Agenda:

- Certification Platform: Training - I round

- Beta testers proposals

- Congress presentations

- Paper “check for axes”

XIII PMT meeting – October 24, 2012

Platform: Training Phase

2 Images (Scheltens=0,3)

Feedback

6 Images (Scheltens=0,1,2,3,4,4) Feedback +-

Certification set

10 Images (2 x Scheltens=0,1,2,3,4) Feedback +-

Certification set

Platform: Training round I

https://sodium.crulrg.ulaval.ca/hippocampus/

10 naives created account

9 naives completed training round 1

5 tracers are planned to complete segmentations by early November

3 tracers are “uncertain”

3 tracers are lacking

Platform: Training round I

Platform: Training round I

Platform: User Account

Platform: Administrator Visibility

Platform: Uploads UCF

Platform: Uploads UCF

Platform: MultiTracer Version

Platform: Parameters

Platform: Discrepancies in segmentation

Platform: Discrepancies in segmentation

Platform: Statistics - Users

Platform: Statistics - Segmentations

Platform: Statistics - Segmentations

Platform: Statistics - Segmentations

Platform: Statistics - Segmentations

Platform: Statistics - Segmentations

Platform: Statistics - Segmentations

Platform

Expansion SOPs

Sent to 5 possibly interested companies

Proposal by Adam Schwarts

Bioclinica also interested to fund cooperatively

Will promote to next PPSB meeting (next week)

Discussed with Maria Carrillo, she said that the AA may offer a neutral forum through which this could be funded/contracted.

- CTAD (October, 29-31 2012)Definition of the Harmonized Protocol for Hippocampal Segmentation

- DGPPN Symposium 2012 Berlin (Andreas Fellgiebel, Stefan Teipel)Segmentation of the hippocampus: Towards a joint EADC-ADNI harmonized protocol

- AAN (March 16-23, 2013) EADC-ADNI Benchmark Images of Harmonized Hippocampal Segmentation

- AD/PD (March 6-10, 2013)Definition of Harmonized Protocol for Hippocampal Segmentation

Congress Presentations

Papers describing the project

Survey of protocols (preliminary phase; published, JAD 2011)Operationalization (preliminary phase; I revision, Alzheimer’s & Dementia, MS n. ADJ-D-12-00094)

Axes check short report (Brescia Team, in progress)

Delphi consensus (Brescia Team, in progress)Master tracers’ practice and reliability (Brescia Team, in progr)

Development of certification platform (Duchesne and coll)Validation data (Brescia Team – companion paper 1)Protocol definition (Brescia Team – companion paper 2)Validation vs pathology (TBD)

DO

NE

IN P

RO

GR

ES

S P

LA

NN

ED

VALIDATION VS CURRENT PROTOCOLSASSESSMENT OF SOURCES OF

VARIANCE TRAINING SET DEVELOPMENT

VALIDATION VS PATHOLOGY

GOLD STANDARD

Harmonized ProtocolADNI scans: 2 x 5 Scheltens’s

atrophy score x 2 sides x 2 magnet strengths (1.5-3T)

Total per rater: 40 hippos

Harmonized ProtocolADNI scans: 2 sides x 5 Scheltens’s atrophy scores

x 3 time points (bl-1y-2y) x 3 scanners (+ retracing @ bl)

x 2 magnet strengths (1.5-3T)Total per rater: 240 hippos

Assessment of variance due to rater and center

Local ProtocolADNI scans: 2 x 5 Scheltens’s atrophy scores

x 2 sides x 2 magnet strengths (1.5-3T)

Harmonized ProtocolADNI scans: 2 x 5 Scheltens’s atrophy score x

2 sides x 2 magnet strength (1.5-3T)Total per rater: 40 hippos Harmonized Protocol:

Pathological datasets: Mayo Clinic and NYU

Total: about 40 hippos

TrainingADNI scans: 10 at 1.5T x 2 sides x 7

SUs x 2 tracing roundsTotal per rater: 40 hippos

20 naïve tracers 5 master tracers 1 tracer

REFERENCE PROBABILISTIC MASKS

with 95% C.I.

QUALIFICATION QUALIFICATION

Best 5 naïve tracers

Assessment of variance due to side, trace-retrace, atrophy, time, scanner, rater

TRAINING SET

Assessment of agreement with volume on pathology or ex vivo

MRI and correlation with neuronal density

GANTT

Publication Policy

STEERING COMMITTEE (SC)

This is made of: (i) the Principal Investigator (P.I.; G.B. Frisoni) (ii) the co-Principal Investigator (co-P.I.; C.R. Jack); (iii) the leader of the Statistical Working Group (S. Duchesne).The SC is chaired by the P.I. and deliberates by majority.

STANDARD FORM for submission:

TITLE of PROPOSAL:PI / CENTRE:AIM of the PROJECT:METHODS of the PROJECT:WHAT IS ASKED to the SC of the HARMONIZED HIPPOCAMPAL PROTOCOL WHAT IS OFFERED to the HARMONIZED HIPPOCAMPAL PROTOCOL PROJECT/COMMUNITY:

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