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AIDS in the workplace
AH Mehrparvar,MDOccupational Medicine departmentYazd University of Medical Sciences
Introduction Human Immunodeficiency Virus A retrovirus HIV-1 and HIV-2 RNA and reverse transcriptase Enters cells expressing CD4 (a group of T
lymphocytes)
Transmission of HIV HIV isolated from:
Blood Semen Vaginal secretion Breast milk and:
Saliva Tear urine
75% of all HIV infections are due to sexual intercourse
Blood and blood products Maternal-infant
Diagnostic tests Screening
Ab against HIV (4-12 weeks later) False positive: multiple pregnancies,
transfusion, autoimmune diseases Confirmatory
Western blot: negative, indeterminate, positive Virologic markers
Pathogenesis Acute or primary infection
Fever, fatigue, pharyngitis, LAP, myalgia, rash Asymptomatic phase
7-10 years Symptomatic phase
CD4<200/mm3
Opportunistic infections: Fungal infections Herpes simplex TB
Occupational risk of HIV Directly proportional to the risk of
exposure to HIV-infected blood Jobs: HCWs Military personnel Safety/rescue personnel sporstmen
HCWs Most common: needlestick RR of percutaneous infection: 1 in 300 Influencing factors:
Quantity and depth of infection Visible blood on needle Terminal AIDS
Other exposures: Intact skin with large quantities of blood Mucous membrane exposure
Primary prevention Minimizing contact with moist body
substances and surfaces, by: Handwashing
With warm water and plain soap Antimicrobila agents are not necessary
Gloves Gowns Face shields
Primary prevention Do not recap needles Put disposable syringe, needle and other
sharp devices in puncture-resistant containers
Put containers as close as possible to use areas
Clean-up spills of blood or other body fluids with suitable germicide
Dispose of gloves last Wash the hand after disposing gloves
Secondary prevention After needlestick: Cleanse wounds If source seronegative:
Baseline test and follow-up 12 weeks later If source unknown or positive:
Chemoprophylaxis Zidovudine during 72 hours after exposure
Baseline test ant follow-up at 6, 12, and 26 weeks
Sportsmen Do not recommend routine testing Do not restrict HIV-positive athletes from
playing
Military personnel They may not serve in combat units They may not be assigned remote from
medical centers
Mortuary workers HIV in blood up to 21 hours after death HIV in bone, brain and viscera after 2
weeks