31
133 Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, M., Ponta, H., Herrlich, P., and Simon, J.C. Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid. Oncogene. 20: 33993408, 2001. Alaoui, J.M. A., XU.Y. Proteomic technology for biomarker profiling in cancer: an update. Zhejiang Univ Sci B. 7(6): 411420, 2006. Algire, G.H.,Chalkley, H. W. Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants. J. Natl Cancer Inst. USA 6, 7385, 1945. Anderson L. Candidate-based proteomics in the search for biomarkers of cardiovascular disease. J Physiol .563:23-60, 2005. Artym ,V.V., Yamada, K.M., Mueller ,S.C. ECM Degradation Assays for Analyzing Local Cell Invasion. Methods Mol Biol. 522: 1-9, 2009. Aruffo, A., Stamenkovi, I., Melnick, M., Underhill, C.B., Seed, B. CD 44 is the priniple cell surface receptor for hyaluronate. Cell.61: 1303-1313, 1990. Asplund, T., Versnel, M. A., Laurent, T. C and Heldin, P. Human mesothelioma cells produce factors that stimulate the production of hyaluronan by mesothelial cells and fibroblasts. Cancer Res. 53: 388-392, 1993. Auvinen, P. K., Parkkinen, J.J., Johansson, R.T., Agren, U.M., Tammi, R.H., Eskelinen, M.J and Kosma, V.M. Expression of hyaluronan in benign and malignant breast lesions. Int J Cancer. 74: 477-81, 1997. Baltimore , H. L. , Arnold, B.S,. Lawrence ,Z., Paul,M and James,D. Molecular cell biology .3 rd edition , W. H. Freeman and co , New York, 1995 . Banerjee, S.D and Toole, B.P. Monoclonal antibody to chick embryo hyaluronan- binding protein: changes in distribution of binding protein during early brain development. Dev. Biol.146, 186-197, 1991.

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133

Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, M., Ponta, H.,

Herrlich, P., and Simon, J.C. Soluble CD44 inhibits melanoma tumor growth by

blocking cell surface CD44 binding to hyaluronic acid.

Oncogene. 20: 3399–3408, 2001.

Alaoui, J.M. A., XU.Y. Proteomic technology for biomarker profiling in cancer: an

update.

Zhejiang Univ Sci B. 7(6): 411–420, 2006.

Algire, G.H.,Chalkley, H. W. Vascular reactions of normal and malignant tissues in

vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic

transplants.

J. Natl Cancer Inst. USA 6, 73–85, 1945.

Anderson L. Candidate-based proteomics in the search for biomarkers of

cardiovascular disease.

J Physiol .563:23-60, 2005.

Artym ,V.V., Yamada, K.M., Mueller ,S.C. ECM Degradation Assays for Analyzing

Local Cell Invasion.

Methods Mol Biol. 522: 1-9, 2009.

Aruffo, A., Stamenkovi, I., Melnick, M., Underhill, C.B., Seed, B. CD 44 is the

priniple cell surface receptor for hyaluronate.

Cell.61: 1303-1313, 1990.

Asplund, T., Versnel, M. A., Laurent, T. C and Heldin, P. Human mesothelioma cells

produce factors that stimulate the production of hyaluronan by mesothelial cells and

fibroblasts.

Cancer Res. 53: 388-392, 1993.

Auvinen, P. K., Parkkinen, J.J., Johansson, R.T., Agren, U.M., Tammi, R.H.,

Eskelinen, M.J and Kosma, V.M. Expression of hyaluronan in benign and malignant

breast lesions.

Int J Cancer. 74: 477-81, 1997.

Baltimore , H. L. , Arnold, B.S,. Lawrence ,Z., Paul,M and James,D.

Molecular cell biology .3rd

edition , W. H. Freeman and co , New York, 1995 .

Banerjee, S.D and Toole, B.P. Monoclonal antibody to chick embryo hyaluronan-

binding protein: changes in distribution of binding protein during early brain

development.

Dev. Biol.146, 186-197, 1991.

Page 2: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

134

Banerjee, S.D and Toole, B.P. Hyaluronan-binding protein in endothelial cell

morphogenesis.

J Cell Biol. 119: 643-652, 1992.

Banks,R.E.,Gearing,A.J.H.andHemingway,I.K.circulating ICAM-1,E-selsction and

VCAM-1 in human malignancies.

Br.J.Cancer.68: 122-124, 1993.

Bartolazzi, A., Peach, R., Aruffo, A., and Stamenkovic, I. Interaction between CD44

and hyaluronate is directly implicated in the regulation of tumor development.

J. Exp. Med.180:53–66, 1994.

Basil. C.F., Zhao, Y., Zavaglia, K., Jin, P., Panelli, M.C., Voiculescu, S.,

Mandruzzato, S., Lee, H.M., Seliger, B., Freedman, R.S., Taylor, P.R., Hu, N.,

Zanovello, P., Marincola, F.M. and Wang, E. Common cancer biomarkers.

Cancer Res. 66: 2953-2961, 2006.

Bast, R.C Jr., Lilja, H., Urban, N., Rimm, D.L., Fritsche, H., Gray, J., Veltri, R., Klee,

G., Allen, A., Kim, N., Gutman, S., Rubin, M.A and Hruszkewycz, A. Translational

crossroads for biomarkers.

Clin Cancer Res.11: 6103-6108, 2005.

Bertrand, P., Girard, N., Delpech, B., Duval, C., d’Anjou, J and Dauce, J.P

Hyaluronan (hyaluronic acid) and hyaluronectin in the extracellular matrix of human

breast carcinomas: comparison between invasive and non-invasive areas.

Int. J. Cancer. 52:1–6, 1992.

Bidart, J.M., Thuillier ,F., Augereau ,C., Chalas ,J., Daver, A., Jacob ,N., Labrousse,

F., Voitot, H..Kinetics of serum tumor marker concentrations and usefulness in

clinical monitoring.

Clin. Chem. 45:1695-1707, 1999.

Bidard, F,C.,Pierga,J,Y., Vincent-Salomon,A., Poupon,M.F.A .class action against the

microenvironment: do cancer cells cooperate in metastasis?

Cancer Metastasis Rev. 27: 5-10, 2008

Bishop,J.M. Molecular themes in oncogenesis.

Cell, 64:235-248, 1991.

Bitter, T and Muir, H.M.Amodified uronic acid carbozole reaction.

Anal.Biochem.4:330-334.1962.

Page 3: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

135

Blundell, C.D., Mahoney, D.J., Almond, A., DeAngelis, P.L., Kahmann, J.D., Teriete,

P., Pickford, A.R., Campbell, I.D and Day, A.J. The link module from ovulation

andinflammation associated protein TSG-6 changes conformation on hyaluronan

binding.

J. Biol. Chem. 278: 49261–49270, 2003.

Boregowda, R. K., Hitesh, N.A., Manjunath, S., Sunil B.K., Sunila Sunila.,

Thimmaiah K.N.,KarunaKumar, M., Bryan Toole., and Shib d Banerjee. Expression

of Hyaluronan in human tumour progression.

J Carcinog. 5: 2, 1-9,2006.

Borsig,L.,Wong,R.,Hynes,R,O.,Varki,N.M and Varki,A.Synergistic effects of L- and

P-selectin in facilitating tumor metastasis can involve non-mucin ligands and

implicate leukocytes as enhancers of metastasis.

Proc Natl Acad Sci U S A, 99:2193-2198, 2002.

Bosl,G,J., Bajorin, D,F., Sheinfeld ,J., Motzer,R.J., Chaganti,R.S. Cancer of the testis.

In: DeVita VT, Hellman S, Rosenberg SA, et al., eds.

Cancer, principles and practice of oncology. 6th ed. Philadelphia: Lippincott,

Williams & Wilkins:1491–1518, 2001.

Bot, P.T., Hoefer, I.E., Piek,J.J., Pasterkamp,G. Hyaluronic Acid: targeting immune

modulatory components of the extracellular matrix in atherosclerosis.

Curr Med Chem.15:786–791, 2008.

Bouck, N., Stellmach, V. & Hsu, S. C. How tumours become angiogenic. Adv.

Cancer Res. 69,135–174, 1996.

Bourguignon, L.Y. CD44-mediated oncogenic signaling and cytoskeleton activation

during mammary tumour progression.

J. Mammary Gland Biol, Neoplasia . 6: 287–297, 2001.

Bourguignon, L.Y., Singleton, P.A and Diedrich, F. Hyaluronan-CD44 interaction

with Rac1-dependent protein kinase N-gamma promotes phospholipase Cgamma1

activation, Ca(2+) signaling, and cortactin-cytoskeleton function leading to

keratinocyte adhesion and differentiation.

J Biol Chem. 279: 29654-29669, 2001.

Bradford, M. M. A rapid and sensitive method for quantitation of microgram

quantities of protein utilizing the principle of protein-dye-binding.

Anal Biochem.72:248-254,1976

Page 4: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

136

Brat,D,J., Lillemoe,K.D., Yeo,C.J., Warfield,P.B and Hruban, R.H. Progression of

pancreatic intraductal neoplasias to infiltrating adenocarcinoma

of the pancreas.

Am J Surg Pathol. 22:163-169, 1998

Braun ,S., Pantel, K., Muller ,P., Janni ,W., Hepp F., Kentenich, C.R., Gastroph, S.,

Wischnik A, Dimpfl,T., Kindermann,G., et al. Cytokeratin-positive cells in the bone

marrow and survival of patients with stage I, II, or III breast cancer.

N Engl J Med.342(8):525–533,2000.

Calabro, A., Oken, M. M., Hascall, V. C and Masellis, A. M. Characterization of

hyaluronan synthase expression and hyaluronan synthesis in bone marrow

mesenchymal progenitor cells: predominant expression of HAS1 mRNA and up-

regulated hyaluronan synthesis in bone marrow cells derived from multiple myeloma

patients.

Blood.100: 2578–2585, 2002.

Califano,J., Ahrendt ,S.A., Meininger, G., Westra ,W.H., Koch, W.M., Sydransky

D.Detection of telomerase activity in oral rinses from head and neck squamous cell

carcinoma patients.

Cancer Res.56:5720 – 5722, 1996.

Cannistra ,S.A., Abu-Jawdeh, G., Niloff, J., Strobel, T., Swanson, L., Andersen ,J and

Ottensmeier, C. CD44 variant expression is a common feature of epithelial ovarian

cancer: Lack of association with standard prognostic factors.

J Clin Oncol. 13: 1912-1921, 1995.

Carmeliet, P. Controlling the cellular brakes.

Nature 401, 657–658 ,1999.

Catalona,W.J., Richie ,J.P., Ahmann ,F.R., Hudson ,M.A., Scardino ,P.F., Flanigan

,R.C, et al. Comparison of digital rectal examination and serum prostate specific

antigen in the early detection of prostate cancer: results of a multicenter clinical trial

of 6,630 men.

J Urol.151:1283–1290, 1994.

Cavenee ,W.K., Dryja ,T.P., Phillips, R.A., Benedict,W.F., Godbout,R and Gallie,B.L

.Expression of recessive alleles by chromosomal mechanisms in retinoblastoma.

Nature. 305:779-784,1983.

Chaly, N., Bladon ,T., Setterfield ,G., Little, J .E., Kaplan ,J .G., and Brown, D. L.

Changes in distribution of nuclear matrix antigens during the mitotic cell cycle.

The Journal of cell biology. 99:661-671, 1984.

Page 5: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

137

Chan ,D.W., Beveridge ,R.A., Muss ,H., Fritsche ,H.A., Hortobagyi ,G., Theriault ,R.,

et al. Use of Truquant BR radioimmunoassay for early detection of breast cancer

recurrence in patients with stage II and stage III disease.

J Clin Oncol .15:2322–2328,1997.

Chen ,D.X., Schwartz ,P.E., Li ,X.G., Yang ,Z. Evaluation of CA 125 levels in

differentiating malignant from benign tumours in patients with pelvic masses.

Obstet Gynecol .72:23–27,1988.

Choy, A., Culloch,P.M.c. Induction of tumour cell shedding into effluent venous

blood breast cancer surgery.

Br J Cancer.73:79-82, 1996.

Chun, S.J., Bae, O.S., Kim, J.B. The significance of CD44 variants expression in

colorectal cancer and its regional lymph nodes.

J KoreanMed Sci. 15: 696-700,2000.

Corney DC., Flesken-Nikitin A , Choi J , Nikitin AY. Role of p53 and Rb in ovarian

cancer.

Adv Exp Med Biol. 622: 99-117, 2008.

Cristofanilli, M., Budd, G.T., Ellis, M.J, et al. circulating tumor cells, disease

progression, and survival in metastatic breast cancer.

NEnglJMed.351:781-791, 2004.

Csoka, A., Scherer,S and Stern, R. Expression analysis of six paralogous human

hyaluronidase genes clustered on chromosomes 3p21 and 7q31.

Genomics.60:351-361, 1999.

Culloch, P., Choy, A., Martin, L. Association between tumour angiogenesis and

tumour cell shedding into effluent venous blood during breast cancer surgery.

Lancet. 346: 1334-1335,1995.

Culty, M, O'mara., Underhill, T.E., Yeager, C. B and Jr, Swartz, R.P. Hyaluronan

receptor (CD44) expression and function in human peripheral blood monocytes and

alveolar macrophages.

J. Leuk. Biol.56: 605–611, 1994.

Cutforth, T and Rubin, G.M. Mutations in Hsp 83 and Cdc 37 impair signalling by the

sevenless receptor tyrosine kinase in Drosophila.

Cell. 77:1027-1036, 1994.

Page 6: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

138

Dacai, L., Eric, P., Eugenia ,D., Kun,G., Hiroshi ,M., Tariq,H., Sanford,M., James,W.,

and Man-Sun Sy. Expression of hyaluronidase by tumour cells induces angiogenesis

in vivo.

PNAS .93: 7832-7837, 1996.

Dahl, I.M., Turesson, I., Holmberg, E., Lilja, K. Serum hyaluronan in patients with

multiple myeloma: correlation with survival and Ig concentration.

Blood. 93: 4144-4148, 1999.

Day, A. J. The structure and regulation of hyaluronan-binding proteins.

Biochem. Soc. Trans. 27, 115–121,1999.

Day, A. J and Sheehan, J. K. Hyaluronan: polysaccharide chaos to protein

organisation.

Current opinion in structural biology. 11(5):617-622, 2001.

Day, A. J and Prestwich, G. D. Hyaluronan-binding proteins, tying up the giant.

J. Biol. Chem. 277: 4585–4588, 2002.

Deb, T.B and Datta, K. Molecular cloning of human fibroblast hyaluronic acid-binding

protein confirms its identity with P-32, a protein co-purified with splicing factor SF2.

J Biol Chem. 271:2206-2212, 1996.

DeGrendele, C. H., P. Estess, and L. J. Picker & M. H. Siegelman. CD44 and its ligan

hyaluronate mediate rolling under physiologic flow: A novel lymphocyte-endothelial

cell primary adhesion pathway.

J Exp Med. 183: 1119-1130, 1996.

Delmage, J.M., Powars, D.R., Jaynes, P.K and Allerton, S.E. The selective

suppression of immunogenicity by hyaluronic acid.

Ann. Clin. Lab. Sci. 16: 303–310, 1986.

Delpech , B., Bertrand, P. & Maingonnat, C. Immunoenzymoassay of the hyaluronic

acid-hyaluronectin interaction Application to the detection of hyaluronic acid in

serum of normal subjects and cancer patients.

Anal. Biochem.149: 555,1985.

Delpech, B., Chevallier, B., Reinhardt ,N., Julien, J.P., Duval, C., Maingonnat, C., et

al. Serum hyaluronan (hyaluronic acid) in breast cancer patients.

Int J Cancer. 15; 46: 388-390, 1990.

Page 7: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

139

Delpech, B., Maingonnant ,C., Girard ,N., Chauzy, C., Maunoury, R., Olivier, A.,

Tayot ,J., Creissard P. Hyaluronan and hyaluronectin in the extracellular matrix of

human brain tumor stroma.

Euro J Cancer. 29A:1012-1017, 1993.

Denley,A., Kang,S., Karst,U., Vogt,P.K. Oncogenic signaling of class I PI3K

isoforms.

Oncogene. 27: 2561-2574, 2008.

Dennis, M.S., Zhang ,M., Meng,Y.G., Kadkhodayan ,M., Kirchhofer, D., Combs,D.,

et al. Albumin binding as a general strategy for improving the pharmacokinetics of

proteins.

J Biol Chem. 277:35035–35043,2002.

Devilee, P., Schuuring, E., van de Vijver, M. J and Cornelisse, C. J. Recent

developments in the molecular genetic understanding of breast cancer.

Crit. Rev. Oncogen. 5:247–270, 1994.

Dong, W.G., Sun, X.M., Yu,B.P., Luo,H.S., Yu,J.P. Role of VEGF and CD44v6 in

differentiating benign from malignant ascites.

World J Gastroenterol. 11: 2596-2600, 2003.

Duffy M. J. Carcinoembryonic Antigen as a Marker for Colorectal Cancer: Is It

Clinically Useful?

Clinical Chemistry. 47:4, 624-630, 2001.

Dwivedi,C., Dixit,M., Hardy,R.E. Plasma lipid-bound sialic acid alterations in

neoplastic diseases.

Experientia;46:91–97, 1990.

Ehrmann, R. L. & Knoth, M. Choriocarcinoma. transfilter stimulation of

vasoproliferation in the hamster cheek pouch studied by light and electron

microscopy.

J. Natl Cancer Inst. 41:1329–1341, 1968.

Entwistle, J., Hall, C, L and Turely, E.A. HA receptors. Regulation of Signalling to the

Cytoskeleton.

J.Cell.Biochem. 61:569-577, 1996.

Etzioni, R., Etzioni,R., Urban ,N., Ramsey ,S., McIntosh, M., Schwartz, S., Reid, B.,

Radich, J., Anderson ,G., Hartwell, L.The case for early detection.

Nat. Rev. Cancer. 3:243-252, 2003.

Page 8: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

140

Evanko, S.P., Wight, T.N., Intracellular localization of hyaluronan in proliferating

cells. J Histochem Cytochem. 47:1331-1342,1999.

Evanko ,S.P., Johnson, P.Y., Braun, K.R., Underhill,C.B., Dudhia ,J., Wight,T.N.

Platelet-derived growth factor stimulates the formation of versican-hyaluronan

aggregates and pericellular matrix expansion in arterial smooth muscle cells.

Arch Biochem Biophys.394:29–38, 2001.

Fedi, P., Tronick, S.R., and Aaronson, S.A. Growth factors In Cancer, R.C. Bast, D.L.

Morton, E. Frei D.W. Kufe, and R.R. Weichselbaum, eds (Baltimore, MD: Williams

and Wilkins).

Medicine, J.F. Holland, pp. 41–64,1997.

Feinberg, R.N and Beebe, D.C. Hyaluronate in vasculogenesis.

Science. 220:1177–1179, 1983.

Feinberg, A.P., Ohlsson, R and Henikoff, S. The epigenetic progenitor origin of

human cancer.

Nat.Rev.Genet. 7: 21-33, 2006.

Fenderson, B.A., Stamenkoyic and L, Aruffo., A, Localization of hyaluronan in

mouse embryos during implantation, gastrulation and organogenesis.

Differentiation. 54: 85-98, 1993.

Ferguson, J., Ho, J-Y., Peterson, T.A and Reed, S.I. Nucleotide sequence of the yeast

cell division cycle start genes CDC 28, CDC 36, CDC 37, & CDC 39 and a structural

analysis of the predicted products.

Nucleic Acids Res. 14, 6681-6697, 1986.

Firestone, G.L and Wingoth, SD, Immunonoprecipitation of proteins.

Meth Enzymol. 182: 688-700, 1990.

Folkman ,J., Cole,P., Zimmerman,S. Tumor behavior in isolated perfused organs: in

vitro growth and metastases of biopsy material in rabbit thyroid and canine intestinal

segment.

Ann Surg. 164:491–502, 1966.

Folkman J. Tumor angiogenesis: therapeutic implications.

N Engl J Med.285:1182–1186,1971.

Folkman, J. in Cancer Medicine (eds Holland, J. F. et al.)

132–152, Decker, Ontario, Canada, 2000.

Page 9: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

141

Forsburg,S.L and Nurse,P. Cell cycle regulation in the yeasts Saccharomyces cerevisiae

and Schizosaccharomyces-Pombe.

Annu. Rev. Cell Biol. 7:227-256,1991

Fowler JE Jr, Platoff GE, Kubrock CA, Stutzman RE. Commercial

radioimmunoassay for beta subunit of human chorionic gonadotropin: falsely positive

determinations due to elevated serum luteinizing hormone.

Cancer;49:136–139,1982.

Fox, S.B., Leek, R.D., Bliss, J., et al. Association of tumor angiogenesis with bone

marrow micrometastases in breast cancer patients.

J Natl Cancer Inst. 89: 1044-1049, 1997.

Franzmann, E. J., Erika ,P. R., Kermit,L. Carraway, K, L., Hamilton, Donald,T. Weed

and Jarrard Goodwin, W. Expression of tumour markers hyaluronic acid and

hyaluronidase (HYAL1) in head and neck tumours.

Int. J. Cancer. 106, 438–445, 2003.

Franzmann,E.J.,Reategui,E.P.,Pedroso,F.,Pernas,F.G.,Karakullukcu,Baris,M.,Carrawa

y,K. L., Hamilton,K., Singal,R., Goodwin,W.J. Soluble CD44 Is a Potential Marker

for the Early Detection of Head and Neck Cancer.

Cancer Epidemiology Biomarkers & Prevention.16:1348-1355, 2007.

Fraser, J. R. E., Kimpton, W. G., Laurent, T. C., Cahill, R. N. P., and Vakakis, N.

Uptake and degradation of hyaluronan in lymphatic tissue.

Biochem. j .256: 153-158,1988.

Fraser, J. R. E., and Laurent, T C. Turnover and metabolism of hyaluronan. In The

Biology of Hyaluronan.

Ciba Foundation Symp.143: 41-59, England ,1989.

Fraser,J.R.E.,Cahill,R.N,P., Kimpton,W.G., Laurent,T.C. Lymphatic system. In:

Comper WD, ed. Extracellular Matrix. 1. Tissue Function. Amsterdam:

Harwood Academic Publications; pp. 110–131,1996.

Fraser,J.R.E., Laurent,T.C., Laurent,U.B.Hyaluronan. Its nature, distribution,

functions and turnover.

J Intern Med 242, 27-33, 1997.

Frebourg T, Delpech B, Bercoff E et al. Serum hyaluronate in liver diseases: Study by

enzymoimmunological assay.

Hepatology. 6:392-395, 1986.

Page 10: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

142

Friedrichs,K., Franke,F., Lisboa, B.W., Kugler, G., Gille ,I., Terpe, H.J., Hoizel

,F.,Maass, H and Gunthert ,U. CD44 isoforms correlate with cellular differentiation

but not with prognosis in human breast cancer.

Cancer Res. 55:5424-5433, 1995.

Fries,H., Elsasser,H.P., Mahlbacher,V., Neumann,K., Kern,H.F. Localization of

hyaluronate (HA) in primary tumors and nude mouse xenografts of human pancreatic

carcinomas using abiotinylated HA-binding protein.

Virchows Archiv. 424: 7-12, 1994.

Fukumura, D.,et al. Tumor induction of VEGF promoter activity in stromal cells.

Cell 94, 715–725,1998.

Gadducci, A., Ferdeghini ,M., Cosio,S., Annicchiarico, C., Fanucchi ,A., Prontera,C.,

Bianchi ,R., Genazzani ,A.R.The serum assay of soluble CD44 standard (sCD44-st),

CD44 splice variant 5 (sCD44-v5), and CD44 splice variant 6 (sCD44-v6) in patients

with cervical cancer.

Anticancer Res. Jan-Feb18(1B):537-539, 1998.

Gakunga, P, Frost G, Shuster S, Cunha G, Formby B, Stern R. Hyaluronan is a

prerequisite for ductal branching morphogenesis.

J. Development. 124:3987-3997, 1997.

Gerber, M,R., Farrell, A., Deshaies, R.J., Herskowitz, I and Morgan, D.O. Cdc37 is

required for association of the protein kinase Cdc28 with Gl and mitotic cyclins.

Proc. Natl. Acad. Sci. 92: 4651-4655, 1995.

Ghatak., S, Misra., S, Toole., B.P. Hyaluronan constitutively regulates ErbB2

phosphorylation and signalling complex formation in carcinoma cells.

J Biol Chem. 280:8875-8883, 2005.

Ghosh, A., Wang, X., Klein, E., Heston, W.D. Novel role of prostate-specific

membrane antigen in suppressing prostate cancer invasiveness.

Cancer Res. 65:727-731, 2005.

Gion ,M., Mione ,R., Leon ,A.E., Dittadi ,R. Comparison of the diagnostic accuracy

of CA27.29 and CA15.3 in primary breast cancer.

Clin Chem.45:630–637, 1999.

Gmachl,M., Sagan, S., Ketter,S., Kreil,G. The human sperm protein PH-20 has

hyaluronidase activity.

FEBS Lett. Dec 28;336(3):545-548, 1993.

Page 11: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

143

Goebeler, M., Kaufmann, D., Brocker, E.B and Klein ,C.E. Migration of highly

aggressive melanoma cells on hyaluronic acid is associated with functional changes,

increased turnover and shedding of CD44 receptors.

J. Cell. Sci. 109:1957 - 1964. 1996.

Goi,T., Yamaguchi,A., Seki K, Nakagawara ,G., Urano,T., Shiku,H., Furukawa,K.

Soluble protein encoded by CD44 variant exons 8-10 in the serum of patients with

colorectal cancer. Br J Surg.84: 1452-1453,1997.

Goldman, E. The growth of malignant disease in man and the lower animals with

special reference to the vascular system.

Lancet 2, 1236–1240, 1907.

Gordon, L.M., Curtain,C.C., McCloyn,V., Kirkpatrick,A., Mobley,P.W., etal. The

amino-terminal peptide of HIV-1 gp41 interacts with human serum albumin.

AIDS Res Hum Retroviruses. 9:1145–1156,1993.

Goyette, M. C., Cho, K., Fasching, C. L., Levy, D. B., Kinzler, K. W and Paraskeva,

C. Progression of colorectal cancer is associated with multiple tumor suppressor gene

defects but inhibition of tumorigenicity is accomplished by correction of any single

defect via chromosome transfer.

Mol. Cell. Biol. 12: 1387–1395, 1992

Grammatikakis, N., Grammatikakis, A., Yoneda, M., Yu, Q., Banerjee, S.D and Toole,

B.P. A novel glycosaminoglycan-binding protein is the vertebrate homologue of the cell

cycle control protein, Cdc37.

J Biol Chem. 270:16198-16205, 1995.

Granger, H.J., Laine, G.A., Barnes, G.E and Lewis, R.E. Dynamics and control of

transmicrovascular fluid exchange.

In: Staub, N.C., Taylor, A.E. (Eds.) Edema. Raven Press, New York, pp. 189–228,

1984.

Green, S.J., Tarone, G and Underhil, B l. Aggregation of macrophages and fibroblasts

is inhibited by a monoclonal antibody to the hyaluronate receptor.

Journal Cell Science. 89:145-156, 1988.

Greenblatt, M. & Shubik, P. Tumor angiogenesis: transfilter diffusion studies in the

hamster by the transparant chamber technique.

J. Natl Cancer Inst. 41, 111–124 ,1968.

Greg l. Perkins, m.d., evan d. Slater, m.d., georganne k. Sanders, m.d., and john g.

Prichard, m.d., Ventura County Medical Center, Ventura, California.

Am Fam Physician. Sep 15;68(6):1075-1082, 2003.

Page 12: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

144

Gronbaek,K and Guldberg,P. Acquired mutations--basic cancer biology.

Ugeskr Laeger. 168: 2335-2338, 2006.

Gronborg, M.., Kristiansen, T. Z., Iwahori, A.,Chang, R.,Reddy, R., Sato, N., Molina,

H., Jensen, O. N., Hruban, R. H., Goggins, M. G., Maitra, A., Pandey, A. Biomarker

discovery from pancreatic cancer secretome using a differential proteomic approach

Mol. Cell. Proteomics. 5 (1): 157– 171, 2006.

Gullino, P. M. Angiogenesis and oncogenesis.

J. Natl Cancer Inst. 61: 639–643 ,1978.

Guo, Y.J.,Liu,G.,Wang,X.et al., Potential use of soluble CD44 in serum as indicator

of tumour burden and metastasis in patients with gastric or colon cancer.

Cancer Res.54:422-426, 1994.

Guo, Y., Ma, J., Wang, J., Che, X., Narula, J., Bigby, M., Wu, M., and Sy, M.S.

Inhibition of human melanoma growth and metastasis in vivo by anti-CD44

monoclonal antibody.

Cancer Res., 54, 1561–1565, 1994.

Gunthert ,U.,Hofman, R., Ruby, W., Ruber,S.,Zoller , M., Haussman ,I., matzku,

S.,Weszel ,A., Ponta, H and Herrlich ,P. A new variant of glycoprotein CD44 confers

metastatics potential to rat carcinoma cells.

Cell .65:13-24, 1991.

Hall, C.L., Yang, B., Yang, X., Zhang, S., Turley, M., Samuel, S., Lange, L.A., Wang, C,

Curpen, G.D., Savani, R.C., Greenberg, A.H and Turley, E.A. Overexpression of the

hyalurnan receptor RHAMM is transforming and is also required for H-ras

transformation.

Cell. 82:19-28, 1995.

Hall, M and Peters, G. Genetic alterations of cyclins, cyclin-dependent kinase and cdk

inhibitors in human cancer.

Adv. Cancer Res. 68: 67-108, 1996.

Hallgren, R., Engstrom- -Lauren, A. & Nisbeth, A.Circulating hyaluronate. A

potential marker of altered metabolism of the connective tissue in uremia.

Nephron.46:150, 1987.

Hanahan, D. & Weinberg, R. A. The hallmarks of cancer.

Cell 100, 57–70, 2000.

Page 13: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

145

Harada,N., Mizoi,T., Kinouchi,M., Hoshi,K., Ishii,S., Sasaki ,I., Matsuno, S.

Introduction of antisense CD44s CDNA down-regulates expression of overall CD44

isoforms and inhibits tumour growth and metastasis in highly metastatic colon

carcinoma cells.

Int J Cancer.91: 67-75, 2001.

Hardwick, C., Hoare, K., Owens, R., Hohn, H. P., Hook, M., Moore, D., Cripps, V.,

Austen, L., Nance, D. M and Turley, E. A. Molecular cloning of a novel hyaluronan

receptor that mediates tumour cell motility.

J. Cell Biol. 117: 1343-1350, 1992.

Hautmann, S, H., Schroeder, G, L., Civantos, F., Duncan, R.C., Gnann, R., Friedrich,

M.G., et al.Hyaluronic acid and hyaluronidase. 2 new bladder carcinoma markers.

Urologe A. 40: 121-126, 2001.

Heng,H.H.Q., Spyropoulos,B., Moens ,P. FISH technology in chromosome and

genome research.

BioEssays. 19:75-84, 1997.

Heng,H.H.Q, Krawetz,S.A., Lu ,W., Bremer, S., Liu, G., Ye, C.J. Re-defining the

chromatin loop domain.

Cytogent Cell Genet.93:155-161, 2001.

Higashikawa, K., Yokozaki, H., Ue, T., Taniyama, K., Ishikawa, T., Tarin, D and

Tahara, E. Evaluation of CD44 transcription variants in human digestive tract

carcinomas and normal tissues.

Int J Cancer. 66: 11–17, 1996.

Hiltunen, E.L., Anttila, M., Kultti, A., Ropponen, K., Penttinen,J., Yliskoski,M.,etal.

Elevated hyaluronan concentration without hyaluronidase activation in malignant

epithelial ovarian tumors.

Cancer Res. 62: 6410-6413, 2002.

Hiscock, D.R., Yanagishita, M and Hascall, V.C. Nuclear localization of

glycosaminoglycans in rat ovarian granulosa cells.

J. Biol. Chem. 269:4539-4546,1994.

Hobarth, K., Marier, U and Marberger., M. Tropical chemoprophylaxis of bladder

cancer by mitomycin C and hyaluronidase.

Eur. Urol. 21:206-210,1992.

Hoon, D.S., Bostick, P., Kuo,C., et al. Molecular markers in blood as surrogate

prognostic indicators of melanoma recurrence.

Cancer Res.60:2253 -2257, 2000.

Page 14: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

146

Hopwood, J., Dorfman ,A. Glycosaminoglycan synthesis by Wilms' tumor.

Pediatr Res. 12(1):52-56, 1978.

Horai, T., Nakamura, N., Tateishi, R and Hattori, S. Glycosaminoglycans in human

lung cancer.

Cancer (Phila.). 48:2016-2021, 1981.

Hu,Y.C., Sidransky, D., Ahrendt, S.A. Molecular detection approaches for smoking

associated tumors.

Oncogene.21:7289 – 7297, 2002.

Huang, L., Grammatikakis, N., Yoneda, M., Banerjee, S.D and Toole, B.P. Molecular

characterization of a novel intracellular hyaluronan-binding protein.

J Biol Chem. 275:29829-29839, 2000.

Hugosson, J., Aus,G., Lilja,H., Lodding,P., Pihl ,C.G., Pileblad ,E. Prostate specific

antigen based biennial screening is sufficient to detect almost all prostate cancers

while still curable.

J. Urol. 169:1720-1723, 2003.

Hyodo, L., Jinno, K., Tanimizu, M. et al. Detection of circulating ICAM-1 in

hepatocellular carcinoma.

Int.J.Cancer.55:775-779,1993.

Ibora, F., Cook, P.R., Jackson, D.A. Applying microscopy to the analysis of nuclear

structure and function.

Methods.29:131-141 2003.

Ide, A. G., Baker, N. H. & Warren, S. L. Vascularization of the Brown-Pearce rabbit

epithelioma transplant as seen in the transparent ear chamber.

Am. J. Radiol. 42: 891–899, 1939.

Iida, N and Bourguignon, L.Y. Coexpression of CD44 variant (vl0/exl4) and CD44S

in human mammary epithelial cells promotes tumorigenesis.

J Cell Physiol. 171:152-160,1997.

Inger, S., and Laurent, T.C. Concentration of Hyaluronan in the Serum of Untreated

Cancer Patients with Special Reference to Patients with Mesothelioma.

Cancer. 62:326-330, 1988.

Iozzo, R and Muller-Glauser, W. Neoplastic modulation of extracellular matrix:

proteoglycan changes in the rabbit mesentery induced by V2 carcinoma cells

Cancer Res. 45: 5677-5687, 1985.

Page 15: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

147

Iozzo, R.V. Matrix proteoglycans: from molecular design to cellular function.

Annu Rev Biochem. 67:609-652, 1998.

Ishihara, M., Fedarko, N.S and Conrad, H.E. Transport of heparan sulfate in to the

nuclei of hepatocytes.

J. Biol. Chem. 261: 13575-13580, 1986.

Itano, N., Sawai, T., Yoshida, M., Lenas, P., Yamada, Y., Imagawa, M.,Shinomura,

T., Hamaguchi, M.,Yoshida,Y., Ohnuki,Y., Miyauchi, S., Spicer, McDonald A. P, J.

A and Kimata, K.. Three isoforms of mammalian hyaluronan synthases have distinct

enzymatic properties.

J. Biol. Chem. 274:25085 – 25092, 1999.

Itano,N.Simple primary structure, complex turnover regulation and multiple roles of

hyaluronan.

J Biochem. 144(2):131-137, 2008.

Jacobs, I and Bast, R.C.J. The CA 125 tumour-associated antigen.

Hum Reprod..4(1):1-12,1989.

Jakson, A.M., Alexandrov, A.B., Gribben, S.C.et al.Expression and shedding of

ICAM-1 in bladder cancer and its immunotherapy.

Int.J.Cancer.55:921-925, 1993.

Jauch,K.W., Heiss,M.M., Gruetzner,U.,et al. Prognostic significance of bone marrow

micrometastases in patients with gastric cancer.

J Clin Oncol. 14: 1810-1817, 1996.

Johnson, P.J. The role of serum alpha-fetoprotein estimation in the diagnosis and

management of hepatocellular carcinoma.

Clin Liver Dis.5:145–159, 2001.

Jortani, S.A., Prabhu, S.D., Valdes (Jr.), R. Strategies for developing biomarkers of

heart failure.

Clin. Chem. 50:265-278,2004.

Jung, C.S., Foerch ,C., Schänzer, A., Heck, A.,Plate, K. H., Seifert ,V., Steinmetz, H.,

Raabe ,A and Sitzer, M .Serum GFAP is a diagnostic marker for glioblastoma

multiforme

Brain. 130: 3336-3341, 2007.

Page 16: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

148

Karjalainen, J. M. Reduced level of CD44 and hyaluronan associated with

unfavorable prognosis in clinical stage I cutaneous melanoma.

Am. J. Pathol. 157: 957–965, 2000.

Karvinen, S., Kosma, V. M., Tammi, M. I and Tammi, R. Hyaluronan, CD44 and

versican in epidermal keratinocyte tumours.

Br. J. Dermatol. 148: 86–94, 2003.

Kaufmann, M., Heider, K.H., Sinn, H.P., Von Minckwitz ,G., Ponta ,H and Herrlich

,P. CD44 variant exon epitopes in primary breast cancer and length of survival.

Lancet.345: 615-619, 1995.

Kaya, G., Rodriguez, I., Jorcano, J. L., Vassalli, P and Stamenkovic, I. Selective

suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene

driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and

impairs keratinocyte proliferation.

Genes Dev. 11: 996–1007, 1997.

Kerbel, R. S. Tumor angiogenesis: past, present and the near future.

Carcinogenesis. 21: 505–515, 2000.

Kim, S.Y., Toretsky,J.A., Scher,D., Helman,L.J. The role of IGF-1R in pediatric

malignancies.

Oncologist. 14: 83-91, 2009.

Kimata, K., Honma, Y., Okayama, M., Oguri, K., Hozumi, M and Suzuki, S.,

Increased synthesis of hyaluronic acid by mouse mammary carcinoma cell variants

with high metastatic potential.

Cancer Res.43: 1347–1354, 1983.

Kinzler, K.W., and Vogelstein, B.Lessons from hereditary

colorectal cancer. Cell 87: 159–170,1996.

Kinzler, K. W. and Vogelstein, B. Landscaping the cancer terrain.

Science .280:1036–1037, 1998.

Knudson, C.B and Knudson, W. Hyaluronan binding proteins in development, tissue

homeostasis and disease,

FASEB. J.7:1233-1241, 1993.

Knudson,W., Biswas,C. and Toole, B. P. Interactions between human tumour cells

and fibroblasts stimulate hyaluronate synthesis.

Proc. Natl Acad. Sci. USA, 81:6767–6771, 1984.

Page 17: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

149

Knudson, W., Biswas, C, Li, X, Q., Nemec, R, E and Toole, B.P. The role and

regulation of Tumor-associated hyaluronan.

Ciba Found. Symp. 143: 150-159, 1989.

Knudson, W, Tumor-associated hyaluronan. Providing an extracellular matrix that

facilitates invasion

Am J Pathol.148:1721-1726, 1996.

Kojima, J., Nakamura, N., Kanatani, M., Omori,K. The glycosaminoglycans in human

hepatic.

Cancer. Cancer Res.35: 542-547, 1975.

Koomen, J.M., Li ,D., Xiao, L.C., Liu ,T.C., Coombes ,K.R., Abbruzzese, J.,

Kobayashi, R.Direct tandem mass spectrometry reveals limitations in protein profiling

experiments for plasma biomarker discovery.

J. Proteome Res. 4:972-981, 2005.

Koretz, K., Moller, P., Lehnert, T., Hinz, U., Otto, H.F and Herfarth, C. Effect of

CD44v6 on survival in colorectal carcinoma.

Lancet. 345: 327-328, 1995.

Koyama,H., Hibi,T., Isogai, Z., et al. Hyperproduction of hyaluronan in neu-induced

mammary tumor accelerates angiogenesis through stromal cell recruitment: possible

involvement of versican/PG-M.

Am J Pathol. 170:1086–1099,2007

Laemmli,U.K. Cleavage of structural proteins during the assembly of the head of

bacteriophage T4.

Nature. 227: 680-685, 1970.

Lai,P.H., Chang ,Y., Chen,S.C, Wang, C.C., Liang ,H.C., Chang ,W.C., Sung ,H.W.

Acellular biological tissues containing inherent glycosaminoglycans for loading basic

fibroblast growth factor promote angiogenesis and tissue regeneration. Tissue Eng.

12:2499–2508,2006.

Lambeck, A .J. A., Crijns, A. P.G., Leffers ,N,.Wim,Sluiter,.Klaske, A,. ten

Hoor,Mike Braid.,Ate, G.J van der, Zee., T Daemen, Hans W. Nijman, and W.Martin

Kast. Serum Cytokine Profiling as a Diagnostic and Prognostic Tool in Ovarian

Cancer: A Potential Role for Interleukin 7.

Clinical cancer Res. 13: 2385-2391,2007.

Laurent,U.B.G., Laurent, T.C. On the origin of hyaluronate in blood.

Biochem Int ,2: 195–9, 1981.

Page 18: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

150

Laurent, E.A., Loof L, Nyberg, A., Schroder T. Increased serum levels of hyaluronate

in liver disease.

Hepatology. 5:638-642, 1985.

Laurent, A., Laurent, U.B.G., Lilja, K. & Laurent, C.T. Concentrations of sodium

hyaluronate in serum.

Scand. J. Clin. Lab. Invest. 45: 497.1985.

Laurent, E.A., Hallgren R. Circulating hyaluronate in rheumatoid arthritis:

Relationship to inflammatory activity and the effect of corticosteroid therapy.

Ann Rheum .44:83-88, 1985.

Laurent, T. C., and Fraser, J. R. E. The properties and turnover of hyaluronan. In

Functions of Proteoglycans,

Ciba Foundation Symp.124: 9-29,England, 1986.

Laurent, T.C., Dahl, I.M.S., Dahl, L,B et al. The catabolic fate of hyaluronic acid.

Connect Tissue.

Res. 15:33-41, 1986.

Laurent, T.C and Fraser, J.R.E.Catabolism of hyaluronan. In Degradation of

BioactiveSubstances.

Physiology and Pathophysiology.249-265, CRC Press, Boca Raton, Florida, 1991.

Laurent, T.C and Fraser, J.R. Hyaluronan.

FASEB J. 6: 2397–2404,1992.

Lee, T.H., Wisniewski, H-G and Vilcek, J. A novel secretory tumor necrosis factor-

inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins,

closely, related to the adhesion receptor CD44.

J Cell Biol. 116: 545-557, 1992.

Lesley, J., Hascall, V.C., Tammi, M., and Hyman, R.Hyaluronan binding by cell

surface CD44.

J. Biol. Chem. 275: 26967–26975, 2000.

Leu, A. J., Berk, D. A., Lymboussaki, A., Alitalo, K. & Jain, R. K. Absence of

functional lymphatics within a murine sarcoma: a molecular and functional

evaluation.

Cancer Res. 60, 4324–4327, 2000.

Lindemann, F., Schlimok, G., Dirschedl,P., et al. Prognostic significance of

micrometastatic tumour cells in bone marrow of colorectal cancer patients.

Lancet. 340: 685-689. 1992.

Page 19: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

151

Liotta, L.A., Saidel, M.G., Kleinerman, J. The significance of hematogenous tumor-

cell clumps in the metastatic process.

Cancer Res. 36: 889-894. 1976.

Liotta, L.A., Petricoin ,E.F. Clinical proteomics: written in blood.

Nature.425:905,2003.

Liotta, L.A., Petricoin ,E.F. Serum peptidome for cancer detection:spinning biologic

trash into diagnostic gold

J. Clin. Invest. 116:26–30, 2006.

Lipponen ,P., Aaltomaa, S., Tammi ,R., Tammi ,M., Ågren ,U and Kosma,V.M.High

stromal hyaluronan level is associated with poor differentiation and metastasis in

prostate cancer.

Eur J Cancer. 37:849-856, 2001.

Liu,P.F., Wu,M.C., Cheng,H., Qian,G.X., Fu ,J.L. Clinical significance of expression

of metastasisa2associated splice variants of CD44 mRNA in early primary liver

cancer.

China Natl J New Gastroenterol. 2: 112-114, 1996.

Liu, N., Lapcevich, R.K., Underhill, C.B., Han, Z., Gao, F., Swartz, G., Plum, S.M.,

Zhang, L., and Gree, S.J. Metastatin: a hyaluronan-binding complex from cartilage

that inhibits tumor growth.

Cancer Res. 61, 1022–1028,2001.

Lokeshwar, V.B., Obek, C., Soloway, M.S and Block, N.L. Tumor-associated

hyaluronicacid: a new sensitive and specific urine marker for bladder cancer.

Cancer Res. 57: 773-779, 1997.

Lokeshwar,V.B., Soloway,M.S and Block, N.L. Secretion of bladder tumor-derived

hyaluronidase activity by invasive bladder tumor cells.

Cancer. Res. 131: 21-27,1998.

Lokeshwar, V.B, Obec, C., Phom, H.T., Wei, D., Young, M.J., Duncan R.C.,

Soloway, M.S and Block, N.L. Urinary hyaluronic acid and hyaluronidase: markers

for bladder cancer detection and evaluation of grade.

J. Urol.163, 348-356, 2000.

Lokeshwar,V.B.,Schroeder,G.L.,Selzer,M.G.,Hautmann,S.H.,Posey,J.T.,Duncan,R.C.,

Watson, R., Rose, L., Markowitz,S and Soloway,M.S. Bladder tumour markers for

monitoring recurrence and screening comparison of hyaluronic acidhyaluronidase and

BTA-Stat tests.

Cancer, 95, 61–72, 2002.

Page 20: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

152

Lou, X., Xiao, T.,Zhao, K., Wang., Zheng, H., Lin, D.; Lu, Y., Gao, Y., Cheng, S.,

Liu, S., Xu, N. Cathepsin D is secreted from M-BE cells: its potential role as a

biomarker of lung cancer

J. Proteome Res, 6 (3): 1083– 1092, 2007.

Lowenthal,M. S.,Mehta, A.I., Frogale, K., Russell, W., Bandle, Robyn,P,. Araujo,

BrianL.Hood., Timothy, D. Veenstra.,Thomas P. Conrads., Paul Goldsmith., David

Fishman,4 Emanuel F. Petricoin III,and Lance A. Liotta .Analysis of albumin

associated peptides and proteins from ovarian cancer patients.

Clinical Chemistry.51 :10, 1933-1945,2005.

Lucas, M.G., Green, A.M and Telen, M.J. Characterization of serum In (Lu)-related

antigen: identification of a serum protein related to erythrocyte p80.

Blood .73: 596–600, 1989.

Ludwig, J.A., Weinstein,J.N. Biomarkers in cancer staging, prognosis and treatment

selection.

Nature Reviews Cancer.5 (11):845–856, 2005.

Margolis, R.K., Crockett, C.P., Kiang, W.L and Margolis, R.U.

Biochem. Biophys Acta. 451: 465-469, 1976.

Matsumura,K.,Kawanishi,I.,Fujii,S. et al. Altered expression of E-cadherin in gastric

cancer tissues and carcinomatous fluid.

Br.J.Cancer.66:1122-1130,1992.

Mayer, B., Jauch ,K.W., Gunthert ,U., Figdor, C.G, Schildberg, F.W., Funke ,I and

Johnson,J.P. De-novo expression of CD44 and survival in gastric cancer.

Lancet.342:1019-1022, 1993.

Mayer,S., zur, H.A., Watermann, D.O., Stamm ,S., Jäger ,M., Gitsch, G., Stickeler, E.

Increased soluble CD44 concentrations are associated with larger tumor size and

lymph node metastasis in breast cancer patients.

J Cancer Res Clin Oncol. Nov;134(11):1229-1235. Epub Apr 26, 2008.

McBride, W.H and Bard, J.B. Hyaluronidase-sensitive halos around adherent cells.

Their role in blocking lymphocyte-mediated cytolysis.

J. Exp. Med. 149, 507–515, 1979.

McClay, DR., and Ettensohn, C.A. Cell adhesion in morphogenesis.

Annu. Rev Cell Biol, 3, 319-345. 1987.

Page 21: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

153

McCourt, P.A.G., Ek, B., Forsberg, N and Gustafson, S. Intercellular adhesion molecule-I is

a cell surface receptor for hyaluronan.

J Biol Chem. 269, 30081-30084, 1994.

Mehta, P., Ploutz-Snyder., Robert, Nandi., Jyotirmoy, Rawlins., Sekou,R., Sanderson,

Schuyler, O., Levine, Robert,A. Diagnostic Accuracy of Serum Hyaluronic Acid,

FIBRO Spect II, and YKL-40 for Discriminating Fibrosis Stages in Chronic Hepatitis C

Am J Gastroentology. 103:928-936, 2008.

Meyer, K and palmer J.W. The polysaccharide of the viterous humor.

J Bio Chem.107: 629-634, 1934.

Miyake,K., Underhill, C.B., Lesley, J and Kincade,P.W .Hyaluronate can function as

a cell adhesion molecule and CD44 participates in hyaluronate recognition.

J Exp Med .172: 69-75, 1990.

Mohapathra, S., Yang, X., Wright, J.A., Turley, E.A and Greenberg, A.H. Soluble hyaluronan

receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclinBl expression.

J Exp Med. 183:1663-1668, 1996.

Mulder,J.W.R., Kruyt, P.M., Sewnath, M., Oosting, J., Seldenrijk ,C.A., Weidema,

W.F.,Offerhaus, G.J.A and Pals, S.T. Colorectal cancer prognosis and expression of

exon-v6-containing CD44 proteins.

Lancet. 344: 1470-1472, 1994.

Muller, A., Homey, B., Soto, H., Ge, N., Catron, D and Buchanan, M.E. Involvement

of chemokine receptors in breast cancer metastasis.

Nature. 410:50-56, 2001.

Nikitenko, L.L. Vascular endothelium in cancer.

Cell Tissue Res. 335: 223-240, 2009.

Noble, P.W., McKee, C.M., Cowman, M and Shin, H.S. Hyaluronan fragments

activate an NF-kappa B/I-kappa B alpha auto-regulatory loop in murine macrophages.

J. Exp. Med.183: 2373–2378, 1996.

Noble,P.W. Hyaluronan and its catabolic products in tissue injury and repair.

Matrix Biol.; 21:25–29, 2002.

Omenn,G.S.,States,D.J.,Adamski,M.,Blackwell,T.W.,Menon,R.,Hermjako,b.H.,Apwe

iler,R., Haab,B.B., Simpson ,R.J., Eddes ,J.S, et al.. Overview of the HUPO Plasma

Proteome Project: results from the pilot phase with 35 collaborating laboratories and

multipleanalytical groups, generating a core dataset of 3020 proteins and a publicly-

available database.

Page 22: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

154

Proteomics. 5:3226-3245, 2005.

Paiva,P.,Van, Damme M.P., Tellbach, M., Jones, R.L., Jobling ,T., Salamonsen, L.A.

Expression patterns of hyaluronan, hyaluronan synthases and hyaluronidases indicate

a role for hyaluronan in the progression of endometrial cancer.

Gynecol Oncol.98:193–202. 2005.

Pantel, K., Cote, R.J., Fodstad,O. Detection and clinical importance of

micrometastatic disease. JNatl CancerInst.91:1113-1124, 1999.

Peter, Carmeliet & Rakesh ,K. Jain, review article Angiogenesis in cancer and other

diseases.

Nature .407:249-257 doi:10.1038/35025220,2000.

Peterson, R.M., Yu, Q., Stamenkovic, I., and Toole, B.P. Perturbation of hyaluronan

interactions by soluble CD44 inhibits growth of murine mammary carcinoma cells in

ascites.

Am. J. Pathol., 156, 2159–2167, 2000.

Pia, N., Pia, H., Timo, S., Jani, L., Ritva, H., Ulf-Hakan, S., Taina, P and Tuula, S.

Endostatin inhibits human tongue carcinoma cell invasion and intravasation and

blocks the activation of MMP-2, MMP-9, MMP-13.

J. Biol. Chem. 278: 22404 –22411, 2003

Pirinen,R.T.,Tammi,R.H.,Tammi,M.I.,Paakko,P.K.,Parkkinen,J.J.,Agren,U.M.Expres

sion of hyaluronan in normal and dysplastic bronchial epithelium and in squamous-

cell carcinoma of the lung.

Int J Cancer (Ped Oncol). 79:251-255, 1998.

Pirinen,R.T., Hirvikoski, P., Johansson, R.T., Hollmen ,S., Kosma ,V.M. Reduced

expression of alpha-catenin, beta-catenin, and gamma-catenin is associated with high

cell proliferative activity and poor differentiation in non-small cell lung cancer.

J Clin Pathol. 54:391-395, 2001.

Ponder, B .Cancer Gene losses in human tumours.

Nature, 335:400-402,1988.

Ponta, H., Sherman, L. and Herrlich, P. CD44: from adhesion molecules to signaling

regulators. Nature Rev.

Mol. Cell Biol. 4:33–45, 2003.

Posey, J.T., Soloway, M.S and Ekici ,S. Evaluation of the prognostic potential of

hyaluronic acid and hyaluronidase (HYAL1) for prostate cancer.

Cancer Res. 63: 2638-2644, 2003.

Page 23: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

155

Qinghua Shi and Randall W. King,Chromosome nondisjunction yields tetraploid

rather than aneuploid cells in human cell lines.

Nature.doi: Editor's Summary Cancer and cell division 10.1038/03958 ,2005.

Ramanujan, S., Koenig, G. C., Padera, T. P., Stoll, B. R. & Jain, R. K. Local

imbalance of proangiogenicand antiangiogenic factors: a potential mechanism of focal

necrosis and dormancy in tumours.

CancerRes. 60:1442–1448 ,2000.

Reed, S.I. The role of p34 kinases in the Gl to S-phase transition.

Annu. Rev. Cell Biol. 8: 529-561, 1992.

Rhodes, J. M. Usefulness of novel tumour markers

Annals of Oncology. 10 suppl 4: S 118-S12117,1999.

Ripellino, J.A., Margolis, R.U and Margolis, R.K. Immunoelectron microscopic

localization of hyaluronic acid-binding region and link protein epitopes in brain.

J. Cell Biol. 108:1899-1907, 1989.

Richter, R., Schulz-Knappe,P., Schrader,M., Ständker,L., Jürgens, M., Tammen, H.,

Forssmann ,W.G.Composition of the peptide fraction in human blood plasma:

database of circulating human peptides.

J. Chromatogr. B Biomed. Sci. Appl. 726:25-35, 1999.

Ristamaki, R., Joelsuu, H., Salm, M. et al. Serum CD44 in malignant lymphoma: an

association with treatment response.

Blood.84:238-243,1994.

Ripellino J.A., Margolis, R.U and Margolis, R.K. Immunoelectron microscopic

localization of hyaluronic acid-binding region and link protein epitopes in brain.

J Cell Biol. 108:1899-1907, 1989.

Roboz, J., Greaves, J., Silides ,D., Chahinian, A.P., Holland, J.F. Hyaluronic acid

content of effusions as a diagnostic aid for malignant mesothelioma.

Cancer Res. 45: 1850-1854, 1985.

Rooney,P., Kumar, S., Ponting ,J., Wang, M. The role of hyaluronan in tumour

neovascularization.

Int J Cancer.60:632–636, 1995.

Ropponen, K., Tammi, M., Parkkinen, J., Eskelinen, M., Tammi, R, Lipponen P,

Agren U, Alhava, E., Kosma, V.M. Tumor cell associated hyaluronan as an

unfavorable prognostic factor in colorectal cancer.

Cancer Res. 58:342-347, 1998.

Page 24: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

156

Rowley,J.D. The critical role of chromosome translocations inhuman leukemias.

Annu Rev Genet.32:495-519, 1998.

Ruoslahti, E., Yamaguchi,Y and La ,Jolla. Proteoglycans as modulators of growth

factor activities.

Cancer Research Foundation. 64: 867-869, 1991

Sahab, Z.J., Iczkowski, K.A., Sang, Q.X. Anion exchange fractionation of serum

proteins versus albumin elimination.

Anal Biochem. 368(1):24-32. Epub 2007

Sandra, Z.,Ljiljana ,P,R.,Danilo,V Dušan,V .Human cartilage glycoprotein 39—

biomarker of joint damage in knee osteoarthritis

International Orthopaedics (SICOT). 33:1165–1170, 2009.

Schaider,H., Rech-Weichselbraun,I., Richtig,E., Seidl,H., Soyer,H.P., Smolle,J and

Kerl,H. Circulating adhesion molecules as prognostic factors for cutaneous melanoma

J. Am. Acad. Dermatol.36: 209 - 213, 1997.

Schmits, R., Filmus, J., Gerwin, N., Senaldi, G., Kiefer, F., Kundig, T., Wakeham, A.,

Shahinian, A., Catzavelos, C, Rak, J., Furlonger, C, Zakarian, A., Simard, J.J.L., Ohashi,

P.S., Piage, C.J., Gutierrez-Ramos, J.C and Mak, T.W. CD44 regulates hematopoietic

progenitor distribution, granuloma formation, and tumorigenicity.

Blood. 90:2217-2233, 1997.

Seth, R., Raymond, F.D and Makgoba, M.W. Circulating ICAM-1 isoforms:

diagnostic prospects for inflammatory and immune disorders .

Lancet.338:83-84,1991.

Sherman, L., Sleeman, J., Herrlich, P., Ponta, H., Hyaluronate receptors: Key players in

growth, differentiation, migration and tumor progression.

Curr Opin Cell Biol. 6: 726-733, 1994.

Sidransky D. Emerging molecular markers of cancer.

Nature Rev Cancer.2 (3):210–219, 2002.

Sjobring, U. Isolation and molecular characterization of a novel albumin-binding

protein from group G streptococci.

Infect Immun. 60(9): 3601–3608,1992.

Slevin, M., Kumar, S and Gaffney, J. Angiogenic oligosaccharides of hyaluronan

induce multiple signaling pathways affecting vascular endothelial cell mitogenic and

wound healing responses.

J. Biol. Chem. 277: 41046–41059, 2002.

Page 25: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

157

Slevin, M., West, D., Kumar ,P., Rooney, P., Kumar ,S. Hyaluronan, angiogenesis

and malignant disease.

Int J Cancer.109:793–794,2004.

Spicer, A.P., and McDonald, J.A.. Eukaryotic hyaluronan synthases. Glycoforum:

science of hyaluronan today.

http://www.glycoforum.gr.jp/science/hyaluronan/HA07/HA07E.html,1998.

Sreeramaneni,R., Chaudhry,A., McMahon,M., Sherr,C.J., Inoue. K. Ras-Raf-Arf

signaling critically depends on the Dmp1 transcription factor.

Mol Cell Biol. 25: 220-232, 2005

Stamenkovic, I., Aruffo, A. Hyaluronic acid receptors.

Methods Enzymol. 245:195-216, 1994.

Steinberg ,W. The clinical utility of the CA 19-9 tumour-associated antigen.

Am J Gastroenterol.85:350–355, 1990.

Stern,R. Hyaluronan catabolism: a new metabolic pathway.

Eur J Cell Biol.83:317–325. 2004.

Stauder, R., Eisterer, W., Thaler, J and Gunthert, U. CD44 variant isoforms in non-

Hodgkin's lymphoma: A new independent prognostic factor.

Blood .85:2885-2899, 1995.

Sunil, B. K., Hitesh, N. A., Rajeev ,K. B.,Anil ,Thomas, Shib, D. Band M. Karuna

Kumar.Identification of a Novel Hyaluronic Acid Binding Protein inHuman Breast

Cancer Using a Monoclonal Antibody.

Advances in Biological Research 2 (1-2): 06-12, 2008

Suniti, Misra., B, P. Toole., and Shibnath, Ghatak. Hyaluronan Constitutively

Regulates Activation of Multiple Receptor Tyrosine Kinases in Epithelial and

Carcinoma Cells

J. Biol. Chem. 281:34936-34941, 2006.

Sy, M.S., Guom, Y.J and Stamenkovic, I. Distinct effects of two CD44 isoforms on

tumor growth in vivo.

J Exp Med. 174: 859-866, 1991.

Sy, M.S., Guo, Y.J., and Stamenkovic, I. Inhibition of tumor growth in vivo with a

soluble CD44-immunoglobulin fusion protein.

J. Exp. Med. 176: 623–662, 1992.

Page 26: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

158

Takahashi, K., Stamenkovic, I., Cutler, M., Saya, H and Tanabe, K.K. CD44

hyaluronate binding influences growth kinetics and tumorigenicity of human colon

carcinoma.

Oncogene. 11: 2223-2232, 1995.

Tammi, M,I., Syrjanen, K.J., Saarikoski ,S.V., Kosma ,V.M. High levels of stromal

hyaluronan predict poor disease outcome in epithelial ovarian cancer.

Cancer Res.60:150–155, 2000.

Tammi, M. I., Day, A. J. and Turley, E. A. Hyaluronan and homeostasis: a balancing

act.

J. Biol. Chem.277: 4581–4584 ,2002.

Tarin,D and Matsumura,Y. Recent advances in the study of tumour invasion and

metastasis.

J.Clin.Pathol.47:385-390,1994.

Tawil,N.J., Gowri,V., Djoneidi, M., Nip, J., Carbonetto ,S and Brodt ,P.

Integrinalpha3beta1 can promote adhesion and spreading of metastatic breast

carcinoma cells on the lymph node stroma.

Int J Cancer.66:703-710, 1996.

Teder, P., William, R. Vandivier, Dianhua Jiang, Jiurong Liang, Lauren Cohn, Ellen

Puré, Peter M. Henson and Paul, W. Noble. Resolution of lung inflammation by

CD44.

Science. 296: 155–158. 2002.

Tchetgen ,M.B., Oesterling ,J.E. The effect of prostatitis, urinary retention,

ejaculation, and ambulation on the serum prostate-specific antigen concentration.

Urol Clin North Am.24:283–291,1997.

Thorne, R. F., Legg, J. W. & Isacke, C. M. The role of the CD44 transmembrane and

cytoplasmic domains in coordinating adhesive and signalling events.

J. Cell Sci. 117:373–380. 2004.

Tirumalai, R.S., Chan ,K.C., DaRue ,A.. Prieto, Haleem, J.. Issaq, Thomas

,P.Conrads., and Timothy .D. Veenstra. Characterization of the low molecular weight

human serum proteome. Mol. Cell. Proteomics. 1:1096-1103,2003.

Toole, B.P., Biswas, C and Gross, J. Hyaluronate and invasiveness of the rabbit V2

carcinoma.

Proc Natl Acad Sci. 76: 6299-6303, 1979.

Page 27: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

159

Tool BP. Glycosaminoglycans in morphogenesis. Cell Biology of Extracellular

Matrix. In:

Hay ED, ed. New York: Plenum Press. 259-294,1981.

Toole B.P. Developmental role of hyaluronate.

Connect Tissue. Res.10:93-100, 1982.

Toole, B.P. Hyaluronan and its binding proteins, the hyaladherins.

Curr. Opin. Cell Biol. 2: 839–844. 1990.

Toole,B.P. Proteoglycans and hyaluronan in morphogenesis and differentiation.

Cell Biology of Extracellular Matrix

(Hay, E. D., ed). 305-339, 1991.

Toole, B.P. Hyaluronan, In proteoglycan: Structure, Biology and Molicular

Interactions.

Iozzo, R., ed. marcel Dekker.72: 61-92, 2000.

Toole, B. P. Hyaluronan in morphogenesis.

Semin. Cell. Dev.Biol.12: 79–87, 2001.

Toole, B. P., Wight, T. N and Tammi, M. Hyaluronan–cell interactions in cancer and

vascular disease.

J. Biol. Chem. 277:4593–4596, 2002.

Toole, B.P. Hyaluronan: from extracellular glue to pericellular cue.

Nature reviews cancer. 4:528-539, 2004.

Turley, E, A., Torrance, J. Localization of hyaluronate and hyaluronate-binding

protein on

motile and non-motile fibroblasts.

Exp Cell Res. 161: 17-28 ,1985.

Turley, E.A. Hyaluronan and cell locomotion.

Cancer Metastasis. Rev. 11: 21-30, 1992.

Turley, E. A., Noble, P.W and Bourguignon, L.Y. Signaling properties of hyaluronan

receptors.

J. Biol. Chem. 277:4589–4592, 2002.

Tuxen ,M.K., Soletormos,G., Dombernowsky,P. Tumour markers in the management

of patients with ovarian cancer.

Cancer Treat Rev.21:215–245,1995

Page 28: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

160

Uhl-Steidl ,M., Muller-Holzner, E., Zeimet, A.G., Adolf ,G.R., Daxenbichler ,G.,

Marth, C and Dapunt. Prognostic value of CD44 splice variant expression in ovarian

cancer.

Oncology. 52: 400-406, 1995.

Underhill, C.B., Chi-Rosso, G., and Toole, B.P. Effects of detergent solubilization on

the hyaluronate-binding protein from membranes of simian virus 40-transformed 3T3

cells.

J. Biol. Chem., 258, 8086–8091,1983.

Underhill, C. CD44, The hyaluronan receptor.

J.Cell Sci. 103: 293-298, 1992.

Velikova, G., Banks, R,E., Gearing, A., Hemingway,I., Forbes,M,A., Preston,S.R., et

al. Serum concentrations of soluble adhesion molecules in patients with colorectal

cancer.

Br J Cancer:77:1857–1863, 1998.

Vogt PK., Gymnopoulos M and Hart JR. PI 3-kinase and cancer: changing accents.

Curr Opin Genet Dev. 19: 12-17, 2009.

Voit, C., Kro, M., Rademaker,J, et al. Molecular staging in stage II and III melanoma

patients and its effect on long-term survival.

JClin Oncol.23:1218-1227, 2005.

Volmer, M. W., Stuhler, K., Zapatka, M., Schoneck, A., Klein-Scory,S., Schmiegel,

W., Meyer, H. E., Schwarte-Waldhoff, I. Differential proteome analysis of

conditioned media to detect Smad4 regulated secreted biomarkers in colon cancer.

Proteomics.5 (10):2587–2601, 2005.

Wang, C., Thor, A. D., Moore, D. H., II, Zhao, Y., Kerschmann, R., Stern, R.,

Watson, P. H and Turley, E. A. The overexpression of RHAMM, a hyaluronan-

binding protein that regulates ras signaling, correlates with overexpression of

mitogen-activated protein kinase and is a significant parameter in breast cancer

progression.

Clin. Cancer Res. 4:567-576, 1998.

Watts, N.B. Clinical utility of biochemical markers of bone remodeling.

Clin. Chem. 45:1359-1368, 1999.

Weg-Remers, S., Hildebrandt, U., Feifel, G., Moser, C., Zeitz ,M and Stallmach, A.

Soluble CD44 and Cd44v6 serum levels in patients with colorectal cancer are

independent of tumour stage and tissue expression of CD44v6.

Am JGastroenterol .93: 790–794, 1998.

Page 29: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

161

Weigel, P.H., Hascall, V.C., and Tammi, M. Hyaluronan synthases.

J. Biol. Chem.272:13997–14000, 1997.

Weinberg, R. A. How cancer arises.

Sci. Am. 275, 62–70, 1996.

Weng, L. P., Wu, C. C., Hsu, B. L., Chi, L. M.,Liang, Y., Tseng,C. P., Hsieh, L. L.,

Yu, J. S. Secretome-Based Identification of Mac-2 Binding Protein as a Potential Oral

Cancer Marker Involved in Cell Growth and Motility.

J. Proteome Res, 7, 3765–3775, 2008.

West, D.C., Hampson, I. N., Arnold, F and Kumar, S. Angiogenesis Induced by

DegradationProducts of Hyaluronic Acid.Science.

New Series.228: 1324-1326, 1985.

West,D.C, Kumar ,S. Endothelial cell proliferation and diabetic retinopathy.

Lancet. 1:715–716, 1988.

West ,D.C., Kumar S. The effect of hyaluronate and its oligosaccharides on

endothelial cell proliferation and monolayer integrity.

Exp Cell Res.183:179–196,1989.

Whibley,C., Pharoah,P.D., Hollstein, M. p53 polymorphisms: cancer implications.

Nat Rev Cancer. 9; 95-107, 2009.

Wight, T.N and Merrilees., M.J. Proteoglycans in atherosclerosis and restenosis. key

roles for versican.

Circ.Res. 94: 1158–1167, 2004.

Wollenberg,B., Jan,N.V., Sutier,W., Hofmann, K., Schmitt,U.M., Stieber, P. Serum

levels of intercellular adhesion molecule-1 in squamous cell carcinoma of the head

and neck.

Tumor Biol.18:88–94, 1996.

Xing,R.dong., Chang,Shi-min., LI ,Jian-hua., LI ,Hua., Han, Zheng-xue. Serum

hyaluronan levels in oral cancer patients.

Chinese Medical Journal , Vol. 121 No. 4:327-330,, 2008.

Xue, H., Lu, B., Lai, M. The cancer secretome: a reservoir of biomarkers.

J. Transl. Med, 6, 52, 2008.

Page 30: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

162

Yang, B., Yang, B.L., Savani, R.C and Turley, E.A., Identification of a common

hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link

protein.

EMBO J. 13: 286-296, 1994.

Yang ,X., Wright,J. A. , Turley,E. A. , and Greenberg,A. H. Soluble hyaluronan

receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1

expression.

JEM vol. 183no. 41663-41668, 1996.

Yoneda, M. key molecules to an understanding of intracellular hyaluronan function.

Connective Tissue.33: 227-233, 2001.

Yu, Q., Toole, B.P., and Stamenkovic, I. Induction of apoptosis of metastatic

mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function.

J. Exp. Med. 186:1985–1996, 1997.

Yu, Q. and Stamenkovic, I. Localization of matrix metalloproteinase 9 to the cell

surface provides a mechanism for CD44-mediated tumor invasion.

Genes Dev. 13:35–48, 1999.

Zahalka, M.A., Okon, E., Gosslar, U., Holzmann, B., and Naor, D. Lymph node (but

not spleen) invasion by murine lymphoma is both CD44- and hyaluronate-dependent.

J. Immunol. 154:5345–5355, 1995.

Zalewski, B., Famulski ,W., Sulkowska,M., Sobaniec-Lotowska,M., Piotrowski,Z.,

Kisielewski,W.,Sulkowski,S.CD44 expression in colorectal cancer. An

immunohistochemical study including correlation with cathepsin D immune reactivity

and some tumour clinicopathological features.

Folia Histochem Cytobiol; 39:152-153, 2001.

Zalewski, B. Levels of v5 and v6 CD44 splice variants in serum of patients with

colorectal cancer are not correlated with pT stage, histopathological grade of

malignancy and clinical features

World J Gastroenterol.10(4):583-585, 2004.

Zeimet, A,G., Widschwendter ,M., Uhl-Steidl ,M., Muller-Holzner, E.,

Daxenbichler,G., Marth, C and Dapunt ,O. High serum levels of soluble CD44 variant

isoform v5 are associated with favourable clinical outcome in ovarian cancer

Br. J. Cancer. 76:1646 - 1651, 1997.

Zeng, C., Toole, B.P., Kinney, S.D., Kuo, J.W., and Stamenkovic, I. Inhibition of

tumor growth in vivo by hyaluronan oligomers.

Int. J. Cancer.77: 396–401, 1998.

Page 31: Ahrens, T., Sleeman, J.P., Schempp, C.M., Howells, N., Hofmann, …shodhganga.inflibnet.ac.in/bitstream/10603/10798/15/15... · 2015-12-04 · Deb, T.B and Datta, K. Molecular cloning

163

Zermati Y., Mouhamad S, Stergiou L, Besse B, Galluzzi L, Boehrer S, Pauleau AL,

Rosselli F, D'Amelio M, Amendola R, Castedo M, Hengartner M, Soria JC, Cecconi

F, Kroemer G. Nonapoptotic role for Apaf-1 in the DNA damage checkpoint.

Mol Cell. 28: 624-637, 2007.

Zhang, H., Kelly, G., Zerillo, C., Jaworski, D.M., Hockfield, S. Expression of a

cleaved brain-specific extracellular matrix protein mediates glioma cell invasion in

vivo.

J Neuro Sci .18:2370-2376,1998.

Zhang, J.C., Wang,Z.R., Cheng,Y.J., Yang,D.Z., Shi,J.S., Liang ,A.L., Liu,N.N.,

Wang,X.M. Expression of proliferating cell nuclear antigenand CD44 variant exon 6

in primary tumours and corresponding lymph node metastases of colorectal carcinoma

with Dukes’ stageC or D.

World J Gastroenterol. 9: 1482-1486, 2003.

Zhang, L., Underhill ,C.B., Chen, L. Hyaluronan on the surface of tumor cells is

correlated with metastatic behavior.

Cancer Res. 55: 428-433, 1995.

Zhang,Y.L., Pang,L.Q., Wu,Y., Wang,X.Y., Wang,C.Q., Fan,Y. Significance of Bcl-

xL in human colon carcinoma.

World J Gastroenterol.14: 3069-3073, 2008.

Zhu, L., Hope, T.J., Hall, J., Davies, A., Stern, M., Muller-Eberhard, U., Stern, R and

Parslow, T.G. Molecular cloning of a mammalian hyaluronidase reveals identity with

hemopexin, a serum heme-binding protein.

J Biol Chem. 269: 32092-32097, 1994.

Ziegler,J.L and Buonaguro,F.M. Infectious agents and human malignancies.

Front Biosci. 14: 3455-3464, 2009.

Zink, D., Sadoni,N., Stelzer,E. Visualizing chromatin and chromosomes in living

cells.

Methods. 29:42-50, 2003.