Cell Damage Cell Damage Cell DamageCell Damage

EARLY ALLERGIC RESPONSE

LATE ALLERGIC RESPONSEWheezingUrticariaSneezingRhinorrhoeaConjunctivitis

Further WheezingSustained Nasal BlockageEczema

Allergen

MHC-

II

Dusts, Plant Pollens, DustMites, Animals, MoldSpores, Drugs, Foods,

Smoke

TCR

IL-18

IL-4

IL-5

lgE

FcεRI

lgERlgEFcεRIlgER

lgEFcεRIlgER

IL-4, IL-13

IL-4IL-9

IL-10 IL-4IL-13

IL-13

, Leu

kotri

enes

IL-3IL-5PGD-2

IL-9IL-13

GMCSFIL-5IL-3

IL-4, IL-33

APC

IL-5IL-3IL-8

TNF

Histamine

Naive CD4+

T Cell

Mast cell

Bone Marrow

EosinophilRelease

lgE lgE

B Cell

lgE

lgElgE

lgE

Eos Recruitment

Eos Migration andActivation

CytokineLipids

TSLP

MucusHypersecretion

FIBROSISTH2 Cell

Ecp EPO EDN MBP

Basophil

Mast cell

Allergen

lgE

Histamine

CD63

CD203c

Neutrophil

Histamine

Histamine

CytokinesEotaxin

IL-4, IL-6, IL-9, IL-13

Allergic Response Pathway

antibody and ELISA experts

Activation

Indirect Activation

Binding

Expression

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Enzyme Catalysis

Inhibition

Leads to

Modification

Membership

Proteolysis

Reaction (Uni)

Reaction (Bi)

Related Pathway

Translocation

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