ANNEXURE XI PRE FEASIBILITY REPORTenvironmentclearance.nic.in/writereaddata/Online/TOR/05_Nov_2019... · Diclofenac 2 Guanine 73‐40‐5 Intermediate of Valacyclovir 3 ... acid 2‐methyl

132

ANNEXURE‐XI

PREFEASIBILITYREPORT

For

PROPOSEDMANUFACTURINGOFBULKDRUG&BULKDRUGINTERMEDIATES

PLANT

of

M/s.OZONELIFESCIENCE

PLOTNO‐8006/2,GIDCESTATE,ANKLESHWAR,

DIST‐BHARUCH‐393002GUJARAT

133

CONTENTS

Sr.No. Description PageNo.

1. ExecutiveSummary 17

2. Introduction of the Project/Backgroundinformation

34

3. ProjectDescription 36

4. SiteAnalysis 42

5. PlanningBrief 41

6. ProposedInfrastructure 44

7. Rehabilitationandresettlement(R&R)Plan 45

8. ProjectSchedule&CostEstimates 45

9. AnalysisofProposal(FinalRecommendations) 45

134

1.0 EXECUTIVESUMMARY

1.1CompanyProfile

M/S OZONE LIFE SCIENCE will be involving in manufacturer of bulk drug & bulk drug

IntermediateatPlotNo.8006/2,G.I.D.C.IndustrialEstate,Ankleshwar,Dist:Bharuch(Gujarat).

1.2ProjectDetails1.2.1 ProductsalongwithProductionCapacity

Sr.No. NameoftheProducts CASNo

QuantityMT/Month EndUse

11‐(2,6‐Dichlorophenyl)‐2‐indolinone 15307‐86‐05

20

IntermediateofDiclofenac

2Guanine 73‐40‐5 Intermediateof

Valacyclovir

3(2S)‐2‐aminobutanamideHydrochloride 7682‐20‐4 Intermediateof

Levetiracetam

4 1,1‐Cyclohexanediaceticacidmonoamide 99189‐60‐3 IntermediateofGabapentin

5 3,4‐Dimethoxybenzoicacid(VeratricAcid)

93‐07‐2 IntermediateofMebeverin

6ParaAminoBenzoicAcid 150‐13‐0 Intermediateof

Benzocaine

71‐(2,2‐Dimethoxyethyl)‐1,4‐dihydro‐3‐methoxy‐4‐oxo‐2,5‐pyridinedicarboxylicacid2‐methylester

1335210‐23‐5IntermediateofDolutegravir

8(S)‐1‐(2‐Amino‐5‐chlorophenyl)‐1‐(trifluoromethyl)‐3‐cyclopropyl‐2‐propyn‐1‐ol

209414‐27‐7IntermediateofEfavirenz

9

(S)‐5‐Chloro‐alpha‐(cyclopropylacetenyl)‐2‐[((4‐methoxyphenyl)methyl)amino]‐alpha‐(trifluoromethyl)benzenemethanol

173676‐60‐3

IntermediateofEfavirenz

10(1R,2S,5R)‐Menthyl‐(2R,5S)‐5‐(4‐amino‐2‐oxo‐2H‐pyrimidin‐1‐yl)‐[1,3]oxathiolane‐2‐carboxylicacid

147027‐10‐9IntermediateofLamivudine

11 2‐Amino‐3,5‐dibromobenzaldehyde 50910‐55‐9 IntermediateofAmbroxol

12 Trans‐4‐Aminocyclohexanol 27489‐62‐9 IntermediateofAmbroxol

13DenatoniumBenzoate 3734‐33‐6 Intermediateof

Bitterant

144‐(Aminomethyl)BenzoicAcid 56‐91‐7 Intermediateof

TranexamicAcid

15 1‐(3‐Chlorophenyl)‐4‐(3‐chloropropyl)piperazinehydrochloride

52605‐52‐4 IntermediateofTrazadone

135

Sr.No.

NameoftheProducts CASNo QuantityMT/Month

EndUse

162‐Chloromethyl‐4‐methoxy‐3,5‐dimethylpyridinehydrochloride

86604‐75‐3 IntermediateofOmeprazole

175‐Methoxy‐2‐MercaptoBenzimidazole 37052‐78‐1 Intermediateof

Omeprazole

185‐Difluoromethoxy‐2‐{[(3,4‐dimethoxy‐2‐pyridinyl)methyl]thio}‐1H‐benzimidazole

102625‐64‐9IntermediateofPantoprazole

192‐[[[4‐(3‐MethoxyPropoxy)‐3‐MethylPyridine‐2‐yl]Methyl]Thio]‐1H‐Benzimidazole

117977‐21‐6IntermediateofRabeprazole

20

tert‐Butyl(4R,6R)‐2‐[[[6‐(2‐4‐fluorophenyl)‐5‐isopropyl‐3‐phenyl‐4‐(phenylcarbamoyl)pyrrol‐1‐yl]ethyl]‐2,2‐dimethyl‐1,3‐dioxan‐4‐yl]acetate

125971‐95‐1

IntermediateofAtorvastatin

21

tert‐Butyl6‐[(1E)‐2‐[4‐(4‐fluorophenyl)‐6‐(1‐methylethyl)‐2‐[methyl(methylsulfonyl)amino]‐5‐pyrimidinyl]ethenyl]‐2,2‐dimethyl‐1,3‐dioxane‐4‐acetate

289042‐12‐2

IntermediateofRosuvastatine

22 1‐[2‐Amino‐1‐(4‐methoxyphenyl)ethyl]cyclohexanol

149289‐31‐6 IntermediateofVenlafaxine

232,3‐Dichlorobenzoylcyanide 77668‐42‐9 Intermediateof

Lamotrigine

245‐Chloroacetylsalicylamide 33254‐88‐5 Intermediateof

Labetalol

25 1‐(4‐Chlorobenzhydryl)piperazine 303‐26‐4 IntermediateofCetrizine

26 2‐Amino,5‐methylthiazole 7305‐71‐7 IntermediateofMeloxicam

274‐Hydroxy,2‐methyl,2h,1,2‐benzothiazinecarboxylicacidisopropylester‐1,1‐dioxide

118854‐48‐1IntermediateofMeloxicam

284‐Hydroxy,2‐methyl,2h,1,2‐benzothiazinecarboxylicacidmethylester‐1,1‐dioxide

35511‐15‐0IntermediateofMeloxicam

29ChloroacetylXylidine 1131‐01‐7 Intermediateof

Lidocaine

30

2‐(2‐(3‐(S)‐(3‐(2‐(7‐Chloro‐2‐quinolinyl)‐ethenyl)phenyl‐3‐methanesulphonyloxypropyl)pehenyl)‐2‐propanol

142569‐70‐8

IntermediateofMontelukast

311‐(Mercaptomethyl)‐cyclopropaneaceticacid

162515‐68‐6 IntermediateofMontelukast

32 3‐Morpholino‐1‐(4‐(2‐oxopiperidin‐1‐yl)5,6‐dihydropyridin‐2(1h)‐one

545445‐44‐1 IntermediateofApixaban

33 z‐Ethyl‐2‐chloro‐2‐(2‐(4‐methoxyphenyl)hydrazono)acetate

27143‐07‐3 IntermediateofApixaban

136

Sr.No.

NameoftheProducts CASNo QuantityMT/Month

EndUse

344‐Chloro‐7‐tosyl‐7h‐pyrrolo[2,3‐d]pyrimidine

479633‐63‐1 IntermediateofTofacitanib

35(3R,4R)‐1‐Benzyl‐n,4‐dimethylpiperidin‐3‐amine

477600‐70‐7 IntermediateofTofacitanib

36[(2S)‐1‐tert‐butoxycarbonyl‐4‐oxo‐2‐pyrrolidinylcarbonyl]‐1,3‐thiazolidine

401564‐36‐1 IntermediateofTeneligliptin

37 1‐(3‐methyl‐1‐phenyl‐5‐pyrazolyl)‐piperazine)

401566‐79‐8 IntermediateofTeneligliptin

386‐Chloro4‐Hydroxy2‐Methyl2H‐thieno[2,3,e][1,2]thiazine‐3‐Carboxylate1,1‐dioxide

70415‐50‐8IntermediateofLornoxicam

394,4’‐(2‐Pyridinylmethylene)bisphenol 603‐41‐8 Intermediateof

Bisacodyl

403‐Amino‐4‐methyl‐2‐thiophenecarboxylicacidmethylester

85006‐31‐1 IntermediateofArticaine

TOTAL 20

137

LISTOFRAWMATERIAL&QUANTITY:

Sr.no.

NameoftheProducts NameoftheRawMaterialsCASno./CIno.ofrawmaterials.

ProposedQuantity

(MT/Month)1. 1‐(2,6‐

Dichlorophenyl)‐2‐indolinone

3‐ Indolinone 3260‐61‐5 11.5DichloroPhenol 120‐83‐2 12.5DimethylFormamide 68‐12‐2 26.0

2. Guanine TAPS 29915‐38‐6 20.0

FormicAcid 64‐18‐6 100.0SodiumFormate 141‐53‐7 12.0CausticSodaFlakes 1310‐73‐2 20.00Hyflo 68855‐54‐9 0.25ActivatedCarbon 7440‐44‐0 0.25AceticAcid 64‐19‐7 22.0

3. (2S)‐2‐

aminobutanamideHydrochloride

(2S)‐2‐aminobutanoicacid 1492‐24‐6 20.0Methanol 67‐56‐1 200.0SodiumMethoxide 124‐41‐4 10.0HydrochloricAcid 7647‐01‐0 38.1LiquorAmmonia 1336‐21‐6 20.0

4. 1,1‐Cyclohexanediaceticacidmonoamide

GlacialAceticAcid 64‐19‐7 12.0Cyclohexenone 108‐94‐1 10.0AceticAnhydried 108‐24‐7 12.0

5. 3,4‐Dimethoxybenzoicacid(VeratricAcid)

Catechol 120‐80‐9 7.2DimethylSulphate 75‐18‐3 20.0CaustiSodaFlakes 1310‐73‐2 6.0DichloroMethane(MDC) 75‐09‐2 89.20AluminiumChloride 7446‐70‐0 24.2AcetylChloride 75‐36‐5 15.80ActvatedCarbon 64365‐11‐3 0.20Hyflo 68855‐54‐9 0.06SodiumHydrosulfite 7775‐14‐6 0.20HydrochloricAcid 7647‐01‐0 38.5Sodiumhypochlorite 7681‐52‐9 38.40Sodiummetabisulphite 7681‐57‐4 1.20

6. ParaAminoBenzoicAcid

P‐ NitrobenzoicAcid 62‐23‐7 25.19Pd/C 7440‐05‐3 0.74CausticSoda 1310‐73‐2 7.41Hydrochloricacid 7647‐01‐0 9.19

138

Sr.no.

NameoftheProducts NameoftheRawMaterials

CASno./CIno.ofrawmaterials.

ProposedQuantity(MT/Mont

h)7. 1‐(2,2‐Dimethoxyethyl)‐1,4‐

dihydro‐3‐methoxy‐4‐oxo‐2,5‐pyridinedicarboxylicacid2‐methylester

4‐Methoxyacetoacetate 41051‐15‐4 36.04DMFDMA 4637‐24‐5 29.40Methanol 67‐56‐1 120.00Aminoacetaldehydedimethylacetal

534‐15‐62.00

Dimethyloxalate 553‐90‐2 29.10Lithiumhydride 7580‐67‐8 2.00Lithiumhydroxide 1310‐65‐2 5.90Hydrochloricacid 7647‐01‐0 14.00Ethylaceate 141‐78‐6 300.00Sodiumhydroxide 1310‐73‐2 0.30

8. (S)‐1‐(2‐Amino‐5‐chlorophenyl)‐

1‐(trifluoromethyl)‐3‐cyclopropyl‐2‐propyn‐1‐ol

4‐Chloro‐2‐trifluoroacetylanilinehydrochloride

173676‐59‐020.00

4‐Methoxyphenylmethanol

105‐13‐510.64

Cyclopropylacetylene 6746‐94‐7 5.20Tetrahydrofuran 109‐99‐9 244.00Methyltert‐butylether 1634‐04‐4 120.00Ammonia 7664‐41‐7 1.00Toluene 108‐88‐3 445.00Heptane 142‐82‐5 40.00ActivatedCarbon 7440‐44‐0 1.00DDQ 84‐58‐2 16.60Sodiumbicarbonate 144‐55‐8 2.00Methanol 67‐56‐1 81.00AceticAcid 64‐19‐7 1.50Sodiumchloride 7647‐14‐5 0.90SodiumHydroxide 1310‐73‐2 1.00n‐Hexane 110‐54‐3 50.00Acetone 67‐64‐1 12.00Sodiumborohydride 16940‐66‐2 2.80

9. (S)‐5‐Chloro‐alpha‐(cyclopropylacetenyl)‐2‐[((4‐methoxyphenyl)methyl)amino]‐alpha‐(trifluoromethyl)benzenemethanol

4‐Chloro‐2‐trifluoroacetylanilinehydrochloride

173676‐59‐0 13.33

4‐Methoxyphenylmethanol

105‐13‐5 7.09

Cyclopropylacetylene 6746‐94‐7 3.47Tetrahydrofuran 109‐99‐9 162.67Methyltert‐butylether 1634‐04‐4 80.00Ammonia 7664‐41‐7 0.67Toluene 108‐88‐3 83.33Heptane 142‐82‐5 26.67ActivatedCarbon 7440‐44‐0 0.67

139

Sr.no. NameoftheProducts NameoftheRawMaterialsCASno./CIno.

ofrawmaterials.

ProposedQuantity

(MT/Month)10. (1R,2S,5R)‐Menthyl‐

(2R,5S)‐5‐(4‐amino‐2‐oxo‐2H‐pyrimidin‐1‐yl)‐[1,3]oxathiolane‐2‐carboxylicacid

L‐Menthol 2216‐51‐5 25.00GlyoxalicAcid(50%) 298‐12‐4 10.00SulphuricAcid 7664‐93‐9 0.30Sodiumcarbonate 497‐19‐8 2.00Cyclohexane 110‐82‐7 75.00Sodiumbisulphate 10034‐88‐5 3.50Formaldehyde 50‐00‐0 1.501,4‐Dithiane‐2,5‐diol 40018‐26‐6 4.50AceticAcid 64‐19‐7 2.00n‐Hexane 110‐54‐3 92.00TriethylAmine 121‐44‐8 5.85Toluene 108‐88‐3 155.00Methylsulfonicacid 75‐75‐2 0.15Dimethylformamide 68‐12‐2 0.50Thionylchloride 7719‐09‐7 6.27Cytosine 71‐30‐7 5.85HMDS 999‐97‐3 7.50EthylAcetate 141‐78‐6 35.00

11. 2‐Amino‐3,5‐dibromobenzaldehyde

2‐Amino‐benzoicacidmethylester

134‐20‐312.50

Brominegas 7726‐95‐6 13.21Methanol 67‐56‐1 70.00SodiumBorohydride 16940‐66‐2 2.86Hydrochloricacid 7647‐01‐0 3.05

12. Trans‐4‐Aminocyclohexanol Paracetamol 103‐90‐2 50

Pd/C 7440‐05‐3 2.00HydrogenGas 1333‐74‐0 2.00CausticSoda 1310‐73‐2 13.24Toluene 108‐88‐3 114.60

13. DenatoniumBenzoate Lidocaine 137‐58‐6 10

Toluene 108‐88‐3 40BenzylChloride 100‐44‐7 6CausticSodaFlakes 1310‐73‐2 6BenzoicAcid 65‐85‐0 6

14. 4‐(Aminomethyl)BenzoicAcid

Chlorobenzene 108‐90‐7 88p‐toluicacid 99‐94‐5 30Chlorine 7782‐50‐5 16CausticSoda 1310‐73‐2 8LiquorAmmonia 1336‐21‐6 4SulphuricAcid(50%) 7664‐93‐9 10

140

Sr.no. NameoftheProducts

NameoftheRawMaterials


ProposedQuantity

(MT/Month)15. 1‐(3‐Chlorophenyl)‐4‐(3‐

chloropropyl)piperazinehydrochloride

Xylene 1330‐20‐7 1003‐chloroaniline 108‐42‐9 20.0BCA 979‐88‐4 28.0CausticLye 1310‐73‐2 8.0Acetone 67‐64‐1 240.0PotassiumCarbonate 584‐08‐7 18.01‐ Bromo3‐ chloropropane

109‐70‐6 24.0

Toluene 108‐88‐3 60.0

16. 2‐Chloromethyl‐4‐methoxy‐3,5‐dimethylpyridinehydrochloride

AceticAcid 64‐19‐7 7.543,5Lutidine 591‐22‐0 7.25H2O2 7722‐84‐1 5.80Methanol 67‐56‐1 101.27SulphuricAcid 7664‐93‐9 24.74Nitricacid 7697‐37‐2 14.30Toluene 108‐88‐3 221.36DMS 75‐18‐3 6.96NaOH 1310‐73‐2 14.38Ammoniumpersulphate

7727‐54‐0 16.70

Carbon 7440‐44‐0 1.54SodiumSulphate 7757‐82‐6 4.00Dimethylformamide 68‐12‐2 0.32Thionylchloride 7719‐09‐7 13.00Acetone 67‐64‐1 12.00

17. 5‐Methoxy‐2‐Mercapto

Benzimidazole4‐ Methoxy2‐ Nitroaniline

96‐96‐820.8

SodiumHydroSulphide

16721‐80‐5 41.6

CarbonDisulphide 75‐15‐0 11.0CausticLye 1310‐73‐2 23.6ActivatedCarbon 7440‐44‐0 0.1HydrochloricAcid 7647‐01‐0 20

141

Sr.no.



ProposedQuantity

(MT/Month)18. 5‐Difluoromethoxy‐2‐{[(3,4‐

dimethoxy‐2‐pyridinyl)methyl]thio}‐1H‐benzimidazole

Maltol 118‐71‐8 17.89Dimethylsulphate 77‐78‐1 5.26Potassiumcarbonate 584‐08‐7 0.32Acetone 67‐64‐1 126.32AmmoniumCarbonate 506‐87‐6 13.68Toluene 108‐88‐3 168.42Phosphorousoxychloride 10025‐87‐3 7.37SodiumHydroxide 1310‐73‐2 24.63Methylenedichloride 75‐09‐2 389.47Hydrogenperoxide(30%) 7722‐84 10.53Aceticacid 64‐19‐7 9.47Methanol 67‐56‐1 184.21AceticAnhydride 108‐24‐7 9.47Chloroform 67‐66‐3 42.11Thionylchloride 7719‐09‐7 8.215‐diFluoromethoxy‐2‐mercapto‐benzimidazole

97963‐62‐714.74

19. 2‐[[[4‐(3‐MethoxyPropoxy)‐3‐MethylPyridine‐2‐yl]Methyl]Thio]‐1H‐Benzimidazole

2,3‐Lutidine 583‐61‐9 9.20HydrogenPeroxide(50%) 7722‐84‐1 6.60Nitricacid 7697‐37‐2 6.00Sulphuricacid 7664‐93‐9 7.04Aceticacid 64‐19‐7 3.563‐Methoxy‐1‐Propanol 1589‐49‐7 4.00SodiumHydroxide 1310‐73‐2 7.36Toluene 108‐88‐3 196.00DMSO 67‐68‐5 40.00Aceticanhydride 108‐24‐7 7.80Hydrochloricacid 7647‐01‐0 4.00ThionylChloride 7719‐09‐7 10.60MDC 75‐09‐2 150.00SodiumSulphate 7757‐82‐6 2.002‐Mercaptobenzimidazole 583‐39‐1 10.60

142

Sr.no.



ProposedQuantity

(MT/Month)20. tert‐Butyl(4R,6R)‐2‐[[[6‐(2‐4‐

fluorophenyl)‐5‐isopropyl‐3‐phenyl‐4‐(phenylcarbamoyl)pyrrol‐1‐yl]ethyl]‐2,2‐dimethyl‐1,3‐dioxan‐4‐yl]acetate

tert‐Butyl‐2‐[(4R,6S)‐6‐(cyanomethyl)‐2,2‐dimethyl,1,3‐dioxane‐4‐yl]acetate

124655‐09‐0

10.0

PalladiumCarbon 7440‐05‐3 0.2Methanol 67‐56‐1 81.2Hyflo 68855‐54‐9 0.2HydrogenGas 1333‐74‐0 0.8DimethylCarbonate 616‐38‐6 4.22‐Methyl2‐Butanone 563‐80‐4 4.2Aniline 62‐53‐3 4.2SulfuricAcid 7664‐93‐9 0.2Benzaldehyde 100‐52‐7 4.2PotassiumCarbonate 584‐08‐7 0.8Toluene 108‐88‐3 112.2Acetone 67‐64‐1 21.6FlouroBenzaldehyde 459‐57‐4 4.4ParaTolueneSulfonicacid

6192‐52‐50.4

IPA 67‐63‐0 48.4

21. tert‐Butyl6‐[(1E)‐2‐[4‐(4‐fluorophenyl)‐6‐(1‐methylethyl)‐2‐[methyl(methylsulfonyl)amino]‐5‐pyrimidinyl]ethenyl]‐2,2‐dimethyl‐1,3‐dioxane‐4‐acetate

4‐Fluorobenzaldehyde 459‐57‐4 6.84‐Methyl‐3‐oxo‐pentanoicacidethylester

7152‐15‐08.6

Potassiumhydroxide 1310‐58‐3 3.0MethylIodide 74‐88‐4 7.8Methanol 67‐56‐1 71.0S‐Methylisothiourea 867‐44‐7 4.62,3‐Dichloro‐5,6‐dicyanobenzoquinone

84‐58‐211.0

HMPA 680‐31‐9 13.0MDC 75‐09‐2 103.2Metachloroperoxybenzoicacid

937‐14‐4 15.4

Methylamine 74‐89‐5 1.4Ethanol 64‐17‐5 32.2Methanesulfonylchloride

124‐63‐0 4.6

Sodiumhydride(60%) 7646‐69‐7 0.2Dimethoxyethane 110‐71‐4 38.8Hydrogen 1333‐74‐0 0.08DIBAL‐H 1191‐15‐7 0.2Toluene 108‐88‐3 38.8

143

Sr.no.


CASno./CIno.ofraw

materials.

ProposedQuantity

(MT/Month)

Methyl(3R)‐3‐(tertbutyldimethylsilyloxy)‐5‐oxo‐6‐triphenylphosphoranylidenehexanoate

147118‐35‐2

18.6

Triethylamine 121‐44‐8 2.0N,N‐Dimethylformamide 68‐12‐2 38.8

22. 1‐[2‐Amino‐1‐(4‐

methoxyphenyl)ethyl]cyclohexanol

4‐MethoxyPhenylAcetonitrile 104‐47‐2 13.0Cyclohexanone 108‐94‐1 8.8NaOH 1310‐73‐2 2.4TBAB 1643‐19‐2 1.0Toluene 108‐88‐3 139.6HydrogenGas 1333‐74‐0 0.4

RaneyNickle 12003‐78‐0 1.0

Methanol 67‐56‐1 332.6

23. 2,3‐Dichlorobenzoylcyanide Toluene 108‐88‐3 128SodiumCyanide 143‐33‐9 62,4‐Dichlorobenzylchloride 94‐99‐5 26Hexane 110‐54‐3 48

24. 5‐Chloroacetylsalicylamide Dichloromethane(MDC) 75‐09‐2 323.0Nitrobenzene 98‐95‐3 52.80Aluminiumchloride 7446‐70‐0 36.00Salicylamide 65‐45‐2 18.40Acetylchloride 75‐36‐5 16.00Hydrochloricacid 7647‐01‐0 28.00Methanol 67‐56‐1 5.20Sulfurylchloride 7791‐25‐5 24.60Acetone 67‐64‐1 105.4

25. 1‐(4‐Chlorobenzhydryl)piperazine

p‐ ChloroBenzophenone 134‐85‐0 20.00FormicAcid 64‐18‐6 3.90Hydrochloric Acid 7647‐01‐0 19.96Toluene 108‐88‐3 47.4Piperazine 110‐85‐0 6.04CausticSodaFlakes 1310‐73‐2 6.40

26. 2‐Amino,5‐methylthiazole Propionaldehyde 123‐38‐6 16

Thiourea 62‐56‐6 14HydrochloricAcid 7647‐01‐0 6CausticSodaFlakes 1310‐73‐2 6Toluene 108‐88‐3 20

144

Sr.no.


CASno./CIno.ofraw

materials.

ProposedQuantity

(MT/Month)

27. 4‐Hydroxy,2‐methyl,2h,1,2‐benzothiazinecarboxylicacidisopropylester‐1,1‐dioxide

DimethylFormamide 68‐12‐2 6IsopropylChloroAcetate 105‐48‐6 10SodiumSaccharin 128‐44‐9 26SodiumCarbonate 497‐19‐8 0.88IsopropylAlcohol(IPA) 67‐63‐0 54SodiumMetal 7440‐23‐5 6DimethylSulphate(DMS) 75‐18‐3 8HydrochloricAcid 7647‐01‐0 8

28. 4‐Hydroxy,2‐methyl,2h,1,2‐benzothiazinecarboxylicacidmethylester‐1,1‐dioxide

DimethylFormamide(DMF) 68‐12‐2 8MethylMonoChloroAcetate 96‐34‐4 8SodiumSaccharin 128‐44‐9 30SodiumCarbonate 497‐19‐8 2MDC 75‐09‐2 18Methanol 67‐56‐1 20SodiumMetal 7440‐23‐5 14DimethylSulphate(DMS) 75‐18‐3 8HydrochloricAcid 7647‐01‐0 6

29. ChloroacetylXylidine Toluene 108‐88‐3 46chloroacetylchloride 79‐04‐9 122,6Xylidine 87‐62‐7 14

30. 2‐(2‐(3‐(S)‐(3‐(2‐(7‐Chloro‐2‐quinolinyl)‐ethenyl)phenyl‐3‐methanesulphonyloxypropyl)pehenyl)‐2‐propanol

MethyleneDichloride 75‐09‐2 34(cyclopropane‐1,1‐diyl)dimethanol

39590‐81‐3 16

SodiumCyanide 143‐33‐9 5HydrochloricAcid 7647‐01‐0 22Toluene 108‐88‐3 36

potassiumethanethioate10387‐40‐

3 16

31. 1‐(Mercaptomethyl)‐cyclopropaneaceticacid

3‐[(E)‐2‐(7‐chloroquinolin‐2‐yl)ethenyl]benzaldehyde

120578‐03‐2

14

TetraHydrofurane 109‐99‐9 26Vinylmagnesiumbromide 1826‐67‐1 6DimethylFormamide 68‐12‐2 282‐(2‐chlorophenyl)propan‐2‐ol

3670‐15‐3 8

145




ProposedQuantity

(MT/Month)32. 3‐Morpholino‐1‐(4‐(2‐

oxopiperidin‐1‐yl)5,6‐dihydropyridin‐2(1h)‐one

Aniline 62‐53‐3 18Dichloromethan(MDC) 75‐09‐2 294CausticSodaFlakes 1310‐73‐2 85‐chlorovalerylchloride 1575‐61‐7 18Toluene 108‐88‐3 98Hexane 110‐54‐3 108SulphuricAcid 7664‐93‐9 0.24NitricAcid 7697‐37‐2 4SodiumBicarbonate 144‐55‐8 18DimethylFormamide 68‐12‐2 40Morpholine 110‐91‐8 4Ethanol 64‐17‐5 90RaneyNickel 12003‐78‐0 2HydrazineHydrate 7803‐57‐8 2EthylAcetate 141‐78‐6 134PhosphorusPentachloride 10026‐13‐8 12

33 z‐Ethyl‐2‐chloro‐2‐(2‐(4‐

methoxyphenyl)hydrazono)acetate

P‐Anisidine 104‐94‐9 18HydrochloricAcid 7647‐01‐0 6SodiumNitrite 7632‐00‐0 6Ethyl2‐ChloroAcetoAcetate

609‐15‐4 12

Methanol67‐56‐1 118

IsopropylAlcohol(IPA) 67‐63‐0 78

34. 4‐Chloro‐7‐tosyl‐7h‐pyrrolo[2,3‐d]pyrimidine

Acetone 67‐64‐1 444‐Chloropyrrolo‐7H‐[2,3,D]Pyrimidine

3680‐69‐1 11

p‐Toluenesulphonicchloride

98‐59‐9 13

CausticSodaFlakes 1310‐73‐2 3

146




ProposedQuantity

(MT/Month)35. (3R,4R)‐1‐Benzyl‐n,4‐

dimethylpiperidin‐3‐amine

Acetone 67‐64‐1 1723–Amino4–MethylPyridine

3430‐27‐176

Acetylchloride 75‐36‐5 4CausticSodaLye 1310‐73‐2 2Toluene 108‐88‐3 230BenzylChloride 100‐44‐7 6Methanol 67‐56‐1 134SodiumBorohydrate 16940‐66‐2 2HydrochloricAcid 7647‐01‐0 10Hexane 110‐54‐3 84CausticSoda 1310‐73‐2 6Methylamine 74‐89‐5 2Di‐ P‐ ToluoylL‐ Tartaricacid

32634‐66‐510

36. [(2S)‐1‐tert‐butoxycarbonyl‐4‐oxo‐2‐pyrrolidinylcarbonyl]‐1,3‐thiazolidine

(2S,4R)‐1‐(tert‐butoxycarbonyl)‐4‐hydroxypyrrolidine‐2‐carboxylicacid

13726‐69‐7

16.0

MethyleneDichloride 75‐09‐2 20.41,3‐thiazolidine 504‐78‐9 6.2

37. 1‐(3‐methyl‐1‐phenyl‐5‐pyrazolyl)‐piperazine)

tert‐butylpiperazine‐1‐carboxylate

57260‐71‐6 16.6

DimethylFormamide 68‐12‐2 33.4Diketene 674‐82‐8 7.0EthylAcetate 141‐78‐6 25.0Pyridine 110‐86‐1 45.0Phenylhydrazine 100‐63‐0 9.2HydrochloricAcid 7647‐01‐0 5.4SodiumCabonate 497‐19‐8 6.2

38. 6‐Chloro4‐Hydroxy2‐Methyl2H‐

thieno[2,3,e][1,2]thiazine‐3‐Carboxylate1,1‐dioxide

Methanol 67‐56‐1 86SodiumMetal 7440‐23‐5 4Methyl5‐chloro‐3‐[(2‐methoxy‐2‐oxoethyl)sulfamoyl]thiophene‐2‐carboxylate

70374‐38‐8

22

HydrochloricAcid 7647‐01‐0 20Toluene 108‐88‐3 52DimethylSulphate 75‐18‐3 8CausticsodaLye 1310‐73‐2 16

147

Sr.no.


CASno./CIno.ofraw

materials.

ProposedQuantity

(MT/Month)

39. 4,4’‐(2‐Pyridinylmethylene)bisphenol

EthylAcetate 141‐78‐6 38Phenol 108‐95‐2 14SulphuricAcid 7664‐93‐9 16CausticSoda 1310‐73‐2 6Pyridine2‐Aldehyde 1121‐60‐4 14Methanol 67‐56‐1 2

40. 3‐Amino‐4‐methyl‐2‐thiophenecarboxylicacidmethylester

4‐methylthiophen‐3‐amine ‐‐ 15MethyleneDichloride 75‐09‐2 37.6MethylChloroformate 79‐22‐1 12.6

148

1.3 WaterRequirementandWastewaterGeneration&Treatment

Sr.No.

Usage WaterConsumption(KL/Day)

WasteWaterGeneration(KL/Day)

1 Industrial Process 11.1 14.9

Boiler 2.0 0.6

Cooling 4.0 0.8

Washing 2.5 2.5

Scrubber 1.4 1.8

TotalIndustrial(A) 21 20.6

2 Domestic(B) 1.0 0.8

3 Gardening(C) 2.5 0.0

Total(A+B+C) 24.5 21.4

SourceofwaterwillbemetthroughGIDCWaterSupply.

Totalproposedwaterrequirementwillbe24.5KLD(Industrial‐21KLD+Domestic

‐1.0KLD+Gardening‐2.5KLD)

Total proposedwastewater generation from the industrial purposedwill be20.6

m3/day

18.8m3/dayshallbetreatedintoETPplantandsendtoCETPofM/sAWML,

Ankleshwarfurthertreatment&finaldisposal

1.8m3/dayScrubbingMediaReuseinplantPremises&Selltoenduserwho

ishavingRule‐9Permission.

0.8KLDtotalproposeddomesticwastewaterwillbesenttoSepticTank&SoakPit.

149

1.4 AirPollutionSourceandControlManagement

ThesourceofairpollutionduetotheprojectwillbeFluegasemission&ProcessVents.

FlueGasEmission:‐

ParticularsStackHeight

FuelUsedWithQty.

ParameterWithPermissibleLimit APCM

Boiler(Cap.‐1.0MT/Hr)

30MBriquetteofBio

Coal3MT/Day

SPM‐150mg/Nm3

SO2‐100ppmNOx‐50ppm

MulticycloneSeparatorWithBagFilter

D.G.Sets(Standby)(Cap.‐125KVA)

9M HSD200Liter/Day

AdequateStackHeight

ProcessGasVent:‐

Sr.No. StackAttachedTo

StackHeight

AirPollutionControlSystem Parameter

PermissibleLimit

1ProcessVent‐1(Chlorination&Sulphonation)

11mTwostageScrubber

(Water+Alkali)

HCl

SO2

20mg/Nm3

40mg/Nm3

2ProcessVent‐2(ProductNo.31–

Br2)11m

TwoStageWaterScrubber Br2 20mg/Nm3

1.5 DetailsofHazardousWasteManagement

Sr.no.

Type/NameofHazardouswaste

Sourceofgeneration

CategoryandScheduleasperHWRules.

Quantity(MT/Annum) DisposalMethod

1 ETPSludge ETP SCH‐I/35.3 20MT/Year

Collection, Storage,Transportation andDisposal at common TSDFsite.

2 DiscardedDrums/Bags/Liners

RawMaterials/Products

SCH‐I/33.1 20MT/Year

Collection, Storage,Transportation,Decontamination & Sale toGPCB approved vendors/reuse /send back tosupplier.

3 Used/SpentOil

Machineries/Utility

SCH‐I/5.1 0.01MT/Year

Collection, Storage,Disposal by reuse in plantmachinery as lubricant ortransportation & Sale toGPCB registered re‐processor.

4 DistillationResidue

Distillation SCH‐I/20.3 82.8MT/Year

Collection, Storage,Transportationandsentforco‐processing in cementindustries or Disposal atcommonincinerationsite.

150

Sr.no.

Type/NameofHazardouswaste

Sourceofgeneration

CategoryandScheduleasperHWRules.

Quantity(MT/Annum) DisposalMethod

5 SpentSolvent Process SCH‐I/28.6 11237MT/Year

Collections, Storage,distillation and reuse inplantpremises.

6 Organicwaste ProcessResidue



7 SpentCarbon Process(ProductNo.8)



8 SpentCatalyst Process(ProductNo.32)


Collection,Storage,reuseinthe plant premises orTransportationandsendtoregenerator.

9 HBr(30%) Scrubber SCH‐I/28.1 132MT/Year

Collection, Storage,Transportation and Sell toend user who is havingRule‐9Permission.

10 Dil.HCl(28%) Scrubber SCH‐II/B15 475MT/Year

Collection, Storage andreuse in plant premises.(Requirement of HCL inProduct No. 5 – 427MT/Year) and remainingsell to end user who ishavingRule‐9Permission.

11 Dil.SodiumbiSulfate(28%)

Scrubber SCH‐II/B15 24MT/Year

Collection, Storage,Transportation and Sell toend user who is havingRule‐9Permission.

12 OffSpecificationProducts

From mfg.Process(Batchfailure)



151

2.0 INTRODUCTIONOFTHEPROJECT/BACKGROUNDINFORMATION

2.1 Identificationof theprojectandprojectproponent. In caseofminingproject,a

copyofmininglease/letterofintentshouldbegiven.

Identificationoftheproject

M/SOZONELIFESCIENCEwillbe involving inmanufacturerofbulkdrug&bulkdrug

Intermediate at Plot No. 8006/2, G.I.D.C. Industrial Estate, Ankleshwar, Dist: Bharuch

(Gujarat).

Identificationoftheprojectproponent

Presentlyfollowingarethepartnersofthecompany:‐

Sr.No. NameofPartners Address

1. Mr.SamirkumarManharlalPatel LimdaFaliya,Gothan,Surat‐394130.

2. Mrs.BinabenSamirkumarPatel LimdaFaliya,Gothan,Surat‐394130.

3. Mr.AshvinbhaiBalubhaiPatel PatelFaliyu,Jokha,Surat‐394326

4. Mr.BhavikkumarAshvinbhaiPatel PatelFaliyu,Jokha,Surat‐394326

5. Mr.ShaileshNagjibhaiPatel B‐401,ShantideepResi.,NearT.G.B.Restaurant,L.P.SavaniRoad,Adajan,Surat‐395009

6. Mr.AshokbhaiLabhubhaiDhameliya 203,JolyAvenue,LambeHanumanRoad,Opp.TrikamnagarChopati,Surat‐395010

7. Mr.KeyurkumarShantibhaiBharodiya B‐204,SilverGreen,AbhilashaHeights,Amroli,Surat‐394105

8. Mr.JitendrabhaiBabubhaiPatel 19,KrishnaParkSoc.,BehindG.I.LColony,GIDC,Ankleshwer,Dist‐Bharuch‐393001

9. Mr.DilipbhaiZinabhaiPatel 305,HappyResi.,500QTRSRoad,GIDC,Ankleshwer,Dist‐Bharuch‐393001

2.2 BriefdescriptionofnatureoftheProject

Proposemanufacturerofbulkdrug&bulkdrugIntermediateunit.

152

2.3 Needfortheprojectanditsimportancetothecountryandorregion

Thedemand forproducts intended tobemanufacture is increasing in the countryby

expanding this unit, company will be able to meet the demand of various products

locally.Theprojectwillsaveforexascertainproductsimportwillbereduced.Thiswill

alsogeneratedirectandindirectemploymentopportunityforvariouslevelsofpeople.

2.4 Demands‐SupplyGap

Based on our informal survey of themarketwith our current customers and various

traders,wehavefoundthatthereisabigpotentialfortherangeoftheproductsweare

planning.Theseproductswillbeanadditiontothecurrentrangeofourproductsofthe

group.

2.5 Importsvs.Indigenousproduction

Basedonthecurrentcostofindigenousrawmaterialsandthenonavailabilityofsome

materials,wewillhavetoimportsomeofthekeyrawmaterialsastheyarenotavailable

indigenously. This will make us very competitive against imported finished products

andwewillbeabletoincreasetheexportofourfinishedproducts.

2.6 Exportpossibility

Thereisexportpotentialforourproposedproducts.

2.7 Domestic/ExportMarkets

Thereisexportpotentialaswellasdemandinlocalmarket.

2.8 EmploymentGeneration(DirectandIndirect)duetoproject.

Employmentwouldbeasperprevailingnormsofstategovernmentforskilled,semi‐

skilledandunskilledpeoplefortheproposedproject.(Direct‐10Nos.&Indirect‐15

Nos.)

153

3.0 PROJECTDESCRIPTION

3.1 TypeofProjectincludinginterlinkedandinterdependentprojects,ifany.

No interlinkedprojecthasbeensubmitted. Proposemanufacturerofbulkdrug&bulk

drugIntermediateunitinCategory:B5(f)

3.2 Location(mapshowinggenerallocation,specificlocationandprojectboundary&

projectsitelayout)withcoordinates.

Mapshowinggenerallocation

PROJECT SITE

154

Specificlocationandprojectboundary

ProjectSite(GoogleMap)

155

Planlayout:

156

3.3 Detailsofalternatesitesconsideredandthebasisofselectingtheproposedsite,

particularlytheenvironmentalconsiderationsgoneintoshouldbehighlighted.

Majorfactorsinvolvedintheselectionofsitearelistedbelow:

Siteisverywellconnectedbyroad

ProximitytoRawMaterialsuppliers

Availabilityofsufficientlandfreefromcultivation

Availabilityofpowerevacuationfacilities

Availabilityofwaterforindustrialuse

AvailabilityofCHWIF,CETP&TSDF

Modern infrastructure support and amenities at par with industrial estates in other global

markets,including:

Efficienttransportfacilitieswithintheindustrialestateandto&fromthecityarea.

Environment‐friendlyzone.

Uninterruptedpowersupply.

3.4 SizeorMagnitudeofOperation

PleasereferAnnexure‐IofForm‐I.

3.5 Project Description with process details (a schematic diagram/flow chart

showingtheprojectlayout,componentsoftheprojectetc.shouldbegiven)

PleasereferAnnexure‐IIIinForm‐I.

3.6 Rawmaterial requiredalongwithestimatedquantity, likely source,marketing

areaoffinalproducts.Modeoftransportofrawmaterialsandfinishedproducts.

PleasereferAnnexure‐IinForm‐I

3.7 Resource optimization/recycling and reuse envisaged in the project, if any,

shouldbebrieflyoutlined.

Companywillexplorethepossibilityofreuse.

157

3.8 Availabilityofwateritssource,energy/powerrequirementandsourceshouldbe

given.

Powerrequirement:‐Electricity‐100KW(DGVCL)(Proposed)

D.G.Set(StandBy)‐1x125KVA(Proposed)

FuelRequirement:‐

BriquettesofBio‐Coal‐3.0MT/Day(Proposed)

HSD‐200Liter/Day(Proposed)

WaterSource:‐

SourceofwaterwillbemetthroughGIDCWaterSupply.

Totalproposedwaterrequirementwillbe24.5KLD(Industrial–21KLD+Domestic‐

1.0KLD+Gardening–2.5KLD)

3.9 Quantity of wastes to be generated (liquid and solid) and scheme for their

management/disposal.

WasteWaterGeneration:‐

Total proposedwastewater generation from the industrial purposedwill be20.6

m3/day

18.8m3/dayshallbetreatedintoETPplantandsendtoCETPofM/sAWML,

Ankleshwarfurthertreatment&finaldisposal

1.8m3/dayScrubbingMediaReuseinplantPremises&Selltoenduserwho

ishavingRule‐9Permission.

0.8KLDtotalproposeddomesticwastewaterwillbesenttoSepticTank&SoakPit.

SolidWaste:

PleasereferSection1.5,PageNo.74‐75inPre‐FeasibilityReport.

158

3.10 Schematic representations of the feasibility drawingwhich give information of

EIApurpose.

RECONNAISSANCE SURVEY OF EXISTING PLANT ANNUAL REPORT MARKET ASSESSMENT FINANCIAL REPORT PROJECT REPORT

INTRODUCTION

MONITORING OF AIR, WATER & SOIL QUALITY & NOISE LEVELS. DATA ON METEOROLOGY SOCIO‐ECONOMIC STATUS & BASIC AMENITIES. SITE VISITS BY AND INTERVIEWS WITH LOCALS

BASELINE ENVIRONMENTAL

STATUS

ENVIRONMENTAL INFORMATION CENTRE CENTRAL GROUND WATER BOARD GUJARAT POLLUTION CONTROL BOARD (GPCB) PUBLIC HEALTH ENGINEERING DEPT. AGRICULTURE DEPARTMENT FOREST DEPARTMENT IRRIGATION DEPARTMENT EMPLOYMENT EXCHANGE HEALTH CENTER CENSUS DEPT. INDIAN METEOROLOGICAL DEPT.

SOCIOECONOMIC STATUS &

INFRASTRUCTURE

PROPOSED EXPANSION PLANT

FACILITY DESCRIPTION

IMPACTS METHODOLOGY OF

IMPACT ASSESSMENT

IDENTIFICATION & ASSESSMENT OF IMPACTS EVALUATION OF IMPACTS BY MATRIX METHOD

SOURCE OF INFORMATION OVERVIEW OF E. I. A. STUDIES

ACTIVITIES

ENVIRONMENTAL MANAGEMENT PLAN

DESCRIPTION OF EFFLUENT TREATMENT PLAN, AIR POLLUTION CONTROL, HAZARDOUS WASTE MANAGEMENT, GREEN BELT DEVELOPMENT MONITORING PROGRAM

RISK ANALYSIS STUDIES & DISASTER

MANAGEMENT PLAN

SAFETY, HEALTH & ENVIRONMENTAL POLICY, GUIDELINES BY DIRECTOR GENERAL OF FACTORY SAFETY, MINISTRY OF LABOR. CONSEQUENCE ANALYSIS

PREPARATION OF DISASTER MANAGEMENT PLAN

159

4.0 SITEANALYSIS

4.1 Connectivity

Siteisverywellconnectedbyroad&rail

Availabilityofpowerevacuationfacilities

Availabilityofwaterforindustrialuse

4.2 LandForm,LandUseandLandOwnership

ItwillbeincorporatedinEIAStudies.

4.3 Topography(alongwithmap)

WewillincorporatetopographyinEIAStudies.

4.4 Existing land use pattern (agriculture, non‐agriculture, forest, water bodies

(includingareaunderCRZ)),shortestdistancesfromtheperipheryoftheproject

toperipheryoftheforests,nationalpark,wildlifesanctuary,ecosensitiveareas,

water bodies (distance from HFL of the river), CRZ. In case of the notified

industrialarea,acopyoftheGazettenotificationshouldbegiven.


4.5 ExistingInfrastructure

ExistinglandhavingAdm.Bldg.,Godown,etcanditwillbeclearedorreconstructafter

gettingnecessarypermission.

4.6 SoilClassification


4.7 Climaticdatafromsecondarysources.

Primarysource:ourownweatherstation&SecondarySources:IndianMeteorological

Department,Ahmedabad.

4.8 Socialinfrastructureavailable.

Dependingonthegrowthofthecompanytherequiredsocialinfrastructurewillbeprovided.

160

5.0 PLANNINGBRIEF

5.1 Planning Concept (type of industries, facilities, transportation, etc.) Town and

Countryplanning/Developmentauthorityclassification.

TypeofIndustry:BulkDrug&BulkDrugIntermediateManufacturingUnit.

5.2 PopulationProjection


5.3 Landuseplanning(breakupalongwithgreenbelt,etc.)

Sr.No. Description Sq.Meter

1 ProductionArea 1862 Raw Material & Finish Product

StorageArea400

3 Haz.WasteStorageArea 1004 Boiler&Utility 705 ETP 506 Admin&LabBuilding 608 HydrogenGas StorageArea 2010 GasStorageArea 2011 GreenBeltArea(30.76%) 60012 Parking 9613 Road&OpenArea 340.1214 SecurityCabin 8

TOTAL 1950.12

5.4 AssessmentofInfrastructureDemand(Physical&Social)


5.5 Amenities/Facilities


161

6.0 PROPOSEDINFRASTRUCTURE

6.1 IndustrialArea(ProcessingArea)

ProcessingArea(ProcessingZone,ETPAreaandBoiler&UtilityArea):306m2

6.2 ResidentialArea(NonProcessingArea)

Non Processing Area (Green belt, Raw material storage area, Finished storage area,

road,OpenArea):1644.12m2

6.3 GreenBelt

Total 1950.12 sq. meter land area is available at site; out of this area about 600 sq.

meter(30.76%)areawillbedevelopedasgreenbeltandotherformsofgreenery.

6.4 SocialInfrastructure

Depending on the growth of the company the required social infrastructure will be

provided.

6.5 Connectivity(TrafficandTransportationRoad/Rail/Metro/Waterways,etc.)

Siteisverywellconnectedbyroad&railway.

6.6 DrinkingwaterManagement(Source&Supplyofwater)

WaterrequirementwillbemetthroughGIDCwatersupply.

6.7 SewerageSystem

Sewagepipesare laid in entire company for the removalanddisposalofmainlynon‐

harmful liquid wastes from the offices, canteen and domestic waste coming from

differentsections.Theseliquidwastesaredisposedbyseptictankandsoakpit.

6.8 SolidWasteManagement

PleasereferSection1.5,PageNo.74‐75inPre‐FeasibilityReport.6.9 PowerRequirement&Supply/Source

PleasereferSection3.8,PageNo.82inPre‐FeasibilityReport.

162

7.0 REHABILITATIONANDRESETTLEMENT(R&R)PLAN

7.1 Policy tobeadopted (central/state) in respectof theprojectaffected including

homeousters,landoustersandlandlesslaborers(abriefoutlinetobegiven)

There is nohabitationon theproposedproject area and it is industrial landwhich is

purchased by company for development of Company, so that R & R policy is not

applicable to thisproject.Thereshallbenodisplacementofanypopulation inproject

area.

8. PROJECTSCHEDULE&COSTESTIMATES

8.1 Likelydateofstartofconstructionandlikelydateofcompletion(Timeschedule

fortheprojecttobegiven).

We shall start construction after getting environmental clearance and consent to

establish.WeshallstartproductionuponmakingapplicationforCCA.

8.2 EstimatedProject costalongwithanalysis in termsofeconomicviabilityof the

project.

TotalcostsoftheprojectwillRs.4.85Crore.Capitalcostofair&waterpollutioncontrol

systemandenvironmentalmonitoringequipmentswillbeRs.25Lakh.

9. ANALYSISOFPROPOSAL(FINALRECOMMENDATIONS)

9.1 Financial and social benefitswith special emphasis on the benefit to be local

peopleincludingtribalpopulation,ifany,inthearea.

Employmentwouldbeasperprevailingnormsofstategovernment forskilled

andunskilledpeoplefortheproposedproject.

SocialWelfareshallbedone.

Cordialrelationwiththeindustryshallbeestablishedandrepresentationshall

bemadetovillagersforhelpforcreationoffacilitiesrelatedtohealth,education,

etc.

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ANNEXURE XI PRE FEASIBILITY REPORTenvironmentclearance.nic.in/writereaddata/Online/TOR/05_Nov_2019... · Diclofenac 2 Guanine 73‐40‐5 Intermediate of Valacyclovir 3 ... acid 2‐methyl