DRUG NAME CLASSIFICATION INDICATIONS CONTRAINDICATION S ROUTE & DOSAGE DRUG ACTION ADVERSE EFFECTS Generic name: Amlodipine Besylate Brand name: Norvasc Amvasc Cardiovascular agent Calcium channel blocker Antihypertensive agent Hypertension Coronary Artery Disease (CAD) Chronic Stable Angina Vasospastic Angina (Prinzmetal' s or Variant Angina) Angiographic ally Documented CAD Patients with known sensitivity to amlodipine Pregnancy Lactation PO: The usual initial antihypertensive oral dose of Norvasc is 5 mg once daily with a maximum dose of 10 mg once daily. Small, fragile, or elderly patients, or patients with hepatic insufficiency may be started on 2.5 mg once daily and this dose may be used when adding Norvasc to other antihypertensive therapy. The recommended dose for chronic stable or vasospastic angina is 5- 10 mg, with the lower dose suggested in the elderly and in patients with hepatic insufficiency. Most patients will require 10 mg for adequate effect. The recommended dose range for patients with coronary artery disease is 5-10 mg once daily. In clinical studies, the majority of patients required 10 mg. The effective antihypertensive oral Calcium channel blockers block the transport of calcium into the smooth muscle cells lining the coronary arteries and other arteries of the body. Since calcium is important in muscle contraction, blocking calcium transport relaxes artery muscles and dilates coronary arteries and other arteries of the body. By relaxing coronary arteries, amlodipine is useful in preventing chest pain (angina) resulting from coronary artery spasm. Relaxing the muscles lining the arteries of the rest of the body lowers the blood pressure, which reduces the burden on the heart as it pumps blood to the body. Reducing heart burden lessens the heart muscle's Side effects of amlodipine are generally mild and reversible. The two most common side effects are headache and edema (swelling) of the lower extremities. Less common side effects include dizziness, flushing, fatigue, nausea, and palpitations.

Amlodipine Besylate drug study

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DRUG NAME CLASSIFICATION INDICATIONS CONTRAINDICATIONS ROUTE & DOSAGE DRUG ACTION ADVERSE EFFECTSGeneric name:

Amlodipine Besylate

Brand name:

NorvascAmvasc

Cardiovascular agent

Calcium channel blocker

Antihypertensive agent

Hypertension

Coronary Artery Disease (CAD)

Chronic Stable Angina

Vasospastic Angina (Prinzmetal's or Variant Angina)

Angiographically Documented CAD

Patients with known sensitivity to amlodipine

Pregnancy

Lactation

PO: The usual initial antihypertensive oral dose of Norvasc is 5 mg once daily with a maximum dose of 10 mg once daily.Small, fragile, or elderly patients, or patients with hepatic insufficiency may be started on 2.5 mg once daily and this dose may be used when adding Norvasc to other antihypertensive therapy.The recommended dose for chronic stable or vasospastic angina is 5-10 mg, with the lower dose suggested in the elderly and in patients with hepatic insufficiency. Most patients will require 10 mg for adequate effect.The recommended dose range for patients with coronary artery disease is 5-10 mg once daily. In clinical studies, the majority of patients required 10 mg.The effective antihypertensive oral dose in pediatric patients (6-17 years) is 2.5 mg to 5 mg once daily.

Calcium channel blockers block the transport of calcium into the smooth muscle cells lining the coronary arteries and other arteries of the body. Since calcium is important in muscle contraction, blocking calcium transport relaxes artery muscles and dilates coronary arteries and other arteries of the body. By relaxing coronary arteries, amlodipine is useful in preventing chest pain (angina) resulting from coronary artery spasm. Relaxing the muscles lining the arteries of the rest of the body lowers the blood pressure, which reduces the burden on the heart as it pumps blood to the body. Reducing heart burden lessens the heart muscle's demand for oxygen, and further helps to prevent angina in patients with coronary artery disease.

Side effects of amlodipine are generally mild and reversible. The two most common side effects are headache and edema (swelling) of the lower extremities. Less common side effects include dizziness, flushing, fatigue, nausea, and palpitations.

NURSING CONSIDERATIONS

AssessmentMonitor BP for therapeutic effectiveness. BP reduction is greatest after peak levels of amlodipine are achieved 6–9 h following oral doses.Monitor for S&S of dose-related peripheral or facial edema that may not be accompanied by weight gain; rarely, severe edema may cause discontinuation of drug.Monitor BP with postural changes. Report postural hypotension. Monitor more frequently when additional antihypertensives or diuretics are added.Monitor heart rate; dose-related palpitations (more common in women) may occur.

Patient & Family EducationReport significant swelling of face or extremities.Take care to have support when standing & walking due to possible dose-related light-headedness/dizziness.Report shortness of breath, palpitations, irregular heartbeat, nausea, or constipation to physician.Do not breast feed while taking this drug without consulting physician.