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drug study
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Generic Name: Amlodopine
Brand Name: Norvasc
Classifications: cardiovascular
agent; calcium channel blocker
Pregnancy Category:C
Availability 2.5 mg, 5 mg, 10 mg
tablets
Actions
Amlodipine is a calcium channel
blocking agent that selectively blocks
calcium ion reflux across cell
membranes of cardiac and
vascular smooth musclewithout
changing serum calcium
concentrations. It predominantly acts
on the peripheral circulation,
decreasing peripheral vascular
resistance, and increases cardiac
output.
Therapeutic effects
Amlodipine reduces systolic,
diastolic, and mean arterial blood
pressure.
Uses
Treatment of mild to moderate
hypertension and angina.
Contraindicatons
Hypersensitivity to amlodipine.
Route & Dosage
Hypertension
adult:PO 5–10 mg once daily
geriatric:start with 2.5 mg, adjust
dose at intervals of not less than 2 wk
Renal Impairment
Start with 2.5 mg, adjust dose at
intervals of not less than 2 wk
Administration
Oral
Give drug without regard to meals.
Prescribed initial dosages of 2.5 mg
daily are common if added to a
regimen including other
antihypertensive drugs.Note: Doses
are usually titrated over a period of
14 d or more rapidly if warranted.
Store at 15°–30° C (59°–86° F).
Adverse effects
CV:Palpitations, flushing tachycardia
, peripheral or facial edema,
bradycardia, chest pain, syncope,
postural hypotension.
CNS:Light-headedness, fatigue,
headache.
GI:Abdominal pain, nausea,
anorexia, constipation, dyspepsia,
dysphagia, diarrhea, flatulence,
vomiting.
Urogenital:Sexual dysfunction,
frequency, nocturia.
Respiratory:Dyspnea.
Skin:Flushing, rash.
other:Arthralgia, cramps, myalgia.
Nursing Implications
Assessment & Drug Effects
Monitor BP for therapeutic
effectiveness. BP reduction
is greatest after peak
levels of amlodipine are
achieved 6–9 h following
oral doses.Monitor for S&S
of dose-related peripheral
or facial edema that may
not be accompanied by
weight gain; rarely, severe
edema may cause
discontinuation of drug.
Monitor BP with postural
changes. Report postural
hypotension. Monitor more
frequently when additional
antihypertensives or
diuretics are added.
Monitor heart rate; dose-
related palpitations (more
common in women) may
occur.
Patient & Family Education
Report significant swelling
of face or extremities.
Take care to have support
when standing & walking
due to possible dose-
related
light-headedness/dizziness.
Report shortness of breath,
palpitations, irregular
heartbeat, nausea, or
constipation to physician.
Do not breast feed while
taking this drug without
consulting physician.