bacteria just can’t resist

33 Broad spectrum - Amoxicillin has a broader spectrum and

has faster action than other penicillins - Is active against almost all bacteria

except Mycoplasma33 Proficient tissue distribution

- Good tissue distribution in lungs and muscles - Highest concentrations are found in kidney,

liver and the gastro-intestinal tract33 Fast resorption

- Amoxicillin is resorbed better than ampicillin - High serum levels are obtained rapidly

AMOXYVETo-50 S soluble powderContains per gram powder: 573 mg amoxicilin trihydrate soluble powder equivalent to 500 mg amoxicillin

IndicationsInfections caused by micro-organisms susceptible to amoxicillin in calves, poultry and pigs, particularly:• Poultry:

- Coryza: Avibacterium paragallinarum (Haemophilus paragallinarum)

- Dysbacteriosis - Enteritis: Clostridiaceae spp. - Colibacillosis: E. coli - Enterococcus spp. - Ornithobacterium rhinotracheale (ORT) - Erysipelothrix rhusiopathiae - Fowl Cholera: Pasteurella multocida

• Calves, lambs: - Trauma and peri-operation treatment:

Escherichia coli, Klebsiella spp., Staphylococcus spp., Trueperella pyogenes and other Gram-negative anaerobes (Bacteroides spp., Fusobacterium necrophorum, Prevotella)

- Respiratory tract infections: Pasteurella multocida, Mannheimia haemolytica, Histophilus somni, Trueperella pyogenes

- Necrobacillosis: Fusobacterium necrophorum - Gastrointestinal tract infections: Escherichia coli,

Salmonella spp. (Typhimurium/Dublin), Clostridium - (Endo-)Metritis: Trueperella pyogenes, coliforms,

Gram-negative anaerobes - Peritonitis: mixed infection with anaerobes,

Escherichia coli, Pasteurella spp.• Pigs:

- Exsudative epidermitis: Staphylococcus hyicus - Trauma - Respiratory tract infections:

• Atrophic rhinitis - Pasteurella multocida, Bordetella bronchiseptica

• Bronchopneumonia - Pasteurella multocida • Pleuropneumonia - Actinobacillus

pleuropneumoniae • Gastrointestinal tract infections: Clostridium

perfringens - Arthritis: Streptococcs - Urogenital tract infections: coliforms - Meningoencephalitis: Streptococcus suis - Polyserositis: Haemophilus parasuis - Erysipelothrix rhusiopathiae

Contra-indicationsKnown hypersensitivity to penicillins.

Pharmacodynamic propertiesAmoxicillin, a semi-synthetic penicillin, is an acid-resistant broad-spectrum antibiotic with bactericidal action, active against a wide variety of infectious pathogens. Amoxicillin inhibits in sensitive strains the cell wall synthesis. Many Gram-negative and Gram-positive bacteria are sensitive (MIC-values < 0.25 μg/ml). Moderately sensitive (MIC 0.25-5 μg/ml) are Streptococcus faecalis, Salmonella spp. and E.coli. Development of resistance is mainly due to the production of penicillinase (beta lactamase). Development of resistance occurs slowly and stepwise as is the case for most penicillins. Because of its mode of action amoxicillin is not active against mycoplasms (Mycoplasma is a genus of bacteria that lack a cell wall).

Pharmacokinetic propertiesFollowing oral administration amoxicillin is resorbed better than ampicillin resulting in higher concentrations in blood and urine. The highest concentrations (several times higher than in the serum) are found in the urine (kidneys) and bile (liver). Maximum plasma concentrations are reached after 2.5 hours. The product is well distributed in most tissues (lungs and muscles). Amoxicilin is mainly excreted via the kidneys, a smaller portion is also excreted via the liver with bile and faeces.

Side-effectsHypersensitivity reactions can occur, varying from mild skin reactions to anaphylaxis.

Special precautions for useSimultaneous treatment with fast acting bacteriostatic products should be avoided. Direct contact with skin and inhalation of the powder should be avoided. Amoxicillin is destroyed by granulation due to the heat. Use with precaution when treating Salmonella in pigs and poultry.

InteractionsAntagonism of amoxicillin and fast acting bacteriostatic products such as chloramphenicol and tetracyclines.

OverdosingAmoxicillin trihydrate has an excellent therapeutic index. With the normal dosages there is no risk of overdosing.

StorageStore dry, in a well-closed packing, below +25°C and protected from light.

Dosage and administrationFor oral administration via drinking water, feed or milk-re-placer. AMOXYVETo-50 S is highly soluble at every pH no matter the hardness of the water. Presolutions in very hard water can show a little precipitation. This is calcium carbonate (CaCO3 ) and this does not affect the solubility or the efficiency of AMOXYVETo-50 S.Poultry:The general dose is 10 mg amoxicillin per kg body weight per day. 10 g AMOXYVETo-50 S per 100 litres of drinking water or 20 g AMOXYVETo-50 S per 100 kg feed, during 3 to 5 consecutive days. Double doses if necessary.Medicated water (< 25° C) should be refreshed every 12 hours. Medicated milk should be consumed immediately. Pigs, calves:The general dose is 20 - 40 mg amoxicillin per kg body weight, given in two administrations (e.g. 1 - 2 g AMOXYVETo-50 S per 50 kg body weight, twice daily), 37.5 - 75 g AMOXYVETo-50 S per 100 litres of drinking water or 75 - 150 g AMOXYVETo-50 S per 100 kg feed, during 3 to 5 consecutive days.

Presentation100 g jars; 80 jars per carton1 kg jars; 10 jars per carton

V.M.D. nv/sa, member of Inovet • Hoge Mauw 900 • 2370 Arendonk • Belgium Tel +32 14 67 20 51 • Fax +32 14 67 21 52 • info@inovet.eu • www.inovet.eu • join us on

04/2018 ZPM-AMOXI-03-FOL-XXX-EN.00 / All rights reserved. No part of this brochure may be reproduced, stored in a database or retrieval system, or published, in any form or in any way, electronically, mechanically, by print, photocopy, microfilm or any other means without prior written permission from V.M.D. n.v./s.a. Customers/users are required to check the patent laws in their respective markets prior to entering into agreement with us. No liability will be accepted by us in case of non-compliance. V.M.D. n.v./s.a. reserves the right to change the specifications of its products without prior notice.

AMOXYVETo-50 S soluble powderContains per gram powder: 573 mg amoxicilin trihydrate soluble powder equivalent to 500 mg amoxicillin