Annalsof the Rheumatic Diseases January 1988

Annals of the Rheumatic Diseases January 1988 Vol. 47 No. 1

ContentsPage

Conditioned medium from stimulated mononuclear leucocytes potentiates the ability of humanneutrophils to damage human articular cartilage EDNA J BATES, INGEBORG C KOWANKO, ANDANTONIO FERRANTE 1

Circulating inhibitor bound elastase in patients with ankylosing spondylitis and rheumatoidarthritis and the influence of sulphasalazine treatment NILS FELTELIUS AND ROGER HALLGREN 10

Effects of chrysotherapy on circulating lymphocyte numbers and subsets M D SMITH, A SMITH, M FEHR,M J AHERN, AND P J ROBERTS-THOMSON 15

Measurement of 'free' gold in patients receiving disodium aurothiomalate and the association of highfree to total gold levels with toxicity M J HEATH 18

Autoimmunity to La (SS-B) in vitro is related to HLA-DR3 in healthy subjects PATRICK J W VENABLES,SHIRLEY RIGBY, PAT A MUMFORD, JOHN MARKWICK, AND RAVINDER N MAINI 22

Pulse steroid therapy in rheumatoid arthritis: Can equivalent doses of oral prednisolone give similarclinical results to intravenous methylprednisolone? MALCOLM D SMITH, MICHAEL J AHERN, ANDPETER J ROBERTS-THOMSON 28

Synovial fluid neutrophils of patients with rheumatoid arthritis have membrane antigen changes thatreflect activation PAUL EMERY, ANGEL F LOPEZ, GORDON F BURNS, AND MATHEW A VADAS 34

Comparison of sleep in osteoarthritic patients and age and sex matched healthy controls T J LEIGH,I HINDMARCH, H A BIRD, AND V WRIGHT 40

Infusion of Iloprost, a prostacyclin analogue, for treatment of Raynaud's phenomenon in systemicsclerosIS N J MCHUGH, M CSUKA, H WATSON, G BELCHER, A AMADI, E F J RING, C M BLACK, ANDP J MADDISON 43

Kinetic investigations into the possible cause of low serum histidine in rheumatoid arthritisN G SITrON, J S DIXON, C ASTBURY, R J FRANCIS, H A BIRD, AND V WRIGHT 48

Sequential nailfold capillary microscopy in scleroderma and related disorders M L WONG, J HIGHTON,AND D G PALMER 53

Computed tomographic demonstration of calcification of the ligamenta flava of the lumbosacral spinein ankylosing spondylitis ELIESER AVRAHAMI, IRENA WIGLER, DORIT STERN, DAN CASPI, ANDMICHAEL YARON 62

Low free testosterone levels in rheumatoid arthritis T D SPECTOR, L A PERRY, G TUBB, A J SILMAN, ANDE C HUSKISSON 65

Effect of dietary restrictions on disease activity in rheumatoid arthritis DEEPA BERI, A N MALAVIYA,RENU SHANDILYA, AND R R SINGH 69

Trauma and seronegative spondyloarthropathy: rapid joint destruction in peripheral arthritistriggered by physical injury IGNAZIO OLIVIERI, SANDRA GHERARDI, CHIARA BINI, DONATELLA TRIPPI,MARIA LAURA CIOMPI, AND GIAMPIERO PASERO 73

Acute pancreatitis in systemic lupus erythematosus: report of a case unrelated to drug therapyROGER WOLMAN, CHRISTOPHER DE GARA, AND DAVID ISENBERG 77

Severe myalgia in familial Mediterranean fever: clinical and ultrastructural aspects D SCHAPIRA,R LUDATSCHER, M NAHIR, M LORBER, AND Y SCHARF 80

Correspondence 84

Book reviews 85

Notes 87

Acknowledgments 88

ASTMS CODEN: ARDIAO 47 (1) 1-88 (1988) ISSN 0003-4967

British Medical Association Tavistock Square London WC1H 9JR

Published bv British Medical Association. Tasistock Square. London WC IH 9JR. and

printed in England bh The Devonshirc Prcss Ltdi. TorquaN

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CONTENTS OF VOLUME 47

No. 1 January, 1988Conditioned medium from stimulated mononuclear leucocytes poten-

tiates the ability of human neutrophils to damage human articularcartilageEdna J. Bates, Ingeborg C. Kowanko, and Antonio Ferrante 1

Circulating inhibitor bound elastase in patients with ankylosing spondy-litis and rheumatoid arthritis and the influence of sulphasalazinetreatment

Nils Feltelius and Roger Hallgren 10Effects of chrysotherapy on circulating lymphocyte numbers and

subsetsM. D. Smith, A. Smith, M. Fehr, M. J. Ahern, and P. J. Roberts-Thomson 15

Measurement of 'free' gold in patients receiving disodium aurothio-malate and the association of high free to total gold levels withtoxicityM. J. Heath 18

Autoimmunity to La (SS-B) in vitro is related to HLA-DR3 in healthysubjects

Patrick J. W Venables, Shirley Rigby, Pat A. Mumford, JohnMarkwick, and Ravinder N. Maini 22

Pulse steroid therapy in rheumatoid arthritis: Can equivalent doses oforal prednisolone give similar clinical results to intravenousmethylprednisolone?Malcolm D. Smith, Michael J. Ahern, and Peter J. Roberts-Thomson 28

Synovial fluid neutrophils of patients with rheumatoid arthritis havemembrane antigen changes that reflect activation

Paul Emery, Angel F. Lopez, Gordon F. Burns, and Mathew A.Vadas 34

Comparison of sleep in osteoarthritic patients and age and sex matchedhealthy controls

T. J. Leigh, L. Hindmarch, H. A. Bird, and V. Wright 40Infusion of lloprost, a prostacyclin analogue, for treatment of Raynaud's

phenomenon in systemic sclerosisN. J. McHugh, M. Csuka, H. Watson, G. Belcher, A. Amadi,E. F. J. Ring, C. M. Black, and P. J. Maddison 43

Kinetic investigations into the possible cause of low serum histidine inrheumatoid arthritis

N. G. Sitton, J. S. Dixon, C. Astbury, R. J. Francis, H. A. Bird, andV. Wright 48

Sequential nailfold capillary microscopy in scleroderma and relateddisordersM. L. Wong, J. Highton, and D. G. Palmer 53

Computed tomographic demonstration of calcification of the ligamentaflava of the lumbosacral spine in ankylosing spondylitis

Elieser Avrahami, Irena Wigler, Dorit Stern, Dan Caspi, andMichael Yaron 62

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Low free testosterone levels in rheumatoid arthritisT. D. Spector, L. A. Perry, G. Tubb, A. J. Silman, and E. C. Huskisson 65

Effect of dietary restrictions on disease activity in rheumatoid arthritisDeepa Beri, A. N. Malaviya, Renu Shandilya, and R. R. Singh 69

Trauma and seronegative spondyloarthropathy: rapid joint destructionin peripheral arthritis triggered by physical injury

Ignazio Olivieri, Sandra Gherardi, Chiara Bini, Donatella Trippi,Maria Laura Ciompi, and Giampiero Pasero 73

Acute pancreatitis in systemic lupus erythematosus: report of a caseunrelated to drug therapyRoger Wolman, Christopher de Gara, and David Isenberg 77

Severe myalgia in familial Mediterranean fever: clinical and ultra-structural aspects

D. Schapira, R. Ludatscher, M. Nahir, M. Lorber, and Y. Scharf 80Correspondence 84Book reviews 85Notes 87Acknowledgments 88

No. 2 February, 1988Leading article: A possible immunochemical explanation for pregnancy

associated remissions in rheumatoid arthritis?D. R. Stanworth 89

Alterations in carbohydrate composition of serum IgG from patients withrheumatoid arthritis and from pregnant women

J. M. Pekelharing, Ellen Hepp, J. P. Kamerling, G. J. Gerwig, andB. Leiinse 91

Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoidarthritis: a double blind placebo controlled study

J. J. F. Belch, D. Ansell, R. Madhok, A. O'Dowd, and R. D. Sturrock 96Large quantities of low molecular weight IgM in mixed cryoglo-

bulinaemiaP. J. Roberts-Thomson, Alison Kennedy, and Lin Y. Koh 105

Anticardiolipin antibodies, livedo reticularis, and major cerebrovascularand renal disease in systemic lupus erythematosus

N. J. McHugh, J. Maymo, R. P. Skinner, I. James, and P. J. Maddison 110Serum amino terminal type Ill procollagen peptide and serum hyaluronan

in rheumatoid arthritis: relation to clinical and serological parametersof inflammation during 8 and 24 months' treatment with levamisole,penicillamine, or azathioprine

K. H0rslev-Petersen, K. D. Bentsen, A. Engstrom-Laurent, P. Junker,P. Halberg, and I. Lorenzen 116

Cyclosporin in rheumatoid arthritis: a double blind, placebo controlledstudy in 52 patientsMaxime Dougados, Hassane Awada, and BernardAmor 127

Salicylate ototoxicity in patients with rheumatoid arthritis: a controlledstudyJames T. Halla and Joe G. Hardin 134

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Analysis of clinical judgment helps to improve agreement in the assess-ment of rheumatoid arthritis

J. R. Kirwan, C. G. Barnes, P. G. Davies, and H. L. F. Currey 138Does active rheumatoid arthritis affect intestinal iron absorption?

H. -P. Benn, J. Drews, G. Randzio, J. M. Jensen, and H. Loffler 144The arthritis sufferer and the community: a comparison of arthritis

sufferers in rural and urban areasPaul G. L. Cornelissen, JohannesJ. Rasker, andHansA. Valkenburg 150

Behcet's disease associated with amyloidosis in Turkey and in the worldN. DilEen, M. Konige, 0. Aral, T. Erbengi, V. Uysal, N. Kogak, andE. Ozdogan 157

Pattern of Lyme arthritis in Europe: report of 14 casesJ. P. Huaux, G. Bigaignon, S. Stadtsbaeder, P. F. Zangerle, andC. Nagant de Deuxchaisnes 164

Sarcoidosis in a patient presenting with clinical and histological featuresof primary Sjogren's syndrome

R. D. Melsom, P. M. Speight, J. Ryan, and J. D. Perry 166Viewpoint: Do diets rich in polyunsaturated fatty acids affect disease

activity in rheumatoid arthritis?L. Gail Darlington 169

Correspondence 173Book reviews 175

No. 3 March, 1988Special announcements 177Review: Autoantibody profile in juvenile chronic arthritis

Alison M. Leak 178Value of joint scintigraphy in the prediction of erosiveness in early

rheumatoid arthritisT. T. Mottonen, P. Hannonen, J. Toivanen, A. Rekonen, andM. Oka 183

Relation between synovial fluid C3 degradation products and localinflammation in rheumatoid arthritis, osteoarthritis, and crystalassociated arthropathyMichael Doherty, Nora Richards, June Hornby, and RichardPowell 190

Bone resorbing activity in synovial fluids in destructive osteoarthritisand rheumatoid arthritis

W. H. Alwan, P. A. Dieppe, C. J. Elson, and J. W. B. Bradfield 198A search for retrovirus infection in systemic lupus erythematosus and

rheumatoid arthritisB. K. Pelton, Margaret North, R. G. Palmer, Winsome Hylton,Caroline Smith-Burchnell, Anne L. Sinclair, M. Malkovsky,A. G. Dalgleish, and A. M. Denman 206

Complement activation and HLA-B27Seppo Meri, Jukka Partanen, Marjatta Leirisalo-Repo, andHeikki Repo 210

Association of HLA-B35 with mucocutaneous lesions in Israeli patientswith rheumatoid arthritis receiving gold treatmentM. Tishler, D. Caspi, E. Gazit, and M. Yaron 215

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The arthropathy of cystic fibrosisJosh Dixey, Andrew N. Redington, Robin C. Butler, Michael J.Smith, John R. Batchelor, David F. Woodrow, Margaret E. Hodson,John C. Batten, and Derrick A. Brewerton 218

Failure of oral thiomalate to act as an alternative to intramuscular goldin rheumatoid arthritis

S. R. Rudge, D. Perrett, and M. Kelly 224Complications of pregnancy and benign familial joint hyperlaxity

J. G. Thornton, J. Hill, and H. A. Bird 228Morphology of surface synoviocytes in situ at normal and raised joint

pressure, studied by scanning electron microscopyJ. N. McDonald and J. R. Levick 232

Inhibition of leucotriene B4 synthesis by BW 755c does not reduce poly-morphonuclear leucocyte (PMNL) accumulation induced bymonosodium urate crystalsM. J. Forrest, V. Zammit, and P. M. Brooks 241

A. monoclonal antibody raised by immunising mice with group Astreptococci binds to agalactosyl IgG from rheumatoid arthritis

G. A. W. Rook, J. Steele, and T. Rademacher 247Pulmonary hypertension in primary Sjogren's syndrome

Madelaine T. Hedgpeth and Dennis W. Boulware 251Arthritis in Down's syndrome

J. E. Dacre and E. C. Huskisson 254Rheumatoid disease presenting as a nephrotic syndrome

C. D. Short, L. R. Solomon, N. P. Mallick and J. D. Mackay 256Conference report: Theoretical medicine: the pathogenesis of osteo-

arthritis 258Correspondence 260Book reviews 263

No. 4 April, 1988Leading article: Epstein-Barr virus infection and autoimmunity in

rheumatoid arthritisPatrick Venables 265

Reaction of antibodies to rheumatoid arthritis nuclear antigen with asynthetic peptide corresponding to part of Epstein-Barr nuclearantigen 1

Patrick J. W. Venables, Tommasz Pawlowski, Pat A. Mumford,Christina Brown, Dorothy H. Crawford, and Ravinder N. Maini 270

-T. cell cytotoxicity to Epstein-Barr virus infected B cells: comparison ofpatients with rheumatoid arthritis and their HLA identical siblings

Vivienne R. Winrow, Janice Norton, E. John Holborow, Helmut EStierle, Adam Young, and John A. Sachs 280

IgG subclass and light chain distribution of anticardiolipin and anti-DNAantibodies in systemic lupus erythematosusA. E. Gharavi, E. N. Harris, M. D. Lockshin, G. R. V. Hughes, andK. B. Elkon 286

Fuctional affinity of IgM rheumatoid factor in patients with rheumatoidarthritis and other autoimmune diseases

S. Rath, D. N. Hogben, and M. E. Devey 291

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Evidence that Chlamydia trachomatis causes seronegative arthritis inwomen

D. Taylor-Robinson, B. J. Thomas, J. Dixey, M. F. Osborn,P. M. Furr, and A. C. Keat 295

The synovial membrane in osteoarthritis: a histological study includingthe characterisation of the cellular infiltrate present in inflammatoryosteoarthritis using monoclonal antibodies

Peter A. Revell, Vivien Mayston, Peggy Lalor, and Paul Mapp 300Serum cytidine deaminase levels after withdrawal of non-steroidal anti-

inflammatory treatment in rheumatoid arthritisP. W Thompson, J. R. Kirwan, D. D. Jones, and H. L. F. Currey 308

Autoantibodies to type 11 collagen: occurrence in rheumatoid arthritis,other arthritides, autoimmune connective tissue diseases, andchronic inflammatory syndromesEdward K. K. Choi, Paul A. Gatenby, Neil W. McGill, John F.Bateman, William G. Cole, and John R. York 313

Co-trimoxazole in rheumatoid arthritis: a comparison with sulphapyridineC. Astbury, J. Hill, andH. A. Bird 323

Anti-inflammatory drugs modulate histamine release from mast cellsinduced by fibrinogen degradation products

E. Wojtecka-Lukasik, J. Stachurska, M. Kopec, and S. Maslinski 328Acute vertebral osteomyelitis complicating Streptococcus sanguis

endocarditisChristine Demers, Michel Tremblay, and Yves Lacourciere 333

Sarcoidosis presenting as antinuclear antibody positive glomerulo-nephritisMaria Cristina Soto-Aguilar and Dennis W. Boulware 337

Polymyositis after propylthiouracil treatment for hyperthyroidismWilliam J. Shergy and David S. Caldwell 340

Discovertebral destruction in ankylosing spondylitis complicated byspinal cord compression

P. Jobanputra, B. Kirkham, 0. Duke, A. Crockard, and G. D. Panayi 344Viewpoint: Synovial lining cell hyperplasia in rheumatoid arthritis:

dogma and factB. Henderson, P. A. Revell and J. C. W. Edwards 348

Correspondence 350Book reviews 351Special announcements 352

No. 5 May, 1988Identification by cell electrophoresis of a subpopulation of poly-

morphonuclear cells which is increased in patients with rheumatoidarthritis and certain other rheumatological disorders

K. A. Brown, J. D. Perry, C. Black, and D. C. Dumonde 353Reduction of the surface charge of blood polymorphonuclear cells by

rheumatoid sera and heat induced aggregated human IgG (HAGG)K. A. Brown, D. McCarthy, J. D. Perry, and C. Dumonde 359

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Coagulation screen is more specific than the anticardiolipin antibodyELISA in defining a thrombotic subset of lupus patientsRonald H. W. M. Derksen, Paula Hasselaar, Laya Blokzijl, FritsH. J. Gmelig Meyling, and Philip G. De Groot 364

Demonstration of impaired T cell regulation of Epstein-Barr virusstimulated B lymphocytes in rheumatoid arthritis with HLAidentical, disease discordant sibling pairsMarie-Claude Fawcett, D. J. Walker, and 1. D. Griffiths 372

Binding of haptoglobin, inter-a-trypsin inhibitor, and a, proteinaseinhibitor to synovial fluid hyaluronate and the influence of theseproteins on its degradation by oxygen derived free radicalsNongporn Hutadilok, Peter Ghosh, and Peter M. Brooks 377

Psoriatic spondyloarthropathy: a long term prospective studyJohn G. Hanly, M. Lynn Russell, and Dafna D. Gladman 386

Adenosine deaminase activity in rheumatoid pleural effusion1. Ocana, E. Ribera, J. M. Martinez-Vazquez, 1. Ruiz, E. Bejarano,C. Pigrau, and A. Pahissa 394

Immunohistology of rheumatoid nodules and rheumatoid synoviumN. A. Athanasou, J. Quinn, C. G. Woods, and O'd McGee 398

Decreased iron absorbance in patients with active rheumatoid arthritis,with and without iron deficiency

J. Weber, J. M. Werre, H. W. Julius, and J. J. M. Marx 404Antiocardiolipin antibodies in patients with primary immunodeficiency

diseasesDora Pascual-Salcedo, Maria Cruz Garcia Rodriguez, MargaritaLopez Trascasa, and Gumersindo Fontan 410

Differential response to compressive loads of zones of canine hyalinearticular cartilage, micromechanical, light and electron microscopicstudies

Patricia O'Connor, Constance R. Orford, and Dugald L. Gardner 414Contact allergy to gold after systemic administration of gold for rheuma-

toid arthritis1. P. Wicks, D. Wong, R. B. McCullagh, and A. Fleming 421

Subacute bacterial endocarditis in a patient with ankylosing spondylitisRichardA. Hoppmann, Christopher M. Wise, Venkata R. Challa, andJames E. Peacock 423

Acute confusional state and hyponatraemia due to inappropriate anti-diuretic hormone secretion in polyarteritis nodosa

J. S. H. Gaston, D. G. /. Scott, and P. A. Bacon 428Viewpoint: B27 positive diseases versus B27 negative diseases

A. Linssen, and T. E. W.Feltkamp 431Correspondence 440Notes 440

No. 6 June, 1988Increased incidence of spontaneous abortion and infertility in women

with scleroderma before disease onset: a controlled studyAlan J. Silman and Carol Black 441

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Increased sensitivity of lymphocytes from patients with systemicautoimmune diseases to DNA alkylation by the methylatingcarcinogen N-methyl-N-nitrosourea

P. D. Lawley, R. Topper, A. M. Denman, W. Hylton, L. D. Hill, andG. Harris 445

Polymorphonuclear leucocyte function and previous yersinia arthritis:correlation of enhanced superoxide production with late mani-

festationsHeikki Repo, Paivi Koivuranta-Varra, and Marjatta Leirisalo-Repo 452

Evaluation of disease activity in rheumatic patients by leucocyteadhesiveness/aggregationShlomo Berliner, Moshe Fried, Dan Caspi, Abraham Weinberger,Michael Yaron, Jack Pinkhas, and Moshe Aronson 458

P component in the synovium in rheumatoid and osteoarthritisM. G. Butler, A. J. D'Ardenne, and D. L. Scott 463

Urinary proteoglycan degradation product excretion in patients withrheumatoid arthritis and osteoarthritis

J. Krajickova and J. Macek 468Changes of lymphocyte membrane fluidity in rheumatoid arthritis: a

fluorescence polarisation studyE. Beccerica, G. Piergiacomi, G. Curatola, and G. Ferretti 472

Peptic ulcer in rheumatoid arthritisD. Farah, R. D. Sturrock, and R. L. Russell 478

Alterations in appendicular skeletal mass in patients with rheumatoid,psoriatic, and osteoarthropathy

C. Cooper, V. Poll, M. McLaren, S. O'n Daunt, and M. . D. Cawley 481Inflammatory joint disease: a comparison of liposome scanning, bone

scanning, and radiographyM. M. O'Sullivan, N. Powell, A. P. French, K. E. Williams,J. R. Morgan, and B. D. Williams 485

Serum and synovial fluid adenosine deaminase activity in patients withrheumatoid arthritis, osteoarthritis, and reactive arthritis

H. Yuksel and T. F. Akoglu 492A double blind, placebo controlled trial of intravenous methylpred-

nisolone in systemic lupus erythematosusC. G. Mackworth-Young, J. David, S. H. Morgan, and G. R. V. Hughes 496

Pancytopenia related to azathioprine in rheumatoid arthritisM. E. C. Jeurissen, A. M. Th Boerbooms, and L. B. A. Van de Putte 503

Sodium aurothiomalate does not block interleukin 1 production inrabbitsYehuda Zurovsky, Helen P. Laburn, Duncan Mitchell, and AngelaRuck 506

Effect of two gold compounds on lysosomesPernille M0ller Graabaek and Susanne M0ller Pedersen 509

Effect of auranofin on plasma fibronectin, C reactive protein, and albuminlevels in arthritic ratsKevin M. Connolly, Vera J. Stecher, and Donald J. Pruden 515

Intervertebral infection due to Candida albicans in an intravenous heroinabuser

L. F. Rowe, E. D. Wright, C. S. Higgens, and J. P. Burnie 522Correspondence 526Book reviews 527Note 528

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No. 7 July, 1988Leading article: Immunisation of patients with rheumatoid arthritis and

systemic lupus erythematosusLynne Turner-Stokes and David A. Isenberg 529

In vitro response to influenza immunisation by peripheral bloodmononuclear cells from patients with systemic lupus erythematosusand other autoimmune diseases

L. Turner-Stokes, G. Cambridge, T. Corcoran, J. S. Oxford, andM. L. Snaith 532

An IgG subclass imbalance in connective tissue diseaseR. A. Kay, K. J. Wood, R. M. Bernstein, P. J. L. Holt, andR. S. H. Pumphrey 536

Autonomic neuropathy in systemic sclerosisP. S. Klimiuk, Lesley Taylor, R. D. Baker, and M. I. V. Jayson 542

Class-specific rheumatoid factors, DR antigens, and amyloidosis inpatients with rheumatoid arthritis

C. P. J. Maury, A.-M. Teppo, F. Wafin, 0. Wegelius, C. Friman, andS. Koskimies 546

Use of single photon emission computed tomography (SPECT) to studythe distribution of 90Y in patients with Baker's cysts and persistentsynovitis of the knee

T. Smith, D. J. Shawe, J. C. W. Crawley, and J. M. Gumpel 553Comparison of serial synovial fluid cytology in rheumatoid arthritis:

delineation of subgroups with prognostic implicationsM. J. Davis, J. Denton, A. J. Freemont, and P. J. L. Holt 559

Australian mortality statistics for rheumatoid arthritis 1950-81: analysisof death certificate data

I. P. Wicks, J. Moore, and A. Fleming 563Phytohaemagglutinin induced proliferation of lymphocytes from

patients with rheumatoid arthritis and iron deficiencyRex J. Polson, Adrian Bomford, Hedley Berry, and Roger Williams 570

Raised serum albumin in hip osteoarthrosis: a comparative study inwomen of some blood chemical parameters in aging and in casesof femoral neck fractures, osteoporotic vertebral crush fractures,and hip osteoarthrosis

Charles-Henri Rapin, and Rene Lagier 576A. double blind multicentre study of OM-8980 and auranofin in

rheumatoid arthritisT. L. Vischer 582

Expression of CD 21, CD 22, and the mouse erythrocyte receptor onperipheral B. lymphocytes in rheumatoid arthritisSabine Hildebrandt, Iris Von Der Heydt, and Peter Von Wichert 588

Seronegative spondarthritis associated with Takayasu's arteritisM. Magar0, L. Altomonte, L. Mirone, A. Zoli, and G. Corvino 595

Bacterial endocarditis presenting as acute monarthritisA. Doube and A. Calin 598

Sensorineural hearing loss in adult onset Still's diseaseHarry M. Markusse, Berend Stolk, Andel G. L. Van Der Mey,Johanna M. De Jonge-Bok, and Karel J. Heering 600

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Response of rheumatoid arthritis to chemotherapy for Hodgkin'sdisease in a patient with IgA deficiency and overlap connectivetissue disease

Michael G. Cohen, Beatrice Janssen, and John Webb 603Extensive cerebral infarction due to involvement of both anterior

cerebral arteries by Wegener's granulomatosisJ. Satoh, N. Miyasaka, T. Yamada, T. Nishido, M. Okuda,T. Kuroiwa, and R. Shimokawa 606

Conference report: Third International Antiphospholipid Conference:barbecues, rum punches, and kaps

E. Nigel Harris and Graham R. V. Hughes 612Correspondence 615Book review 616Notes 616

No. 8 August, 1988Editorial: Is the gut intrinsically abnormal in rheumatoid arthritis? 617Effects of prostaglandin E2 on disease activity, gastric secretion and

intestinal permeability, and morphology in patients with rheu-matoid arthritis

A. E. K. Henriksson, C. Tagesson, A. Uribe, K. Uvnas-Moberg,C.-E. Nord, R. Gullberg, and C. Johansson 620

Participation of antigens related to the psoriasis associated antigen, psop27, in immune complex formation in patients with ankylosingspondylitisEyvind R0dahl, Kjetil Abakk, and Ole-Jan Iversen 628

Development of connective tissue disease in patients presenting withRaynaud's phenomenon: a six year follow up with emphasis on thepredictive value of antinuclear antibodies as detected by immuno-blottingCees G. M. Kallenberg, Aaktje A. Wouda, Margot H. Hoet, andWalther J. Van Venrooij 634

Induction of antinuclear antibodies in patients with rheumatoid arthritisreceiving treatment with human recombinant interferon gammaM. Seitz, M. Franke, and H. Kirchner 642

Relation of microscopic haematuria in ankylosing spondylitis to circu-lating IgA containing immune complexesAndr6 J. Peeters, A. Warmold L. Van Den Wall Bake, Annette D.Van Dalsen, and Marie-Louise Westedt 645

Prediction of erosiveness and rate of development of new erosions inearly rheumatoid arthritis

T. T. Mottonen 648Methotrexate in rheumatoid arthritis: a prospective study in Israeli

patients with immunogenetic correlationsMoshe Tishler, Dan Caspi, Tal 0. Rosenbach, Beno Fishel,Irena Wigler, Rafael Segal, Ephraim Gazit, and Michael Yaron 654

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Spinal trabecular bone mineral content in patients with non-steroidtreated rheumatoid arthritis

J. E. Compston, E. 0. Crawley, C. Evans, and M. M. O'Sullivan 660Serum a, antichymotrypsin concentration as a marker of disease activity

in rheumatoid arthritisM. D. Chard, J. Calvin, C. P. Price, T. E. Cawston, and B. L. Hazleman 665

Normal cardiovascular autonomic function in patients with systemicsclerosis (CREST variant)Maria E. Suarez-Almazor, Eduardo Bruera, andAnthony S. Russell 672

Complement mediated inhibition of immune precipitation in rheumatiodarthritis: studies on interaction of heat aggregated IgG with IgMrheumatoid factorM. M. O'Sullivan, N. Amos, and B. D. Williams 675

Chorea in systemic lupus erythematosus: association with antiphospho-lipid antibodiesM. A. Khamashta, A. Gil, B. Anciones, P. Lavilla, M. E. Valencia,V. Pintado, and J. J. Vazquez 681

Cathepsin B. as a marker of the dedifferentiated chondrocyte phenotypeAntonio Baici, Angela Lang, Dorothy Horler, and Margrit Knopfel 684

Osteomalacia and coeliac disease presenting as isolated dactylitisA. S. M. Jawad, S. B. Squire, and J. D. Perry 692

Osteomyelitis presenting as a swollen elbow in a patient with theacquired immune deficiency syndrome

B. T. Goh, A. S. M. Jawad, D. Chapman, S. J. Winceslaus,G. E. Forster, and J. D. Perry 695

Viewpoint: Rheumatoid arthritis and gut related lymphocytes: theiteropathy concept

P. Sheldon 697Correspondence 701Note 704

No. 9 September, 1988Leading article: Idiotypes and anti-idiotypes: What are they trying to

tell us?Relation of antivimentin antibodies to anticardiolipin antibodies in

systemic lupus erythematosusMartin A. Blaschek, Michael Boehme, Jean Jouquan, Anne-MarieSimitzis, Spyros Fifas, Paul Le Goff, and Pierre Youinou 708

Disease activity in systemic lupus erythematosus related to a range ofantibodies binding DNA. and synthetic polynucleotidesDavid A. Isenberg, Carol Dudeney, Warren Williams, AndrewTodd-Pokropek, and B. David Stollar 717

Lymphocytotoxic antibodies in systemic lupus erythematosus: studiesof their temperature dependence, binding characteristics, andspecificity in vitro

P. W Peake, J. D. Greenstein, V. Timmermans, L. Gavrilovic, andJ. A. Charlesworth 725

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Polymyalgia rheumatica and temporal arteritis: a retrospective analysisof prognostic features and different corticosteroid regimens(11 year survey of 210 patients)

D. Delecoeuillerie, P. Joly, A. Cohen De Lara, and J. B. Paolaggi 733The first international standard for antibodies to double stranded DNA

T. E. W. Feltkamp, T. B. L. Kirkwood, R. N. Maini, and L. A. Aarden 740Ultrastructural localisation of alkaline phosphatase activity in osteo-

arthritic human articular cartilageJ. A. Rees and S. Y. Ali 747

Lack of objective evidence of stiffness in rheumatoid arthritisP. S. Helliwell, A. Howe, and V. Wright 754

Screening for proteinuria in a rheumatology clinic: comparison ofdipstick testing, 24 hour urine quantitative protein, and protein/creatinine ratio in random urine samples

Stuart H. Ralston, Nell Caine, lain Richards, Denis O'Reilly,Roger D. Sturrock, and Hilary A. Capell 759

Adult onset Still's disease and viral infectionsJacques M. G. W. Wouters, Johan Van Der Veen, Levinus B. A.Van de Putte, and Dirk-Jan R. A. M. de Rooij 764

Tumour necrosis factor in synovial exudatesFrancesco S. Di Giovine, George Nuki, and Gordon W. Duff 768

Clinical assessment of disease activity in rheumatoid arthritis:evaluation of a functional test

A. A. Kalla, T. J. v W. Kotze, 0. L. Meyers, and N. D. Parkyn 773Ankylosing spondylitis with predominant involvement of the cervical

spine in a woman with Behqet's syndromeIgnazio Olivieri, Gabriele Gemignani, Francesco Busoni, FaustoPecori, Emilio Camerini, Donatella Trippi, and Giampiero Pasero 780

Life threatening acute pneumonitis during low dose methotrexatetreatment for rheumatoid arthritis: a case report and review of theliteratureM. G. Ridley, C. S. Wolfe, and J. A. Mathews 784

Correspondence 789Book reviews 792Note 792

No. 10 October, 1988Influence of diet with different lipid composition on neutrophil chemi-

luminescence and disease activity in patients with rheumatoidarthritisM. Magaro', L. Altomonte, A. Zoli, L. Mirone, P. De Sole,G. Di Mario, S. Lippa, and A. Oradei 793

Chondronectin in human synovial fluidSteven Carsons and Valerie J. Horn 797

Activation of neutral metalloprotease in human osteoarthritic kneecartilage: evidence for degradation in the core protein of sulphatedproteoglycanJohanne Martel-Pelletier, Jean-Pierre Pelletier, and Charles J.Malemud 801

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Palmoplantar pustulosis and sternocostoclavicular arthro-osteitisEva Edlund, Ulf Johnsson, Lars Lidgren, Holger Pettersson,Gunnar Sturfelt, Bjorn Svensson, Jan Theander, and HelenaWillen 809

Predictive clinical and laboratory parameters for serum zinc and copperin rheumatoid arthritisHelena Mussalo-Rauhamaa, Yrjo T. Konttinen, Jari Lehto, andVisa Honkanen 816

Specificity of anti-Sm antibodies by ELISA for systemic lupus ery-thematosus: increased sensitivity of detection using purifiedpeptide antigensM. Field, D. G. Williams, P. Charles, and R. N. Maini 820

Increased concentrations of proteoglycan components in the synovialfluids of patients with acute but not chronic joint disease

A. Ratcliffe, M. Doherty, R. N. Maini, and T. E. Hardingham 826Circulating levels of sialic acid and glycosaminoglycans: a diagnostic

test for ankylosing spondylitisA. K. Susheela, Taposh K. Das, Jasvir S. Khurana, A. Jayaswal,and P. K. Dave 833

Perivascular infiltration in normal skin of patients with rheumatoidarthritis: association with rheumatoid factors and HLA-DR antigens

H. J. Bernelot Moens, H. J. W. Ament, Th M Vroom, T. E. W.Feltkamp, and J. K. Van der Korst 838

Chromosome 14 markers in rheumatoid arthritisW. Ollier, W. Thomson, S. Welch, G. G. de Lange, and A. Silman 843

Immune mediated mechanism for thrombosis: antiphospholipid anti-body binding to platelet membranesMunther A. Khamashta, E. Nigel Harris, Azzudin E. Gharavi,Genevieve Derue, Antonio Gil, Juan Jose Vazquez, and GrahamR. V. Hughes 849

Effects of murine recombinant interleukin 1 on intact homologousarticular cartilage: a quantitative and autoradiographic studyWim B. Van Den Berg, Fons A. J. Van de Loo, Wil A. Zwarts, andIvan G. Otterness 855

Triple crystal disease: monosodium urate monohydrate, calcium pyro-phosphate dihydrate, and basic calcium phosphate in a single jointPaul B. Halverson and Lawrence M. Ryan 864

Infection of a prosthetic knee joint with Peptostreptococcus magnusUrsula M. Davies, Alison M. Leak, and Jayshree Dave 866

Pulmonary haemorrhage, pulmonary infarction, and the lupus anti-coagulant

H. S. Howe, M. L. Boey, K. Y. Fong, and P. H. Feng 869Large granular lymphocytosis associated with rheumatoid arthritis

A. Samanta, I. Grant, F. E. Nichol, J. H. Pringle, J. K. Wood, andA. C. Campbell 873

Conference report: Advances in the assessment of arthritisH. A. Bird 876

Correspondence 878Note 880

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No. 11 November, 1988Review: Neovascularisation and its role in the osteoarthritic process

Robert A. Brown and Jacqueline B. Weiss 881Humoral immunity to link protein in patients with inflammatory joint

disease, osteoarthritis, and in non-arthritic controlsA. K. Austin, R. N. Hobbs, J. C. Anderson, R. C. Butler, andB. A. Ashton 886

Immunoglobulin allotype Gm(1 ,2;21) in ankylosing spondylitis withperipheral arthritis

R. Mierau, C. A. von Muhlen, H. Zarnowski, E. Genth, andP. W Hartl 893

Reaction of rheumatoid factors with IgG3 monoclonal anti-Rh(D) anti-bodies: more frequent reactivity to a monoclonal antibody of theGm allotype G3m(5) in rheumatoid patients negative for G3m(5)Alison H. Puttick, Elizabeth A. Williamson, A. H. Merry, Belinda M.Kumpel, K. M. Thompson, and Valerie E. Jones 898

Standardisation of the quantitative determination of antinuclear anti-bodies (ANAs) with a homogeneous pattern

T. E. W. Feltkamp, F. Klein, and M. B. J. A. Janssens 906Physiology of the retrocalcaneal bursa

Juan J. Canoso, Nancy Liu, Mark R. Traill, and Val M. Runge 910Correlation of the activation of the fourth component of complement

(C4) with disease activity in systemic lupus erythematosusG. Senaldi, V. A. Makinde, D. Vergani, and D. A. Isenberg 913

Clinical and autoantibody correlations in Orientals with systemic lupuserythematosusM. L. Boey, C. L. Peebles, G. Tsay, P. H. Feng, and E. M. Tan 918

Combined suppressive drug treatment in severe refractory rheumatoiddisease: an analysis of the relative effects of parenteral methyl-prednisolone, cyclophosphamide, and sodium aurothiomalateM. T. Walters, and M. I. D. Cawley 924

Survey of the long term incidence of osteonecrosis of the hip andadverse medical events in rheumatoid arthritis after high doseintravenous methylprednisolone

I. A. Williams, A. D. Mitchell, W. Rothman, P. Tallett, K. Williams,and P. Pitt 930

An evaluation of the dynamic qualities of isometric grip strengthP. S. Helliwell, A. Howe, and V. Wright 934

Experimental arthritis in C57blackI6 normal and beige (Chediak-Higashi)mice: in vivo and in vitro observations on cartilage degradationJoost Schalkwijk, Leo A. B. Joosten, Wim B. van den Berg, andLevinus B. A. van de Putte 940

Diagnostic and therapeutic problems in two patients with antiphospho-lipid antibodies, heart valve lesions, and transient ischaemic attacks

R. A. Asherson, D. G. Gibson, D. W. Evans, E. Baguley, and G. R. V.Hughes 947

Cerebellar ataxia in systemic lupus erythematosus: three case reportsR. R. Singh, K. Prasad, AshokKumar, Anoop Misra, K. Padmakumar,and A. N. Malaviya 954

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lschaemic necrosis of the ilium complicating haemolytic anaemia dueto an unstable haemoglobin

N. W. McGill, P. Warburton, H. Kronenberg, J. E. Hassall, andM. A. Rossleigh 957

Constrictive pericarditis complicating dermatomyositisRami Tamir, A. J. Pick, and Emanuel Theodor 961

Correspondence 964Book reviews 967Notes 968

No. 12 December, 1988Review: Psychological factors in patients with chronic rheumatoid

arthritisBahv Oberai and John R. Kirwan 969

Mechanism of anaemia in rheumatoid arthritis: demonstration of raisedinterleukin 1D concentrations in anaemic patients and of inter-leukin 1 mediated suppression of normal erythropoiesis andproliferation of human erythroleukaemia (HEL) cells in vitro

C. P. J. Maury, L. C. Andersson, A-M. Teppo, S. Partanen, andE. Juvonen 972

Adverse reproductive outcomes in women who subsequently developrheumatoid arthritisAlan J. Silman, Eve Roman, Valerie Beral, and Ann Brown 979

Outcome of pregnancy in patients with autoimmune rheumatic diseasebefore the disease onsetA. Siamopoulou-Mavridou, M. N. Manoussakis, A. K. Mavridis,and H. M. Moutsopoulos 982

Lymphoproliferative cancer and other malignancy in patients withrheumatoid arthritis treated with azathioprine: a 20 year follow upstudyAlan J. Silman, John Petrie, Brian Hazleman, and Stephen J. W.Evans 988

Haematuria in rheumatoid arthritis: a follow up studyC. A. Kelly, P. Mooney, L. D. Hordon, and I. D. Griffiths 993

Scintimetric assessment of synovitis activity during treatment withdisease modifying antirheumatic drugs

Niels Olsen, Poul Halberg, Ole Halskov, and Michael W. Bentzon 995Ankylosing spondylitis without B27: no evidence for gene conversion

C. T. Pease, S. A. Ellis, A. J. McMichael, and D. A. Brewerton 1001Immunoglobin A. in the skin of patients with ankylosing spondylitis

Antonio Collado, Raimon Sanmarti, Isabel Bielsa, Teresa Castel,Eduardo Kanterewicz, Juan D. Canete, Maria A. Branc6s, andJaime Rotes-Querol 1004

Antibodies to type 11 and XI collagens: evidence for the formation ofantigen specific as well as cross reacting antibodies in patients withrheumatoid arthritis

Keith Morgan, Catherine Buckee, Ian Collins, Shirley Ayad,Roy B. Clague, and P. J. Lennox Holt 1008

Effect of intermittent stretch on immobilised musclePamela E. Williams 1014

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Atrioventricular conduction disturbance as an early feature of- Reiter'ssyndrome

J. F. Haverman, G. A. Van Albada-Kuipers, H. J. M. Dohmen, andB. A. C. Dijkmans 1017

Relapsing polychondritis mimicking rheumatoid arthritisP. Schlapbach, N. J. Gerber, P. Ramser, and F. M. Van't Hooft 1021

Intra-articular apatite deposition in mixed connective tissue disease:crystallographic and technetium scanning characteristics

C. W. Hutton, P. J. Maddison, A. J. Collins, and J. A. Berriman 1027Steroid resistant pleural effusion in systemic lupus erythematosus

treated with tetracycline pleurodesisM. H. Gilleece, C. C. Evans, and R. C. Bucknall 1031

Notes 1033Index 1035

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Documents

Annalsof the Rheumatic Diseases January 1988