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Akt signalingpathway

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Akt signaling related products in the Abcam Biochemicals range:

Discover more at abcam.com/biochemicals

*Sold under exclusive licence from Children’s Medical Research Institute and Newcastle Innovation Ltd. Dynole-34-2™, Dynole-31-2™, MiTMAB™, OcTMAB™, Iminodyn-22™ and Iminodyn-17™ are trademarks of Children’s Medical Research Institute and Newcastle Innovation Ltd.”

Product Biological description Purity Product code

Adenosine 3’,5’-cyclic monophosphate Second messenger. PKA activator >98% ab120493

HA-1077 ROCK2 inhibitor >98% ab120306

Honokiol Anti-inflammatory and chemotherapeutic agent > 98% ab120647

Genistein Protein tyrosine kinase inhibitor. Anticancer agent. >99% ab120112

Luteolin Antioxidant, anti-inflammatory, anti-cancer flavonoid >99% ab120662

LY 294002 PI-3 kinase inhibitor >99% ab120243

2-Methoxyestradiol Potent antitumor and antiangiogenic agent >98% ab120653

Myricetin Potent anti-neoplastic, anti-oxidant and anti-inflammatory agent >97% ab120721

NG-Monomethyl-L-arginine, monoacetate salt NOS inhibitor >99% ab120137

Nω-Nitro-L-arginine Methyl Ester hydrochloride NOS inhibitor >98% ab120136

Okadaic acid PP1 and PP2A inhibitor >98% ab120375

Phospho-Glycogen Synthase Peptide-2 GSK substrate >99% ab120079

Piceatannol Syk tyrosine kinase inhibitor >99% ab120722

Pifithrin-α-HBr p53 inhibitor >98% ab120478

PP2 Src and RIP2 kinase inhibitor >98% ab120308

PP3 Negative control for the Src kinase inhibitor PP2 >98% ab120617

Resveratrol Antioxidant polyphenol with a multitude of biological activities >98% ab120726

SB 203580 hydrochloride p38 MAP kinase inhibitor; water soluble >99% ab120235

SB 216763 Potent selective GSK-3 inhibitor >98% ab120202

Sodium salicylate Cell permeable anti-inflammatory agent >99% ab120746

SP600125 JNK inhibitor >98% ab120065

Spermidine hydrochloride Endogenous polyamine. nNOS inhibitor. >99% ab120057

Sulindac sulfide Active metabolite of Sulindac. COX-1/ 2 inhibitor. >98% ab120650

Triptolide from Tripterygium wilfordii Anti-inflammatory agent with multiple biological activities >99% ab120720

1400W Selective iNOS inhibitor >99% ab120165

Wortmannin PI3-kinase inhibitor >98% ab120148

Y-27632 dihydrochloride Selective Rho kinase inhibitor >99% ab120129

Z-D(OMe)E(OMe)VD(OMe)-FMK Cell permeable caspase-3 inhibitor >90% ab120488

ZM 336372 Potent, selective c-Raf inhibitor >98% ab120428

Z-VAD-FMK Irreversible general caspase inhibitor >98% ab120382

Dynamin inhibitors*

Dyngo-4a™ Novel, highly potent dynamin inhibitor - ab120689

Dynole-31-2™ Negative control for Dynole 34-2™ >98% ab120464

Dynole-34-2™ Potent dynamin I and dynamin II inhibitor >98% ab120463

Iminodyn-17™ Negative control for Iminodyn-22™ >98% ab120462

Iminodyn-22™ Potent, broad spectrum dynamin inhibitor >98% ab120461

OcTMAB™ Cell permeable dynamin I and dynamin II inhibitor >98% ab120467

Pro-Myristic Acid Negative control for MiTMAB™ and OcTMAB™ - ab120476

RTIL-13™ Potent dynamin I and II inhibitor >98% ab120465

GTPase

GTP GDP

Stalk AD PRDPH

Structural domains of dynamin, their function and the target sites of action of the MiTMAB™, Dynole™ and Iminodyn™ chemical series collections

GTPBinding

LipidBinding

Domain

InhibitorInteraction

• MiTMAB™• OcTMAB™• RTIL-13™

• Dynole-34-2™• Iminodyn-22™

RingAssembly

Phos/DephosProtein-Protein

World Exclusive!

Pitstop 2™ Clathrin inhibitor

Novel, selective, cell membrane permeable clathrin inhibitor.

Competitively inhibits clathrin terminal domain to selectively inhibit

clathrin mediated endocytosis (CME) (IC50 = 12 µM for inhibition

of amphiphysin association of clathrin TD). Interferes with

receptor mediated endocytosis (RME), entry of HIV and synaptic

vesicle recycling. (ab120687)

World Exclusive!

Dynamin inhibitors toolbox

The Dynamin Inhibitors Toolbox (ab120468) is a unique collection

of small molecule, potent and cell permeable dynamin inhibitors,

enabling characterization of dynamin and endocytosis. The

inhibitors have different mechanisms of action, target different

domains of dynamin, and are based on differing chemical scaffolds.

Negative controls for each chemical series are included.

Featured products

Product Biological description Purity Product code

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