Agenda I.Overview of U.S. EU Cooperative Efforts (Philip Sayre,
EPA) II.Description of Communities of Research (Sally Tinkle, NNCO)
III.Discussion with COR co-chairs (Kai Savolainen, TTL) A.Exposure
through the Life Cycle, with Material Characterization (Richard
Canady, ILSI Research Foundation and Flemming Cassee, National
Institute for Public Health and the Environment) B.Ecotoxicity
Testing and Predictive Models, with Material Characterization
(Henriette Selck, Roskilde University) C.Predictive Modeling for
Human Health, with Material Characterization (Bengt Fadeel,
Karolinska Institutet and Nathan Baker, PNNL) D. Open Discussion on
Three CORs IV.Future Collaborations A. Two to three Video
Conferences for each COR between late April and October hosted by
NNCO and the EU (Sally Tinkle, NNCO) B. Launch of Additional CORs:
29-31 May, Grenoble, NSC meeting (Kai Savolainen, TTL) C. The 2012
U.S. - EU Workshop: 25-26 October, Helsinki (Kai Savolainen, TTL)
D. Workshop Proceedings and Next Steps: www.us-eu.org (Sally
Tinkle, NNCO)www.us-eu.org Slide 2 Overview of U.S. EU Cooperative
Efforts Philip Sayre, EPA Slide 3 Purpose of U.S. E.U. Partnering
Engage researchers, regulators, and granting entities in an active
discussion on EHS research needs Identify research that would
benefit from joint efforts Establish Communities of Research
(CORs): themes, key contacts, and and other collaborative
mechanisms Existing Research Coordination and Programs in the U.S,
the E.U., and beyond E.U.-- FP7 Seventh Framework Programme -
http://ec.europa.eu/research http://ec.europa.eu/research
Industrial Technologies for research projects in Nanotechnologies,
materials and production technologies (NMP) -
http://ec.europa.eu/research/industrial_technologies NanoSafety
Cluster (NSC): a cooperation platform for EU and National research
projects - www.nanosafetycluster.eu U.S.-- 18 Federal Partners;
research coordination through OSTP: NNIs Nanotechnology
Environmental, Health and Safety Implications Working Group --
http://www.nano.gov/nehihttp://www.nano.gov/nehi 2011 EHS Strategic
Research Plan
http://www.nano.gov/node/681http://www.nano.gov/node/681 Individual
Agency & Department websites Additional International
Organizations (ISO, OECD, others) Slide 4 10-11 March 2011 Workshop
Stakeholder Perspectives: E.U., U.S., International Bodies,
Industry, and NGOs Data Needs for Regulatory Decision-making Human
Health Environment Producing Reliable and Reproducible Data for
Assessment and Management When do unique properties, with risk
assessment implications, arise? How do surface modifications and
chemical transformations affect toxicity? Dose metrics, and how are
dose-response data best extended to OELs / environmental concern
concentrations? How relevant are model nanoparticles to
understanding exposures in the workplace? What are the critical
parameters and data needs for understanding the behavior of
nanoparticles in the environment? What are the critical parameters
and data needs for understanding the behavior of nanoparticles in
consumer and general population exposures? Industrial risk
management considerations for worker protection Collaborative
Mechanisms for Joint Work Slide 5 Areas of Interest, Based on 2011
Workshop Over 200 Attendees, from Numerous Stakeholder Groups,
Identified Similar Needs Selected Workshop Findings Ecological
Effects and Fate Source characterization (inventories, actual
sources, and rates of release) Grouping of nanomaterials into
classes that imply fate and effects outcomes Deeper understandings
of bioavailability, transformation, and receptor susceptibility
Health Effects Reference nanomaterials, including positive and
negative controls Harmonized testing protocols, and consideration
of realistic exposure scenarios Cross-cutting Needs for Health and
Ecological Effects, and Environmental Fate Identification of unique
properties: intrinsic and contextual Sets of nanoparticles with
systematic variations; improved detection techniques Informatics to
gather both positive and negative results for trends discoveries
Surface modification effects on particle interactions with
biological and environmental media Assessing Risks in the Workplace
Exposure assessments limited in terms of types of nanomaterials and
scenarios Model nanoparticles : representative, well characterized,
use in measurement and modeling Slide 6 Description of Communities
of Research Sally Tinkle, NNCO Slide 7 Communities of Research for
Nanotechnology EHS Slide 8 The Model: Communities of Practice
formed by groups of people share a significant interest in a topic
and interact regularly to advance that interest, develop a shared
repertoire of resources: experiences, tools, ways of addressing
recurring problemsin short a shared practice do not necessarily
work together on a daily basis. Slide 9 Communities of Research for
NanoEHS (CORs) groups of people: US-EU scientists share a
significant interest: nanoEHS develop a shared repertoire of
resources: experiences, tools, ways of addressing recurring
questions and challenges regular contact: use wikis, webcasts,
conference calls, annual US-EU meeting. Slide 10 CORs for NanoEHS
Launch today With materials characterization in all three: Exposure
through the Life Cycle Ecotoxicity Testing and Predictive Models
Predictive Modeling for Human Health Launch at Nanosafety Cluster
meeting in Grenoble (June) Databases and ontologies Risk assessment
Risk management and control measures Slide 11 Discussion with COR
co-chairs Moderator: Kai Savolainen, TTL 5 minutes for each
presentation 5 minutes for Q & A after each presentation Slide
12 Agenda for Today, and Next Steps I.Overview of U.S.E.U.
Cooperative Efforts (Phil Sayre) II.Description of Communities of
Research (Sally Tinkle) III.Discussion with COR co-chairs
1.Exposure through the Life Cycle, with Material Characterization:
(Richard Canady/US and Flemming Cassee/EU) 2. Ecotoxicity Testing
and Extrapolation towards QSARs, with Material Characterization:
(Steve Klaine/US and Henriette Selck/EU) 3. Predictive Modeling for
Health, with Material Characterization: (Nathan Baker/US and Bengt
Fadeel/EU) Slide 13 Slide 14 Slide 15 Predictive Modeling for Human
Health, with Material Characterization Bengt Fadeel, Karolinska
Institutet Nathan Baker, Pacific Northwest National Laboratory
Slide 16 Predictive Modeling for Health, with Material
Characterization EU chair: Bengt Fadeel, Karolinska Institutet; US
chair: Nathan Baker, Pacific Northwest National Laboratory Topics
covered: Nanomaterial characterization (synthetic identity)
Nanomaterial ontology and informatics High-throughput screening
(HTS) approaches to nanomaterial testing In silico modeling eg.
QSAR (structure- activity) and PBPK approaches to predict
nanomaterial fate and behavior (biological identity) Molecular
simulation of bio-nano- interactions, and other modeling approaches
Slide 17 Toward toxicity testing of nanomaterials in the 21 st
century: a paradigm for moving forward Lai D. Wiley
Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2012
Jan-Feb;4(1):1-15. Slide 18 www.qnano-ri.eu Slide 19 NanoParticle
Ontology: an example view Thomas DG, Pappu RV, Baker NA.
NanoParticle Ontology for Cancer Nanotechnology Research. J Biomed
Inform [in press] www.nano-ontology.org Slide 20 Damoiseaux et al.
No time to lose--high throughput screening to assess nanomaterial
safety. Nanoscale. 2011;3(4):1345-60No time to lose--high
throughput screening to assess nanomaterial safety. Shaw et al.
Perturbational profiling of nanomaterial biologic activity. Proc.
Natl. Acad. Sci. U.S.A. 2008;105:7387-92.Perturbational profiling
of nanomaterial biologic activity. High content/high-throughput
screening Slide 21 ACS Nano.ACS Nano. 2010 Oct 26;4(10):5703-12.
Quantitative nanostructure-activity relationship modeling. Fourches
DFourches D, Pu D, Tassa C, Weissleder R, Shaw SY, Mumper RJ,
Tropsha A.Pu DTassa CWeissleder RShaw SYMumper RJTropsha A Slide 22
COST workshop on Quantitative Nanostructure-Toxicity Relationships
(QNTR) April 2011 The aim of the workshop was to bring together
leaders in the emerging field of computational nanotoxicology to
form an international Community of Practice for accelerated
development of the science of QNTR Copies of all the presentations
at the workshop can be found at:
www.cost.esf.org/events/qntrwww.cost.esf.org/events/qntr A proposal
for a COST action (network) has been submitted; coordinator: Dr.
Lang Tran, Edinburgh Slide 23 Physiologically-based pharmacokinetic
modeling Riviere JE. Pharmacokinetics of nanomaterials: an overview
of carbon nanotubes, fullerenes and quantum dots. Wiley Interdiscip
Rev Nanomed Nanobiotechnol. 2009 Jan-
Feb;1(1):26-34.Pharmacokinetics of nanomaterials: an overview of
carbon nanotubes, fullerenes and quantum dots. Li M, et al.
Physiologically based pharmacokinetic modeling of nanoparticles.
ACS Nano. 2010 Nov 23;4(11):6303- 17.Physiologically based
pharmacokinetic modeling of nanoparticles. Stages involved in
absorption, distribution, metabolism and elimination (ADME). Slide
24 Kagan et al., Carbon nanotubes degraded by neutrophil
myeloperoxidase induce less pulmonary inflammation. Nat. Nanotech.
2010 May;5(5):354-9.Carbon nanotubes degraded by neutrophil
myeloperoxidase induce less pulmonary inflammation. Shi et al. Cell
entry of one-dimensional nanomaterials occurs by tip recognition
and rotation. Nat Nanotech. 2011 Sep 18;6(11):714-9.Cell entry of
one-dimensional nanomaterials occurs by tip recognition and
rotation. Molecular modeling/simulation Slide 25 Getting it done
together: towards US-EU cooperation on modeling of nanomaterial
behavior in biological systems Slide 26 Open Discussion on Three
CORs (15 minutes) Slide 27 Agenda for Today, and Next Steps IV
Future Collaborations (Sally Tinkle and Kai Savolainen) A. Two to
three Video Conferences for each COR B. Launch of Additional CORs
C. The 2012 U.S. E.U. Workshop D. Workshop Proceedings, and Next
Steps Slide 28 Two to three Video Conferences for each COR between
late April and October hosted by NNCO Sally Tinkle, NNCO Slide 29
Launch of Additional CORs: 29-31 May, Grenoble, NSC meeting Prof.
Kai Savolainen, TTL Slide 30 Next NanoSafety Cluster meeting to be
held in Grenoble, France on Thursday, May 31, 2012 (during SIIN
ERA-Net Meeting, May 29-31) Agenda for the NanoSafety Cluster
Meeting, May 31: 9-12Strategic Research Agenda for NanoSafety
2015-2020: Now 14 thematic WG preparing justification of research
priorities to be chosen, Editorial Group responsible for strategic
perspective In the strategy document strategy issues under vision,
introduction plus justification and elements of the strategy,
cross-cutting issues, recommendations and conclusions on research
priorities, will be dealt with As a part of integration, the 14 WG
create 4 larger overarching themes: 1) material identity; 2)
transformation & exposure; 3) hazard mechanisms; and 4) risk
prediction tools Future Collaborations Slide 31 Agenda for the
NanoSafety Cluster meeting in Grenoble on May 31, 2012 12-13Launch
of 3 Additional CoRs and request expression of interests for their
chairs and members: Database + Ontology Risk Assessment Risk
Management and Control The goal is to lauch the three remaining
CoR's in Grenoble and to have the US colleagues to attend
discussions in Grenoble on-site if possible Slide 32 The 2012 U.S.
EU Workshop: 25-26 October, Helsinki the workshop will follow-up
and further elaborate the discussions that begun at the "U.S.-EU
bridging nanoEHS research - A Joint Workshop" held on 10-11 March
2011 in Washington currently drafting the program with parallel
sessions for CORs; feedback from NNCO and EC on the proposed agenda
(program, for EC Kai Savolainen and Kenneth Dawson) room for 120
persons (including invited speakers and guests) Slide 33 Workshop
Proceedings and Next Steps: www.us-eu.org Sally Tinkle, NNCO
www.us-eu.org Slide 34 A. Two to three Video Conferences for each
COR between late April and October hosted by NNCO and EU 1. Please
e-mail COR co-chairs if interested in one of Existing CORs or use
the sign-up sheets in the back of the room 2. Please e-mail one of
the U.S. or EU Contacts to get on the mailing list or express
interest in a new COR topic: a. NNCO Contact Diana Petreski:
[email protected] b. EU Contact Nicolas Segebarth:
[email protected]@ec.europa.eu B.
Discussion on Additional CORs: 31 May, Grenoble, SIINN-NSC meeting
C. The 2012 U.S. EU Workshop: 25-26 October, Helsinki D. Workshop
Proceedings and Next Steps: www.us-eu.orgwww.us-eu.org Questions
and Answers Future Collaborations
