Advanced Micro- and Nanofluidics Revolutionizing the Point

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Advanced Micro- and Nanofluidics Revolutionizing the Point-of-Care Diagnostics Industry

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D i s r u p t i ve m i c ro f l u i d i c t e c h n o l o g i e s e n a b l i n g d e c e nt ra l i zat i o n o f d i a g n o s t i c t e s t s

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1.1 The Strategic Imperative 8™ Factors creating Pressure on Growth in the Microfluidics- and Nanofluidics-based Point of Care Diagnostics Industry

Source: Frost & Sullivan

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1.1 The Strategic Imperative 8™ (Continued)

Customer Value Chain

Compression

Innovative Business

Models

Transformative Mega

Trends

Customer value chain compression as a result of advanced technologies, Internet platforms, and other direct-to-consumer models that enables reduction in friction and the number of steps in customer journeys

A new revenue model that defines how a company creates and capitalizes economic value, typically impacting its value proposition, product offering, operational strategies, and brand positioning

Global forces that define the future world with their far-reaching impact on business, societies, economies, cultures, and personal lives

The internal organizational behaviors that prevent a company from making required changes

Internal Challenges

Geopolitical Chaos Competitive Intensity Disruptive Technologies

Chaos and disorder arising from political discord, natural calamities, pandemics, and social unrest that impact global trade, collaboration, and business security

A new wave of competition from start-ups and digital business models that challenge the standing conventions of the past, compelling established industries to re-think their competitive stance

New, disruptive technologies that are displacing the old, and significantly altering the way consumers, industries, or businesses operate

Collaboration between previously disparate industries to deliver on whitespace cross-industry growth opportunities

Industry Convergence


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1.2 The Impact of the Top Three Strategic Imperatives on the Microfluidics- and Nanofluidics-based Point of Care Diagnostics Industry

DISRUPTIVE TECHNOLOGIES GEOPOLITICAL CHAOS INDUSTRY CONVERGENCE

• New materials and fabrication technologies are already being explored for low cost mass production of devices.

• Point of care (POC) diagnosis can be expected to be more autonomous enabling at-home tests in 3 to 5 years.

• Participants in the microfluidic POC diagnosis industry have made use of the opportunity and adapted their platforms for detection and management of COVID-19. Some platforms developed by diagnostic companies such as LightDeck Diagnostics, when approved for diagnostic use, will ease the entry of the company into the industry.

• The trend of decentralized medical testing of diseases will continue in the years to come.

• POC diagnostic platforms are increasingly being connected to the Internet to enable rapid assessment of health and updated health records.

• Epidermal microfluidic devices enabling real-time monitoring of health can be expected to thrive in the market in the next 5 years.

SI8

The high cost of the current microfluidic cartridge readers and difficulty in fabricating complex microfluidic devices demand adoption of disruptive sensor and fabrication technologies to develop more autonomous and cost-effective devices.

• A huge demand for accurate POC diagnostics and decentralized healthcare was witnessed during COVID-19, for effective management of the disease.

• As laboratories are overloaded with COVID-19 tests, POC tests for other infectious diseases and chronic diseases are required.

• Healthcare is shifting toward a more value-based care and personalized patient care.

• Integrating POC diagnosis devices with information technologies will enable physicians to track their patient’s progress and improve clinical outcome.

Wh

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1.3 About the Growth Pipeline Engine ™

Frost & Sullivan’s Growth Pipeline Engine™ supports clients through all 5 phases of growth from developing, evaluating, and prioritizing opportunities to building and implementing go-to-market strategies and optimizing opportunities. The objective of this study is to be a client’s first step on a growth journey.


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1.4 Growth Opportunities Fuel the Growth Pipeline Engine™

The Growth Pipeline EngineTM The Innovation Generator™

An

alytical P

ersp

ective

s

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2.1 Scope of the Research

This research service (RS) explores the emerging microfluidic and nanofluidic technologies employed for point-of-care diagnosis of health status and diseases. Microfluidic-based point-of-care diagnostic devices can improve accessibility, affordability and accuracy of diagnostic tests, thus enabling rapid clinical decisions and better disease management leading to enhanced clinical outcomes.

Microfluidics which manipulate small volumes of fluid in microchannels enable gentle manipulation of cells and molecules and precise control of experimental conditions. It allows miniaturization of bulk assays in small devices requiring small volumes of samples and reagents and integration of several components for multiplexing analysis and achieving higher throughput.

This RS explores the advantages and challenges of traditional as well as emerging materials and fabrication technologies for the point-of-care applications. Various nanofluidic phenomena being investigated for point-of-care diagnosis is also reported. The report also covers some of the remarkable innovations in different segments of the industry, and also lists OEM manufacturing companies supporting innovations in the field.

The drivers and challenges of the microfluidics and nanofluidics-based point-of-care diagnostics industry are explored in detail. Notable funding and acquisition activities in the last three years are also investigated. The growth opportunities offered by autonomous microfluidic devices, 3D printing, flexible microfluidics and integration with information technologies are discussed. Strategic recommendations to succeed in the space are also put forth.

In addition to the above, this research service also offers insights on the IP landscape and the key patents in the last six years.


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3.1 Microfluidics and Nanofluidics Scale down a Laboratory onto a Chip

Length scale

Nanofluidics

Microneedles

Microanalysis systems

Microfilters or microreactors

Micropumps/valves/flow sensors

“1Microfluidics is the science and technology of systems that process or manipulate small (10-9 to 10-18 litres) amounts of fluids, using

channels with dimensions of tens to hundreds of micrometres”. At least one critical dimension, width, depth or radius, of the

microfluidic device is in the micro scale. The microfluidic channels confine, guide, mix and manipulate fluids within them.

Microfluidics allows precise control of fluids of small volumes involving low energy consumption.

“2Nanofluidics is the study of fluids confined in structures of nanometric dimensions (typically 1−100 nm)”. As molecules become

similar in size to the channels in nanofluidics, the technology deals with a large spectrum of characteristic lengths that induce coupled

phenomena and complex fluid behaviors. Though it has existed for several years, the name ‘nanofluidics’ evolved only recently on

account of recent technological progress in nanoscience and technology.

Applications in Life Sciences

Note: 1G.M. Whitesides., 2006 Nature (442) 368-373. 2Simon Gravelle. Nanofluidics: a pedagogical introduction. 2016. hal-02375018. 3Nam-Trung Nguyen; Steven Wereley; Seyed Ali Mousavi Shaegh, Fundamentals and Applications of Microfluidics, Third Edition , Artech, 2019. Source: Frost & Sullivan

Microfluidics and Nanofluidics-based Point of Care Diagnostics Industry: Length and Volume Scale of Microfluidic and Nanofluidic Devices3

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6.2 Growth Opportunity 1: Self-contained Microfluidic Devices to Enable Expanded Scope of POC Diagnostics

Frost & Sullivan has identified 10 Growth Processes that serve as levers for determining and evaluating new Growth Opportunities.

Growth Processes

Customer and Branding Distribution

Channel Optimization

Geographic Expansion

Competitive Strategy

New Product Development

New Product Launch

Vertical Market Expansion

Strategic Partnering

Mergers & Acquisitions

Technology and IP

Relevant Industries for this Growth Opportunity Applicable Regions

Industrial Automation

Environmental

Oil & Gas

Building Technologies

Consumer Electronics

Consumer Mobility

Commercial Mobility

Chemicals & Materials

Ag., Food & Nutrition

Test & Measurement

Aerospace

Defense

Security

Communications Tech

Information Tech

Pharma & Biotech

Advanced Medtech

Fintech

North America

Latin America

Cent/East Europe

Asia-Pacific

Africa

China

South Asia

Middle East

European Union

UK

Japan

Oceania

2 Years Timeline for Action Base Year 2020 Source: Frost & Sullivan

Disruptive Technologies

R&D Investment

Technology Convergence

R&D Partnerships

R&D Outsourcing


Technology Sourcing

IP Monetization Preview

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6.3 Growth Opportunity 2: 3D Printing to Enable Low-cost Disposable Point of Care Devices


Growth Processes






New Product Launch




Technology and IP



Environmental

Oil & Gas



Consumer Mobility

Commercial Mobility



Test & Measurement

Aerospace

Defense

Security

Communications Tech

Information Tech

Pharma & Biotech

Advanced Medtech

Fintech

North America

Latin America

Cent/East Europe

Asia-Pacific

Africa

China

South Asia

Middle East

European Union

UK

Japan

Oceania



R&D Investment


R&D Partnerships

R&D Outsourcing


Technology Sourcing

IP Monetization 3 Years Timeline for Action Base Year 2020

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6.4 Growth Opportunity 3: Flexible Microfluidics to Enable Real-time Assessment of Health


Growth Processes






New Product Launch




Technology and IP



Environmental

Oil & Gas



Consumer Mobility

Commercial Mobility



Test & Measurement

Aerospace

Defense

Security

Communications Tech

Information Tech

Pharma & Biotech

Advanced Medtech

Fintech

North America

Latin America

Cent/East Europe

Asia-Pacific

Africa

China

South Asia

Middle East

European Union

UK

Japan

Oceania

Source: Frost & Sullivan 3 Years Timeline for Action Base Year 2020


R&D Investment


R&D Partnerships

R&D Outsourcing


Technology Sourcing

IP Monetization Preview

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6.5 Growth Opportunity 4: Integration with Communication Technologies to Enable eHealth Diagnostics


Growth Processes






New Product Launch




Technology and IP



Environmental

Oil & Gas



Consumer Mobility

Commercial Mobility



Test & Measurement

Aerospace

Defense

Security

Communications Tech

Information Tech

Pharma & Biotech

Advanced Medtech

Fintech

North America

Latin America

Cent/East Europe

Asia-Pacific

Africa

China

South Asia

Middle East

European Union

UK

Japan

Oceania



R&D Investment


R&D Partnerships

R&D Outsourcing


Technology Sourcing

IP Monetization

Defense Fintech

2 Years Timeline for Action Base Year 2020 Prev

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Why Frost, Why Now?

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Our Expertise

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• ROI & MARGIN: Implementation Excellence

• TRANSFORMATIONAL GROWTH: Industry Leadership

Client Impact

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Legal Disclaimer

Frost & Sullivan is not responsible for any incorrect information supplied by companies or users. Quantitative market information is based primarily on interviews and therefore is subject to fluctuation. Frost & Sullivan research services are limited publications containing valuable market information provided to a select group of customers. Customers acknowledge, when ordering or downloading, that Frost & Sullivan research services are for internal use and not for general publication or disclosure to third parties. No part of this research service may be given, lent, resold, or disclosed to noncustomers without written permission. Furthermore, no part may be reproduced, stored in a retrieval system, or transmitted in any form or by any means—electronic, mechanical, photocopying, recording, or otherwise—without the permission of the publisher.

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Advanced Micro- and Nanofluidics Revolutionizing the Point