Upload
others
View
10
Download
3
Embed Size (px)
Citation preview
AMI Construction in Lower Extremity
Amputees: Clinical Outcomes to DateMatthew J. Carty, MD
Staff Surgeon, Division of Plastic Surgery
Brigham and Women’s Hospital
Associate Professor of Surgery
Harvard Medical School
I have no disclosures or conflicts of interest.
BWH
USNMCSD
Matthew CartySimon TalbotEric BlumanGeorge DyerAnthony AmatoStacy SmithLuis BeltranSarah WelchKendall ClitesLori Berger
Craig Salt
MIT
WRNMMC
UCSF
UMich
NWUMC
Hugh HerrShriya SrinivasanRickard Branemark
Jason SouzaKyle PotterJonathan Forsberg
Richard O’Donnell
Paul CedernaTyler Clites
Greg Dumanian
Funding support via Stepping Strong Innovator Fund, DoD/PRORP, DARPA
Acknowledgments
AMI Architecture Models
“Native”“Regenerativ
e”
8
Patient Summary to Date
Total Patients
Gender Split (M,F)
Age (Years)
BMI
ALOS (Days)
Operative Time (Min)
• 16 BKA, 3 AKA
• 47% Male, 53% Female
• 40.1
• 26.4
• 5.4 BKA, 9.7 AKA
• 339 BKA, 531 AKA
Trauma65%
Congenital15%
Iatrogenic15%
Thermal5%
y = -0.5882x + 343.88R² = 0.0037
0
50
100
150
200
250
300
350
400
450
500
710 393 470 114 639 423 745 424 986 205 816 876 866 441 169 143
OP
ERA
TIV
E TI
ME
(MIN
)
SUBJECT ID
Ewing Amputation (Modified BKA) Operative
Times(n=16 patients)
Dissection82 (27%)
Osteotomy10 (3%)
Tunnel Harvest31 (10%)
AMI Construction91 (30%)
Bead Placement30 (10%)
RPNI Construction20 (7%)
Tailoring26 (9%)
Closure13 (4%)
Ewing Amputation (Modified BKA) Operative Time by Operative Component
(in minutes)
y = -137x + 853R² = 0.9508
0
100
200
300
400
500
600
700
800
380 947 227
OP
ERA
TIV
E TI
ME
(MIN
)
SUBJECT ID
Modified AKA Operative Times(n=3 patients)
Reported average for standard BKA
Source: Sanders et al, 2011
0%
20%
40%
60%
80%
100%
120%
A B C D E F G H I Mean
Tibial Plateau Circumference Mid-Tibial Circumference
Limb Circumference Preservation
Mean Time to
Full Narcotic Wean
Residual Limb Pain
Phantom Limb Pain
Phantom
Perception
• 77 days (range 7-181 days)
• Only reported in 3 patients who
did not undergo full RPNI
construction
• None
• “Functional” phantom
perception reported
consistently across all patients
Pain/Perception Related Outcomes
Mobility
Self Care
Usual Activities
Pain-Discomfort
Anxiety/Depression
Health Scale
0.001
0.29
0.003
<0.001
0.2
0.0004
• Significant improvement
• No effect
• Significant improvement
• Significant improvement
• No effect
• Significant improvement
SUBJECT t-TEST p
VALUE
CONCLUSION
EQ-5D Pre- vs. Post-operative Mean Survey Results
y = 7.787x + 28.171R² = 0.9453
0
10
20
30
40
50
60
70
80
90
100
BASELINE 6WEEKS 3MONTHS 6MONTHS 9MONTHS 1 YEAR
PER
CEN
T O
F M
AX
IMA
L FU
NC
TIO
N
TIMELINE
Mean LEFS Scores Over Time
PROMIS-57 Pre- vs. Post-operative Mean Survey Results
Physical
Function
Anxiety
Depression
Fatigue
Sleep
Social Roles
and
Activities
Pain
Interference
Pain Intensity
0.001
0.0069
0.002
0.0003
0.055
<0.0001
<0.0001
0.0002
29.5%
-14.0%
-8.5%
-27.25%
-11.5%
33.5%
-41.5%
-9.4%
SUBJECT t-TEST p
VALUE
%Δ
• Superficial cellulitis over constructs requiring short term oral or topical antibiotics (33%)
• Minor wound healing issues (33%)
• Major wound healing requiring operative intervention (22%)
Complications
Emerging Paradigm of Management
PROSTHESIS RECONSTRUCTIONVS&
Ewing Amputation Standard Amputation
Ewing Amputation Standard Amputation
OTHER LIMB MODELS
OSSEO-INTEGRATION
REVISIONOPTIONS
Parallel Investigations
33
AMPUTATION
SURGICAL
FAILURE
LIMB
SALVAGE
Philosophical Approach to Amputation
INCREASING RECONSTRUCTIVE SOPHISTICATION
Critical tenet of emerging notion of
functional limb restoration