Rafsos

Grb2

PTB

Ras

MAPK

Ubiquilin

Mint - 2 Mint - 3Mint - 1

Fe65

AICD

C

PS1 / PS2

Pen-2Aph - 1α1Aph - 1α2Aph - 1β

cleavageactivatesγ - secretase

γ - secretase

α - secretase

β - secretase

ADAM10ADAM17

BACE1

BACE2

- 38- 40- 42- 49

CLAC-P

Protease α2M

Aβ

Aβ Aβ

AβAβ

Aβ

Protease IDE

Protease NEP

Protease PLG

N

APP

NCT

OLIGOMERIZATION DEGRADATIONCLEARANCE / EXPORT

CYTOPLASM

Aβ

P3ApoE

ApoE ApoJ

SH2

Shc

Aβ

Aβ

Aβ

Aβ Aβ Aβ

Aβ

Aβ

YENPTY

LRP

NOTCH

ErbB4

CD44

P75N

T

R

γ secretase

E-CADHERIN

Alzheimer’s Disease: Amyloid Precursor Protein (APP) processing

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Related antibodies and proteins from Abcam: See more products at: www.abcam.com

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Antibodies Clonality Applications Host Species DatasheetReactivity www.abcam.com/ab… Featured antibodies

APH1a antibody (ab12104)

Clonality Applications Host Species cross reactivity

P IHC-FoFr, WB Rb Hu, Ms, Rat

beta Amyloid 1-42 antibody (ab10148)

Clonality Applications Host Species cross reactivity

P IHC-Fr, IHC-P, WB Rb Hu, Ms, Rat, Dog

Insulin degrading enzyme / IDE antibody (ab32216)

Clonality Applications Host Species cross reactivity

P IHC-FoFr, IHC-P, WB Rb Hu, Ms, Rat

p75 NGF Receptor antibody [ME20.4] (ab8877)

Clonality Applications Host Species cross reactivityM EM, Flow Cyt, ICC/IF, IHC-Fr, Ms Hu, Ms, Rat, Cat, Dog,

IHC-P, IP, RIA Pig, Rb, Shp

Raf1 (phospho S239) antibody (ab1095)

Clonality Applications Host Species cross reactivityP ICC/IF Rb Hu

Proteins/Peptides Applications Species Datasheetwww.abcam.com/ab…

ADAM10 antibody [mAbcam 73402] M WB Ms Hu 73402ADAM17 antibody P WB Rb Hu 77820alpha 2 Macroglobulin antibody P ICC/IF, WB Rb Hu 84176Amyloid beta precursor protein antibody [Y188] M Flow Cyt, ICC, IHC-FoFr, IHC-FrFl, IHC-P, IP, WB Rb Hu, Ms, Rat 32136Amyloid Precursor Protein (phospho Y757) antibody P IHC-FoFr, WB Rb Ms 19850APBA1 antibody P WB Rb Rat 3448Apolipoprotein E antibody P WB Rb Hu 85311BACE1 antibody P WB Rb Hu, Ms, Rat 63954BACE2 antibody P IHC-P, WB Rb Hu, Ms, Rat 8025beta Amyloid 1-40 antibody [BDI350] M ELISA, ICC, IHC-P, WB Ms Hu 20068beta Amyloid 17-42 antibody P ELISA Rb Hu 17327beta Amyloid antibody P ELISA, IHC-Fr, IHC-P Rb Hu, Ms 2539CD44 antibody P IHC-P, WB Rb Hu, Ms, Rat 41478CLACP antibody P IHC-P, WB Rb Hu, Ms 72529E Cadherin antibody P ICC/IF, WB Rb Hu 77287ErbB 4 (phospho Y1284) antibody P ELISA, ICC/IF, WB Rb Hu, Ms, Rat 61059FE65 antibody [EPR3538] M ICC, IHC-P, WB Rb Hu 91650GRB2 antibody P WB Rb Hu 79876Low Density LRP antibody [5A6] M ELISA, Flow Cyt, ICC/IF, IHC-Fr, IHC-P, WB Ms Hu, Ms, Rb 28320MEK1 antibody P ICC/IF, WB Rb Hu, Ms, Rat 42647Mint3 antibody P ICC/IF, WB Rb Ms, Rat 3450Neprilysin-like Protease beta antibody P ELISA, WB Rb Hu, Ms, Rat 81688Nicastrin antibody P WB Rb Hu, Ms, Rat 3444Notch1 antibody P IHC-P, WB Rb Hu 65297PEN2 antibody P WB Rb Hu, Ms 18189Plasminogen antibody P Conjugation, ELISA, IP, sELISA, WB Gt Hu, Rat 6189Presenilin 1 + 2 antibody P ELISA, WB Rb Hu 60120PTBP1 antibody [SH54] M ICC/IF, IHC-P, WB Ms Hu 30317Ras antibody [EP1125Y] M Flow Cyt, IP, WB Rb Hu, Ms, Rat 52939SHC antibody P ELISA, WB Rb Hu, Ms, Rat, Rb 24787Ubiquilin antibody P ICC/IF, WB Rb Hu, Ms, Hm 3341

ADAM10 protein (His tag) WB Hu 83118ADAM17 peptide (Activation site) ELISA, WB Hu 41215Amyloid beta precursor protein protein Inhib Hu 79731Amyloid Precursor Protein peptide BL Hu 7875APBA1 peptide BL Rat 4980APH1a peptide BL Hu 12394Apolipoprotein E protein SDS-PAGE Hu 91027BACE peptide BL Hu 7883BACE1 protein (Active) FuncS, SDS-PAGE Hu 73428BACE2 peptide BL Hu 8392BACE2 peptide BL Hu 5873beta Amyloid 1-42 protein (Tagged) SDS-PAGE Hu 82795CD44 peptide BL Hu 41477

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