highly efficient oxygenatorSwith integrated caScade arterial filter

AF PLUS

Reduces microembolic activity during CPB

Optimizes priming

High performance gas exchange

Optimizes pressure resistance

BLOOD\BODY FLUID CONTACT LAYER

ALKALINE CHAINS SPREAD ACROSS THE SURFACE YELDING A STABLE COATING THROUGH HYDROPHOBIC INTERACTIONS

LAYER OF HYDRATATION AROUND PC - WITH A COATED SUBSTRATETHE BLOOD THEREFORE “SEES” A LAYER OF WATER

ZWITTERIONIC PC GROUPS EXPRESSED OUTWARDS FROM THE SURFACE

FOREIGN SURFACE

FOREIGN SURFACE

PHOSPHORYLCHOLINE COATING

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THe PaTH Of BiOCOmPaTiBiliTy

Phosphorylcoline or PC is the predominant lipid headgroup found in the outer layer of cell membranes. PC has a natural affinity for water and binds water tightly around itself. as a result, the outer layer of the cell membrane does not promote clots formation (thrombosis).

•lowthrombogenic•lowinflammatory•stable•resistanttobacterialadhesion•resistanttoproteindeposition

arterialbloodoutlet

cardioplegiablood outlet

venous blood inlet

H.E. water in/out

purgingline

80 μm

38 μm

CascadeArterialFilter

af PlUS OXyGeNaTOR mODUle WiTH iNTeGRaTeD CaSCaDe aRTeRial filTeR

•PrimingReduction

•LowContactSurfaceArea

•ClinicalFlexibility

FULL INTEGRATED ARTERIAL FILTER SELF-VENTING TECHNOLOGY

Arterial FIlter Screen

Gas Pressure 0-15 mmHgBlood Pressure 50-300 mmHg

A.L.ONE AF PLUS OPTimiZeD PReSSURe ReSiSTaNCe OXyGeNaTOR mODUle WiTH iNTeGRaTeD CaSCaDe aRTeRial filTeR

TECHNICAL CHARACTERISTICS

Priming volume: 225 mlContact surface area: 1.65 m2

Maxbloodflowrate: 7.0l/minCascadeArterialFilterporesize: 80μm+38μm

innovative Heat exchanger Heat exchanger surface area: 0.08m2

H.E.PerformanceFactor: η=0.64(@4l/min)Coating: PC phosphorylcholine

O2T vs Qb

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SKIPPER SINGLE VENOUS CARDIOTOMY RESERVOIR

Conical dispenser to reduce suckers’

microembolic activity

TECHNICAL CHARACTERISTICS

Maxvolumecapacity4600ml(approx)Maxoperatinglevel4500ml(approx)Min.operatinglevel200ml(approx)VenousFilterPoreSize: 80μmCardiotomyFilterPoreSize: 40μmCardiotomy reservoir ready for vacuum(equipped with over-under safety valve)

Connectors: 6x1/4” 1 x POS lock 1x3/8” 2 x luer lock

1 x POS lock - luer lock

1 x Unfiltered luer lock

•Clinicalflexibility•low contact surface•agile PC Coating•High volume Capacity•low Gme activity•easy-to-use holder

REMOWELL DUAL CHAMBER VENOUS RESERVOIR LIPIDS AND LEUCOCYTES REMOVAL

• Despite improvements in cardiopulmonary bypass (CPB) brain injury remains a significant sequela of cardiac surgery.*•Cardiopulmonary bypass is associated with an inflammatory reaction that involves activation of plasma proteins and cells. •Activationofleukocytes,inparticularneutrophils, directly contributes to issue and organ injury.*

supernatantseparator level

CARDIOTOMYTECHNICAL CHARACTERISTICS

•Capacity(activatedbloodsection): 1800ml(approx)•Twostepslipid-leukocytesdepletion:•Multilayercascadefiltration (for lipids and leukocytes) •Supernatantseparator (lipids only)

Cardiotomy ready for vacuum (equipped with over-under safety valve)

Connectors: 2x1/4” 1x3/8” 2 x luer lock 1 x POS lock - luer lock 1x1/4”CellSaveroutletLine

BLOOD DENSITY SEPARATION TIME [min]

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VENOUS RESERVOIRTECHNICAL CHARACTERISTICS

Capacity (nonactivatedbloodsection): 3200ml(approx)FilterPoreSize: 80μmReady for vacuum (equipped with over-under safety valve)Connectors: 2x1/4” 1x3/8” 2 x luer lock 1xPOSLock-1/4” 1 x luer lock unfiltered 1x1/4”Dedicatedintracavitaryport

Conical dispenser to reduce suckers’ microembolic activity

The diffuse brain damage (DBD) after cardiac operation is reported as a frequency within a range of between 20% and 80%.karl Gunnar Engstrom. The embolic potential of liquid fat in pericaldial suction blood, and its elimination. Perfusion 2003; 18:69-74

Current estimates indicate that > 50% of patients who undergo to CPB have neurological or neuropsychological deficits during the first week after surgery, 10% to 30% have long-term or permanent deficits, and 1% to 5% experience severe disability or die.William R. Brown et al. Longer duration of cardiopulmonary bypass is associated with greater numbers of cerebral microemboli. Stroke2000; 31:707-713

The scavenging of pericardial suction blood is a potential mayor source of lipid emboli during cardiopulmonary by pass. Robert F. Brooker et al. Cardiotomy Suction: a Major Source of Brain Lipid Emboli during Cardiopulmonary bypass. Ann Thorac Surg 1998; 65: 1651-5

Lipid particles in the side range of 10 μm to were characterized in shed mediastinal blood, until 300,000 particles per milliliter of blood were found.Atli Eyjolfsson, Henrik Jonsson et al. Charatcterization of Lipid Particles in Shed Mediastinal Blood. Ann Thorac Surg 2008; 85: 978-81

Embolization of lipids is not a phenomenon restricted to the brain, but affected other organs which kidneys1, spleen1 and lung2.1 Henrik Jonsson et al. Differential Distribution of Lipid Microemboli After Cardiac Surgery. Ann Thorac Surgery 2006; 81: 643-9 2 AJ de Vries et al. The rationale for fat filtration during cardiac surgery. Perfusion 2002; 17: 29-33

Activation of the systemic inflammatory response during CPB has been a mayor problem for clinicians because of the potenzial deleterious effect on organs such as the heart, brain, lung, kidneys. one strategy may be the use of leukocyte-depleting filters. Oliver Warren et al. The effect of various leukocyte fitration strategyes in cardiac surgery. Eur J Cardiothorac Surg 2007; 31: 665-676 Shalini Boodram et al. Use of Leukocyte-depleting Filters During Cardiac Surgery with Cardiopulmonary bypass: A Review. JECT 2008; 40: 27-42

*REMOWELL REFERENCES

a.l.ONe af Plus (1.65 m2)AG5204 (N°3pcs/pack)

SKIPPER AF PlusAG5214 (N°2pcs/pack)

REMOWELL AF Plus AG5230 (N°1pcs/pack)

EU2331 (N°1pcs/pack) Holder for Oxygenators

EU2054/P (N°1pcs/pack) Holder for a.l.ONe gas module

ORDERINg gUIDE

Distribuito daDistributed byDistribuè parVertriebDistribuido por

Prodotto daManufactured byFabriquè parHerstellerFabricado por

Eurosets s.r.l.Strada Statale 12, n°14341036 Medolla (MO) ItalyTel: +39 0535 660311Fax: +39 0535 51248E-mail: info@eurosets.comeurosets.com

Rev. 12 / 2017

© Copyright 2017 by Eurosets S.r.l. - Catalogue, products, pictures may differentiate from the actual product appearance. Specifications are subject to change without prior notice.

SiNGle VeNOUS CaRDiOTOmy ReSeRVOiRRE

SERV

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OXYGENATOR MODULE

DUal CHamBeR VeNOUS ReSeRVOiRliPiDS aND leUCOCyTeS RemOVal

COMBINE