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Animal Care & Use Program (ACUP) Quarterly Informational Meeting
August 24, 20211:30pm CST via Zoom
ACUP Updates
Effective August 2, 2021
Out of an abundance of caution and until further notice, the animal research facilitiesare to be considered public (non-clinical) locations and corridors. As per VUMCguidance, masking is required for all persons, regardless of vaccination status,entering these areas.
Masks should be worn at all times, regardless of vaccination status,
while working in the animal facilities, even when working alone.
If you have any questions or concerns, please talk to your Facility Manager or Facility Veterinarian.
Welcome
Courtney Hunter, PhD, DVMClinical VeterinarianInstructor, Division of Comparative Medicine, PMI
Clinical Assignment: ◦ MCN I◦ IAF◦ PRB◦ ESB
Welcome
Aleaya Bowie, DVMVeterinary Resident
Welcome
Jessica HuntCage Wash Manager
Lab Animal Medicine Residency Program Overview
LAM Residency Program
• Laboratory animal medicine residency program recognized by the American College of Laboratory Animal Medicine (ACLAM)
• 2-year post-doctoral program for veterinarians
• Training includes• Clinical Practice / Rotations• Lectures and Seminars• Research Project
LAM Residency Program
• Started in July 2012
• Recent Graduates• Dr. Kelsey Finnie – UTK (Knoxville, TN) • Dr. Julie Holdridge – NIH- NCI (Bethesda &
Frederick, MD)
• Current Residents• Senior resident: Dr. Michael McKinney• Junior resident: Dr. Aleaya Bowie
Dr. Michael McKinney Hometown: Knoxville, Tennessee
Education: BS Animal Science & DVM, The Ohio State University
Hobbies: Hiking, fishing, basketball
Pet: Monkey
Current Rotation (8/2 to 12/31) - MCN I, IAF, & MMPC
If veterinary medicine was not an option, the career I would choose would be:
Personal Trainer
Dr. Aleaya Bowie Hometown: Frederick, Maryland
Education: BS Biology, University of Maryland Eastern ShoreDVM, North Carolina State University
Hobbies: Reading, watching TV
Pet: Guapo – 3yo male Chiweenie (Dachshund-Chihuahua mix)
Current Rotation (8/2 to 10/22) - MCN II 7th & 8th Floors
If veterinary medicine was not an option, the career I would choose would be:
Forensic Psychologist
New ACUP WebsiteComing Soon!
IACUC/OAWA Updates
DEA Inspections – Let OAWA KnowIf the DEA shows up for an inspection:◦ Inform ACUP Administrative Office at 615-322-2231◦ Complete visitor forms if accessing animal facility
◦ Representative to assist upon request
◦ Ask to see the DEA Inspector’s “Notice of Inspection” (NOI) and badge
◦ Confirm inspector is with DEA by calling the DEA Diversion Group Supervisor at 615-736-2560
◦ Answer all questions truthfully
Mandatory USDA Meetings
All Principal Investigators that use USDA Regulated Species for research are requiredto attend one of the following mandatory meetings.
• Thursday, August 26, 2021 2:00pm Zoom• Tuesday, August 31, 2021 11:00am Zoom• Thursday, September 9, 2021 11:00am Zoom
**Laboratory Staff are highly encouraged to attend
Please contact the Office of Animal Welfare Assurance 615-936-8163 with questions
July 2021 IACUC Semi-Annual Inspections
Thank you for adapting to the scheduled inspections and your help with maintaining appropriate physical distancing.
Top Items of Non-compliance from July 2021
Recordkeeping
Expired Items
Vanderbilt University Medical CenterJuly 2021 Semi Annual Inspection
Deficiency Category Minor Significant Total
Animal Welfare 5 - 5
Expired Items 22 - 22
Recordkeeping 25 - 25
Physical Plant 13 - 13
Cleaning/Sterilization 10 - 10
Safety Concerns 2 - 2
Other 6 - 6
TOTALS 83 - 83
5
22
25
13
10
26
22 8 15 6 8 15 10 15 7 3 6
1512
1513 10 9 10
17 208
2
511
127 5
3223
2046
6
2010
3125
59
14 31
4037
4942
10
24
13
3231
37
37 23
37 7054
68
20
50
25
2631
35
48 36
5648 31
39
13
21
22
1322
15
2321
34 2021
19
11
13
5
144 140
188
148134
223 218207
241
60
139
83
0
50
100
150
200
250
16-Jan 16-Jul 17-Jan 17-Jul 18-Jan 18-Jul 19-Jan 19-Jul 20-Jan 20-Jul 21-Jan 21-Jul
VUMC/VU Deficiencies by Category
TotalAnimal WelfareExpired ItemsRecordkeepingPhysical PlantCleaningSafetyOther
Vanderbilt University Medical CenterJuly 2021 Semi Annual Inspection
Historic High = 572 deficiencies July 2007
# of
Def
icie
ncie
s
Veterans Administration - TVHSJuly 2021 Semi Annual Inspection
Deficiency Category Minor Significant Total
Animal Welfare 0 - 0
Expired Items 1 - 1
Recordkeeping 2 - 2
Physical Plant 3 - 3
Cleaning/Sterilization 0 - 0
Safety Concerns 2 - 2
Other 0 - 0
TOTALS 8 - 8
1
2
3
2
2 1 14 2 41
7
1
3
2 1
1
25
32
1 2
20
7
19
3
2
2 3
13
23
1
3
3
5
3
4 3
2
22
4 2
3
4
7
3
15
2
6 2 1
2
2
1
4
30
19
40
15
30
1311 10 9
5
9 8
0
5
10
15
20
25
30
35
40
16-Jan 16-Jul 17-Jan 17-Jul 18-Jan 18-Jul 19-Jan 19-Jul 20-Jan 20-Jul 21-Jan 21-Jul
VA Deficiencies by Category
TotalAnimal WelfareExpired ItemsRecordkeepingPhysical PlantCleaningSafetyOther
Veterans Administration - TVHSJuly 2021 Semi Annual Inspection
Historic High = 72 deficiencies July 2007
# of
Def
icie
ncie
s
New SOPs & Policies
POL.AWEL.23 – Food and Water Provision for Research Animals“…all personnel working with research animals must assure that animals have access to food and water at all times, except as allowed by IACUC-approved exceptions or specific Division of Animal Care (DAC) policies. Failure by research personnel to assure access to food and/or water to animals will be subject to IACUC oversight and may result in measures up-to and including suspension of research activities.”
New SOPs & PoliciesPOL.AWEL.23 – Food and Water Provision for Research Animals
Why is this a problem?
Cage left on cart overnight without access to water
Reviewed SOPs & PoliciesTriennial Reviews
• POL.ADM.02 – Final Disposition of Animals Used in Research• POL.AWEL.02 – Expired Medical Materials in Research• POL.AWEL.04 – Hand Catching of Awake NHPs• POL.AWEL.07 – Food Fluid Regulation
ARIES TIP: Triennial De novo Review- Federal regulations state that protocols can be approved for a max. of 3 years, after which point a new
protocol must be submitted for a full review
- There is no mechanism for “renewal,” only “de novo” review
- The new protocol is reviewed as if it was a new submission- Previously approved procedures may generate questions as guidance changes, further clarification is
needed, there are changes/updates in ARIES (e.g. formulary updates), or issues from the original review are identified for refinement
- The ARIES copy/clone function is intended to allow PIs to keep or generate new numbers, and to ease burden by not requiring a full re-write. Do not clone/copy and resubmit without a full revision, this will result a greatly extended review process
- Additional advice:- Update numbers to reflect completed work/aims- Contact OAWA with any questions prior to submission, we are happy to consult with authors
Operations Updates
Facility Orientations/Tours
Enrollment for ACUP Facility Orientation/Tour is limited due to physical distancing requirements.
• Are you a VUMC Employee?Go to https://learningexchange.vumc.org/ to be directed to the correct Learning Exchange and search for the course title using keyword "ACUP"
• Are you a VU Employee?Go to https://vumc.myabsorb.com/ to be directed to the correct Learning Exchange and search for the course title using keyword "ACUP".
If you have any difficulty self-enrolling, email [email protected]. Please include your full name, VUMC.org or Vanderbilt.edu email, and VUMC ID or VUnet ID so that we can verify and/or update your user status.
Incoming & Outgoing Shipping IssuesShipments to and from non-commercial vendors are experiencing delays due to available transport. Multiple issues are contributing to the issue.
One commercial airline available for domestic shipments
Shortage of staff at both airlines and airline hubs (COVID-19 related)
Reduced flights (COVID-19 related)
Extreme temperatures
Ground transport is a viable option for urgent shipments, cost dependent on mileage and crate count.
During this time, we appreciate patience and ensure all shipments will be completed as quickly and safely as possible.
Veterinary/Clinical Updates
Reminder: Contact DAC Veterinarians if you experience any unanticipated adverse consequences resulting in animal welfare concerns or death. This is especially important when working with USDA species.
Timely Reporting Animal Health Issues is an Animal Welfare Issue
New Drug – Ethiqa XR Extended-Release Buprenorphine (Mice)
• Ethiqa XR now available – FDA Indexed extended-release buprenorphine
– Administered q 48 hours
– Available from Covetrus, Midwest Veterinary Supply, and MWI
– Similar to BupSR, but does not require veterinarian prescription
– DEA Registration & TN Board of Pharmacy License required for purchase
– Must be stored in a lock box in accordance with Vanderbilt and DEA requirements
Buprenorphine HCl—Dosing Change◦Buprenorphine HCl◦ Literature indicates that duration of action not as long in mice as previously
indicated◦ Appropriate frequency of administration is q 4-6 hours (4x
administration/day)
Impact on IACUC ProtocolsARIES Formulary has been updated
◦ New mouse protocols using buprenorphine will be required to select either Ethiqa XR (q 48 hr), Bup SR (q 48 hr), or Bup HCl at the new q 4-6 hour frequency of administration
◦ Amendments to mouse protocols with buprenorphine will require the same update
◦ All mouse protocols using Bup HCl must be updated by September 1, 2022
Administration & Ordering information posted on the ACUP website
Comparative Pathology Updates
Mission:The Translational Pathology Shared Resource will advance biomedical research and personalized medicine by providing investigators:
Immunohistochemistry, ISH & novel antibody
development
comparative pathology services: necropsy,
tissue collection
Laser capture micro-dissection
Automated tissue micro-array preparation
Clinical trial histology and pathologist
support
Research histology & Special stains
Comparative pathologist
support
Comparative Pathologist Support
• DVM, PhD, Board-Certified Veterinary Pathologists
• Aim to provide support from the beginning to end of studies
• Integration–understand project goals and experimental design advice
• Provide comprehensive reports • Interpretation, including qualitative, semi-
quantitative and whole slide digital image analysis
• Images & figures for presentations, posters, grants, and publications…
• Contribute to grant applications & manuscript preparation
• Utilize pathology to contribute to the model, pathogenesis and other biologically relevant questions including incorporating clinical, biochemical and gross pathology data
The next ACUP Quarterly Informational Meeting
November 18, 2021
