzeigen: Überemp� ndlichkeit gegen den Wirkstoff oder einen der sonstigen Bestandteile. Inhaber der Zulassung: Roche Registration Limited, 6 Falcon Way, Shire Park, Welwyn Garden City, AL7 1TW, Vereinigtes Königreich Verschreibungsp� icht/Apothekenp� icht: Rezept- und apothekenp� ichtig, wiederholte Abgabe verboten Pharmakotherapeutische Gruppe: Antineoplastische Mittel, ATC-Code: L01XE38 Besondere Warnhinweise und Vorsichtsmaßnahmen für die Anwendung, Wechselwirkungen mit anderen Arzneimitteln und sonstige Wechselwirkungen sowie Informationen zu Schwangerschaft und Stillzeit und zu Nebenwirkungen sind der veröffentlichten Fachinformation zu entnehmen. Mai 2017

Zelboraf® 240 mg Filmtabletten.Qualitative und quantitative Zusammensetzung: Jede Tablette enthält 240 mg Vemurafenib (als Kopräzipitat von Vemurafenib und Hypromelloseacetatsuccinat). Liste der sonstigen Bestandteile: Tablettenkern: Croscarmellose-Natrium, hochdisperses Siliciumdioxid, Magnesiumstearat, Hyprolose; Filmüberzug: Poly(vinylalkohol), Titandioxid (E 171), Macrogol 3350, Talkum, Eisen(III)-oxid (E 172). Anwendungsgebiete: Vemurafenib ist angezeigt als Monotherapie zur Behandlung von erwachsenen Patienten mit BRAF-V600 Mutation-positivem nicht resezierbarem oder metastasiertem Melanom (siehe veröffentlichte Fachinformation Abschnitt 5.1 „Pharmakodynamische Eigenschaften“). Gegenanzeigen: Überemp� ndlichkeit gegen den Wirkstoff oder einen der sonstigen Bestandteile. Inhaber der Zulassung: Roche Registration Limited, 6 Falcon Way, Shire Park, Welwyn Garden City, AL7 1TW, Vereinigtes Königreich. Verschreibungsp� icht/Apothekenp� icht: rezept- und apothekenp� ichtig, wiederholte Abgabe verboten. Pharmakotherapeutische Gruppe: Antineoplastische Mittel, Proteinkinase Inhibitor, ATC-Code: L01XE15. Besondere Warnhinweise und Vorsichtsmaßnahmen für die Anwendung, Wechselwirkungen mit anderen Arzneimitteln und sonstige Wechselwirkungen sowie Informationen zu Schwangerschaft und Stillzeit und zu Nebenwirkungen sind der veröffentlichten Fachinformation zu entnehmen. September 2016

HEUTE LEBEN. MORGEN LEBEN. BESSER LEBEN.

GEMEINSAMSTÄRKER

*

PO

STER

S

PRINTED POSTERSPoster Board and MaterialThe maximum size of your poster should be 120 cm (height) 90 cm (width). Posters should be in Portrait/Vertical format.Your poster number will be displayed with large printed figures on the poster board. Your poster material should be attached on the surface by material provided by the ESDR meeting staff in the poster area.

Poster ExhibitionPosters will be displayed for the duration of the meeting.Presenters must stand with their posters during formal viewing sessions.

Installation and Removal• Printed posters must be installed

on Wednesday 27 or Thursday 28 September (poster areas open at 09.00). If you have used ESDR's poster printing service, please collect your poster from the registration desk.

• Please remove your poster by 17.00 on Saturday 30 September. Posters remaining after this time will be destroyed.

ELECTRONIC POSTERSAll 2017 ESDR posters will be available for viewing throughout the meeting at the Electronic Poster Kiosks. This area contains 20 large screens and is only available for poster viewing (no Internet connection). The Electronic Poster technology enables fast browsing/search and a facility to contact the author. A technician will be available to assist with any questions/problems.

Sponsored by:

VIDEO POSTER PRESENTATIONSNew in 2017ESDR Poster presenters have an opportunity to upload a video presentation of their posters while at ESDR 2017 in Salzburg. Working with a professional video team, you will be able to see your poster and record a 4-5 minute talk that we will upload to our video channel. This opportunity is limited to 50 poster presenters so please select your slot early. To participate, please visit the esdr2017.org website.

ESDR Poster PrizesThe ESDR Poster Prizes ceremony takes place on Saturday, 30 September in Europa Hall between 13.45–14:00 as a part of the Closing ceremony.

Sponsored by:

POSTER WALKSThose presenters selected for a Poster Walk should assemble in front of the indicated kiosk at the start of each Poster Walk Session. The walk leaders will moderate the sessions and each presenter should be prepared to present his/her electronic poster from a tablet computer connected to a large screen (microphone available). Please ensure you have submitted your electronic poster ahead of the meeting!Expect to speak for 3-4 minutes and answer a couple of questions from the group.These sessions are open to all delegates so even if you are not presenting, please feel free to join a group.

More information about poster walks can be found on the following pages as well as on the ESDR 2017 website.

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POSTERS

POSTERWALKJDATE TIME POSTER WALK NUMBER

SESSION KIOSK NUMBER

PRESENTED POSTERS NUMBERS KIOSK LOCATION LEADER

Friday 29 September 2017 11.30–12.25 1 Epidermal Structure and Function 1 1 089; 096; 104; 106; 111; 112; 113; 132 2nd Floor Sirkku Peltonen

Friday 29 September 2017 11.30–12.25 2 Inflammation, Immunity and Infection 1: Allergic contact dermatitis, atopic dermatitis 3 105; 183; 295; 299; 317; 323; 346; 347; 350; 374; 386 2nd Floor Thomas Werfel

Friday 29 September 2017 11.30–12.25 3 Inflammation, Immunity and Infection 2: Autoimmune bullous dermatosis; vitiligo 5 324; 335; 355; 358; 362; 370; 383; 391; 395 2nd Floor Michael Hertl

Friday 29 September 2017 11.30–12.25 4 Inflammation, Immunity and Infection 3: Psoriasis 9 314; 315; 322; 325; 327; 337; 341; 344; 348; 365 2nd Floor Marta Szell

Friday 29 September 2017 11.30–12.25 5 Inflammation, Immunity and Infection 4: Keratinocytes, inflammation and related aspects 11 191; 306; 308; 332; 339; 361; 369; 378; 380; 394; 405 2nd Floor Karin Loser

Friday 29 September 2017 11.30–12.25 6 Wound Healing and Tissue Remodelling 1 12 661; 666; 667; 672; 673; 676; 678; 682; 683 2nd Floor Teresa Odorisio

Friday 29 September 2017 11.30–12.25 7 Melanoma and other Skin Cancers 1: Lymphoma ; Basic aspects 16 201; 522; 531; 535; 543; 551; 552; 554; 556; 568 3rd floor Eugene Healy

Friday 29 September 2017 11.30–12.25 8 Genetics and Cell Based Therapy 1 17 178; 184; 187; 188; 193; 196; 197; 198; 199; 207; 208 3rd floor Andrew South

Friday 29 September 2017 11.30–12.25 9 Photobiology and Pigmentation 1 18 413; 621; 622; 623; 628; 629; 632; 634; 638 3rd floor Hamid Reza Rezvani

Friday 29 September 2017 11.30–12.25 10 Hair and Other Adnexal Structures 1: Hair 20 244; 249; 251; 255; 261; 263; 264; 268; 269 3rd floor Marta Bertolini

Friday 29 September 2017 14.35–15.30 11 Epidermal Structure and Function 2 1 101; 109; 118; 121; 123; 125; 126; 130 2nd Floor Salvador Aznar-Benitah

Friday 29 September 2017 14.35–15.30 12 Epidermal Structure and Function 3 3 093; 094; 099; 103; 110; 116; 127; 265 2nd Floor Daniele Bergamaschi

Friday 29 September 2017 14.35–15.30 13 Inflammation, Immunity and Infection 5: T cells, myeloid cells, mast cells 5 319; 330; 336; 352; 356; 359; 366; 388; 392; 393; 407 2nd Floor Luis Santamaria Babi

Friday 29 September 2017 14.35–15.30 14 Inflammation, Immunity and Infection 6: Psoriasis 9 095; 351; 354; 357; 373; 375; 376; 385; 390; 399 2nd Floor Enikö Sonkoly

Friday 29 September 2017 14.35–15.30 15 Inflammation, Immunity and Infection 7: Bacteria, viruses and antimicrobial peptides 11 326; 334; 349; 372; 377; 384; 387; 400; 409; 410 2nd Floor Thomas Volz

Friday 29 September 2017 14.35–15.30 16 Inflammation, Immunity and Infection 8: Fibrosis, sclerosis and related diseases 12 304; 305; 331; 338; 364; 381; 382; 402 2nd Floor Kerstin Steinbrink

Friday 29 September 2017 14.35–15.30 17 Melanoma and other Skin Cancers 2: Melanoma 16 525; 530; 534; 539; 541; 544; 546; 547; 550; 567 3rd floor Lionel Larue

Friday 29 September 2017 14.35–15.30 18 Clinical Outcomes 1: Psoriasis: IPC 17 001; 006; 009; 014; 016; 017; 018; 033; 036; 037; 040 3rd floor Hervé Bachelez

Friday 29 September 2017 14.35–15.30 19 Genetics and Cell Based Therapy 2: Epidermolysis bullosa 18 181; 182; 185; 186; 189; 194; 200; 205; 206; 209; 560 3rd floor Caterina Missero

Friday 29 September 2017 14.35–15.30 20 Photobiology and Pigmentation 2: Effects of UV radiation 20 620; 627; 630; 631; 633; 635; 636; 637; 639 3rd floor Thomas Schwarz

Saturday 30 September 2017 10.30–11.30 21 Epidermal Structure and Function 4: Clinical Aspects 1 098; 102; 107; 108; 115; 117; 119; 124; 128; 131 2nd Floor Menno de Rie

Saturday 30 September 2017 10.30–11.30 22 Hair and Other Adnexal Structures 2: Adnexal Structures 3 247; 250; 256; 258; 260; 262; 267; 270; 271 2nd Floor Mike Philpott

Saturday 30 September 2017 10.30–11.30 23 Inflammation, Immunity and Infection 9: Psoriasis 5 100; 120; 122; 131; 329; 342; 396; 397; 398; 411 2nd Floor Chris Griffiths

Saturday 30 September 2017 10.30–11.30 24 Inflammation, Immunity and Infection 10 9 318; 328; 333; 343; 345; 353; 360; 371; 379; 389 2nd Floor Bernhard Homey

Saturday 30 September 2017 10.30–11.30 25 Inflammation, Immunity and Infection 11: Atopic dermatitis 11 114; 129; 367; 368; 401; 403; 404; 406; 408; 412; 414 2nd Floor Martin Steinhoff

Saturday 30 September 2017 10.30–11.30 26 Wound Healing and Tissue Remodelling 2 12 665; 668; 669; 670; 675; 677; 679; 680; 681; 684 2nd Floor John Connelly

Saturday 30 September 2017 10.30–11.30 27 Melanoma and other Skin Cancers 3: Melanoma 16 021; 553; 555; 557; 559; 562; 563; 564; 565; 569 3rd floor Christian Posch

Saturday 30 September 2017 10.30–11.30 28 Melanoma and other Skin Cancers 4: Epithelial Tumors; miscellaneous aspects 17 536; 542; 545; 548; 549; 558; 561; 566; 570 3rd floor Anissa Chikh

Saturday 30 September 2017 10.30–11.30 29 Clinical Outcomes 2: Acne, atopic dermatitis and other diseases 18 003; 008; 010; 012; 013; 026; 028; 029; 032; 035; 041 3rd floor Robert Swerlick

Saturday 30 September 2017 10.30–11.30 30 Clinical Outcomes 3: Bullous diseases and other entities 20 015; 020; 022; 024; 025; 027; 030; 031; 034; 038; 039 3rd floor Alain Hovnanian

POSTER WALKS

— 66 — — 67 —

AACCOMMODATIONShould you need any help with accommodation please contact our staff at the Registration desk.

AIRPORTSalzburg Airport W.A. Mozart is located 20 minutes from the city centre. There are good connections between the airport and the city centre by public transport – buses and taxis:The bus line no 2 goes daily every 10/20 minutes between Salzburg main railway station and the airport. Sundays and public holidays every 20 min. Journey time approx. 20 min.The bus line no 10 (Mon-Sat) every 10 minutes from the airport via Salzburg city centre (15 min) to Salzburg-Sam.The bus line no 27 goes daily every 15/20 minutes from the airport via Wals/Viehhausen to the railway station. Journey time approx. 40 min.See the bus time tables here.

A taxi stand can be found both directly in front of Salzburg main railway station and the airport terminal taking you directly to the check-in desks.

BBADGESAlong with your registration, you will receive your name badge, which must be worn when attending all sessions and official meeting programme. Participants without a badge will not be allowed to enter the venue building.

CCASH POINTSCredit Suisse AG, Address: Rainerstraße 2, 5020 Salzburg2-minute walking distanceDenizBank AGSchallmooser Hauptstraße 10, 5020 Salzburg10-minute walking distance

CERTIFICATE OF ATTENDANCEAll registered delegates present on site are entitled to receive a Certificate of Attendance. Certificates will be emailed to all on-site registered delegates after the meeting.

CITY OF SALZBURGPlan your visit and find more info at https://www.salzburg.info/en.

CLIMATESalzburg is a city with a mild continental climate. The average temperature in September varies around 20 °C. Umbrellas maybe useful.

CLOAKROOMA cloakroom is located on the ground floor next to the registration, the service is provided free of charge to all registered participants.

COFFEE BREAKSCoffee breaks (included in the registration fees) will be served on the ground floor foyer and in the exhibition area (1st floor).

CURRENCY/EXCHANGEAustria is a member of the Economic and Currency Union and the common currency is the Euro.Exchange offices are located all at the airport and around the city centre (exchange offices, banks).Always check the terms and conditions in exchange offices. Never exchange money at the street.

DDISCLAIMERThe ESDR Organisers have taken all reasonable care in making arrangements for the Meeting, including accommodation. In the event of unforeseen disruptions, neither ESDR nor the ESDR Meeting Organiser nor their agents can be held responsible for any losses or damages incurred by delegates. The programme is correct at the time of printing, but organisers reserve the right to alter the programme if and when deemed necessary. The ESDR Meeting Organisers act as agents only in securing hotels, transport and travel services and shall in no event be liable for acts or omissions in the event of injury, damage, loss, accident, delay or irregularity of any kind whatsoever during arrangements organised through contractors or by the employees of such contractors. Hotel and transportation services are subject to the terms and conditions under which they are offered to the general public. Delegates should make their own arrangements with respect to personal insurance. The ESDR Meeting Organisers reserve the right to make changes as and when deemed necessary without prior notice to the parties concerned.

DOCTOR / FIRST AIDGemeinnützige Salzburger Landeskliniken Betriebsges.mbH LKH – Landesklinik is within a 10-minute walking distance from the venue.Address: Müllner Haupstraße 48, 5020 SalzburgTel.: +43 57 2550

EEMERGENCY CALLGeneral emergency 112Police 133Fire Department 122Medical Service 141

EXHIBITORSExhibition is located on the 1st floor and all exhibitors are listed in the programme. Exhibition opening hours are following:Thursday, 28 September 10:00–17:00Friday, 29 September 10:00–17:00Saturday, 30 September 10:00–14:00

ELECTRICITYThe electricity used in Austria is 220 Volts / 50 Hz (type E French 2-pin electrical adapter plug and electrical outlet identified by two round pins spaced 19 mm apart with a hole for the socket’s male grounding pin. Type E outlet will also accept Type C plugs and Type E plugs will also work in Type F outlets. A transformer is necessary for your electrical and electronic equipment if using different voltage (ie USA, Canada).

I INFORMATION DESKThe registration staff will be happy to help you with questions you may have with regards to the meeting or any other matters.

INSURANCE AND LIABILITYThe Organisers will accept no liability for personal injuries sustained by or for loss or damage to property belonging to meeting participants, accompanying persons either during or as a result of the meeting or during all tours and events.Upon registration participants accept this proviso. Participants are strongly recommended to seek insurance coverage for health and accident, lost luggage and trip cancellation.

INTERNETThere is free Wi-Fi internet connection available. Network name: ESDR 2017 with no password.

LLOST & FOUNDA lost and found service is available at the information desk at the registration. Please hand in all found items and ask for lost items at the Information Desk. Lost or stolen credit cards: call one of the following services to take care of it: Visa + 0800 200 288, await second dial tone and enter 800 892 8134American Express +43 810 910 940Master Card/Eurocard +0800 070 613

MMOBILE PHONESParticipants are kindly requested to keep their mobile phones in the silent mode in all meeting rooms while sessions are being held.

MOBILE APPLICATIONThe ESDR 2017 App will bring themeeting to your smart phone or tablet.You will have instant access to the fullscientific program and updates throughout the meeting. Interactions will be facilitated by the App, allowing you to send messages to other participants. All registeredparticipants have received an invitation to download the application, should yourequire more details, please visit the meeting registration desk.

Sponsored by Almirall

OOFFICIAL MEETING LANGUAGEThe official meeting language is English. No simultaneous translation is provided.

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A–Z

PPARKINGMirabell Congress underground car park (Mirabell-Kongress-Garage) (entrance via Mirabellplatz, 2 minutes walking to the Convention Center)

Sheraton Salzburg underground car park (entrance via Auerspergstrasse, 1-minute walking to the Convention Center)

PHARMACYThe nearest pharmacy is within 4-minute walking distance from the venue.

Salvator-ApothekeMirabellplatz 5, 5020 SalzburgTel: +43 662 871411Opening hours: Mon–Thu 8:00–18:00, Fri–Sat 8:00–12:00, Sunday CLOSED

POSTERSAll posters are to be presented in respective sessions and rooms. For more information about posters please see pages 64–67.

PRESENTATIONS – SPEAKER’S PREVIEW ROOMPlease hand in your presentationsto the technician in the Speakers‘ Preview Room located in the Mezzanine of the 1st floor.Please make sure to hand in your presentation at least 2 hours prior to the start of your assigned session. Our staff in the room will be happy to assist you. The opening hours are the same as the ones of the registration.

PROGRAMME CHANGESThe Organisers cannot assume liability for any changes in the programme due to external or unforeseen circumstances.

RREGISTRATION OPENING HOURSWednesday 27 September 9:00–18:30Thursday 28 September 7:30–18:30Friday 29 September 8:00–18:30Saturday 30 September 8:30– 17:00

REGISTRATION DESKThe registration desk is located on the ground floor of the venue.

RESTAURANTS – AUSTRIAN CUISINEAustrian cuisine is a style of cuisine native to Austria and composed of influences from throughout the former Austro-Hungarian Empire. Regional influences from Italy, Hungary, Bohemia, Germany and the Balkans have had an effect on Austrian cooking, and in turn this fusion of styles was influential throughout the Empire. In Salzburg, Kasnocken (cheese dumplings) are a popular meal, as are freshwater fish, particularly trout, served in various ways. Salzburger Nockerl (a meringue-like dish) is a well-known local dessert.

BreweriesSalzburg is generally regarded as the beer capital of Austria. Ten breweries in and around the city reflect the impressive variety of opportunities available to beer aficionados. From “top dog” Stiegl and venerable Augustiner Bräu Kloster Mülln, to the Weissbierbrauerei and those microbreweries at inns that produce only for their own guests, Salzburg gives you the perfect opportunity to experience the multifaceted world of “amber nectar”.

SSHOPPINGMost shops in Salzburg are open from 8:00 to 17:00, Monday through Saturday, and closed on Sunday.

SMOKING POLICYPlease note that smoking is not permitted anywhere within the venue. Smoking is currently not prohibited in all restaurants, bars, and pubs, however is prohibited in bus/train stops.

SPEED DATINGDelegates can meet with academics or industry representatives in pre-arranged meetings by the ESDR in Speed Dating Area (1st floor) during the Poster sessions on Friday 29 September. More information is available on the meeting website or at the ESDR booth.

TTAXIWith over 50 stands throughout the city, taxis are a quick way to get from A to B. Whether you need to make it to the train station, airport, downtown or your hotel – your personal taxi will have you there in just a matter of minutes!On-call taxi services in SalzburgTaxi 8111 - phone +43662 8111Taxi 2220 - phone +43662 2220You can also use Uber, as it works properly in Salzburg.Taxi 2284 - phone +43662 2284

TIME DIFFERENCEAustria is in the Central European Time Zone. Central European Time (CET) is 1 hour ahead of Greenwich Mean Time

( GMT +1). After the last Sunday in March the time in Austria is shifted back by 1 hour to CET and this remains until the end of September.

TIPPINGIn Austria, many restaurants include tax and a service charge in their bills, vand it is customary to round up the total when paying. Taxi drivers usually receive an extra 10 percent over the meter fare.

TRANSPORTATION IN SALZBURGSalzburg boasts an environmentally-friendly bus system that includes electric trolleybuses running on overhead powerlines.Tickets for the Salzburg public transportation system (“SVV”) - both single-trip as well as 24-hour - within the so-calles “core-zone”, are cheaper when you buy them in advance. Practically all “Trafik” kiosks carry tickets for public transportation. The 24-hour ticket is a very inexpensive option, allowing you to use the city's entire public transporation network.Public transportation is included on the Salzburg Card (bus lines 1-14; Obuslinien 1-14; bus lines “Fa. Albus”: Citybus A, lines 20-28, 34, 35, 151; on Salzburger Lokalbahn trains as far as the Acharting halt).

Bike Rental Salzburg is one of the most cyclist-friendly cities in Austria. A perfect network of bike paths and outstanding infrastructure excite you with the prospect of exploring the City of Mozart and its countless green spaces by bicycle.

VVENUEThe Salzburg Convention Center is located in the heart of the city, next to the “Mirabellgarten” and adjacent to the Sheraton hotel. Many other hotels are to be found within walking distance.

Address: Salzburg Convention Center Auerspergstrasse 6 5020 Salzburg Austria Phone: +43662-88987-0 www.salzburgcongress.at

LOCAL ORGANISING COMMITTEEJohann Bauer, Salzburg (Chair)Martin Laimer, SalzburgRoland Lang, SalzburgVerena Ahlgrimm-Siess, SalzburgJulia Reichelt, SalzburgThomas Ruzicka, MunichTilo Biedermann, MunichGeorg Stingl, ViennaPeter Petzelbauer, ViennaErwin Tschachler, ViennaPeter Wolf, GrazChristine Heufler, InnsbruckNikolaus Romani, InnsbruckPatrizia Stoitzner, InnsbruckSandrine Dubrac, InnsbruckRobert Gruber, Innsbruck

2017 ESDR SCIENTIFIC PROGRAM COMMITTEEDavid Kelsell (Chair)Matthias Schmuth (ESDR president)Michel Gilliet (ESDR president elect)Johann Bauer (ex officio)Caterina MisseroSalvador Aznar-BenitahLionel LarueThomas WerfelMarta Szell

MeetingOrganisers

ESDR OFFICE7 Rue CingriaCH-1205 GenevaSwitzerlandT: +41 22 321 48 90F: +41 22 321 48 92E: [email protected]: http://www.esdr.org

PROFESSIONAL CONGRESS ORGANISERC-INProfessional Congress Event OrganiserPrague Congress Centre, 5. května 65CZ-140 00, Prague 4

— 70 —

A–Z

ESDR YEAR HONORARY MEMBERS 2017 Sarolta Kárpáti (Hungary) Irene Leigh (UK) Yoshiki Tokura (Japan)

2016 Jens-M Schröder (Germany) Giovanna Zambruno (Italy)

2015 Leena Bruckner-Tuderman (Germany) Masayuki Amagai (Japan)

2014 Robin Eady (UK) Wolfram Sterry (Germany)

2013 Peter van de Kerkhof (Netherlands) Ronald Marks (UK) Hiroshi Shimizu (Japan)

2012 Johannes Ring (Germany)

2011 Paul Bergstresser (USA) Koji Hashimoto (Japan) Anders Vahlquist (Sweden)

2010 Alberto Giannetti (Italy) Shinji Shimada (Japan)

2009 Ervin Epstein (USA) Peter Friedmann (UK)

2008 William Cunliffe (UK) Kristian Thestrup-Pedersen (Denmark)

2007 Thomas Krieg (Germany) John Stanley (USA)

2006 Rona MacKie (UK) Rein Willemze (Netherlands)

2003 Georg Stingl (Austria) Jouni Uitto (USA)

2000 Malcolm Greaves (UK) Egon Macher (Germany)

1999 Stefania Jablonska (Poland) Hiroaki Ueki (Japan)

1998 Takeji Nishikawa (Japan) John Voorhees (USA)

1996 Enno Christophers (Germany) Sadao Imamura (Japan) Steve Katz (USA) Willem van Vloten (Netherlands)

Previously Otto Braun-Falco (Germany) awarded Robert Brun (Switzerland) Rudi Cormane (Netherlands) André Kint (Belgium) Charles Lapière (Belgium) Kimmo Mustakallio (Finland) Michel Prunieras (France) Hans Rorsman (Sweden) Ferdinando Serri (Italy) Sam Shuster (UK) Klaus Wolff (Austria)

Alvador Aznar-BenitahHervé BachelezJonathan BarkerJohann BauerRegina BetzTilo BiedermannSara BrownJohn ConnellyAntonio CostanzoMenno De RieWim DeclercqSandrine DubracLeopold EckhartHiva Fassihi

Carsten FlohrMichaela FryeOlivier GaideMarjan GarmynMichel GillietCristina HasBernard HomeyAlain HovnanianGareth InmanDelphine JavelaudMarcel JonkmanVeli-Matti KähäriYork KamenischDavid Kelsell

Lionel LarueThomas MaginThierry MagnaldoJohn McGrathCaterina MisseroCatherin NiemannCarien NiessenTamar NijstenEdel O‘TooleThierry PasseronRalf PausMichael PhilpottMatthias Schmuth Lone Skov

Eli SprecherKerstin SteinbrinkMartin SteinhoffKaisa Tasanen-MäättäDes TobinMaarten VermeerThomas WerfelNorbert WikonkalAntony YoungChristina ZielinskiPaola Zigrino

ESDR HONORARY MEMBERS AND AWARDS

2017 ESDR ABSTRACT REVIEWERS

CURRENT ESDR EXECUTIVE COMMITTEE AND BOARDExecutive CommitteePresidentMatthias Schmuth, Innsbruck

President electMichel Gilliet, Lausanne

Secretary-treasurerMichel Gilliet, Lausanne

Secretary-treasurer electChris Griffiths, Manchester

Past-presidentJonathan Barker, London

Board membersSalvador Aznar-Benitah, BarcelonaHervé Bachelez, ParisMenno De Rie, AmsterdamChris Griffiths, ManchesterMichael Hertl, MarburgAlain Hovnanian, ParisDavid Kelsell, LondonLionel Larue, ParisCaterina Missero, NaplesSirkku Peltonen, TurkuKerstin Steinbrink, MainzMartin Steinhoff, DublinMarta Szell, SzegedThomas Werfel, Hannover

Salvador Aznar-BenitahMartine BagotJonathan BarkerJohann BauerZsuzsanna Bata-CsorgoTilo BiedermannDavid R BickersLeena Bruckner-TudermanAlexander EnkLars E FrenchPeter S FriedmannOlivier GaideMichel GillietGiammaria GiulianiChristopher E.M. GriffithsRussell P. HallEugene HealyAlain HovnanianGail JenkinsRoland KaufmannDavid KelsellThomas KriegE Birgit LaneAntti LauermaLotus Mallbris

Ludovic MartinCornelia MauchDedee F MurrellMauro M. PicardoCarlos PincelliVincent PiguetGerd PlewigNicholas J ReynoldsLesley E RhodesJohannes RingMartin RöckenJörg SchallerMatthias SchmuthThomas SchwarzMona StahlePeter SteijlenGeorg StinglAnna ThomasSandra TrompezinErwin TschachlerJouni UittoPeter CM van de KerkhofMaarten H VermeerJohn J Voorhees

ESDR PATRON MEMBERSESDR Patron Members support the society through increased annual membership dues. The ESDR would like to thank the following Patron Members for their valuable support.

2018 International Investigative DermatologyOrlando, Florida, USA16–19 May 2018

201949th Annual ESDR MeetingBordeaux, France18–21 September 2019

202050th Annual ESDR MeetingAmsterdam, The Netherlands2–5 September 2020

FUTURE ESDR MEETINGS

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ESDR

SECRETARYM. PrunierasM. PrunierasM. PrunierasM. PrunierasC. LapièreC. LapièreC. LapièreM. GreavesM. GreavesM. GreavesM. GreavesH. HönigsmannH. HönigsmannH. Hönigsmann W. J. CunliffeW. J. CunliffeW. J. CunliffeG. L. VejlsgaardG. L. VejlsgaardG. L. Vejlsgaard P. S. FriedmannP. S. FriedmannP. S. FriedmannW. SterryW. Sterry

PAST OFFICERS OF THE ESDR BOARD

YEAR PRESIDENT 1971 F. Serri 1972 O. Braun-Falco 1973 S. Shuster 1974 H. Rorsman 1975 R. Cormane 1976 K. Wolff 1977 E. Jung 1978 E. Christophers 1979 R. Marks 1980 H. Schaefer 1981 E. Frenk 1982 M. Greaves 1983 G. Plewig 1984 W. van Vloten 1985 A. Giannetti 1986 J. H. Saurat 1987 P. Fritsch 1988 W. J. Cunliffe 1989 B. Vermeer 1990 J. Ring 1991 G. L. Vejlsgaard 1992 D. M. MacDonald 1993 G. Stingl 1994 P. S. Friedmann 1995 T. Krieg

YEAR PRESIDENT 1996 W. Sterry 1997 K. Thestrup-Pedersen 1998 R. Camp 1999 P. van de Kerkhof 2000 I. Leigh 2001 G. Zambruno 2002 L. Bruckner-Tuderman 2003 J. Rees 2004 M. Röcken 2005 L. French 2006 T. Schwarz 2007 C. Pincelli 2008 J. McGrath 2009 R. Dummer 2010 E. Healy 2011 V. Piguet 2012 T. Biedermann 2013 A. Enk 2014 N. Reynolds 2015 M. Picardo 2016 J. Barker 2017 M. Schmuth

SECRETARY-TREASURERP. van de KerkhofP. van de KerkhofP. van de KerkhofL. Bruckner-TudermanL. Bruckner-TudermanL. Bruckner-TudermanL. FrenchL. FrenchL. FrenchM. RöckenM. RöckenM. RöckenV. PiguetV. PiguetV. PiguetA. EnkA. EnkJ. BarkerJ. BarkerJ. BarkerM. GillietM. Gilliet

TREASURERR. CormaneR. CormaneR. CormaneR. CormaneE. ChristophersE. ChristophersE. ChristophersT. van JoostW. van VlotenW. van VlotenW. van VlotenW. van VlotenW. van VlotenB. VermeerB. VermeerB. VermeerB. VermeerR. WillemzeR. WillemzeR. WillemzeR. WillemzeR. WillemzeR. WillemzeP. van de KerkhofP. van de Kerkhof

FloorplanES

DR

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ESDR

Ground floor Floor 1

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FLOORPLAN

Mozart Hall 4-5

Reg

istr

atio

n

Mozart Hall 1-3

Papageno Hall

(Sheraton)

Wolf Dietrich

HallSpeakers'preview

room(mezzanine)

Posters

Posters

Exhibition area

Posters

Floor 2 Floor 3

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Europa Hall(Auditorium)

Posters

E-posters (1-9)

E-posters(10-12)

FLOORPLAN

Europa Hall

Europa Hall

(Auditorium)

(Balcony)E-posters (13–20)

Floor 4

7 PATIENT GROUPSWe invite all ESDR2017 delegates to visit Patient Group representatives at their tables in the Exhibition Area. The Patient Groups represented are:European Network for Ichthyosis (ENI) & Pachyonychia Congenita Project

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Europa Hall

Doppler Hall

(Balcony)

1

# Exhibitor1 FibroTx2 ImaBiotech3 TissueGnostics4 European Society for Dermatological Research (ESDR)5 Genoskin6 Biotest

2

3 4

5

6

7

FLOORPLAN

Exhibition Floorplan

Notes

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a website dedicated to rare genetic skin diseases

The aim of the website is to disseminate knowledge about genetic disorders and to improve their diagnosis, treat-ment and care.There is a free access area for patients and general public and restricted access for professionals giving additional information on the diseases.

May 16-19, 2018

Rosen Shingle Creek ResortOrlando, Florida

SAVE THE DATE

www.IID2018.org

Documents

ANNUAL ESDR MEETING · ANNUAL ESDR MEETING. ... 33 Concurrent Session 1: Inflammation, Immunity & Infection 1 ... Speed Dating for pre-registered delegates, Coffee Break