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www.amirqureshi.co.uk Limb Reconstruction Amir Qureshi Consultant University Hospital Southampton

Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

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Page 1: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

www.amirqureshi.co.uk

Limb ReconstructionAmir Qureshi

ConsultantUniversity Hospital

Southampton

Page 2: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

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What is Limb Reconstruction Surgery?

❖ Recognised Orthopaedic Sub-speciality

❖ Specific clinical orthopaedic problems

❖ Team (surgeon, theatre staff, nurses and physio’s)

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Tools of the trade

❖ traditionally associated with external fixators

❖ however internal fixation devices may also be utilised

Page 4: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

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Why an external fixator?

❖ If you cannot cover the wound with soft tissue at the end of the procedure

❖ If you cannot get the ends of the bone together e.g. if bone is missing

❖ If correcting a deformity acutely will risk neurovascular or soft tissue.

❖ to preserve length whilst correcting deformity

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a bit about fracture healing

Page 6: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

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A bit about fracture healing

✤ Physiological process

✤ replaces injured bone

✤ restores biological/mechanical properties

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01

Trauma

Disruption of

✤ stability

✤ vascular supply

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Angiogenesis

↑movement at fracture gap = tearing of newly formed vessels = ↓ cap formation

Page 9: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

Mechanical Environment

Page 10: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

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Mechanical Environment

✤ local forces critical to bone regeneration and healing

✤ Wolff law: remodelling in response to stress & strain

Page 11: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

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Strain (movement) influences:

✤ cellular response

✤ formation of capillaries

✤ resultant tissue formed at # site

Page 12: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

✤ increased strain affects ability to form capillaries, and hence bone (has high oxygen requirement)

✤ gross instability leads to fibrocartlilage formation

✤ increased stability increases vascularity and bone formation

Page 13: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

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No Strain with anatomical reduction is GOOD

No Strain with poor reduction is BAD

Controlled Strain with adequate reduction is GOOD

Excessive Strain beyond limit of healing tissue is BAD

Degree of strain during treatment determines tissue response / type of healing

Page 14: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

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Bone Loading

✤ promotes flow through 3-D canaliculi network populated by osteocytes

✤ pulsating fluid releases cell signalling molecules from osteocytes

✤ forms callus

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Secondary Fracture Healing

Page 16: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

key concept.....

✤ Primary Bone Healing – occurs when there has been anatomical reduction and interfragmentary compression of all fracture fragments ( no motion between fracture surfaces under functional load)

✤ Secondary (Callus) Bone Healing – occurs when there is a controlled degree of motion between fracture fragments, but always lower than the strain limit

Page 17: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

1. Haematoma formation & inflammation

2. Soft callus formation

3. Hard callus formation

4. Remodelling

Phases of Bone Healing

Page 18: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

2. SOFT CALLUS – formation of fibrous tissue, cartilage, woven (immature bone)increased strain at centre of fracture gap, new vessels can’t form, low oxygen tension.Cartilage formed as has low oxygen requirement

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hard callus phase

✤ cutting cones. remove callus and lay down new bone

Page 20: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

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REMODELLING

woven bone remodelled to lamellar bone, medullary canal reforms.

Page 21: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

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✤ a frame provides relative stability (controlled strain)

✤ this controlled movement allows callus to bridge the fracture gap

✤ once the callus is strong it will be gradually replaced by bone

✤ we can gradually ‘stretch’ new forming bone (regenerate) to fill in a gap (bone transport) or make new bone (limb lengthening)

Summary

Page 22: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

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clinical applications

Page 23: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

Acute Fractures not amenable to routine surgery

Page 24: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

Non Unions

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Infection

• difficulttoeradicate• surgicaltreatmentaswellas

medical• Bacterialiedormantin

sequestratedareas• colonisationofinternalfixation• Internalfixationcanfail• Externalfixationprovides

stability• Boneexcision/lengtheningoften

required

Page 26: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

Bony angular deformities

Page 27: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

Leg length discrepancy – congenital or from injury

Page 28: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

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Types of frames

❖ Monolateral (eg Hoffman)

❖ damage control surgery

❖ Circular

❖ classical Ilizarov type frame

❖ Hexapod

❖ TSF/ Orthofix TL Hex

Page 29: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

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Monolateral

Page 30: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

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Circular

Page 31: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

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Hexapod

Page 32: Amir Qureshi Limb Reconstruction · 2018. 5. 2. · restores biological/mechanical properties . 01 ... Angiogenesis ↑movement at fracture gap = tearing of newly formed vessels =

Patients…

✤ Patients are up walking within 48 hours

✤ As there is no ‘rattle’ or strut movement, they have confidence in hardware

✤ Similarly physio’s are confident in pushing mobilisation

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