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ABBRUZZESE, ALBERTO Diparti.ento di Biochi.ica e Biofisica Universit~ di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY
ABU-ELHEIGA, L. Depart.ent of Molecular Biology Hebrew University, Hadassah Medical School P.O. Box 1172 Jerusalem, 91010 ISRAEL
AGOSTINELLI, ENZO Diparti.ento di Scienze Biochi.iche Centro di Biologia Molecolare del CNR Universit~ di Ra.a "La Sapienza" 00185 Rama, ITALY
ALHONEN, LEENA Depart.ent of Biocha.istry University of Kuopio P.O. Box 6
70211 Kuopio, FINLAND
ALISI, CHIARA Dipartt.ento di Biologia Vegetale Universit~ degli Studi di Ra.a "La Sapienza" Piazzale Aldo Moro, 5
00185 Ra.a, ITALY
ALTMAN, ARIE Otto Warburg Ctr. Biotechnol. in Agriculture The Hebrew University of Jerusala. P.O. Box 12
Rehovot, 76-100 ISRAEL
ALVES, PRAUKE Division of Gastroenterology • Endocrinology Depart.ent of Medicine Georg-August-University 3400 Gattingen, FRG
ANDERSSON, LEU C. Depart.ent of Pathology University of Helsinki 00380 Helsinki FINLAND
ANDREANA, AUGUSTO Diparti.ento di Terapia Medica I Facolt~ di Medicina Universit~ di Napoli 80134 Napoli, ITALY
ANGELINI, RICCARDO Diparti.ento di Biologia Vegetale Universit~ degli Studi di Ra.a "La Sapienza" Piazzale Aldo Moro, 5
00185 Roma, ITALY
ANTON, DAVID L. Central Research and Developaent E.I. du Pont de Neaours Co. Wilaington, DE 19898 USA
ASSARAF, Y.G. Depart.ent of Molecular Biology Hebrew University, Hadassah Medical School P.O. Box 1172 Jerusal .. , 91010 ISRAEL
BACCHI, CYRUS J. Haskins Laboratories Pace University 41 Park Row New York, NY 10038 USA
BACHRACH, URIEL Depart.ent of Molecular Biology Hebrew University, Hadassah Medical School P.O. Box 1172 Jerusal .. , 91010 ISRAEL
BAGNI, NELLO Departaent of Biology Institute of Botany Via Imerio, 42 40126 Bologna, ITALY
BAmlIROLI, BRUNO Cattedra di Biologia Molecolare Unlversit~ di Bologna Via Irnerio, 48 46126 Bologna, ITALY
769
BARKER, JACQUELINE H.A. Long Ashton Research Station
University of Bristol
Bristol, BS18 9AF
ENGLAND
BARNETT, GLENN R.
Department of Molecular Biology
and Biochemistry
University of California Irvine, CA 92717 USA
BASILION, JAMES P.
Department of Pharmacology
University of Texas
Medical School at Houston
Houston, TX 77225 USA
BASU, HIRAK S.
Brain Tu.or Research Center
Department of Neurological Surgery University of California, San Francisco
San Francisco, CA 94143 USA
BENINATI, SIMONE
Lab. of Cellular Development and Oncology
NIDR, National Institutes of Health Bldg. 30, Rm. 211
Bethesda, MD 20892 USA
BERGERON, RAYMOND J.
Department of Medicinal Chemistry
J. Hillis Miller Health Center
University of Florida
Gainesville, FL 32610 USA
BITONTI, ALAN J.
Merrell Dow Research Institute
2110 E. Galbraith Road Cincinnati, OH 45215 USA
BOWLIN, TERRY L.
Merrell Dow Research Institute
2110 E. Galbraith Road
Cincinnati, OH
45215-6300 USA
BROSNAN, MARGARET E.
Department of Biochemistry
Memorial University of Newfoundland
St. Johns, Newfoundland
AlB 3X9 CANADA
CACCIAPUOTI, GIOVANNA
Istituto di Biochimica delle Macromolecole
I Facolta di Medicina, Universita di Napoli
Via Costantinopoli, 16
80138 Napoli, ITALY
760
CALDARERA, CLAUDIO M.
Dipartimento di Biochimica
Universita di Bologna
Via Irnerio, 48
40126 Bologna, ITALY
CANDIANI, ROssELLA
Istituto di Patologia Generale, Universita, Centro Ricerca in Patologia Cellulare, CNR
Via Mangiagalli, 31
20133 Milano, ITALY
CANELLAKIs, E.s.
Department of Pharmacology
Yale University School of Medicine
New Haven, CT
06510-8066 USA
CANELLAKIs, ZOE NAKOS
Department of Pharmacology
Yale University School of Medicine
P.O. Box 3333
New Haven, CT 06510-8066 USA
CARRERA, CARLOS J.
Department of Basic and Clinical Research
Research Institute of Scripps Clinic
10666 North Torrey Pines Road
La Jolla, CA 92037 USA
CARSON, DENNIS A.
Department of Basic and Clinical Research
Research Institute of Scripps Clinic
10666 North Torrey Pines Road
La Jolla, CA 92037 USA
CARTENI'-FARINA, MARIA
Istituto di Biochimica delle Macromolecole
I Universita di Napoli
Via Costantinopoli, 16
80138 Napoli, ITALY
CAsTAGNINI, PAOLO Istituto di Chimica Biologica
Universita di Padova Via F. Marzolo, 3
35131 Padova, ITALY
CHATEL, M.
Groupe Recherche en Therap.Anticancereuse
Centre Hospitalier Universitaire
2. Ave. du Professeur Leon-Bernard
35043 Rennes Cedex, FRANCE
CHEN, H.J.
Department of Biological Sciences
and Chemistry
Northern Illinois University
DeKalb, IL 60115-2861 USA
CHIOCCA, ANTONIO Depart .. nts of Phar8acology and Medicine University of TeKas Medical School at Houston Houston, TX 77225 USA
CIMINO, GUIDO Istituto per la Chi.ica di lIolecole di Interesse Biologico, CNB Via Toiano, 6 80072 Arco Felice (Napoli), ITALY
CLAVERIE, NICOLE Merrell Dow Research Institute 16, rue d'Ankara 67084 Strasbourg Cedex FRANCE
CLEFFlIANN, ULRIKE Division of Gastroenterology & Endocrinology Departaent of Medicine Georg-August-University 3400 Gattingen, FRG
CLO', CARLO Diparti .. nto di Biochi.ica Facolta di Medicina e Chirurgia Via Irnerio, 48 40126 Bologna, ITALY
COHEN, PNINA Otto Warburg Ctr. Biotechnol. in Agriculture The Hebrew University of Jerusal .. P.O. Box 12 Rebovot, 76-100 ISRAEL
COLEMAN, CATHERINE S. Clinical Phar8acology Unit Depart.ent of Medicine & Terapeutics University of Aberdeen Aberdeen AB9 2ZD, SCOTLAND, UK
COLOMBATTO, SEBASTIANO Dipart. di Medicina e Oncologia Speriaentale Universita di Torino Via M. Buonarroti, 27 10126 Torino, ITALY
CONA, ALESSANDRA Diparti .. nto di Biologia Vegetale Universita degli Studi di Ra.a "La Sapienza" Piazzale Aldo Moro, 5 00185 Ra.a, ITALY
COURTHEOUX, P. Groupe de Recherche en Therapeutique Anticancereuse Centre Hospitalier Universitaire Caen, FRANCE
COWARD, JAMES K. Depts. of Ch .. istry and Medicinal Ch .. istry University of Michigan Ann Arbor, MI 48109-1055 USA
CREUTZFELDT, WERNER Division of Gastroenterology & Endocrinology Departaent of Medicine Georg-August-University 3400 Gattingen, raG
CROZAT, ANNE The Population Council and The Rockefeller University 1230 York Avenue New York, NY 10021 USA
DARCEL, F. Groupe Recherche en Therap.Anticancereuse Centre Hospitalier Universitaire 2, Ave. du Professeur Leon-Bernard 35043 Rennes Cedex, FRANCE
DAVIES, PETER J.A. Depart.ents of Phar8acology and Medicine University of Texas Medical School at Houston Houston, TX 77225 USA
DAVIS, ROWLAND H. Departaent of Molecular Biology and Bioche.istry University of California Irvine, CA 92717 USA
DE ROSA, MARIO Istituto di Biochi.ica delle Kac~lecole I Facolta di Medicina, Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY
DELLA RAGIONE, FULVIO Istituto di Biochi.ica delle Macro.olecole I Facolta di Medicina, Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY
DESIDERIO, ALPONSINA Istituto di Patologia Generale Universita di Milano Via Kangiagalli, 31 20133 Milano, ITALY
EISENBERG, LEONARD The Population Council and The Rockefeller University 1230 York Avenue New York, NY 10021 USA
761
ILOIlANTA, TIBHO Depart .. nt of Bioch .. istry University of Kuopio P.O. Box 6 70211 Kuopio, PINLAND
ISPOSITO, CARLA Diparti.ento di Biochi.ica e Biofisica I Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY
PAIBLAMB, ALAN H. Depart.ent of Medical Protozoology London School of Hygiene • Tropical Medicine Keppel Street London WC11 7HT, INGLAND
PASULO, LUISA Dipart. di Medicina e Oncologia Speri.entale Universita di Torino Via M. Buonarroti, 27 10126 Torino, ITALY
PIDIBICO, BODOLPO Diparti.ento di Biologia Vegetale Universita degli Studi di ao.a "La Sapienza" Piazzale Aldo Moro, 5 00185 ao.a, ITALY
PIBIOLI, MARIA ELENA Istituto di Patologia Generale, Universita, Centro Ricerca in Patologia Cellulare, CNB Via Mangiagalli, 31 20133 Milano, ITALY
PEBRO, ADOLPH J. Epitope Inc. 15425 S.W. Koll Parkway Beaverton, OR 97006 USA
PEUIBSTEIN, BURT G. Departments of Laboratory Medicine and Pediatrics University of california, San Prancisco San Prancisco, CA 94143 USA
PIOBETTI, MASSIMO Istituto di Biocht.ica delle Hacro.o1ecole I Pacolta di Medicina, Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY
PITCHEN, JOHN H. Medical Research Service Veterans Ad.inistration Medical Center P.O. Box 1034 Portland, OR 97207 USA
762
PLAKIGNI, FLAVIO Diparti.ento di Biochi.ica Universita di Bologna Via Irnerio, 48 40126 Bologna, ITALY
POLK, J.E. Lab. of Cellular Develop.ent and Oncology NIDB, National Institutes of Health Bldg. 30, ... 211 Bethesda, HD 20892 USA
POLSCH, ULRICH B. Division of Gastroenterology. Endocrinology Depart.ent of Medicine Georg-August-University 3400 GOttingen, PRG
PULGOSI, BARBABA Dipart. di Medicina e Oncologia Sperimentale Universita di Torino Via M. Buonarroti, 27 10126 Torino, ITALY
GALSTON, ARTHUR W. Department of Biology Yale University P.O. Box 666 New Haven, CT 06511 USA
GAHBACOBTA, AGATA Istituto per la Chimica di Molecole di Interesse Biologico, CNB Via Toiano, 6
80072 Arco Pelice (Napoli), ITALY
GAVAGNIN, MARGHEBITA Istituto per la Chi.ica di Molecole di Interesse B10logico, CNR Via Toiano, 6 80072 Arco Pelice (Napoli), ITALY
GEBHART, PRITZ Merrell Dow Besearch Institute 16, rue d'Ankara 67084 Strasbourg Cedex PIIANCE
GERNEB, EUGENE W. Department of Radiation Oncology and Bioch .. istry, University of Arizona Health Sciences Center Tuscan, AZ 85724 USA
GIPPIN, BRUCE P. Depart.ent of Biology University of Dayton 300 College Park Dayton, OH 45469-0001 USA
GOLENSIR, J. Departaent of Parasitology Hebrew University, Hadassah Medical School
P.O. Box 1172 Jerusala., 91010 ISRAEL
GONZALEZ-BOSCH, CARMEN Instituto Investigaciones Cito16gicas de la Caja de Ahorros de Valencia AIIadeo de Saboya, 4 46010 Valencia, SPAIN
GRAGNANIELLO, VINCENZO
Istituto di Biochimica delle Macromolecole I Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY
GRILLO, HARIA ANGELICA Dipart. di Medicina e Oncologia Speri.entale
Universita di Torino Via M. Buonarroti, 27
10126 Torino, ITALY
GRISOLfA, SANTIAGO
Instituto Investigaciones Cito16gicas de la Caja de Aborros de Valencia Amadeo de Saboya, 4 46010 Valencia, SPAIN
GUARNIERI, CARLO Diparti.ento di Biocht.ica Universita di Bologna Via Irnerio, 48 40126 Bologna, ITALY
GUEGAN, Y. Groupe Recherche en Th~rap.Anticanc~reuse Centre Hospitalier Universitaire 2, Ave. du Professeur Leon-Bernard 35043 Rennes Cedex, FRANCE
GYNTHER, JUKKA
Depart.ent of Phar.aceutical Cha.istry University of Kuopio 70211 Kuopio FINLAND
HAKIM, GABRIELE Dipartimento di Biochimica
Universita di Bologna Via Irnerio, 48
40126 Bologna, ITALY
HAMASAKI, NOBUKO
Depart.ent of Life Science Tokyo Institute of Technology Nagatsuta, Midori-Ku Yokoha.a 227, JAPAN
HAVOUIS, R.
Groupe Recherche en Th~rap.Anticanc~reuse Centre Hospitalier Universitaire 2, Ave. du Professeur Leon-Bernard 35043 Rennes Cedex, FRANCE
HAYASHI, SHIN-ICHI Department of Nutrition
The Jikei University School of Medicine Minato-KU Tokyo 105 JAPAN
HEBY, OLLE
Department of Zoophysiology University of Lund Helgonar 3 233 62 Lund, SWEDEN
HERNANDEZ-YAGO, JOSt
Instituto Investigaciones Cito16gicas de 1a Caja de Ahorros de Valencia
Amadeo de Saboya, 4 46010 Valencia, SPAIN
HICKOK, NOREEN J. The Population Council and
The Rockefeller University 1230 York Avenue New York, NY 10021 USA
HICKS, M.F.
Depart.ent of Biological Sciences and Chemistry
Northern Illinois University DeKalb, IL 60115-2861 USA
HIRVONEN, ARI
Department of Biochemistry University of Kuopio P.O. Box 6 70211 Kuopio, FINLAND
HOUl, INGVAR Depart.ent of Zoophysio10gy UniverSity of Lund Helgonar 3 233 62 Lund, SWEDEN
HOLTTX, ERKKI Depart.ent of Pathology
University of Helsinki 00380 Helsinki FINLAND
HSIEH, J.T.
Depart.ent of Human Oncology University of Wisconsin
Clinical Cancer Center Madison, WI 53792 USA
763
HU, YU-WAN Department of Biochemistry
Me.arial University of Newfoundland St. Johns, Newfoundland AlB 3X9 CANADA
HUANG, S.C.
Department of Phar.acology Yale University School of Medicine New Haven, CT 06510-8066 USA
HYVONEN, TAPANI Department of Biochemistry University of Kuopio P.O. Box 6
70211 Kuopio, FINLAND
IGARASHI, KAZUEI Faculty of Pharmaceutical Sciences Inohana Campus, Chiba University 1-8-1 Inohana Chiba City, 280 JAPAN
ITO, KIYOSHI Faculty of Pharmaceutical Sciences Inohana Campus. Chiba University 1-8-1 Inohana Chiba City, 280 JAPAN
JXNNE, JUHANI
Department of Bioch .. istry University of Kuopio P.O. Box 6
70211 Kuopio, FINLAND
JXNNE, OLL! A. The Population Council and The Rockefeller University 1230 York Avenue New York, NY 10021 USA
JXRVINEN, TOMI Department of Pharmaceutical Chemistry University of Kuopio 70211 Kuopio FINLAND
JULKUNEN, MERVI The Population Council and The Rockefeller University 1230 York Avenue New York, NY 10021 USA
KAJANDER, E. OLAVI Department of Biochemistry University of Kuopio
P.O. Box 6 70211 Kuopio, FINLAND
764
KALKKINEN, NISSE Depart.ent of Gene Technology University of Helsinki Valimotie 7 00380 Helsinki, FINLAND
KALLIO, ARJA Orion
Genetic Engineering Laboratory Helsinki FINLAND
KAMEJI, T.
Department of Nutrition
The Jikei University School of Medicine Minato-KU Tokyo 105 JAPAN
KANAMOTO, R. Depart.ent of Nutrition The Jikei University School of Medicine Minato-KU Tokyo 105 JAPAN
KASHIWAGI, KEIKO Laboratory of Biochemical Pharmacology
NIDDKD, National Institutes of Health Bldg. 8, Rm. 223
Bethesda, MD 20892 USA
KAUPPINEN, LEILA Department of Biochemistry University of Kuopio P.O. Box 6
70211 Kuopio, FINLAND
KIERSZENBAUM, FELIPE Cellular I .. unology ~ I .. unoparasitology
Department of Microbiology ~ Public Health Michigan State University East Lansing, MI 48824-1101 USA
KRAKAMP", BERNHARD
1st Medical Clinic University of Cologne 5000 Koln-Merheim GERMANY
KUBOTA, HASARU
Department of Basic and Clinical Research Research Institute of Scripps Clinic 10666 North Torrey Pines Road La Jolla, CA 92037 USA
KUCAN, !'ELJKO
Department of Chemistry, Faculty of Science University of Zagreb Strossmayerov trg, 14
41000 Zagreb, YUGOSLAVIA
KULOHAA, HARKKU Depart.ent of Biomedical Sciences University of Taapere
P.O. Box 607 Taapere, 33101 FINLAND
KUSCHE, JURGEN Dr. Madaus GmbH & Co. Ostmerheimer Str.198
5000 Koln-9l GERMANY
KUTNY, RUSTY Central Research and Develo~ent E.I. du Pont de Nemours Co.
Wilmington, DE 19898 USA
KYRIAKIDIS, D.A. Laboratory of Biochemistry Faculty of Chemistry
University of Thessaloniki
Thessa1oniki, GREECE
LAPINJOKI, SEPPO Department of Pharmaceutical Cheaistry University of Kuopio
70211 Kuopio
FINLAND
LEISTEN, LOTHAR Department of Surgery University of Cologne
5000 Koln-Merhei.
GERMANY
LEVIN, NITSA Otto Warburg Ctr. Biotechnol. in Agriculture The Hebrew University of Jerusale.
P.O. Box 12 Rehovot, 76-100 ISRAEL
LIGUORI, V. Dipartimento di Biochi.ica e Biofisica
Universita di Napoli Via Costantinopoli, 16
80138 Napoli, ITALY
LINNALA-KANKKUNEN, ANNIKKA Department of Biochemistry University of Kuopio
P.O. Box 6 70211 Kuopio, FINLAND
LORENZINI, ERMA CECILIA Istituto di Patologia Generale, Universita,
Centro Ricerca in Pato1ogia Cellu1are, CNR Via Mangiagalli, 31
20133 Milano, ITALY
LOSER, CHRISTIAN
Division of Gastroenterology & Endocrinology Department of Medicine Georg-August-University
3400 GOttingen, FRG
MALORNI, A.
Istituto per 1a Chi.ica di Molecole di Interesse Biologico, CNR Via Toiano, 6
80072 Arco Felice (Napoli), ITALY
MAHONT, PIERRE S.
Merrell Dow Research Institute 16, rue d'Ankara
67084 Strasbourg Cedex FRANCE
/ MARCOTE, MARIA-JESUS Instituto Investigaciones Cito16gicas de la Caja de Ahorros de Valencia Amadeo de Saboya, 4 46010 Valencia, SPAIN
MARINO, GENNARO
Istituto di Chimica Organica e Biologica I Universita di Napoli
Via Mezzocannone, 16
80134 Napoli, ITALY
MARM I ROLl , SANDRA
Dipartimento di Biochimica
Universita di Bologna Via Irnerio, 48
40126 Bologna, ITALY
MARTON, LAURENCE J.
Dept. of Laboratory Medicine, and Brain Tumor Research Ctr, Dept. Neurolog. Surgery
University of California. San Francisco San Francisco, CA 94143 USA
MATSUFUJI, S.
Department of Nutrition
The Jikei University School of Medicine Minato-KU Tokyo 105 JAPAN
McCANN, PETER P.
Merrell Dow Research Institute 2110 E. Galbraith Road
Cincinnati, 08
45215 USA
MEGGIO, FLAVIO
Dipartimento di Chimica Biologica Universita di Padova
Via F. Marzolo, 3 35131 Padova, ITALY
765
KELANITOU, EVlE The Population Council and
The Rockefeller University 1230 York Avenue New York, NY 10021 USA
KENNINGEN, RUDOLF Departaent of Surgery University of Cologne 5000 K6ln-Kerhei. GERIfANY
IfETAFORA, SALVATORE International Institute of Genetics and Biophysics, cn Via lfarconi, 10 80125 Napoli, ITALY
KEZZETTI, GABRIELE Istituto di Chi.ica Biologica UniversitA di Kodena Via Campi, 287 41100 Modena, ITALY
MILLER, RICHARD L. Wellcome Research Laboratories 3030 Cornwallis Road Research Triangle Park NC 27709 USA
MINOCHA, SUBHASH C. Depart.ent of Botany and Plant Pathology University of New Hampshire Durba., NH 03824 USA
MIRALLES, VICENTE J.
Instituto Investigaciones Cito16gicas de la Caja de Ahorros de Valencia ~deo de Saboya, 4 46010 Valencia, SPAIN
KITCHELL, John L.A. Depart.ent of Biological Sciences and Ch_istry Northern Illinois University DeKalb, IL 60115-2861 USA
HONDOVI " BRUNO
Diparti.ento di Scienze Biochi.iche Centro di Biologia Ifolecolare del cn UniversitA di Ra.a "La Sapienza" 00185 Ra.a, ITALY
KONTI, KARIA GIUSEPPINA Istituto di Cht.ica Biologica UniversitA di Kodena Via Campi, 287 41100 Hodena, ITALY
766
!fORBIS, DAVID R. Depart.ent of Bioch .. istry University of Washington J405 Health Sciences Bldg., SJ-70 Seattle, WA 98195 USA
!fORUZZI, KARIA STELLA Istituto di Chi.ica Biologica UniversitA di Kodena Via Campi, 287 41100 Kodena, ITALY
MOULINOUX, JACQUES-PHILIPPE Groupe Recherche en Th'rap.Anticanc'reuse Centre Hospitalier Universitaire 2, Ave. du Professeur Leon-Bernard 35043 Rennes Cedex, FRANCE
MULLER, SYLKE Bernhard-Nocht-Institut fur Tropen.edizin Abteilung fur Bioch .. ie Bernhard-Nocht-Strasse 74 2000 Hamburg-4, GERlfANY
MURAKAMI, Y. Depart.ent of Nutrition The Jikei University School of Medicine Hinato-KU Tokyo 105 JAPAN
MURPHEY, ROBERTA J. Depart.ent of Radiation Oncology and Bioch .. istry, University of Arizona Health Sciences Center Tuscon, AZ 85724 USA
MUSTELIN, TOKAS Scripps Clinic and Research Institute 10666 North Torrey Pines Road La Jolla, CA 92037 USA
NADEL, BARRY
Otto Warburg Ctr. Biotechnol. in Agriculture The Hebrew University of Jerusal .. P.O. Box 12 Rehovot, 76-100 ISRAEL
NARANDA, TATJANA
Depart.ent of Ch .. istry, Faculty of Science University of Zagreb Strosa.ayerov trg, 14 41000 Zagreb, YUGOSLAVIA
NISHIYAIfA, H. Depart.ent of Nutrition The Jikei University School of Medicine Hinato-KU Tokyo 105 JAPAN
NOBORI, TSUTOHU Departaent of Basic and Clinical Research Research Institute of Scripps Clinic 10666 North Torrey Pines Road
La .Jolla, CA 92037 USA
NOTHIG-LASLO, VESNA Rugjer Boskovic Institute Bijenicka cesta 54 41000 Zagreb YUGOSLAVIA
NOVILLO, KARIA CRISTINA Istituto di Cht.iea Biologiea Universit~ di Padova Via F. Karzolo, 3 35131 Padova, ITALY
NUTTALL, KAIIK E.
Clinical Pbaraacology Unit Depart.ent of Hedicine & Terapeutics University of Aberdeen Aberdeen AB9 2ZD, SCOTLAND, UK
OGASAWARA, TOSHIHIRO Faculty of Pbaraaceutical Sciences lnobana C.-pus, Chiba University 1-8-1 Inobana Chiba City. 280 JAPAN
OLIVA, ADRIANA Istituto di Biocht.ica delle Hacroaolecole I Facolt~ di Hedicina, Universit~ di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY
OSHIMA, TAIRO Departaent of Life Science Tokyo Institute of Technology Nagatsuta, Hidori-Ku Yokoba.a 227, .JAPAN
PAJUNIN, ANTTI Depart.ent of Bioch"istry University of Oulu LilllUl.-aa 90570 Oulu, FINLAND
PALIIKBO, ROSANNA Istituto di Biocbi.ica delle Kacroaolecole I Facolt~ di Hedicina, Universi~ di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY
PANAGIOTIDIS, C.A. Depart.ent of Pbaraacology Yale University School of Medicine New Haven, CT 06510-8066 USA
PAlIK, IlYUNG HEE Lab. of Oral Biology and Physiology NIDR, National Institutes of Health BIdS 30, .. 211 Bethesda, KD 20892 USA
PIGG, ANTHONY E. Departaent of Physiology Hilton S. Hershey Hedieal Center Pensylvania State University Hershey, PA 17033 USA
PERIN, ANTONIO Istituto di Patologia Generale Universi~ di Hilano Via Kangiasalli, 31 20133 Hilano, ITALY
PERSSON, LO Departaent of Physiology University of Lund Helgonar 3 233 62 Lund, SWEDIN
PES SA , TIINA Depart.ent of Pathology University of Helsinki 00380 Helsinki FINLAND
PICCININI, GIORGIO Istituto di Cht.ica Biologica Universit~ di Modena Via c..pi, 287 41100 Hodena, ITALY
PINNA, LORINZO A. Diparti .. nto di Cht.ica Biologiea Universit~ di Padova Via F. Karzolo, 3 35131 Padova, ITALY
PISTOCCHI, ROSSELLA Depart .. nt of Biology Institute of Botany Via Imerio, 42 40126 Bologna, ITALY
PLOHL, HIROSLAV Rugjer Boskovic Institute Bijenicka cesta 54 41000 zasreb YUGOSLAVIA
PODDAR, SUSltITA Departaent of Pbaraacology University of Texas Hedical School at Houston Houston, TX 77225 USA
767
PONG, R.C. Depart_ent of Huaan Oncology University of Wisconsin
Clinical Cancer Center Madison, WI 53792 USA
PONTON I , GABRIELE Istituto di Biochimica delle Macromolecole I Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY
PORCELLI, MARINA Istituto di Biochi.ica delle Macromolecole I Facolta di Medicina, Universita di Napoli
Via Costantinopoli, 16 80138 Napoli, ITALY
PORTA, RAFFAELE Dipartimento di Biochimica e Biofisica
I Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY
PORTER, CARL W. Grace Cancer Drug Center
Roswell Park Memorial Institute 666 Elm Street Buffalo, NY 14363 USA
PRAKASH, NELLIKUNJA J. Merrell Dow Research Institute
2110 E. Galbraith Road Cincinnati, OH
45215-6300 USA
PUCCI, PIERO Istituto di Chi_ica Organica e Biologica I Universita di Napoli
Via Mezzocannone, 16 80134 Napoli, ITALY
QUEMENER, V. Groupe Recherche en Therap.Anticancereuse Centre Hospitalier Universitaire
2, Ave. du Professeur Leon-Bernard 35043 Rennes Cedex, FRANCE
RICCIO, PIERLUIGI Dipartimento di Scienze Biochimiche Centro di Biologia Molecolare del CNR Universita di Ra.a "La Sapienza" 00185 Boma, ITALY
RISCOE, MICHAEL K.
Medical Research Service Veterans Administration Medical Center P.O. Box 1034
Portland, OR 97207 USA
768
RISTOW, JANET L. Department of Molecular Biology
and Biochemistry
University of California Irvine, CA 92717 USA
ROMANO, TERESA Istituto di Biochimica delle Macromolecole
I Facolta di Medicina, Universita di Napoli Via Costantinopoli, 16 80138 Napoli, ITALY
RUGGIERO, GIUSEPPE Dipartimento di Terapia Medica
I Facolta di Medicina Universita di Napoli 80134 Napoli, ITALY
RUSSO, GIAN LUIGI Istituto di Biochimica delle Macromolecole
I Facolta di Medicina, Universita di Napoli Via Costantinopoli, 16
80138 Napoli, ITALY
SACCHI, PIETRO
Dipartimento di Biochi.ica
Facolta di Medicina e Chirurgia Via Irnerio, 48
40126 Bologna, ITALY
SAKAI, YUKO Faculty of Pharmaceutical Sciences
Inohana Campus, Chiba University 1-8-1 Inohana Chiba City, 280 JAPAN
SCALABRINO, GIUSEPPE Istituto di Patologia Generale, Universita, Centro Ricerca in Patologia Cellulare, CNR Via Mangiagalli, 31 20133 Milano, ITALY
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Universita di Milano Via Mangiagalli, 31 20133 Milano, ITALY
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AcetylCoA:spermidine N8-Acetyltransferase (nSAT) ,
nuclear, 127-130, 137-140 AcetylCoA:spermidine/spermine N1-ace
tyltransferase (cSAT), cytosolic, 128, 137, 331-341 estrogenic control in rat uterus,
345-351 in uterus during estrous cycle,
347-348 Acetylpolyamines,
in human cancer cells, 331-344 in plants and fungi, 582-583
N1-Acetylspermidine, excretion, 135-138 in human cancer cells, 335-339 in human lymphocytes, 509-512 and polyamine degradation,130-138, in sea urchin embryos, 426
N1-Acetylspermine, and polyamine degradation, 130,
135, 138 Acetyltransferase (see AcetylCoA:
spermidine/spermine N1-acetyltransferase)
Acidothermophilic archaebacteria, AdoMet decarboxylase, 91-100 Wlusual polyamines, 633-642
Actin, 310 ADC (see Arginine decarboxylase) S-adenosyl 1,8-diamino-3-thiooctane
(AdoDAro) , effect on propylamine transferase,
119 S-adenosyl 1,12-diamino-3-thio-9-
azadodecane (AdoDATAD), effect on propylamine transferase,
119 S-adenosylmethionine decarboxylase
(AdoMet-DC) , androgen regulation of mRNA, 8-9 degradation, 267 in E. coli, 74-77, 83-85 effect on DNA methylation, 291-299 in gastrectamized rats, 370-375 half-life, 87-88
AdoMet-DC (cont'd.) inhibition by fluorinated analogs,
693-696 mechanistic properties, 85-87 mRNA, 266 proenzyme, 74, 77 properties in mammals, 101-109 pyruvoyl group generation, 82-85 regulation, 265 in SaccharomYces cerevisiae, 74-77 in Sulfolobus solfataricus, 91-100 structural properties, 83-85 substrate inactivation, 85-87 synthesis, 266 translational control, 244-245
Adenylate cyclase, regulation by polyamines, 535-543
AdoMet-DC (see S-adenosylmethionine decarboxylase )
African trypanosome, gr()\vth and transformation, 651-663 ODC in, 727-735
Agmatine, and DAD, 576-580
Agmatine ureohydrolase, of E. coli, 13-24
Aldehyde(s) , dehydrogenase, 152-153 formation, 152-153
AHA [see S- ( 5 '-deoxy-5 '-adenosy l)methyl thioethy lhydroxy lamine]
Amiloride, and polyamine uptake, 512-514
Amine metabolism, 147-161 Amine oxidase regulation,
biological fWlctions, 147-161 Aminoaldehyde(s), 152, 154 Aminoguanidine,
large bowel cancer promotor, 751 Androgen(s) ,
regulation of ODe, 1-11 Antimalarial drugs, 199 Antiprotozoal drugs, 202 Antitumor activity,
of fluorinated spermidine analogs, 691-706
771
Antitumor activity (cont'd.) of norspermidine, 707-716 of polyamine analogs, 687
Antizyme (see also OOC antizyme), acidic, 13-24 biochemical assay of, 37-38 eDNA, 32 immunological detection of, 38-41 inhibitor, 32-33 as modifier protein, 41 in mouse kidney, 25-35 mRNA, 33 specificity, 64-66 tissue distribution, 38-40
Apoptosis, and transglutaminase, 399
Archaebacteria, and AdoMet-OC, 91-100 and unusual polyamines, 633-642
Arginase, activity in resistant myeloma
cells, 253-254 Arginine decarboxylase (ADC),
estimation, 573-583 antizyme, 13-24 in trypanosomes, 727-735
Auxin, and somatic embryogenesis in
plants, 607-609
N1,N 8-bis-alkylspermidine, 130 N',N'-bis-Allenylputrescine,
and polyamine interconversion, 131, 137-140
N1,N 12 -bis(ethyl)homospermine (BEHSm) , and polyamine enzymes, 677-690
N1,N 8-bis(ethyl)spermidine (BES) , and polyamine enzymes, 677-690
Nl ,N12 -bis (ethyl) spermine (BESm) , and polyamine enzymes, 677-690
Bovine liver, MTA phosphorylase, 187-198
Brain tumors, 353-363 Breast cancer cells, 332, 335, 339
Cadaverine, anabasine biosynthesis and, 548 and DAO, 575
Calcium, binding to liposomes, 491-496 cycling, 491-496 and polyamine uptake in plants,
553-554 Caldopentamine,
in thermophiles, 633-642 Calmodulin, 241-252 Camostate,
and pancreatic growth, 379-387 Cancer promotion,
712
Cancer promotion (cont'd.) and DAO activity, 745-752 and SAO activity, 150
Carcinogenesis, and DAO activity, 747, 750-751
Casein kinase-2, and ODe phosphorylation, 46-48
Cations cycling, and spermine, 491-496
eDNA of OOC, 1-11 eDNA antizyme
from rat liver, 32 Celery cell culture,
embryogenesis and polyamines, 567-569
CHA (see Cyclohexy lamine) Chemotherapy,
of filarial infections, 737-743 Chirally deuterated substrate,
of propylamine transferase, 112 Cholecystokinin,
in pancreatic growth, 379-387 Crithidia fasciculata,
regulation of spermidine levels, 667-674
Cross-linking reactions of proteins, 391-395, 399
cSAT (see AcetyICoA:spermidine/spermine Nl-acetyltransferase)
Cyclohexylamine, effect on OOC activity, 29 effect on OOC-antizyme complex,
31-32 in plant cultures, 561-563
DAO (see Diamine oxidase) Decarboxylated S-adenosylmethionine
(dcSAM), 91-100, 128, 131 effect on DNA methylation, 291-294 metabolism, 101
Deoxyhypusine synthesis, 436-447, 449-458
Deoxyhypusine hydroxylase, 449-466 5'-Deoxy-5'-methylthioadenosine (see
Methylthioadenosine) S-(5'-deoxy-5'-adenosyl)-methylthio
ethylhydroxylamine (AMA), 102-104, 681-683, 686
5 '-Deoxy-5'-[N-methyl-N-[2-(aminooxy)ethyl]]aminoadenosine (MAOEA) , 102-104
5'-Deoxy-5'-[N-methyl-N-(3-hydrazinopropyl)]aminoadenosine (MHZPA) , 101-109
9-[5'-Deoxy-5'(methylthio)~-D-xylo-furanosyl]adenine, 219-228
Diacylglycerol, 481 -490 Diamine oxidase,
activity level, 147-161 in carcinogenesis, 745-752
Diamine oxidase (cont'd.) in fungi, 582-583 in human mucosa and polyps, 749-750 in large bowel cancer tissue,
748-749 in plants, 573-579 regulation, 155-156
1,3-Diaminopropane, in plants and fungi, 582-583
Diazabicyclononane, in plants, 573-587
Difluoromethylarginine (DFMA) , in cell cultures, 731-735 T. cruzi, 731-735 phytopathogens, 589-599 in plant cultures, 561-564
a-Difluoromethylornithine (DFMO), and acute infections of T.b.brucei,
655-659 and AdoMet-DC synthesis, 265-267 and cell differentiation, 291 in cell cultures, 261-272, 452-458 inactivation of ODC, 55-70 labeling of ODC, 55-70 on malaria parasites, 643-650 and pancreatic adaptation, 379-387 and phytopathogens, 589-599 in plants cultures, 561-564, and P. berghei, 722-723 and polyamine interconversion, 136-
139 in resistant human myeloma cell
line, 253-260 as trypanocidal agent, 667-674 and trypanosomiasis, 602-603,
727-735 6,6-Difluorospermidine, 691-706 7,7-Difluorospermidine, 691-706 2 ,4-Dinitrophenol ,
and polyamine uptake, 513-514 DFMA (see Difluoromethylarginine) DFMO (see Difluoromethy lorni thine) DNA methylation,
effect of dcAdoMet, 291-299 DNA methyltransferase,
from human placenta, 294-297 DNA/polyamine interactions, 517-524 DNA polymerases,
in malaria-infected erythrocytes, 643-650
DNA synthesis, in malaria-infected erythrocytes,
643-650 Doris verrucosa,
and MTA analog, 219-228
eIF-4D (see Eukaryotic initiation factor 4D)
Erythrocyte polyamine levels, in human neuro-oncology, 353-363
Erythrocyte poly. levels (cont' d. ) in malignant glioma patients,
353-363 17-~-Estradiol, 347 Estrogens,
and polyamine metabolism, 345, 356 Estrous cycle, 348 Ethionine,
and growth inhibitors, 205 Ethylene biosynthesis,
and polyamines in plants, 601-609 Ethylthioribose,
effects on protozoa, 203-204 mechanism of action, 204-205
Eukaryotic initiation factor 4D, 435-447, 449-458, 459-466
precursor, 435-447 Extreme thermophile,
and AdoMet-DC, 91-100 and unusual polyamines, 633-642
Fast atom bombardment mass spectrometry (FAB-MS), 403-409
Filarial worms, polyamine metabolism, 737-743
Fluorinated analogs of spermidine, biochemical and biological acti
vities, 691-706 (E)-2-(fluoromethyl)dehydroornithine,
inhibition of ODC, 692 5-Fluoromethylornithine,
and spermidine turnover, 131 Forskolin,
and adenylate cyclase activity, 535-543
Fungal growth inhibitors, 589-598 Fungi,
di- and polyamine oxidation, 582-583
Fusion of liposomes, 481-490
Giardia lamblia, and MTR kinase, 201 and MTR analog, 202
G-proteins, and ODC activation, 301-313
Gene, amplification, ODe, 253-255 expression, ODC, 1-11 expression, polyamine, 754 methylation, 258-260 transcription, ODC, 273-290
Genetic code, misreading of, 531
Genetic variation of ODC, 6-8 y-glutamyl,
putrescine, 393-395 spermidine, 393-395, 403-409 spermidine derivatives, 403-409 spermine, 393-395
773
y-glutamyl crosslinks, in epidermal cell envelopes,
417-420 y -glutamyl polyamines,
in cultured cells, 414-418 identification, 412-413 in mammalian tissues, 413-414 quantification, 412-413
Glutathionylspermidine, in trypanosomatids, 667-672
Glycolysis, effect of polyamine uptake,
512-514 Gramineae,
PADs in, 617-622 Growth,
of plants, and polyamines, 559-572 regulation of, in trypanosomatids,
667-672 regulation of polyamine biosynthe
sis, 241-252 GTP analogs,
and adenylate eye late activity, 535-543
Guanine nucleotide binding proteins, 535-543
Guazatine, fungicide, 582 and hypusine biosynthesis, 454
Heart cell cultures, and adenylate cyclase activity
regulation, 535-543 (2R,5R)-6-Heptyne-2,5-diamine (MAP),
inhibition of polyamine biosynthesis, 696-702
Hexamethylenebisacetamide, effects on murine splenic
lymphocytes, 427, 432 Histidine decarboxylase, 81-89 HMBA (see Hexamethylenebisacetamide) HTC cells, 55-70, 691-706 Human cancer cells,
and polyamine recycling enzymes, 331-344
Human liver MfA phosphorylase, 211-217
Human mucosa DAD activity, 749-750 Human placenta KI'A phosphorylase,
165-178 Human serum MfA, 229-238 Hydrogen peroxide,
metabolic effects, 154 Hypusine,
biosynthesis, 435-447, 449-458, 459-466
in cultured cells, 414-418
Inositol, 301-313
774
Interconversion of polyamines, 127-145
Intestinal adaptation, 379 Intestinal mucosal hyperprolife
ration, and DAD activity, 745-752
Lactate formation, 513-515 Large bowel tumor,
promotion by DAO inhibition, 745-752
Leishmania donovani, 211-217 Leukemia, 179, 258-260 Liposomes,
and polyamines, 469-480, 481-490 Lymphocyte mitogenesis, 301-313 Lysine decarboxylase, 548-557
Macrophage, activation by TGase, 398
Malaria, DFMO effects, 643-650 DNA synthesis in malaria-infected
erythrocytes, 643-650 and polyamine analogs, 717-726 and MTR kinase, 199-210
Mamnary gland, antizyme in, 38-40
MAO (see Monoamine oxidase) Membrane,
interaction with polyamines, 481-490
Messenger RNA (mRNA) , of ODC, 1-11, 18, 241-252, 262-265
Methionine, recycling pathway, 200
Methylglyoxal-bis(guanylhydrazone), (MGBG) ,
and AdoMet-DC regulation, 101-109, in plant cultures, 562-564 in polyamine recycling enzymes,
337-341 and transport of spermine across
membrane, 491-496 S-methyl-5'-(methylthio)adenosine,
(see Methylthioadenosine) Methylthioribose (MTR),
analogs, effects on protozoa, 199-210
kinase, and antiprotozoal drugs, 99-210 in protozoa, 199-210
Methylthioadenosine (MfA), analog, 219-228 in Doris verrucosa, 219-224 effect on AdoMet metabolism, 182 effect on diphtamide synthesis, 182 effect on polyamine metabolism, 181 metabolism, 756 in protozoa, 200-201
MTA (cont'd.) toxicity, 183-184
MTA nucleosidase, in protozoa, 201-202
MTA phosphorylase, antisera, 187-198 in bovine liver, 187-198 deficiency, 179-185 in Doris verrucosa, 223 in human placenta, 165-178 in human serum, 229-238 kinetics of, 165-178 as marker in acute hepatitis,
229-236 physico-chemical and immunological
properties, 187-198 in protozoa, 211-217 substrate specificity, 165-178
MI'R ( see Methyl thioribose) Methylthioxylofuranosyl adenosine,
219-228 t-GBG (see Methylglyoxal-bis(guanyl
hydrazone) Mitochondrial proteins,
transport, 497-508 Molecular modeling,
polyamine DNA interactions, 517-521
Monoamine oxidase, activity, 151-152 tissue distribution, 148
Monofluoromethyl agmatine (FMAG), effect on trypanosomes, 731-733
Monofluoromethyldehydroarginine (.1-MFMA) ,
effect on trypanosomes, 731-735 6-Monofluorospermidine,
inhibition of ODe, 691-706 6-Monofluorospermine,
inhibition of one, 691-706 7-Monofluorospermidine,
inhibition of ODe, 691-706 Morris hepatoma, 700-703 mRNA (see Messenger RNA) MTA (see Methylthioadenosine) Mucosal hyperproliferation,
and DAD activity, 750-751
Nematodes, polyamine metabolism, 737-743
Neurospora eras sa , polyamines and one activity,
627-632 Norspermidine (Nspd) ,
antitumor activity, 707-716 nSAT (see AcetylCoA:spermidine N8_
acetyltransferase),
ODe (see Ornithine decarboxylase)
OCT (see Ornithine carbamoyltransferase)
o. malhamensis, and MI'R analogs, 202
Oncogene transfection, and polyamine analogs, 686-687
Ornithine carbamoyltransferase precursor,
transport, 497-508 Ornithine decarboxylase,
activation during lymphocyte mitogenesis, 301-313
activity in spinal cord, 365-378 androgen regulation, 1-11 and casein kinase 2, 46-48 control in N. crassa, 628-630 decay rate, 25-35 degradation, 261-271 erythroleukemia cells, 48-50 in fungi and higher plants,
589-599 gene amplification, 253-257 growth control, 242-244 in HTC cells, 57 human gene methylation, 258-260
in leukemia, 258-259 human gene structure, 253-257 in human myeloma cells, 253-260 induction by TPA, 273-290 modifications, 55-70 mRNA, 1-11, 18, 241-252, 262-265, multiple forms, 55-70 and norspermidine, 709 in pancreatic adaptation, 379-387 phosphorylation, 45-53, 55-70 and polyamine metabolic cycle,
128-136 post-transcriptional stabilization,
243 in rat heart, 45 regulation, 261, 45-53
inhibition by fluorinated polyamine analogs, 691-706
SH groups, 49-51 spermidine-induced modifications,
69-70 stabilization, 25-35 synthesis, 262-265 and thioredoxin, 43 transcription, 243 translational control, 245 in trypanosomes, 717-735
one antizyme (see also Antizyme), 13-24, 25-35, 38-41, 55-66
Ornithine:2-oxoacid aminotransferase (OAT) ,
and polyamine metabolic cycle, 128, 131
Ouabain, and polyamine uptake, 512-514
Oxidized polyamines, 147-161
775
Pancreas, antizyme in, 38-41
Pancreatic adaptation, role of ODC in, 379-387
Parasitic diseases, and MTR analog, 199-210
Pernicious anemia (PA) , 365-378 Phosphatase,
and ODC activity, 55-70 Phosphatidylethanolamine,
interaction with polyamines, 481-490
Phosphatidylcholine, 481-490 Phosphatidylinositol,481-490 Phosphatidylserine, 481-490 Phosphatidic acid, 481-490 Phospholipids,
and protein kinase C, 469-480, interaction with polyamines,
481-490 Phosphorylation,
of ODC,45-53, 55-70 of proteins and polyamines,
469-480, Phytopathogen,
polyamine biosynthesis inhibition, 589-598
PKC (see Protein kinase C) Plants,
cell cultures, 559-572 diamine oxidase, 573-580 DFMA effects, 561-563 embryogenesis, 567-569 ethylene biosynthesis, 601-609 growth and polyamines,547, 558,
559-572, hormones, 559-564 nitrogen nutrition, 561-564 pathogenes and polyamine biosyn-
thesis inhibitors, 590-598 polyamine distribution, 551-553 polyamine oxidases, 582-583 and polyamine uptake, 548-557 salt stress, 565-566
Plasmodium berghei, growth inhibition by polyamine
analogs, 722-723 and MTR analogs, 199-210
Plasmodium falciparum, cell cycle and polyamines, 643-650 cultures; polyamine analog effects,
717-726 drug-resistant, 199-210 growth inhibition by polyamine
analogs, 719-721 Polyamines,
catabolism, 127, 134, 138 in cell cycle of malaria parasite,
643-650 conjugates, 393-395, 403-409, 411-
776
Polyamines (cont'd.) 422, 755
cross-linking in epidermal cell envelopes, 417-420
in erythrocytes of glioma patients, 353-363
and ethylene biosynthesis in plants, 601-609
excretion, 137-138 in filarial worms, 737-743
fluorinated analogs, 691-706 in growth and differentiation of
plant cells, 559-572 in human cancer cells,131-140 in human neuro-oncology, 353-363 in hypusine biosynthesis, 435-447,
449-458 -induced protein, of E. coli,
315-320 jnhibitors, 677-690, 754-755 in malignant glioma patients,
353-363 in Neurospora crassa, 630-631 and somatic embryogenesis in
plants, 567-569, 602-607 and transport of proteins into
mitchondria, 497-508 in trypanosomes, 651-663, 727-735 turnover, 132, 134-137
Polyamine acetylation, 127-145, 331-340,
Polyamine analogs, and DNA interactions, 517-521 and regulation of polyamine
biosynthesis, 677-690 effects on malaria parasites,
717-725 Polyamine binding,
to liposomes, 481-490 to nucleic acids, 517-524 to phospholipids, 481-490, 525-533 to plant cell surface, 547-558 to plant cell walls, 547-558
Polyamine biosynthesis, post-translational control in
E. coli, 13-24 regulation in mammalian cells, 261-
271 regulation in biosynthetic enzymes,
677-690 inhibitors and plant pathogenesis,
590-598 Polyamine biosynthetic decarboxylases
(PBD) , 365, 378 Polyamine effects,
on adenylate cyclase activity, 535-543
on globin synthesis, 323-326 on malarial DNA synthesis, 643-650 on membrane fusion, 481-490
Polyamine effects (cont'd.) on protein kinase C, 469-480,
481-490 on protein synthesis, 315-330 on ribosomal protein S1, 315-320 on thymidine kinase, 320-323
Polyamine interconversion pathway, 127-145, 346-347
Polyamine metabolism, 147-161, 331, 340
in filarial worms, 737-743 in trypanosomes, 727-731
Polyamine oxidase, biological functions, 148 in filarial worms, 741 in fungi, 582-583 inhibition, 135-136, 140 from maize seedlings, 617, 622 PAO, 128, 135-140 in plants, 550-582 and polyamine interconversion, 128,
135, 138-140 tissue distribution, 148
Polyamine transport, 132, 134-135 in cultured plant cells, 548-553 in filarial worms, 740 in human lymphocytes, 423-426, 509-
515 in isolated protoplast and
vacuoles, 554-557 in sea urchin embryos, 423-426
Polynucleotides, binding of divalent cations, 528
Polypeptide synthesis, messenger-free, 532
Polyphosphoinositides, 481-490 Polyps,
DAO activity in, 749-750 Polysomes,
and ODC mRNA, 245 Post-translational control,
of polyamine biosynthesis in E. coli, 13-24
Post-translational modification, of eIF-4D, 435-447, 459-466 of proteins by polyamines, 391-395 of proteins,
and sea urchin embryos, 428 Post-transcriptional stabilization,
241-252 Pregnancy,
and SAO activity, 147-161 Proenzyme, 74-77
of AdoMet decarboxylase, 105-107 Programmed cell death (see Apoptosis) Promyelocytic leukemia,
and TGase, 395 2-Propenal, 81-89 Propylamine transferase,
genes, 253-260
Propylamine transferase (cont'd.) structures, 253-260
Protein kinase C, activation, 243, 273-290, 469-480,
481-490 Protein-polyamine conjugates, 393-395 Protein synthesis,
polyamine effect on, 313-320, 633-642,
in trypanosomes, 727-735 Protein transport, 497-508 Protozoa,
MTA phosphorylase in, 211-217 Purine analogs, 212, 215-216 Purine nucleoside analogs, 212-215 Putrescine,
in cell differentiation, 291-299 effect on AdoMet-DC synthesis, 103 oxidation in fungi, 582-583, oxidation in plants, 573-582 uptake in plants, 547-558
Putrescine aminopropyltransferase, 111-116
Putrescine N-acetyltransferase, 738-739
Pyrroline, and DAO, 573-582
Pyrroloquinoline quinone (PQQ), and DAO, 574-475
Pyridoxal phosphate, and DAO, 576
Pyruvate, in AdoMet-DC,73-79, 101-109 mechanism of generation in SAMDC,
82, 85
Rat hepatoma, and fluorinated polyamines, 691-706
Rat kidney ODC, 4 Rat pancreas, 379-387 Rat seminal vesicle protein IV
(SV-IV), 403-409 Rat uterus,
estrogenic control of SAT activity in, 345-351
Retinoic acid, effect on tissue TGase, 397-399
Retinoid, and tissue TGase, 398-399
Ribosomal proteins, and ODC antizyme, 13-24
Ribosomal protein Sl, polyamine effect on, 315-320
Ribosomes, binding of tRNA, 529, 537
S-180 cells, 211-213 SAM-DC (see S-Adenosyl-L-methionine
decarboxylase) SAO (see Serum amine oxidase)
717
SAR (see Spennidine/spennine NL acetyltransferase)
SAT (see AcetylCoA:spennidine/ spennine N1-acetyltrasferase)
Sea urchin embryos, 423-434 Seminal vesicle protein IV (SV-IV),
403-409 Senescence,
and transglutaminase, 399 Serum amine oxidase (SAO),
biological functions, 147-161 Signet-ring cell carcinoma, 747 Sim-nor-spennidine, 92-94 Sin-nor-spennine, 92-94 Somatic embryogenesis,
of plants, and polyamines, 567-569, 602-607
spe2, and AdoMet-DC expression, 76-77
speD, gene and spennidine synthase, 76
speE, gene and AdoMet-DC, 74
Spermidine, acetyl transferase , 335-339 analogs, 677-690, 691-706 in cell differentiation, 291-300 effect on AdoMet-DC content, 104 effect on AdoMet-DC expression, 76 effect on OCT transport into mito-
chondria, 497-508 in erythrocytes, 353-363 in hypusine biosynthesis, 435-447,
449-458 -induced modification of ODC,
63-70 levels in trypanosomatids, 670 oxidation in fungi, 582-583 oxidation in plants, 580-582 uptake,
in plant protoplasts, 554-557 Spennidine synthase, 119-126
antibody production, 119-122 mechanism of reaction, 111-117 purification and properties from
mammals, 117-122 Spennine,
analogs, 677-690, 691-706, effect on adenylate cyclase,
535-543 effect on AdoMet-DC synthesis,
101-109 effect on protein kinase C binding
to liposomes, 469-480 effect on calcium binding to lipo
somes, 481-490 effect on OCT transport into mito
chondria, 497-508 effect of polyamine metabolism of
filarial worms, 737-743
778
Spennine (cont'd.) effect on tRNA, 525-533 effect on tRNA-ribosome interac-
tions, 525-533 efflux, 491-496 in erythrocytes, 353-363 influx, 491-496 in human cancer cells, 331-344 oxidation in plants, 573-587
Spennine synthase, antibody production, 119-133 inhibition, 691-706 inhibition by fluorinated
spennidine analogs, 696-698 purification and structure, 117-126 transport, 481-490
6-Spennyne, effect on polyamine biosynthetic
enzymes, 677-690 Spongifonn degeneration, 365-378 Steroid hormone action, 1-11 Subacute combined degeneration (Sen),
365-378 Sulfolobus acidocaldarius,
and unusual polyamines, 633-642 Sulfolobus solfataricus,
AdoMet-DC, 91-100 SV-IV (see Seminal vesicle protein IV)
Teratocarcinoma stem cell, differentiation, 291, 296
Testosterone, and ODC, 1-11
12-0-Tetradecanoylphorbol-13-acetate (TPA) , 273-290
Tetrakis(3-aminopropyl)ammonium, in thennophiles, 633-642
Thennine, in thermophiles, 633-642
Thennophilic enzymes, 91-100 Thennus thermophilus, in thermophiles, 633-642 Thioredoxin,
and ODC, 49 Thymidine kinase,
polyamine effect on, 320-333 Tissue transglutaminase,
activity in mouse, 396-397 Tin of DNA,
and polyamines, 633-642 Tobacco cell culture,
and inhibition of polayamine biosynthesis, 561-566
TPA (see 12-0-Tetradecanoylphorbol-13-acetate)
Transfer RNA (tRNA), aminoacylation of, 528 binding of spennine and divalent
cations to, 528
tRNA (cont' d. ) conformation, stabilization by
spermine, 525-528 ribosome binding, 529-530
Transglutaminase ('mase) , in rat seminal vesicles, 403-409 in Chinese hamster ovary cells
(CHO), 396-397 and growth and differentiation,
398-399 in human epidermal cell envelopes,
417-420 and polyamines, 391-401, 756
Transport, of ODC precursor, 497-508 of polyamines, 677-690
in human lymphocytes, 423-426, 509-515
in plants, 547-558 Tris(3-aminopropyl)amine,
in thermophiles, 633-642 Trypanosoma b. brucei, 211-217,
653-663 and DFMA treatment, 728-731
Trypanosoma cruzi, 211-217, and DFMA treatment, 728-731
Trypanosomes, and ODC activity, 727-735 and trypanothione, 667-672
Trypanosomiasis, effect of DFMO, 653-663
Trypanothione, regulator of spermidine levels in
trypanosomes, 667-672 Trypsin inhibitor, 379-387, 755 Tumor induction, 745-752 TlmIor promoter,
and ODC induction, 273-290 Turnover,
of ODC, 45-53
Uptake, of polyamines,
by human lymphocytes, 423-426, 509-515
by sea urchin embryos, 423-424, 426
Vanadate, and polyamine uptake, 512-514
Xylosyl-MTA (see 9-[5'-Deoxy-5' (methylthio)a-D-xylofuranosyl]adenine)
lea mays, PADs in, 617-622
779