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Animal Health A Durable Industry

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Page 1: Animal Health A Durable Industry
Page 2: Animal Health A Durable Industry
Page 3: Animal Health A Durable Industry
Page 4: Animal Health A Durable Industry
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Page 13: Animal Health A Durable Industry
Page 14: Animal Health A Durable Industry

2015 Analyst Day December 8, 2015

Page 15: Animal Health A Durable Industry

Elanco Overview

©2015 Elanco

Jeff Simmons President, Elanco Animal Health

2

Page 16: Animal Health A Durable Industry

Key Messages

©2015 Elanco

What Should Investors Expect of Elanco

Growth and improving profitability

Proven Track Record, Proven Strategy

How Elanco has become a top 3 player in attractive

animal health industry

Future Sustainable Outperformance

Driven by the right model and key differentiators

3

Page 17: Animal Health A Durable Industry

Headlines

©2015 Elanco

Revenue: We are positioned to outperform long term

Novartis: Acquisition significantly exceeding expectations;

50% greater savings

Margins: Progressing on a path to 30% margins(1)

1

Innovation: Rich pipeline with 7 recent or upcoming

launches

Lilly: One of three core Lilly businesses; Building on an

already strong model

2

3

4

5

4 (1) Operating margins excluding amortization of intangibles

Page 18: Animal Health A Durable Industry

Food Animal Realities: The Case For Animal Health

©2015 Elanco

PROTEIN DEMAND

60% increase in

demand

Middle class

Changing diets

ANIMAL WELFARE

Dynamic animal health

environment, increasing

disease challenges

ONE HEALTH

1 in 2 getting

wrong nutrition,

Healthy food =

Healthy people OPPORTUNITY

Productivity

Innovation

Leadership

Shaping

ENVIRONMENT

Increasingly overusing

environmental resources

Productivity vs Animals

5

Page 19: Animal Health A Durable Industry

@Elanco

TM

#FeedThe9

Facebook.com/

ENOUGHmovement @ENOUGH2050 @ENOUGH2050

11,000

Global

Advocates

1 Million

Impressions

Per Week

Elanco’s Enough Movement

www.enoughmovement.com

6

Page 20: Animal Health A Durable Industry

Companion Animal Realities: Growing Role of the Pet

©2015 Elanco

DOMESTICATION

Pets increasing in

homes, beds

MIDDLE CLASS

More disposable income

EXPANDING

MARKET

Increased spending

OPPORTUNITY Need for veterinary care

Innovation

Ease of use

POPULATION

DYNAMICS

Aging singles

or fewer children

AGING PETS

Pets living longer

lives face age-

related diseases

7

Page 21: Animal Health A Durable Industry

REST OF WORLD

23%

EUROPE

31%

AMERICAS

46%

Demand Trends Result in Attractive Industry Growth $24B Global Market in 2014, Growing 4-5%

AH Spending By Region Industry Growing 4-5% Over Next 10 Years

Source: Vetnosis

Growth in

Animal

Numbers

Pricing

4-5%

Industry

Growth

New Innovation

and PLEs

Page 22: Animal Health A Durable Industry

©2015 Elanco

Therapeutic Area

Source: Vetnosis 2014 data

Species

Ruminants

Pigs

Poultry

Companion

Animal

41%

OPs

Bios

26%

Als

OPs – Other pharmaceuticals

MFAs – Medicated feed additives

BIOs – Vaccines

Paras – Parasiticide

AIs – Anti-infectives

Food

Animal

59%

Paras MFAs

12%

Pharmas

62%

Region

North

America

West

Europe

Eastern

Europe

Far East

Rest of

World

Latin

America

Europe

31%

Americas

46%

Others

23%

Animal Health Industry Components of $24B Global Market

9

Page 23: Animal Health A Durable Industry

Animal Health A Durable Industry

©2015 Elanco

Industry Elanco

Average age of product portfolio is

18 yrs, due to continuous product

improvement and line extensions

Long-lived assets and diversity

of species

23% of portfolio under patent

protection; Elanco revenue of off-

patent products continues to grow

Attractive growth despite low

patent protection

Innovation is rewarded Over 1/3 of Elanco’s growth

(2007-2014) from new innovation

10

Page 24: Animal Health A Durable Industry

OUR VISION: Food and companionship enriching life

FOOD COMPANIONSHIP

6,700 employees

2,304 commercial

force

300+ brands

4,800 SKUs

Top 10 products

are 50% of revenue

Operates

in

countries

70 10.2

years average tenure

High

employee engagement

16% of Lilly

revenue

13% market share

Elanco Overview

Since

1954

Page 25: Animal Health A Durable Industry

Counter-cyclical

transformation

Transition to

core growth

Sustainable

growth driver

$1B to $2.3B

13% CAGR

60% Organic

OMs 17% to 26%(1)

(1) Operating margins excluding amortization of intangible assets.

GO

AL

S Deliver integration

Deliver 7 new products

Expand margins(1)

Outgrow industry

Expand margins(1)

2017 - 2020 2015 - 2016 2007 - 2014

©2015 Elanco

5% of Lilly’s revenue at

beginning of period YTD 16% of Lilly’s

revenue

Lilly’s Strategic Intent in Animal Health Components of $24B Global Market

12

Page 26: Animal Health A Durable Industry

Our Commitments: Delivery

©2015 Elanco

What We Said What We Did

Diversify and increase value

proposition

• 5 new businesses

• 9 strategic acquisitions

Provide YZ growth to Lilly Grew revenue 70% from 2010 to 2014

Double profit from 2010 to 2013 Achieved in two years

13

Page 27: Animal Health A Durable Industry

©2015 Elanco

Elanco 13% Revenue CAGR AH Industry 4% Growth CAGR

(8 ppts organic)

(1)

(1) Source: Vetnosis

-5%

0%

5%

10%

15%

20%

25%

2007 2008 2009 2010 2011 2012 2013 2014

14%

10% 10%

15%

21% 21%

6%

9% Elanco

Industry

Gro

wth

Ra

te B

y Y

ea

r

Elanco Track Record of Outgrowing Industry 2007-2014 Period

#8 Top

3

14

Page 28: Animal Health A Durable Industry

15

Lower 2nd Tier AH Company Top Tier

AH

Company

2nd Tier AH Company

Analytics

Dairy Europe

Vaccines

Analytics

Enzymes Vaccines

Vaccines

Aquaculture,

Broaden Global

Presence

Successful M&A History Since 2007 Targeted For Animal Health Capabilities

©2015 Elanco 15

Page 29: Animal Health A Durable Industry

Beyond Product Value Differentiators

Share. Price. Brand Strength.

ANALYTICS TECHNICAL

SERVICE

STRATEGIC

ACCOUNTS

ELANCO

PULSE

INSTITUTE

MARKET

ACCESS

TRACK &

TRACE

Page 30: Animal Health A Durable Industry

Elanco Evolution More Diverse, More Capable

2006

FA

100%

Other

22%

MFA

78%

Current

Cattle

Swine

Poultry

Companion Animal (CA)

Other

3%

32% 32%

16% 17%

MFA

38%

22%

27%

5% 8%

Medicated feed additives

Vaccines

Anti-infectives

Parasiticide

Other

Dedicated

Capabilities

• Manufacturing

Footprint

• M&A

• Integration

• Elanco Knowledge

Solutions and Food

Chain Services

Revenue Mix

Food Animal 68% 17 ©2015 Elanco

Page 31: Animal Health A Durable Industry

Lilly Capabilities Fit Elanco’s Strategy

• Discovery and screening

• Pipeline / Substrate

• Development, Technical Expertise

• 1/3 of combined Elanco revenue and

pipeline came from Lilly molecules

• 10 active R&D projects in

collaboration with Lilly

• 9 projects under assessment

• Elanco capabilities support human

product development

Demand

Creation

Customers

R&D

Other • Shared services

• Functional talent / expertise

• 300 Internal transfers since 2011

AH

Research

Analytics

& Data

Market

Access

Technical

Consultants

Lilly Core Capabilities

Support Elanco...

Which Are Then Combined

With Elanco Capabilities...

To Deliver Value

To Customers

Page 32: Animal Health A Durable Industry

Why Lilly Ownership Model has Been Successful for Elanco

©2015 Elanco

Benefit of Lilly Capabilities

and Support… …With Autonomy

Dedicated Commercial Footprint

Separate Manufacturing Footprint

Independent Board of Advisors

Streamlined Governance

Separate Headquarters

Separate Compensation Structure

19

Page 33: Animal Health A Durable Industry

©2015 Elanco

Today’s Presenters

20

Page 34: Animal Health A Durable Industry

Demand Creation

©2015 Elanco

Eric Graves Vice President, Integration

21

Page 35: Animal Health A Durable Industry

Demand Creation Go to Market Model, Growth Engines

©2015 Elanco

Top 3 Animal Health

Company

Constantly

Optimizing Go To Market Model

Focused Growth

Engines

Page 36: Animal Health A Durable Industry

$-

$0.5

$1.0

$1.5

$2.0

$2.5

$3.0

$3.5

2006 2007 2008 2009 2010 2011 2012 2013 2014 Trailing12 mo.

Track Record of Revenue Growth “Big Movers”

• History of

growth –

every year

• Organic (60%)

plus inorganic

from 2007-

2014

• Innovation

and acquired

product

success

Revenue (in $Bil)

Parasiticide

Competition

Page 37: Animal Health A Durable Industry

Commercial Capabilities

Brands and Portfolio

Advanced

strategic

account

management

capabilities

Demand Creation:

Large salesforce and

technical consultants plus

distributor partnerships

Analytics Market Access

Product value

• Supply chain

• Quality

24

Page 38: Animal Health A Durable Industry

Brands and Portfolio Strength

Swine >$500M Poultry >$500M

• Broadest Parasiticide Portfolio

• Growing Therapeutic Portfolio

• Feedlot + Cow/Calf + Stocker

• Dairy Strength + Innovation

• Nursery + Finisher Expertise

• Product Innovation + Industry-

Leading Analytical Tools

Cattle

Swine

Poultry

Companion

Animal (CA)

Other

3%

32% 32%

16% 17%

• Intestinal Integrity #1

• Salmonella Vaccine #1

• Enzyme / Nutritional Health Growth+++

Companion Animal >$1B Cattle >$1B

• Vaccines

Page 39: Animal Health A Durable Industry

Constantly Optimizing Go-To-Market Model

©2015 Elanco

Shared

Demand

Creation

Logistics Partner

Direct

Depending on Segment, Customer, or Product,

Elanco utilizes several paths to the customer

DIRECT

Elanco creates demand and

handles logistics

LOGISTICS PARTNER

Elanco creates

demand, strategic partner

handles logistics

SHARED DEMAND

CREATION

Elanco and strategic

distribution partner

complementing strengths

• Result: Highly efficient model

• $2M revenue per sales rep

Page 40: Animal Health A Durable Industry

Vaccines Non-Parasiticides Geo Expansion

Growth Engines Above Industry Growth Expected

Base Business Growth

Companion

Animal

Therapeutics

Transforming

Food Animal

Emerging

Geographies

Strategic

Accounts

(1) Although overlap exists between growth engine segments, in total they represent >50% of revenue

Page 41: Animal Health A Durable Industry

Growth Engines Companion Animal Therapeutics

Companion Animal Therapeutics

“Veterinary Relevance”

• <1% of total revenue in 2009; >10% in 2016(1)

• Significantly broader portfolio with Novartis

• Supportive macro trends

Pain

Management Otitis Externa Cardiology

Dermatology Surgical

28 (1) Remainder of companion animal portfolio consists of parasiticide products

Page 42: Animal Health A Durable Industry

“New Spaces, Opportunities”

Nutritional Health

Enzymes:

Poultry, swine

Antibiotic alternatives

Supports “clean

label” trend

Immune

Restoration

Dairy

Transforming Food Animal

Vaccines

Cattle (cow-calf)

Swine (respiratory)

Poultry (salmonella)

Aquaculture

Combined <2% of revenue in 2009; 10-15% of revenue in 2016

Growth Engines Transforming Food Animal

29

Page 43: Animal Health A Durable Industry

Growth Engines Emerging Geographies

“Significantly Increased Footprint, Capabilities, Portfolio”

Russia / Africa:

Emerging Geographies

Asia Pacific, Latin America, Eastern

Europe and Africa

(combined approximately 30% of revenue in 2016)

Asia Pacific:

From third tier to top tier

<40 customer facing roles

in China to 200+

Doubled footprint in

Thailand and Vietnam

Doubled footprint in

Africa

Doubled companion

animal team in Russia

Latin America:

Doubled Brazil

companion animal team

50% increase in Mexico

footprint

Doubled Andean region

30

Page 44: Animal Health A Durable Industry

Demand Creation Summary

©2015 Elanco

1 2 3

Brand and

Portfolio Leverage

+ Capabilities for

Complex Go-to-

Market Models

Focused on

Growth

Engines

History of

Growth of

Both Acquired

and Organic

Products

31

Page 45: Animal Health A Durable Industry

Demand Creation Value Beyond Product

©2015 Elanco

Tony Ezell Vice President, Marketing

32

Page 46: Animal Health A Durable Industry

Value Beyond Product Strategic Accounts, Analytics, Market Access

©2015 Elanco

Analytics

“Voice of

the Animal”

Market Access

“Voice of the

Consumer”

Strategic Account

Management

Capabilities

Page 47: Animal Health A Durable Industry

©2015 Elanco

Strategic Accounts(1) 1

Strategic Account Management Process:

2 Portfolio

Analytics

Market Access

Process Efficiency

Training & Development

Revenue

Growth Margins

Expedite

Adoption of

Innovation 3

(1) Approximately 20% of revenue in 2016

Strategic Account Management

34

Page 48: Animal Health A Durable Industry

Industry leading

knowledge

solutions

services &

offerings

Data Analysis &

Optimization

Data Visualization

Disease Prevalence

Process Efficiency Benchmarking

Consulting

Customer Support

In the US, increased

sales per head on

average when

analytics services

are included in

portfolio sale(1) (1) Beef analytics services have been available the longest

while swine analytics are a more recent offering

Beef 55-85%

Poultry 40-50%

Swine 10-20%

Analytics Elanco Knowledge Solutions - A Competitive Advantage

35

Page 49: Animal Health A Durable Industry

Beef – Margin Insight Improving Feedyard Profitability

What it is: A data-driven margin-tracking

tool for feedyard managers

• Predicts estimated real-time margins &

manages exposure to market risk

Value:

• Allows you to analyze cattle

performance, feed consumption &

market prices (cash & futures)

• Comprehensive view of forward-

looking feedyard profit margins

• Provides feedyards a snapshot of

their unmet corn needs and a

window into future cattle needs

Improving profitability in your risk management decision-making

36 ©2015 Elanco

Page 50: Animal Health A Durable Industry

Dairy – Economic Assessment Tool Managing Disease Cost

Understand and improve

transition cow economics

What it is: Assessment to identify, understand and

manage disease cost and incidence throughout The

Vital 90™ Days

Value: By demonstrating economic

outcomes when disease incidence is

reduced, producers are able to

evaluate management

interventions before making

changes that impact profitability

Quote from customer: “Even if I paid $500 for this

assessment, that’s only $1 per cow calving in a year’s time. And,

I saved way more than that in reduced losses as a

result of the changes we made.”

--Ohio producer

37 ©2015 Elanco

Page 51: Animal Health A Durable Industry

Poultry – Health Tracking System Extensive Poultry Health Database

What it is: An extensive database

containing poultry health data from more

than 1,000 production locations across 50

countries established in 1993

Value:

• Helps producers understand and

respond to enteric, respiratory,

immunological and skeletal disease

challenges

• Data can be compared across time,

locations, and diagnosticians

Poultry health and beyond

38 ©2015 Elanco

Page 52: Animal Health A Durable Industry

Swine – Profit Optimizer Determining Optimal Target Weights

Model the most profitable target market weight for a pig group

What it is: Optimization model using

variation in weight, market conditions,

packer grid, and customized growth curves

to determine the most profitable target

weight for a group of pigs

Value:

• Producers are provided an optimum

target weight for maximum

profitability based on expected

future market conditions

• What-if scenarios can be performed

to evaluate multiple possible market

conditions

• Marketing decisions are based on

increasing overall profitability

rather than focusing on cost

39 ©2015 Elanco

Page 53: Animal Health A Durable Industry

1 2

Capability:

Dedicated Global

Market Access Team

Shaping Policy Helping Customers

Make Decisions

Capability:

Elanco Pulse

Institute

Market Access Creating Opportunities

Page 54: Animal Health A Durable Industry

©2015 Elanco

Market Access Helping Customers Make Decisions

41

Page 55: Animal Health A Durable Industry

Market Access Shaping Policy Example: Antibiotics 8 Point Plan

42

Page 56: Animal Health A Durable Industry

Value Beyond Product Summary

©2015 Elanco

1 2 3

Leading

Analytics

Capability

Market

Access

Creating

Opportunities

Strategic

Account

Management

Focus

43

Page 57: Animal Health A Durable Industry

Innovation Model

©2015 Elanco

Aaron Schacht Vice President, R&D

44

Page 58: Animal Health A Durable Industry

©2015 Elanco

30-50% of growth (2007-2014)

from new innovation

of Elanco’s combined revenue

and pipeline originated from

a Lilly molecule

1/3

Rich Pipeline To support growth through

2020 and beyond

Innovation Key to Past and Future Growth

Page 59: Animal Health A Durable Industry

• Human, animal fields largely operated separately

• Life sciences R&D has changed over time, allowing quicker

leverage of human product development

• Elanco sources innovation, talent and expertise from Lilly

with speed plus no associated transaction costs

• Lilly capabilities allow Elanco to efficiently enter into smaller,

fast growing markets including oncology and diabetes

• 19 projects working together are currently in development

or under consideration

©2015 Elanco

PAST

PRESENT

Lilly R&D Supports Elanco’s Strategy

46

Page 60: Animal Health A Durable Industry

©2015 Elanco

R&D Global Footprint

Recently announced closures

Larchwood, Iowa

(USA)

Vaccines R&D

Victoria, P.E.I.

(Canada)

Aqua R&D Hub

Greenfield, Indiana

(USA)

R&D Headquarters

Gaithersburg,

Maryland (USA)

Enzymes R&D

Greensboro, North Carolina

(USA)

New product development Sao Paulo

(Brazil)

R&D Hub

St. Aubin

(Switzerland)

Discovery and CAB1 R&D

Shanghai

(China)

R&D Hub

Kobe

(Japan)

R&D Hub

Cuxhaven/Hannover

(Germany)

Vaccines Research

Basel (Switzerland)

Chemistry, Tech

Development

Australia

R&D Hub

Yarrandoo

(Australia)

FAB2 R&D

47

Page 61: Animal Health A Durable Industry

Multi-Source Innovation Model

Rich and Growing Pipeline

Elanco

Novartis

Lilly External

• Successful multi-

source model in

place for 10 years

• Agnostic to

R&D source

• Variable vs fixed

spending - greater

agility

• Model includes all

necessary tools to

access innovation

• Remain partner

of choice

©2015 Elanco 48

Page 62: Animal Health A Durable Industry

Large Molecules Vaccines Small Molecules

Respiratory

Enteric

Mastitis

Metabolic

Parasiticide

Parasiticide

Dermatology

Pain/Surgical

Cardiovascular

Diabetes, Oncology

CKD, IBD

Pla

tfo

rm

Sp

ec

ies

U

nm

et

Nee

ds

©2015 Elanco

Focused R&D Efforts

Food Animal

Cattle Swine Poultry Fish

Companion Animal

Dogs Cats

49

Page 63: Animal Health A Durable Industry

Key R&D Platforms Delivering Growth And Further Diversification

©2015 Elanco

AQUA DAIRY

Mastitis

Control

$500M

Market

Opportunity

Sea Lice

Control

$200M

Market

Opportunity

ANTIBIOTIC

ALTERNATIVES

Anti-Inflammatory

Immune Modulators

Bio Therapeutics

Novel Vaccines

Enzymes

50

Page 64: Animal Health A Durable Industry

7 Key Products

2015 2016 2016 – 1H’17

Canine Ear Infection

Canine Heartworm

Approved in

Select

Countries

Dairy Immune Restoration

Food Animal:

Feed Additive

Food Animal:

Therapeutic

Aquaculture:

Parasiticide

Companion Animal:

Parasiticide

Potential Approval

in US and

Europe

51

Page 65: Animal Health A Durable Industry

• Novel biotech dairy product

• $500M global market opportunity

• Disruptive technology: Immune modulator (restores immune function)

Effective against broad range of organisms with reduced hassle

• Potential US and Europe approval in 2016

• Helps cows through the “Vital 90” period (60 days prior to calving and

30 days following)

• Helps manage Mastitis, the most common and costly disease in dairy cattle

• Imrestor Launch supported by Vital 90 analytics tool

Recently launched in 4 markets

Imrestor

Page 66: Animal Health A Durable Industry

Interceptor Chewable

• Chewable heartworm protection product

• Addresses $800M market globally

• Broader worm protection

• Chewable formula, convenient dosing

• Further broadens CA portfolio

• Proprietary chewable technology creates platform

for further chewable products

Launched in October 2015

©2015 Elanco 53

Page 67: Animal Health A Durable Industry

Osurnia Novel Formulation for Otitis Externa

In both the US and France,

Vets say owner

compliance is the biggest

challenge when treating

Otitis Externa.

Chronic, recurring

infections are also

challenging.

What are your main challenges or frustrations in treating Otitis Externa?

“Lack of owner

compliance in giving

the medications.”

“Compliance of the

owner to treat their pet

for the required time.”

“Owner

compliance with

treatment.”

“Recurrence once

meds have

stopped.”

• Launched August

2015

• $150M global market

opportunity

• 2nd most common

canine veterinary

diagnosis in US (canine

ear infection)

• Only FDA approved

product with just two

doses

• Same dose for any

dog, regardless of size

or weight

©2015 Elanco 54

Page 68: Animal Health A Durable Industry

Innovation Model Summary Rich Pipeline To Drive Growth

Pipeline expected to drive

2-4+ ppt of growth per year

through 2020

Imrestor

Interceptor

Osurnia

4 additional launches in 12-18 months

Vaccines Product

Line Extensions

Balanced Between

FA and CA

• Rich Pipeline Just

Beginning To

Launch

• Favorable Near

Term Visibility

• Significant 2H 2015

or 2016 Launches

• Combines Best of

Former Standalone

Elanco/Novartis

Projects

• Increasing

approvals to

sustain growth

beyond 2020 ©2015 Elanco

• Food Animal parasiticide

• Food Animal therapeutic

• Aquaculture parasiticide

• Companion Animal parasiticide

55

Page 69: Animal Health A Durable Industry

Manufacturing

©2015 Elanco

Steve Jenison Sr. Vice President, Manufacturing

56

Page 70: Animal Health A Durable Industry

Manufacturing Imperatives

©2015 Elanco

Reduce Costs

Footprint

CMO Consolidation

Lean Manufacturing

Support Elanco

Brand

Reliable Supply

and Consistent

High Quality

Supply is not a given in animal health

Page 71: Animal Health A Durable Industry

Manufacturing Facilities

Vaccine Manufacturing

Other Manufacturing

Recently Announced Closures

Former Novartis Sites

Vacaville, CA

Vaccines

Page 72: Animal Health A Durable Industry

Unique Manufacturing Approach Relative to Human Health

• Animal manufacturing separated

from human pharma

• Bring in animal health “lens”

with external recruiting

• Applying “fit for purpose”

standards to animal health

Page 73: Animal Health A Durable Industry

Breakdown of external spend categories, which

collectively represent 50% of manufacturing costs,

with related savings opportunity:

• Raw Materials

o New procurement process

• CMOs

o Consolidating CMO base

o Bias towards low-cost locations

• CMO Oversight

o Reducing oversight costs through consolidated CMO footprint

©2015 Elanco

Reducing Cost is a Critical Goal External Manufacturing Opportunities

60

Page 74: Animal Health A Durable Industry

Productivity Agenda to Raise Operating Margins

Procurement Actions

CMO Consolidation

CMO Oversight

Lean Manufacturing

Footprint Decisions

Support Optimization

Integration

Savings

Manufacturing

Actions

Support

Manufacturing Actions

Represent Half of

Margin Improvement

Through 2020

Additional

Savings

Through

2020+

2020+ 2015

©2015 Elanco

Page 75: Animal Health A Durable Industry

Financial Review

©2015 Elanco

Brian Kopp Vice President, Finance

62

Page 76: Animal Health A Durable Industry

Business Development, Financial Results and Outlook

©2015 Elanco

Business

Development

• Proven value and growth

• A component of our model

Transition Period

For growth and profitability

Positioned For

Mid-Long Term

Outperformance

Page 77: Animal Health A Durable Industry

©2015 Elanco

• Strategic endpoints

met

• Exceeding hurdle

rates

• Targeted for

capabilities

• Lilly leverage

• Successfully

growing acquired

assets

Business Development Proven Value and Growth Enabler

Implants and Analytics

Dairy

Vaccines

Europe

Enzymes

Vaccines

Analytics

Vaccines

Multiple Capabilities

2007

2011

2013

2009

2015

Business Development

64

Page 78: Animal Health A Durable Industry

Novartis 50% Greater Savings

©2015 Elanco

Engine For

Growth

Accelerated

Integration

Value Exceeding

Expectations

• Created integration

function

• Commercial integration

complete

• Pipelines combined

• 50% greater savings ($300M vs $200M)

• Accretive to earnings(1)

in 2015 vs 2016

• 5% YTD acquired

portfolio growth(2)

• Expanded commercial

footprint o 2nd largest in North America

and Asia Pac

o China #8 to #4

• Broader companion

portfolio

• Cow/calf vaccines

• Aquaculture

(1) Accretive to earnings on a cash basis, excluding integration costs

(2) Proforma, excluding impact of F/X

Business Development

65

Page 79: Animal Health A Durable Industry

Engine For

Growth

Integration

On Track

Value Exceeding

Expectations

Lohmann

©2015 Elanco

• Commercial integration

complete

• SAP implementation in

progress

• Divested nutritional

business

• Portfolio rationalized,

focused growth

strategy

• Strong product

demand

• Enhanced global poultry

position with vaccines

• U.S. and European

vaccine manufacturing

capability

• Established in Breeders

and Layers, growing in

Broilers

Business Development

66

Page 80: Animal Health A Durable Industry

2015-2016 Transition Period for Growth and Profitability

©2015 Elanco

• Disruption, competitive

dynamics

• YTD growth 38%(1)

• 1% organic (food animal

up 4%, companion animal

down 5%)

• Greater organic growth in

Transition Period For Growth…

Transition

2016(1) supported by new innovation and stable

organization, despite competitive headwinds

(1) Excluding impact of FX 67

Page 81: Animal Health A Durable Industry

©2015 Elanco

2015-2016 Operating Margins

Transition

• Acquired Novartis at essentially

breakeven levels

• Significant Operating Margin

improvement YTD

• Targeting 2016 OMs(1) near

pre-Novartis levels

◦ Accelerated integration

◦ Productivity

◦ Global scale

…While Profitability Improves

Elanco

2014 2015 (Q1) 2015 (YTD) 2016

26%

15%

19%

Low

to

Mid-

20%

Operating Margins(1)

(1) Operating margins exclude amortization of

intangibles related to acquisitions.

68

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Mid-Long Term Revenue Outperformance

©2015 Elanco

Outperformance

• Optimizing model and share of voice

• Vaccines, enzymes, CA therapeutics

• Leveraging value beyond product

capabilities

• Rich pipeline

• Multiple sources

• 2-4+ ppts of growth per year

through 2020

• Proven value and growth enabler

• Continue to be active in targeted areas

1

2

3

1

2

3

69

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Goal: upper 20% to 30% Operating Margins(1) by 2020

We Are Targeting Higher Margins

Integration Manufacturing Operating

leverage and

sales mix

50% greater

integration

savings

Productivity

agenda

Leverage

footprint

Elanco

2014 2015 (Q1) 2015 (YTD) 2016

26%

15%

19%

Low

to

Mid-

20’s

2020

High

20s

to

30%

Operating

Margins(1)

(1) Operating margins exclude amortization of intangibles related to acquisitions.

Revenue

Outperformance

Growth above

industry

Page 84: Animal Health A Durable Industry

Elanco Margin vs Industry Scale Includes Efficiency Advantages

Elanco(2) $3.4B

in Sales (Top 3) Remaining Top 10

AH Companies,

Excluding Zoetis

EBIT

MARGINS

YTD 19%

11-21%

in 2014(1)

Low to Mid-20%

in 2016

Heading to

30%+

(1) Source: Vetnosis: Income Statements FY 2014 report (April 2015)

(2) EBIT margins exclude amortization of intangibles from acquisitions. 71 ©2015 Elanco

Page 85: Animal Health A Durable Industry

Why Not Be More Aggressive With Margins?

There are structural differences in

margins between Elanco and Zoetis

1. Sales mix, primarily vaccines

2. Scale

• Our 2020 goal of high 20’s to 30% OMs(1)

would fall in the top tier in animal health

• Nonetheless, we are striving for greater

efficiency, beyond our 2020 goals

• We will continue to invest in the

business in order to outgrow the industry

• Our track record suggests this is a

successful long term model

Vaccines

• Elanco (8% of sales) vs Zoetis (27%)

• Vaccines have higher margins (typically

high 60’s to mid 70’s gross margins)

Scale

• Zoetis 40% larger than Elanco

(1) Operating margins exclude amortization of intangibles related to acquisitions.

Page 86: Animal Health A Durable Industry

©2015 Elanco

$300M integration savings in 3 years is minimum

commitment (vs $200M in 3 years)

Low to Mid 20’s OMs by 2016 (vs Mid 20’s by

2017-2018)

Rich pipeline to contribute 2-4+ ppts

to growth through 2020

Outgrow industry revenue over mid-long term

Our Commitments

73

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Q&A

Elanco Management Team

©2015 Elanco

?

74

Page 88: Animal Health A Durable Industry

Key Messages

©2015 Elanco

What Should Investors Expect of Elanco

Growth and improving profitability

Proven Track Record, Proven Strategy

How Elanco has become a top 3 player in attractive

animal health industry

Future Sustainable Outperformance

Driven by the right model and key differentiators

75

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Today’s Presenters

©2015 Elanco 76

Page 90: Animal Health A Durable Industry

Jeff Simmons President, Elanco

©2015 Elanco

Jeff Simmons is President of Elanco, the animal

health division of Eli Lilly and Company.

As part of this role, he is also a Senior Vice President and

Executive Officer of Lilly. Elanco is an innovation-driven company

with offices in more than 75 countries and sales over $3 billion.

The company is committed to protein production, companion

animal health and food safety, with an emphasis on helping the

food industry produce a safe and affordable food supply.

In more than two decades with the company, Simmons has held

a number of sales, marketing and management positions, in the

United States and abroad, including serving as country director in

Brazil and area director for West Europe based in the U.K.

77

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Eric Graves VP of Integration Planning for the Novartis Acquisition, Elanco

©2015 Elanco

Eric Graves is Vice President of Integration Planning for

the Novartis Acquisition. He joined Elanco, the animal health

division of Eli Lilly and Company, in 2003 and has held a range of

roles and responsibilities.

Prior to his current role, he was Elanco’s Chief Marketing Officer and

was responsible for all aspects of marketing for Elanco’s existing and

new products and brands. Previously, he led Elanco’s launch into the

companion animal market, where he enjoyed being part of building a

team and business that created growth and value for customers. Part

of this time he was based in Europe, working on the global

companion animal health business with additional emphasis on

integrating a previous acquisition.

Prior to joining Elanco, Eric served as a director of veterinary

marketing at Hill’s Pet Nutrition, Inc., a division of Colgate-Palmolive.

He has also held a variety of positions in companion animal

marketing, sales and operations at both Merial and Merck Agvet.

78

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Tony Ezell VP, Chief Marketing Officer, Elanco

Tony Ezell is Vice President and Chief Marketing Officer

of Elanco. Ezell joined Lilly in 1992, and over his 23 years has

held many roles in sales, marketing and general management. From

1999 to 2007, Ezell held various leadership positions including

executive director of marketing for the endocrine business unit, as

well as business unit leader of the US acute care business.

In more recent years Ezell has been a leader in Lilly’s market

research organization where he first served as executive director of

market research for Lilly USA. In 2009, Ezell was promoted to vice

president, global market research, and in November 2012 he was

promoted to chief customer officer Eli Lilly and Company. As chief

customer officer, he was responsible for leading Lilly’s enterprise

level customer experience strategy as well as delivering on Lilly’s

marketing and market research capability strategy. His focus was on

ensuring the company consistently connects innovative science with

relevant customer experiences necessary to deliver on both our

product and corporate brand promises.

79 ©2015 Elanco

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Aaron Schacht VP, Global Research and Development

©2015 Elanco

Aaron Schacht is Vice President for Global Research and

Development at Elanco Animal Health. Prior to this, he was

the Global Brand Development Leader – Pain in Lilly Biomedicines.

He was the global leader for product development and

commercialization activities for LY951742 – Lilly’s novel CGRP

neutralizing antibody. In 2012, Schacht joined Lilly Biomedicines as

Senior Advisor – Strategy & Business Development for Lilly

Biomedicines. His responsibilities included oversight of Therapeutic

Strategy development, R&D Portfolio Management, and Business

Development for Lilly BioMedicines – Lilly’s largest business unit.

Past roles included serving as Executive Director, Global External

R&D, at Eli Lilly and Company, where he was responsible for

implementation of strategies which aim to leverage novel approaches

to external partnerships as well as Executive Director of LRL Strategy,

Portfolio Management and Project Management. In 2002, during a

short leave from Lilly, Mr. Schacht was co-founder, President and

CEO of Artesian Therapeutics, a Gaithersburg, MD cardiovascular

drug discovery start-up.

80

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Steve Jenison Senior VP of Elanco Manufacturing

Stephen H. Jenison is Senior Vice President of Elanco

Manufacturing. He oversees internal manufacturing operations

at sixteen facilities in eleven countries. In addition, he oversees

Elanco’s global external manufacturing operations and supply

chain organizations.

Jenison joined Lilly in 1986 as a technical service representative in

Clinton Laboratories. He also held positions at Clinton as financial

analyst and department head of chemical operations prior to

becoming manager – North East Regional distribution center in 1990.

In 1991, he was named the development projects manager in Lilly Research Labs for Gemzar.

Jenison moved to Mayaguez, Puerto Rico in 1992 as the site head. In 1995 he returned to

various manufacturing strategy roles with the global business units and product teams. From

2004-2009 Steve was the Vice President and Manufacturing Information Officer for Global

Manufacturing. In 2010, he began a dual reporting relationship to both Manufacturing and

Emerging Markets. During that position he served as the Vice President of Emerging Markets

and External Drug Product Operations. Prior to joining Lilly, Jenison held various positions in

the inorganic chemicals industry.

Page 95: Animal Health A Durable Industry

Brian Kopp CFO and VP of Strategy and Operations, Elanco

©2015 Elanco

Brian Kopp is Vice President and CFO, and head of

several Elanco capability areas including business

development, alliance management, communications,

IT, strategy and operations.

Kopp has been with Eli Lilly and Company for 18 years, holding a

variety of positions: Director and Sr Director, finance, Lilly USA

Pharmaceutical Ops Manager, Corporate Strategy and Planning Sr.

Analyst, corporate finance and Investment Banking.

Prior to joining Eli Lilly and Company, Kopp worked in various

financial and business development roles at General Motors

Corporation, including capital planning and manufacturing, as well as

international treasury and business development support, primarily

focused on Latin America.

82

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©2015 Elanco

Appendix:

Elanco Product

Examples

83

Page 97: Animal Health A Durable Industry

AviPro Vaccine

©2015 Elanco

AviPro – salmonella vaccine for poultry

• Live vaccine that aids in the reduction of Salmonella

Typhimurium, Salmonella Enteritidis and Salmonella

Heidelberg colonization of the internal organs of young

growing chickens

• Reduction of S. Enteritidis colonization of the crop,

intestinal tract and ceca of pullet chickens

84

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Hemicell

©2015 Elanco

Hemicell – enzyme for poultry

and swine

Most enzyme products are energy-releasing enzymes –

they “open up” feed components the animal is unable to

access on its own. Hemicell is different – it is a unique

and patented energy-sparing enzyme. By breaking

down β -mannans in soybean meal, Hemicell minimizes

the metabolizable energy (ME) loss caused by the FIIR

from β -mannans, allowing more energy to be available

for growth and performance.

• In a 42-day trial of 1,280 male broilers, compared to

control, birds fed a diet that included Hemicell

demonstrated:

• 2.4% improvement in weight gain

• 1.05% better feed conversion

• 2.6% advantage in weight adjusted feed conversion 85

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Micotil

©2015 Elanco

Micotil – for treatment of BRD and

ORD in cattle

A proven cattle treatment for Bovine Respiratory

Disease (BRD) and Ovine Respiratory Disease

(ORD)

• Long-lasting treatment with flexible, cost-effective

dose range for both metaphylaxis and individual

pull-and-treat therapy

• Flexible dose range allows stocker and feedlot

producers to more effectively manage animal

weight and risk variation within a truckload of

incoming cattle

86

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Milbemax

©2015 Elanco

Milbemax – for treatment of internal

parasites, roundworm, hookworm and

tapeworm, in dogs

• Milbemycin oxime (one of active ingredients) interferes

with nerve transmission in invertebrates, which helps

protect against heartworm, roundworm, etc.

• Praziquantel (other active ingredient) causes muscle

spasm in tapeworm, which then disintegrate. It kills all

intestinal forms of tapeworm except Spirometra spp,

which require a higher dosage than standard dose

rate.

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Optaflexx

©2015 Elanco

Optaflexx – Beta agonist for cattle

• Optaflexx is a beta-agonist that allows cattle

feeders to optimize both live and carcass

performance in order to easily respond to

market signals and the Choice-Select spread

• A feed ingredient that increases live weight

gain 22 lbs and hot carcass weight 20 lbs

when fed to steers at 300 mg/hd/d for the last

28 to 42 days of finishing

88

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Onsior

©2015 Elanco

Onsior – pain management for both

cats and dogs.

• Onsior persists at the site of inflammation long after

it has been cleared from the blood, therefore

providing effective pain relief with just once-daily

dosing

• Onsior is tissue-selective, effective, well-tolerated,

palatable, and convenient

• Its short blood half-life spares highly perfused

organs such as the liver, kidneys, and the GI tract

from prolonged exposure to effective drug

concentrations

89

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Posilac

©2015 Elanco

Posilac - dairy supplement

A healthy cow supplemented with

Posiliac produces an average of 10

more pounds of milk per day.

• Dairy producers supplement cows with Posiliac to

help produce a little more milk while using few

resources. And a little more milk means a more

successful dairy business and more abundant

food supply for an ever-growing global population.

• The added productivity that Posiliac allows

reduces your cost of production by 3-5%, or

approx. $0.50-$1.50/cwt.

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Rumensin

©2015 Elanco

Rumensin – feed additive for

prevention and control of coccidiosis

in beef and dairy cattle

• Since 1976, cattle producers have relied on

Rumensin to improve feed efficiency and prevent

and control coccidiosis

• For 35 years, Rumensin has demonstrated proven

results and continuous innovation, adding more

profit potential to the bottom line

• Rumensin is a cost-effective feed additive that

improves feed efficiency by providing more energy

from the ration. Research demonstrates that

Rumensin improves feed efficiency by 4 percent and

provides a net return of $23.13/hd

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Trifexis

©2015 Elanco

Trifexis – A monthly chewable tablet for

dogs that provides three types of

parasite protection

• Trifexis kills fleas and prevents infestations, prevents

heartworm disease, and treats and controls adult

hookworm, roundworm and whipworm infections

• Trifexis is a beef flavored tablet that starts killing fleas

in 30 minutes

• There is no need to isolate the dog from pets or

children; pet owners can interact with their dog

immediately after treatment

• Safe for dogs and puppies 8+ weeks and 5+ lbs

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Vira Shield

©2015 Elanco

Vira Shield – vaccine for use in

breeding cattle

• Breeding cattle includes pregnant cows and

heifers

• Aids in prevention of disease caused by infectious

bovine rhinotracheitis (IBR), bovine virus diarrhea

(BVD Type 1 and BVD Type 2), parainfluenza Type

3, and bovine respiratory syncytial (BRSV) viruses

and Campylobacter fetus, Leptospira canicola,

grippotyphosa, hardjo, icterohaemorrhagiae, and

pomona.

93

Vira Shield